locus-tag	class	description
HAV23_RS00010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HAV23_RS00015	COG2094	Belongs to the DNA glycosylase MPG family
HAV23_RS00020	COG0633	Ferredoxin
HAV23_RS00025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HAV23_RS00050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HAV23_RS00060	COG0584	glycerophosphoryl diester phosphodiesterase
HAV23_RS00075	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HAV23_RS00080	COG4269	membrane
HAV23_RS00095	COG3424	synthase
HAV23_RS00100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HAV23_RS00105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HAV23_RS00110	COG1959	2 iron, 2 sulfur cluster binding
HAV23_RS00120	COG0616	signal peptide processing
HAV23_RS00145	COG0719	Fe-S assembly protein
HAV23_RS00170	COG0719	Fe-S assembly protein
HAV23_RS00175	COG0396	ATPase activity
HAV23_RS00190	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HAV23_RS00195	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HAV23_RS00200	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HAV23_RS00205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HAV23_RS00210	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HAV23_RS00215	COG1841	ribosomal large subunit assembly
HAV23_RS00220	COG0200	Binds to the 23S rRNA
HAV23_RS00225	COG0201	protein transport
HAV23_RS00230	COG0563	adenylate kinase activity
HAV23_RS00260	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HAV23_RS00265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HAV23_RS00270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HAV23_RS00275	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HAV23_RS00280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HAV23_RS00285	COG0202	RNA polymerase activity
HAV23_RS00290	COG0203	ribosomal protein L17
HAV23_RS00295	COG0826	peptidase U32
HAV23_RS00315	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HAV23_RS00340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HAV23_RS00355	COG0330	HflC and HflK could
HAV23_RS00365	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HAV23_RS00380	COG1309	transcriptional regulator
HAV23_RS00385	COG0706	membrane insertase activity
HAV23_RS00390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HAV23_RS00400	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HAV23_RS00410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HAV23_RS00415	COG0765	amino acid transport
HAV23_RS00440	COG0113	porphobilinogen synthase activity
HAV23_RS00460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HAV23_RS00465	COG2151	metal-sulfur cluster biosynthetic enzyme
HAV23_RS00470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HAV23_RS00485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HAV23_RS00505	COG3878	Protein conserved in bacteria
HAV23_RS00510	COG0495	leucyl-tRNA aminoacylation
HAV23_RS00535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HAV23_RS00590	COG2873	o-acetylhomoserine
HAV23_RS00595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HAV23_RS00615	COG1902	pentaerythritol trinitrate reductase activity
HAV23_RS00620	COG1136	(ABC) transporter
HAV23_RS00635	COG0189	ligase activity
HAV23_RS00650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HAV23_RS00655	COG1116	anion transmembrane transporter activity
HAV23_RS00665	COG0284	orotidine-5'-phosphate decarboxylase activity
HAV23_RS00675	COG1959	2 iron, 2 sulfur cluster binding
HAV23_RS00680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HAV23_RS00730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HAV23_RS00760	COG2310	stress, protein
HAV23_RS00810	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HAV23_RS00840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HAV23_RS00895	COG0704	Plays a role in the regulation of phosphate uptake
HAV23_RS00900	COG2205	protein histidine kinase activity
HAV23_RS00925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HAV23_RS00930	COG1233	COG1233 Phytoene dehydrogenase and related
HAV23_RS00955	COG2311	Membrane
HAV23_RS00985	COG1476	TRANSCRIPTIONal
HAV23_RS00990	COG0552	protein localization to endoplasmic reticulum
HAV23_RS00995	COG0667	Aldo Keto reductase
HAV23_RS01005	COG0783	Belongs to the Dps family
HAV23_RS01010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HAV23_RS01025	COG0436	Aminotransferase
HAV23_RS01035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HAV23_RS01050	COG0563	adenylate kinase activity
HAV23_RS01060	COG0556	nucleotide-excision repair
HAV23_RS01065	COG0765	amino acid transport
HAV23_RS01070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HAV23_RS01085	COG0571	ribonuclease III activity
HAV23_RS01090	COG0792	nuclease activity
HAV23_RS01095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HAV23_RS01100	COG1121	(ABC) transporter
HAV23_RS01125	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HAV23_RS01130	COG0194	GDP metabolic process
HAV23_RS01135	COG0101	tRNA pseudouridine synthase activity
HAV23_RS01155	COG1324	tolerance protein
HAV23_RS01185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HAV23_RS01215	COG0789	Transcriptional regulator
HAV23_RS01220	COG2814	Major facilitator Superfamily
HAV23_RS01225	COG1160	GTP binding
HAV23_RS01240	COG2313	pseudouridylate synthase activity
HAV23_RS01245	COG1522	sequence-specific DNA binding
HAV23_RS01245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HAV23_RS01265	COG1131	(ABC) transporter
HAV23_RS01270	COG0667	Aldo Keto reductase
HAV23_RS01290	COG2050	protein possibly involved in aromatic compounds catabolism
HAV23_RS01300	COG2314	TM2 domain
HAV23_RS01310	COG0642	Histidine kinase
HAV23_RS01320	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HAV23_RS01350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HAV23_RS01360	COG1058	Belongs to the CinA family
HAV23_RS01360	COG1546	Belongs to the CinA family
HAV23_RS01365	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HAV23_RS01370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HAV23_RS01390	COG2095	MarC family integral membrane protein
HAV23_RS01400	COG1408	metallophosphoesterase
HAV23_RS01405	COG0156	8-amino-7-oxononanoate synthase activity
HAV23_RS01425	COG0802	atpase or kinase
HAV23_RS01430	COG0181	hydroxymethylbilane synthase activity
HAV23_RS01440	COG0252	asparaginase activity
HAV23_RS01445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HAV23_RS01455	COG0494	nUDIX hydrolase
HAV23_RS01460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HAV23_RS01460	COG0072	phenylalanine-tRNA ligase activity
HAV23_RS01480	COG1960	acyl-CoA dehydrogenase activity
HAV23_RS01495	COG0039	L-malate dehydrogenase activity
HAV23_RS01505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HAV23_RS01515	COG2860	membrane
HAV23_RS01525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HAV23_RS01535	COG0193	aminoacyl-tRNA hydrolase activity
HAV23_RS01550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HAV23_RS01555	COG1309	transcriptional regulator
HAV23_RS01570	COG1132	(ABC) transporter
HAV23_RS01580	COG2030	dehydratase
HAV23_RS01580	COG1012	belongs to the aldehyde dehydrogenase family
HAV23_RS01590	COG2151	metal-sulfur cluster biosynthetic enzyme
HAV23_RS01595	COG3396	Phenylacetate-CoA oxygenase
HAV23_RS01605	COG3396	Phenylacetate-CoA oxygenase
HAV23_RS01610	COG1854	S-ribosylhomocysteine lyase activity
HAV23_RS01615	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HAV23_RS01625	COG0083	homoserine kinase activity
HAV23_RS01645	COG0860	N-Acetylmuramoyl-L-alanine amidase
HAV23_RS01660	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HAV23_RS01670	COG0598	Magnesium transport protein CorA
HAV23_RS01680	COG2315	Protein conserved in bacteria
HAV23_RS01710	COG2226	methyltransferase
HAV23_RS01715	COG2050	protein possibly involved in aromatic compounds catabolism
HAV23_RS01725	COG0523	cobalamin synthesis protein
HAV23_RS01735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HAV23_RS01755	COG0745	RESPONSE REGULATOR receiver
HAV23_RS01760	COG0642	Histidine kinase
HAV23_RS01765	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HAV23_RS01775	COG4251	negative regulation of phosphorylation
HAV23_RS01780	COG0784	Response regulator, receiver
HAV23_RS01790	COG1970	mechanosensitive ion channel activity
HAV23_RS01795	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HAV23_RS01810	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HAV23_RS01815	COG1051	belongs to the nudix hydrolase family
HAV23_RS01815	COG1056	cytidyltransferase-related domain
HAV23_RS01840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HAV23_RS01840	COG3153	acetyltransferase
HAV23_RS01845	COG0242	peptide deformylase activity
HAV23_RS01850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HAV23_RS01865	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HAV23_RS01875	COG2318	DinB family
HAV23_RS01890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HAV23_RS01910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HAV23_RS01920	COG1937	Protein conserved in bacteria
HAV23_RS01935	COG2217	Heavy metal translocating P-type atpase
HAV23_RS01980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HAV23_RS01985	COG2433	Pfam Transposase IS66
HAV23_RS01985	COG1418	mRNA catabolic process
HAV23_RS01995	COG1047	Peptidyl-prolyl cis-trans
HAV23_RS02015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HAV23_RS02020	COG1122	ATPase activity
HAV23_RS02025	COG1268	BioY protein
HAV23_RS02030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HAV23_RS02060	COG1250	3-hydroxyacyl-CoA dehydrogenase
HAV23_RS02060	COG1024	Enoyl-CoA hydratase
HAV23_RS02075	COG0183	Belongs to the thiolase family
HAV23_RS02095	COG0823	Involved in the tonB-independent uptake of proteins
HAV23_RS02115	COG1176	ABC-type spermidine putrescine transport system, permease component I
