locus-tag	class	description
EHF33_RS00010	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EHF33_RS00020	COG0667	Aldo Keto reductase
EHF33_RS00030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EHF33_RS00040	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EHF33_RS00045	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EHF33_RS00050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHF33_RS00060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EHF33_RS00065	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EHF33_RS00080	COG0670	Belongs to the BI1 family
EHF33_RS00090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EHF33_RS00095	COG2264	protein methyltransferase activity
EHF33_RS00100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EHF33_RS00120	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EHF33_RS00170	COG1482	cell wall glycoprotein biosynthetic process
EHF33_RS00185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EHF33_RS00190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EHF33_RS00205	COG0047	phosphoribosylformylglycinamidine synthase activity
EHF33_RS00215	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EHF33_RS00220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EHF33_RS00225	COG1054	Belongs to the UPF0176 family
EHF33_RS00235	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EHF33_RS00240	COG2832	Protein of unknown function (DUF454)
EHF33_RS00265	COG1185	polyribonucleotide nucleotidyltransferase activity
EHF33_RS00275	COG0538	isocitrate dehydrogenase activity
EHF33_RS00280	COG0456	acetyltransferase
EHF33_RS00285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EHF33_RS00290	COG0784	Response regulator, receiver
EHF33_RS00300	COG0628	permease
EHF33_RS00305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EHF33_RS00310	COG0393	Putative heavy-metal-binding
EHF33_RS00325	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
EHF33_RS00335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHF33_RS00345	COG2329	Antibiotic biosynthesis monooxygenase
EHF33_RS00365	COG1794	racemase activity, acting on amino acids and derivatives
EHF33_RS00375	COG0019	diaminopimelate decarboxylase activity
EHF33_RS00380	COG0482	sulfurtransferase activity
EHF33_RS00385	COG0552	protein localization to endoplasmic reticulum
EHF33_RS00405	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EHF33_RS00415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EHF33_RS00420	COG0339	signal peptide processing
EHF33_RS00425	COG2205	protein histidine kinase activity
EHF33_RS00425	COG2202	Pas domain
EHF33_RS00430	COG4895	conserved protein (DUF2196)
EHF33_RS00465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EHF33_RS00470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EHF33_RS00475	COG0805	protein transport
EHF33_RS00480	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EHF33_RS00480	COG1605	Chorismate mutase
EHF33_RS00490	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EHF33_RS00495	COG0196	riboflavin kinase activity
EHF33_RS00500	COG0494	nUDIX hydrolase
EHF33_RS00505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EHF33_RS00510	COG1388	LysM domain
EHF33_RS00510	COG3942	CHAP domain
EHF33_RS00520	COG0813	purine-nucleoside phosphorylase activity
EHF33_RS00525	COG1012	belongs to the aldehyde dehydrogenase family
EHF33_RS00535	COG0506	proline dehydrogenase activity
EHF33_RS00545	COG1846	Transcriptional regulator
EHF33_RS00550	COG2514	catechol 2,3-dioxygenase activity
EHF33_RS00560	COG1381	Involved in DNA repair and RecF pathway recombination
EHF33_RS00570	COG1435	thymidine kinase activity
EHF33_RS00575	COG0254	rRNA binding
EHF33_RS00580	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EHF33_RS00585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EHF33_RS00590	COG2199	diguanylate cyclase activity
EHF33_RS00605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EHF33_RS00610	COG0564	pseudouridine synthase activity
EHF33_RS00620	COG0454	-acetyltransferase
EHF33_RS00620	COG0456	acetyltransferase
EHF33_RS00635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EHF33_RS00645	COG0045	succinate-CoA ligase (ADP-forming) activity
EHF33_RS00655	COG0489	protein tyrosine kinase activity
EHF33_RS00685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHF33_RS00700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EHF33_RS00705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHF33_RS00710	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EHF33_RS00720	COG0561	phosphatase activity
EHF33_RS00750	COG2337	Toxic component of a toxin-antitoxin (TA) module
EHF33_RS00760	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EHF33_RS00780	COG1597	lipid kinase activity
EHF33_RS00790	COG0287	Prephenate dehydrogenase
EHF33_RS00805	COG0033	Phosphoglucomutase
EHF33_RS00820	COG0484	heat shock protein binding
EHF33_RS00830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EHF33_RS00845	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EHF33_RS00860	COG2154	pterin-4-alpha-carbinolamine dehydratase
EHF33_RS00865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHF33_RS00880	COG0789	Transcriptional regulator
EHF33_RS00885	COG1674	ftsk spoiiie
EHF33_RS00890	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
EHF33_RS00895	COG0791	NLP P60 protein
EHF33_RS00905	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EHF33_RS00915	COG0066	3-isopropylmalate dehydratase activity
EHF33_RS00920	COG0473	3-isopropylmalate dehydrogenase activity
EHF33_RS00940	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS00945	COG2873	o-acetylhomoserine
EHF33_RS00970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EHF33_RS00985	COG0305	Participates in initiation and elongation during chromosome replication
EHF33_RS00995	COG2188	Transcriptional regulator
EHF33_RS01000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EHF33_RS01005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHF33_RS01010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EHF33_RS01020	COG2094	Belongs to the DNA glycosylase MPG family
EHF33_RS01040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHF33_RS01055	COG4143	(ABC) transporter
EHF33_RS01060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHF33_RS01065	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHF33_RS01070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHF33_RS01075	COG0649	NAD binding
EHF33_RS01085	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EHF33_RS01090	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EHF33_RS01095	COG1034	ATP synthesis coupled electron transport
EHF33_RS01100	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EHF33_RS01105	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHF33_RS01110	COG0839	Belongs to the complex I subunit 6 family
EHF33_RS01115	COG0713	ATP synthesis coupled electron transport
EHF33_RS01120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EHF33_RS01125	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHF33_RS01130	COG1007	ATP synthesis coupled electron transport
EHF33_RS01160	COG0137	argininosuccinate synthase activity
EHF33_RS01175	COG0165	Argininosuccinate lyase
EHF33_RS01205	COG0505	Belongs to the CarA family
EHF33_RS01235	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EHF33_RS01240	COG2322	membrane
EHF33_RS01245	COG1612	heme a metabolic process
EHF33_RS01245	COG0109	protoheme IX farnesyltransferase activity
EHF33_RS01250	COG0109	protoheme IX farnesyltransferase activity
EHF33_RS01260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHF33_RS01260	COG1845	cytochrome c oxidase, subunit III
EHF33_RS01285	COG0590	tRNA wobble adenosine to inosine editing
EHF33_RS01290	COG0590	tRNA wobble adenosine to inosine editing
EHF33_RS01295	COG2199	diguanylate cyclase activity
EHF33_RS01300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EHF33_RS01305	COG0459	protein refolding
EHF33_RS01310	COG0667	Aldo Keto reductase
EHF33_RS01320	COG2318	DinB family
EHF33_RS01340	COG2894	cell division
EHF33_RS01345	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EHF33_RS01355	COG0667	Aldo Keto reductase
EHF33_RS01370	COG1131	(ABC) transporter
EHF33_RS01380	COG1166	arginine decarboxylase activity
EHF33_RS01400	COG1408	metallophosphoesterase
EHF33_RS01410	COG1461	Dihydroxyacetone kinase
EHF33_RS01430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EHF33_RS01435	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EHF33_RS01440	COG2124	cytochrome p450
EHF33_RS01445	COG0612	Peptidase, M16
EHF33_RS01455	COG0525	valine-tRNA ligase activity
EHF33_RS01475	COG1999	signal sequence binding
EHF33_RS01480	COG1609	Transcriptional regulator
EHF33_RS01490	COG2720	vancomycin resistance protein
EHF33_RS01495	COG1136	(ABC) transporter
EHF33_RS01505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EHF33_RS01520	COG0460	homoserine dehydrogenase
EHF33_RS01525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EHF33_RS01530	COG0494	nUDIX hydrolase
EHF33_RS01565	COG0747	negative chemotaxis
EHF33_RS01570	COG0142	geranyltranstransferase activity
EHF33_RS01575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EHF33_RS01580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EHF33_RS01605	COG0280	phosphate acetyltransferase
EHF33_RS01605	COG0857	belongs to the CobB CobQ family
EHF33_RS01635	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EHF33_RS01640	COG0511	ligase activity, forming carbon-carbon bonds
EHF33_RS01645	COG0439	Biotin carboxylase
EHF33_RS01665	COG0247	lactate metabolic process
EHF33_RS01665	COG2181	nitrate reductase activity
EHF33_RS01670	COG1959	2 iron, 2 sulfur cluster binding
EHF33_RS01675	COG0167	dihydroorotate dehydrogenase activity
EHF33_RS01690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EHF33_RS01705	COG1595	DNA-templated transcription, initiation
EHF33_RS01715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EHF33_RS01735	COG0237	dephospho-CoA kinase activity
EHF33_RS01740	COG0583	DNA-binding transcription factor activity
EHF33_RS01770	COG2304	oxidoreductase activity
EHF33_RS01780	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EHF33_RS01800	COG1131	(ABC) transporter
EHF33_RS01815	COG2346	COG2346, Truncated hemoglobins
EHF33_RS01820	COG0402	S-adenosylhomocysteine deaminase activity
EHF33_RS01850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EHF33_RS01865	COG2176	DNA-directed DNA polymerase activity
EHF33_RS01870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EHF33_RS01880	COG1111	helicase
EHF33_RS01880	COG1205	dead DEAH box helicase
EHF33_RS01895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHF33_RS01905	COG0446	pyridine nucleotide-disulphide oxidoreductase
EHF33_RS01910	COG3265	gluconokinase activity
EHF33_RS01920	COG4294	response to UV
EHF33_RS01930	COG0534	Mate efflux family protein
EHF33_RS01935	COG0072	phenylalanine-tRNA ligase activity
EHF33_RS01935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHF33_RS01945	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EHF33_RS01950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHF33_RS01955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHF33_RS01960	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EHF33_RS01975	COG0697	spore germination
EHF33_RS02000	COG0306	phosphate transporter
EHF33_RS02010	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHF33_RS02020	COG0583	DNA-binding transcription factor activity
EHF33_RS02025	COG0793	Belongs to the peptidase S41A family
EHF33_RS02040	COG0252	asparaginase activity
EHF33_RS02065	COG0028	Belongs to the TPP enzyme family
EHF33_RS02075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EHF33_RS02090	COG0222	ribosome binding
EHF33_RS02095	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EHF33_RS02100	COG0081	regulation of translation
EHF33_RS02105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EHF33_RS02110	COG0250	Participates in transcription elongation, termination and antitermination
EHF33_RS02115	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EHF33_RS02120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EHF33_RS02130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EHF33_RS02155	COG1132	(ABC) transporter
