locus-tag	class	description
SU48_RS00005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SU48_RS00015	COG4133	protoheme IX ABC transporter activity
SU48_RS00030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SU48_RS00035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SU48_RS00040	COG0740	serine-type endopeptidase activity
SU48_RS00045	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SU48_RS00050	COG0745	RESPONSE REGULATOR receiver
SU48_RS00055	COG4251	negative regulation of phosphorylation
SU48_RS00060	COG0784	Response regulator, receiver
SU48_RS00075	COG2311	Membrane
SU48_RS00080	COG0217	transcriptional regulatory protein
SU48_RS00090	COG0745	RESPONSE REGULATOR receiver
SU48_RS00095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SU48_RS00105	COG2315	Protein conserved in bacteria
SU48_RS00125	COG2897	thiosulfate sulfurtransferase activity
SU48_RS00150	COG0557	exoribonuclease II activity
SU48_RS00190	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SU48_RS00195	COG1363	Peptidase, m42
SU48_RS00200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SU48_RS00205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SU48_RS00220	COG1024	Enoyl-CoA hydratase
SU48_RS00225	COG1028	Short-chain dehydrogenase reductase Sdr
SU48_RS00230	COG2027	D-alanyl-D-alanine carboxypeptidase
SU48_RS00235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SU48_RS00250	COG0803	Belongs to the bacterial solute-binding protein 9 family
SU48_RS00280	COG2226	methyltransferase
SU48_RS00285	COG4221	oxidoreductase activity
SU48_RS00300	COG1609	Transcriptional regulator
SU48_RS00310	COG0738	Major facilitator superfamily
SU48_RS00315	COG2326	polyphosphate kinase activity
SU48_RS00335	COG1854	S-ribosylhomocysteine lyase activity
SU48_RS00340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SU48_RS00345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SU48_RS00355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SU48_RS00360	COG0083	homoserine kinase activity
SU48_RS00390	COG1213	nucleotidyl transferase
SU48_RS00390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SU48_RS00405	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
SU48_RS00410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SU48_RS00425	COG0758	DNA mediated transformation
SU48_RS00440	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SU48_RS00445	COG0592	DNA-directed DNA polymerase activity
SU48_RS00450	COG0148	phosphopyruvate hydratase activity
SU48_RS00455	COG0469	pyruvate kinase activity
SU48_RS00460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SU48_RS00470	COG0101	tRNA pseudouridine synthase activity
SU48_RS00475	COG0739	heme binding
SU48_RS00490	COG0114	fumarate hydratase activity
SU48_RS00495	COG0492	ferredoxin-NADP+ reductase activity
SU48_RS00500	COG2720	vancomycin resistance protein
SU48_RS00505	COG1475	DNA binding
SU48_RS00510	COG1192	Involved in chromosome partitioning
SU48_RS00515	COG0357	Ribosomal RNA small subunit methyltransferase G
SU48_RS00525	COG0445	tRNA wobble uridine modification
SU48_RS00535	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SU48_RS00540	COG0022	dehydrogenase e1 component
SU48_RS00550	COG0508	dehydrogenase complex catalyzes the overall conversion of
SU48_RS00555	COG1028	Short-chain dehydrogenase reductase Sdr
SU48_RS00565	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
SU48_RS00590	COG1960	acyl-CoA dehydrogenase activity
SU48_RS00600	COG1247	-acetyltransferase
SU48_RS00605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SU48_RS00620	COG1428	Deoxynucleoside kinase
SU48_RS00625	COG1428	Deoxynucleoside kinase
SU48_RS00635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SU48_RS00645	COG2843	Capsule synthesis protein
SU48_RS00710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SU48_RS00715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SU48_RS00720	COG1438	arginine binding
SU48_RS00725	COG5002	protein histidine kinase activity
SU48_RS00750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SU48_RS00765	COG0473	3-isopropylmalate dehydrogenase activity
SU48_RS00770	COG0288	reversible hydration of carbon dioxide
SU48_RS00780	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SU48_RS00785	COG2860	membrane
SU48_RS00795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SU48_RS00800	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SU48_RS00805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SU48_RS00825	COG1174	glycine betaine transport
SU48_RS00835	COG1174	glycine betaine transport
SU48_RS00840	COG1732	Glycine betaine
SU48_RS00845	COG0776	regulation of translation
SU48_RS00850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SU48_RS00885	COG1058	Belongs to the CinA family
SU48_RS00885	COG1546	Belongs to the CinA family
SU48_RS00890	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SU48_RS00895	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SU48_RS00900	COG1268	BioY protein
SU48_RS00905	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SU48_RS00905	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SU48_RS00910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SU48_RS00915	COG0135	phosphoribosylanthranilate isomerase activity
SU48_RS00925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SU48_RS00945	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SU48_RS00955	COG1595	DNA-templated transcription, initiation
SU48_RS01015	COG2321	neutral zinc metallopeptidase
SU48_RS01035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SU48_RS01065	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SU48_RS01065	COG0456	acetyltransferase
SU48_RS01075	COG1233	COG1233 Phytoene dehydrogenase and related
SU48_RS01115	COG3437	response regulator, receiver
SU48_RS01115	COG2770	Histidine kinase
SU48_RS01125	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SU48_RS01130	COG0163	prenyltransferase activity
SU48_RS01165	COG0596	Alpha beta hydrolase
SU48_RS01180	COG0531	amino acid
SU48_RS01200	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SU48_RS01205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SU48_RS01215	COG0047	phosphoribosylformylglycinamidine synthase activity
SU48_RS01225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SU48_RS01235	COG2890	protein-(glutamine-N5) methyltransferase activity
SU48_RS01240	COG1847	R3H domain protein
SU48_RS01245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SU48_RS01250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SU48_RS01255	COG2309	aminopeptidase activity
SU48_RS01260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SU48_RS01265	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SU48_RS01275	COG1051	belongs to the nudix hydrolase family
SU48_RS01290	COG0242	peptide deformylase activity
SU48_RS01295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SU48_RS01310	COG1758	RNA polymerase activity
SU48_RS01320	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SU48_RS01335	COG0860	N-Acetylmuramoyl-L-alanine amidase
SU48_RS01340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SU48_RS01350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SU48_RS01355	COG0765	amino acid transport
SU48_RS01375	COG3191	aminopeptidase activity
SU48_RS01380	COG0745	RESPONSE REGULATOR receiver
SU48_RS01390	COG5001	Diguanylate cyclase
SU48_RS01390	COG3706	GGDEF domain
SU48_RS01390	COG2203	Gaf domain
SU48_RS01390	COG4251	negative regulation of phosphorylation
SU48_RS01395	COG0567	Dehydrogenase, E1 component
SU48_RS01415	COG3842	ATPase activity
SU48_RS01425	COG1840	ABC-type Fe3 transport system, periplasmic component
SU48_RS01430	COG1181	Belongs to the D-alanine--D-alanine ligase family
SU48_RS01435	COG0747	negative chemotaxis
SU48_RS01440	COG0601	transmembrane transport
SU48_RS01445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SU48_RS01450	COG0354	folic acid binding
SU48_RS01455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SU48_RS01460	COG1648	precorrin-2 dehydrogenase activity
SU48_RS01460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SU48_RS01475	COG1324	tolerance protein
SU48_RS01500	COG2309	aminopeptidase activity
SU48_RS01520	COG2313	pseudouridylate synthase activity
SU48_RS01525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SU48_RS01600	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SU48_RS01620	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SU48_RS01725	COG0587	DNA-directed DNA polymerase activity
SU48_RS01730	COG1028	Short-chain dehydrogenase reductase Sdr
SU48_RS01735	COG2816	NAD+ diphosphatase activity
SU48_RS01740	COG1116	anion transmembrane transporter activity
SU48_RS01745	COG0697	spore germination
SU48_RS01755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SU48_RS01770	COG0285	dihydrofolate synthase activity
SU48_RS01775	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SU48_RS01785	COG2720	vancomycin resistance protein
SU48_RS01790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SU48_RS01810	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SU48_RS01815	COG1280	lysine exporter protein (LysE YggA)