HAV23_RS02140	COG2200	EAL domain
HAV23_RS02150	COG1758	RNA polymerase activity
HAV23_RS02155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HAV23_RS02160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HAV23_RS02175	COG0105	UTP biosynthetic process
HAV23_RS02185	COG1609	Transcriptional regulator
HAV23_RS02190	COG2223	nitrite transmembrane transporter activity
HAV23_RS02195	COG1505	serine-type exopeptidase activity
HAV23_RS02210	COG2819	hydrolase of the alpha beta superfamily
HAV23_RS02225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HAV23_RS02230	COG1024	Enoyl-CoA hydratase
HAV23_RS02235	COG1774	PSP1 C-terminal conserved region
HAV23_RS02240	COG0251	oxidation-reduction process
HAV23_RS02245	COG0631	protein serine/threonine phosphatase activity
HAV23_RS02255	COG0612	Peptidase, M16
HAV23_RS02295	COG0803	Belongs to the bacterial solute-binding protein 9 family
HAV23_RS02300	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HAV23_RS02305	COG1301	dicarboxylic acid transport
HAV23_RS02310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HAV23_RS02350	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HAV23_RS02355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HAV23_RS02360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HAV23_RS02365	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HAV23_RS02390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HAV23_RS02395	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HAV23_RS02415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HAV23_RS02420	COG0217	transcriptional regulatory protein
HAV23_RS02425	COG0596	Alpha beta hydrolase
HAV23_RS02435	COG1073	alpha beta
HAV23_RS02440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HAV23_RS02455	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HAV23_RS02460	COG0745	RESPONSE REGULATOR receiver
HAV23_RS02465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HAV23_RS02485	COG4895	conserved protein (DUF2196)
HAV23_RS02490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HAV23_RS02505	COG2181	nitrate reductase activity
HAV23_RS02505	COG0247	lactate metabolic process
HAV23_RS02520	COG0018	arginyl-trna synthetase
HAV23_RS02535	COG0315	cyclic pyranopterin monophosphate synthase activity
HAV23_RS02545	COG1396	sequence-specific DNA binding
HAV23_RS02550	COG0285	dihydrofolate synthase activity
HAV23_RS02555	COG1227	inorganic diphosphatase activity
HAV23_RS02560	COG3206	protein involved in exopolysaccharide biosynthesis
HAV23_RS02565	COG0343	queuine tRNA-ribosyltransferase activity
HAV23_RS02585	COG0799	negative regulation of ribosome biogenesis
HAV23_RS02600	COG0281	malic enzyme
HAV23_RS02610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HAV23_RS02625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HAV23_RS02630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HAV23_RS02635	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HAV23_RS02665	COG2321	neutral zinc metallopeptidase
HAV23_RS02670	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HAV23_RS02675	COG0432	Pfam Uncharacterised protein family UPF0047
HAV23_RS02705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HAV23_RS02710	COG0163	prenyltransferase activity
HAV23_RS02715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HAV23_RS02720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HAV23_RS02730	COG0314	molybdopterin synthase activity
HAV23_RS02745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HAV23_RS02755	COG0586	Pfam SNARE associated Golgi protein
HAV23_RS02760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HAV23_RS02770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HAV23_RS02780	COG1612	heme a metabolic process
HAV23_RS02780	COG0109	protoheme IX farnesyltransferase activity
HAV23_RS02785	COG0109	protoheme IX farnesyltransferase activity
HAV23_RS02795	COG1845	cytochrome c oxidase, subunit III
HAV23_RS02795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HAV23_RS02810	COG0492	ferredoxin-NADP+ reductase activity
HAV23_RS02825	COG2272	Belongs to the type-B carboxylesterase lipase family
HAV23_RS02830	COG0114	fumarate hydratase activity
HAV23_RS02840	COG1695	Transcriptional regulator
HAV23_RS02850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HAV23_RS02870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HAV23_RS02875	COG0469	pyruvate kinase activity
HAV23_RS02880	COG0148	phosphopyruvate hydratase activity
HAV23_RS02885	COG0592	DNA-directed DNA polymerase activity
HAV23_RS02890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HAV23_RS02900	COG1051	belongs to the nudix hydrolase family
HAV23_RS02905	COG1378	Sugar-specific transcriptional regulator TrmB
HAV23_RS02910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HAV23_RS02915	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HAV23_RS02925	COG2720	vancomycin resistance protein
HAV23_RS02935	COG0702	epimerase
HAV23_RS02940	COG1475	DNA binding
HAV23_RS02945	COG1192	Involved in chromosome partitioning
HAV23_RS02950	COG0357	Ribosomal RNA small subunit methyltransferase G
HAV23_RS02960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HAV23_RS02980	COG0557	exoribonuclease II activity
HAV23_RS03010	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HAV23_RS03015	COG2720	vancomycin resistance protein
HAV23_RS03020	COG2226	methyltransferase
HAV23_RS03025	COG0445	tRNA wobble uridine modification
HAV23_RS03035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HAV23_RS03040	COG0022	dehydrogenase e1 component
HAV23_RS03050	COG0508	dehydrogenase complex catalyzes the overall conversion of
HAV23_RS03065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HAV23_RS03070	COG0302	gtp cyclohydrolase
HAV23_RS03080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HAV23_RS03115	COG4948	Mandelate Racemase Muconate Lactonizing
HAV23_RS03140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HAV23_RS03160	COG2318	DinB family
HAV23_RS03175	COG3135	benzoate transporter
HAV23_RS03185	COG2815	serine threonine protein kinase
HAV23_RS03185	COG0515	serine threonine protein kinase
HAV23_RS03200	COG3842	ATPase activity
HAV23_RS03205	COG1307	EDD domain protein, DegV family
HAV23_RS03210	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HAV23_RS03215	COG1205	dead DEAH box helicase
HAV23_RS03215	COG1111	helicase
HAV23_RS03260	COG0857	belongs to the CobB CobQ family
HAV23_RS03260	COG0280	phosphate acetyltransferase
HAV23_RS03265	COG1309	transcriptional regulator
HAV23_RS03270	COG1511	domain protein
HAV23_RS03270	COG1511	domain protein
HAV23_RS03275	COG0303	'Molybdopterin
HAV23_RS03280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HAV23_RS03285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HAV23_RS03290	COG0494	nUDIX hydrolase
HAV23_RS03295	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HAV23_RS03320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HAV23_RS03325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HAV23_RS03330	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HAV23_RS03335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HAV23_RS03375	COG1132	(ABC) transporter
HAV23_RS03380	COG1132	(ABC) transporter
HAV23_RS03390	COG0360	Binds together with S18 to 16S ribosomal RNA
HAV23_RS03395	COG0629	single-stranded DNA binding
HAV23_RS03400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HAV23_RS03405	COG0359	binds to the 23S rRNA
HAV23_RS03430	COG0534	Mate efflux family protein
HAV23_RS03435	COG2409	Drug exporters of the RND superfamily
HAV23_RS03445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HAV23_RS03450	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HAV23_RS03475	COG0439	Biotin carboxylase
HAV23_RS03480	COG0511	ligase activity, forming carbon-carbon bonds
HAV23_RS03485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HAV23_RS03490	COG0758	DNA mediated transformation
HAV23_RS03500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HAV23_RS03505	COG0135	phosphoribosylanthranilate isomerase activity
HAV23_RS03520	COG0484	heat shock protein binding
HAV23_RS03525	COG4628	conserved protein (DUF2132)
HAV23_RS03530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HAV23_RS03540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HAV23_RS03550	COG2326	polyphosphate kinase activity
HAV23_RS03585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HAV23_RS03605	COG0084	hydrolase, TatD family'
HAV23_RS03620	COG0525	valine-tRNA ligase activity
HAV23_RS03625	COG0494	nUDIX hydrolase
HAV23_RS03645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HAV23_RS03645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HAV23_RS03655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HAV23_RS03655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HAV23_RS03660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HAV23_RS03675	COG0572	uridine kinase
HAV23_RS03695	COG1132	(ABC) transporter
HAV23_RS03705	COG4946	Tricorn protease homolog
HAV23_RS03705	COG1506	peptidase
HAV23_RS03705	COG0823	Involved in the tonB-independent uptake of proteins
HAV23_RS03715	COG2856	Zn peptidase
HAV23_RS03720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HAV23_RS03750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HAV23_RS03755	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HAV23_RS03775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HAV23_RS03795	COG0069	glutamate synthase activity
HAV23_RS03795	COG0067	glutamate synthase
HAV23_RS03795	COG0070	glutamate synthase
HAV23_RS03805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HAV23_RS03810	COG1570	exodeoxyribonuclease VII activity
HAV23_RS03815	COG2949	membrane
HAV23_RS03825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HAV23_RS03850	COG2738	Putative neutral zinc metallopeptidase