EHF33_RS02160	COG1132	(ABC) transporter
EHF33_RS02180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EHF33_RS02185	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EHF33_RS02195	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EHF33_RS02210	COG3878	Protein conserved in bacteria
EHF33_RS02215	COG0495	leucyl-tRNA aminoacylation
EHF33_RS02220	COG1494	fructose-1,6-bisphosphatase
EHF33_RS02250	COG2267	carboxylic ester hydrolase activity
EHF33_RS02260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EHF33_RS02265	COG2427	Protein of unknown function (DUF1641)
EHF33_RS02270	COG3383	formate dehydrogenase (NAD+) activity
EHF33_RS02275	COG4988	ABC transporter
EHF33_RS02280	COG1132	(ABC) transporter
EHF33_RS02285	COG1271	oxidase subunit
EHF33_RS02290	COG1294	oxidase, subunit
EHF33_RS02305	COG0180	Tryptophanyl-tRNA synthetase
EHF33_RS02325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EHF33_RS02335	COG2045	Belongs to the ComB family
EHF33_RS02340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EHF33_RS02365	COG1051	belongs to the nudix hydrolase family
EHF33_RS02370	COG1881	PFAM PEBP family protein
EHF33_RS02375	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EHF33_RS02375	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EHF33_RS02385	COG1121	(ABC) transporter
EHF33_RS02400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EHF33_RS02430	COG1454	alcohol dehydrogenase
EHF33_RS02475	COG0481	GTPase activity
EHF33_RS02485	COG2197	response regulator
EHF33_RS02505	COG0243	molybdopterin cofactor binding
EHF33_RS02510	COG0083	homoserine kinase activity
EHF33_RS02515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EHF33_RS02525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EHF33_RS02530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EHF33_RS02535	COG1854	S-ribosylhomocysteine lyase activity
EHF33_RS02560	COG1012	belongs to the aldehyde dehydrogenase family
EHF33_RS02570	COG0142	geranyltranstransferase activity
EHF33_RS02575	COG0300	oxidoreductase activity
EHF33_RS02580	COG0537	adenosine 5'-monophosphoramidase activity
EHF33_RS02585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EHF33_RS02595	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EHF33_RS02600	COG0515	serine threonine protein kinase
EHF33_RS02600	COG2815	serine threonine protein kinase
EHF33_RS02605	COG1104	cysteine desulfurase activity
EHF33_RS02615	COG1132	(ABC) transporter
EHF33_RS02640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EHF33_RS02655	COG1196	nuclear chromosome segregation
EHF33_RS02670	COG0791	NLP P60 protein
EHF33_RS02695	COG0017	Asparaginyl-tRNA synthetase
EHF33_RS02705	COG1914	H( )-stimulated, divalent metal cation uptake system
EHF33_RS02710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EHF33_RS02715	COG0006	proline dipeptidase activity
EHF33_RS02720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EHF33_RS02725	COG0124	histidyl-tRNA synthetase
EHF33_RS02740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EHF33_RS02745	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EHF33_RS02760	COG0126	phosphoglycerate kinase activity
EHF33_RS02775	COG0149	triose-phosphate isomerase activity
EHF33_RS02785	COG4712	double-strand break repair protein
EHF33_RS02790	COG0159	tryptophan synthase activity
EHF33_RS02795	COG0133	tryptophan synthase activity
EHF33_RS02800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHF33_RS02805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EHF33_RS02815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EHF33_RS02830	COG0322	excinuclease ABC activity
EHF33_RS02840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EHF33_RS02840	COG1017	nitric oxide dioxygenase activity
EHF33_RS02850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EHF33_RS02855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EHF33_RS02860	COG1254	Belongs to the acylphosphatase family
EHF33_RS02865	COG2873	o-acetylhomoserine
EHF33_RS02870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EHF33_RS02875	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EHF33_RS02885	COG1459	type II secretion system
EHF33_RS02890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EHF33_RS02900	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EHF33_RS02920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EHF33_RS02925	COG0488	(ABC) transporter
EHF33_RS02935	COG2199	diguanylate cyclase activity
EHF33_RS02940	COG0492	ferredoxin-NADP+ reductase activity
EHF33_RS02965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS02970	COG0601	transmembrane transport
EHF33_RS02975	COG0747	negative chemotaxis
EHF33_RS02995	COG0559	Belongs to the binding-protein-dependent transport system permease family
EHF33_RS03005	COG0174	glutamine synthetase
EHF33_RS03055	COG0557	exoribonuclease II activity
EHF33_RS03090	COG0582	viral genome integration into host DNA
EHF33_RS03210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EHF33_RS03210	COG0519	Catalyzes the synthesis of GMP from XMP
EHF33_RS03220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EHF33_RS03230	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EHF33_RS03235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EHF33_RS03265	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
EHF33_RS03270	COG2197	response regulator
EHF33_RS03275	COG1185	polyribonucleotide nucleotidyltransferase activity
EHF33_RS03280	COG0850	regulation of cytokinetic process
EHF33_RS03285	COG1902	pentaerythritol trinitrate reductase activity
EHF33_RS03295	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EHF33_RS03350	COG2226	methyltransferase
EHF33_RS03365	COG2363	Small membrane protein
EHF33_RS03370	COG2001	Belongs to the MraZ family
EHF33_RS03375	COG0275	rRNA processing
EHF33_RS03385	COG0768	penicillin binding
EHF33_RS03390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHF33_RS03405	COG4591	ABC-type transport system involved in lipoprotein release permease component
EHF33_RS03415	COG1692	metallophosphoesterase
EHF33_RS03420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EHF33_RS03430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EHF33_RS03435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EHF33_RS03450	COG0066	3-isopropylmalate dehydratase activity
EHF33_RS03465	COG0189	ligase activity
EHF33_RS03470	COG1522	sequence-specific DNA binding
EHF33_RS03525	COG3263	regulation of cellular component size
EHF33_RS03530	COG1595	DNA-templated transcription, initiation
EHF33_RS03585	COG0300	oxidoreductase activity
EHF33_RS03590	COG1404	Belongs to the peptidase S8 family
EHF33_RS03600	COG3845	ABC transporter
EHF33_RS03610	COG4251	negative regulation of phosphorylation
EHF33_RS03615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EHF33_RS03620	COG1702	phosphate starvation-inducible protein PhoH
EHF33_RS03625	COG3424	synthase
EHF33_RS03630	COG1755	Isoprenylcysteine carboxyl methyltransferase
EHF33_RS03640	COG0714	Associated with various cellular activities
EHF33_RS03650	COG0728	peptidoglycan biosynthetic process
EHF33_RS03710	COG2255	four-way junction helicase activity
EHF33_RS03715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHF33_RS03720	COG2313	pseudouridylate synthase activity
EHF33_RS03745	COG2304	oxidoreductase activity
EHF33_RS03750	COG2304	oxidoreductase activity
EHF33_RS03760	COG0515	serine threonine protein kinase
EHF33_RS03760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHF33_RS03765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EHF33_RS03770	COG2304	oxidoreductase activity
EHF33_RS03775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EHF33_RS03800	COG1136	(ABC) transporter
EHF33_RS03810	COG1785	Belongs to the alkaline phosphatase family
EHF33_RS03815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EHF33_RS03820	COG0826	peptidase U32
EHF33_RS03830	COG0489	protein tyrosine kinase activity
EHF33_RS03855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EHF33_RS03865	COG1024	Enoyl-CoA hydratase
EHF33_RS03870	COG3206	protein involved in exopolysaccharide biosynthesis
EHF33_RS03905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHF33_RS03945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHF33_RS03985	COG4956	integral membrane protein (PIN domain superfamily)
EHF33_RS03990	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EHF33_RS04010	COG0315	cyclic pyranopterin monophosphate synthase activity
EHF33_RS04020	COG0010	Belongs to the arginase family
EHF33_RS04040	COG0640	Transcriptional regulator
EHF33_RS04045	COG2205	protein histidine kinase activity
EHF33_RS04050	COG0745	RESPONSE REGULATOR receiver
EHF33_RS04060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS04065	COG0601	transmembrane transport
EHF33_RS04075	COG5002	protein histidine kinase activity
EHF33_RS04085	COG1309	transcriptional regulator
EHF33_RS04090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EHF33_RS04095	COG0424	maF-like protein
EHF33_RS04100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EHF33_RS04120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EHF33_RS04130	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EHF33_RS04135	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EHF33_RS04140	COG0596	Alpha beta hydrolase
EHF33_RS04155	COG0617	tRNA 3'-terminal CCA addition
EHF33_RS04180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EHF33_RS04185	COG1380	Effector of murein hydrolase LrgA
EHF33_RS04190	COG1346	cytolysis
EHF33_RS04195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHF33_RS04200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EHF33_RS04205	COG4948	Mandelate Racemase Muconate Lactonizing
EHF33_RS04225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EHF33_RS04235	COG3663	DNA glycosylase
EHF33_RS04240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EHF33_RS04260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHF33_RS04280	COG1011	Hydrolase
EHF33_RS04290	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EHF33_RS04305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EHF33_RS04320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHF33_RS04345	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EHF33_RS04360	COG0438	transferase activity, transferring glycosyl groups
EHF33_RS04365	COG0438	transferase activity, transferring glycosyl groups
EHF33_RS04375	COG1215	transferase activity, transferring glycosyl groups
EHF33_RS04380	COG0110	maltose O-acetyltransferase activity
EHF33_RS04400	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EHF33_RS04400	COG0662	Cupin 2, conserved barrel domain protein
EHF33_RS04405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EHF33_RS04410	COG0129	dihydroxy-acid dehydratase activity
EHF33_RS04420	COG1715	Restriction endonuclease
EHF33_RS04425	COG1648	precorrin-2 dehydrogenase activity
EHF33_RS04425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EHF33_RS04430	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EHF33_RS04435	COG2311	Membrane
EHF33_RS04445	COG0702	epimerase
EHF33_RS04450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHF33_RS04465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EHF33_RS04465	COG1754	DNA topoisomerase type I activity
EHF33_RS04475	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EHF33_RS04480	COG1660	Displays ATPase and GTPase activities
EHF33_RS04500	COG0187	DNA topoisomerase II activity
EHF33_RS04505	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EHF33_RS04515	COG2124	cytochrome p450
EHF33_RS04535	COG4251	negative regulation of phosphorylation
EHF33_RS04540	COG0784	Response regulator, receiver
EHF33_RS04550	COG2814	Major facilitator Superfamily
EHF33_RS04575	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EHF33_RS04585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EHF33_RS04595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHF33_RS04610	COG0719	Fe-S assembly protein
EHF33_RS04625	COG0719	Fe-S assembly protein
EHF33_RS04630	COG0396	ATPase activity
EHF33_RS04635	COG0811	peptide transport
EHF33_RS04640	COG0848	biopolymer transport protein
EHF33_RS04665	COG0251	oxidation-reduction process
