locus-tag	class	description
I6H54_RS00020	COG0783	Belongs to the Dps family
I6H54_RS00025	COG0671	phosphoesterase, PA-phosphatase related
I6H54_RS00030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6H54_RS00055	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS00060	COG0028	Belongs to the TPP enzyme family
I6H54_RS00075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6H54_RS00085	COG3842	ATPase activity
I6H54_RS00090	COG3842	ATPase activity
I6H54_RS00100	COG0395	ABC-type sugar transport system, permease component
I6H54_RS00115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6H54_RS00120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6H54_RS00125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H54_RS00130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H54_RS00135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H54_RS00140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6H54_RS00145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6H54_RS00150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6H54_RS00155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H54_RS00160	COG1841	ribosomal large subunit assembly
I6H54_RS00165	COG0200	Binds to the 23S rRNA
I6H54_RS00170	COG0201	protein transport
I6H54_RS00175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H54_RS00180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H54_RS00185	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H54_RS00190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H54_RS00195	COG0202	RNA polymerase activity
I6H54_RS00200	COG0203	ribosomal protein L17
I6H54_RS00215	COG0471	metal ion transport
I6H54_RS00230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H54_RS00235	COG4172	Belongs to the ABC transporter superfamily
I6H54_RS00240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H54_RS00250	COG0747	negative chemotaxis
I6H54_RS00265	COG0443	Heat shock 70 kDa protein
I6H54_RS00275	COG0792	nuclease activity
I6H54_RS00280	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6H54_RS00285	COG2823	Periplasmic or secreted lipoprotein
I6H54_RS00290	COG2084	Dehydrogenase
I6H54_RS00300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H54_RS00310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H54_RS00325	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS00330	COG4770	biotin carboxylase activity
I6H54_RS00340	COG0545	Peptidyl-prolyl cis-trans isomerase
I6H54_RS00350	COG3604	Transcriptional regulator
I6H54_RS00370	COG0583	DNA-binding transcription factor activity
I6H54_RS00375	COG0277	FAD linked oxidase domain protein
I6H54_RS00400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6H54_RS00430	COG5002	protein histidine kinase activity
I6H54_RS00445	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6H54_RS00450	COG0439	Biotin carboxylase
I6H54_RS00465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6H54_RS00470	COG2204	response regulator
I6H54_RS00485	COG4771	TonB-dependent receptor
I6H54_RS00495	COG2733	membrane
I6H54_RS00510	COG4585	Histidine kinase
I6H54_RS00515	COG2197	response regulator
I6H54_RS00545	COG2223	nitrite transmembrane transporter activity
I6H54_RS00550	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6H54_RS00555	COG1140	nitrate reductase beta subunit
I6H54_RS00560	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6H54_RS00565	COG2181	nitrate reductase activity
I6H54_RS00570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H54_RS00575	COG0288	reversible hydration of carbon dioxide
I6H54_RS00585	COG3945	hemerythrin HHE cation binding domain
I6H54_RS00595	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6H54_RS00600	COG0277	FAD linked oxidase domain protein
I6H54_RS00610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6H54_RS00615	COG2814	Major facilitator Superfamily
I6H54_RS00665	COG0243	molybdopterin cofactor binding
I6H54_RS00675	COG1473	amidohydrolase
I6H54_RS00680	COG3842	ATPase activity
I6H54_RS00710	COG1116	anion transmembrane transporter activity
I6H54_RS00715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H54_RS00725	COG2194	sulfuric ester hydrolase activity
I6H54_RS00730	COG0745	RESPONSE REGULATOR receiver
I6H54_RS00750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6H54_RS00760	COG0667	Aldo Keto reductase
I6H54_RS00800	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6H54_RS00815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H54_RS00820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS00825	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS00845	COG1187	pseudouridine synthase activity
I6H54_RS00850	COG1595	DNA-templated transcription, initiation
I6H54_RS00855	COG3712	iron ion homeostasis
I6H54_RS00865	COG3128	pkhd-type hydroxylase
I6H54_RS00870	COG4774	siderophore transport