HAV23_RS03860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HAV23_RS03870	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HAV23_RS03875	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HAV23_RS03880	COG1522	sequence-specific DNA binding
HAV23_RS03905	COG1131	(ABC) transporter
HAV23_RS03925	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HAV23_RS03935	COG0668	transmembrane transport
HAV23_RS03955	COG1104	cysteine desulfurase activity
HAV23_RS03965	COG2897	thiosulfate sulfurtransferase activity
HAV23_RS03980	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HAV23_RS03985	COG2852	Protein conserved in bacteria
HAV23_RS03990	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HAV23_RS03995	COG0047	phosphoribosylformylglycinamidine synthase activity
HAV23_RS04000	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HAV23_RS04010	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HAV23_RS04020	COG2967	ApaG domain
HAV23_RS04030	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HAV23_RS04035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HAV23_RS04055	COG2309	aminopeptidase activity
HAV23_RS04060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HAV23_RS04065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HAV23_RS04075	COG0561	phosphatase activity
HAV23_RS04100	COG2890	protein-(glutamine-N5) methyltransferase activity
HAV23_RS04110	COG0736	holo-[acyl-carrier-protein] synthase activity
HAV23_RS04135	COG0628	permease
HAV23_RS04170	COG0477	Major facilitator Superfamily
HAV23_RS04180	COG2807	transmembrane transport
HAV23_RS04185	COG0494	nUDIX hydrolase
HAV23_RS04190	COG4143	(ABC) transporter
HAV23_RS04210	COG2188	Transcriptional regulator
HAV23_RS04230	COG0513	Belongs to the DEAD box helicase family
HAV23_RS04235	COG1234	tRNA 3'-trailer cleavage
HAV23_RS04275	COG0406	alpha-ribazole phosphatase activity
HAV23_RS04280	COG1607	acyl-coa hydrolase
HAV23_RS04300	COG0411	ABC transporter
HAV23_RS04320	COG0567	Dehydrogenase, E1 component
HAV23_RS04345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HAV23_RS04355	COG0546	phosphoglycolate phosphatase activity
HAV23_RS04365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HAV23_RS04375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HAV23_RS04380	COG1428	Deoxynucleoside kinase
HAV23_RS04385	COG1428	Deoxynucleoside kinase
HAV23_RS04390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HAV23_RS04400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HAV23_RS04410	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HAV23_RS04415	COG0049	tRNA binding
HAV23_RS04420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HAV23_RS04435	COG0051	transcription antitermination factor activity, RNA binding
HAV23_RS04440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HAV23_RS04445	COG0088	Forms part of the polypeptide exit tunnel
HAV23_RS04450	COG0089	rRNA binding
HAV23_RS04455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HAV23_RS04460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HAV23_RS04465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HAV23_RS04470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HAV23_RS04475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HAV23_RS04480	COG0255	Belongs to the universal ribosomal protein uL29 family
HAV23_RS04485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HAV23_RS04490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HAV23_RS04495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HAV23_RS04500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HAV23_RS04510	COG0039	L-malate dehydrogenase activity
HAV23_RS04520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HAV23_RS04545	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HAV23_RS04565	COG0318	PFAM AMP-dependent synthetase and ligase
HAV23_RS04585	COG0285	dihydrofolate synthase activity
HAV23_RS04595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HAV23_RS04600	COG0723	plastoquinol--plastocyanin reductase activity
HAV23_RS04605	COG2010	Cytochrome c
HAV23_RS04615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HAV23_RS04620	COG1138	Cytochrome C-type biogenesis protein
HAV23_RS04625	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HAV23_RS04630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HAV23_RS04635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HAV23_RS04640	COG2815	serine threonine protein kinase
HAV23_RS04640	COG0515	serine threonine protein kinase
HAV23_RS04655	COG0708	Exodeoxyribonuclease III
HAV23_RS04670	COG1678	Uncharacterized ACR, COG1678
HAV23_RS04695	COG1181	Belongs to the D-alanine--D-alanine ligase family
HAV23_RS04700	COG0747	negative chemotaxis
HAV23_RS04705	COG0601	transmembrane transport
HAV23_RS04715	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HAV23_RS04735	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HAV23_RS04745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HAV23_RS04770	COG1760	l-serine dehydratase
HAV23_RS04795	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HAV23_RS04815	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HAV23_RS04835	COG1461	Dihydroxyacetone kinase
HAV23_RS04850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HAV23_RS04855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HAV23_RS04860	COG2814	Major facilitator Superfamily
HAV23_RS04870	COG0243	molybdopterin cofactor binding
HAV23_RS04880	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HAV23_RS04885	COG1674	ftsk spoiiie
HAV23_RS04890	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
HAV23_RS04920	COG0784	Response regulator, receiver
HAV23_RS04935	COG4221	oxidoreductase activity
HAV23_RS04940	COG0492	ferredoxin-NADP+ reductase activity
HAV23_RS04950	COG1011	Hydrolase
HAV23_RS04990	COG4106	trans-aconitate 2-methyltransferase activity
HAV23_RS04995	COG4712	double-strand break repair protein
HAV23_RS05000	COG0131	Imidazoleglycerol-phosphate dehydratase
HAV23_RS05010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HAV23_RS05015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HAV23_RS05035	COG2226	methyltransferase
HAV23_RS05040	COG2197	response regulator
HAV23_RS05065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HAV23_RS05080	COG0316	Belongs to the HesB IscA family
HAV23_RS05085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HAV23_RS05090	COG2339	peptidase activity
HAV23_RS05105	COG0438	transferase activity, transferring glycosyl groups
HAV23_RS05120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HAV23_RS05135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HAV23_RS05140	COG0174	glutamine synthetase
HAV23_RS05155	COG1968	undecaprenyl-diphosphatase activity
HAV23_RS05165	COG0811	peptide transport
HAV23_RS05185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HAV23_RS05190	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HAV23_RS05205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HAV23_RS05210	COG2340	Cysteine-rich secretory protein family
HAV23_RS05220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HAV23_RS05220	COG1796	DNA polymerase
HAV23_RS05230	COG4636	protein conserved in cyanobacteria
HAV23_RS05235	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HAV23_RS05255	COG1136	(ABC) transporter
HAV23_RS05255	COG0577	efflux transmembrane transporter activity
HAV23_RS05260	COG0488	(ABC) transporter
HAV23_RS05270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HAV23_RS05285	COG0037	tRNA processing
HAV23_RS05300	COG3012	SEC-C Motif Domain Protein
HAV23_RS05310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HAV23_RS05320	COG4591	ABC-type transport system involved in lipoprotein release permease component
HAV23_RS05330	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HAV23_RS05345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HAV23_RS05350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HAV23_RS05355	COG0259	pyridoxamine-phosphate oxidase activity
HAV23_RS05365	COG1760	l-serine dehydratase
HAV23_RS05380	COG0728	peptidoglycan biosynthetic process
HAV23_RS05390	COG1307	EDD domain protein, DegV family
HAV23_RS05395	COG0167	dihydroorotate dehydrogenase activity
HAV23_RS05400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HAV23_RS05410	COG2226	methyltransferase
HAV23_RS05415	COG0737	Belongs to the 5'-nucleotidase family
HAV23_RS05415	COG4085	toxin activity
HAV23_RS05415	COG1525	nuclease
HAV23_RS05425	COG0587	DNA-directed DNA polymerase activity
HAV23_RS05430	COG1715	Restriction endonuclease
HAV23_RS05445	COG1116	anion transmembrane transporter activity
HAV23_RS05450	COG0697	spore germination
HAV23_RS05600	COG0584	glycerophosphoryl diester phosphodiesterase
HAV23_RS05605	COG1028	Short-chain dehydrogenase reductase Sdr
HAV23_RS05610	COG0730	response to heat
HAV23_RS05630	COG4968	Prepilin-type N-terminal cleavage methylation domain
HAV23_RS05635	COG0305	Participates in initiation and elongation during chromosome replication
HAV23_RS05645	COG1960	acyl-CoA dehydrogenase activity
HAV23_RS05665	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HAV23_RS05670	COG1832	CoA-binding protein
HAV23_RS05680	COG0180	Tryptophanyl-tRNA synthetase
HAV23_RS05695	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HAV23_RS05700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HAV23_RS05700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HAV23_RS05705	COG2182	Extracellular solute-binding protein
HAV23_RS05715	COG3833	ABC-type maltose transport systems, permease component
HAV23_RS05735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HAV23_RS05740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HAV23_RS05775	COG2385	sporulation resulting in formation of a cellular spore
HAV23_RS05790	COG0653	protein targeting
