locus-tag	class	description
DGWBC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DGWBC_RS00015	COG0284	orotidine-5'-phosphate decarboxylase activity
DGWBC_RS00030	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DGWBC_RS00035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DGWBC_RS00040	COG1752	Esterase of the alpha-beta hydrolase superfamily
DGWBC_RS00045	COG1959	2 iron, 2 sulfur cluster binding
DGWBC_RS00055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGWBC_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DGWBC_RS00060	COG2813	Specifically methylates the guanine in position
DGWBC_RS00070	COG1104	cysteine desulfurase activity
DGWBC_RS00075	COG0822	iron-sulfur transferase activity
DGWBC_RS00135	COG0288	reversible hydration of carbon dioxide
DGWBC_RS00165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DGWBC_RS00170	COG1917	Cupin 2, conserved barrel domain protein
DGWBC_RS00215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DGWBC_RS00220	COG2003	Belongs to the UPF0758 family
DGWBC_RS00280	COG0720	synthase
DGWBC_RS00285	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS00305	COG0613	PHP domain protein
DGWBC_RS00310	COG1692	metallophosphoesterase
DGWBC_RS00320	COG0784	Response regulator, receiver
DGWBC_RS00330	COG1490	D-aminoacyl-tRNA deacylase activity
DGWBC_RS00340	COG2081	HI0933 family
DGWBC_RS00365	COG0285	dihydrofolate synthase activity
DGWBC_RS00380	COG1704	LemA family
DGWBC_RS00395	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS00425	COG0640	Transcriptional regulator
DGWBC_RS00430	COG0215	cysteine-tRNA ligase activity
DGWBC_RS00435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DGWBC_RS00475	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS00480	COG5002	protein histidine kinase activity
DGWBC_RS00500	COG1803	Methylglyoxal synthase
DGWBC_RS00505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DGWBC_RS00515	COG0581	inorganic phosphate transmembrane transporter activity
DGWBC_RS00520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DGWBC_RS00530	COG0704	Plays a role in the regulation of phosphate uptake
DGWBC_RS00550	COG1793	dna ligase
DGWBC_RS00550	COG3285	dna ligase
DGWBC_RS00585	COG2197	response regulator
DGWBC_RS00610	COG0437	4 iron, 4 sulfur cluster binding
DGWBC_RS00615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DGWBC_RS00620	COG0439	Biotin carboxylase
DGWBC_RS00625	COG5557	Pfam Polysulphide reductase, NrfD
DGWBC_RS00640	COG1704	LemA family
DGWBC_RS00645	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DGWBC_RS00670	COG0012	GTP binding
DGWBC_RS00680	COG0658	competence protein
DGWBC_RS00680	COG2333	competence protein COMEC
DGWBC_RS00695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DGWBC_RS00700	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DGWBC_RS00720	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DGWBC_RS00730	COG3956	TIGRFAM MazG family protein
DGWBC_RS00750	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DGWBC_RS00760	COG0735	belongs to the Fur family
DGWBC_RS00765	COG0477	Major facilitator Superfamily
DGWBC_RS00775	COG0167	dihydroorotate dehydrogenase activity
DGWBC_RS00785	COG1121	(ABC) transporter
DGWBC_RS00790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DGWBC_RS00800	COG0493	'glutamate synthase
DGWBC_RS00800	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DGWBC_RS00805	COG0543	2 iron, 2 sulfur cluster binding
DGWBC_RS00815	COG1104	cysteine desulfurase activity
DGWBC_RS00820	COG1959	2 iron, 2 sulfur cluster binding
DGWBC_RS00825	COG3620	sequence-specific DNA binding
DGWBC_RS00825	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DGWBC_RS00825	COG0617	tRNA 3'-terminal CCA addition
DGWBC_RS00850	COG0484	heat shock protein binding
DGWBC_RS00885	COG0573	inorganic phosphate transmembrane transporter activity
DGWBC_RS00890	COG0573	inorganic phosphate transmembrane transporter activity
DGWBC_RS00895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DGWBC_RS00915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DGWBC_RS00920	COG0124	histidyl-tRNA synthetase
DGWBC_RS00930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DGWBC_RS00935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DGWBC_RS00940	COG0235	Class ii aldolase
DGWBC_RS00945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DGWBC_RS00950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DGWBC_RS00960	COG0464	growth
DGWBC_RS00975	COG0789	Transcriptional regulator
DGWBC_RS00995	COG0569	domain protein
DGWBC_RS01000	COG0569	domain protein
DGWBC_RS01025	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DGWBC_RS01030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DGWBC_RS01035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DGWBC_RS01050	COG1979	alcohol dehydrogenase
DGWBC_RS01060	COG0187	DNA topoisomerase II activity