I6H54_RS00875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H54_RS00880	COG0326	Molecular chaperone. Has ATPase activity
I6H54_RS00900	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6H54_RS00905	COG0830	nickel cation binding
I6H54_RS00910	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6H54_RS00920	COG0804	urea catabolic process
I6H54_RS00925	COG0832	Belongs to the urease beta subunit family
I6H54_RS00935	COG0831	urea catabolic process
I6H54_RS00940	COG0829	nickel cation binding
I6H54_RS00945	COG2814	Major facilitator Superfamily
I6H54_RS00970	COG5001	Diguanylate cyclase
I6H54_RS00970	COG4251	negative regulation of phosphorylation
I6H54_RS00970	COG2203	Gaf domain
I6H54_RS00970	COG3706	GGDEF domain
I6H54_RS00985	COG1764	response to oxidative stress
I6H54_RS00990	COG1846	Transcriptional regulator
I6H54_RS01000	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H54_RS01015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H54_RS01030	COG4566	intracellular signal transduction
I6H54_RS01035	COG4191	Histidine kinase
I6H54_RS01040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H54_RS01045	COG1490	D-aminoacyl-tRNA deacylase activity
I6H54_RS01050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H54_RS01065	COG0730	response to heat
I6H54_RS01070	COG0583	DNA-binding transcription factor activity
I6H54_RS01080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS01085	COG0604	alcohol dehydrogenase
I6H54_RS01090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6H54_RS01095	COG1702	phosphate starvation-inducible protein PhoH
I6H54_RS01100	COG0632	four-way junction helicase activity
I6H54_RS01105	COG2255	four-way junction helicase activity
I6H54_RS01110	COG1285	pathogenesis
I6H54_RS01170	COG0747	negative chemotaxis
I6H54_RS01175	COG0601	transmembrane transport
I6H54_RS01180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H54_RS01195	COG0037	tRNA processing
I6H54_RS01245	COG0617	tRNA 3'-terminal CCA addition
I6H54_RS01260	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6H54_RS01265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H54_RS01270	COG1196	nuclear chromosome segregation
I6H54_RS01270	COG0741	lytic transglycosylase activity
I6H54_RS01270	COG0739	heme binding
I6H54_RS01280	COG3128	pkhd-type hydroxylase
I6H54_RS01285	COG4774	siderophore transport
I6H54_RS01295	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS01305	COG3186	Phenylalanine-4-hydroxylase
I6H54_RS01315	COG1522	sequence-specific DNA binding
I6H54_RS01330	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6H54_RS01335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6H54_RS01365	COG0583	DNA-binding transcription factor activity
I6H54_RS01370	COG1953	Uracil, thiamine, allantoin
I6H54_RS01375	COG2186	Transcriptional regulator
I6H54_RS01380	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H54_RS01385	COG3842	ATPase activity
I6H54_RS01405	COG4260	virion core protein, lumpy skin disease virus
I6H54_RS01410	COG0752	glycyl-tRNA synthetase alpha subunit
I6H54_RS01415	COG0751	glycine-tRNA ligase activity
I6H54_RS01420	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6H54_RS01425	COG0204	Acyl-transferase
I6H54_RS01440	COG0583	DNA-binding transcription factor activity
I6H54_RS01445	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS01455	COG1652	LysM domain
I6H54_RS01460	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6H54_RS01465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H54_RS01470	COG1459	type II secretion system
I6H54_RS01515	COG1450	Type ii and iii secretion system protein
I6H54_RS01530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H54_RS01565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6H54_RS01580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6H54_RS01585	COG0745	RESPONSE REGULATOR receiver
I6H54_RS01595	COG1309	transcriptional regulator
I6H54_RS01655	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS01665	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H54_RS01665	COG1024	Enoyl-CoA hydratase
I6H54_RS01670	COG0183	Belongs to the thiolase family
I6H54_RS01685	COG1024	Enoyl-CoA hydratase
I6H54_RS01710	COG1607	acyl-coa hydrolase
I6H54_RS01715	COG5265	(ABC) transporter
I6H54_RS01755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H54_RS01770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H54_RS01775	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6H54_RS01775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H54_RS01780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6H54_RS01785	COG0583	DNA-binding transcription factor activity
I6H54_RS01795	COG0765	amino acid transport
I6H54_RS01800	COG0765	amino acid transport
I6H54_RS01805	COG1126	abc transporter atp-binding protein