SU48_RS01830	COG0484	heat shock protein binding
SU48_RS01835	COG4628	conserved protein (DUF2132)
SU48_RS01840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SU48_RS01845	COG0443	Heat shock 70 kDa protein
SU48_RS01850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SU48_RS01860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SU48_RS01870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SU48_RS01875	COG3706	GGDEF domain
SU48_RS01880	COG1279	arginine transmembrane transporter activity
SU48_RS01900	COG0137	argininosuccinate synthase activity
SU48_RS01920	COG0165	Argininosuccinate lyase
SU48_RS01940	COG1444	tRNA N-acetyltransferase activity
SU48_RS01955	COG0505	Belongs to the CarA family
SU48_RS01985	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SU48_RS01995	COG1304	FMN binding
SU48_RS02010	COG0193	aminoacyl-tRNA hydrolase activity
SU48_RS02020	COG0347	Belongs to the P(II) protein family
SU48_RS02035	COG1269	ATP hydrolysis coupled proton transport
SU48_RS02045	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
SU48_RS02050	COG1527	subunit (C
SU48_RS02055	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SU48_RS02060	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SU48_RS02065	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SU48_RS02070	COG1394	ATPase activity, coupled to movement of substances
SU48_RS02080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SU48_RS02085	COG2226	methyltransferase
SU48_RS02095	COG2165	general secretion pathway protein
SU48_RS02100	COG0305	Participates in initiation and elongation during chromosome replication
SU48_RS02115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SU48_RS02165	COG2963	transposase activity
SU48_RS02200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SU48_RS02205	COG0802	atpase or kinase
SU48_RS02210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SU48_RS02215	COG0280	phosphate acetyltransferase
SU48_RS02215	COG0857	belongs to the CobB CobQ family
SU48_RS02255	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SU48_RS02270	COG0642	Histidine kinase
SU48_RS02275	COG0745	RESPONSE REGULATOR receiver
SU48_RS02290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SU48_RS02295	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SU48_RS02300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SU48_RS02305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SU48_RS02310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SU48_RS02315	COG0612	Peptidase, M16
SU48_RS02335	COG1522	sequence-specific DNA binding
SU48_RS02350	COG0194	GDP metabolic process
SU48_RS02355	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SU48_RS02360	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SU48_RS02385	COG0084	hydrolase, TatD family'
SU48_RS02390	COG1960	acyl-CoA dehydrogenase activity
SU48_RS02395	COG0598	Magnesium transport protein CorA
SU48_RS02400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SU48_RS02405	COG1570	exodeoxyribonuclease VII activity
SU48_RS02415	COG1418	mRNA catabolic process
SU48_RS02420	COG1506	peptidase
SU48_RS02425	COG0359	binds to the 23S rRNA
SU48_RS02430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SU48_RS02435	COG0629	single-stranded DNA binding
SU48_RS02440	COG0360	Binds together with S18 to 16S ribosomal RNA
SU48_RS02460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SU48_RS02475	COG2856	Zn peptidase
SU48_RS02480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SU48_RS02505	COG1185	polyribonucleotide nucleotidyltransferase activity
SU48_RS02510	COG0243	molybdopterin cofactor binding
SU48_RS02530	COG2255	four-way junction helicase activity
SU48_RS02545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SU48_RS02550	COG1845	cytochrome c oxidase, subunit III
SU48_RS02550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SU48_RS02560	COG0109	protoheme IX farnesyltransferase activity
SU48_RS02565	COG0109	protoheme IX farnesyltransferase activity
SU48_RS02565	COG1612	heme a metabolic process
SU48_RS02580	COG5001	Diguanylate cyclase
SU48_RS02585	COG2322	membrane
SU48_RS02590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SU48_RS02615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SU48_RS02625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SU48_RS02630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SU48_RS02635	COG0793	Belongs to the peptidase S41A family
SU48_RS02645	COG2197	response regulator
SU48_RS02660	COG0658	competence protein
SU48_RS02660	COG2333	competence protein COMEC
SU48_RS02665	COG0039	L-malate dehydrogenase activity
SU48_RS02695	COG1024	Enoyl-CoA hydratase
SU48_RS02700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SU48_RS02705	COG0318	PFAM AMP-dependent synthetase and ligase
SU48_RS02770	COG1091	dTDP-4-dehydrorhamnose reductase activity
SU48_RS02805	COG0667	Aldo Keto reductase
SU48_RS02815	COG1131	(ABC) transporter
SU48_RS02835	COG0395	ABC-type sugar transport system, permease component
SU48_RS02840	COG1175	transmembrane transport
SU48_RS02850	COG1609	Transcriptional regulator
SU48_RS02855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SU48_RS02875	COG0300	oxidoreductase activity
SU48_RS02885	COG0557	exoribonuclease II activity
SU48_RS02890	COG0708	Exodeoxyribonuclease III
SU48_RS02910	COG0439	Biotin carboxylase
SU48_RS02920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SU48_RS02925	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SU48_RS02955	COG0719	Fe-S assembly protein
SU48_RS02970	COG0719	Fe-S assembly protein
SU48_RS02975	COG0396	ATPase activity
SU48_RS02980	COG0811	peptide transport
SU48_RS02985	COG0848	biopolymer transport protein
SU48_RS03000	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SU48_RS03010	COG0366	Alpha amylase catalytic
SU48_RS03010	COG1874	Beta-galactosidase
SU48_RS03025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SU48_RS03045	COG1305	Transglutaminase-like
SU48_RS03055	COG2308	Evidence 4 Homologs of previously reported genes of
SU48_RS03075	COG0330	HflC and HflK could
SU48_RS03090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SU48_RS03095	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SU48_RS03110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SU48_RS03115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SU48_RS03120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SU48_RS03125	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SU48_RS03130	COG1450	Type ii and iii secretion system protein
SU48_RS03160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SU48_RS03165	COG1461	Dihydroxyacetone kinase
SU48_RS03180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SU48_RS03185	COG3663	DNA glycosylase
SU48_RS03225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SU48_RS03235	COG0789	Transcriptional regulator
SU48_RS03240	COG0494	nUDIX hydrolase
SU48_RS03245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SU48_RS03255	COG0583	DNA-binding transcription factor activity
SU48_RS03260	COG0215	cysteine-tRNA ligase activity
SU48_RS03275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SU48_RS03275	COG0723	plastoquinol--plastocyanin reductase activity
SU48_RS03280	COG0423	glycine-tRNA ligase activity
SU48_RS03285	COG0039	L-malate dehydrogenase activity
SU48_RS03305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SU48_RS03315	COG1595	DNA-templated transcription, initiation
SU48_RS03340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SU48_RS03370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SU48_RS03385	COG1522	sequence-specific DNA binding
SU48_RS03395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SU48_RS03400	COG0512	Glutamine amidotransferase of anthranilate synthase
SU48_RS03405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SU48_RS03415	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SU48_RS03420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SU48_RS03425	COG0131	Imidazoleglycerol-phosphate dehydratase
SU48_RS03445	COG4712	double-strand break repair protein
SU48_RS03455	COG2226	methyltransferase
SU48_RS03460	COG1643	Atp-dependent helicase
SU48_RS03465	COG1011	Hydrolase
SU48_RS03470	COG4221	oxidoreductase activity
SU48_RS03485	COG0446	pyridine nucleotide-disulphide oxidoreductase
SU48_RS03490	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SU48_RS03495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SU48_RS03500	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SU48_RS03505	COG0250	Participates in transcription elongation, termination and antitermination
SU48_RS03510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SU48_RS03515	COG0081	regulation of translation
SU48_RS03520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SU48_RS03525	COG0222	ribosome binding
SU48_RS03540	COG0085	RNA polymerase activity
SU48_RS03545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SU48_RS03555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SU48_RS03570	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SU48_RS03590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SU48_RS03605	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SU48_RS03625	COG2154	pterin-4-alpha-carbinolamine dehydratase