DGWBC_RS01075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DGWBC_RS01080	COG0668	transmembrane transport
DGWBC_RS01120	COG0306	phosphate transporter
DGWBC_RS01125	COG0194	GDP metabolic process
DGWBC_RS01145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGWBC_RS01145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DGWBC_RS01150	COG0671	phosphoesterase, PA-phosphatase related
DGWBC_RS01155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DGWBC_RS01165	COG1794	racemase activity, acting on amino acids and derivatives
DGWBC_RS01190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DGWBC_RS01200	COG0564	pseudouridine synthase activity
DGWBC_RS01205	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DGWBC_RS01210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DGWBC_RS01220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DGWBC_RS01225	COG1160	GTP binding
DGWBC_RS01230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DGWBC_RS01235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DGWBC_RS01245	COG2226	methyltransferase
DGWBC_RS01250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DGWBC_RS01260	COG2226	methyltransferase
DGWBC_RS01270	COG1610	YqeY-like protein
DGWBC_RS01295	COG2801	Transposase and inactivated derivatives
DGWBC_RS01320	COG2205	protein histidine kinase activity
DGWBC_RS01325	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS01390	COG3422	double-strand break repair
DGWBC_RS01430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DGWBC_RS01440	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DGWBC_RS01455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DGWBC_RS01460	COG1131	(ABC) transporter
DGWBC_RS01495	COG0514	ATP-dependent DNA helicase (RecQ)
DGWBC_RS01500	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DGWBC_RS01505	COG0789	Transcriptional regulator
DGWBC_RS01630	COG0442	prolyl-tRNA aminoacylation
DGWBC_RS01650	COG0750	zinc metalloprotease
DGWBC_RS01655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DGWBC_RS01675	COG4589	Belongs to the CDS family
DGWBC_RS01680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DGWBC_RS01695	COG0254	rRNA binding
DGWBC_RS01710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DGWBC_RS01715	COG0047	phosphoribosylformylglycinamidine synthase activity
DGWBC_RS01725	COG4166	transmembrane transport
DGWBC_RS01735	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DGWBC_RS01740	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DGWBC_RS01745	COG4651	solute:proton antiporter activity
DGWBC_RS01745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGWBC_RS01760	COG0799	negative regulation of ribosome biogenesis
DGWBC_RS01780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGWBC_RS01785	COG1862	Preprotein translocase
DGWBC_RS01790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DGWBC_RS01800	COG2199	diguanylate cyclase activity
DGWBC_RS01800	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DGWBC_RS01860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DGWBC_RS01870	COG2827	Endonuclease containing a URI domain
DGWBC_RS01895	COG4895	conserved protein (DUF2196)
DGWBC_RS01900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DGWBC_RS01915	COG0477	Major facilitator Superfamily
DGWBC_RS01925	COG0736	holo-[acyl-carrier-protein] synthase activity
DGWBC_RS01950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DGWBC_RS01970	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS02010	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS02020	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS02025	COG2205	protein histidine kinase activity
DGWBC_RS02045	COG0717	Belongs to the dCTP deaminase family
DGWBC_RS02070	COG4584	PFAM Integrase catalytic
DGWBC_RS02075	COG1484	DNA-dependent DNA replication
DGWBC_RS02085	COG2801	Transposase and inactivated derivatives
DGWBC_RS02105	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DGWBC_RS02120	COG2801	Transposase and inactivated derivatives
DGWBC_RS02145	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DGWBC_RS02160	COG0519	Catalyzes the synthesis of GMP from XMP
DGWBC_RS02185	COG0709	Synthesizes selenophosphate from selenide and ATP
DGWBC_RS02190	COG0352	thiamine-phosphate diphosphorylase activity
DGWBC_RS02210	COG0180	Tryptophanyl-tRNA synthetase
DGWBC_RS02215	COG0788	formyltetrahydrofolate deformylase activity
DGWBC_RS02230	COG0436	Aminotransferase
DGWBC_RS02235	COG1522	sequence-specific DNA binding
DGWBC_RS02265	COG2361	Protein of unknown function DUF86
DGWBC_RS02275	COG0653	protein targeting
DGWBC_RS02290	COG1028	Short-chain dehydrogenase reductase Sdr
DGWBC_RS02300	COG0287	Prephenate dehydrogenase
DGWBC_RS02300	COG1605	Chorismate mutase
DGWBC_RS02305	COG0077	Prephenate dehydratase
DGWBC_RS02305	COG1605	Chorismate mutase