EHF33_RS04730	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHF33_RS04745	COG0210	DNA helicase
EHF33_RS04755	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EHF33_RS04770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EHF33_RS04780	COG0436	Aminotransferase
EHF33_RS04810	COG1960	acyl-CoA dehydrogenase activity
EHF33_RS04825	COG0542	response to heat
EHF33_RS04835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EHF33_RS04855	COG2856	Zn peptidase
EHF33_RS04860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHF33_RS04870	COG0750	zinc metalloprotease
EHF33_RS04875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EHF33_RS04895	COG1562	ergosterol biosynthetic process
EHF33_RS04900	COG2226	methyltransferase
EHF33_RS04940	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EHF33_RS04955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EHF33_RS04965	COG0438	transferase activity, transferring glycosyl groups
EHF33_RS04970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EHF33_RS04985	COG1476	TRANSCRIPTIONal
EHF33_RS04990	COG4555	ABC transporter
EHF33_RS05005	COG1307	EDD domain protein, DegV family
EHF33_RS05010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EHF33_RS05020	COG0483	inositol monophosphate 1-phosphatase activity
EHF33_RS05025	COG0017	Asparaginyl-tRNA synthetase
EHF33_RS05040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHF33_RS05060	COG3135	benzoate transporter
EHF33_RS05065	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EHF33_RS05070	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EHF33_RS05090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHF33_RS05095	COG2151	metal-sulfur cluster biosynthetic enzyme
EHF33_RS05100	COG3842	ATPase activity
EHF33_RS05125	COG0702	epimerase
EHF33_RS05130	COG1918	ferrous iron import across plasma membrane
EHF33_RS05135	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EHF33_RS05135	COG1918	ferrous iron import across plasma membrane
EHF33_RS05145	COG0431	NADPH-dependent FMN reductase
EHF33_RS05150	COG0366	Alpha amylase catalytic
EHF33_RS05165	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EHF33_RS05175	COG0521	Mo-molybdopterin cofactor biosynthetic process
EHF33_RS05185	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EHF33_RS05195	COG4989	oxidoreductase activity
EHF33_RS05200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EHF33_RS05205	COG0742	ribosomal rna small subunit methyltransferase
EHF33_RS05215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EHF33_RS05220	COG0512	Glutamine amidotransferase of anthranilate synthase
EHF33_RS05235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EHF33_RS05245	COG3942	CHAP domain
EHF33_RS05245	COG1388	LysM domain
EHF33_RS05275	COG0513	Belongs to the DEAD box helicase family
EHF33_RS05280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EHF33_RS05295	COG0590	tRNA wobble adenosine to inosine editing
EHF33_RS05295	COG0037	tRNA processing
EHF33_RS05305	COG3844	kynureninase activity
EHF33_RS05310	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EHF33_RS05345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHF33_RS05350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EHF33_RS05355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EHF33_RS05365	COG0604	alcohol dehydrogenase
EHF33_RS05365	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS05365	COG3321	synthase
EHF33_RS05380	COG0358	DNA primase activity
EHF33_RS05395	COG0803	Belongs to the bacterial solute-binding protein 9 family
EHF33_RS05400	COG1121	(ABC) transporter
EHF33_RS05405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EHF33_RS05425	COG0423	glycine-tRNA ligase activity
EHF33_RS05430	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EHF33_RS05435	COG2720	vancomycin resistance protein
EHF33_RS05440	COG0024	Methionine aminopeptidase
EHF33_RS05445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EHF33_RS05450	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EHF33_RS05465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EHF33_RS05470	COG0779	Required for maturation of 30S ribosomal subunits
EHF33_RS05475	COG0195	Participates in both transcription termination and antitermination
EHF33_RS05485	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EHF33_RS05515	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EHF33_RS05515	COG1672	PFAM Archaeal ATPase
EHF33_RS05570	COG1546	Belongs to the CinA family
EHF33_RS05570	COG1058	Belongs to the CinA family
EHF33_RS05575	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EHF33_RS05580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EHF33_RS05600	COG1181	Belongs to the D-alanine--D-alanine ligase family
EHF33_RS05610	COG0601	transmembrane transport
EHF33_RS05615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS05620	COG0793	Belongs to the peptidase S41A family
EHF33_RS05635	COG1418	mRNA catabolic process
EHF33_RS05640	COG2226	methyltransferase
EHF33_RS05650	COG2177	Part of the ABC transporter FtsEX involved in
EHF33_RS05655	COG2884	Cell division ATP-binding protein ftsE
EHF33_RS05660	COG3409	Peptidoglycan-binding domain 1 protein
EHF33_RS05660	COG0793	Belongs to the peptidase S41A family
EHF33_RS05665	COG1378	Sugar-specific transcriptional regulator TrmB
EHF33_RS05690	COG0686	Belongs to the AlaDH PNT family
EHF33_RS05705	COG1999	signal sequence binding
EHF33_RS05710	COG0612	Peptidase, M16
EHF33_RS05720	COG1304	FMN binding
EHF33_RS05740	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EHF33_RS05745	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EHF33_RS05750	COG0134	indole-3-glycerol-phosphate synthase activity
EHF33_RS05760	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS05770	COG0154	amidase activity
EHF33_RS05780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EHF33_RS05805	COG1653	transport
EHF33_RS05810	COG1175	transmembrane transport
EHF33_RS05825	COG0575	Belongs to the CDS family
EHF33_RS05830	COG0233	cytoplasmic translational termination
EHF33_RS05835	COG0528	UMP kinase activity
EHF33_RS05840	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EHF33_RS05845	COG0052	Belongs to the universal ribosomal protein uS2 family
EHF33_RS05855	COG1187	pseudouridine synthase activity
EHF33_RS05875	COG0504	CTP synthase activity
EHF33_RS05915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHF33_RS05915	COG0515	serine threonine protein kinase
EHF33_RS05920	COG0113	porphobilinogen synthase activity
EHF33_RS05930	COG0765	amino acid transport
EHF33_RS05935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHF33_RS05940	COG3842	ATPase activity
EHF33_RS05965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EHF33_RS05980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHF33_RS06010	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHF33_RS06015	COG0411	ABC transporter
EHF33_RS06030	COG1803	Methylglyoxal synthase
EHF33_RS06040	COG0792	nuclease activity
EHF33_RS06050	COG0717	Belongs to the dCTP deaminase family
EHF33_RS06065	COG0667	Aldo Keto reductase
EHF33_RS06070	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EHF33_RS06080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHF33_RS06080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHF33_RS06100	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EHF33_RS06110	COG0492	ferredoxin-NADP+ reductase activity
EHF33_RS06120	COG4302	ethanolamine ammonia-lyase activity
EHF33_RS06135	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EHF33_RS06145	COG0778	Nitroreductase
EHF33_RS06160	COG1760	l-serine dehydratase
EHF33_RS06165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHF33_RS06175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EHF33_RS06180	COG5001	Diguanylate cyclase
EHF33_RS06180	COG3300	MHYT domain
EHF33_RS06185	COG0514	ATP-dependent DNA helicase (RecQ)
EHF33_RS06200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EHF33_RS06205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EHF33_RS06210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHF33_RS06235	COG0697	spore germination
EHF33_RS06260	COG0243	molybdopterin cofactor binding
EHF33_RS06265	COG1505	serine-type exopeptidase activity
EHF33_RS06295	COG0084	hydrolase, TatD family'
EHF33_RS06300	COG3706	GGDEF domain
EHF33_RS06305	COG0363	glucosamine-6-phosphate deaminase activity
EHF33_RS06315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EHF33_RS06320	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EHF33_RS06355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EHF33_RS06360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EHF33_RS06365	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EHF33_RS06375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EHF33_RS06380	COG1940	carbohydrate kinase activity
EHF33_RS06385	COG0765	amino acid transport
EHF33_RS06405	COG1970	mechanosensitive ion channel activity
EHF33_RS06415	COG2855	membrane
EHF33_RS06420	COG0583	DNA-binding transcription factor activity
EHF33_RS06425	COG2318	DinB family
EHF33_RS06430	COG1160	GTP binding
EHF33_RS06445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EHF33_RS06455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHF33_RS06465	COG1047	Peptidyl-prolyl cis-trans
EHF33_RS06485	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EHF33_RS06500	COG1131	(ABC) transporter
EHF33_RS06515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EHF33_RS06525	COG0217	transcriptional regulatory protein
EHF33_RS06535	COG1959	2 iron, 2 sulfur cluster binding
EHF33_RS06540	COG1764	response to oxidative stress
EHF33_RS06545	COG1132	(ABC) transporter
EHF33_RS06555	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHF33_RS06560	COG0529	Catalyzes the synthesis of activated sulfate
EHF33_RS06565	COG0175	sulfate reduction
EHF33_RS06570	COG2046	Belongs to the sulfate adenylyltransferase family
EHF33_RS06580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHF33_RS06585	COG3842	ATPase activity
EHF33_RS06590	COG0366	Alpha amylase catalytic
EHF33_RS06590	COG1874	Beta-galactosidase
EHF33_RS06610	COG1410	methionine synthase
EHF33_RS06610	COG0646	methionine synthase
EHF33_RS06625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHF33_RS06630	COG1864	DNA RNA non-specific endonuclease
EHF33_RS06630	COG3591	Belongs to the peptidase S1B family
EHF33_RS06660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EHF33_RS06670	COG0138	bifunctional purine biosynthesis protein purh
EHF33_RS06675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EHF33_RS06685	COG0632	four-way junction helicase activity
EHF33_RS06695	COG0604	alcohol dehydrogenase
EHF33_RS06700	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS06710	COG2076	Multidrug Resistance protein
EHF33_RS06715	COG3226	Transcriptional regulator
EHF33_RS06725	COG0788	formyltetrahydrofolate deformylase activity
EHF33_RS06735	COG1940	carbohydrate kinase activity
EHF33_RS06770	COG0483	inositol monophosphate 1-phosphatase activity
EHF33_RS06780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EHF33_RS06795	COG2823	Periplasmic or secreted lipoprotein
EHF33_RS06795	COG1652	LysM domain
EHF33_RS06825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EHF33_RS06840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EHF33_RS06865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EHF33_RS06875	COG0746	molybdenum cofactor guanylyltransferase activity
EHF33_RS06880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EHF33_RS06905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHF33_RS06910	COG2814	Major facilitator Superfamily
EHF33_RS06915	COG0737	Belongs to the 5'-nucleotidase family
EHF33_RS06925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EHF33_RS06935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EHF33_RS06940	COG3361	conserved protein (COG2071)
EHF33_RS06945	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EHF33_RS06950	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EHF33_RS06970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EHF33_RS06975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EHF33_RS06980	COG0131	Imidazoleglycerol-phosphate dehydratase
EHF33_RS06985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EHF33_RS06990	COG1396	sequence-specific DNA binding