SU48_RS03645	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SU48_RS03655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SU48_RS03660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SU48_RS03670	COG4326	sporulation control protein
SU48_RS03675	COG0402	S-adenosylhomocysteine deaminase activity
SU48_RS03680	COG0254	rRNA binding
SU48_RS03685	COG1363	Peptidase, m42
SU48_RS03700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SU48_RS03710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SU48_RS03715	COG0697	spore germination
SU48_RS03725	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SU48_RS03735	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SU48_RS03740	COG0706	membrane insertase activity
SU48_RS03775	COG2205	protein histidine kinase activity
SU48_RS03805	COG1131	(ABC) transporter
SU48_RS03830	COG3844	kynureninase activity
SU48_RS03835	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SU48_RS03860	COG0187	DNA topoisomerase II activity
SU48_RS03875	COG1388	LysM domain
SU48_RS03875	COG3942	CHAP domain
SU48_RS03880	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SU48_RS03900	COG1652	LysM domain
SU48_RS03900	COG2823	Periplasmic or secreted lipoprotein
SU48_RS03905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SU48_RS03915	COG4585	Histidine kinase
SU48_RS03915	COG2203	Gaf domain
SU48_RS03925	COG2197	response regulator
SU48_RS03940	COG3253	May function as heme-dependent peroxidase
SU48_RS03955	COG0346	lactoylglutathione lyase activity
SU48_RS03960	COG0628	permease
SU48_RS04005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SU48_RS04015	COG1233	COG1233 Phytoene dehydrogenase and related
SU48_RS04020	COG1832	CoA-binding protein
SU48_RS04025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SU48_RS04060	COG3842	ATPase activity
SU48_RS04065	COG4149	molybdate abc transporter
SU48_RS04090	COG0494	nUDIX hydrolase
SU48_RS04095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SU48_RS04100	COG0484	heat shock protein binding
SU48_RS04110	COG1063	alcohol dehydrogenase
SU48_RS04120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SU48_RS04130	COG0714	Associated with various cellular activities
SU48_RS04135	COG5002	protein histidine kinase activity
SU48_RS04135	COG2176	DNA-directed DNA polymerase activity
SU48_RS04140	COG1404	Belongs to the peptidase S8 family
SU48_RS04155	COG1100	Small GTP-binding protein
SU48_RS04165	COG1131	(ABC) transporter
SU48_RS04170	COG2032	superoxide dismutase activity
SU48_RS04180	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SU48_RS04195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SU48_RS04200	COG1959	2 iron, 2 sulfur cluster binding
SU48_RS04215	COG0167	dihydroorotate dehydrogenase activity
SU48_RS04220	COG1454	alcohol dehydrogenase
SU48_RS04240	COG2146	nitrite reductase [NAD(P)H] activity
SU48_RS04240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SU48_RS04245	COG0243	molybdopterin cofactor binding
SU48_RS04260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SU48_RS04270	COG1309	transcriptional regulator
SU48_RS04280	COG0019	diaminopimelate decarboxylase activity
SU48_RS04290	COG0482	sulfurtransferase activity
SU48_RS04325	COG0483	inositol monophosphate 1-phosphatase activity
SU48_RS04340	COG0017	Asparaginyl-tRNA synthetase
SU48_RS04355	COG1073	alpha beta
SU48_RS04375	COG1131	(ABC) transporter
SU48_RS04410	COG1136	(ABC) transporter
SU48_RS04415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SU48_RS04420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SU48_RS04425	COG4221	oxidoreductase activity
SU48_RS04435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SU48_RS04440	COG0037	tRNA processing
SU48_RS04440	COG0590	tRNA wobble adenosine to inosine editing
SU48_RS04450	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SU48_RS04460	COG0497	DNA recombination
SU48_RS04470	COG3655	Transcriptional regulator
SU48_RS04475	COG1028	Short-chain dehydrogenase reductase Sdr
SU48_RS04500	COG1968	undecaprenyl-diphosphatase activity
SU48_RS04520	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SU48_RS04530	COG1404	Belongs to the peptidase S8 family
SU48_RS04540	COG0653	protein targeting
SU48_RS04565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SU48_RS04580	COG3842	ATPase activity
SU48_RS04590	COG0765	amino acid transport
SU48_RS04595	COG1744	ABC transporter substrate-binding protein PnrA-like
SU48_RS04600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SU48_RS04610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SU48_RS04615	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SU48_RS04620	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
SU48_RS04635	COG0366	Alpha amylase catalytic
SU48_RS04640	COG1744	ABC transporter substrate-binding protein PnrA-like
SU48_RS04645	COG1744	ABC transporter substrate-binding protein PnrA-like
SU48_RS04650	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SU48_RS04675	COG2362	D-Aminopeptidase
SU48_RS04680	COG0024	Methionine aminopeptidase
SU48_RS04685	COG3842	ATPase activity
SU48_RS04690	COG1176	ABC-type spermidine putrescine transport system, permease component I
SU48_RS04700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SU48_RS04715	COG2720	vancomycin resistance protein
SU48_RS04730	COG1794	racemase activity, acting on amino acids and derivatives
SU48_RS04750	COG2329	Antibiotic biosynthesis monooxygenase
SU48_RS04755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SU48_RS04765	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SU48_RS04775	COG0028	Belongs to the TPP enzyme family
SU48_RS04785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SU48_RS04800	COG0564	pseudouridine synthase activity
SU48_RS04815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SU48_RS04820	COG1595	DNA-templated transcription, initiation
SU48_RS04830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SU48_RS04840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SU48_RS04845	COG0460	homoserine dehydrogenase
SU48_RS04855	COG0617	tRNA 3'-terminal CCA addition
SU48_RS04865	COG2094	Belongs to the DNA glycosylase MPG family
SU48_RS04875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SU48_RS04880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SU48_RS04890	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SU48_RS04895	COG1674	ftsk spoiiie
SU48_RS04900	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
SU48_RS04930	COG0681	Belongs to the peptidase S26 family
SU48_RS04935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SU48_RS04945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SU48_RS04975	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SU48_RS04980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SU48_RS04985	COG0772	Belongs to the SEDS family
SU48_RS04995	COG2267	carboxylic ester hydrolase activity
SU48_RS05005	COG0174	glutamine synthetase
SU48_RS05010	COG0683	leucine binding
SU48_RS05050	COG0542	response to heat
SU48_RS05055	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SU48_RS05070	COG0542	response to heat
SU48_RS05090	COG0750	zinc metalloprotease
SU48_RS05095	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SU48_RS05100	COG4589	Belongs to the CDS family
SU48_RS05105	COG0233	cytoplasmic translational termination
SU48_RS05110	COG0528	UMP kinase activity
SU48_RS05115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SU48_RS05120	COG0052	Belongs to the universal ribosomal protein uS2 family
SU48_RS05125	COG2364	Membrane
SU48_RS05135	COG0012	GTP binding
SU48_RS05145	COG0492	ferredoxin-NADP+ reductase activity
SU48_RS05155	COG2814	Major facilitator Superfamily
SU48_RS05160	COG0730	response to heat
SU48_RS05170	COG1024	Enoyl-CoA hydratase
SU48_RS05170	COG1250	3-hydroxyacyl-CoA dehydrogenase
SU48_RS05190	COG0183	Belongs to the thiolase family
SU48_RS05200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SU48_RS05230	COG0247	lactate metabolic process
SU48_RS05240	COG0277	FAD linked oxidase domain protein
SU48_RS05250	COG0737	Belongs to the 5'-nucleotidase family
SU48_RS05265	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SU48_RS05280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SU48_RS05295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SU48_RS05300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SU48_RS05305	COG0702	epimerase
SU48_RS05320	COG1024	Enoyl-CoA hydratase
SU48_RS05340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SU48_RS05355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SU48_RS05355	COG0519	Catalyzes the synthesis of GMP from XMP
SU48_RS05360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SU48_RS05365	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SU48_RS05370	COG1079	Belongs to the binding-protein-dependent transport system permease family
SU48_RS05375	COG4603	Belongs to the binding-protein-dependent transport system permease family
SU48_RS05380	COG3845	ABC transporter
