locus-tag	class	description
HLB42_RS00010	COG0758	DNA mediated transformation
HLB42_RS00025	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HLB42_RS00030	COG0592	DNA-directed DNA polymerase activity
HLB42_RS00035	COG0148	phosphopyruvate hydratase activity
HLB42_RS00040	COG0469	pyruvate kinase activity
HLB42_RS00045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLB42_RS00065	COG1758	RNA polymerase activity
HLB42_RS00070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HLB42_RS00075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HLB42_RS00085	COG0443	Heat shock 70 kDa protein
HLB42_RS00090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HLB42_RS00095	COG4628	conserved protein (DUF2132)
HLB42_RS00100	COG0484	heat shock protein binding
HLB42_RS00105	COG5002	protein histidine kinase activity
HLB42_RS00130	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HLB42_RS00190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HLB42_RS00250	COG0633	Ferredoxin
HLB42_RS00255	COG0442	prolyl-tRNA aminoacylation
HLB42_RS00260	COG3706	GGDEF domain
HLB42_RS00280	COG0318	PFAM AMP-dependent synthetase and ligase
HLB42_RS00290	COG2819	hydrolase of the alpha beta superfamily
HLB42_RS00300	COG2746	aminoglycoside 3-N-acetyltransferase activity
HLB42_RS00310	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HLB42_RS00315	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLB42_RS00325	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HLB42_RS00340	COG1024	Enoyl-CoA hydratase
HLB42_RS00345	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HLB42_RS00375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HLB42_RS00380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HLB42_RS00385	COG1854	S-ribosylhomocysteine lyase activity
HLB42_RS00405	COG0343	queuine tRNA-ribosyltransferase activity
HLB42_RS00410	COG3206	protein involved in exopolysaccharide biosynthesis
HLB42_RS00415	COG1227	inorganic diphosphatase activity
HLB42_RS00420	COG0285	dihydrofolate synthase activity
HLB42_RS00435	COG4106	trans-aconitate 2-methyltransferase activity
HLB42_RS00475	COG0668	transmembrane transport
HLB42_RS00485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLB42_RS00485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLB42_RS00560	COG1940	carbohydrate kinase activity
HLB42_RS00570	COG0459	protein refolding
HLB42_RS00575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HLB42_RS00580	COG3706	GGDEF domain
HLB42_RS00595	COG1051	belongs to the nudix hydrolase family
HLB42_RS00615	COG0612	Peptidase, M16
HLB42_RS00620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLB42_RS00635	COG1394	ATPase activity, coupled to movement of substances
HLB42_RS00640	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HLB42_RS00645	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HLB42_RS00650	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
HLB42_RS00655	COG1527	subunit (C
HLB42_RS00660	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HLB42_RS00665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLB42_RS00670	COG1269	ATP hydrolysis coupled proton transport
HLB42_RS00695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HLB42_RS00700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HLB42_RS00705	COG2188	Transcriptional regulator
HLB42_RS00710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLB42_RS00715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HLB42_RS00720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HLB42_RS00725	COG0586	Pfam SNARE associated Golgi protein
HLB42_RS00730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLB42_RS00735	COG0483	inositol monophosphate 1-phosphatase activity
HLB42_RS00750	COG1994	Peptidase M50
HLB42_RS00755	COG0617	tRNA 3'-terminal CCA addition
HLB42_RS00760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB42_RS00770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HLB42_RS00780	COG2197	response regulator
HLB42_RS00815	COG0726	polysaccharide deacetylase
HLB42_RS00830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HLB42_RS00845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLB42_RS00865	COG0587	DNA-directed DNA polymerase activity
HLB42_RS00885	COG0824	Thioesterase
HLB42_RS00890	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HLB42_RS00920	COG0717	Belongs to the dCTP deaminase family
HLB42_RS00970	COG2130	NADP-dependent
HLB42_RS00985	COG3842	ATPase activity
HLB42_RS00990	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLB42_RS01035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLB42_RS01075	COG0222	ribosome binding
HLB42_RS01080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HLB42_RS01085	COG0081	regulation of translation
HLB42_RS01090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HLB42_RS01095	COG0250	Participates in transcription elongation, termination and antitermination
HLB42_RS01100	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLB42_RS01105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLB42_RS01140	COG1132	(ABC) transporter
HLB42_RS01145	COG1132	(ABC) transporter
HLB42_RS01200	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS01205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLB42_RS01210	COG0702	epimerase
HLB42_RS01215	COG1012	belongs to the aldehyde dehydrogenase family
HLB42_RS01215	COG2030	dehydratase
HLB42_RS01235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB42_RS01240	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HLB42_RS01260	COG0305	Participates in initiation and elongation during chromosome replication
HLB42_RS01270	COG4968	Prepilin-type N-terminal cleavage methylation domain
HLB42_RS01285	COG3152	Membrane
HLB42_RS01290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLB42_RS01295	COG0140	phosphoribosyl-ATP diphosphatase activity
HLB42_RS01295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HLB42_RS01300	COG0107	imidazoleglycerol-phosphate synthase activity
HLB42_RS01325	COG0688	phosphatidylethanolamine metabolic process
HLB42_RS01340	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HLB42_RS01345	COG0540	Belongs to the ATCase OTCase family
HLB42_RS01355	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLB42_RS01365	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HLB42_RS01380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLB42_RS01390	COG0686	Belongs to the AlaDH PNT family
HLB42_RS01410	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HLB42_RS01445	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HLB42_RS01455	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HLB42_RS01470	COG0312	modulator of DNA gyrase
HLB42_RS01490	COG0564	pseudouridine synthase activity
HLB42_RS01495	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HLB42_RS01500	COG2226	methyltransferase
HLB42_RS01535	COG0557	exoribonuclease II activity
HLB42_RS01555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLB42_RS01575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB42_RS01585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLB42_RS01595	COG0284	orotidine-5'-phosphate decarboxylase activity
HLB42_RS01635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HLB42_RS01660	COG3206	protein involved in exopolysaccharide biosynthesis
HLB42_RS01660	COG0489	protein tyrosine kinase activity
HLB42_RS01685	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HLB42_RS01690	COG1085	galactose-1-phosphate uridylyltransferase
HLB42_RS01695	COG3345	alpha-galactosidase
HLB42_RS01705	COG0395	ABC-type sugar transport system, permease component
HLB42_RS01715	COG1653	transport
HLB42_RS01720	COG1349	DNA-binding transcription factor activity
HLB42_RS01725	COG1476	TRANSCRIPTIONal
HLB42_RS01735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HLB42_RS01740	COG0424	maF-like protein
HLB42_RS01745	COG1792	Involved in formation and maintenance of cell shape
HLB42_RS01755	COG0768	penicillin binding
HLB42_RS01780	COG2197	response regulator
HLB42_RS01805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HLB42_RS01825	COG0601	transmembrane transport
HLB42_RS01830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB42_RS01835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HLB42_RS01840	COG2339	peptidase activity
HLB42_RS01845	COG0314	molybdopterin synthase activity
HLB42_RS01860	COG0723	plastoquinol--plastocyanin reductase activity
HLB42_RS01870	COG3088	subunit of a heme lyase
HLB42_RS01875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB42_RS01885	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HLB42_RS01895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLB42_RS01910	COG0438	transferase activity, transferring glycosyl groups
HLB42_RS01915	COG2311	Membrane
HLB42_RS01920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLB42_RS01930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLB42_RS01940	COG0471	metal ion transport
HLB42_RS01940	COG3273	potassium ion transport
HLB42_RS01945	COG1607	acyl-coa hydrolase
HLB42_RS01955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLB42_RS01960	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLB42_RS01970	COG0666	response to abiotic stimulus
HLB42_RS01990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLB42_RS02000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLB42_RS02005	COG0336	Belongs to the RNA methyltransferase TrmD family
HLB42_RS02010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HLB42_RS02015	COG1837	Belongs to the UPF0109 family
HLB42_RS02020	COG0228	four-way junction DNA binding
HLB42_RS02045	COG1116	anion transmembrane transporter activity
HLB42_RS02050	COG0697	spore germination
HLB42_RS02065	COG1803	Methylglyoxal synthase
HLB42_RS02070	COG1040	competence protein
HLB42_RS02100	COG1051	belongs to the nudix hydrolase family
HLB42_RS02100	COG1056	cytidyltransferase-related domain
HLB42_RS02110	COG1832	CoA-binding protein
HLB42_RS02115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HLB42_RS02175	COG2226	methyltransferase
HLB42_RS02190	COG2315	Protein conserved in bacteria
HLB42_RS02215	COG1737	Transcriptional regulator
HLB42_RS02225	COG1175	transmembrane transport
HLB42_RS02230	COG0395	ABC-type sugar transport system, permease component
HLB42_RS02235	COG1472	Belongs to the glycosyl hydrolase 3 family
HLB42_RS02260	COG1414	Transcriptional regulator
HLB42_RS02270	COG0747	negative chemotaxis
HLB42_RS02275	COG0601	transmembrane transport
HLB42_RS02280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB42_RS02290	COG0747	negative chemotaxis
HLB42_RS02305	COG0006	proline dipeptidase activity
HLB42_RS02315	COG0601	transmembrane transport
HLB42_RS02325	COG0747	negative chemotaxis
HLB42_RS02355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLB42_RS02370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB42_RS02420	COG0454	-acetyltransferase
HLB42_RS02420	COG0456	acetyltransferase
HLB42_RS02425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLB42_RS02445	COG4133	protoheme IX ABC transporter activity
HLB42_RS02450	COG0785	Cytochrome C biogenesis protein
HLB42_RS02455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLB42_RS02465	COG0512	Glutamine amidotransferase of anthranilate synthase
HLB42_RS02470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLB42_RS02475	COG0473	3-isopropylmalate dehydrogenase activity
HLB42_RS02485	COG1522	sequence-specific DNA binding
HLB42_RS02510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLB42_RS02515	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HLB42_RS02525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLB42_RS02530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HLB42_RS02550	COG1404	Belongs to the peptidase S8 family
HLB42_RS02560	COG1404	Belongs to the peptidase S8 family
HLB42_RS02585	COG0747	negative chemotaxis
HLB42_RS02595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLB42_RS02605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLB42_RS02620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HLB42_RS02625	COG2046	Belongs to the sulfate adenylyltransferase family
HLB42_RS02630	COG0175	sulfate reduction
HLB42_RS02635	COG0529	Catalyzes the synthesis of activated sulfate