I6H54_RS01835	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS01840	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS01865	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS01885	COG0583	DNA-binding transcription factor activity
I6H54_RS01890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H54_RS01895	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6H54_RS01910	COG0418	dihydroorotase activity
I6H54_RS01925	COG0501	Belongs to the peptidase M48B family
I6H54_RS01935	COG0583	DNA-binding transcription factor activity
I6H54_RS01940	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H54_RS01940	COG1024	Enoyl-CoA hydratase
I6H54_RS01945	COG0183	Belongs to the thiolase family
I6H54_RS01950	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS01955	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS01960	COG1024	Enoyl-CoA hydratase
I6H54_RS01965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS02030	COG1473	amidohydrolase
I6H54_RS02035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6H54_RS02040	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6H54_RS02055	COG3210	domain, Protein
I6H54_RS02055	COG3210	domain, Protein
I6H54_RS02090	COG0405	Gamma-glutamyltransferase
I6H54_RS02100	COG0114	fumarate hydratase activity
I6H54_RS02115	COG2188	Transcriptional regulator
I6H54_RS02120	COG1132	(ABC) transporter
I6H54_RS02155	COG4977	sequence-specific DNA binding
I6H54_RS02170	COG3712	iron ion homeostasis
I6H54_RS02180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H54_RS02185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6H54_RS02195	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6H54_RS02200	COG0523	cobalamin synthesis protein
I6H54_RS02215	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6H54_RS02220	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6H54_RS02225	COG2001	Belongs to the MraZ family
I6H54_RS02230	COG0275	rRNA processing
I6H54_RS02245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H54_RS02250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H54_RS02255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H54_RS02260	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H54_RS02265	COG0772	Belongs to the SEDS family
I6H54_RS02270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H54_RS02275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H54_RS02280	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H54_RS02285	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6H54_RS02300	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6H54_RS02310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6H54_RS02315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H54_RS02320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6H54_RS02330	COG0557	exoribonuclease II activity
I6H54_RS02335	COG3150	esterase
I6H54_RS02340	COG0772	Belongs to the SEDS family
I6H54_RS02345	COG0312	modulator of DNA gyrase
I6H54_RS02355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6H54_RS02360	COG3098	single-species biofilm formation
I6H54_RS02370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H54_RS02380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H54_RS02385	COG0511	ligase activity, forming carbon-carbon bonds
I6H54_RS02390	COG0439	Biotin carboxylase
I6H54_RS02395	COG2264	protein methyltransferase activity
I6H54_RS02405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H54_RS02415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H54_RS02420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H54_RS02420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H54_RS02445	COG4137	Cytochrome C assembly protein
I6H54_RS02450	COG4251	negative regulation of phosphorylation
I6H54_RS02450	COG5001	Diguanylate cyclase
I6H54_RS02450	COG2203	Gaf domain
I6H54_RS02450	COG3706	GGDEF domain
I6H54_RS02460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H54_RS02465	COG0791	NLP P60 protein
I6H54_RS02490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H54_RS02500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6H54_RS02505	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6H54_RS02535	COG2814	Major facilitator Superfamily
I6H54_RS02570	COG1024	Enoyl-CoA hydratase
I6H54_RS02580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H54_RS02585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H54_RS02590	COG3217	Mosc domain protein beta barrel domain protein
I6H54_RS02590	COG0633	Ferredoxin
I6H54_RS02595	COG0012	GTP binding
I6H54_RS02610	COG4804	nuclease activity
I6H54_RS02625	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS02630	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS02645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6H54_RS02650	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS02660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H54_RS02675	COG4191	Histidine kinase
I6H54_RS02675	COG2205	protein histidine kinase activity