SU48_RS05385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SU48_RS05400	COG1653	transport
SU48_RS05405	COG1214	PFAM Peptidase M22, glycoprotease
SU48_RS05420	COG0785	Cytochrome C biogenesis protein
SU48_RS05430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SU48_RS05435	COG0745	RESPONSE REGULATOR receiver
SU48_RS05440	COG0318	PFAM AMP-dependent synthetase and ligase
SU48_RS05450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SU48_RS05475	COG0681	Belongs to the peptidase S26 family
SU48_RS05480	COG1752	Esterase of the alpha-beta hydrolase superfamily
SU48_RS05490	COG0366	Alpha amylase catalytic
SU48_RS05495	COG1316	TRANSCRIPTIONal
SU48_RS05505	COG2226	methyltransferase
SU48_RS05530	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SU48_RS05535	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SU48_RS05540	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SU48_RS05545	COG0649	NAD binding
SU48_RS05555	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SU48_RS05560	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SU48_RS05565	COG1034	ATP synthesis coupled electron transport
SU48_RS05570	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SU48_RS05575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SU48_RS05580	COG0839	Belongs to the complex I subunit 6 family
SU48_RS05585	COG0713	ATP synthesis coupled electron transport
SU48_RS05590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SU48_RS05595	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SU48_RS05600	COG1007	ATP synthesis coupled electron transport
SU48_RS05605	COG3706	GGDEF domain
SU48_RS05615	COG0488	(ABC) transporter
SU48_RS05640	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SU48_RS05645	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SU48_RS05650	COG3424	synthase
SU48_RS05660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SU48_RS05665	COG4636	protein conserved in cyanobacteria
SU48_RS05675	COG4948	Mandelate Racemase Muconate Lactonizing
SU48_RS05690	COG1668	transmembrane transport
SU48_RS05695	COG4555	ABC transporter
SU48_RS05700	COG1121	(ABC) transporter
SU48_RS05735	COG2201	protein-glutamate methylesterase activity
SU48_RS05740	COG3290	protein histidine kinase activity
SU48_RS05760	COG1136	(ABC) transporter
SU48_RS05780	COG0697	spore germination
SU48_RS05795	COG1193	negative regulation of DNA recombination
SU48_RS05815	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SU48_RS05820	COG1846	Transcriptional regulator
SU48_RS05820	COG1940	carbohydrate kinase activity
SU48_RS05830	COG1175	transmembrane transport
SU48_RS05835	COG0395	ABC-type sugar transport system, permease component
SU48_RS05840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SU48_RS05875	COG0791	NLP P60 protein
SU48_RS05875	COG3103	Sh3 type 3 domain protein
SU48_RS05875	COG1388	LysM domain
SU48_RS05885	COG1573	uracil-dna glycosylase
SU48_RS05895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SU48_RS05905	COG0142	geranyltranstransferase activity
SU48_RS05935	COG1703	isobutyryl-CoA mutase activity
SU48_RS05940	COG1755	Isoprenylcysteine carboxyl methyltransferase
SU48_RS06000	COG0113	porphobilinogen synthase activity
SU48_RS06035	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SU48_RS06040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SU48_RS06050	COG1760	l-serine dehydratase
SU48_RS06055	COG1760	l-serine dehydratase
SU48_RS06085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SU48_RS06090	COG0537	adenosine 5'-monophosphoramidase activity
SU48_RS06105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SU48_RS06110	COG0477	Major facilitator Superfamily
SU48_RS06115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SU48_RS06135	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SU48_RS06135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SU48_RS06140	COG1881	PFAM PEBP family protein
SU48_RS06145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SU48_RS06150	COG2045	Belongs to the ComB family
SU48_RS06200	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SU48_RS06215	COG2205	protein histidine kinase activity
SU48_RS06220	COG0745	RESPONSE REGULATOR receiver
SU48_RS06230	COG2267	carboxylic ester hydrolase activity
SU48_RS06235	COG0564	pseudouridine synthase activity
SU48_RS06240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SU48_RS06250	COG2301	Belongs to the HpcH HpaI aldolase family
SU48_RS06255	COG4106	trans-aconitate 2-methyltransferase activity
SU48_RS06275	COG0585	pseudouridine synthase activity
SU48_RS06285	COG0521	Mo-molybdopterin cofactor biosynthetic process
SU48_RS06295	COG1490	D-aminoacyl-tRNA deacylase activity
SU48_RS06300	COG4942	peptidase
SU48_RS06310	COG1628	Protein of unknown function DUF99
SU48_RS06315	COG0737	Belongs to the 5'-nucleotidase family
SU48_RS06335	COG0183	Belongs to the thiolase family
SU48_RS06340	COG0346	lactoylglutathione lyase activity
SU48_RS06365	COG0604	alcohol dehydrogenase
SU48_RS06390	COG0154	amidase activity
SU48_RS06395	COG0077	Prephenate dehydratase
SU48_RS06395	COG1605	Chorismate mutase
SU48_RS06405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SU48_RS06410	COG0009	L-threonylcarbamoyladenylate synthase
SU48_RS06415	COG1459	type II secretion system
SU48_RS06420	COG0784	Response regulator, receiver
SU48_RS06445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SU48_RS06450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SU48_RS06460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SU48_RS06460	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SU48_RS06475	COG1217	gtp-binding protein TYPA
SU48_RS06490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SU48_RS06495	COG0210	DNA helicase
SU48_RS06520	COG3335	DDE superfamily endonuclease
SU48_RS06535	COG0247	lactate metabolic process
SU48_RS06535	COG2181	nitrate reductase activity
SU48_RS06540	COG1307	EDD domain protein, DegV family
SU48_RS06550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SU48_RS06565	COG2224	Isocitrate lyase
SU48_RS06575	COG0295	cytidine deaminase activity
SU48_RS06580	COG1253	flavin adenine dinucleotide binding
SU48_RS06585	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SU48_RS06590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SU48_RS06600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SU48_RS06605	COG4251	negative regulation of phosphorylation
SU48_RS06610	COG5002	protein histidine kinase activity
SU48_RS06620	COG0768	penicillin binding
SU48_RS06630	COG1792	Involved in formation and maintenance of cell shape
SU48_RS06635	COG0424	maF-like protein
SU48_RS06640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SU48_RS06650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SU48_RS06655	COG1331	Highly conserved protein containing a thioredoxin domain
SU48_RS06675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SU48_RS06685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SU48_RS06690	COG1077	Cell shape determining protein MreB Mrl
SU48_RS06705	COG1960	acyl-CoA dehydrogenase activity
SU48_RS06715	COG0129	dihydroxy-acid dehydratase activity
SU48_RS06725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SU48_RS06730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SU48_RS06735	COG0473	3-isopropylmalate dehydrogenase activity
SU48_RS06740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SU48_RS06740	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SU48_RS06775	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SU48_RS06790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SU48_RS06795	COG0205	6-phosphofructokinase activity
SU48_RS06800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SU48_RS06815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SU48_RS06820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SU48_RS06825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SU48_RS06835	COG0436	Aminotransferase
SU48_RS06850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SU48_RS06860	COG2358	TRAP transporter, solute receptor (TAXI family
SU48_RS06880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SU48_RS06880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SU48_RS06890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SU48_RS06895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SU48_RS06900	COG1388	LysM domain
SU48_RS06900	COG0860	N-Acetylmuramoyl-L-alanine amidase
SU48_RS06905	COG2096	Adenosyltransferase
SU48_RS06915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SU48_RS06925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SU48_RS06930	COG1950	PFAM Membrane protein of
SU48_RS06935	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SU48_RS06940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SU48_RS06950	COG1842	Phage shock protein A
SU48_RS06970	COG1960	acyl-CoA dehydrogenase activity
SU48_RS07000	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SU48_RS07020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SU48_RS07020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SU48_RS07035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SU48_RS07045	COG0195	Participates in both transcription termination and antitermination