DGWBC_RS02320	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DGWBC_RS02325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DGWBC_RS02340	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DGWBC_RS02375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DGWBC_RS02385	COG0089	rRNA binding
DGWBC_RS02390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DGWBC_RS02410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DGWBC_RS02415	COG0255	Belongs to the universal ribosomal protein uL29 family
DGWBC_RS02425	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DGWBC_RS02445	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DGWBC_RS02455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DGWBC_RS02460	COG1841	ribosomal large subunit assembly
DGWBC_RS02470	COG0201	protein transport
DGWBC_RS02475	COG0563	adenylate kinase activity
DGWBC_RS02495	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DGWBC_RS02505	COG0202	RNA polymerase activity
DGWBC_RS02515	COG0101	tRNA pseudouridine synthase activity
DGWBC_RS02530	COG2222	sugar isomerase
DGWBC_RS02535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGWBC_RS02545	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DGWBC_RS02565	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DGWBC_RS02580	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DGWBC_RS02595	COG0730	response to heat
DGWBC_RS02600	COG0598	Magnesium transport protein CorA
DGWBC_RS02615	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DGWBC_RS02615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DGWBC_RS02620	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DGWBC_RS02630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DGWBC_RS02640	COG2205	protein histidine kinase activity
DGWBC_RS02645	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS02675	COG0488	(ABC) transporter
DGWBC_RS02690	COG0589	response to stress
DGWBC_RS02695	COG0556	nucleotide-excision repair
DGWBC_RS02715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DGWBC_RS02720	COG1120	ATPase activity
DGWBC_RS02735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGWBC_RS02745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGWBC_RS02750	COG0681	Belongs to the peptidase S26 family
DGWBC_RS02755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DGWBC_RS02810	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DGWBC_RS02820	COG5002	protein histidine kinase activity
DGWBC_RS02825	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS02880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DGWBC_RS02895	COG0133	tryptophan synthase activity
DGWBC_RS02900	COG0159	tryptophan synthase activity
DGWBC_RS02920	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DGWBC_RS02925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DGWBC_RS02945	COG2205	protein histidine kinase activity
DGWBC_RS02950	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS02960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGWBC_RS02965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DGWBC_RS03010	COG0347	Belongs to the P(II) protein family
DGWBC_RS03015	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
DGWBC_RS03020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DGWBC_RS03060	COG0420	3'-5' exonuclease activity
DGWBC_RS03065	COG4717	serine-type aminopeptidase activity
DGWBC_RS03095	COG0328	RNA-DNA hybrid ribonuclease activity
DGWBC_RS03175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DGWBC_RS03175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DGWBC_RS03185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGWBC_RS03185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DGWBC_RS03190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DGWBC_RS03210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DGWBC_RS03220	COG3209	COG3209 Rhs family protein
DGWBC_RS03275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DGWBC_RS03280	COG0460	homoserine dehydrogenase
DGWBC_RS03285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DGWBC_RS03325	COG1980	fructose-bisphosphate aldolase activity
DGWBC_RS03330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DGWBC_RS03335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DGWBC_RS03340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DGWBC_RS03345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DGWBC_RS03350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGWBC_RS03355	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS03360	COG2205	protein histidine kinase activity
DGWBC_RS03365	COG0456	acetyltransferase
DGWBC_RS03370	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGWBC_RS03375	COG1181	Belongs to the D-alanine--D-alanine ligase family
DGWBC_RS03400	COG1971	Probably functions as a manganese efflux pump
DGWBC_RS03415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DGWBC_RS03420	COG0067	glutamate synthase