I6H54_RS02675	COG0745	RESPONSE REGULATOR receiver
I6H54_RS02680	COG4566	intracellular signal transduction
I6H54_RS02695	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6H54_RS02710	COG1741	Belongs to the pirin family
I6H54_RS02715	COG0583	DNA-binding transcription factor activity
I6H54_RS02720	COG1238	metal cluster binding
I6H54_RS02730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H54_RS02735	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6H54_RS02740	COG0138	bifunctional purine biosynthesis protein purh
I6H54_RS02745	COG4654	Cytochrome c, class I
I6H54_RS02750	COG2818	Glycosylase
I6H54_RS02760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6H54_RS02770	COG1773	rubredoxin
I6H54_RS02800	COG0415	Belongs to the DNA photolyase family
I6H54_RS02805	COG1678	Uncharacterized ACR, COG1678
I6H54_RS02810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6H54_RS02815	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6H54_RS02820	COG0540	Belongs to the ATCase OTCase family
I6H54_RS02825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6H54_RS02855	COG3842	ATPase activity
I6H54_RS02860	COG1178	ABC-type Fe3 transport system permease component
I6H54_RS02885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H54_RS02890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H54_RS02905	COG0642	Histidine kinase
I6H54_RS02910	COG5001	Diguanylate cyclase
I6H54_RS02910	COG3300	MHYT domain
I6H54_RS02930	COG0625	glutathione transferase activity
I6H54_RS02990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H54_RS03020	COG1280	lysine exporter protein (LysE YggA)
I6H54_RS03035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6H54_RS03040	COG1040	competence protein
I6H54_RS03045	COG2226	methyltransferase
I6H54_RS03060	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I6H54_RS03090	COG1999	signal sequence binding
I6H54_RS03095	COG0840	transmembrane signaling receptor activity
I6H54_RS03125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6H54_RS03140	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS03145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H54_RS03155	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS03160	COG1024	Enoyl-CoA hydratase
I6H54_RS03165	COG1042	CoA-binding domain protein
I6H54_RS03165	COG0045	succinate-CoA ligase (ADP-forming) activity
I6H54_RS03165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H54_RS03170	COG2079	MmgE PrpD family protein
I6H54_RS03225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H54_RS03240	COG0431	NADPH-dependent FMN reductase
I6H54_RS03270	COG2011	ABC-type metal ion transport system permease component
I6H54_RS03275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H54_RS03280	COG1464	Belongs to the NlpA lipoprotein family
I6H54_RS03285	COG1464	Belongs to the NlpA lipoprotein family
I6H54_RS03300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H54_RS03305	COG3971	2-oxopent-4-enoate hydratase activity
I6H54_RS03310	COG0300	oxidoreductase activity
I6H54_RS03320	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS03350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6H54_RS03355	COG1324	tolerance protein
I6H54_RS03360	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS03370	COG0612	Peptidase, M16
I6H54_RS03375	COG0612	Peptidase, M16
I6H54_RS03380	COG0742	ribosomal rna small subunit methyltransferase
I6H54_RS03385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6H54_RS03405	COG5487	UPF0391 membrane protein
I6H54_RS03415	COG2197	response regulator
I6H54_RS03430	COG0793	Belongs to the peptidase S41A family
I6H54_RS03435	COG0588	phosphoglycerate mutase activity
I6H54_RS03440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H54_RS03445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H54_RS03450	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6H54_RS03455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6H54_RS03465	COG0583	DNA-binding transcription factor activity
I6H54_RS03480	COG1473	amidohydrolase
I6H54_RS03490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6H54_RS03495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6H54_RS03505	COG1131	(ABC) transporter
I6H54_RS03545	COG0156	8-amino-7-oxononanoate synthase activity
I6H54_RS03560	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6H54_RS03570	COG0602	queuosine metabolic process
I6H54_RS03600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H54_RS03600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H54_RS03615	COG0489	protein tyrosine kinase activity
I6H54_RS03620	COG0583	DNA-binding transcription factor activity
I6H54_RS03635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H54_RS03635	COG2010	Cytochrome c
I6H54_RS03640	COG1335	isochorismatase
I6H54_RS03645	COG2309	aminopeptidase activity