HAV23_RS05830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HAV23_RS05835	COG0788	formyltetrahydrofolate deformylase activity
HAV23_RS05845	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HAV23_RS05850	COG1715	Restriction endonuclease
HAV23_RS05885	COG0297	glycogen (starch) synthase activity
HAV23_RS05900	COG2255	four-way junction helicase activity
HAV23_RS05925	COG0358	DNA primase activity
HAV23_RS05930	COG0406	alpha-ribazole phosphatase activity
HAV23_RS05935	COG0037	tRNA processing
HAV23_RS05935	COG0590	tRNA wobble adenosine to inosine editing
HAV23_RS05945	COG3706	GGDEF domain
HAV23_RS05950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HAV23_RS05955	COG0459	protein refolding
HAV23_RS05965	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HAV23_RS05975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HAV23_RS05980	COG4187	Peptidase family M20/M25/M40
HAV23_RS05985	COG3665	Urea carboxylase-associated protein
HAV23_RS05995	COG0583	DNA-binding transcription factor activity
HAV23_RS06015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HAV23_RS06025	COG0714	Associated with various cellular activities
HAV23_RS06030	COG0436	Aminotransferase
HAV23_RS06040	COG0431	NADPH-dependent FMN reductase
HAV23_RS06050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HAV23_RS06055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HAV23_RS06060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HAV23_RS06065	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HAV23_RS06095	COG0205	6-phosphofructokinase activity
HAV23_RS06100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HAV23_RS06125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HAV23_RS06135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HAV23_RS06140	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HAV23_RS06155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HAV23_RS06160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HAV23_RS06210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HAV23_RS06235	COG2337	Toxic component of a toxin-antitoxin (TA) module
HAV23_RS06255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HAV23_RS06285	COG0137	argininosuccinate synthase activity
HAV23_RS06305	COG0165	Argininosuccinate lyase
HAV23_RS06330	COG1444	tRNA N-acetyltransferase activity
HAV23_RS06335	COG0505	Belongs to the CarA family
HAV23_RS06370	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HAV23_RS06385	COG0347	Belongs to the P(II) protein family
HAV23_RS06400	COG1269	ATP hydrolysis coupled proton transport
HAV23_RS06410	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HAV23_RS06415	COG1527	subunit (C
HAV23_RS06420	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
HAV23_RS06425	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HAV23_RS06430	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HAV23_RS06435	COG1394	ATPase activity, coupled to movement of substances
HAV23_RS06450	COG2342	PFAM TM1410 hypothetical-related protein
HAV23_RS06475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HAV23_RS06480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HAV23_RS06490	COG0438	transferase activity, transferring glycosyl groups
HAV23_RS06505	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HAV23_RS06510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HAV23_RS06515	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HAV23_RS06520	COG0784	Response regulator, receiver
HAV23_RS06520	COG3437	response regulator, receiver
HAV23_RS06565	COG1028	Short-chain dehydrogenase reductase Sdr
HAV23_RS06570	COG0784	Response regulator, receiver
HAV23_RS06575	COG0107	imidazoleglycerol-phosphate synthase activity
HAV23_RS06580	COG0140	phosphoribosyl-ATP diphosphatase activity
HAV23_RS06580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HAV23_RS06620	COG1438	arginine binding
HAV23_RS06635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HAV23_RS06650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HAV23_RS06660	COG2200	EAL domain
HAV23_RS06660	COG2203	Gaf domain
HAV23_RS06660	COG2199	diguanylate cyclase activity
HAV23_RS06665	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HAV23_RS06670	COG2894	cell division
HAV23_RS06680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HAV23_RS06685	COG0335	large ribosomal subunit rRNA binding
HAV23_RS06695	COG0372	Belongs to the citrate synthase family
HAV23_RS06730	COG0321	lipoyl(octanoyl) transferase activity
HAV23_RS06735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HAV23_RS06785	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HAV23_RS06790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HAV23_RS06795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HAV23_RS06800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HAV23_RS06810	COG2819	hydrolase of the alpha beta superfamily
HAV23_RS06820	COG0745	RESPONSE REGULATOR receiver
HAV23_RS06825	COG3191	aminopeptidase activity
HAV23_RS06835	COG0494	nUDIX hydrolase
HAV23_RS06860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HAV23_RS06865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HAV23_RS06870	COG2267	carboxylic ester hydrolase activity
HAV23_RS06875	COG0534	Mate efflux family protein
HAV23_RS06880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HAV23_RS06885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HAV23_RS06910	COG0673	inositol 2-dehydrogenase activity
HAV23_RS06920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HAV23_RS06925	COG5343	regulation of RNA biosynthetic process
HAV23_RS06935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HAV23_RS06940	COG0805	protein transport
HAV23_RS06945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HAV23_RS06950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HAV23_RS06975	COG1012	belongs to the aldehyde dehydrogenase family
HAV23_RS06980	COG0506	proline dehydrogenase activity
HAV23_RS06985	COG1802	Transcriptional regulator
HAV23_RS07005	COG1381	Involved in DNA repair and RecF pathway recombination
HAV23_RS07030	COG0402	S-adenosylhomocysteine deaminase activity
HAV23_RS07035	COG0254	rRNA binding
HAV23_RS07040	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HAV23_RS07045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HAV23_RS07050	COG2224	Isocitrate lyase
HAV23_RS07060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HAV23_RS07070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HAV23_RS07080	COG0123	including yeast histone deacetylase and acetoin utilization protein
HAV23_RS07120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HAV23_RS07125	COG2318	DinB family
HAV23_RS07140	COG1331	Highly conserved protein containing a thioredoxin domain
HAV23_RS07145	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HAV23_RS07155	COG2050	protein possibly involved in aromatic compounds catabolism
HAV23_RS07160	COG4942	peptidase
HAV23_RS07175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HAV23_RS07190	COG1100	Small GTP-binding protein
HAV23_RS07210	COG2176	DNA-directed DNA polymerase activity
HAV23_RS07225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HAV23_RS07230	COG2205	protein histidine kinase activity
HAV23_RS07230	COG2202	Pas domain
HAV23_RS07240	COG1562	ergosterol biosynthetic process
HAV23_RS07255	COG0735	belongs to the Fur family
HAV23_RS07265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HAV23_RS07270	COG0138	bifunctional purine biosynthesis protein purh
HAV23_RS07285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HAV23_RS07290	COG2873	o-acetylhomoserine
HAV23_RS07310	COG0494	nUDIX hydrolase
HAV23_RS07330	COG2111	Na H antiporter
HAV23_RS07335	COG1006	Multisubunit Na H antiporter MnhC subunit
HAV23_RS07350	COG2212	antiporter activity
HAV23_RS07355	COG1320	monovalent cation:proton antiporter activity
HAV23_RS07365	COG1652	LysM domain
HAV23_RS07365	COG2823	Periplasmic or secreted lipoprotein
HAV23_RS07375	COG1490	D-aminoacyl-tRNA deacylase activity
HAV23_RS07380	COG2197	response regulator
HAV23_RS07385	COG2205	protein histidine kinase activity
HAV23_RS07390	COG0670	Belongs to the BI1 family
HAV23_RS07405	COG1187	pseudouridine synthase activity
HAV23_RS07435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HAV23_RS07450	COG0187	DNA topoisomerase II activity
HAV23_RS07455	COG1278	Cold shock
HAV23_RS07475	COG1388	LysM domain
HAV23_RS07475	COG3942	CHAP domain
HAV23_RS07480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HAV23_RS07485	COG0085	RNA polymerase activity
HAV23_RS07490	COG2813	Specifically methylates the guanine in position
HAV23_RS07540	COG1960	acyl-CoA dehydrogenase activity
HAV23_RS07555	COG0306	phosphate transporter
HAV23_RS07560	COG1668	transmembrane transport
HAV23_RS07565	COG1131	(ABC) transporter
HAV23_RS07575	COG1254	Belongs to the acylphosphatase family
HAV23_RS07590	COG0142	geranyltranstransferase activity
HAV23_RS07600	COG0789	Transcriptional regulator
HAV23_RS07605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HAV23_RS07610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HAV23_RS07625	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HAV23_RS07635	COG0133	tryptophan synthase activity
HAV23_RS07640	COG0159	tryptophan synthase activity
HAV23_RS07650	COG3118	belongs to the thioredoxin family
HAV23_RS07660	COG1363	Peptidase, m42
HAV23_RS07680	COG1252	NADH dehydrogenase
HAV23_RS07685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HAV23_RS07690	COG1053	succinate dehydrogenase
HAV23_RS07700	COG2009	succinate dehydrogenase
HAV23_RS07725	COG0601	transmembrane transport
HAV23_RS07735	COG0564	pseudouridine synthase activity
HAV23_RS07745	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HAV23_RS07760	COG0646	methionine synthase
HAV23_RS07760	COG1410	methionine synthase
HAV23_RS07785	COG2086	electron transfer activity