DGWBC_RS03425	COG0107	imidazoleglycerol-phosphate synthase activity
DGWBC_RS03430	COG0069	glutamate synthase activity
DGWBC_RS03440	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS03455	COG0004	ammonium transporteR
DGWBC_RS03460	COG0347	Belongs to the P(II) protein family
DGWBC_RS03475	COG3769	mannosylglycerate metabolic process
DGWBC_RS03485	COG0174	glutamine synthetase
DGWBC_RS03490	COG2409	Drug exporters of the RND superfamily
DGWBC_RS03500	COG2197	response regulator
DGWBC_RS03505	COG4585	Histidine kinase
DGWBC_RS03525	COG1335	isochorismatase
DGWBC_RS03545	COG1131	(ABC) transporter
DGWBC_RS03555	COG0697	spore germination
DGWBC_RS03560	COG0497	DNA recombination
DGWBC_RS03590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DGWBC_RS03605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DGWBC_RS03610	COG0481	GTPase activity
DGWBC_RS03620	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DGWBC_RS03630	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DGWBC_RS03635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DGWBC_RS03650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DGWBC_RS03655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGWBC_RS03660	COG0589	response to stress
DGWBC_RS03675	COG0356	it plays a direct role in the translocation of protons across the membrane
DGWBC_RS03690	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DGWBC_RS03705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DGWBC_RS03710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DGWBC_RS03720	COG0228	four-way junction DNA binding
DGWBC_RS03730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DGWBC_RS03740	COG0747	negative chemotaxis
DGWBC_RS03750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DGWBC_RS03765	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DGWBC_RS03780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DGWBC_RS03780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DGWBC_RS03795	COG1217	gtp-binding protein TYPA
DGWBC_RS03800	COG1193	negative regulation of DNA recombination
DGWBC_RS03840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DGWBC_RS03845	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DGWBC_RS03855	COG0131	Imidazoleglycerol-phosphate dehydratase
DGWBC_RS03860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DGWBC_RS03865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DGWBC_RS03870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DGWBC_RS03875	COG0151	Belongs to the GarS family
DGWBC_RS03890	COG0009	L-threonylcarbamoyladenylate synthase
DGWBC_RS03895	COG0698	ribose 5-phosphate isomerase
DGWBC_RS03905	COG0028	Belongs to the TPP enzyme family
DGWBC_RS03910	COG0440	acetolactate synthase activity
DGWBC_RS03920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DGWBC_RS03925	COG1285	pathogenesis
DGWBC_RS03930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DGWBC_RS03935	COG0066	3-isopropylmalate dehydratase activity
DGWBC_RS03940	COG0473	3-isopropylmalate dehydrogenase activity
DGWBC_RS03945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DGWBC_RS03985	COG1032	radical SAM domain protein
DGWBC_RS04000	COG0719	Fe-S assembly protein
DGWBC_RS04005	COG0396	ATPase activity
DGWBC_RS04025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DGWBC_RS04040	COG0006	proline dipeptidase activity
DGWBC_RS04045	COG4974	Belongs to the 'phage' integrase family
DGWBC_RS04050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DGWBC_RS04055	COG0758	DNA mediated transformation
DGWBC_RS04060	COG0019	diaminopimelate decarboxylase activity
DGWBC_RS04070	COG1774	PSP1 C-terminal conserved region
DGWBC_RS04090	COG0305	Participates in initiation and elongation during chromosome replication
DGWBC_RS04095	COG0359	binds to the 23S rRNA
DGWBC_RS04115	COG1473	amidohydrolase
DGWBC_RS04130	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DGWBC_RS04145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DGWBC_RS04150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DGWBC_RS04155	COG0436	Aminotransferase
DGWBC_RS04160	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DGWBC_RS04165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DGWBC_RS04175	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DGWBC_RS04180	COG0126	phosphoglycerate kinase activity
DGWBC_RS04210	COG0784	Response regulator, receiver
DGWBC_RS04215	COG2202	Pas domain
DGWBC_RS04215	COG2205	protein histidine kinase activity
DGWBC_RS04240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DGWBC_RS04245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DGWBC_RS04300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DGWBC_RS04310	COG0242	peptide deformylase activity
DGWBC_RS04345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DGWBC_RS04385	COG0714	Associated with various cellular activities