SU48_RS07050	COG0779	Required for maturation of 30S ribosomal subunits
SU48_RS07055	COG0850	regulation of cytokinetic process
SU48_RS07060	COG1185	polyribonucleotide nucleotidyltransferase activity
SU48_RS07065	COG0514	ATP-dependent DNA helicase (RecQ)
SU48_RS07075	COG0561	phosphatase activity
SU48_RS07080	COG0384	phenazine biosynthesis protein PhzF
SU48_RS07085	COG0017	Asparaginyl-tRNA synthetase
SU48_RS07095	COG0149	triose-phosphate isomerase activity
SU48_RS07105	COG0126	phosphoglycerate kinase activity
SU48_RS07115	COG0438	transferase activity, transferring glycosyl groups
SU48_RS07120	COG1307	EDD domain protein, DegV family
SU48_RS07125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SU48_RS07135	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SU48_RS07140	COG0739	heme binding
SU48_RS07145	COG0745	RESPONSE REGULATOR receiver
SU48_RS07150	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SU48_RS07155	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SU48_RS07160	COG0673	inositol 2-dehydrogenase activity
SU48_RS07170	COG4948	Mandelate Racemase Muconate Lactonizing
SU48_RS07175	COG0791	NLP P60 protein
SU48_RS07185	COG1253	flavin adenine dinucleotide binding
SU48_RS07200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SU48_RS07220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SU48_RS07225	COG1126	abc transporter atp-binding protein
SU48_RS07230	COG1597	lipid kinase activity
SU48_RS07240	COG0124	histidyl-tRNA synthetase
SU48_RS07245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SU48_RS07255	COG0322	excinuclease ABC activity
SU48_RS07340	COG0045	succinate-CoA ligase (ADP-forming) activity
SU48_RS07345	COG0006	proline dipeptidase activity
SU48_RS07350	COG0791	NLP P60 protein
SU48_RS07350	COG1388	LysM domain
SU48_RS07360	COG1164	Oligoendopeptidase f
SU48_RS07375	COG3012	SEC-C Motif Domain Protein
SU48_RS07400	COG1307	EDD domain protein, DegV family
SU48_RS07415	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SU48_RS07420	COG1653	transport
SU48_RS07435	COG0494	nUDIX hydrolase
SU48_RS07440	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SU48_RS07445	COG0784	Response regulator, receiver
SU48_RS07455	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
SU48_RS07470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SU48_RS07480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SU48_RS07485	COG0747	negative chemotaxis
SU48_RS07490	COG0601	transmembrane transport
SU48_RS07495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SU48_RS07500	COG1250	3-hydroxyacyl-CoA dehydrogenase
SU48_RS07500	COG1024	Enoyl-CoA hydratase
SU48_RS07520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SU48_RS07560	COG0123	including yeast histone deacetylase and acetoin utilization protein
SU48_RS07565	COG0483	inositol monophosphate 1-phosphatase activity
SU48_RS07580	COG0339	signal peptide processing
SU48_RS07590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SU48_RS07600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SU48_RS07605	COG1846	Transcriptional regulator
SU48_RS07615	COG0346	lactoylglutathione lyase activity
SU48_RS07630	COG2342	PFAM TM1410 hypothetical-related protein
SU48_RS07650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SU48_RS07655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SU48_RS07665	COG0438	transferase activity, transferring glycosyl groups
SU48_RS07680	COG0714	Associated with various cellular activities
SU48_RS07695	COG2813	Specifically methylates the guanine in position
SU48_RS07700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SU48_RS07725	COG0481	GTPase activity
SU48_RS07730	COG1280	lysine exporter protein (LysE YggA)
SU48_RS07735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SU48_RS07735	COG0072	phenylalanine-tRNA ligase activity
SU48_RS07745	COG2197	response regulator
SU48_RS07760	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SU48_RS07765	COG1028	Short-chain dehydrogenase reductase Sdr
SU48_RS07775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SU48_RS07780	COG0784	Response regulator, receiver
SU48_RS07780	COG3437	response regulator, receiver
SU48_RS07785	COG1309	transcriptional regulator
SU48_RS07790	COG0166	Belongs to the GPI family
SU48_RS07795	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SU48_RS07800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SU48_RS07815	COG0179	Fumarylacetoacetate (FAA) hydrolase
SU48_RS07845	COG1216	Glycosyl transferase, family 2
SU48_RS07875	COG5412	phage tail tape measure protein
SU48_RS07880	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SU48_RS07905	COG0793	Belongs to the peptidase S41A family
SU48_RS07910	COG2884	Cell division ATP-binding protein ftsE
SU48_RS07915	COG2177	Part of the ABC transporter FtsEX involved in
SU48_RS07925	COG0228	four-way junction DNA binding
SU48_RS07930	COG1837	Belongs to the UPF0109 family
SU48_RS07935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SU48_RS07940	COG0336	Belongs to the RNA methyltransferase TrmD family
SU48_RS07950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SU48_RS07955	COG0788	formyltetrahydrofolate deformylase activity
SU48_RS07965	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SU48_RS07980	COG0123	including yeast histone deacetylase and acetoin utilization protein
SU48_RS07990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SU48_RS07995	COG2197	response regulator
SU48_RS08005	COG0813	purine-nucleoside phosphorylase activity
SU48_RS08015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SU48_RS08025	COG1175	transmembrane transport
SU48_RS08030	COG3833	ABC-type maltose transport systems, permease component
SU48_RS08045	COG1960	acyl-CoA dehydrogenase activity
SU48_RS08050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SU48_RS08065	COG2813	Specifically methylates the guanine in position
SU48_RS08065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SU48_RS08070	COG0473	3-isopropylmalate dehydrogenase activity
SU48_RS08075	COG0066	3-isopropylmalate dehydratase activity
SU48_RS08085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SU48_RS08095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SU48_RS08100	COG0159	tryptophan synthase activity
SU48_RS08105	COG0133	tryptophan synthase activity
SU48_RS08110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SU48_RS08120	COG1192	Involved in chromosome partitioning
SU48_RS08130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SU48_RS08155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SU48_RS08200	COG3845	ABC transporter
SU48_RS08205	COG3361	conserved protein (COG2071)
SU48_RS08220	COG0688	phosphatidylethanolamine metabolic process
SU48_RS08235	COG0686	Belongs to the AlaDH PNT family
SU48_RS08240	COG1132	(ABC) transporter
SU48_RS08245	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SU48_RS08250	COG4636	protein conserved in cyanobacteria
SU48_RS08255	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SU48_RS08265	COG0791	NLP P60 protein
SU48_RS08280	COG0471	metal ion transport
SU48_RS08280	COG3273	potassium ion transport
SU48_RS08285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SU48_RS08305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SU48_RS08350	COG1131	(ABC) transporter
SU48_RS08360	COG0826	peptidase U32
SU48_RS08370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SU48_RS08375	COG2151	metal-sulfur cluster biosynthetic enzyme
SU48_RS08380	COG5006	permease, DMT superfamily
SU48_RS08385	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SU48_RS08395	COG2738	Putative neutral zinc metallopeptidase
SU48_RS08400	COG2359	stage V sporulation protein S
SU48_RS08410	COG0067	glutamate synthase
SU48_RS08410	COG0070	glutamate synthase
SU48_RS08410	COG0069	glutamate synthase activity
SU48_RS08430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SU48_RS08435	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SU48_RS08435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SU48_RS08440	COG1040	competence protein
SU48_RS08460	COG3591	Belongs to the peptidase S1B family
SU48_RS08460	COG1864	DNA RNA non-specific endonuclease
SU48_RS08465	COG0667	Aldo Keto reductase
SU48_RS08470	COG0778	Nitroreductase
SU48_RS08485	COG3706	GGDEF domain
SU48_RS08490	COG0105	UTP biosynthetic process
SU48_RS08495	COG4603	Belongs to the binding-protein-dependent transport system permease family
SU48_RS08500	COG1079	Belongs to the binding-protein-dependent transport system permease family
SU48_RS08510	COG1960	acyl-CoA dehydrogenase activity
SU48_RS08515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SU48_RS08540	COG0697	spore germination
SU48_RS08550	COG2009	succinate dehydrogenase
SU48_RS08560	COG1053	succinate dehydrogenase
SU48_RS08565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SU48_RS08580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SU48_RS08585	COG0584	glycerophosphoryl diester phosphodiesterase
SU48_RS08595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SU48_RS08620	COG4269	membrane