HLB42_RS02640	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLB42_RS02650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLB42_RS02655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HLB42_RS02660	COG0586	Pfam SNARE associated Golgi protein
HLB42_RS02670	COG1073	alpha beta
HLB42_RS02690	COG4948	Mandelate Racemase Muconate Lactonizing
HLB42_RS02705	COG4956	integral membrane protein (PIN domain superfamily)
HLB42_RS02730	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLB42_RS02735	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLB42_RS02735	COG1796	DNA polymerase
HLB42_RS02750	COG0237	dephospho-CoA kinase activity
HLB42_RS02755	COG0504	CTP synthase activity
HLB42_RS02760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLB42_RS02770	COG3422	double-strand break repair
HLB42_RS02785	COG1960	acyl-CoA dehydrogenase activity
HLB42_RS02790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLB42_RS02795	COG1960	acyl-CoA dehydrogenase activity
HLB42_RS02825	COG0129	dihydroxy-acid dehydratase activity
HLB42_RS02835	COG0134	indole-3-glycerol-phosphate synthase activity
HLB42_RS02840	COG5002	protein histidine kinase activity
HLB42_RS02845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLB42_RS02850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLB42_RS02855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLB42_RS02860	COG0649	NAD binding
HLB42_RS02865	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HLB42_RS02870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HLB42_RS02875	COG1034	ATP synthesis coupled electron transport
HLB42_RS02880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HLB42_RS02885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLB42_RS02890	COG0839	Belongs to the complex I subunit 6 family
HLB42_RS02895	COG0713	ATP synthesis coupled electron transport
HLB42_RS02900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLB42_RS02905	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLB42_RS02910	COG1007	ATP synthesis coupled electron transport
HLB42_RS02925	COG0673	inositol 2-dehydrogenase activity
HLB42_RS02935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLB42_RS02945	COG1193	negative regulation of DNA recombination
HLB42_RS02965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB42_RS02970	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HLB42_RS02985	COG0395	ABC-type sugar transport system, permease component
HLB42_RS02990	COG0482	sulfurtransferase activity
HLB42_RS02995	COG0745	RESPONSE REGULATOR receiver
HLB42_RS03000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB42_RS03015	COG0300	oxidoreductase activity
HLB42_RS03030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLB42_RS03055	COG0193	aminoacyl-tRNA hydrolase activity
HLB42_RS03060	COG1363	Peptidase, m42
HLB42_RS03065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB42_RS03070	COG2124	cytochrome p450
HLB42_RS03085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLB42_RS03110	COG3706	GGDEF domain
HLB42_RS03135	COG0505	Belongs to the CarA family
HLB42_RS03145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HLB42_RS03175	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HLB42_RS03205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLB42_RS03220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLB42_RS03250	COG2807	transmembrane transport
HLB42_RS03265	COG4302	ethanolamine ammonia-lyase activity
HLB42_RS03280	COG0477	Major facilitator Superfamily
HLB42_RS03290	COG3842	ATPase activity
HLB42_RS03300	COG1840	ABC-type Fe3 transport system, periplasmic component
HLB42_RS03310	COG3290	protein histidine kinase activity
HLB42_RS03325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLB42_RS03330	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HLB42_RS03335	COG2080	2 iron, 2 sulfur cluster binding
HLB42_RS03345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLB42_RS03355	COG0335	large ribosomal subunit rRNA binding
HLB42_RS03370	COG0321	lipoyl(octanoyl) transferase activity
HLB42_RS03375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLB42_RS03390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HLB42_RS03395	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HLB42_RS03400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HLB42_RS03405	COG1660	Displays ATPase and GTPase activities
HLB42_RS03415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLB42_RS03415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLB42_RS03420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HLB42_RS03455	COG1304	FMN binding
HLB42_RS03465	COG0632	four-way junction helicase activity
HLB42_RS03470	COG1309	transcriptional regulator
HLB42_RS03475	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HLB42_RS03480	COG3426	butyrate kinase activity
HLB42_RS03490	COG0456	acetyltransferase
HLB42_RS03500	COG2409	Drug exporters of the RND superfamily
HLB42_RS03515	COG0561	phosphatase activity
HLB42_RS03520	COG0384	phenazine biosynthesis protein PhzF
HLB42_RS03535	COG1126	abc transporter atp-binding protein
HLB42_RS03540	COG2358	TRAP transporter, solute receptor (TAXI family
HLB42_RS03550	COG0628	permease
HLB42_RS03570	COG3265	gluconokinase activity
HLB42_RS03580	COG4294	response to UV
HLB42_RS03590	COG1404	Belongs to the peptidase S8 family
HLB42_RS03605	COG1100	Small GTP-binding protein
HLB42_RS03610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLB42_RS03620	COG2111	Na H antiporter
HLB42_RS03625	COG1006	Multisubunit Na H antiporter MnhC subunit
HLB42_RS03640	COG2212	antiporter activity
HLB42_RS03645	COG1320	monovalent cation:proton antiporter activity
HLB42_RS03650	COG0295	cytidine deaminase activity
HLB42_RS03655	COG1253	flavin adenine dinucleotide binding
HLB42_RS03660	COG0604	alcohol dehydrogenase
HLB42_RS03665	COG1404	Belongs to the peptidase S8 family
HLB42_RS03680	COG0494	nUDIX hydrolase
HLB42_RS03685	COG2318	DinB family
HLB42_RS03690	COG1694	Mazg nucleotide pyrophosphohydrolase
HLB42_RS03700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLB42_RS03705	COG0668	transmembrane transport
HLB42_RS03725	COG0018	arginyl-trna synthetase
HLB42_RS03740	COG0287	Prephenate dehydrogenase
HLB42_RS03745	COG1131	(ABC) transporter
HLB42_RS03755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLB42_RS03760	COG1121	(ABC) transporter
HLB42_RS03765	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLB42_RS03790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLB42_RS03790	COG1213	nucleotidyl transferase
HLB42_RS03815	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HLB42_RS03825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB42_RS03830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB42_RS03835	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HLB42_RS03850	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HLB42_RS03865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HLB42_RS03870	COG0517	IMP dehydrogenase activity
HLB42_RS03870	COG0516	GMP reductase activity
HLB42_RS03885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLB42_RS03895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLB42_RS03900	COG2873	o-acetylhomoserine
HLB42_RS03915	COG0735	belongs to the Fur family
HLB42_RS03930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLB42_RS03935	COG1562	ergosterol biosynthetic process
HLB42_RS03940	COG0737	Belongs to the 5'-nucleotidase family
HLB42_RS03950	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HLB42_RS03955	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLB42_RS03960	COG1435	thymidine kinase activity
HLB42_RS03965	COG0254	rRNA binding
HLB42_RS03970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLB42_RS04000	COG2351	hydroxyisourate hydrolase activity
HLB42_RS04015	COG0484	heat shock protein binding
HLB42_RS04025	COG2272	Belongs to the type-B carboxylesterase lipase family
HLB42_RS04030	COG0673	inositol 2-dehydrogenase activity
HLB42_RS04050	COG2255	four-way junction helicase activity
HLB42_RS04075	COG0776	regulation of translation
HLB42_RS04080	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLB42_RS04085	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HLB42_RS04095	COG1185	polyribonucleotide nucleotidyltransferase activity
HLB42_RS04100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB42_RS04115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLB42_RS04120	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HLB42_RS04130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HLB42_RS04140	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HLB42_RS04145	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLB42_RS04150	COG2205	protein histidine kinase activity
HLB42_RS04155	COG0745	RESPONSE REGULATOR receiver
HLB42_RS04175	COG1136	(ABC) transporter
HLB42_RS04180	COG1136	(ABC) transporter
HLB42_RS04180	COG0577	efflux transmembrane transporter activity
HLB42_RS04190	COG4636	protein conserved in cyanobacteria
HLB42_RS04215	COG0151	Belongs to the GarS family
HLB42_RS04220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLB42_RS04245	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HLB42_RS04260	COG0746	molybdenum cofactor guanylyltransferase activity
HLB42_RS04275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLB42_RS04285	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HLB42_RS04290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HLB42_RS04295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLB42_RS04300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLB42_RS04310	COG1470	cell adhesion involved in biofilm formation
HLB42_RS04310	COG0366	Alpha amylase catalytic
HLB42_RS04320	COG2197	response regulator
HLB42_RS04330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB42_RS04350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB42_RS04355	COG0667	Aldo Keto reductase
HLB42_RS04375	COG0778	Nitroreductase
HLB42_RS04395	COG0542	response to heat
HLB42_RS04415	COG0640	Transcriptional regulator
HLB42_RS04420	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HLB42_RS04455	COG0542	response to heat
HLB42_RS04490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLB42_RS04490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLB42_RS04515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLB42_RS04525	COG0747	negative chemotaxis
HLB42_RS04530	COG0601	transmembrane transport
HLB42_RS04535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB42_RS04545	COG0181	hydroxymethylbilane synthase activity
HLB42_RS04555	COG2050	protein possibly involved in aromatic compounds catabolism
HLB42_RS04580	COG0784	Response regulator, receiver
HLB42_RS04585	COG4251	negative regulation of phosphorylation
HLB42_RS04600	COG1131	(ABC) transporter
HLB42_RS04625	COG0746	molybdenum cofactor guanylyltransferase activity
HLB42_RS04630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLB42_RS04650	COG3655	Transcriptional regulator
HLB42_RS04655	COG0561	phosphatase activity
HLB42_RS04660	COG0736	holo-[acyl-carrier-protein] synthase activity
HLB42_RS04700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLB42_RS04710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLB42_RS04715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HLB42_RS04720	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HLB42_RS04730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLB42_RS04735	COG0174	glutamine synthetase
HLB42_RS04770	COG2364	Membrane
HLB42_RS04780	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HLB42_RS04785	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HLB42_RS04805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB42_RS04810	COG0247	lactate metabolic process
HLB42_RS04815	COG0277	FAD linked oxidase domain protein
HLB42_RS04830	COG0737	Belongs to the 5'-nucleotidase family
HLB42_RS04840	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HLB42_RS04870	COG1960	acyl-CoA dehydrogenase activity
HLB42_RS04880	COG0515	serine threonine protein kinase
HLB42_RS04880	COG2815	serine threonine protein kinase
HLB42_RS04885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLB42_RS04890	COG0492	ferredoxin-NADP+ reductase activity