EHF33_RS07005	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EHF33_RS07010	COG0285	dihydrofolate synthase activity
EHF33_RS07015	COG1227	inorganic diphosphatase activity
EHF33_RS07020	COG3206	protein involved in exopolysaccharide biosynthesis
EHF33_RS07030	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EHF33_RS07045	COG2095	MarC family integral membrane protein
EHF33_RS07050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EHF33_RS07055	COG2224	Isocitrate lyase
EHF33_RS07070	COG0335	large ribosomal subunit rRNA binding
EHF33_RS07075	COG0039	L-malate dehydrogenase activity
EHF33_RS07085	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EHF33_RS07125	COG2247	cell wall binding repeat
EHF33_RS07125	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHF33_RS07140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EHF33_RS07145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EHF33_RS07150	COG1253	flavin adenine dinucleotide binding
EHF33_RS07155	COG0295	cytidine deaminase activity
EHF33_RS07190	COG0151	Belongs to the GarS family
EHF33_RS07210	COG0747	negative chemotaxis
EHF33_RS07215	COG0601	transmembrane transport
EHF33_RS07220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS07245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EHF33_RS07275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EHF33_RS07280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHF33_RS07295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EHF33_RS07305	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EHF33_RS07325	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EHF33_RS07335	COG2217	Heavy metal translocating P-type atpase
EHF33_RS07350	COG1960	acyl-CoA dehydrogenase activity
EHF33_RS07360	COG1079	Belongs to the binding-protein-dependent transport system permease family
EHF33_RS07365	COG4603	Belongs to the binding-protein-dependent transport system permease family
EHF33_RS07370	COG0105	UTP biosynthetic process
EHF33_RS07375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EHF33_RS07380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EHF33_RS07385	COG2203	Gaf domain
EHF33_RS07385	COG4585	Histidine kinase
EHF33_RS07415	COG0681	Belongs to the peptidase S26 family
EHF33_RS07435	COG0628	permease
EHF33_RS07445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EHF33_RS07465	COG0281	malic enzyme
EHF33_RS07470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EHF33_RS07480	COG0284	orotidine-5'-phosphate decarboxylase activity
EHF33_RS07500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EHF33_RS07510	COG1573	uracil-dna glycosylase
EHF33_RS07525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EHF33_RS07530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHF33_RS07540	COG1490	D-aminoacyl-tRNA deacylase activity
EHF33_RS07545	COG1196	nuclear chromosome segregation
EHF33_RS07545	COG0741	lytic transglycosylase activity
EHF33_RS07545	COG0739	heme binding
EHF33_RS07555	COG0203	ribosomal protein L17
EHF33_RS07560	COG0202	RNA polymerase activity
EHF33_RS07565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EHF33_RS07570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EHF33_RS07575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EHF33_RS07580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EHF33_RS07585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EHF33_RS07590	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EHF33_RS07595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHF33_RS07605	COG0497	DNA recombination
EHF33_RS07620	COG4948	Mandelate Racemase Muconate Lactonizing
EHF33_RS07630	COG0488	(ABC) transporter
EHF33_RS07640	COG0123	including yeast histone deacetylase and acetoin utilization protein
EHF33_RS07645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EHF33_RS07650	COG0586	Pfam SNARE associated Golgi protein
EHF33_RS07655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHF33_RS07660	COG3437	response regulator, receiver
EHF33_RS07685	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EHF33_RS07690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EHF33_RS07695	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EHF33_RS07705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EHF33_RS07725	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EHF33_RS07745	COG2860	membrane
EHF33_RS07760	COG2949	membrane
EHF33_RS07765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EHF33_RS07775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EHF33_RS07780	COG1607	acyl-coa hydrolase
EHF33_RS07790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EHF33_RS07795	COG1796	DNA polymerase
EHF33_RS07795	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EHF33_RS07800	COG0683	leucine binding
EHF33_RS07805	COG0559	Belongs to the binding-protein-dependent transport system permease family
EHF33_RS07835	COG0585	pseudouridine synthase activity
EHF33_RS07850	COG1653	transport
EHF33_RS07860	COG0395	ABC-type sugar transport system, permease component
EHF33_RS07870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHF33_RS07870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHF33_RS07880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EHF33_RS07890	COG0581	inorganic phosphate transmembrane transporter activity
EHF33_RS07895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EHF33_RS07900	COG0704	Plays a role in the regulation of phosphate uptake
EHF33_RS07905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EHF33_RS07910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHF33_RS07925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EHF33_RS07930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EHF33_RS07940	COG1957	nucleoside hydrolase
EHF33_RS07950	COG1394	ATPase activity, coupled to movement of substances
EHF33_RS07955	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
EHF33_RS07960	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
EHF33_RS07965	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
EHF33_RS07970	COG1527	subunit (C
EHF33_RS07975	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
EHF33_RS07985	COG1269	ATP hydrolysis coupled proton transport
EHF33_RS07995	COG0004	ammonium transporteR
EHF33_RS08010	COG0193	aminoacyl-tRNA hydrolase activity
EHF33_RS08040	COG2096	Adenosyltransferase
EHF33_RS08045	COG1556	Lactate utilization protein
EHF33_RS08050	COG1139	Iron-sulfur cluster binding protein
EHF33_RS08055	COG0247	lactate metabolic process
EHF33_RS08060	COG1070	Carbohydrate kinase
EHF33_RS08065	COG3347	Dehydrogenase
EHF33_RS08065	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS08070	COG4952	isomerase
EHF33_RS08075	COG1349	DNA-binding transcription factor activity
EHF33_RS08080	COG3254	rhamnose metabolic process
EHF33_RS08085	COG1129	ABC transporter
EHF33_RS08090	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHF33_RS08105	COG0300	oxidoreductase activity
EHF33_RS08145	COG1450	Type ii and iii secretion system protein
EHF33_RS08150	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EHF33_RS08155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EHF33_RS08160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EHF33_RS08165	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EHF33_RS08170	COG2819	hydrolase of the alpha beta superfamily
EHF33_RS08185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EHF33_RS08190	COG4589	Belongs to the CDS family
EHF33_RS08195	COG0204	Acyl-transferase
EHF33_RS08200	COG2267	carboxylic ester hydrolase activity
EHF33_RS08205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EHF33_RS08215	COG1695	Transcriptional regulator
EHF33_RS08235	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EHF33_RS08255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EHF33_RS08275	COG0297	glycogen (starch) synthase activity
EHF33_RS08285	COG4585	Histidine kinase
EHF33_RS08290	COG1193	negative regulation of DNA recombination
EHF33_RS08300	COG2309	aminopeptidase activity
EHF33_RS08310	COG2124	cytochrome p450
EHF33_RS08315	COG1363	Peptidase, m42
EHF33_RS08325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EHF33_RS08330	COG0776	regulation of translation
EHF33_RS08335	COG1732	Glycine betaine
EHF33_RS08340	COG1174	glycine betaine transport
EHF33_RS08345	COG0517	IMP dehydrogenase activity
EHF33_RS08345	COG1125	glycine betaine transport
EHF33_RS08350	COG1174	glycine betaine transport
EHF33_RS08360	COG4628	conserved protein (DUF2132)
EHF33_RS08390	COG0567	Dehydrogenase, E1 component
EHF33_RS08395	COG0667	Aldo Keto reductase
EHF33_RS08400	COG1678	Uncharacterized ACR, COG1678
EHF33_RS08405	COG0154	amidase activity
EHF33_RS08410	COG1605	Chorismate mutase
EHF33_RS08410	COG0077	Prephenate dehydratase
EHF33_RS08430	COG2137	regulation of response to DNA damage stimulus
EHF33_RS08435	COG0268	Binds directly to 16S ribosomal RNA
EHF33_RS08440	COG0488	(ABC) transporter
EHF33_RS08455	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EHF33_RS08460	COG0540	Belongs to the ATCase OTCase family
EHF33_RS08465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EHF33_RS08470	COG3483	tryptophan 2,3-dioxygenase activity
EHF33_RS08475	COG1774	PSP1 C-terminal conserved region
EHF33_RS08480	COG0556	nucleotide-excision repair
EHF33_RS08495	COG0688	phosphatidylethanolamine metabolic process
EHF33_RS08510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHF33_RS08510	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EHF33_RS08515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHF33_RS08515	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EHF33_RS08520	COG3012	SEC-C Motif Domain Protein
EHF33_RS08525	COG4106	trans-aconitate 2-methyltransferase activity
EHF33_RS08545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHF33_RS08550	COG2197	response regulator
EHF33_RS08555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EHF33_RS08570	COG0372	Belongs to the citrate synthase family
EHF33_RS08575	COG0563	adenylate kinase activity
EHF33_RS08580	COG0201	protein transport
EHF33_RS08585	COG0200	Binds to the 23S rRNA
EHF33_RS08590	COG1841	ribosomal large subunit assembly
EHF33_RS08595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EHF33_RS08600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EHF33_RS08605	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EHF33_RS08610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EHF33_RS08615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EHF33_RS08620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EHF33_RS08625	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EHF33_RS08630	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EHF33_RS08635	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EHF33_RS08640	COG0255	Belongs to the universal ribosomal protein uL29 family
EHF33_RS08645	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EHF33_RS08650	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EHF33_RS08655	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EHF33_RS08660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EHF33_RS08665	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EHF33_RS08670	COG0089	rRNA binding
EHF33_RS08675	COG0088	Forms part of the polypeptide exit tunnel
EHF33_RS08680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EHF33_RS08685	COG0051	transcription antitermination factor activity, RNA binding
EHF33_RS08690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EHF33_RS08700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EHF33_RS08705	COG0049	tRNA binding
EHF33_RS08710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EHF33_RS08750	COG0318	PFAM AMP-dependent synthetase and ligase
EHF33_RS08765	COG0783	Belongs to the Dps family
EHF33_RS08770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHF33_RS08790	COG2389	metal-binding protein
EHF33_RS08795	COG1404	Belongs to the peptidase S8 family
EHF33_RS08800	COG0012	GTP binding
EHF33_RS08840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EHF33_RS08845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EHF33_RS08855	COG3447	MASE1 domain protein