HAV23_RS07800	COG0563	adenylate kinase activity
HAV23_RS07810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HAV23_RS07815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HAV23_RS07835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HAV23_RS07840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HAV23_RS07845	COG3706	GGDEF domain
HAV23_RS07850	COG1994	Peptidase M50
HAV23_RS07860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HAV23_RS07865	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HAV23_RS07870	COG0747	negative chemotaxis
HAV23_RS07875	COG2197	response regulator
HAV23_RS07890	COG0517	IMP dehydrogenase activity
HAV23_RS07890	COG1125	glycine betaine transport
HAV23_RS07895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HAV23_RS07920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HAV23_RS07925	COG0489	protein tyrosine kinase activity
HAV23_RS07940	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HAV23_RS07940	COG1605	Chorismate mutase
HAV23_RS07945	COG2346	COG2346, Truncated hemoglobins
HAV23_RS07955	COG2076	Multidrug Resistance protein
HAV23_RS07960	COG2076	Multidrug Resistance protein
HAV23_RS07965	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HAV23_RS07970	COG0494	nUDIX hydrolase
HAV23_RS07975	COG0196	riboflavin kinase activity
HAV23_RS07985	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HAV23_RS07990	COG1131	(ABC) transporter
HAV23_RS08005	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HAV23_RS08025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HAV23_RS08030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HAV23_RS08045	COG2318	DinB family
HAV23_RS08050	COG0494	nUDIX hydrolase
HAV23_RS08055	COG0277	FAD linked oxidase domain protein
HAV23_RS08060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HAV23_RS08065	COG0765	amino acid transport
HAV23_RS08070	COG1396	sequence-specific DNA binding
HAV23_RS08075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HAV23_RS08080	COG1304	FMN binding
HAV23_RS08120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HAV23_RS08150	COG0542	response to heat
HAV23_RS08185	COG1073	alpha beta
HAV23_RS08195	COG0017	Asparaginyl-tRNA synthetase
HAV23_RS08240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HAV23_RS08265	COG1250	3-hydroxyacyl-CoA dehydrogenase
HAV23_RS08275	COG3340	Belongs to the peptidase S51 family
HAV23_RS08300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HAV23_RS08330	COG1215	transferase activity, transferring glycosyl groups
HAV23_RS08340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HAV23_RS08350	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HAV23_RS08350	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HAV23_RS08360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HAV23_RS08375	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HAV23_RS08380	COG3706	GGDEF domain
HAV23_RS08395	COG0180	Tryptophanyl-tRNA synthetase
HAV23_RS08410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HAV23_RS08415	COG0406	alpha-ribazole phosphatase activity
HAV23_RS08445	COG0488	(ABC) transporter
HAV23_RS08455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HAV23_RS08460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HAV23_RS08475	COG0540	Belongs to the ATCase OTCase family
HAV23_RS08480	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HAV23_RS08500	COG0071	Belongs to the small heat shock protein (HSP20) family
HAV23_RS08515	COG0542	response to heat
HAV23_RS08520	COG4956	integral membrane protein (PIN domain superfamily)
HAV23_RS08535	COG3426	butyrate kinase activity
HAV23_RS08545	COG0287	Prephenate dehydrogenase
HAV23_RS08550	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HAV23_RS08555	COG3206	protein involved in exopolysaccharide biosynthesis
HAV23_RS08565	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HAV23_RS08590	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HAV23_RS08595	COG0129	dihydroxy-acid dehydratase activity
HAV23_RS08600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HAV23_RS08660	COG0481	GTPase activity
HAV23_RS08670	COG0077	Prephenate dehydratase
HAV23_RS08670	COG1605	Chorismate mutase
HAV23_RS08675	COG0490	domain, Protein
HAV23_RS08680	COG0475	glutathione-regulated potassium exporter activity
HAV23_RS08685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HAV23_RS08690	COG1024	Enoyl-CoA hydratase
HAV23_RS08700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HAV23_RS08705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HAV23_RS08715	COG1414	Transcriptional regulator
HAV23_RS08745	COG2351	hydroxyisourate hydrolase activity
HAV23_RS08750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HAV23_RS08760	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HAV23_RS08780	COG2816	NAD+ diphosphatase activity
HAV23_RS08800	COG5412	phage tail tape measure protein
HAV23_RS08805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HAV23_RS08810	COG0784	Response regulator, receiver
HAV23_RS08810	COG5002	protein histidine kinase activity
HAV23_RS08810	COG2205	protein histidine kinase activity
HAV23_RS08855	COG3956	TIGRFAM MazG family protein
HAV23_RS08870	COG0861	Integral membrane protein TerC family
HAV23_RS08875	COG0628	permease
HAV23_RS08880	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HAV23_RS08880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HAV23_RS08890	COG0617	tRNA 3'-terminal CCA addition
HAV23_RS08925	COG0693	protein deglycase activity
HAV23_RS08955	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HAV23_RS08965	COG0590	tRNA wobble adenosine to inosine editing
HAV23_RS08965	COG0037	tRNA processing
HAV23_RS08975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HAV23_RS09000	COG0825	malonyl-CoA metabolic process
HAV23_RS09005	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HAV23_RS09025	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HAV23_RS09025	COG1918	ferrous iron import across plasma membrane
HAV23_RS09110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HAV23_RS09120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HAV23_RS09130	COG2301	Belongs to the HpcH HpaI aldolase family
HAV23_RS09145	COG2815	serine threonine protein kinase
HAV23_RS09145	COG0515	serine threonine protein kinase
HAV23_RS09165	COG0045	succinate-CoA ligase (ADP-forming) activity
HAV23_RS09205	COG1960	acyl-CoA dehydrogenase activity
HAV23_RS09235	COG2304	oxidoreductase activity
HAV23_RS09265	COG0442	prolyl-tRNA aminoacylation
HAV23_RS09285	COG0017	Asparaginyl-tRNA synthetase
HAV23_RS09295	COG0778	Nitroreductase
HAV23_RS09310	COG0632	four-way junction helicase activity
HAV23_RS09315	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HAV23_RS09320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HAV23_RS09335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HAV23_RS09345	COG1692	metallophosphoesterase
HAV23_RS09355	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HAV23_RS09375	COG0514	ATP-dependent DNA helicase (RecQ)
HAV23_RS09380	COG0747	negative chemotaxis
HAV23_RS09385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HAV23_RS09390	COG0521	Mo-molybdopterin cofactor biosynthetic process
HAV23_RS09400	COG0228	four-way junction DNA binding
HAV23_RS09415	COG2354	Protein conserved in bacteria
HAV23_RS09430	COG0785	Cytochrome C biogenesis protein
HAV23_RS09440	COG3842	ATPase activity
HAV23_RS09450	COG1177	transmembrane transport
HAV23_RS09455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HAV23_RS09465	COG0477	Major facilitator Superfamily
HAV23_RS09470	COG0793	Belongs to the peptidase S41A family
HAV23_RS09475	COG0268	Binds directly to 16S ribosomal RNA
HAV23_RS09480	COG2137	regulation of response to DNA damage stimulus
HAV23_RS09490	COG0024	Methionine aminopeptidase
HAV23_RS09505	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HAV23_RS09515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HAV23_RS09525	COG1960	acyl-CoA dehydrogenase activity
HAV23_RS09545	COG2814	Major facilitator Superfamily
HAV23_RS09550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HAV23_RS09560	COG0791	NLP P60 protein
HAV23_RS09570	COG0477	Major facilitator Superfamily
HAV23_RS09585	COG0384	phenazine biosynthesis protein PhzF
HAV23_RS09595	COG1472	Belongs to the glycosyl hydrolase 3 family
HAV23_RS09600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HAV23_RS09610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HAV23_RS09620	COG0149	triose-phosphate isomerase activity
HAV23_RS09635	COG0126	phosphoglycerate kinase activity
HAV23_RS09655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HAV23_RS09665	COG0124	histidyl-tRNA synthetase
HAV23_RS09670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HAV23_RS09680	COG2267	carboxylic ester hydrolase activity
HAV23_RS09690	COG0322	excinuclease ABC activity
HAV23_RS09695	COG0671	phosphoesterase, PA-phosphatase related
HAV23_RS09700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HAV23_RS09705	COG2011	ABC-type metal ion transport system permease component
HAV23_RS09715	COG1464	Belongs to the NlpA lipoprotein family
HAV23_RS09725	COG0791	NLP P60 protein
HAV23_RS09735	COG1597	lipid kinase activity
HAV23_RS09750	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HAV23_RS09755	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HAV23_RS09760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HAV23_RS09790	COG1754	DNA topoisomerase type I activity
HAV23_RS09790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HAV23_RS09795	COG0366	Alpha amylase catalytic
HAV23_RS09810	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HAV23_RS09840	COG0012	GTP binding
HAV23_RS09855	COG1040	competence protein
HAV23_RS09885	COG0142	geranyltranstransferase activity
HAV23_RS09910	COG2045	Belongs to the ComB family