DGWBC_RS04400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DGWBC_RS04405	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DGWBC_RS04415	COG0673	inositol 2-dehydrogenase activity
DGWBC_RS04470	COG2337	Toxic component of a toxin-antitoxin (TA) module
DGWBC_RS04510	COG1797	cobyrinic acid a,c-diamide synthase activity
DGWBC_RS04515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DGWBC_RS04535	COG0671	phosphoesterase, PA-phosphatase related
DGWBC_RS04545	COG0419	ATPase involved in DNA repair
DGWBC_RS04555	COG2267	carboxylic ester hydrolase activity
DGWBC_RS04565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DGWBC_RS04570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DGWBC_RS04580	COG0598	Magnesium transport protein CorA
DGWBC_RS04605	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGWBC_RS04610	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGWBC_RS04615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGWBC_RS04620	COG0649	NAD binding
DGWBC_RS04645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DGWBC_RS04650	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGWBC_RS04660	COG0084	hydrolase, TatD family'
DGWBC_RS04665	COG2801	Transposase and inactivated derivatives
DGWBC_RS04680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DGWBC_RS04705	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DGWBC_RS04730	COG1022	Amp-dependent synthetase and ligase
DGWBC_RS04745	COG4993	Dehydrogenase
DGWBC_RS04745	COG2010	Cytochrome c
DGWBC_RS04750	COG0594	ribonuclease P activity
DGWBC_RS04755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DGWBC_RS04780	COG0628	permease
DGWBC_RS04785	COG1295	ribonuclease BN
DGWBC_RS04815	COG0698	ribose 5-phosphate isomerase
DGWBC_RS04855	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DGWBC_RS04860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DGWBC_RS04870	COG0318	PFAM AMP-dependent synthetase and ligase
DGWBC_RS04875	COG0571	ribonuclease III activity
DGWBC_RS04885	COG0746	molybdenum cofactor guanylyltransferase activity
DGWBC_RS04905	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DGWBC_RS04925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGWBC_RS04945	COG1126	abc transporter atp-binding protein
DGWBC_RS04950	COG0765	amino acid transport
DGWBC_RS04955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DGWBC_RS04960	COG1132	(ABC) transporter
DGWBC_RS04990	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS04995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DGWBC_RS05000	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DGWBC_RS05000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DGWBC_RS05005	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DGWBC_RS05015	COG1205	dead DEAH box helicase
DGWBC_RS05015	COG1111	helicase
DGWBC_RS05035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DGWBC_RS05070	COG1013	pyruvate-flavodoxin oxidoreductase activity
DGWBC_RS05075	COG0674	pyruvate-flavodoxin oxidoreductase activity
DGWBC_RS05095	COG0475	glutathione-regulated potassium exporter activity
DGWBC_RS05105	COG2827	Endonuclease containing a URI domain
DGWBC_RS05120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DGWBC_RS05120	COG0574	Belongs to the PEP-utilizing enzyme family
DGWBC_RS05125	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DGWBC_RS05130	COG0358	DNA primase activity
DGWBC_RS05175	COG2197	response regulator
DGWBC_RS05185	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DGWBC_RS05210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DGWBC_RS05220	COG2205	protein histidine kinase activity
DGWBC_RS05240	COG0517	IMP dehydrogenase activity
DGWBC_RS05240	COG1994	Peptidase M50
DGWBC_RS05250	COG1994	Peptidase M50
DGWBC_RS05250	COG0517	IMP dehydrogenase activity
DGWBC_RS05255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DGWBC_RS05265	COG3854	ATPases associated with a variety of cellular activities
DGWBC_RS05270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DGWBC_RS05275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DGWBC_RS05280	COG0792	nuclease activity
DGWBC_RS05285	COG0352	thiamine-phosphate diphosphorylase activity
DGWBC_RS05295	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DGWBC_RS05300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DGWBC_RS05320	COG0423	glycine-tRNA ligase activity
DGWBC_RS05325	COG0420	3'-5' exonuclease activity
DGWBC_RS05330	COG1187	pseudouridine synthase activity
DGWBC_RS05340	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DGWBC_RS05345	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DGWBC_RS05355	COG1131	(ABC) transporter
DGWBC_RS05365	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DGWBC_RS05380	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DGWBC_RS05390	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DGWBC_RS05395	COG2211	Major facilitator Superfamily