SU48_RS08635	COG4106	trans-aconitate 2-methyltransferase activity
SU48_RS08640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SU48_RS08650	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SU48_RS08655	COG0477	Major facilitator Superfamily
SU48_RS08665	COG0189	ligase activity
SU48_RS08680	COG0066	3-isopropylmalate dehydratase activity
SU48_RS08690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SU48_RS08695	COG0318	PFAM AMP-dependent synthetase and ligase
SU48_RS08700	COG4221	oxidoreductase activity
SU48_RS08715	COG0538	isocitrate dehydrogenase activity
SU48_RS08725	COG1175	transmembrane transport
SU48_RS08730	COG0395	ABC-type sugar transport system, permease component
SU48_RS08760	COG1940	carbohydrate kinase activity
SU48_RS08760	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SU48_RS08770	COG1692	metallophosphoesterase
SU48_RS08775	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SU48_RS08790	COG4591	ABC-type transport system involved in lipoprotein release permease component
SU48_RS08805	COG3956	TIGRFAM MazG family protein
SU48_RS08820	COG4221	oxidoreductase activity
SU48_RS08825	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SU48_RS08850	COG2363	Small membrane protein
SU48_RS08855	COG2001	Belongs to the MraZ family
SU48_RS08860	COG0275	rRNA processing
SU48_RS08890	COG1187	pseudouridine synthase activity
SU48_RS08900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SU48_RS08905	COG0154	amidase activity
SU48_RS08910	COG1653	transport
SU48_RS08930	COG0134	indole-3-glycerol-phosphate synthase activity
SU48_RS08935	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SU48_RS08940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SU48_RS08950	COG0495	leucyl-tRNA aminoacylation
SU48_RS08975	COG2197	response regulator
SU48_RS08985	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SU48_RS08990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SU48_RS08995	COG0617	tRNA 3'-terminal CCA addition
SU48_RS09005	COG1994	Peptidase M50
SU48_RS09015	COG0516	GMP reductase activity
SU48_RS09015	COG0517	IMP dehydrogenase activity
SU48_RS09025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SU48_RS09045	COG0556	nucleotide-excision repair
SU48_RS09050	COG0372	Belongs to the citrate synthase family
SU48_RS09060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SU48_RS09070	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SU48_RS09080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SU48_RS09160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SU48_RS09165	COG0601	transmembrane transport
SU48_RS09170	COG0747	negative chemotaxis
SU48_RS09190	COG0151	Belongs to the GarS family
SU48_RS09200	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SU48_RS09215	COG2258	MOSC domain
SU48_RS09220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SU48_RS09235	COG0287	Prephenate dehydrogenase
SU48_RS09250	COG0018	arginyl-trna synthetase
SU48_RS09275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SU48_RS09285	COG3135	benzoate transporter
SU48_RS09300	COG0284	orotidine-5'-phosphate decarboxylase activity
SU48_RS09305	COG1959	2 iron, 2 sulfur cluster binding
SU48_RS09315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SU48_RS09320	COG0529	Catalyzes the synthesis of activated sulfate
SU48_RS09325	COG0175	sulfate reduction
SU48_RS09330	COG2046	Belongs to the sulfate adenylyltransferase family
SU48_RS09345	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SU48_RS09350	COG0534	Mate efflux family protein
SU48_RS09355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SU48_RS09405	COG1012	belongs to the aldehyde dehydrogenase family
SU48_RS09415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SU48_RS09420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SU48_RS09430	COG1381	Involved in DNA repair and RecF pathway recombination
SU48_RS09440	COG1285	pathogenesis
SU48_RS09445	COG1802	Transcriptional regulator
SU48_RS09450	COG0506	proline dehydrogenase activity
SU48_RS09455	COG1012	belongs to the aldehyde dehydrogenase family
SU48_RS09460	COG1404	Belongs to the peptidase S8 family
SU48_RS09470	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SU48_RS09480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SU48_RS09495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SU48_RS09500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SU48_RS09505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SU48_RS09510	COG0640	Transcriptional regulator
SU48_RS09530	COG0180	Tryptophanyl-tRNA synthetase
SU48_RS09540	COG3422	double-strand break repair
SU48_RS09550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SU48_RS09555	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SU48_RS09565	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SU48_RS09570	COG1234	tRNA 3'-trailer cleavage
SU48_RS09580	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SU48_RS09585	COG1796	DNA polymerase
SU48_RS09585	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SU48_RS09595	COG0559	Belongs to the binding-protein-dependent transport system permease family
SU48_RS09620	COG0552	protein localization to endoplasmic reticulum
SU48_RS09630	COG2815	serine threonine protein kinase
SU48_RS09630	COG0515	serine threonine protein kinase
SU48_RS09645	COG0632	four-way junction helicase activity
SU48_RS09655	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SU48_RS09655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SU48_RS09660	COG1660	Displays ATPase and GTPase activities
SU48_RS09665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SU48_RS09675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SU48_RS09680	COG3152	Membrane
SU48_RS09690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SU48_RS09725	COG0489	protein tyrosine kinase activity
SU48_RS09740	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SU48_RS09740	COG1605	Chorismate mutase
SU48_RS09745	COG2346	COG2346, Truncated hemoglobins
SU48_RS09755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SU48_RS09775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SU48_RS09785	COG3383	formate dehydrogenase (NAD+) activity
SU48_RS09790	COG0477	Major facilitator Superfamily
SU48_RS09800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SU48_RS09805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SU48_RS09830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SU48_RS09835	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SU48_RS09835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SU48_RS09850	COG3870	Protein conserved in bacteria
SU48_RS09855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SU48_RS09860	COG2264	protein methyltransferase activity
SU48_RS09870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SU48_RS09880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SU48_RS09885	COG3426	butyrate kinase activity
SU48_RS09900	COG1304	FMN binding
SU48_RS09905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SU48_RS09920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SU48_RS09925	COG1414	Transcriptional regulator
SU48_RS09930	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SU48_RS09935	COG2351	hydroxyisourate hydrolase activity
SU48_RS09960	COG0237	dephospho-CoA kinase activity
SU48_RS09965	COG0504	CTP synthase activity
SU48_RS09990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SU48_RS09995	COG2304	oxidoreductase activity
SU48_RS10010	COG0420	3'-5' exonuclease activity
SU48_RS10015	COG0419	ATPase involved in DNA repair
SU48_RS10025	COG4956	integral membrane protein (PIN domain superfamily)
SU48_RS10030	COG1132	(ABC) transporter
SU48_RS10035	COG1132	(ABC) transporter
SU48_RS10060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SU48_RS10065	COG1254	Belongs to the acylphosphatase family
SU48_RS10095	COG0488	(ABC) transporter
SU48_RS10105	COG1054	Belongs to the UPF0176 family
SU48_RS10115	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SU48_RS10120	COG0540	Belongs to the ATCase OTCase family
SU48_RS10130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SU48_RS10135	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SU48_RS10140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SU48_RS10150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SU48_RS10155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SU48_RS10160	COG1380	Effector of murein hydrolase LrgA
SU48_RS10165	COG1346	cytolysis
SU48_RS10180	COG2137	regulation of response to DNA damage stimulus
SU48_RS10185	COG0268	Binds directly to 16S ribosomal RNA
SU48_RS10200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SU48_RS10205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SU48_RS10220	COG1250	3-hydroxyacyl-CoA dehydrogenase
SU48_RS10270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SU48_RS10285	COG2086	electron transfer activity
SU48_RS10295	COG3437	response regulator, receiver
SU48_RS10325	COG0616	signal peptide processing
SU48_RS10330	COG1164	Oligoendopeptidase f
SU48_RS10335	COG0704	Plays a role in the regulation of phosphate uptake