HAV23_RS09915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HAV23_RS09955	COG0471	metal ion transport
HAV23_RS09955	COG3273	potassium ion transport
HAV23_RS09985	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HAV23_RS09990	COG0745	RESPONSE REGULATOR receiver
HAV23_RS10000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HAV23_RS10015	COG3870	Protein conserved in bacteria
HAV23_RS10020	COG0484	heat shock protein binding
HAV23_RS10030	COG0134	indole-3-glycerol-phosphate synthase activity
HAV23_RS10035	COG0681	Belongs to the peptidase S26 family
HAV23_RS10040	COG0183	Belongs to the thiolase family
HAV23_RS10055	COG0151	Belongs to the GarS family
HAV23_RS10070	COG1660	Displays ATPase and GTPase activities
HAV23_RS10075	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HAV23_RS10090	COG1653	transport
HAV23_RS10100	COG2217	Heavy metal translocating P-type atpase
HAV23_RS10120	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HAV23_RS10125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HAV23_RS10140	COG1346	cytolysis
HAV23_RS10150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HAV23_RS10155	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HAV23_RS10175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HAV23_RS10185	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HAV23_RS10215	COG4221	oxidoreductase activity
HAV23_RS10220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HAV23_RS10235	COG1196	nuclear chromosome segregation
HAV23_RS10250	COG1842	Phage shock protein A
HAV23_RS10260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HAV23_RS10295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HAV23_RS10320	COG1024	Enoyl-CoA hydratase
HAV23_RS10320	COG1250	3-hydroxyacyl-CoA dehydrogenase
HAV23_RS10325	COG1316	TRANSCRIPTIONal
HAV23_RS10330	COG0604	alcohol dehydrogenase
HAV23_RS10345	COG1007	ATP synthesis coupled electron transport
HAV23_RS10350	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HAV23_RS10360	COG0713	ATP synthesis coupled electron transport
HAV23_RS10365	COG0839	Belongs to the complex I subunit 6 family
HAV23_RS10370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HAV23_RS10375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HAV23_RS10385	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HAV23_RS10390	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HAV23_RS10400	COG0649	NAD binding
HAV23_RS10405	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HAV23_RS10410	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HAV23_RS10415	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HAV23_RS10420	COG0750	zinc metalloprotease
HAV23_RS10425	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HAV23_RS10430	COG0575	Belongs to the CDS family
HAV23_RS10435	COG0233	cytoplasmic translational termination
HAV23_RS10440	COG0528	UMP kinase activity
HAV23_RS10445	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HAV23_RS10450	COG0052	Belongs to the universal ribosomal protein uS2 family
HAV23_RS10465	COG0028	Belongs to the TPP enzyme family
HAV23_RS10470	COG0440	acetolactate synthase activity
HAV23_RS10480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HAV23_RS10490	COG2264	protein methyltransferase activity
HAV23_RS10495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HAV23_RS10510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HAV23_RS10515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HAV23_RS10525	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HAV23_RS10525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HAV23_RS10565	COG2267	carboxylic ester hydrolase activity
HAV23_RS10570	COG1764	response to oxidative stress
HAV23_RS10580	COG0538	isocitrate dehydrogenase activity
HAV23_RS10590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HAV23_RS10600	COG1960	acyl-CoA dehydrogenase activity
HAV23_RS10610	COG2032	superoxide dismutase activity
HAV23_RS10625	COG2177	Part of the ABC transporter FtsEX involved in
HAV23_RS10630	COG2884	Cell division ATP-binding protein ftsE
HAV23_RS10635	COG0793	Belongs to the peptidase S41A family
HAV23_RS10645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HAV23_RS10650	COG1307	EDD domain protein, DegV family
HAV23_RS10655	COG0438	transferase activity, transferring glycosyl groups
HAV23_RS10660	COG2203	Gaf domain
HAV23_RS10660	COG4585	Histidine kinase
HAV23_RS10670	COG2197	response regulator
HAV23_RS10680	COG1597	lipid kinase activity
HAV23_RS10685	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HAV23_RS10690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HAV23_RS10695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HAV23_RS10725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HAV23_RS10730	COG0601	transmembrane transport
HAV23_RS10735	COG0747	negative chemotaxis
HAV23_RS10740	COG3973	AAA domain
HAV23_RS10745	COG0504	CTP synthase activity
HAV23_RS10750	COG0688	phosphatidylethanolamine metabolic process
HAV23_RS10765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HAV23_RS10775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HAV23_RS10790	COG1131	(ABC) transporter
HAV23_RS10810	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HAV23_RS10815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HAV23_RS10825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HAV23_RS10850	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HAV23_RS10865	COG0612	Peptidase, M16
HAV23_RS10870	COG1864	DNA RNA non-specific endonuclease
HAV23_RS10870	COG3591	Belongs to the peptidase S1B family
HAV23_RS10890	COG0726	polysaccharide deacetylase
HAV23_RS10895	COG0745	RESPONSE REGULATOR receiver
HAV23_RS10915	COG0179	Fumarylacetoacetate (FAA) hydrolase
HAV23_RS10920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HAV23_RS10940	COG0066	3-isopropylmalate dehydratase activity
HAV23_RS10955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HAV23_RS10960	COG2720	vancomycin resistance protein
HAV23_RS10965	COG1028	Short-chain dehydrogenase reductase Sdr
HAV23_RS10970	COG0537	adenosine 5'-monophosphoramidase activity
HAV23_RS10975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HAV23_RS10990	COG0154	amidase activity
HAV23_RS10995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HAV23_RS11000	COG1164	Oligoendopeptidase f
HAV23_RS11005	COG0789	Transcriptional regulator
HAV23_RS11030	COG0860	N-Acetylmuramoyl-L-alanine amidase
HAV23_RS11045	COG0488	(ABC) transporter
HAV23_RS11050	COG2329	Antibiotic biosynthesis monooxygenase
HAV23_RS11060	COG2096	Adenosyltransferase
HAV23_RS11095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HAV23_RS11100	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HAV23_RS11105	COG1126	abc transporter atp-binding protein
HAV23_RS11110	COG2358	TRAP transporter, solute receptor (TAXI family
HAV23_RS11140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HAV23_RS11160	COG0339	signal peptide processing
HAV23_RS11170	COG2359	stage V sporulation protein S
HAV23_RS11175	COG1063	alcohol dehydrogenase
HAV23_RS11190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HAV23_RS11200	COG0569	domain protein
HAV23_RS11210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HAV23_RS11215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HAV23_RS11215	COG0116	Belongs to the methyltransferase superfamily
HAV23_RS11220	COG0215	cysteine-tRNA ligase activity
HAV23_RS11230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HAV23_RS11230	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HAV23_RS11235	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HAV23_RS11235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HAV23_RS11240	COG0473	3-isopropylmalate dehydrogenase activity
HAV23_RS11265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HAV23_RS11270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HAV23_RS11275	COG0445	tRNA wobble uridine modification
HAV23_RS11285	COG2808	Putative FMN-binding domain
HAV23_RS11290	COG0564	pseudouridine synthase activity
HAV23_RS11295	COG1192	Involved in chromosome partitioning
HAV23_RS11305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HAV23_RS11315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HAV23_RS11320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HAV23_RS11330	COG0318	PFAM AMP-dependent synthetase and ligase
HAV23_RS11340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HAV23_RS11350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HAV23_RS11360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HAV23_RS11385	COG0483	inositol monophosphate 1-phosphatase activity
HAV23_RS11395	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HAV23_RS11410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HAV23_RS11410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HAV23_RS11420	COG1914	H( )-stimulated, divalent metal cation uptake system
HAV23_RS11435	COG0747	negative chemotaxis
HAV23_RS11500	COG2319	Wd-40 repeat
HAV23_RS11510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HAV23_RS11510	COG0574	Belongs to the PEP-utilizing enzyme family
HAV23_RS11515	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HAV23_RS11525	COG0247	lactate metabolic process
HAV23_RS11530	COG0277	FAD linked oxidase domain protein
HAV23_RS11555	COG0737	Belongs to the 5'-nucleotidase family
HAV23_RS11585	COG0166	Belongs to the GPI family
HAV23_RS11600	COG1755	Isoprenylcysteine carboxyl methyltransferase
HAV23_RS11610	COG1703	isobutyryl-CoA mutase activity
HAV23_RS11630	COG1573	uracil-dna glycosylase
HAV23_RS11645	COG0850	regulation of cytokinetic process
HAV23_RS11650	COG1185	polyribonucleotide nucleotidyltransferase activity
HAV23_RS11660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HAV23_RS11670	COG0019	diaminopimelate decarboxylase activity