I6H54_RS03650	COG0596	Alpha beta hydrolase
I6H54_RS03655	COG3473	Maleate cis-trans isomerase
I6H54_RS03665	COG2080	2 iron, 2 sulfur cluster binding
I6H54_RS03670	COG2010	Cytochrome c
I6H54_RS03670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H54_RS03675	COG0477	Major facilitator Superfamily
I6H54_RS03685	COG1846	Transcriptional regulator
I6H54_RS03695	COG3383	formate dehydrogenase (NAD+) activity
I6H54_RS03705	COG0583	DNA-binding transcription factor activity
I6H54_RS03725	COG4829	muconolactone delta-isomerase
I6H54_RS03750	COG2205	protein histidine kinase activity
I6H54_RS03750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H54_RS03760	COG0745	RESPONSE REGULATOR receiver
I6H54_RS03765	COG0745	RESPONSE REGULATOR receiver
I6H54_RS03785	COG4774	siderophore transport
I6H54_RS03795	COG2814	Major facilitator Superfamily
I6H54_RS03805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H54_RS03810	COG0697	spore germination
I6H54_RS03815	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS03820	COG0583	DNA-binding transcription factor activity
I6H54_RS03830	COG0583	DNA-binding transcription factor activity
I6H54_RS03840	COG0737	Belongs to the 5'-nucleotidase family
I6H54_RS03875	COG1595	DNA-templated transcription, initiation
I6H54_RS03880	COG2003	Belongs to the UPF0758 family
I6H54_RS03885	COG1047	Peptidyl-prolyl cis-trans
I6H54_RS03890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6H54_RS03895	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H54_RS03895	COG0617	tRNA 3'-terminal CCA addition
I6H54_RS03895	COG0517	IMP dehydrogenase activity
I6H54_RS03900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6H54_RS03925	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H54_RS03985	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6H54_RS04005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H54_RS04010	COG1228	amidohydrolase
I6H54_RS04015	COG0523	cobalamin synthesis protein
I6H54_RS04020	COG1987	bacterial-type flagellum assembly
I6H54_RS04025	COG1684	flagellar biosynthetic protein fliR
I6H54_RS04030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6H54_RS04035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6H54_RS04040	COG4786	Flagellar basal body rod
I6H54_RS04045	COG4786	Flagellar basal body rod
I6H54_RS04055	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6H54_RS04060	COG1706	bacterial-type flagellum-dependent cell motility
I6H54_RS04070	COG1558	bacterial-type flagellum-dependent cell motility
I6H54_RS04075	COG1677	Flagellar hook-basal body complex protein FliE
I6H54_RS04095	COG1157	protein secretion by the type III secretion system
I6H54_RS04110	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6H54_RS04115	COG1749	Flagellar hook protein flgE
I6H54_RS04125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6H54_RS04220	COG2855	membrane
I6H54_RS04235	COG1414	Transcriptional regulator
I6H54_RS04250	COG2267	carboxylic ester hydrolase activity
I6H54_RS04260	COG1999	signal sequence binding
I6H54_RS04270	COG3447	MASE1 domain protein
I6H54_RS04270	COG5001	Diguanylate cyclase
I6H54_RS04270	COG5002	protein histidine kinase activity
I6H54_RS04285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H54_RS04310	COG2146	nitrite reductase [NAD(P)H] activity
I6H54_RS04315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H54_RS04320	COG2207	Transcriptional regulator
I6H54_RS04325	COG2175	clavaminate synthase activity
I6H54_RS04330	COG3246	L-lysine catabolic process to acetate
I6H54_RS04350	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6H54_RS04355	COG0583	DNA-binding transcription factor activity
I6H54_RS04380	COG1113	amino acid transport
I6H54_RS04385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H54_RS04405	COG2951	lytic endotransglycosylase activity
I6H54_RS04415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H54_RS04420	COG1758	RNA polymerase activity
I6H54_RS04425	COG0194	GDP metabolic process
I6H54_RS04430	COG1561	YicC-like family, N-terminal region
I6H54_RS04445	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6H54_RS04450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H54_RS04470	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS04475	COG1609	Transcriptional regulator
I6H54_RS04485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6H54_RS04500	COG0789	Transcriptional regulator
I6H54_RS04510	COG0625	glutathione transferase activity
I6H54_RS04515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H54_RS04520	COG0300	oxidoreductase activity
I6H54_RS04575	COG0740	serine-type endopeptidase activity
I6H54_RS04605	COG4191	Histidine kinase
I6H54_RS04620	COG0438	transferase activity, transferring glycosyl groups
I6H54_RS04625	COG3604	Transcriptional regulator
I6H54_RS04675	COG4964	Belongs to the GSP D family