HLB42_RS04895	COG0493	'glutamate synthase
HLB42_RS04900	COG0387	Pfam Sodium calcium exchanger
HLB42_RS04905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLB42_RS04910	COG0537	adenosine 5'-monophosphoramidase activity
HLB42_RS04925	COG1968	undecaprenyl-diphosphatase activity
HLB42_RS04935	COG1309	transcriptional regulator
HLB42_RS04940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLB42_RS04960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLB42_RS04980	COG4948	Mandelate Racemase Muconate Lactonizing
HLB42_RS04990	COG0601	transmembrane transport
HLB42_RS04995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB42_RS05000	COG0747	negative chemotaxis
HLB42_RS05010	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HLB42_RS05015	COG1737	Transcriptional regulator
HLB42_RS05020	COG0243	molybdopterin cofactor binding
HLB42_RS05030	COG0251	oxidation-reduction process
HLB42_RS05050	COG1846	Transcriptional regulator
HLB42_RS05055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB42_RS05065	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HLB42_RS05070	COG2967	ApaG domain
HLB42_RS05075	COG1363	Peptidase, m42
HLB42_RS05090	COG0009	L-threonylcarbamoyladenylate synthase
HLB42_RS05095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HLB42_RS05110	COG0791	NLP P60 protein
HLB42_RS05125	COG0471	metal ion transport
HLB42_RS05125	COG3273	potassium ion transport
HLB42_RS05130	COG0066	3-isopropylmalate dehydratase activity
HLB42_RS05135	COG0473	3-isopropylmalate dehydrogenase activity
HLB42_RS05145	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HLB42_RS05150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLB42_RS05170	COG0183	Belongs to the thiolase family
HLB42_RS05185	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB42_RS05185	COG1024	Enoyl-CoA hydratase
HLB42_RS05190	COG3173	Aminoglycoside phosphotransferase
HLB42_RS05200	COG0822	iron-sulfur transferase activity
HLB42_RS05210	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLB42_RS05215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB42_RS05220	COG2814	Major facilitator Superfamily
HLB42_RS05235	COG0525	valine-tRNA ligase activity
HLB42_RS05240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLB42_RS05250	COG2072	flavoprotein involved in K transport
HLB42_RS05260	COG1660	Displays ATPase and GTPase activities
HLB42_RS05275	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HLB42_RS05295	COG2819	hydrolase of the alpha beta superfamily
HLB42_RS05300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HLB42_RS05315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HLB42_RS05320	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HLB42_RS05325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HLB42_RS05330	COG1450	Type ii and iii secretion system protein
HLB42_RS05365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLB42_RS05375	COG1461	Dihydroxyacetone kinase
HLB42_RS05385	COG0477	Major facilitator Superfamily
HLB42_RS05395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLB42_RS05410	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HLB42_RS05415	COG0049	tRNA binding
HLB42_RS05420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HLB42_RS05435	COG0051	transcription antitermination factor activity, RNA binding
HLB42_RS05440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HLB42_RS05445	COG0088	Forms part of the polypeptide exit tunnel
HLB42_RS05450	COG0089	rRNA binding
HLB42_RS05455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HLB42_RS05460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HLB42_RS05465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HLB42_RS05470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HLB42_RS05475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HLB42_RS05480	COG0255	Belongs to the universal ribosomal protein uL29 family
HLB42_RS05485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HLB42_RS05490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HLB42_RS05495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HLB42_RS05500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HLB42_RS05505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HLB42_RS05510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HLB42_RS05515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HLB42_RS05520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HLB42_RS05525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HLB42_RS05530	COG1841	ribosomal large subunit assembly
HLB42_RS05535	COG0200	Binds to the 23S rRNA
HLB42_RS05540	COG0201	protein transport
HLB42_RS05545	COG0563	adenylate kinase activity
HLB42_RS05565	COG0714	Associated with various cellular activities
HLB42_RS05580	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HLB42_RS05585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HLB42_RS05590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HLB42_RS05595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HLB42_RS05600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HLB42_RS05605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HLB42_RS05610	COG0202	RNA polymerase activity
HLB42_RS05615	COG0203	ribosomal protein L17
HLB42_RS05620	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HLB42_RS05635	COG0363	glucosamine-6-phosphate deaminase activity
HLB42_RS05640	COG1486	melibiose metabolic process
HLB42_RS05645	COG4608	Belongs to the ABC transporter superfamily
HLB42_RS05650	COG0444	Belongs to the ABC transporter superfamily
HLB42_RS05655	COG0601	transmembrane transport
HLB42_RS05665	COG1609	Transcriptional regulator
HLB42_RS05680	COG0328	RNA-DNA hybrid ribonuclease activity
HLB42_RS05695	COG0824	Thioesterase
HLB42_RS05700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HLB42_RS05705	COG3942	CHAP domain
HLB42_RS05705	COG1388	LysM domain
HLB42_RS05725	COG1774	PSP1 C-terminal conserved region
HLB42_RS05730	COG0251	oxidation-reduction process
HLB42_RS05735	COG0631	protein serine/threonine phosphatase activity
HLB42_RS05740	COG0154	amidase activity
HLB42_RS05745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLB42_RS05755	COG1187	pseudouridine synthase activity
HLB42_RS05760	COG1760	l-serine dehydratase
HLB42_RS05775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB42_RS05780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLB42_RS05810	COG3118	belongs to the thioredoxin family
HLB42_RS05825	COG0416	fatty acid biosynthetic process
HLB42_RS05830	COG2308	Evidence 4 Homologs of previously reported genes of
HLB42_RS05840	COG1305	Transglutaminase-like
HLB42_RS05850	COG0300	oxidoreductase activity
HLB42_RS05855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLB42_RS05870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HLB42_RS05875	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HLB42_RS05880	COG1546	Belongs to the CinA family
HLB42_RS05880	COG1058	Belongs to the CinA family
HLB42_RS05900	COG4585	Histidine kinase
HLB42_RS05905	COG2197	response regulator
HLB42_RS05915	COG2608	mercury ion transmembrane transporter activity
HLB42_RS05925	COG0488	(ABC) transporter
HLB42_RS05945	COG1252	NADH dehydrogenase
HLB42_RS05950	COG5322	oxidoreductase activity
HLB42_RS05960	COG2329	Antibiotic biosynthesis monooxygenase
HLB42_RS05970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLB42_RS05975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLB42_RS05980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLB42_RS05995	COG1573	uracil-dna glycosylase
HLB42_RS06005	COG1490	D-aminoacyl-tRNA deacylase activity
HLB42_RS06010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLB42_RS06025	COG0738	Major facilitator superfamily
HLB42_RS06030	COG1609	Transcriptional regulator
HLB42_RS06055	COG0523	cobalamin synthesis protein
HLB42_RS06065	COG2050	protein possibly involved in aromatic compounds catabolism
HLB42_RS06070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLB42_RS06075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB42_RS06110	COG0142	geranyltranstransferase activity
HLB42_RS06115	COG3396	Phenylacetate-CoA oxygenase
HLB42_RS06125	COG3396	Phenylacetate-CoA oxygenase
HLB42_RS06130	COG2151	metal-sulfur cluster biosynthetic enzyme
HLB42_RS06145	COG0366	Alpha amylase catalytic
HLB42_RS06185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB42_RS06190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HLB42_RS06210	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLB42_RS06210	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLB42_RS06220	COG4989	oxidoreductase activity
HLB42_RS06245	COG0495	leucyl-tRNA aminoacylation
HLB42_RS06270	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLB42_RS06310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLB42_RS06310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLB42_RS06315	COG1914	H( )-stimulated, divalent metal cation uptake system
HLB42_RS06325	COG3870	Protein conserved in bacteria
HLB42_RS06330	COG0210	DNA helicase
HLB42_RS06335	COG0667	Aldo Keto reductase
HLB42_RS06375	COG2816	NAD+ diphosphatase activity
HLB42_RS06390	COG0247	lactate metabolic process
HLB42_RS06390	COG2181	nitrate reductase activity
HLB42_RS06395	COG1307	EDD domain protein, DegV family
HLB42_RS06405	COG4712	double-strand break repair protein
HLB42_RS06410	COG0131	Imidazoleglycerol-phosphate dehydratase
HLB42_RS06415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HLB42_RS06420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLB42_RS06440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB42_RS06460	COG1695	Transcriptional regulator
HLB42_RS06475	COG1252	NADH dehydrogenase
HLB42_RS06510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB42_RS06525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLB42_RS06530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HLB42_RS06565	COG3178	'Phosphotransferase
HLB42_RS06575	COG0788	formyltetrahydrofolate deformylase activity
HLB42_RS06590	COG1254	Belongs to the acylphosphatase family
HLB42_RS06600	COG0704	Plays a role in the regulation of phosphate uptake
HLB42_RS06605	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HLB42_RS06610	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HLB42_RS06630	COG0113	porphobilinogen synthase activity
HLB42_RS06655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLB42_RS06660	COG1053	succinate dehydrogenase
HLB42_RS06670	COG2009	succinate dehydrogenase
HLB42_RS06765	COG3842	ATPase activity
HLB42_RS06770	COG0390	transport system, permease component
HLB42_RS06780	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLB42_RS06795	COG4946	Tricorn protease homolog
HLB42_RS06795	COG0793	Belongs to the peptidase S41A family
HLB42_RS06810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLB42_RS06815	COG0395	ABC-type sugar transport system, permease component
HLB42_RS06820	COG1175	transmembrane transport
HLB42_RS06835	COG0165	Argininosuccinate lyase
HLB42_RS06845	COG3706	GGDEF domain
HLB42_RS06860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HLB42_RS06870	COG0163	prenyltransferase activity
HLB42_RS06875	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HLB42_RS06880	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HLB42_RS06890	COG1024	Enoyl-CoA hydratase
HLB42_RS06890	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB42_RS06905	COG0183	Belongs to the thiolase family
HLB42_RS06910	COG2337	Toxic component of a toxin-antitoxin (TA) module
HLB42_RS06915	COG2336	PFAM SpoVT AbrB
HLB42_RS06925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLB42_RS06930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HLB42_RS06940	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HLB42_RS06955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HLB42_RS06965	COG0028	Belongs to the TPP enzyme family
HLB42_RS06975	COG0513	Belongs to the DEAD box helicase family
HLB42_RS06985	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB42_RS06985	COG2247	cell wall binding repeat
HLB42_RS07000	COG4221	oxidoreductase activity
HLB42_RS07005	COG0492	ferredoxin-NADP+ reductase activity
HLB42_RS07010	COG1011	Hydrolase