SU48_RS10340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SU48_RS10345	COG0581	inorganic phosphate transmembrane transporter activity
SU48_RS10350	COG0573	inorganic phosphate transmembrane transporter activity
SU48_RS10355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SU48_RS10360	COG0515	serine threonine protein kinase
SU48_RS10360	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SU48_RS10375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SU48_RS10390	COG3335	DDE superfamily endonuclease
SU48_RS10440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SU48_RS10455	COG0670	Belongs to the BI1 family
SU48_RS10470	COG0717	Belongs to the dCTP deaminase family
SU48_RS10480	COG0303	'Molybdopterin
SU48_RS10485	COG1047	Peptidyl-prolyl cis-trans
SU48_RS10490	COG1047	Peptidyl-prolyl cis-trans
SU48_RS10505	COG0492	ferredoxin-NADP+ reductase activity
SU48_RS10515	COG0539	negative regulation of cytoplasmic translation
SU48_RS10530	COG2226	methyltransferase
SU48_RS10535	COG1562	ergosterol biosynthetic process
SU48_RS10550	COG2267	carboxylic ester hydrolase activity
SU48_RS10555	COG1764	response to oxidative stress
SU48_RS10560	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SU48_RS10565	COG0508	dehydrogenase complex catalyzes the overall conversion of
SU48_RS10575	COG0583	DNA-binding transcription factor activity
SU48_RS10580	COG0563	adenylate kinase activity
SU48_RS10585	COG0556	nucleotide-excision repair
SU48_RS10620	COG2200	EAL domain
SU48_RS10620	COG2771	luxR family
SU48_RS10625	COG2050	protein possibly involved in aromatic compounds catabolism
SU48_RS10670	COG1378	Sugar-specific transcriptional regulator TrmB
SU48_RS10675	COG0831	urea catabolic process
SU48_RS10675	COG0832	Belongs to the urease beta subunit family
SU48_RS10680	COG0804	urea catabolic process
SU48_RS10695	COG0375	protein maturation
SU48_RS10700	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SU48_RS10705	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SU48_RS10710	COG0830	nickel cation binding
SU48_RS10725	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SU48_RS10730	COG0829	nickel cation binding
SU48_RS10735	COG5002	protein histidine kinase activity
SU48_RS10735	COG5001	Diguanylate cyclase
SU48_RS10735	COG3447	MASE1 domain protein
SU48_RS10740	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SU48_RS10745	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SU48_RS10755	COG1660	Displays ATPase and GTPase activities
SU48_RS10760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SU48_RS10770	COG0728	peptidoglycan biosynthetic process
SU48_RS10785	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SU48_RS10810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SU48_RS10810	COG1754	DNA topoisomerase type I activity
SU48_RS10815	COG2949	membrane
SU48_RS10825	COG2323	membrane
SU48_RS10835	COG5001	Diguanylate cyclase
SU48_RS10835	COG3300	MHYT domain
SU48_RS10845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SU48_RS10870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SU48_RS10875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SU48_RS10895	COG1051	belongs to the nudix hydrolase family
SU48_RS10895	COG1056	cytidyltransferase-related domain
SU48_RS10945	COG2873	o-acetylhomoserine
SU48_RS10955	COG0072	phenylalanine-tRNA ligase activity
SU48_RS10955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SU48_RS10970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SU48_RS10975	COG3263	regulation of cellular component size
SU48_RS10980	COG5001	Diguanylate cyclase
SU48_RS10980	COG3300	MHYT domain
SU48_RS10985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SU48_RS10990	COG2199	diguanylate cyclase activity
SU48_RS10990	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SU48_RS11010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SU48_RS11015	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SU48_RS11020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SU48_RS11035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SU48_RS11040	COG1695	Transcriptional regulator
SU48_RS11060	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SU48_RS11085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SU48_RS11090	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SU48_RS11100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SU48_RS11105	COG0251	oxidation-reduction process
SU48_RS11130	COG0736	holo-[acyl-carrier-protein] synthase activity
SU48_RS11135	COG0561	phosphatase activity
SU48_RS11145	COG0321	lipoyl(octanoyl) transferase activity
SU48_RS11150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SU48_RS11155	COG4251	negative regulation of phosphorylation
SU48_RS11165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SU48_RS11170	COG0494	nUDIX hydrolase
SU48_RS11175	COG0196	riboflavin kinase activity
SU48_RS11190	COG0300	oxidoreductase activity
SU48_RS11195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SU48_RS11220	COG2318	DinB family
SU48_RS11230	COG1694	Mazg nucleotide pyrophosphohydrolase
SU48_RS11240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SU48_RS11245	COG0668	transmembrane transport
SU48_RS11250	COG0416	fatty acid biosynthetic process
SU48_RS11265	COG3118	belongs to the thioredoxin family
SU48_RS11275	COG0203	ribosomal protein L17
SU48_RS11280	COG0202	RNA polymerase activity
SU48_RS11285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SU48_RS11290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SU48_RS11295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SU48_RS11300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SU48_RS11305	COG4187	Peptidase family M20/M25/M40
SU48_RS11310	COG0563	adenylate kinase activity
SU48_RS11315	COG0201	protein transport
SU48_RS11320	COG0200	Binds to the 23S rRNA
SU48_RS11325	COG1841	ribosomal large subunit assembly
SU48_RS11330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SU48_RS11335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SU48_RS11340	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SU48_RS11345	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SU48_RS11350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SU48_RS11355	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SU48_RS11360	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SU48_RS11365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SU48_RS11370	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SU48_RS11375	COG0255	Belongs to the universal ribosomal protein uL29 family
SU48_RS11380	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SU48_RS11385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SU48_RS11390	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SU48_RS11395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SU48_RS11400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SU48_RS11405	COG0089	rRNA binding
SU48_RS11410	COG0088	Forms part of the polypeptide exit tunnel
SU48_RS11415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SU48_RS11420	COG0051	transcription antitermination factor activity, RNA binding
SU48_RS11425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SU48_RS11445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SU48_RS11450	COG0049	tRNA binding
SU48_RS11455	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SU48_RS11460	COG0657	acetylesterase activity
SU48_RS11465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SU48_RS11485	COG1435	thymidine kinase activity
SU48_RS11490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SU48_RS11510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SU48_RS11520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SU48_RS11525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SU48_RS11540	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SU48_RS11545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SU48_RS11550	COG0544	peptidyl-prolyl cis-trans isomerase activity
SU48_RS11570	COG1960	acyl-CoA dehydrogenase activity
SU48_RS11580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SU48_RS11585	COG1678	Uncharacterized ACR, COG1678
SU48_RS11600	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SU48_RS11605	COG0436	Aminotransferase
SU48_RS11610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SU48_RS11615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SU48_RS11620	COG2188	Transcriptional regulator
SU48_RS11625	COG3973	AAA domain
SU48_RS11665	COG2385	sporulation resulting in formation of a cellular spore
SU48_RS11675	COG1408	metallophosphoesterase
SU48_RS11700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SU48_RS11700	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SU48_RS11705	COG4566	intracellular signal transduction
SU48_RS11725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SU48_RS11740	COG3437	response regulator, receiver
SU48_RS11740	COG2770	Histidine kinase
SU48_RS11745	COG0302	gtp cyclohydrolase
SU48_RS11750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SU48_RS11765	COG0572	uridine kinase
SU48_RS11780	COG2050	protein possibly involved in aromatic compounds catabolism