I6H54_RS04705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H54_RS04710	COG2274	protein secretion by the type I secretion system
I6H54_RS04720	COG2885	chlorophyll binding
I6H54_RS04755	COG0523	cobalamin synthesis protein
I6H54_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS04770	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS04785	COG0154	amidase activity
I6H54_RS04800	COG1309	transcriptional regulator
I6H54_RS04820	COG0281	malic enzyme
I6H54_RS04820	COG0280	phosphate acetyltransferase
I6H54_RS04825	COG2233	PERMEase
I6H54_RS04845	COG2186	Transcriptional regulator
I6H54_RS04850	COG0583	DNA-binding transcription factor activity
I6H54_RS04870	COG0583	DNA-binding transcription factor activity
I6H54_RS04875	COG3960	tartronate-semialdehyde synthase activity
I6H54_RS04880	COG3622	Belongs to the hyi family
I6H54_RS04885	COG2084	Dehydrogenase
I6H54_RS04890	COG0405	Gamma-glutamyltransferase
I6H54_RS04935	COG3300	MHYT domain
I6H54_RS04935	COG5001	Diguanylate cyclase
I6H54_RS04945	COG3447	MASE1 domain protein
I6H54_RS04945	COG5002	protein histidine kinase activity
I6H54_RS04945	COG5001	Diguanylate cyclase
I6H54_RS04965	COG3845	ABC transporter
I6H54_RS04970	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6H54_RS04995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6H54_RS05000	COG0537	adenosine 5'-monophosphoramidase activity
I6H54_RS05010	COG0402	S-adenosylhomocysteine deaminase activity
I6H54_RS05015	COG0717	Belongs to the dCTP deaminase family
I6H54_RS05020	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6H54_RS05025	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6H54_RS05035	COG2423	ornithine cyclodeaminase activity
I6H54_RS05045	COG2321	neutral zinc metallopeptidase
I6H54_RS05050	COG0513	Belongs to the DEAD box helicase family
I6H54_RS05055	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6H54_RS05060	COG1253	flavin adenine dinucleotide binding
I6H54_RS05065	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H54_RS05075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H54_RS05085	COG3483	tryptophan 2,3-dioxygenase activity
I6H54_RS05090	COG2169	Transcriptional regulator
I6H54_RS05090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H54_RS05095	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6H54_RS05105	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6H54_RS05110	COG1113	amino acid transport
I6H54_RS05115	COG2207	Transcriptional regulator
I6H54_RS05125	COG0251	oxidation-reduction process
I6H54_RS05130	COG3483	tryptophan 2,3-dioxygenase activity
I6H54_RS05135	COG1448	Aminotransferase
I6H54_RS05140	COG1113	amino acid transport
I6H54_RS05145	COG1522	sequence-specific DNA binding
I6H54_RS05150	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6H54_RS05170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H54_RS05175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6H54_RS05185	COG0268	Binds directly to 16S ribosomal RNA
I6H54_RS05190	COG0728	peptidoglycan biosynthetic process
I6H54_RS05205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H54_RS05210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H54_RS05220	COG0617	tRNA 3'-terminal CCA addition
I6H54_RS05270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H54_RS05285	COG2807	transmembrane transport
I6H54_RS05290	COG0590	tRNA wobble adenosine to inosine editing
I6H54_RS05295	COG0583	DNA-binding transcription factor activity
I6H54_RS05300	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS05305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS05310	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS05315	COG0583	DNA-binding transcription factor activity
I6H54_RS05320	COG1346	cytolysis
I6H54_RS05350	COG0425	Belongs to the sulfur carrier protein TusA family
I6H54_RS05355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H54_RS05360	COG0525	valine-tRNA ligase activity
I6H54_RS05375	COG3813	Protein conserved in bacteria
I6H54_RS05405	COG2353	YceI-like domain
I6H54_RS05435	COG0181	hydroxymethylbilane synthase activity
I6H54_RS05440	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6H54_RS05475	COG1722	exodeoxyribonuclease VII activity
I6H54_RS05480	COG0142	geranyltranstransferase activity
I6H54_RS05485	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6H54_RS05490	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6H54_RS05495	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6H54_RS05500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H54_RS05555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H54_RS05560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H54_RS05565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H54_RS05585	COG3279	Response regulator of the LytR AlgR family
I6H54_RS05590	COG2972	Histidine kinase
I6H54_RS05620	COG1968	undecaprenyl-diphosphatase activity