HLB42_RS07020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLB42_RS07025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HLB42_RS07035	COG2337	Toxic component of a toxin-antitoxin (TA) module
HLB42_RS07050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLB42_RS07050	COG0072	phenylalanine-tRNA ligase activity
HLB42_RS07055	COG0494	nUDIX hydrolase
HLB42_RS07080	COG0745	RESPONSE REGULATOR receiver
HLB42_RS07100	COG0242	peptide deformylase activity
HLB42_RS07105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLB42_RS07110	COG0656	L-ascorbic acid biosynthetic process
HLB42_RS07120	COG5412	phage tail tape measure protein
HLB42_RS07155	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HLB42_RS07160	COG0297	glycogen (starch) synthase activity
HLB42_RS07190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLB42_RS07195	COG1760	l-serine dehydratase
HLB42_RS07205	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HLB42_RS07215	COG1228	amidohydrolase
HLB42_RS07220	COG2986	histidine ammonia-lyase
HLB42_RS07225	COG1605	Chorismate mutase
HLB42_RS07225	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HLB42_RS07240	COG1131	(ABC) transporter
HLB42_RS07245	COG2032	superoxide dismutase activity
HLB42_RS07255	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HLB42_RS07265	COG0196	riboflavin kinase activity
HLB42_RS07275	COG0037	tRNA processing
HLB42_RS07275	COG0590	tRNA wobble adenosine to inosine editing
HLB42_RS07280	COG0019	diaminopimelate decarboxylase activity
HLB42_RS07285	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HLB42_RS07290	COG1692	metallophosphoesterase
HLB42_RS07305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLB42_RS07330	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB42_RS07355	COG0601	transmembrane transport
HLB42_RS07360	COG0747	negative chemotaxis
HLB42_RS07370	COG1653	transport
HLB42_RS07375	COG1472	Belongs to the glycosyl hydrolase 3 family
HLB42_RS07380	COG1307	EDD domain protein, DegV family
HLB42_RS07395	COG1247	-acetyltransferase
HLB42_RS07405	COG0052	Belongs to the universal ribosomal protein uS2 family
HLB42_RS07410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HLB42_RS07415	COG0528	UMP kinase activity
HLB42_RS07420	COG0233	cytoplasmic translational termination
HLB42_RS07425	COG0575	Belongs to the CDS family
HLB42_RS07450	COG0012	GTP binding
HLB42_RS07455	COG3706	GGDEF domain
HLB42_RS07460	COG0363	glucosamine-6-phosphate deaminase activity
HLB42_RS07470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HLB42_RS07475	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HLB42_RS07480	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HLB42_RS07500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HLB42_RS07505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLB42_RS07520	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HLB42_RS07550	COG0519	Catalyzes the synthesis of GMP from XMP
HLB42_RS07550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLB42_RS07555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HLB42_RS07560	COG3012	SEC-C Motif Domain Protein
HLB42_RS07565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLB42_RS07580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB42_RS07585	COG0534	Mate efflux family protein
HLB42_RS07590	COG0655	NAD(P)H dehydrogenase (quinone) activity
HLB42_RS07600	COG0477	Major facilitator Superfamily
HLB42_RS07605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HLB42_RS07620	COG0672	)-iron permease
HLB42_RS07630	COG1959	2 iron, 2 sulfur cluster binding
HLB42_RS07635	COG1494	fructose-1,6-bisphosphatase
HLB42_RS07755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLB42_RS07895	COG0328	RNA-DNA hybrid ribonuclease activity
HLB42_RS07940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HLB42_RS07950	COG3383	formate dehydrogenase (NAD+) activity
HLB42_RS07965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLB42_RS07975	COG1051	belongs to the nudix hydrolase family
HLB42_RS07980	COG3956	TIGRFAM MazG family protein
HLB42_RS07995	COG4221	oxidoreductase activity
HLB42_RS08000	COG1959	2 iron, 2 sulfur cluster binding
HLB42_RS08005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLB42_RS08005	COG1017	nitric oxide dioxygenase activity
HLB42_RS08010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HLB42_RS08045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HLB42_RS08045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HLB42_RS08050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLB42_RS08055	COG1643	Atp-dependent helicase
HLB42_RS08060	COG2226	methyltransferase
HLB42_RS08065	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HLB42_RS08070	COG1597	lipid kinase activity
HLB42_RS08080	COG0017	Asparaginyl-tRNA synthetase
HLB42_RS08085	COG0438	transferase activity, transferring glycosyl groups
HLB42_RS08090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HLB42_RS08100	COG1295	ribonuclease BN
HLB42_RS08110	COG0281	malic enzyme
HLB42_RS08120	COG0183	Belongs to the thiolase family
HLB42_RS08125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLB42_RS08135	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HLB42_RS08140	COG0006	proline dipeptidase activity
HLB42_RS08145	COG0045	succinate-CoA ligase (ADP-forming) activity
HLB42_RS08170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HLB42_RS08175	COG0124	histidyl-tRNA synthetase
HLB42_RS08185	COG1597	lipid kinase activity
HLB42_RS08185	COG1803	Methylglyoxal synthase
HLB42_RS08195	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HLB42_RS08210	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLB42_RS08225	COG0791	NLP P60 protein
HLB42_RS08240	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HLB42_RS08245	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HLB42_RS08250	COG0745	RESPONSE REGULATOR receiver
HLB42_RS08255	COG0739	heme binding
HLB42_RS08260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HLB42_RS08270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLB42_RS08280	COG0438	transferase activity, transferring glycosyl groups
HLB42_RS08285	COG0406	alpha-ribazole phosphatase activity
HLB42_RS08295	COG0322	excinuclease ABC activity
HLB42_RS08300	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS08315	COG1609	Transcriptional regulator
HLB42_RS08325	COG1175	transmembrane transport
HLB42_RS08330	COG0395	ABC-type sugar transport system, permease component
HLB42_RS08345	COG3507	Belongs to the glycosyl hydrolase 43 family
HLB42_RS08350	COG1472	Belongs to the glycosyl hydrolase 3 family
HLB42_RS08365	COG0126	phosphoglycerate kinase activity
HLB42_RS08370	COG0149	triose-phosphate isomerase activity
HLB42_RS08375	COG2182	Extracellular solute-binding protein
HLB42_RS08380	COG1164	Oligoendopeptidase f
HLB42_RS08385	COG0189	ligase activity
HLB42_RS08400	COG0066	3-isopropylmalate dehydratase activity
HLB42_RS08410	COG2217	Heavy metal translocating P-type atpase
HLB42_RS08425	COG0640	Transcriptional regulator
HLB42_RS08445	COG0194	GDP metabolic process
HLB42_RS08450	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HLB42_RS08460	COG1842	Phage shock protein A
HLB42_RS08475	COG0515	serine threonine protein kinase
HLB42_RS08475	COG2815	serine threonine protein kinase
HLB42_RS08480	COG1104	cysteine desulfurase activity
HLB42_RS08505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HLB42_RS08515	COG0783	Belongs to the Dps family
HLB42_RS08530	COG0667	Aldo Keto reductase
HLB42_RS08545	COG0489	protein tyrosine kinase activity
HLB42_RS08555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLB42_RS08575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB42_RS08580	COG0154	amidase activity
HLB42_RS08585	COG0077	Prephenate dehydratase
HLB42_RS08585	COG1605	Chorismate mutase
HLB42_RS08590	COG4221	oxidoreductase activity
HLB42_RS08610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HLB42_RS08635	COG0756	dUTP diphosphatase activity
HLB42_RS08640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLB42_RS08655	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HLB42_RS08660	COG0552	protein localization to endoplasmic reticulum
HLB42_RS08665	COG4585	Histidine kinase
HLB42_RS08675	COG0167	dihydroorotate dehydrogenase activity
HLB42_RS08680	COG1959	2 iron, 2 sulfur cluster binding
HLB42_RS08685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLB42_RS08700	COG1918	ferrous iron import across plasma membrane
HLB42_RS08700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HLB42_RS08710	COG0564	pseudouridine synthase activity
HLB42_RS08715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLB42_RS08725	COG4269	membrane
HLB42_RS08730	COG0402	S-adenosylhomocysteine deaminase activity
HLB42_RS08740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HLB42_RS08745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLB42_RS08750	COG2045	Belongs to the ComB family
HLB42_RS08795	COG3001	Fructosamine kinase
HLB42_RS08800	COG2124	cytochrome p450
HLB42_RS08810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HLB42_RS08825	COG1132	(ABC) transporter
HLB42_RS08830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLB42_RS08845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLB42_RS08890	COG0582	viral genome integration into host DNA
HLB42_RS08950	COG0210	DNA helicase
HLB42_RS08975	COG1111	helicase
HLB42_RS08975	COG1205	dead DEAH box helicase
HLB42_RS08980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLB42_RS09015	COG1401	restriction endodeoxyribonuclease activity
HLB42_RS09015	COG1401	restriction endodeoxyribonuclease activity
HLB42_RS09025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLB42_RS09025	COG2813	Specifically methylates the guanine in position
HLB42_RS09035	COG0596	Alpha beta hydrolase
HLB42_RS09065	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS09080	COG0475	glutathione-regulated potassium exporter activity
HLB42_RS09090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HLB42_RS09110	COG1754	DNA topoisomerase type I activity
HLB42_RS09110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLB42_RS09120	COG0728	peptidoglycan biosynthetic process
HLB42_RS09145	COG3973	AAA domain
HLB42_RS09150	COG3457	Alanine racemase
HLB42_RS09170	COG0585	pseudouridine synthase activity
HLB42_RS09180	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLB42_RS09190	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLB42_RS09205	COG0497	DNA recombination
HLB42_RS09215	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HLB42_RS09220	COG3833	ABC-type maltose transport systems, permease component
HLB42_RS09225	COG1175	transmembrane transport
HLB42_RS09240	COG2814	Major facilitator Superfamily
HLB42_RS09255	COG1864	DNA RNA non-specific endonuclease
HLB42_RS09255	COG3591	Belongs to the peptidase S1B family
HLB42_RS09270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HLB42_RS09275	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLB42_RS09280	COG1653	transport
HLB42_RS09315	COG0714	Associated with various cellular activities
HLB42_RS09360	COG1022	Amp-dependent synthetase and ligase
HLB42_RS09370	COG0318	PFAM AMP-dependent synthetase and ligase
HLB42_RS09380	COG0702	epimerase
HLB42_RS09390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLB42_RS09395	COG1678	Uncharacterized ACR, COG1678
HLB42_RS09400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HLB42_RS09415	COG0101	tRNA pseudouridine synthase activity
HLB42_RS09420	COG1196	nuclear chromosome segregation
HLB42_RS09420	COG0739	heme binding
HLB42_RS09420	COG0741	lytic transglycosylase activity
HLB42_RS09430	COG1695	Transcriptional regulator
HLB42_RS09445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HLB42_RS09825	COG2197	response regulator
HLB42_RS09830	COG4585	Histidine kinase
HLB42_RS09840	COG0842	Transport permease protein
HLB42_RS09845	COG1131	(ABC) transporter
HLB42_RS09870	COG0442	prolyl-tRNA aminoacylation
HLB42_RS09875	COG2094	Belongs to the DNA glycosylase MPG family
HLB42_RS09880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLB42_RS09885	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HLB42_RS09895	COG4555	ABC transporter
HLB42_RS09930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB42_RS09940	COG0494	nUDIX hydrolase