HAV23_RS11675	COG0482	sulfurtransferase activity
HAV23_RS11700	COG2514	catechol 2,3-dioxygenase activity
HAV23_RS11710	COG0512	Glutamine amidotransferase of anthranilate synthase
HAV23_RS11715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HAV23_RS11725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HAV23_RS11735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HAV23_RS11770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HAV23_RS11795	COG0066	3-isopropylmalate dehydratase activity
HAV23_RS11800	COG0473	3-isopropylmalate dehydrogenase activity
HAV23_RS11810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HAV23_RS11830	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HAV23_RS11865	COG0779	Required for maturation of 30S ribosomal subunits
HAV23_RS11870	COG0195	Participates in both transcription termination and antitermination
HAV23_RS11880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HAV23_RS11885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HAV23_RS11925	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HAV23_RS11930	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HAV23_RS11930	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HAV23_RS11940	COG0509	glycine decarboxylation via glycine cleavage system
HAV23_RS11945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HAV23_RS11960	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HAV23_RS11985	COG4294	response to UV
HAV23_RS12000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HAV23_RS12000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HAV23_RS12005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HAV23_RS12010	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HAV23_RS12020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HAV23_RS12025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HAV23_RS12060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HAV23_RS12065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HAV23_RS12080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HAV23_RS12110	COG2362	D-Aminopeptidase
HAV23_RS12125	COG1695	Transcriptional regulator
HAV23_RS12135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HAV23_RS12140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HAV23_RS12150	COG0515	serine threonine protein kinase
HAV23_RS12170	COG0154	amidase activity
HAV23_RS12175	COG1764	response to oxidative stress
HAV23_RS12190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HAV23_RS12195	COG0009	L-threonylcarbamoyladenylate synthase
HAV23_RS12205	COG2363	Small membrane protein
HAV23_RS12210	COG2001	Belongs to the MraZ family
HAV23_RS12215	COG0275	rRNA processing
HAV23_RS12240	COG4948	Mandelate Racemase Muconate Lactonizing
HAV23_RS12255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HAV23_RS12255	COG0519	Catalyzes the synthesis of GMP from XMP
HAV23_RS12260	COG2364	Membrane
HAV23_RS12275	COG0517	IMP dehydrogenase activity
HAV23_RS12275	COG0516	GMP reductase activity
HAV23_RS12285	COG1272	protein, Hemolysin III
HAV23_RS12305	COG1609	Transcriptional regulator
HAV23_RS12315	COG1999	signal sequence binding
HAV23_RS12335	COG0667	Aldo Keto reductase
HAV23_RS12345	COG0237	dephospho-CoA kinase activity
HAV23_RS12360	COG0686	Belongs to the AlaDH PNT family
HAV23_RS12375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HAV23_RS12400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HAV23_RS12405	COG1307	EDD domain protein, DegV family
HAV23_RS12420	COG1620	l-lactate permease
HAV23_RS12425	COG0247	lactate metabolic process
HAV23_RS12430	COG1139	Iron-sulfur cluster binding protein
HAV23_RS12435	COG1556	Lactate utilization protein
HAV23_RS12440	COG3265	gluconokinase activity
HAV23_RS12455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HAV23_RS12465	COG1073	alpha beta
HAV23_RS12470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HAV23_RS12495	COG0420	3'-5' exonuclease activity
HAV23_RS12500	COG0419	ATPase involved in DNA repair
HAV23_RS12525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HAV23_RS12530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HAV23_RS12540	COG2390	Transcriptional regulator
HAV23_RS12565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HAV23_RS12575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HAV23_RS12580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HAV23_RS12585	COG1028	Short-chain dehydrogenase reductase Sdr
HAV23_RS12595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HAV23_RS12600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HAV23_RS12605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HAV23_RS12610	COG0544	peptidyl-prolyl cis-trans isomerase activity
HAV23_RS12615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HAV23_RS12640	COG1695	Transcriptional regulator
HAV23_RS12645	COG0747	negative chemotaxis
HAV23_RS12710	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HAV23_RS12720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HAV23_RS12725	COG0778	Nitroreductase
HAV23_RS12745	COG0740	serine-type endopeptidase activity
HAV23_RS12750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HAV23_RS12755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HAV23_RS12765	COG1193	negative regulation of DNA recombination
HAV23_RS12785	COG0702	epimerase
HAV23_RS12795	COG0492	ferredoxin-NADP+ reductase activity
HAV23_RS12805	COG0539	negative regulation of cytoplasmic translation
HAV23_RS12810	COG1435	thymidine kinase activity
HAV23_RS12820	COG1307	EDD domain protein, DegV family
HAV23_RS12845	COG0585	pseudouridine synthase activity
HAV23_RS12855	COG1305	Transglutaminase-like
HAV23_RS12865	COG0668	transmembrane transport
HAV23_RS12880	COG0753	catalase activity
HAV23_RS12885	COG1280	lysine exporter protein (LysE YggA)
HAV23_RS12910	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HAV23_RS12915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HAV23_RS12930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HAV23_RS12935	COG1837	Belongs to the UPF0109 family
HAV23_RS12940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HAV23_RS12945	COG0336	Belongs to the RNA methyltransferase TrmD family
HAV23_RS12955	COG1494	fructose-1,6-bisphosphatase
HAV23_RS13000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HAV23_RS13020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HAV23_RS13025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HAV23_RS13060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HAV23_RS13075	COG4762	Protein conserved in bacteria
HAV23_RS13095	COG1192	Involved in chromosome partitioning
HAV23_RS13105	COG2308	Evidence 4 Homologs of previously reported genes of
HAV23_RS13110	COG0222	ribosome binding
HAV23_RS13115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HAV23_RS13120	COG0081	regulation of translation
HAV23_RS13125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HAV23_RS13130	COG0250	Participates in transcription elongation, termination and antitermination
HAV23_RS13135	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HAV23_RS13140	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HAV23_RS13145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HAV23_RS13170	COG1132	(ABC) transporter
HAV23_RS13175	COG1132	(ABC) transporter
HAV23_RS13180	COG0704	Plays a role in the regulation of phosphate uptake
HAV23_RS13185	COG1164	Oligoendopeptidase f
HAV23_RS13210	COG0423	glycine-tRNA ligase activity
HAV23_RS13230	COG1185	polyribonucleotide nucleotidyltransferase activity
HAV23_RS13235	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HAV23_RS13240	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HAV23_RS13245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HAV23_RS13255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HAV23_RS13260	COG1744	ABC transporter substrate-binding protein PnrA-like
HAV23_RS13265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HAV23_RS13270	COG2373	Large extracellular alpha-helical protein
HAV23_RS13295	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HAV23_RS13300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HAV23_RS13305	COG1404	Belongs to the peptidase S8 family
HAV23_RS13310	COG4932	domain protein
HAV23_RS13315	COG1136	(ABC) transporter
HAV23_RS13320	COG0577	efflux transmembrane transporter activity
HAV23_RS13330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HAV23_RS13335	COG0281	malic enzyme
HAV23_RS13360	COG0477	Major facilitator Superfamily
HAV23_RS13365	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HAV23_RS13385	COG0318	PFAM AMP-dependent synthetase and ligase
HAV23_RS13410	COG0693	protein deglycase activity
HAV23_RS13410	COG0753	catalase activity
HAV23_RS13430	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HAV23_RS13435	COG2366	antibiotic biosynthetic process
HAV23_RS13445	COG0789	Transcriptional regulator
HAV23_RS13450	COG2130	NADP-dependent
HAV23_RS13455	COG1960	acyl-CoA dehydrogenase activity
HAV23_RS13470	COG0477	Major facilitator Superfamily
HAV23_RS13475	COG0747	negative chemotaxis
HAV23_RS13485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HAV23_RS13485	COG1017	nitric oxide dioxygenase activity
HAV23_RS13505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HAV23_RS13515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HAV23_RS13520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HAV23_RS13525	COG2080	2 iron, 2 sulfur cluster binding
HAV23_RS13535	COG2080	2 iron, 2 sulfur cluster binding
HAV23_RS13540	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HAV23_RS13545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HAV23_RS13585	COG2368	4-hydroxyphenylacetate
HAV23_RS13590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HAV23_RS13620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HAV23_RS13630	COG0655	NAD(P)H dehydrogenase (quinone) activity