I6H54_RS05635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6H54_RS05675	COG3214	Protein conserved in bacteria
I6H54_RS05690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6H54_RS05700	COG0583	DNA-binding transcription factor activity
I6H54_RS05745	COG0640	Transcriptional regulator
I6H54_RS05750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H54_RS05755	COG0483	inositol monophosphate 1-phosphatase activity
I6H54_RS05765	COG1045	serine acetyltransferase
I6H54_RS05775	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6H54_RS05805	COG1518	maintenance of DNA repeat elements
I6H54_RS05810	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6H54_RS05815	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6H54_RS05820	COG1538	Outer membrane efflux protein
I6H54_RS05825	COG0577	efflux transmembrane transporter activity
I6H54_RS05825	COG1136	(ABC) transporter
I6H54_RS05830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H54_RS05840	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H54_RS05845	COG3028	Belongs to the UPF0307 family
I6H54_RS05850	COG0312	modulator of DNA gyrase
I6H54_RS05875	COG3264	Mechanosensitive ion channel
I6H54_RS05875	COG1511	domain protein
I6H54_RS05880	COG2766	serine protein kinase
I6H54_RS05885	COG2718	Belongs to the UPF0229 family
I6H54_RS05890	COG2719	SpoVR family
I6H54_RS05900	COG0004	ammonium transporteR
I6H54_RS05925	COG1309	transcriptional regulator
I6H54_RS05965	COG1012	belongs to the aldehyde dehydrogenase family
I6H54_RS05970	COG2721	sulfolactate sulfo-lyase activity
I6H54_RS05990	COG0633	Ferredoxin
I6H54_RS06010	COG1309	transcriptional regulator
I6H54_RS06015	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6H54_RS06020	COG2271	Major facilitator Superfamily
I6H54_RS06025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H54_RS06035	COG0473	3-isopropylmalate dehydrogenase activity
I6H54_RS06040	COG0583	DNA-binding transcription factor activity
I6H54_RS06050	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6H54_RS06055	COG2081	HI0933 family
I6H54_RS06060	COG1607	acyl-coa hydrolase
I6H54_RS06065	COG2205	protein histidine kinase activity
I6H54_RS06065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H54_RS06075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6H54_RS06080	COG0243	molybdopterin cofactor binding
I6H54_RS06085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H54_RS06090	COG0840	transmembrane signaling receptor activity
I6H54_RS06105	COG1116	anion transmembrane transporter activity
I6H54_RS06110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H54_RS06115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H54_RS06120	COG3707	response regulator
I6H54_RS06130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6H54_RS06140	COG0683	leucine binding
I6H54_RS06145	COG2951	lytic endotransglycosylase activity
I6H54_RS06160	COG0714	Associated with various cellular activities
I6H54_RS06170	COG1024	Enoyl-CoA hydratase
I6H54_RS06175	COG1511	domain protein
I6H54_RS06175	COG3264	Mechanosensitive ion channel
I6H54_RS06195	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS06205	COG4988	ABC transporter
I6H54_RS06210	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6H54_RS06220	COG1294	oxidase, subunit
I6H54_RS06240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H54_RS06260	COG4948	Mandelate Racemase Muconate Lactonizing
I6H54_RS06270	COG0583	DNA-binding transcription factor activity
I6H54_RS06275	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6H54_RS06280	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6H54_RS06295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H54_RS06300	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6H54_RS06305	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6H54_RS06315	COG0513	Belongs to the DEAD box helicase family
I6H54_RS06330	COG0372	Belongs to the citrate synthase family
I6H54_RS06335	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6H54_RS06340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6H54_RS06345	COG1053	succinate dehydrogenase
I6H54_RS06350	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6H54_RS06355	COG2009	succinate dehydrogenase
I6H54_RS06360	COG2188	Transcriptional regulator
I6H54_RS06365	COG0039	L-malate dehydrogenase activity
I6H54_RS06370	COG4106	trans-aconitate 2-methyltransferase activity
I6H54_RS06415	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6H54_RS06420	COG0583	DNA-binding transcription factor activity
I6H54_RS06425	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS06430	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS06435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS06455	COG0348	domain, Protein
I6H54_RS06460	COG0129	dihydroxy-acid dehydratase activity
I6H54_RS06470	COG4772	TonB-dependent receptor