HLB42_RS09955	COG1960	acyl-CoA dehydrogenase activity
HLB42_RS09965	COG0765	amino acid transport
HLB42_RS09970	COG1185	polyribonucleotide nucleotidyltransferase activity
HLB42_RS09980	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLB42_RS09990	COG1136	(ABC) transporter
HLB42_RS09995	COG1902	pentaerythritol trinitrate reductase activity
HLB42_RS10025	COG1131	(ABC) transporter
HLB42_RS10030	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HLB42_RS10045	COG1316	TRANSCRIPTIONal
HLB42_RS10055	COG0366	Alpha amylase catalytic
HLB42_RS10060	COG2815	serine threonine protein kinase
HLB42_RS10060	COG0515	serine threonine protein kinase
HLB42_RS10070	COG0681	Belongs to the peptidase S26 family
HLB42_RS10080	COG0646	methionine synthase
HLB42_RS10080	COG1410	methionine synthase
HLB42_RS10090	COG0753	catalase activity
HLB42_RS10095	COG0735	belongs to the Fur family
HLB42_RS10115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB42_RS10120	COG0601	transmembrane transport
HLB42_RS10125	COG0747	negative chemotaxis
HLB42_RS10145	COG2843	Capsule synthesis protein
HLB42_RS10190	COG1131	(ABC) transporter
HLB42_RS10200	COG3842	ATPase activity
HLB42_RS10210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HLB42_RS10225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLB42_RS10245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLB42_RS10255	COG0318	PFAM AMP-dependent synthetase and ligase
HLB42_RS10260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HLB42_RS10265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB42_RS10265	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HLB42_RS10270	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HLB42_RS10270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB42_RS10275	COG0473	3-isopropylmalate dehydrogenase activity
HLB42_RS10285	COG0626	cystathionine gamma-synthase activity
HLB42_RS10290	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS10295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HLB42_RS10300	COG0750	zinc metalloprotease
HLB42_RS10320	COG1668	transmembrane transport
HLB42_RS10350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLB42_RS10375	COG0488	(ABC) transporter
HLB42_RS10385	COG2814	Major facilitator Superfamily
HLB42_RS10405	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HLB42_RS10435	COG3191	aminopeptidase activity
HLB42_RS10440	COG1164	Oligoendopeptidase f
HLB42_RS10470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLB42_RS10480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLB42_RS10485	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HLB42_RS10490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HLB42_RS10495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLB42_RS10505	COG0330	HflC and HflK could
HLB42_RS10510	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HLB42_RS10525	COG4085	toxin activity
HLB42_RS10525	COG1525	nuclease
HLB42_RS10525	COG0737	Belongs to the 5'-nucleotidase family
HLB42_RS10535	COG1047	Peptidyl-prolyl cis-trans
HLB42_RS10540	COG0017	Asparaginyl-tRNA synthetase
HLB42_RS10555	COG0826	peptidase U32
HLB42_RS10575	COG2030	dehydratase
HLB42_RS10580	COG2301	Belongs to the HpcH HpaI aldolase family
HLB42_RS10590	COG1131	(ABC) transporter
HLB42_RS10595	COG0850	regulation of cytokinetic process
HLB42_RS10600	COG0779	Required for maturation of 30S ribosomal subunits
HLB42_RS10605	COG0195	Participates in both transcription termination and antitermination
HLB42_RS10615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HLB42_RS10625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLB42_RS10625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLB42_RS10630	COG0667	Aldo Keto reductase
HLB42_RS10640	COG0793	Belongs to the peptidase S41A family
HLB42_RS10655	COG1309	transcriptional regulator
HLB42_RS10660	COG0539	negative regulation of cytoplasmic translation
HLB42_RS10675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLB42_RS10680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLB42_RS10685	COG0142	geranyltranstransferase activity
HLB42_RS10720	COG0670	Belongs to the BI1 family
HLB42_RS10745	COG1381	Involved in DNA repair and RecF pathway recombination
HLB42_RS10750	COG4251	negative regulation of phosphorylation
HLB42_RS10760	COG2264	protein methyltransferase activity
HLB42_RS10765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLB42_RS10775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HLB42_RS10785	COG4106	trans-aconitate 2-methyltransferase activity
HLB42_RS10790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLB42_RS10800	COG1346	cytolysis
HLB42_RS10825	COG0616	signal peptide processing
HLB42_RS10840	COG2201	protein-glutamate methylesterase activity
HLB42_RS10845	COG3290	protein histidine kinase activity
HLB42_RS10870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB42_RS10875	COG0037	tRNA processing
HLB42_RS10890	COG1231	oxidoreductase activity
HLB42_RS10900	COG0354	folic acid binding
HLB42_RS10905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HLB42_RS10910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLB42_RS10910	COG1648	precorrin-2 dehydrogenase activity
HLB42_RS10940	COG0739	heme binding
HLB42_RS10950	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HLB42_RS10955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLB42_RS10960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLB42_RS10975	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HLB42_RS10975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HLB42_RS10990	COG2720	vancomycin resistance protein
HLB42_RS10995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLB42_RS11015	COG2096	Adenosyltransferase
HLB42_RS11020	COG0303	'Molybdopterin
HLB42_RS11030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HLB42_RS11035	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HLB42_RS11045	COG0730	response to heat
HLB42_RS11055	COG0346	lactoylglutathione lyase activity
HLB42_RS11065	COG2217	Heavy metal translocating P-type atpase
HLB42_RS11085	COG3424	synthase
HLB42_RS11090	COG0667	Aldo Keto reductase
HLB42_RS11095	COG0778	Nitroreductase
HLB42_RS11115	COG3361	conserved protein (COG2071)
HLB42_RS11125	COG2124	cytochrome p450
HLB42_RS11130	COG0456	acetyltransferase
HLB42_RS11145	COG1166	arginine decarboxylase activity
HLB42_RS11160	COG1408	metallophosphoesterase
HLB42_RS11165	COG0825	malonyl-CoA metabolic process
HLB42_RS11170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HLB42_RS11180	COG1324	tolerance protein
HLB42_RS11190	COG2199	diguanylate cyclase activity
HLB42_RS11200	COG0628	permease
HLB42_RS11225	COG1764	response to oxidative stress
HLB42_RS11240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HLB42_RS11245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLB42_RS11260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HLB42_RS11275	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HLB42_RS11280	COG0205	6-phosphofructokinase activity
HLB42_RS11300	COG1285	pathogenesis
HLB42_RS11310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HLB42_RS11315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLB42_RS11325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HLB42_RS11335	COG0538	isocitrate dehydrogenase activity
HLB42_RS11345	COG1175	transmembrane transport
HLB42_RS11350	COG0395	ABC-type sugar transport system, permease component
HLB42_RS11380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HLB42_RS11380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLB42_RS11385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLB42_RS11400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLB42_RS11415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLB42_RS11440	COG1012	belongs to the aldehyde dehydrogenase family
HLB42_RS11465	COG0159	tryptophan synthase activity
HLB42_RS11470	COG0133	tryptophan synthase activity
HLB42_RS11475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLB42_RS11480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLB42_RS11495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLB42_RS11510	COG1012	belongs to the aldehyde dehydrogenase family
HLB42_RS11520	COG0506	proline dehydrogenase activity
HLB42_RS11535	COG2354	Protein conserved in bacteria
HLB42_RS11545	COG1764	response to oxidative stress
HLB42_RS11570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLB42_RS11585	COG2203	Gaf domain
HLB42_RS11585	COG2199	diguanylate cyclase activity
HLB42_RS11590	COG4251	negative regulation of phosphorylation
HLB42_RS11605	COG1132	(ABC) transporter
HLB42_RS11625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLB42_RS11650	COG0252	asparaginase activity
HLB42_RS11655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HLB42_RS11660	COG0302	gtp cyclohydrolase
HLB42_RS11670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLB42_RS11675	COG0084	hydrolase, TatD family'
HLB42_RS11695	COG0039	L-malate dehydrogenase activity
HLB42_RS11705	COG0617	tRNA 3'-terminal CCA addition
HLB42_RS11725	COG1755	Isoprenylcysteine carboxyl methyltransferase
HLB42_RS11730	COG1703	isobutyryl-CoA mutase activity
HLB42_RS11735	COG0406	alpha-ribazole phosphatase activity
HLB42_RS11750	COG0138	bifunctional purine biosynthesis protein purh
HLB42_RS11760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HLB42_RS11770	COG0463	Glycosyl transferase, family 2
HLB42_RS11780	COG1408	metallophosphoesterase
HLB42_RS11800	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLB42_RS11825	COG2321	neutral zinc metallopeptidase
HLB42_RS11830	COG3842	ATPase activity
HLB42_RS11865	COG2823	Periplasmic or secreted lipoprotein
HLB42_RS11865	COG1652	LysM domain
HLB42_RS11880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB42_RS11885	COG2151	metal-sulfur cluster biosynthetic enzyme
HLB42_RS11890	COG2738	Putative neutral zinc metallopeptidase
HLB42_RS11895	COG2359	stage V sporulation protein S
HLB42_RS11910	COG0024	Methionine aminopeptidase
HLB42_RS11915	COG2362	D-Aminopeptidase
HLB42_RS11935	COG0123	including yeast histone deacetylase and acetoin utilization protein
HLB42_RS11955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB42_RS11960	COG2197	response regulator
HLB42_RS11965	COG0667	Aldo Keto reductase
HLB42_RS11985	COG2137	regulation of response to DNA damage stimulus
HLB42_RS11990	COG0268	Binds directly to 16S ribosomal RNA
HLB42_RS12000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB42_RS12010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HLB42_RS12015	COG1378	Sugar-specific transcriptional regulator TrmB
HLB42_RS12040	COG4974	Belongs to the 'phage' integrase family
HLB42_RS12050	COG4251	negative regulation of phosphorylation
HLB42_RS12055	COG4251	negative regulation of phosphorylation
HLB42_RS12065	COG0714	Associated with various cellular activities
HLB42_RS12095	COG0481	GTPase activity
HLB42_RS12120	COG0653	protein targeting
HLB42_RS12125	COG0259	pyridoxamine-phosphate oxidase activity
HLB42_RS12130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HLB42_RS12140	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HLB42_RS12145	COG0180	Tryptophanyl-tRNA synthetase
HLB42_RS12155	COG1063	alcohol dehydrogenase
HLB42_RS12170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLB42_RS12175	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS12180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLB42_RS12185	COG0805	protein transport
HLB42_RS12190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HLB42_RS12205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLB42_RS12215	COG4591	ABC-type transport system involved in lipoprotein release permease component
HLB42_RS12235	COG0275	rRNA processing
HLB42_RS12240	COG2001	Belongs to the MraZ family
HLB42_RS12245	COG2363	Small membrane protein
HLB42_RS12270	COG1999	signal sequence binding
HLB42_RS12275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLB42_RS12275	COG1845	cytochrome c oxidase, subunit III
HLB42_RS12280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HLB42_RS12280	COG1565	acr, cog1565
HLB42_RS12285	COG0109	protoheme IX farnesyltransferase activity
HLB42_RS12290	COG1612	heme a metabolic process
HLB42_RS12290	COG0109	protoheme IX farnesyltransferase activity