HAV23_RS13635	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HAV23_RS13640	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HAV23_RS13645	COG2188	Transcriptional regulator
HAV23_RS13650	COG0747	negative chemotaxis
HAV23_RS13655	COG0601	transmembrane transport
HAV23_RS13660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HAV23_RS13675	COG4251	negative regulation of phosphorylation
HAV23_RS13680	COG0784	Response regulator, receiver
HAV23_RS13690	COG2032	superoxide dismutase activity
HAV23_RS13695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HAV23_RS13700	COG1028	Short-chain dehydrogenase reductase Sdr
HAV23_RS13720	COG1960	acyl-CoA dehydrogenase activity
HAV23_RS13755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HAV23_RS13775	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HAV23_RS13780	COG2252	PERMEase
HAV23_RS13790	COG3706	GGDEF domain
HAV23_RS13795	COG0402	S-adenosylhomocysteine deaminase activity
HAV23_RS13805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HAV23_RS13815	COG2233	PERMEase
HAV23_RS13820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HAV23_RS13825	COG0352	thiamine-phosphate diphosphorylase activity
HAV23_RS13835	COG2022	thiamine diphosphate biosynthetic process
HAV23_RS13840	COG0351	phosphomethylpyrimidine kinase
HAV23_RS13850	COG0725	ABC transporter, periplasmic molybdate-binding protein
HAV23_RS13860	COG1628	Protein of unknown function DUF99
HAV23_RS13875	COG3118	belongs to the thioredoxin family
HAV23_RS13890	COG0704	Plays a role in the regulation of phosphate uptake
HAV23_RS13895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HAV23_RS13905	COG0573	inorganic phosphate transmembrane transporter activity
HAV23_RS13910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HAV23_RS13915	COG1937	Protein conserved in bacteria
HAV23_RS13920	COG4974	Belongs to the 'phage' integrase family
HAV23_RS13925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HAV23_RS13940	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HAV23_RS13955	COG1228	amidohydrolase
HAV23_RS13960	COG2986	histidine ammonia-lyase
HAV23_RS13965	COG0753	catalase activity
HAV23_RS13980	COG1250	3-hydroxyacyl-CoA dehydrogenase
HAV23_RS13985	COG1309	transcriptional regulator
HAV23_RS14000	COG0784	Response regulator, receiver
HAV23_RS14005	COG1174	glycine betaine transport
HAV23_RS14010	COG0517	IMP dehydrogenase activity
HAV23_RS14010	COG1125	glycine betaine transport
HAV23_RS14015	COG1174	glycine betaine transport
HAV23_RS14020	COG1732	Glycine betaine
HAV23_RS14045	COG3608	succinylglutamate desuccinylase aspartoacylase
HAV23_RS14045	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HAV23_RS14080	COG3971	2-oxopent-4-enoate hydratase activity
HAV23_RS14085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HAV23_RS14090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HAV23_RS14115	COG3179	chitinase
HAV23_RS14235	COG4373	Mu-like prophage FluMu protein gp28
HAV23_RS14350	COG2217	Heavy metal translocating P-type atpase
HAV23_RS14360	COG0640	Transcriptional regulator
HAV23_RS14370	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HAV23_RS14375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HAV23_RS14390	COG0776	regulation of translation
HAV23_RS14400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HAV23_RS14410	COG0477	Major facilitator Superfamily
HAV23_RS14445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HAV23_RS14450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HAV23_RS14455	COG0183	Belongs to the thiolase family
HAV23_RS14465	COG4251	negative regulation of phosphorylation
HAV23_RS14470	COG0784	Response regulator, receiver
HAV23_RS14475	COG1482	cell wall glycoprotein biosynthetic process
HAV23_RS14480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HAV23_RS14500	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HAV23_RS14520	COG0438	transferase activity, transferring glycosyl groups
HAV23_RS14530	COG1215	transferase activity, transferring glycosyl groups
HAV23_RS14545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HAV23_RS14565	COG1012	belongs to the aldehyde dehydrogenase family
HAV23_RS14585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HAV23_RS14595	COG2843	Capsule synthesis protein
HAV23_RS14620	COG0737	Belongs to the 5'-nucleotidase family
HAV23_RS14630	COG2046	Belongs to the sulfate adenylyltransferase family
HAV23_RS14635	COG0175	sulfate reduction
HAV23_RS14640	COG0529	Catalyzes the synthesis of activated sulfate
HAV23_RS14645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HAV23_RS14660	COG2197	response regulator
HAV23_RS14675	COG1131	(ABC) transporter
HAV23_RS14690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HAV23_RS14695	COG1012	belongs to the aldehyde dehydrogenase family
HAV23_RS14705	COG1192	Involved in chromosome partitioning
HAV23_RS14735	COG1028	Short-chain dehydrogenase reductase Sdr
HAV23_RS14750	COG0598	Magnesium transport protein CorA
HAV23_RS14780	COG2198	Histidine kinase
HAV23_RS14780	COG0784	Response regulator, receiver
HAV23_RS14780	COG0643	Histidine kinase
HAV23_RS14820	COG1132	(ABC) transporter
HAV23_RS14825	COG1012	belongs to the aldehyde dehydrogenase family
HAV23_RS14845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HAV23_RS14850	COG1012	belongs to the aldehyde dehydrogenase family
HAV23_RS14880	COG3483	tryptophan 2,3-dioxygenase activity
HAV23_RS14885	COG3844	kynureninase activity
HAV23_RS14890	COG1960	acyl-CoA dehydrogenase activity
HAV23_RS14940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HAV23_RS14960	COG0411	ABC transporter
HAV23_RS14980	COG0832	Belongs to the urease beta subunit family
HAV23_RS14980	COG0831	urea catabolic process
HAV23_RS14985	COG0804	urea catabolic process
HAV23_RS14995	COG0375	protein maturation
HAV23_RS15000	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HAV23_RS15005	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HAV23_RS15010	COG0830	nickel cation binding
HAV23_RS15015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HAV23_RS15020	COG0829	nickel cation binding
HAV23_RS15025	COG4770	biotin carboxylase activity
HAV23_RS15030	COG0318	PFAM AMP-dependent synthetase and ligase
HAV23_RS15035	COG1309	transcriptional regulator
HAV23_RS15050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HAV23_RS15050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HAV23_RS15065	COG1858	cytochrome C peroxidase
HAV23_RS15085	COG5001	Diguanylate cyclase
HAV23_RS15085	COG3300	MHYT domain
HAV23_RS15115	COG2801	Transposase and inactivated derivatives
HAV23_RS15135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HAV23_RS15160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HAV23_RS15165	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HAV23_RS15170	COG1797	cobyrinic acid a,c-diamide synthase activity
HAV23_RS15175	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HAV23_RS15180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HAV23_RS15205	COG1192	Involved in chromosome partitioning
HAV23_RS15220	COG1401	restriction endodeoxyribonuclease activity
HAV23_RS15265	COG1115	amino acid carrier protein
HAV23_RS15275	COG0861	Integral membrane protein TerC family
HAV23_RS15280	COG1253	flavin adenine dinucleotide binding
HAV23_RS15285	COG1253	flavin adenine dinucleotide binding
HAV23_RS15295	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HAV23_RS15305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HAV23_RS15310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HAV23_RS15315	COG1120	ATPase activity
HAV23_RS15360	COG0584	glycerophosphoryl diester phosphodiesterase
HAV23_RS15370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HAV23_RS15375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HAV23_RS15455	COG3706	GGDEF domain
HAV23_RS15465	COG0745	RESPONSE REGULATOR receiver
HAV23_RS15470	COG0642	Histidine kinase
HAV23_RS15480	COG2205	protein histidine kinase activity
HAV23_RS15505	COG2205	protein histidine kinase activity
HAV23_RS15510	COG2197	response regulator
HAV23_RS15520	COG4948	Mandelate Racemase Muconate Lactonizing
HAV23_RS15525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HAV23_RS15535	COG1349	DNA-binding transcription factor activity
HAV23_RS15540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HAV23_RS15540	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HAV23_RS15570	COG1404	Belongs to the peptidase S8 family
HAV23_RS15575	COG4932	domain protein
HAV23_RS15650	COG2376	Dihydroxyacetone kinase
HAV23_RS15655	COG1461	Dihydroxyacetone kinase
HAV23_RS15660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HAV23_RS15660	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HAV23_RS15660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HAV23_RS15675	COG1136	(ABC) transporter
HAV23_RS15685	COG1785	Belongs to the alkaline phosphatase family
HAV23_RS15705	COG0747	negative chemotaxis
HAV23_RS15735	COG3706	GGDEF domain
HAV23_RS15750	COG1192	Involved in chromosome partitioning
HAV23_RS15760	COG4251	negative regulation of phosphorylation
HAV23_RS15765	COG0784	Response regulator, receiver
HAV23_RS15765	COG2198	Histidine kinase
HAV23_RS15765	COG5002	protein histidine kinase activity
HAV23_RS15775	COG2172	sigma factor antagonist activity
HAV23_RS15780	COG1366	Belongs to the anti-sigma-factor antagonist family
HAV23_RS15785	COG1366	Belongs to the anti-sigma-factor antagonist family
HAV23_RS15870	COG2192	nodulation
HAV23_RS15875	COG0312	modulator of DNA gyrase
HAV23_RS15900	COG0574	Belongs to the PEP-utilizing enzyme family
HAV23_RS15900	COG3848	Pyruvate phosphate dikinase
HAV23_RS15910	COG0084	hydrolase, TatD family'
HAV23_RS15950	COG0860	N-Acetylmuramoyl-L-alanine amidase
HAV23_RS15980	COG4974	Belongs to the 'phage' integrase family