DGWBC_RS05400	COG0196	riboflavin kinase activity
DGWBC_RS05415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DGWBC_RS05440	COG1260	myo-inositol-1-phosphate synthase
DGWBC_RS05445	COG0438	transferase activity, transferring glycosyl groups
DGWBC_RS05450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DGWBC_RS05455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DGWBC_RS05465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DGWBC_RS05470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DGWBC_RS05480	COG1185	polyribonucleotide nucleotidyltransferase activity
DGWBC_RS05510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DGWBC_RS05515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DGWBC_RS05520	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DGWBC_RS05525	COG0195	Participates in both transcription termination and antitermination
DGWBC_RS05545	COG0798	PFAM Bile acid sodium symporter
DGWBC_RS05560	COG4608	Belongs to the ABC transporter superfamily
DGWBC_RS05565	COG0444	Belongs to the ABC transporter superfamily
DGWBC_RS05570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DGWBC_RS05575	COG0601	transmembrane transport
DGWBC_RS05580	COG0747	negative chemotaxis
DGWBC_RS05590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DGWBC_RS05595	COG2890	protein-(glutamine-N5) methyltransferase activity
DGWBC_RS05605	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DGWBC_RS05610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DGWBC_RS05625	COG4974	Belongs to the 'phage' integrase family
DGWBC_RS05665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DGWBC_RS05705	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS05710	COG5002	protein histidine kinase activity
DGWBC_RS05730	COG0577	efflux transmembrane transporter activity
DGWBC_RS05735	COG1136	(ABC) transporter
DGWBC_RS05745	COG1131	(ABC) transporter
DGWBC_RS05750	COG1695	Transcriptional regulator
DGWBC_RS05765	COG0592	DNA-directed DNA polymerase activity
DGWBC_RS05780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DGWBC_RS05820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGWBC_RS05840	COG0540	Belongs to the ATCase OTCase family
DGWBC_RS05845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DGWBC_RS05850	COG0505	Belongs to the CarA family
DGWBC_RS05855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DGWBC_RS05860	COG0543	2 iron, 2 sulfur cluster binding
DGWBC_RS05865	COG2081	HI0933 family
DGWBC_RS05870	COG0205	6-phosphofructokinase activity
DGWBC_RS05885	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS05890	COG2211	Major facilitator Superfamily
DGWBC_RS05900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DGWBC_RS05910	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DGWBC_RS05915	COG1017	nitric oxide dioxygenase activity
DGWBC_RS05915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DGWBC_RS05920	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DGWBC_RS05925	COG3259	Nickel-dependent hydrogenase
DGWBC_RS05940	COG1461	Dihydroxyacetone kinase
DGWBC_RS05950	COG1307	EDD domain protein, DegV family
DGWBC_RS05955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DGWBC_RS05970	COG1960	acyl-CoA dehydrogenase activity
DGWBC_RS05975	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DGWBC_RS05985	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DGWBC_RS05990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DGWBC_RS05995	COG1028	Short-chain dehydrogenase reductase Sdr
DGWBC_RS06020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DGWBC_RS06025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DGWBC_RS06035	COG1546	Belongs to the CinA family
DGWBC_RS06035	COG1058	Belongs to the CinA family
DGWBC_RS06045	COG1872	DUF167
DGWBC_RS06055	COG2204	response regulator
DGWBC_RS06065	COG1993	acr, cog1993
DGWBC_RS06070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DGWBC_RS06080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DGWBC_RS06090	COG0778	Nitroreductase
DGWBC_RS06130	COG1028	Short-chain dehydrogenase reductase Sdr
DGWBC_RS06150	COG0222	ribosome binding
DGWBC_RS06170	COG0250	Participates in transcription elongation, termination and antitermination
DGWBC_RS06175	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DGWBC_RS06180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DGWBC_RS06210	COG0438	transferase activity, transferring glycosyl groups
DGWBC_RS06220	COG2205	protein histidine kinase activity
DGWBC_RS06225	COG0745	RESPONSE REGULATOR receiver
DGWBC_RS06240	COG1333	cytochrome c biogenesis protein
DGWBC_RS06245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DGWBC_RS06250	COG1832	CoA-binding protein
DGWBC_RS06255	COG1013	pyruvate-flavodoxin oxidoreductase activity
DGWBC_RS06260	COG0674	pyruvate-flavodoxin oxidoreductase activity