SU48_RS11805	COG0142	geranyltranstransferase activity
SU48_RS11810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SU48_RS11815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SU48_RS11830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SU48_RS11845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SU48_RS11855	COG0335	large ribosomal subunit rRNA binding
SU48_RS11880	COG0778	Nitroreductase
SU48_RS11895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SU48_RS11900	COG1121	(ABC) transporter
SU48_RS11910	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SU48_RS11915	COG0523	cobalamin synthesis protein
SU48_RS11935	COG1494	fructose-1,6-bisphosphatase
SU48_RS11955	COG2514	catechol 2,3-dioxygenase activity
SU48_RS11975	COG0824	Thioesterase
SU48_RS11995	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SU48_RS12000	COG0792	nuclease activity
SU48_RS12030	COG1166	arginine decarboxylase activity
SU48_RS12035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SU48_RS12040	COG0138	bifunctional purine biosynthesis protein purh
SU48_RS12045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SU48_RS12050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SU48_RS12055	COG2873	o-acetylhomoserine
SU48_RS12060	COG0735	belongs to the Fur family
SU48_RS12100	COG0281	malic enzyme
SU48_RS12110	COG0432	Pfam Uncharacterised protein family UPF0047
SU48_RS12135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SU48_RS12185	COG0569	domain protein
SU48_RS12190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SU48_RS12195	COG0442	prolyl-tRNA aminoacylation
SU48_RS12200	COG1252	NADH dehydrogenase
SU48_RS12215	COG0494	nUDIX hydrolase
SU48_RS12220	COG0525	valine-tRNA ligase activity
SU48_RS12235	COG1104	cysteine desulfurase activity
SU48_RS12255	COG0789	Transcriptional regulator
SU48_RS12260	COG0765	amino acid transport
SU48_RS12310	COG4294	response to UV
SU48_RS12315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SU48_RS12355	COG1695	Transcriptional regulator
SU48_RS12360	COG0825	malonyl-CoA metabolic process
SU48_RS12365	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SU48_RS12390	COG0559	Belongs to the binding-protein-dependent transport system permease family
SU48_RS12400	COG1607	acyl-coa hydrolase
SU48_RS12410	COG1418	mRNA catabolic process
SU48_RS12425	COG1695	Transcriptional regulator
SU48_RS12445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SU48_RS12460	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SU48_RS12505	COG2801	Transposase and inactivated derivatives
SU48_RS12540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SU48_RS12565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SU48_RS12570	COG0586	Pfam SNARE associated Golgi protein
SU48_RS12575	COG0252	asparaginase activity
SU48_RS12585	COG0181	hydroxymethylbilane synthase activity
SU48_RS12595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SU48_RS12605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SU48_RS12620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SU48_RS12625	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SU48_RS12660	COG1111	helicase
SU48_RS12660	COG1205	dead DEAH box helicase
SU48_RS12680	COG4948	Mandelate Racemase Muconate Lactonizing
SU48_RS12685	COG1363	Peptidase, m42
SU48_RS12690	COG2967	ApaG domain
SU48_RS12705	COG0328	RNA-DNA hybrid ribonuclease activity
SU48_RS12725	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SU48_RS12735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SU48_RS12740	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SU48_RS12745	COG0805	protein transport
SU48_RS12750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SU48_RS12765	COG1764	response to oxidative stress
SU48_RS12775	COG0259	pyridoxamine-phosphate oxidase activity
SU48_RS12780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SU48_RS12785	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SU48_RS12810	COG0107	imidazoleglycerol-phosphate synthase activity
SU48_RS12815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SU48_RS12815	COG0140	phosphoribosyl-ATP diphosphatase activity
SU48_RS12825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SU48_RS12840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SU48_RS12845	COG0509	glycine decarboxylation via glycine cleavage system
SU48_RS12850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SU48_RS12850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SU48_RS12870	COG0358	DNA primase activity
SU48_RS12890	COG0297	glycogen (starch) synthase activity
SU48_RS12920	COG3335	DDE superfamily endonuclease
SU48_RS12930	COG4585	Histidine kinase
SU48_RS12940	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SU48_RS12945	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SU48_RS12955	COG0363	glucosamine-6-phosphate deaminase activity
SU48_RS12960	COG0612	Peptidase, M16
SU48_RS12965	COG0772	Belongs to the SEDS family
SU48_RS12970	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SU48_RS12975	COG2894	cell division
SU48_RS12985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SU48_RS13015	COG0823	Involved in the tonB-independent uptake of proteins
SU48_RS13015	COG4946	Tricorn protease homolog
SU48_RS13015	COG1506	peptidase
SU48_RS13035	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SU48_RS13065	COG0799	negative regulation of ribosome biogenesis
SU48_RS13085	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SU48_RS13145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SU48_RS13170	COG0156	8-amino-7-oxononanoate synthase activity
SU48_RS13180	COG2226	methyltransferase
SU48_RS13185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SU48_RS13190	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SU48_RS13200	COG2095	MarC family integral membrane protein
SU48_RS13220	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SU48_RS13230	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SU48_RS13230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SU48_RS13245	COG2723	6-phospho-beta-galactosidase activity
SU48_RS13250	COG0704	Plays a role in the regulation of phosphate uptake
SU48_RS13255	COG2205	protein histidine kinase activity
SU48_RS13260	COG0745	RESPONSE REGULATOR receiver
SU48_RS13275	COG1120	ATPase activity
SU48_RS13280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SU48_RS13285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SU48_RS13290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SU48_RS13315	COG0315	cyclic pyranopterin monophosphate synthase activity
SU48_RS13325	COG1396	sequence-specific DNA binding
SU48_RS13335	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SU48_RS13340	COG0285	dihydrofolate synthase activity
SU48_RS13345	COG1227	inorganic diphosphatase activity
SU48_RS13350	COG3206	protein involved in exopolysaccharide biosynthesis
SU48_RS13355	COG0343	queuine tRNA-ribosyltransferase activity
SU48_RS13375	COG0314	molybdopterin synthase activity
SU48_RS13380	COG2339	peptidase activity
SU48_RS13385	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SU48_RS13390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SU48_RS13395	COG0601	transmembrane transport
SU48_RS13400	COG4166	transmembrane transport
SU48_RS13405	COG0316	Belongs to the HesB IscA family
SU48_RS13415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SU48_RS13435	COG2197	response regulator
SU48_RS13445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SU48_RS13450	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SU48_RS13455	COG0564	pseudouridine synthase activity
SU48_RS13460	COG1774	PSP1 C-terminal conserved region
SU48_RS13465	COG0251	oxidation-reduction process
SU48_RS13470	COG0631	protein serine/threonine phosphatase activity
SU48_RS13475	COG1803	Methylglyoxal synthase
SU48_RS13485	COG0746	molybdenum cofactor guanylyltransferase activity
SU48_RS13495	COG0783	Belongs to the Dps family
SU48_RS13505	COG0431	NADPH-dependent FMN reductase
SU48_RS13525	COG1132	(ABC) transporter
SU48_RS13530	COG1132	(ABC) transporter
SU48_RS13545	COG1070	Carbohydrate kinase
SU48_RS13570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SU48_RS13585	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SU48_RS13600	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SU48_RS13620	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SU48_RS13625	COG1192	Involved in chromosome partitioning
SU48_RS13635	COG2852	Protein conserved in bacteria
SU48_RS13640	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SU48_RS13655	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SU48_RS13675	COG1160	GTP binding
SU48_RS13715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SU48_RS13725	COG1619	proteins homologs of microcin C7 resistance protein MccF
SU48_RS13730	COG2205	protein histidine kinase activity
SU48_RS13735	COG0745	RESPONSE REGULATOR receiver
SU48_RS13750	COG3706	GGDEF domain
SU48_RS13755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SU48_RS13760	COG0459	protein refolding
SU48_RS13790	COG1496	oxidoreductase activity
SU48_RS13795	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668