HLB42_RS12310	COG0215	cysteine-tRNA ligase activity
HLB42_RS12320	COG0765	amino acid transport
HLB42_RS12325	COG0789	Transcriptional regulator
HLB42_RS12335	COG1874	Beta-galactosidase
HLB42_RS12335	COG0366	Alpha amylase catalytic
HLB42_RS12345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLB42_RS12360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB42_RS12360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HLB42_RS12365	COG3938	Belongs to the proline racemase family
HLB42_RS12380	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HLB42_RS12390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLB42_RS12390	COG0574	Belongs to the PEP-utilizing enzyme family
HLB42_RS12405	COG0285	dihydrofolate synthase activity
HLB42_RS12410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLB42_RS12425	COG0277	FAD linked oxidase domain protein
HLB42_RS12440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLB42_RS12480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HLB42_RS12500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB42_RS12510	COG0659	secondary active sulfate transmembrane transporter activity
HLB42_RS12525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLB42_RS12545	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HLB42_RS12565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLB42_RS12650	COG3706	GGDEF domain
HLB42_RS12675	COG0423	glycine-tRNA ligase activity
HLB42_RS12690	COG0277	FAD linked oxidase domain protein
HLB42_RS12695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HLB42_RS12705	COG2154	pterin-4-alpha-carbinolamine dehydratase
HLB42_RS12725	COG0187	DNA topoisomerase II activity
HLB42_RS12730	COG0557	exoribonuclease II activity
HLB42_RS12735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLB42_RS12750	COG4585	Histidine kinase
HLB42_RS12750	COG2203	Gaf domain
HLB42_RS12760	COG2197	response regulator
HLB42_RS12780	COG0667	Aldo Keto reductase
HLB42_RS12785	COG0366	Alpha amylase catalytic
HLB42_RS12785	COG1470	cell adhesion involved in biofilm formation
HLB42_RS12795	COG0346	lactoylglutathione lyase activity
HLB42_RS12800	COG3706	GGDEF domain
HLB42_RS12805	COG0105	UTP biosynthetic process
HLB42_RS12825	COG0358	DNA primase activity
HLB42_RS12835	COG0372	Belongs to the citrate synthase family
HLB42_RS12870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB42_RS12880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLB42_RS12885	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HLB42_RS12900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLB42_RS12915	COG0719	Fe-S assembly protein
HLB42_RS12930	COG0719	Fe-S assembly protein
HLB42_RS12935	COG0396	ATPase activity
HLB42_RS12945	COG0848	biopolymer transport protein
HLB42_RS12960	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HLB42_RS12975	COG0583	DNA-binding transcription factor activity
HLB42_RS12980	COG0306	phosphate transporter
HLB42_RS12995	COG1874	Beta-galactosidase
HLB42_RS12995	COG0366	Alpha amylase catalytic
HLB42_RS13015	COG0489	protein tyrosine kinase activity
HLB42_RS13040	COG0642	Histidine kinase
HLB42_RS13055	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HLB42_RS13060	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HLB42_RS13065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLB42_RS13070	COG0569	domain protein
HLB42_RS13095	COG1428	Deoxynucleoside kinase
HLB42_RS13100	COG1428	Deoxynucleoside kinase
HLB42_RS13130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLB42_RS13150	COG0438	transferase activity, transferring glycosyl groups
HLB42_RS13165	COG0438	transferase activity, transferring glycosyl groups
HLB42_RS13205	COG2304	oxidoreductase activity
HLB42_RS13230	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HLB42_RS13230	COG0662	Cupin 2, conserved barrel domain protein
HLB42_RS13250	COG0315	cyclic pyranopterin monophosphate synthase activity
HLB42_RS13260	COG1396	sequence-specific DNA binding
HLB42_RS13270	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HLB42_RS13285	COG0166	Belongs to the GPI family
HLB42_RS13300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HLB42_RS13330	COG2205	protein histidine kinase activity
HLB42_RS13330	COG0784	Response regulator, receiver
HLB42_RS13330	COG2198	Histidine kinase
HLB42_RS13375	COG1595	DNA-templated transcription, initiation
HLB42_RS13380	COG1321	iron dependent repressor
HLB42_RS13410	COG0572	uridine kinase
HLB42_RS13415	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HLB42_RS13420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLB42_RS13425	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HLB42_RS13430	COG1674	ftsk spoiiie
HLB42_RS13435	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
HLB42_RS13445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HLB42_RS13450	COG0772	Belongs to the SEDS family
HLB42_RS13475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HLB42_RS13480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB42_RS13490	COG0438	transferase activity, transferring glycosyl groups
HLB42_RS13495	COG1358	cellular component organization or biogenesis
HLB42_RS13520	COG2304	oxidoreductase activity
HLB42_RS13540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HLB42_RS13560	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HLB42_RS13570	COG2224	Isocitrate lyase
HLB42_RS13580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HLB42_RS13590	COG0515	serine threonine protein kinase
HLB42_RS13590	COG2815	serine threonine protein kinase
HLB42_RS13595	COG0419	ATPase involved in DNA repair
HLB42_RS13600	COG0420	3'-5' exonuclease activity
HLB42_RS13610	COG0750	zinc metalloprotease
HLB42_RS13615	COG0439	Biotin carboxylase
HLB42_RS13620	COG0511	ligase activity, forming carbon-carbon bonds
HLB42_RS13630	COG1363	Peptidase, m42
HLB42_RS13635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB42_RS13640	COG1482	cell wall glycoprotein biosynthetic process
HLB42_RS13675	COG0070	glutamate synthase
HLB42_RS13675	COG0067	glutamate synthase
HLB42_RS13675	COG0069	glutamate synthase activity
HLB42_RS13690	COG2385	sporulation resulting in formation of a cellular spore
HLB42_RS13700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLB42_RS13730	COG3179	chitinase
HLB42_RS13950	COG0270	DNA (cytosine-5-)-methyltransferase activity
HLB42_RS13995	COG0606	chelatase, subunit chli
HLB42_RS14015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLB42_RS14020	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HLB42_RS14040	COG0515	serine threonine protein kinase
HLB42_RS14040	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLB42_RS14055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLB42_RS14070	COG0544	peptidyl-prolyl cis-trans isomerase activity
HLB42_RS14075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLB42_RS14080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLB42_RS14095	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS14100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLB42_RS14105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLB42_RS14110	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HLB42_RS14120	COG0789	Transcriptional regulator
HLB42_RS14125	COG0584	glycerophosphoryl diester phosphodiesterase
HLB42_RS14145	COG0395	ABC-type sugar transport system, permease component
HLB42_RS14150	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HLB42_RS14155	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HLB42_RS14160	COG0823	Involved in the tonB-independent uptake of proteins
HLB42_RS14160	COG1506	peptidase
HLB42_RS14160	COG4946	Tricorn protease homolog
HLB42_RS14165	COG1077	Cell shape determining protein MreB Mrl
HLB42_RS14170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HLB42_RS14180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLB42_RS14185	COG0726	polysaccharide deacetylase
HLB42_RS14200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HLB42_RS14210	COG0494	nUDIX hydrolase
HLB42_RS14215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HLB42_RS14220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLB42_RS14225	COG0789	Transcriptional regulator
HLB42_RS14230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLB42_RS14235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLB42_RS14240	COG0513	Belongs to the DEAD box helicase family
HLB42_RS14255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HLB42_RS14270	COG2897	thiosulfate sulfurtransferase activity
HLB42_RS14285	COG0708	Exodeoxyribonuclease III
HLB42_RS14290	COG3135	benzoate transporter
HLB42_RS14295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB42_RS14305	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HLB42_RS14310	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HLB42_RS14335	COG1653	transport
HLB42_RS14340	COG1175	transmembrane transport
HLB42_RS14345	COG0395	ABC-type sugar transport system, permease component
HLB42_RS14370	COG0217	transcriptional regulatory protein
HLB42_RS14385	COG0745	RESPONSE REGULATOR receiver
HLB42_RS14390	COG0784	Response regulator, receiver
HLB42_RS14390	COG3437	response regulator, receiver
HLB42_RS14410	COG0477	Major facilitator Superfamily
HLB42_RS14415	COG0772	Belongs to the SEDS family
HLB42_RS14430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HLB42_RS14435	COG2894	cell division
HLB42_RS14440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLB42_RS14450	COG2313	pseudouridylate synthase activity
HLB42_RS14455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLB42_RS14460	COG0745	RESPONSE REGULATOR receiver
HLB42_RS14465	COG2205	protein histidine kinase activity
HLB42_RS14470	COG0704	Plays a role in the regulation of phosphate uptake
HLB42_RS14480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLB42_RS14520	COG0494	nUDIX hydrolase
HLB42_RS14535	COG0463	Glycosyl transferase, family 2
HLB42_RS14560	COG2323	membrane
HLB42_RS14570	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLB42_RS14575	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HLB42_RS14580	COG1268	BioY protein
HLB42_RS14585	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HLB42_RS14585	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HLB42_RS14615	COG0135	phosphoribosylanthranilate isomerase activity
HLB42_RS14630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLB42_RS14640	COG0577	efflux transmembrane transporter activity
HLB42_RS14640	COG1136	(ABC) transporter
HLB42_RS14645	COG1136	(ABC) transporter
HLB42_RS14645	COG0577	efflux transmembrane transporter activity
HLB42_RS14655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLB42_RS14665	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLB42_RS14700	COG4895	conserved protein (DUF2196)
HLB42_RS14720	COG0567	Dehydrogenase, E1 component
HLB42_RS14725	COG0556	nucleotide-excision repair
HLB42_RS14730	COG0583	DNA-binding transcription factor activity
HLB42_RS14735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HLB42_RS14740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLB42_RS14755	COG0047	phosphoribosylformylglycinamidine synthase activity
HLB42_RS14765	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLB42_RS14770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HLB42_RS14790	COG0517	IMP dehydrogenase activity
HLB42_RS14790	COG0516	GMP reductase activity
HLB42_RS14795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HLB42_RS14805	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HLB42_RS14810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLB42_RS14820	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLB42_RS14825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HLB42_RS14830	COG0740	serine-type endopeptidase activity
HLB42_RS14840	COG4978	Transcriptional regulator
HLB42_RS14840	COG0789	Transcriptional regulator
HLB42_RS14845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLB42_RS14850	COG0745	RESPONSE REGULATOR receiver
HLB42_RS14855	COG4251	negative regulation of phosphorylation
HLB42_RS14860	COG0784	Response regulator, receiver
HLB42_RS14875	COG2095	MarC family integral membrane protein
HLB42_RS14895	COG0513	Belongs to the DEAD box helicase family