DGWBC_RS06260	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DGWBC_RS06295	COG4176	ABC-type proline glycine betaine transport system permease component
DGWBC_RS06335	COG0312	modulator of DNA gyrase
DGWBC_RS06365	COG0535	radical SAM domain protein
DGWBC_RS06395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DGWBC_RS06400	COG0494	nUDIX hydrolase
DGWBC_RS06410	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DGWBC_RS06420	COG0537	adenosine 5'-monophosphoramidase activity
DGWBC_RS06440	COG0473	3-isopropylmalate dehydrogenase activity
DGWBC_RS06445	COG0066	3-isopropylmalate dehydratase activity
DGWBC_RS06455	COG0511	ligase activity, forming carbon-carbon bonds
DGWBC_RS06455	COG5016	pyruvate
DGWBC_RS06460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DGWBC_RS06470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DGWBC_RS06475	COG2078	PFAM AMMECR1 domain protein
DGWBC_RS06475	COG3885	ferrous iron binding
DGWBC_RS06485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DGWBC_RS06495	COG0052	Belongs to the universal ribosomal protein uS2 family
DGWBC_RS06500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DGWBC_RS06505	COG0528	UMP kinase activity
DGWBC_RS06515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DGWBC_RS06535	COG1695	Transcriptional regulator
DGWBC_RS06550	COG0251	oxidation-reduction process
DGWBC_RS06570	COG0525	valine-tRNA ligase activity
DGWBC_RS06585	COG0154	amidase activity
DGWBC_RS06590	COG1363	Peptidase, m42
DGWBC_RS06595	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DGWBC_RS06600	COG1573	uracil-dna glycosylase
DGWBC_RS06640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DGWBC_RS06645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DGWBC_RS06655	COG0140	phosphoribosyl-ATP diphosphatase activity
DGWBC_RS06655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DGWBC_RS06770	COG2197	response regulator
DGWBC_RS06800	COG2181	nitrate reductase activity
DGWBC_RS06800	COG0247	lactate metabolic process
DGWBC_RS06810	COG3118	belongs to the thioredoxin family
DGWBC_RS06815	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
DGWBC_RS06820	COG0588	phosphoglycerate mutase activity
DGWBC_RS06825	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DGWBC_RS06835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DGWBC_RS06840	COG1063	alcohol dehydrogenase
DGWBC_RS06845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DGWBC_RS06860	COG1120	ATPase activity
DGWBC_RS06865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DGWBC_RS06870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DGWBC_RS06890	COG3259	Nickel-dependent hydrogenase
DGWBC_RS06895	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
DGWBC_RS06930	COG2226	methyltransferase
DGWBC_RS06945	COG0456	acetyltransferase
DGWBC_RS06950	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DGWBC_RS06990	COG2326	polyphosphate kinase activity
DGWBC_RS07000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DGWBC_RS07025	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DGWBC_RS07035	COG1131	(ABC) transporter
DGWBC_RS07050	COG1597	lipid kinase activity
DGWBC_RS07055	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DGWBC_RS07060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DGWBC_RS07070	COG0516	GMP reductase activity
DGWBC_RS07115	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DGWBC_RS07135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DGWBC_RS07155	COG0105	UTP biosynthetic process
DGWBC_RS07160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DGWBC_RS07165	COG0802	atpase or kinase
DGWBC_RS07170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DGWBC_RS07185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DGWBC_RS07205	COG2217	Heavy metal translocating P-type atpase
DGWBC_RS07210	COG2217	Heavy metal translocating P-type atpase
DGWBC_RS07220	COG0586	Pfam SNARE associated Golgi protein
DGWBC_RS07230	COG3383	formate dehydrogenase (NAD+) activity
DGWBC_RS07260	COG1193	negative regulation of DNA recombination
DGWBC_RS07280	COG2197	response regulator
DGWBC_RS07285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DGWBC_RS07290	COG1459	type II secretion system
DGWBC_RS07365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DGWBC_RS07395	COG0493	'glutamate synthase
DGWBC_RS07395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DGWBC_RS07440	COG2197	response regulator
DGWBC_RS07475	COG1704	LemA family
DGWBC_RS07480	COG0501	Belongs to the peptidase M48B family
DGWBC_RS07485	COG0513	Belongs to the DEAD box helicase family
DGWBC_RS07500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DGWBC_RS07525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DGWBC_RS07530	COG1592	Rubrerythrin
DGWBC_RS07540	COG0753	catalase activity
DGWBC_RS07550	COG1918	ferrous iron import across plasma membrane