EHF33_RS08855	COG5002	protein histidine kinase activity
EHF33_RS08855	COG5001	Diguanylate cyclase
EHF33_RS08860	COG1233	COG1233 Phytoene dehydrogenase and related
EHF33_RS08875	COG1472	Belongs to the glycosyl hydrolase 3 family
EHF33_RS08890	COG2205	protein histidine kinase activity
EHF33_RS08895	COG0745	RESPONSE REGULATOR receiver
EHF33_RS08905	COG0577	efflux transmembrane transporter activity
EHF33_RS08905	COG1136	(ABC) transporter
EHF33_RS08910	COG0577	efflux transmembrane transporter activity
EHF33_RS08910	COG1136	(ABC) transporter
EHF33_RS08920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHF33_RS08925	COG2318	DinB family
EHF33_RS08935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EHF33_RS08945	COG3706	GGDEF domain
EHF33_RS08950	COG0667	Aldo Keto reductase
EHF33_RS08980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EHF33_RS09030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EHF33_RS09035	COG1428	Deoxynucleoside kinase
EHF33_RS09040	COG1428	Deoxynucleoside kinase
EHF33_RS09045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EHF33_RS09055	COG0354	folic acid binding
EHF33_RS09065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EHF33_RS09075	COG2720	vancomycin resistance protein
EHF33_RS09080	COG1475	DNA binding
EHF33_RS09085	COG1192	Involved in chromosome partitioning
EHF33_RS09090	COG0357	Ribosomal RNA small subunit methyltransferase G
EHF33_RS09095	COG0445	tRNA wobble uridine modification
EHF33_RS09110	COG1131	(ABC) transporter
EHF33_RS09125	COG4585	Histidine kinase
EHF33_RS09130	COG2197	response regulator
EHF33_RS09140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EHF33_RS09145	COG1194	a g-specific adenine glycosylase
EHF33_RS09155	COG0587	DNA-directed DNA polymerase activity
EHF33_RS09165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EHF33_RS09170	COG0745	RESPONSE REGULATOR receiver
EHF33_RS09175	COG0745	RESPONSE REGULATOR receiver
EHF33_RS09190	COG0745	RESPONSE REGULATOR receiver
EHF33_RS09195	COG0745	RESPONSE REGULATOR receiver
EHF33_RS09200	COG0360	Binds together with S18 to 16S ribosomal RNA
EHF33_RS09205	COG0629	single-stranded DNA binding
EHF33_RS09210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EHF33_RS09215	COG0359	binds to the 23S rRNA
EHF33_RS09220	COG1570	exodeoxyribonuclease VII activity
EHF33_RS09225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EHF33_RS09230	COG0598	Magnesium transport protein CorA
EHF33_RS09245	COG1758	RNA polymerase activity
EHF33_RS09250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EHF33_RS09255	COG1438	arginine binding
EHF33_RS09265	COG3021	interspecies interaction between organisms
EHF33_RS09285	COG1024	Enoyl-CoA hydratase
EHF33_RS09295	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EHF33_RS09305	COG0194	GDP metabolic process
EHF33_RS09315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EHF33_RS09325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EHF33_RS09330	COG0406	alpha-ribazole phosphatase activity
EHF33_RS09345	COG1175	transmembrane transport
EHF33_RS09350	COG0395	ABC-type sugar transport system, permease component
EHF33_RS09365	COG0445	tRNA wobble uridine modification
EHF33_RS09420	COG2814	Major facilitator Superfamily
EHF33_RS09425	COG1690	Belongs to the RtcB family
EHF33_RS09435	COG0825	malonyl-CoA metabolic process
EHF33_RS09440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EHF33_RS09465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EHF33_RS09475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EHF33_RS09485	COG2027	D-alanyl-D-alanine carboxypeptidase
EHF33_RS09490	COG0419	ATPase involved in DNA repair
EHF33_RS09495	COG0420	3'-5' exonuclease activity
EHF33_RS09500	COG0438	transferase activity, transferring glycosyl groups
EHF33_RS09510	COG0737	Belongs to the 5'-nucleotidase family
EHF33_RS09515	COG0183	Belongs to the thiolase family
EHF33_RS09525	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHF33_RS09525	COG1024	Enoyl-CoA hydratase
EHF33_RS09530	COG2814	Major facilitator Superfamily
EHF33_RS09545	COG1213	nucleotidyl transferase
EHF33_RS09545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EHF33_RS09565	COG0802	atpase or kinase
EHF33_RS09590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EHF33_RS09590	COG0758	DNA mediated transformation
EHF33_RS09605	COG2197	response regulator
EHF33_RS09610	COG5002	protein histidine kinase activity
EHF33_RS09615	COG2205	protein histidine kinase activity
EHF33_RS09620	COG0702	epimerase
EHF33_RS09625	COG2354	Protein conserved in bacteria
EHF33_RS09635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHF33_RS09645	COG3290	protein histidine kinase activity
EHF33_RS09670	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EHF33_RS09700	COG2897	thiosulfate sulfurtransferase activity
EHF33_RS09715	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EHF33_RS09735	COG2223	nitrite transmembrane transporter activity
EHF33_RS09740	COG0432	Pfam Uncharacterised protein family UPF0047
EHF33_RS09785	COG1100	Small GTP-binding protein
EHF33_RS09820	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EHF33_RS09825	COG0714	Associated with various cellular activities
EHF33_RS09850	COG0799	negative regulation of ribosome biogenesis
EHF33_RS09865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EHF33_RS09870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EHF33_RS09875	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EHF33_RS09885	COG0181	hydroxymethylbilane synthase activity
EHF33_RS09910	COG1079	Belongs to the binding-protein-dependent transport system permease family
EHF33_RS09915	COG4603	Belongs to the binding-protein-dependent transport system permease family
EHF33_RS09920	COG3845	ABC transporter
EHF33_RS09945	COG2409	Drug exporters of the RND superfamily
EHF33_RS09975	COG1309	transcriptional regulator
EHF33_RS09990	COG0509	glycine decarboxylation via glycine cleavage system
EHF33_RS09995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EHF33_RS10005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EHF33_RS10025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EHF33_RS10030	COG0205	6-phosphofructokinase activity
EHF33_RS10035	COG0303	'Molybdopterin
EHF33_RS10040	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS10070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EHF33_RS10075	COG0469	pyruvate kinase activity
EHF33_RS10080	COG0148	phosphopyruvate hydratase activity
EHF33_RS10085	COG0592	DNA-directed DNA polymerase activity
EHF33_RS10090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EHF33_RS10100	COG0671	phosphoesterase, PA-phosphatase related
EHF33_RS10110	COG2321	neutral zinc metallopeptidase
EHF33_RS10115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EHF33_RS10125	COG0436	Aminotransferase
EHF33_RS10140	COG0288	reversible hydration of carbon dioxide
EHF33_RS10145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHF33_RS10150	COG0765	amino acid transport
EHF33_RS10155	COG0316	Belongs to the HesB IscA family
EHF33_RS10170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS10175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EHF33_RS10200	COG0343	queuine tRNA-ribosyltransferase activity
EHF33_RS10220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHF33_RS10220	COG3153	acetyltransferase
EHF33_RS10255	COG2385	sporulation resulting in formation of a cellular spore
EHF33_RS10285	COG1268	BioY protein
EHF33_RS10290	COG0135	phosphoribosylanthranilate isomerase activity
EHF33_RS10310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EHF33_RS10315	COG1324	tolerance protein
EHF33_RS10330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EHF33_RS10335	COG1408	metallophosphoesterase
EHF33_RS10395	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EHF33_RS10415	COG1129	ABC transporter
EHF33_RS10420	COG4856	YbbR-like protein
EHF33_RS10425	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EHF33_RS10430	COG2819	hydrolase of the alpha beta superfamily
EHF33_RS10440	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EHF33_RS10460	COG0513	Belongs to the DEAD box helicase family
EHF33_RS10475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHF33_RS10485	COG0745	RESPONSE REGULATOR receiver
EHF33_RS10495	COG0704	Plays a role in the regulation of phosphate uptake
EHF33_RS10500	COG0697	spore germination
EHF33_RS10505	COG1116	anion transmembrane transporter activity
EHF33_RS10525	COG0101	tRNA pseudouridine synthase activity
EHF33_RS10530	COG0739	heme binding
EHF33_RS10535	COG0321	lipoyl(octanoyl) transferase activity
EHF33_RS10540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EHF33_RS10555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHF33_RS10565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EHF33_RS10575	COG1175	transmembrane transport
EHF33_RS10580	COG0395	ABC-type sugar transport system, permease component
EHF33_RS10585	COG1472	Belongs to the glycosyl hydrolase 3 family
EHF33_RS10595	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EHF33_RS10600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EHF33_RS10630	COG0612	Peptidase, M16
EHF33_RS10640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHF33_RS10645	COG1316	TRANSCRIPTIONal
EHF33_RS10665	COG3088	subunit of a heme lyase
EHF33_RS10670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EHF33_RS10680	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EHF33_RS10690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHF33_RS10705	COG4133	protoheme IX ABC transporter activity
EHF33_RS10710	COG0785	Cytochrome C biogenesis protein
EHF33_RS10725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EHF33_RS10790	COG2309	aminopeptidase activity
EHF33_RS10810	COG1253	flavin adenine dinucleotide binding
EHF33_RS10830	COG0318	PFAM AMP-dependent synthetase and ligase
EHF33_RS10835	COG0745	RESPONSE REGULATOR receiver
EHF33_RS10840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EHF33_RS10875	COG0631	protein serine/threonine phosphatase activity
EHF33_RS10880	COG0251	oxidation-reduction process
EHF33_RS10885	COG1959	2 iron, 2 sulfur cluster binding
EHF33_RS10890	COG1522	sequence-specific DNA binding
EHF33_RS10920	COG2310	stress, protein
EHF33_RS10930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHF33_RS10935	COG1496	oxidoreductase activity
EHF33_RS10940	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EHF33_RS10945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EHF33_RS10955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EHF33_RS10965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EHF33_RS10970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EHF33_RS10975	COG2390	Transcriptional regulator
EHF33_RS10980	COG3118	belongs to the thioredoxin family
EHF33_RS10995	COG0416	fatty acid biosynthetic process
EHF33_RS11000	COG0668	transmembrane transport
EHF33_RS11015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EHF33_RS11065	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EHF33_RS11080	COG0582	viral genome integration into host DNA
EHF33_RS11085	COG0248	Ppx GppA phosphatase
EHF33_RS11130	COG1136	(ABC) transporter
EHF33_RS11135	COG1136	(ABC) transporter
EHF33_RS11135	COG0577	efflux transmembrane transporter activity
EHF33_RS11145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EHF33_RS11165	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EHF33_RS11175	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EHF33_RS11180	COG1136	(ABC) transporter
EHF33_RS11180	COG0577	efflux transmembrane transporter activity
EHF33_RS11185	COG0577	efflux transmembrane transporter activity
EHF33_RS11185	COG1136	(ABC) transporter
EHF33_RS11205	COG0242	peptide deformylase activity
EHF33_RS11210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EHF33_RS11220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EHF33_RS11225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EHF33_RS11230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EHF33_RS11265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EHF33_RS11265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EHF33_RS11285	COG0673	inositol 2-dehydrogenase activity
EHF33_RS11295	COG1879	ABC-type sugar transport system periplasmic component