HLB42_RS14910	COG0372	Belongs to the citrate synthase family
HLB42_RS14915	COG0300	oxidoreductase activity
HLB42_RS14930	COG0039	L-malate dehydrogenase activity
HLB42_RS14960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB42_RS14970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLB42_RS14975	COG1970	mechanosensitive ion channel activity
HLB42_RS14980	COG2873	o-acetylhomoserine
HLB42_RS14990	COG0545	Peptidyl-prolyl cis-trans isomerase
HLB42_RS14995	COG0681	Belongs to the peptidase S26 family
HLB42_RS15005	COG0488	(ABC) transporter
HLB42_RS15010	COG5504	Zn-dependent protease
HLB42_RS15015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLB42_RS15020	COG1121	(ABC) transporter
HLB42_RS15050	COG0456	acetyltransferase
HLB42_RS15055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLB42_RS15060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HLB42_RS15065	COG0509	glycine decarboxylation via glycine cleavage system
HLB42_RS15070	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLB42_RS15070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLB42_RS15095	COG2340	Cysteine-rich secretory protein family
HLB42_RS15105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLB42_RS15115	COG0564	pseudouridine synthase activity
HLB42_RS15130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLB42_RS15135	COG1595	DNA-templated transcription, initiation
HLB42_RS15155	COG1174	glycine betaine transport
HLB42_RS15160	COG0517	IMP dehydrogenase activity
HLB42_RS15160	COG1125	glycine betaine transport
HLB42_RS15165	COG1174	glycine betaine transport
HLB42_RS15170	COG1732	Glycine betaine
HLB42_RS15190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLB42_RS15195	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HLB42_RS15205	COG1331	Highly conserved protein containing a thioredoxin domain
HLB42_RS15220	COG0583	DNA-binding transcription factor activity
HLB42_RS15260	COG0463	Glycosyl transferase, family 2
HLB42_RS15260	COG1216	Glycosyl transferase, family 2
HLB42_RS15265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB42_RS15270	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HLB42_RS15295	COG0438	transferase activity, transferring glycosyl groups
HLB42_RS15300	COG2244	polysaccharide biosynthetic process
HLB42_RS15330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLB42_RS15340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLB42_RS15345	COG2856	Zn peptidase
HLB42_RS15365	COG0515	serine threonine protein kinase
HLB42_RS15365	COG2815	serine threonine protein kinase
HLB42_RS15375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLB42_RS15395	COG2309	aminopeptidase activity
HLB42_RS15400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HLB42_RS15405	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HLB42_RS15425	COG2860	membrane
HLB42_RS15440	COG0861	Integral membrane protein TerC family
HLB42_RS15460	COG2177	Part of the ABC transporter FtsEX involved in
HLB42_RS15465	COG2884	Cell division ATP-binding protein ftsE
HLB42_RS15470	COG0793	Belongs to the peptidase S41A family
HLB42_RS15475	COG0360	Binds together with S18 to 16S ribosomal RNA
HLB42_RS15480	COG0629	single-stranded DNA binding
HLB42_RS15485	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HLB42_RS15490	COG0359	binds to the 23S rRNA
HLB42_RS15500	COG1506	peptidase
HLB42_RS15505	COG1418	mRNA catabolic process
HLB42_RS15550	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HLB42_RS15555	COG4106	trans-aconitate 2-methyltransferase activity
HLB42_RS15575	COG4251	negative regulation of phosphorylation
HLB42_RS15580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HLB42_RS15590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HLB42_RS15595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HLB42_RS15610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLB42_RS15625	COG1160	GTP binding
HLB42_RS15630	COG5001	Diguanylate cyclase
HLB42_RS15630	COG3300	MHYT domain
HLB42_RS15640	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HLB42_RS15655	COG0706	membrane insertase activity
HLB42_RS15660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HLB42_RS15670	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HLB42_RS15680	COG3960	tartronate-semialdehyde synthase activity
HLB42_RS15685	COG3622	Belongs to the hyi family
HLB42_RS15690	COG2084	Dehydrogenase
HLB42_RS15700	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HLB42_RS15705	COG2720	vancomycin resistance protein
HLB42_RS15715	COG4948	Mandelate Racemase Muconate Lactonizing
HLB42_RS15725	COG1404	Belongs to the peptidase S8 family
HLB42_RS15740	COG0123	including yeast histone deacetylase and acetoin utilization protein
HLB42_RS15750	COG0598	Magnesium transport protein CorA
HLB42_RS15755	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HLB42_RS15760	COG1570	exodeoxyribonuclease VII activity
HLB42_RS15785	COG0165	Argininosuccinate lyase
HLB42_RS15795	COG0137	argininosuccinate synthase activity
HLB42_RS15800	COG2204	response regulator
HLB42_RS15805	COG1607	acyl-coa hydrolase
HLB42_RS15820	COG4214	carbohydrate transport
HLB42_RS15840	COG0180	Tryptophanyl-tRNA synthetase
HLB42_RS15850	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HLB42_RS15875	COG0799	negative regulation of ribosome biogenesis
HLB42_RS15895	COG0742	ribosomal rna small subunit methyltransferase
HLB42_RS15900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HLB42_RS15910	COG2890	protein-(glutamine-N5) methyltransferase activity
HLB42_RS15915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLB42_RS15935	COG0492	ferredoxin-NADP+ reductase activity
HLB42_RS15950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLB42_RS15960	COG1111	helicase
HLB42_RS15960	COG1205	dead DEAH box helicase
HLB42_RS15965	COG0436	Aminotransferase
HLB42_RS15975	COG0083	homoserine kinase activity
HLB42_RS15995	COG2050	protein possibly involved in aromatic compounds catabolism
HLB42_RS16000	COG1233	COG1233 Phytoene dehydrogenase and related
HLB42_RS16015	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLB42_RS16025	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS16045	COG2326	polyphosphate kinase activity
HLB42_RS16065	COG1012	belongs to the aldehyde dehydrogenase family
HLB42_RS16090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HLB42_RS16095	COG0085	RNA polymerase activity
HLB42_RS16100	COG1960	acyl-CoA dehydrogenase activity
HLB42_RS16110	COG0601	transmembrane transport
HLB42_RS16125	COG4221	oxidoreductase activity
HLB42_RS16135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLB42_RS16140	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS16160	COG4608	Belongs to the ABC transporter superfamily
HLB42_RS16175	COG0601	transmembrane transport
HLB42_RS16180	COG0747	negative chemotaxis
HLB42_RS16185	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLB42_RS16190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HLB42_RS16200	COG3206	protein involved in exopolysaccharide biosynthesis
HLB42_RS16205	COG1024	Enoyl-CoA hydratase
HLB42_RS16220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLB42_RS16235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HLB42_RS16240	COG0460	homoserine dehydrogenase
HLB42_RS16250	COG0802	atpase or kinase
HLB42_RS16315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLB42_RS16320	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLB42_RS16325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLB42_RS16330	COG0640	Transcriptional regulator
HLB42_RS16335	COG1937	Protein conserved in bacteria
HLB42_RS16340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB42_RS16340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB42_RS16490	COG4133	protoheme IX ABC transporter activity
HLB42_RS16515	COG0857	belongs to the CobB CobQ family
HLB42_RS16515	COG0280	phosphate acetyltransferase
HLB42_RS16520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLB42_RS16530	COG1090	epimerase
HLB42_RS16535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLB42_RS16550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HLB42_RS16555	COG1414	Transcriptional regulator
HLB42_RS16570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLB42_RS16580	COG0281	malic enzyme
HLB42_RS16585	COG1511	domain protein
HLB42_RS16595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLB42_RS16605	COG1960	acyl-CoA dehydrogenase activity
HLB42_RS16610	COG3437	response regulator, receiver
HLB42_RS16630	COG0584	glycerophosphoryl diester phosphodiesterase
HLB42_RS16635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HLB42_RS16640	COG0432	Pfam Uncharacterised protein family UPF0047
HLB42_RS16645	COG1454	alcohol dehydrogenase
HLB42_RS16650	COG0792	nuclease activity
HLB42_RS16655	COG0546	phosphoglycolate phosphatase activity
HLB42_RS16660	COG0571	ribonuclease III activity
HLB42_RS16695	COG4946	Tricorn protease homolog
HLB42_RS16695	COG0823	Involved in the tonB-independent uptake of proteins
HLB42_RS16695	COG1506	peptidase
HLB42_RS16705	COG0114	fumarate hydratase activity
HLB42_RS16720	COG0156	8-amino-7-oxononanoate synthase activity
HLB42_RS16730	COG2226	methyltransferase
HLB42_RS16740	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLB42_RS16745	COG2233	PERMEase
HLB42_RS16760	COG1438	arginine binding
HLB42_RS16765	COG2814	Major facilitator Superfamily
HLB42_RS16790	COG0492	ferredoxin-NADP+ reductase activity
HLB42_RS16795	COG2720	vancomycin resistance protein
HLB42_RS16800	COG1475	DNA binding
HLB42_RS16805	COG1192	Involved in chromosome partitioning
HLB42_RS16810	COG0357	Ribosomal RNA small subunit methyltransferase G
HLB42_RS16820	COG0445	tRNA wobble uridine modification
HLB42_RS16830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLB42_RS16835	COG0022	dehydrogenase e1 component
HLB42_RS16855	COG0745	RESPONSE REGULATOR receiver
HLB42_RS16890	COG0601	transmembrane transport
HLB42_RS16915	COG1609	Transcriptional regulator
HLB42_RS16925	COG1175	transmembrane transport
HLB42_RS16930	COG0395	ABC-type sugar transport system, permease component
HLB42_RS16985	COG2211	Major facilitator Superfamily
HLB42_RS17065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB42_RS17080	COG1470	cell adhesion involved in biofilm formation
HLB42_RS17080	COG0366	Alpha amylase catalytic
HLB42_RS17085	COG1846	Transcriptional regulator
HLB42_RS17095	COG2514	catechol 2,3-dioxygenase activity
HLB42_RS17100	COG0400	carboxylic ester hydrolase activity
HLB42_RS17105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLB42_RS17135	COG0655	NAD(P)H dehydrogenase (quinone) activity
HLB42_RS17145	COG0346	lactoylglutathione lyase activity
HLB42_RS17155	COG1454	alcohol dehydrogenase
HLB42_RS17160	COG4187	Peptidase family M20/M25/M40
HLB42_RS17165	COG0346	lactoylglutathione lyase activity
HLB42_RS17195	COG2217	Heavy metal translocating P-type atpase
HLB42_RS17220	COG0745	RESPONSE REGULATOR receiver
HLB42_RS17240	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS17260	COG4251	negative regulation of phosphorylation
HLB42_RS17290	COG0412	Dienelactone hydrolase
HLB42_RS17300	COG1396	sequence-specific DNA binding
HLB42_RS17310	COG2205	protein histidine kinase activity
HLB42_RS17335	COG4585	Histidine kinase
HLB42_RS17340	COG2197	response regulator
HLB42_RS17375	COG2197	response regulator
HLB42_RS17425	COG3706	GGDEF domain
HLB42_RS17445	COG4566	intracellular signal transduction
HLB42_RS17450	COG4191	Histidine kinase
HLB42_RS17465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLB42_RS17470	COG3706	GGDEF domain
HLB42_RS17510	COG4251	negative regulation of phosphorylation
HLB42_RS17515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLB42_RS17525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLB42_RS17550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLB42_RS17575	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HLB42_RS17610	COG0747	negative chemotaxis
HLB42_RS17615	COG0747	negative chemotaxis
HLB42_RS17625	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS17660	COG2313	pseudouridylate synthase activity
HLB42_RS17665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLB42_RS17670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLB42_RS17680	COG0573	inorganic phosphate transmembrane transporter activity