DGWBC_RS07550	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DGWBC_RS07575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DGWBC_RS07580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DGWBC_RS07585	COG0742	ribosomal rna small subunit methyltransferase
DGWBC_RS07650	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DGWBC_RS07660	COG0542	response to heat
DGWBC_RS07725	COG2226	methyltransferase
DGWBC_RS07730	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DGWBC_RS07735	COG1324	tolerance protein
DGWBC_RS07740	COG1045	serine acetyltransferase
DGWBC_RS07750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DGWBC_RS07750	COG1918	ferrous iron import across plasma membrane
DGWBC_RS07795	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DGWBC_RS07800	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
DGWBC_RS07805	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
DGWBC_RS07825	COG2197	response regulator
DGWBC_RS07855	COG1307	EDD domain protein, DegV family
DGWBC_RS07900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DGWBC_RS07910	COG0737	Belongs to the 5'-nucleotidase family
DGWBC_RS07980	COG0336	Belongs to the RNA methyltransferase TrmD family
DGWBC_RS07985	COG0335	large ribosomal subunit rRNA binding
DGWBC_RS07990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DGWBC_RS07995	COG0617	tRNA 3'-terminal CCA addition
DGWBC_RS08000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DGWBC_RS08005	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DGWBC_RS08030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DGWBC_RS08040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DGWBC_RS08050	COG0504	CTP synthase activity
DGWBC_RS08055	COG3260	NADH ubiquinone oxidoreductase 20
DGWBC_RS08060	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
DGWBC_RS08060	COG3261	NADH dehydrogenase
DGWBC_RS08065	COG0651	ATP synthesis coupled electron transport
DGWBC_RS08075	COG0650	Formate hydrogenlyase subunit 4
DGWBC_RS08080	COG0651	ATP synthesis coupled electron transport
DGWBC_RS08085	COG0542	response to heat
DGWBC_RS08100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DGWBC_RS08145	COG0406	alpha-ribazole phosphatase activity
DGWBC_RS08150	COG0501	Belongs to the peptidase M48B family
DGWBC_RS08160	COG1253	flavin adenine dinucleotide binding
DGWBC_RS08180	COG0298	carbon dioxide binding
DGWBC_RS08185	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DGWBC_RS08195	COG0375	protein maturation
DGWBC_RS08205	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DGWBC_RS08210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DGWBC_RS08215	COG0612	Peptidase, M16
DGWBC_RS08230	COG2095	MarC family integral membrane protein
DGWBC_RS08240	COG1309	transcriptional regulator
DGWBC_RS08285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DGWBC_RS08290	COG4152	abc transporter atp-binding protein
DGWBC_RS08305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DGWBC_RS08360	COG1342	Belongs to the UPF0251 family
DGWBC_RS08395	COG2852	Protein conserved in bacteria
DGWBC_RS08415	COG0003	Pfam Anion-transporting ATPase
DGWBC_RS08445	COG0488	(ABC) transporter
DGWBC_RS08450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DGWBC_RS08455	COG1032	radical SAM domain protein
DGWBC_RS08460	COG0655	NAD(P)H dehydrogenase (quinone) activity
DGWBC_RS08470	COG0077	Prephenate dehydratase
DGWBC_RS08470	COG1605	Chorismate mutase
DGWBC_RS08475	COG2197	response regulator
DGWBC_RS08480	COG4585	Histidine kinase
DGWBC_RS08505	COG0709	Synthesizes selenophosphate from selenide and ATP
DGWBC_RS08510	COG1921	L-seryl-tRNASec selenium transferase activity
DGWBC_RS08530	COG0493	'glutamate synthase
DGWBC_RS08530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DGWBC_RS08560	COG0805	protein transport
DGWBC_RS08565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DGWBC_RS08580	COG4372	Transposase
DGWBC_RS08580	COG1418	mRNA catabolic process
DGWBC_RS08590	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DGWBC_RS08615	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DGWBC_RS08620	COG1122	ATPase activity
DGWBC_RS08625	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DGWBC_RS08630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DGWBC_RS08635	COG2738	Putative neutral zinc metallopeptidase
DGWBC_RS08715	COG5002	protein histidine kinase activity
DGWBC_RS08720	COG4251	negative regulation of phosphorylation
DGWBC_RS08775	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
DGWBC_RS08780	COG4191	Histidine kinase
DGWBC_RS08790	COG2205	protein histidine kinase activity
DGWBC_RS08810	COG3209	COG3209 Rhs family protein
DGWBC_RS08860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DGWBC_RS08885	COG3852	Histidine kinase
DGWBC_RS08895	COG3420	alginic acid biosynthetic process
DGWBC_RS08915	COG3852	Histidine kinase