EHF33_RS11300	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHF33_RS11305	COG1129	ABC transporter
EHF33_RS11335	COG0569	domain protein
EHF33_RS11350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHF33_RS11355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EHF33_RS11370	COG1595	DNA-templated transcription, initiation
EHF33_RS11380	COG0456	acetyltransferase
EHF33_RS11385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EHF33_RS11395	COG2165	general secretion pathway protein
EHF33_RS11405	COG2165	general secretion pathway protein
EHF33_RS11415	COG0740	serine-type endopeptidase activity
EHF33_RS11420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EHF33_RS11425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EHF33_RS11430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHF33_RS11445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EHF33_RS11455	COG2197	response regulator
EHF33_RS11480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EHF33_RS11490	COG0556	nucleotide-excision repair
EHF33_RS11500	COG1305	Transglutaminase-like
EHF33_RS11510	COG2308	Evidence 4 Homologs of previously reported genes of
EHF33_RS11515	COG0745	RESPONSE REGULATOR receiver
EHF33_RS11525	COG1132	(ABC) transporter
EHF33_RS11530	COG1132	(ABC) transporter
EHF33_RS11575	COG1695	Transcriptional regulator
EHF33_RS11625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHF33_RS11635	COG1957	nucleoside hydrolase
EHF33_RS11640	COG2205	protein histidine kinase activity
EHF33_RS11665	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EHF33_RS11670	COG0473	3-isopropylmalate dehydrogenase activity
EHF33_RS11695	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EHF33_RS11705	COG1051	belongs to the nudix hydrolase family
EHF33_RS11705	COG1056	cytidyltransferase-related domain
EHF33_RS11745	COG3191	aminopeptidase activity
EHF33_RS11750	COG0412	Dienelactone hydrolase
EHF33_RS11765	COG0302	gtp cyclohydrolase
EHF33_RS11770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EHF33_RS11785	COG0572	uridine kinase
EHF33_RS11800	COG1363	Peptidase, m42
EHF33_RS11805	COG2967	ApaG domain
EHF33_RS11815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EHF33_RS11835	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EHF33_RS11845	COG3870	Protein conserved in bacteria
EHF33_RS11850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EHF33_RS11850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHF33_RS11900	COG2267	carboxylic ester hydrolase activity
EHF33_RS11915	COG1960	acyl-CoA dehydrogenase activity
EHF33_RS11920	COG0657	acetylesterase activity
EHF33_RS11930	COG0183	Belongs to the thiolase family
EHF33_RS11935	COG0438	transferase activity, transferring glycosyl groups
EHF33_RS11940	COG1024	Enoyl-CoA hydratase
EHF33_RS11940	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHF33_RS11950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EHF33_RS11965	COG1695	Transcriptional regulator
EHF33_RS11990	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
EHF33_RS12000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHF33_RS12020	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHF33_RS12035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EHF33_RS12040	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EHF33_RS12045	COG0163	prenyltransferase activity
EHF33_RS12055	COG0708	Exodeoxyribonuclease III
EHF33_RS12060	COG1643	Atp-dependent helicase
EHF33_RS12065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EHF33_RS12065	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EHF33_RS12075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EHF33_RS12080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHF33_RS12085	COG0736	holo-[acyl-carrier-protein] synthase activity
EHF33_RS12090	COG0561	phosphatase activity
EHF33_RS12095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EHF33_RS12115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EHF33_RS12120	COG1053	succinate dehydrogenase
EHF33_RS12130	COG2009	succinate dehydrogenase
EHF33_RS12140	COG0515	serine threonine protein kinase
EHF33_RS12140	COG2815	serine threonine protein kinase
EHF33_RS12145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHF33_RS12160	COG0606	chelatase, subunit chli
EHF33_RS12175	COG0123	including yeast histone deacetylase and acetoin utilization protein
EHF33_RS12180	COG1842	Phage shock protein A
EHF33_RS12190	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
EHF33_RS12210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHF33_RS12220	COG1960	acyl-CoA dehydrogenase activity
EHF33_RS12250	COG0702	epimerase
EHF33_RS12265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EHF33_RS12270	COG0463	Glycosyl transferase, family 2
EHF33_RS12285	COG0582	viral genome integration into host DNA
EHF33_RS12295	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EHF33_RS12320	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
EHF33_RS12345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHF33_RS12375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHF33_RS12380	COG0277	FAD linked oxidase domain protein
EHF33_RS12385	COG0277	FAD linked oxidase domain protein
EHF33_RS12390	COG0247	lactate metabolic process
EHF33_RS12400	COG1132	(ABC) transporter
EHF33_RS12425	COG0730	response to heat
EHF33_RS12435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EHF33_RS12440	COG0179	Fumarylacetoacetate (FAA) hydrolase
EHF33_RS12455	COG2890	protein-(glutamine-N5) methyltransferase activity
EHF33_RS12475	COG1309	transcriptional regulator
EHF33_RS12495	COG0442	prolyl-tRNA aminoacylation
EHF33_RS12510	COG0569	domain protein
EHF33_RS12515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EHF33_RS12520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EHF33_RS12535	COG2124	cytochrome p450
EHF33_RS12540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EHF33_RS12550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHF33_RS12560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EHF33_RS12565	COG0215	cysteine-tRNA ligase activity
EHF33_RS12580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EHF33_RS12585	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EHF33_RS12590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EHF33_RS12595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EHF33_RS12600	COG0772	Belongs to the SEDS family
EHF33_RS12605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EHF33_RS12610	COG0384	phenazine biosynthesis protein PhzF
EHF33_RS12615	COG2267	carboxylic ester hydrolase activity
EHF33_RS12620	COG3206	protein involved in exopolysaccharide biosynthesis
EHF33_RS12625	COG1764	response to oxidative stress
EHF33_RS12645	COG3956	TIGRFAM MazG family protein
EHF33_RS12655	COG0542	response to heat
EHF33_RS12680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EHF33_RS12690	COG2323	membrane
EHF33_RS12695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHF33_RS12715	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EHF33_RS12720	COG0477	Major facilitator Superfamily
EHF33_RS12755	COG0745	RESPONSE REGULATOR receiver
EHF33_RS12765	COG0018	arginyl-trna synthetase
EHF33_RS12785	COG1331	Highly conserved protein containing a thioredoxin domain
EHF33_RS12830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHF33_RS12840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EHF33_RS12845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EHF33_RS12850	COG0085	RNA polymerase activity
EHF33_RS12855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EHF33_RS12880	COG0318	PFAM AMP-dependent synthetase and ligase
EHF33_RS12900	COG3253	May function as heme-dependent peroxidase
EHF33_RS12905	COG0557	exoribonuclease II activity
EHF33_RS12930	COG0673	inositol 2-dehydrogenase activity
EHF33_RS12940	COG0693	protein deglycase activity
EHF33_RS13005	COG5002	protein histidine kinase activity
EHF33_RS13015	COG0285	dihydrofolate synthase activity
EHF33_RS13020	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EHF33_RS13025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EHF33_RS13030	COG0544	peptidyl-prolyl cis-trans isomerase activity
EHF33_RS13050	COG0006	proline dipeptidase activity
EHF33_RS13060	COG0484	heat shock protein binding
EHF33_RS13065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EHF33_RS13070	COG0443	Heat shock 70 kDa protein
EHF33_RS13075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EHF33_RS13090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHF33_RS13100	COG0697	spore germination
EHF33_RS13105	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EHF33_RS13115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EHF33_RS13120	COG0706	membrane insertase activity
EHF33_RS13135	COG1628	Protein of unknown function DUF99
EHF33_RS13145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EHF33_RS13160	COG0539	negative regulation of cytoplasmic translation
EHF33_RS13175	COG0564	pseudouridine synthase activity
EHF33_RS13180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EHF33_RS13190	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS13195	COG0667	Aldo Keto reductase
EHF33_RS13200	COG0667	Aldo Keto reductase
EHF33_RS13205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EHF33_RS13210	COG0259	pyridoxamine-phosphate oxidase activity
EHF33_RS13225	COG1764	response to oxidative stress
EHF33_RS13230	COG1252	NADH dehydrogenase
EHF33_RS13235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EHF33_RS13240	COG0653	protein targeting
EHF33_RS13250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EHF33_RS13270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EHF33_RS13285	COG1832	CoA-binding protein
EHF33_RS13290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EHF33_RS13295	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EHF33_RS13305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EHF33_RS13330	COG0228	four-way junction DNA binding
EHF33_RS13335	COG1837	Belongs to the UPF0109 family
EHF33_RS13340	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EHF33_RS13345	COG0336	Belongs to the RNA methyltransferase TrmD family
EHF33_RS13355	COG0114	fumarate hydratase activity
EHF33_RS13370	COG4251	negative regulation of phosphorylation
EHF33_RS13385	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EHF33_RS13390	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EHF33_RS13395	COG0564	pseudouridine synthase activity
EHF33_RS13410	COG3426	butyrate kinase activity
EHF33_RS13415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHF33_RS13420	COG0617	tRNA 3'-terminal CCA addition
EHF33_RS13425	COG1846	Transcriptional regulator
EHF33_RS13430	COG0616	signal peptide processing
EHF33_RS13435	COG1744	ABC transporter substrate-binding protein PnrA-like
EHF33_RS13440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EHF33_RS13455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EHF33_RS13460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EHF33_RS13465	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EHF33_RS13475	COG2301	Belongs to the HpcH HpaI aldolase family
EHF33_RS13480	COG2030	dehydratase
EHF33_RS13485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHF33_RS13490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHF33_RS13495	COG1960	acyl-CoA dehydrogenase activity
EHF33_RS13500	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EHF33_RS13505	COG0477	Major facilitator Superfamily
EHF33_RS13515	COG1994	Peptidase M50
EHF33_RS13520	COG1272	protein, Hemolysin III
EHF33_RS13530	COG0516	GMP reductase activity
EHF33_RS13530	COG0517	IMP dehydrogenase activity
EHF33_RS13540	COG1309	transcriptional regulator
EHF33_RS13565	COG2326	polyphosphate kinase activity
EHF33_RS13585	COG1217	gtp-binding protein TYPA
EHF33_RS13590	COG1506	peptidase
EHF33_RS13590	COG0823	Involved in the tonB-independent uptake of proteins
EHF33_RS13590	COG4946	Tricorn protease homolog
EHF33_RS13600	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EHF33_RS13605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EHF33_RS13665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHF33_RS13665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHF33_RS13680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EHF33_RS13685	COG1968	undecaprenyl-diphosphatase activity