HLB42_RS17685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLB42_RS17690	COG2205	protein histidine kinase activity
HLB42_RS17695	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HLB42_RS17705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HLB42_RS17715	COG2205	protein histidine kinase activity
HLB42_RS17720	COG2197	response regulator
HLB42_RS17775	COG2801	Transposase and inactivated derivatives
HLB42_RS17825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB42_RS17825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLB42_RS17840	COG1120	ATPase activity
HLB42_RS17845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB42_RS17850	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HLB42_RS17855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB42_RS17880	COG3546	catalase activity
HLB42_RS17890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB42_RS17895	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HLB42_RS17905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB42_RS17910	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HLB42_RS17925	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HLB42_RS17930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLB42_RS17945	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HLB42_RS17975	COG2199	diguanylate cyclase activity
HLB42_RS17975	COG2200	EAL domain
HLB42_RS18095	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HLB42_RS18125	COG1253	flavin adenine dinucleotide binding
HLB42_RS18180	COG1595	DNA-templated transcription, initiation
HLB42_RS18300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLB42_RS18330	COG1192	Involved in chromosome partitioning
HLB42_RS18335	COG1475	DNA binding
HLB42_RS18400	COG3263	regulation of cellular component size
HLB42_RS18465	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HLB42_RS18470	COG4804	nuclease activity
HLB42_RS18505	COG2801	Transposase and inactivated derivatives
HLB42_RS18530	COG2010	Cytochrome c
HLB42_RS18560	COG1309	transcriptional regulator
HLB42_RS18600	COG0640	Transcriptional regulator
HLB42_RS18605	COG1073	alpha beta
HLB42_RS18635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLB42_RS18645	COG0402	S-adenosylhomocysteine deaminase activity
HLB42_RS18650	COG2252	PERMEase
HLB42_RS18655	COG0318	PFAM AMP-dependent synthetase and ligase
HLB42_RS18660	COG0776	regulation of translation
HLB42_RS18665	COG2239	Acts as a magnesium transporter
HLB42_RS18675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLB42_RS18680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB42_RS18685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB42_RS18690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB42_RS18710	COG0493	'glutamate synthase
HLB42_RS18715	COG0730	response to heat
HLB42_RS18720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB42_RS18730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB42_RS18730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB42_RS18735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB42_RS18740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB42_RS18745	COG1937	Protein conserved in bacteria
HLB42_RS18765	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HLB42_RS18775	COG2084	Dehydrogenase
HLB42_RS18780	COG2199	diguanylate cyclase activity
HLB42_RS18780	COG2203	Gaf domain
HLB42_RS18790	COG2124	cytochrome p450
HLB42_RS18795	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS18800	COG0517	IMP dehydrogenase activity
HLB42_RS18850	COG2132	Multicopper oxidase
HLB42_RS18895	COG1309	transcriptional regulator
HLB42_RS18925	COG0601	transmembrane transport
HLB42_RS18930	COG0747	negative chemotaxis
HLB42_RS18980	COG0183	Belongs to the thiolase family
HLB42_RS18985	COG0318	PFAM AMP-dependent synthetase and ligase
HLB42_RS18995	COG1960	acyl-CoA dehydrogenase activity
HLB42_RS19000	COG1802	Transcriptional regulator
HLB42_RS19025	COG1505	serine-type exopeptidase activity
HLB42_RS19045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HLB42_RS19055	COG1132	(ABC) transporter
HLB42_RS19060	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HLB42_RS19065	COG4251	negative regulation of phosphorylation
HLB42_RS19085	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HLB42_RS19090	COG2226	methyltransferase
HLB42_RS19095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB42_RS19100	COG0601	transmembrane transport
HLB42_RS19105	COG0747	negative chemotaxis
HLB42_RS19110	COG0747	negative chemotaxis
HLB42_RS19115	COG2188	Transcriptional regulator
HLB42_RS19120	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HLB42_RS19125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLB42_RS19135	COG0745	RESPONSE REGULATOR receiver
HLB42_RS19155	COG0840	transmembrane signaling receptor activity
HLB42_RS19155	COG2203	Gaf domain
HLB42_RS19185	COG1960	acyl-CoA dehydrogenase activity
HLB42_RS19200	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS19215	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HLB42_RS19240	COG0673	inositol 2-dehydrogenase activity
HLB42_RS19250	COG1960	acyl-CoA dehydrogenase activity
HLB42_RS19260	COG1764	response to oxidative stress
HLB42_RS19285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB42_RS19290	COG0601	transmembrane transport
HLB42_RS19300	COG0006	proline dipeptidase activity
HLB42_RS19305	COG0024	Methionine aminopeptidase
HLB42_RS19310	COG0006	proline dipeptidase activity
HLB42_RS19320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB42_RS19320	COG2022	thiamine diphosphate biosynthetic process
HLB42_RS19335	COG2801	Transposase and inactivated derivatives
HLB42_RS19350	COG1175	transmembrane transport
HLB42_RS19355	COG0395	ABC-type sugar transport system, permease component
HLB42_RS19365	COG2027	D-alanyl-D-alanine carboxypeptidase
HLB42_RS19370	COG2366	antibiotic biosynthetic process
HLB42_RS19385	COG1845	cytochrome c oxidase, subunit III
HLB42_RS19410	COG0028	Belongs to the TPP enzyme family
HLB42_RS19415	COG4948	Mandelate Racemase Muconate Lactonizing
HLB42_RS19420	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS19445	COG3387	PFAM Glycoside hydrolase 15-related
HLB42_RS19480	COG1695	Transcriptional regulator
HLB42_RS19485	COG1309	transcriptional regulator
HLB42_RS19525	COG2072	flavoprotein involved in K transport
HLB42_RS19535	COG4251	negative regulation of phosphorylation
HLB42_RS19545	COG3835	regulator
HLB42_RS19555	COG1012	belongs to the aldehyde dehydrogenase family
HLB42_RS19560	COG2368	4-hydroxyphenylacetate
HLB42_RS19570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HLB42_RS19575	COG3971	2-oxopent-4-enoate hydratase activity
HLB42_RS19595	COG1192	Involved in chromosome partitioning
HLB42_RS19605	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS19610	COG1063	alcohol dehydrogenase
HLB42_RS19620	COG1072	(Pantothenic acid kinase))
HLB42_RS19630	COG1175	transmembrane transport
HLB42_RS19640	COG1609	Transcriptional regulator
HLB42_RS19650	COG2304	oxidoreductase activity
HLB42_RS19655	COG3387	PFAM Glycoside hydrolase 15-related
HLB42_RS19660	COG0577	efflux transmembrane transporter activity
HLB42_RS19660	COG1136	(ABC) transporter
HLB42_RS19685	COG3424	synthase
HLB42_RS19695	COG0411	ABC transporter
HLB42_RS19715	COG1028	Short-chain dehydrogenase reductase Sdr
HLB42_RS19715	COG0604	alcohol dehydrogenase
HLB42_RS19715	COG3321	synthase
HLB42_RS19720	COG1960	acyl-CoA dehydrogenase activity
HLB42_RS19735	COG3706	GGDEF domain
HLB42_RS19740	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HLB42_RS19740	COG2199	diguanylate cyclase activity
HLB42_RS19750	COG1940	carbohydrate kinase activity
HLB42_RS19750	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HLB42_RS19755	COG3844	kynureninase activity
HLB42_RS19760	COG3483	tryptophan 2,3-dioxygenase activity
HLB42_RS19785	COG0243	molybdopterin cofactor binding
HLB42_RS19830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLB42_RS19840	COG0673	inositol 2-dehydrogenase activity
HLB42_RS19845	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLB42_RS19850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB42_RS19855	COG0601	transmembrane transport
HLB42_RS19870	COG1414	Transcriptional regulator
HLB42_RS19875	COG0006	proline dipeptidase activity
HLB42_RS19880	COG1070	Carbohydrate kinase
HLB42_RS19890	COG1129	ABC transporter
HLB42_RS19895	COG4214	carbohydrate transport
HLB42_RS19900	COG4213	ABC transporter substrate-binding protein
HLB42_RS19910	COG0673	inositol 2-dehydrogenase activity
HLB42_RS19915	COG1082	Xylose isomerase domain protein TIM barrel
HLB42_RS19920	COG1879	ABC-type sugar transport system periplasmic component
HLB42_RS19925	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB42_RS19930	COG1129	ABC transporter
HLB42_RS19950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLB42_RS19970	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HLB42_RS19980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB42_RS19990	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HLB42_RS19995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HLB42_RS20000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HLB42_RS20005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLB42_RS20010	COG2390	Transcriptional regulator
HLB42_RS20015	COG2373	Large extracellular alpha-helical protein
HLB42_RS20025	COG1063	alcohol dehydrogenase
HLB42_RS20035	COG1073	alpha beta
HLB42_RS20235	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLB42_RS20255	COG1695	Transcriptional regulator
HLB42_RS20265	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HLB42_RS20310	COG2197	response regulator
HLB42_RS20315	COG4585	Histidine kinase
HLB42_RS20355	COG0793	Belongs to the peptidase S41A family
HLB42_RS20365	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLB42_RS20375	COG2184	nucleotidyltransferase activity
HLB42_RS20390	COG1695	Transcriptional regulator
HLB42_RS20555	COG4533	DNA binding
HLB42_RS20575	COG1192	Involved in chromosome partitioning
HLB42_RS20615	COG1475	DNA binding
HLB42_RS20770	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HLB42_RS20830	COG4555	ABC transporter
HLB42_RS20840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLB42_RS20850	COG2354	Protein conserved in bacteria
HLB42_RS20855	COG1285	pathogenesis
HLB42_RS20880	COG2217	Heavy metal translocating P-type atpase
HLB42_RS20910	COG1196	nuclear chromosome segregation
HLB42_RS20910	COG0741	lytic transglycosylase activity
HLB42_RS20910	COG0739	heme binding
HLB42_RS20920	COG2217	Heavy metal translocating P-type atpase
HLB42_RS20940	COG2217	Heavy metal translocating P-type atpase
HLB42_RS20960	COG0745	RESPONSE REGULATOR receiver
HLB42_RS20970	COG5002	protein histidine kinase activity
HLB42_RS20975	COG0745	RESPONSE REGULATOR receiver
HLB42_RS20980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB42_RS21000	COG2226	methyltransferase
HLB42_RS21025	COG2217	Heavy metal translocating P-type atpase
HLB42_RS21055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HLB42_RS21095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB42_RS21100	COG3088	subunit of a heme lyase
HLB42_RS21115	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLB42_RS21125	COG2217	Heavy metal translocating P-type atpase
HLB42_RS21140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HLB42_RS21160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLB42_RS21165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HLB42_RS21170	COG4942	peptidase
HLB42_RS21200	COG0640	Transcriptional regulator
HLB42_RS21220	COG1321	iron dependent repressor
HLB42_RS21225	COG1914	H( )-stimulated, divalent metal cation uptake system
HLB42_RS21320	COG0489	protein tyrosine kinase activity
HLB42_RS21360	COG4974	Belongs to the 'phage' integrase family
HLB42_RS21415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLB42_RS21455	COG3179	chitinase
HLB42_RS21675	COG0270	DNA (cytosine-5-)-methyltransferase activity
HLB42_RS21725	COG4969	Belongs to the N-Me-Phe pilin family
HLB42_RS21760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLB42_RS21775	COG1192	Involved in chromosome partitioning
HLB42_RS21925	COG1215	transferase activity, transferring glycosyl groups