EHF33_RS13705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EHF33_RS13710	COG0140	phosphoribosyl-ATP diphosphatase activity
EHF33_RS13710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EHF33_RS13715	COG0107	imidazoleglycerol-phosphate synthase activity
EHF33_RS13800	COG3177	Filamentation induced by cAMP protein fic
EHF33_RS13860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EHF33_RS13905	COG0745	RESPONSE REGULATOR receiver
EHF33_RS13925	COG2323	membrane
EHF33_RS14020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EHF33_RS14035	COG3973	AAA domain
EHF33_RS14090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EHF33_RS14090	COG2169	Transcriptional regulator
EHF33_RS14175	COG1175	transmembrane transport
EHF33_RS14180	COG0395	ABC-type sugar transport system, permease component
EHF33_RS14185	COG3250	beta-galactosidase activity
EHF33_RS14220	COG3920	Histidine kinase
EHF33_RS14230	COG1695	Transcriptional regulator
EHF33_RS14240	COG0442	prolyl-tRNA aminoacylation
EHF33_RS14245	COG0596	Alpha beta hydrolase
EHF33_RS14265	COG1695	Transcriptional regulator
EHF33_RS14270	COG1695	Transcriptional regulator
EHF33_RS14285	COG0784	Response regulator, receiver
EHF33_RS14285	COG4191	Histidine kinase
EHF33_RS14290	COG3300	MHYT domain
EHF33_RS14290	COG5001	Diguanylate cyclase
EHF33_RS14305	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EHF33_RS14470	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EHF33_RS14475	COG4974	Belongs to the 'phage' integrase family
EHF33_RS14480	COG2032	superoxide dismutase activity
EHF33_RS14490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EHF33_RS14525	COG0784	Response regulator, receiver
EHF33_RS14525	COG2205	protein histidine kinase activity
EHF33_RS14530	COG2201	protein-glutamate methylesterase activity
EHF33_RS14540	COG0745	RESPONSE REGULATOR receiver
EHF33_RS14550	COG1486	melibiose metabolic process
EHF33_RS14555	COG1653	transport
EHF33_RS14560	COG0395	ABC-type sugar transport system, permease component
EHF33_RS14580	COG3437	response regulator, receiver
EHF33_RS14580	COG2770	Histidine kinase
EHF33_RS14605	COG2272	Belongs to the type-B carboxylesterase lipase family
EHF33_RS14675	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
EHF33_RS14685	COG2326	polyphosphate kinase activity
EHF33_RS14700	COG5001	Diguanylate cyclase
EHF33_RS14700	COG4251	negative regulation of phosphorylation
EHF33_RS14700	COG2203	Gaf domain
EHF33_RS14700	COG3706	GGDEF domain
EHF33_RS14730	COG1358	cellular component organization or biogenesis
EHF33_RS14740	COG2354	Protein conserved in bacteria
EHF33_RS14745	COG1285	pathogenesis
EHF33_RS14750	COG0586	Pfam SNARE associated Golgi protein
EHF33_RS14755	COG0861	Integral membrane protein TerC family
EHF33_RS14760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EHF33_RS14765	COG0772	Belongs to the SEDS family
EHF33_RS14780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EHF33_RS14810	COG3437	response regulator, receiver
EHF33_RS14810	COG2770	Histidine kinase
EHF33_RS14815	COG3706	GGDEF domain
EHF33_RS14820	COG3437	response regulator, receiver
EHF33_RS14820	COG2770	Histidine kinase
EHF33_RS14830	COG1132	(ABC) transporter
EHF33_RS14835	COG1132	(ABC) transporter
EHF33_RS14840	COG2239	Acts as a magnesium transporter
EHF33_RS14850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EHF33_RS14900	COG5001	Diguanylate cyclase
EHF33_RS14925	COG0783	Belongs to the Dps family
EHF33_RS15065	COG0642	Histidine kinase
EHF33_RS15070	COG0745	RESPONSE REGULATOR receiver
EHF33_RS15105	COG2897	thiosulfate sulfurtransferase activity
EHF33_RS15205	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EHF33_RS15210	COG0039	L-malate dehydrogenase activity
EHF33_RS15225	COG0666	response to abiotic stimulus
EHF33_RS15270	COG2304	oxidoreductase activity
EHF33_RS15300	COG2197	response regulator
EHF33_RS15305	COG2205	protein histidine kinase activity
EHF33_RS15315	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EHF33_RS15325	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EHF33_RS15330	COG2205	protein histidine kinase activity
EHF33_RS15350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EHF33_RS15385	COG0785	Cytochrome C biogenesis protein
EHF33_RS15410	COG1063	alcohol dehydrogenase
EHF33_RS15420	COG4214	carbohydrate transport
EHF33_RS15435	COG2390	Transcriptional regulator
EHF33_RS15485	COG2801	Transposase and inactivated derivatives
EHF33_RS15510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EHF33_RS15535	COG1450	Type ii and iii secretion system protein
EHF33_RS15545	COG1459	type II secretion system
EHF33_RS15625	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS15645	COG1846	Transcriptional regulator
EHF33_RS15645	COG1940	carbohydrate kinase activity
EHF33_RS15650	COG2182	Extracellular solute-binding protein
EHF33_RS15655	COG1175	transmembrane transport
EHF33_RS15660	COG0395	ABC-type sugar transport system, permease component
EHF33_RS15680	COG2130	NADP-dependent
EHF33_RS15685	COG2801	Transposase and inactivated derivatives
EHF33_RS15715	COG1396	sequence-specific DNA binding
EHF33_RS15720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EHF33_RS15800	COG1175	transmembrane transport
EHF33_RS15805	COG0395	ABC-type sugar transport system, permease component
EHF33_RS15810	COG1621	beta-fructofuranosidase activity
EHF33_RS15830	COG2843	Capsule synthesis protein
EHF33_RS15925	COG0395	ABC-type sugar transport system, permease component
EHF33_RS15930	COG1175	transmembrane transport
EHF33_RS16015	COG0642	Histidine kinase
EHF33_RS16020	COG0745	RESPONSE REGULATOR receiver
EHF33_RS16025	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EHF33_RS16055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHF33_RS16060	COG0667	Aldo Keto reductase
EHF33_RS16100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHF33_RS16115	COG0583	DNA-binding transcription factor activity
EHF33_RS16150	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
EHF33_RS16160	COG0346	lactoylglutathione lyase activity
EHF33_RS16165	COG0400	carboxylic ester hydrolase activity
EHF33_RS16215	COG0277	FAD linked oxidase domain protein
EHF33_RS16225	COG1012	belongs to the aldehyde dehydrogenase family
EHF33_RS16310	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EHF33_RS16315	COG1222	aaa ATPase
EHF33_RS16370	COG1511	domain protein
EHF33_RS16370	COG1511	domain protein
EHF33_RS16375	COG1309	transcriptional regulator
EHF33_RS16380	COG1846	Transcriptional regulator
EHF33_RS16385	COG2814	Major facilitator Superfamily
EHF33_RS16395	COG2072	flavoprotein involved in K transport
EHF33_RS16400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHF33_RS16410	COG1192	Involved in chromosome partitioning
EHF33_RS16420	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS16460	COG0515	serine threonine protein kinase
EHF33_RS16460	COG2815	serine threonine protein kinase
EHF33_RS16505	COG0745	RESPONSE REGULATOR receiver
EHF33_RS16510	COG0642	Histidine kinase
EHF33_RS16540	COG1879	ABC-type sugar transport system periplasmic component
EHF33_RS16545	COG1129	ABC transporter
EHF33_RS16550	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHF33_RS16555	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHF33_RS16560	COG0668	transmembrane transport
EHF33_RS16575	COG3345	alpha-galactosidase
EHF33_RS16585	COG1085	galactose-1-phosphate uridylyltransferase
EHF33_RS16600	COG1175	transmembrane transport
EHF33_RS16605	COG2182	Extracellular solute-binding protein
EHF33_RS16610	COG1349	DNA-binding transcription factor activity
EHF33_RS16615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EHF33_RS16620	COG0473	3-isopropylmalate dehydrogenase activity
EHF33_RS16660	COG0493	'glutamate synthase
EHF33_RS16665	COG1609	Transcriptional regulator
EHF33_RS16670	COG4213	ABC transporter substrate-binding protein
EHF33_RS16675	COG4214	carbohydrate transport
EHF33_RS16680	COG1129	ABC transporter
EHF33_RS16690	COG1070	Carbohydrate kinase
EHF33_RS16735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EHF33_RS16775	COG2252	PERMEase
EHF33_RS16780	COG0402	S-adenosylhomocysteine deaminase activity
EHF33_RS16790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EHF33_RS16800	COG1609	Transcriptional regulator
EHF33_RS16810	COG1175	transmembrane transport
EHF33_RS16820	COG1072	(Pantothenic acid kinase))
EHF33_RS16830	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS16835	COG1063	alcohol dehydrogenase
EHF33_RS16860	COG0584	glycerophosphoryl diester phosphodiesterase
EHF33_RS16865	COG0640	Transcriptional regulator
EHF33_RS16880	COG3833	ABC-type maltose transport systems, permease component
EHF33_RS16885	COG1175	transmembrane transport
EHF33_RS16895	COG1309	transcriptional regulator
EHF33_RS16915	COG2351	hydroxyisourate hydrolase activity
EHF33_RS16925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EHF33_RS16940	COG0655	NAD(P)H dehydrogenase (quinone) activity
EHF33_RS16950	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EHF33_RS16950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHF33_RS16990	COG1609	Transcriptional regulator
EHF33_RS17000	COG1175	transmembrane transport
EHF33_RS17005	COG0395	ABC-type sugar transport system, permease component
EHF33_RS17015	COG0366	Alpha amylase catalytic
EHF33_RS17030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHF33_RS17035	COG0166	Belongs to the GPI family
EHF33_RS17040	COG1024	Enoyl-CoA hydratase
EHF33_RS17050	COG1960	acyl-CoA dehydrogenase activity
EHF33_RS17055	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS17085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHF33_RS17095	COG2050	protein possibly involved in aromatic compounds catabolism
EHF33_RS17105	COG2272	Belongs to the type-B carboxylesterase lipase family
EHF33_RS17110	COG1404	Belongs to the peptidase S8 family
EHF33_RS17120	COG0702	epimerase
EHF33_RS17130	COG2188	Transcriptional regulator
EHF33_RS17135	COG0747	negative chemotaxis
EHF33_RS17140	COG0601	transmembrane transport
EHF33_RS17145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS17150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHF33_RS17155	COG4597	amino acid ABC transporter
EHF33_RS17160	COG0765	amino acid transport
EHF33_RS17165	COG1126	abc transporter atp-binding protein
EHF33_RS17170	COG1960	acyl-CoA dehydrogenase activity
EHF33_RS17175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHF33_RS17185	COG2706	6-phosphogluconolactonase activity
EHF33_RS17190	COG3424	synthase
EHF33_RS17215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EHF33_RS17235	COG0395	ABC-type sugar transport system, permease component
EHF33_RS17240	COG1175	transmembrane transport
EHF33_RS17250	COG0165	Argininosuccinate lyase
EHF33_RS17255	COG1064	alcohol dehydrogenase
EHF33_RS17260	COG1960	acyl-CoA dehydrogenase activity
EHF33_RS17280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EHF33_RS17285	COG4251	negative regulation of phosphorylation
EHF33_RS17310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EHF33_RS17320	COG1228	amidohydrolase
EHF33_RS17325	COG2986	histidine ammonia-lyase
EHF33_RS17335	COG2814	Major facilitator Superfamily
EHF33_RS17355	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS17365	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHF33_RS17395	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EHF33_RS17405	COG0659	secondary active sulfate transmembrane transporter activity
EHF33_RS17410	COG3396	Phenylacetate-CoA oxygenase
EHF33_RS17425	COG2151	metal-sulfur cluster biosynthetic enzyme
EHF33_RS17435	COG1012	belongs to the aldehyde dehydrogenase family
EHF33_RS17435	COG2030	dehydratase
EHF33_RS17460	COG3685	Protein conserved in bacteria
EHF33_RS17465	COG3835	regulator
EHF33_RS17470	COG1012	belongs to the aldehyde dehydrogenase family
EHF33_RS17480	COG2368	4-hydroxyphenylacetate
EHF33_RS17505	COG3971	2-oxopent-4-enoate hydratase activity
EHF33_RS17515	COG2199	diguanylate cyclase activity
EHF33_RS17520	COG0070	glutamate synthase
EHF33_RS17520	COG0069	glutamate synthase activity
EHF33_RS17520	COG0067	glutamate synthase
EHF33_RS17545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EHF33_RS17570	COG2217	Heavy metal translocating P-type atpase
EHF33_RS17580	COG2373	Large extracellular alpha-helical protein
EHF33_RS17595	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EHF33_RS17600	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EHF33_RS17605	COG0601	transmembrane transport
EHF33_RS17615	COG4608	Belongs to the ABC transporter superfamily
EHF33_RS17630	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EHF33_RS17650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS17655	COG0601	transmembrane transport
EHF33_RS17665	COG4948	Mandelate Racemase Muconate Lactonizing
EHF33_RS17670	COG1609	Transcriptional regulator
EHF33_RS17680	COG1486	melibiose metabolic process
EHF33_RS17685	COG0363	glucosamine-6-phosphate deaminase activity
EHF33_RS17695	COG3217	Mosc domain protein beta barrel domain protein
EHF33_RS17695	COG0633	Ferredoxin
EHF33_RS17710	COG0673	inositol 2-dehydrogenase activity
EHF33_RS17725	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EHF33_RS17765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHF33_RS17785	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EHF33_RS17800	COG0411	ABC transporter
EHF33_RS17815	COG0683	leucine binding
EHF33_RS17820	COG0683	leucine binding
EHF33_RS17835	COG0167	dihydroorotate dehydrogenase activity
EHF33_RS17835	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EHF33_RS17850	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EHF33_RS17860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHF33_RS17865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHF33_RS17870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHF33_RS17885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHF33_RS17895	COG1414	Transcriptional regulator
EHF33_RS17900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EHF33_RS17910	COG2084	Dehydrogenase
EHF33_RS17915	COG3622	Belongs to the hyi family
EHF33_RS17920	COG3960	tartronate-semialdehyde synthase activity
EHF33_RS17925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EHF33_RS17935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EHF33_RS17985	COG1486	melibiose metabolic process
EHF33_RS18005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EHF33_RS18025	COG1175	transmembrane transport
EHF33_RS18035	COG1349	DNA-binding transcription factor activity
EHF33_RS18050	COG2801	Transposase and inactivated derivatives
EHF33_RS18055	COG2801	Transposase and inactivated derivatives
EHF33_RS18085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHF33_RS18100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHF33_RS18100	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EHF33_RS18105	COG3938	Belongs to the proline racemase family
EHF33_RS18155	COG4187	Peptidase family M20/M25/M40
EHF33_RS18175	COG2801	Transposase and inactivated derivatives
EHF33_RS18185	COG2199	diguanylate cyclase activity
EHF33_RS18185	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EHF33_RS18190	COG3706	GGDEF domain
EHF33_RS18215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHF33_RS18220	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EHF33_RS18225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHF33_RS18230	COG1120	ATPase activity
EHF33_RS18235	COG1797	cobyrinic acid a,c-diamide synthase activity
EHF33_RS18260	COG1472	Belongs to the glycosyl hydrolase 3 family
EHF33_RS18265	COG2723	6-phospho-beta-galactosidase activity
EHF33_RS18270	COG0395	ABC-type sugar transport system, permease component
EHF33_RS18275	COG1175	transmembrane transport
EHF33_RS18285	COG1609	Transcriptional regulator
EHF33_RS18290	COG5002	protein histidine kinase activity
EHF33_RS18295	COG0745	RESPONSE REGULATOR receiver
EHF33_RS18300	COG0671	phosphoesterase, PA-phosphatase related
EHF33_RS18335	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
EHF33_RS18350	COG0516	GMP reductase activity
EHF33_RS18350	COG0517	IMP dehydrogenase activity
EHF33_RS18365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHF33_RS18380	COG0747	negative chemotaxis
EHF33_RS18390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS18400	COG4608	Belongs to the ABC transporter superfamily
EHF33_RS18415	COG0569	domain protein
EHF33_RS18420	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS18430	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EHF33_RS18435	COG4221	oxidoreductase activity
EHF33_RS18440	COG1446	asparaginase
EHF33_RS18445	COG1522	sequence-specific DNA binding
EHF33_RS18465	COG4177	L-phenylalanine transmembrane transporter activity
EHF33_RS18470	COG0683	leucine binding
EHF33_RS18480	COG0174	glutamine synthetase
EHF33_RS18490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS18500	COG0747	negative chemotaxis
EHF33_RS18510	COG3718	enzyme involved in inositol metabolism
EHF33_RS18515	COG0673	inositol 2-dehydrogenase activity
EHF33_RS18525	COG1082	Xylose isomerase domain protein TIM barrel
EHF33_RS18530	COG3962	Belongs to the TPP enzyme family
EHF33_RS18535	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EHF33_RS18540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EHF33_RS18540	COG0574	Belongs to the PEP-utilizing enzyme family
EHF33_RS18550	COG2770	Histidine kinase
EHF33_RS18550	COG3437	response regulator, receiver
EHF33_RS18555	COG4974	Belongs to the 'phage' integrase family
EHF33_RS18560	COG4221	oxidoreductase activity
EHF33_RS18565	COG1937	Protein conserved in bacteria
EHF33_RS18595	COG2267	carboxylic ester hydrolase activity
EHF33_RS18600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS18605	COG0601	transmembrane transport
EHF33_RS18610	COG4166	transmembrane transport
EHF33_RS18625	COG1363	Peptidase, m42
EHF33_RS18630	COG4251	negative regulation of phosphorylation
EHF33_RS18635	COG4251	negative regulation of phosphorylation
EHF33_RS18640	COG2186	Transcriptional regulator
EHF33_RS18645	COG0747	negative chemotaxis
EHF33_RS18650	COG0601	transmembrane transport
EHF33_RS18655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS18665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EHF33_RS18670	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS18680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHF33_RS18695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS18715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS18720	COG0598	Magnesium transport protein CorA
EHF33_RS18750	COG2199	diguanylate cyclase activity
EHF33_RS18755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EHF33_RS18760	COG2199	diguanylate cyclase activity
EHF33_RS18760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EHF33_RS18775	COG0006	proline dipeptidase activity
EHF33_RS18780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS18785	COG0601	transmembrane transport
EHF33_RS18820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHF33_RS18820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHF33_RS18830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHF33_RS18865	COG0666	response to abiotic stimulus
EHF33_RS18875	COG4566	intracellular signal transduction
EHF33_RS18880	COG4191	Histidine kinase
EHF33_RS18925	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS18940	COG0411	ABC transporter
EHF33_RS18955	COG2267	carboxylic ester hydrolase activity
EHF33_RS18965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EHF33_RS18980	COG1028	Short-chain dehydrogenase reductase Sdr
EHF33_RS18985	COG1846	Transcriptional regulator
EHF33_RS18990	COG1024	Enoyl-CoA hydratase
EHF33_RS18995	COG1960	acyl-CoA dehydrogenase activity
EHF33_RS19005	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EHF33_RS19010	COG0028	Belongs to the TPP enzyme family
EHF33_RS19030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHF33_RS19035	COG0601	transmembrane transport
EHF33_RS19040	COG0747	negative chemotaxis
EHF33_RS19050	COG0024	Methionine aminopeptidase
EHF33_RS19055	COG0006	proline dipeptidase activity
EHF33_RS19060	COG1104	cysteine desulfurase activity
EHF33_RS19065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHF33_RS19085	COG0346	lactoylglutathione lyase activity
EHF33_RS19120	COG0747	negative chemotaxis
EHF33_RS19125	COG1505	serine-type exopeptidase activity
EHF33_RS19140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EHF33_RS19150	COG3293	Transposase
EHF33_RS19175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EHF33_RS19190	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EHF33_RS19205	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EHF33_RS19210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHF33_RS19215	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EHF33_RS19220	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EHF33_RS19225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EHF33_RS19235	COG1917	Cupin 2, conserved barrel domain protein
EHF33_RS19245	COG2807	transmembrane transport
EHF33_RS19250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHF33_RS19255	COG0765	amino acid transport
EHF33_RS19285	COG1506	peptidase
EHF33_RS19285	COG4946	Tricorn protease homolog
EHF33_RS19285	COG0823	Involved in the tonB-independent uptake of proteins
EHF33_RS19295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EHF33_RS19310	COG3300	MHYT domain
EHF33_RS19310	COG5001	Diguanylate cyclase
EHF33_RS19325	COG0415	Belongs to the DNA photolyase family
EHF33_RS19335	COG1940	carbohydrate kinase activity
EHF33_RS19335	COG1846	Transcriptional regulator
EHF33_RS19340	COG1653	transport
EHF33_RS19345	COG1175	transmembrane transport
EHF33_RS19350	COG0395	ABC-type sugar transport system, permease component
EHF33_RS19380	COG1175	transmembrane transport
EHF33_RS19390	COG1073	alpha beta
EHF33_RS19420	COG0243	molybdopterin cofactor binding
EHF33_RS19505	COG2909	trisaccharide binding
EHF33_RS19545	COG0346	lactoylglutathione lyase activity
EHF33_RS19600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHF33_RS19605	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EHF33_RS19645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EHF33_RS19685	COG4251	negative regulation of phosphorylation
EHF33_RS19690	COG1366	Belongs to the anti-sigma-factor antagonist family
EHF33_RS19715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EHF33_RS19755	COG1366	Belongs to the anti-sigma-factor antagonist family
EHF33_RS19760	COG1366	Belongs to the anti-sigma-factor antagonist family
EHF33_RS19765	COG2172	sigma factor antagonist activity
EHF33_RS19805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EHF33_RS19855	COG1074	ATP-dependent DNA helicase activity
EHF33_RS19860	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EHF33_RS19900	COG1201	RNA secondary structure unwinding
EHF33_RS19925	COG1201	RNA secondary structure unwinding
EHF33_RS19935	COG1401	restriction endodeoxyribonuclease activity
EHF33_RS19960	COG3973	AAA domain
EHF33_RS19970	COG0419	ATPase involved in DNA repair
EHF33_RS19980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EHF33_RS20075	COG1484	DNA-dependent DNA replication
EHF33_RS20095	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EHF33_RS20105	COG1192	Involved in chromosome partitioning
EHF33_RS20150	COG4456	Virulence-associated protein
EHF33_RS20165	COG1902	pentaerythritol trinitrate reductase activity
EHF33_RS20185	COG3973	AAA domain
EHF33_RS20195	COG0305	Participates in initiation and elongation during chromosome replication
EHF33_RS20200	COG0305	Participates in initiation and elongation during chromosome replication
EHF33_RS20210	COG2304	oxidoreductase activity
EHF33_RS20240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EHF33_RS20275	COG1228	amidohydrolase
EHF33_RS20360	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
EHF33_RS20370	COG4245	von Willebrand factor, type A
EHF33_RS20415	COG1002	Type II restriction enzyme, methylase subunits
EHF33_RS20525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EHF33_RS20620	COG1192	Involved in chromosome partitioning
EHF33_RS20815	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EHF33_RS20830	COG2337	Toxic component of a toxin-antitoxin (TA) module
EHF33_RS20880	COG1475	DNA binding
EHF33_RS20915	COG1404	Belongs to the peptidase S8 family
EHF33_RS20950	COG0489	protein tyrosine kinase activity