I6H54_RS06475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H54_RS06485	COG0826	peptidase U32
I6H54_RS06500	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6H54_RS06505	COG1690	Belongs to the RtcB family
I6H54_RS06525	COG0824	Thioesterase
I6H54_RS06530	COG0436	Aminotransferase
I6H54_RS06535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H54_RS06540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6H54_RS06555	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS06560	COG2918	glutathione biosynthetic process
I6H54_RS06585	COG1473	amidohydrolase
I6H54_RS06595	COG0564	pseudouridine synthase activity
I6H54_RS06615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H54_RS06635	COG3064	Membrane
I6H54_RS06650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H54_RS06660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6H54_RS06675	COG3384	dioxygenase
I6H54_RS06690	COG1522	sequence-specific DNA binding
I6H54_RS06720	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6H54_RS06730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6H54_RS06740	COG0215	cysteine-tRNA ligase activity
I6H54_RS06755	COG0037	tRNA processing
I6H54_RS06800	COG0402	S-adenosylhomocysteine deaminase activity
I6H54_RS06810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H54_RS06815	COG0642	Histidine kinase
I6H54_RS06825	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS06910	COG0667	Aldo Keto reductase
I6H54_RS06955	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6H54_RS06970	COG0583	DNA-binding transcription factor activity
I6H54_RS06985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H54_RS07040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H54_RS07045	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6H54_RS07050	COG1011	Hydrolase
I6H54_RS07075	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6H54_RS07095	COG1562	ergosterol biosynthetic process
I6H54_RS07105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H54_RS07110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H54_RS07125	COG3550	peptidyl-serine autophosphorylation
I6H54_RS07360	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6H54_RS07365	COG0740	serine-type endopeptidase activity
I6H54_RS07370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6H54_RS07375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6H54_RS07405	COG0501	Belongs to the peptidase M48B family
I6H54_RS07425	COG1451	nucleotide metabolic process
I6H54_RS07430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H54_RS07450	COG0114	fumarate hydratase activity
I6H54_RS07460	COG2814	Major facilitator Superfamily
I6H54_RS07485	COG1609	Transcriptional regulator
I6H54_RS07490	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H54_RS07490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H54_RS07495	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H54_RS07500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H54_RS07500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H54_RS07505	COG2113	Glycine betaine
I6H54_RS07510	COG4176	ABC-type proline glycine betaine transport system permease component
I6H54_RS07515	COG4175	Glycine betaine
I6H54_RS07525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6H54_RS07535	COG4654	Cytochrome c, class I
I6H54_RS07545	COG0129	dihydroxy-acid dehydratase activity
I6H54_RS07555	COG1024	Enoyl-CoA hydratase
I6H54_RS07570	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS07575	COG1846	Transcriptional regulator
I6H54_RS07580	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6H54_RS07605	COG1024	Enoyl-CoA hydratase
I6H54_RS07615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS07620	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS07625	COG0589	response to stress
I6H54_RS07630	COG2217	Heavy metal translocating P-type atpase
I6H54_RS07640	COG3278	Belongs to the heme-copper respiratory oxidase family
I6H54_RS07660	COG0348	domain, Protein
I6H54_RS07675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H54_RS07680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H54_RS07695	COG5001	Diguanylate cyclase
I6H54_RS07695	COG3300	MHYT domain
I6H54_RS07700	COG0730	response to heat
I6H54_RS07715	COG1797	cobyrinic acid a,c-diamide synthase activity
I6H54_RS07725	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6H54_RS07730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H54_RS07735	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6H54_RS07745	COG1737	Transcriptional regulator
I6H54_RS07750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6H54_RS07765	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6H54_RS07770	COG0778	Nitroreductase
I6H54_RS07775	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6H54_RS07780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6H54_RS07785	COG1492	cobalamin metabolic process
I6H54_RS07800	COG3622	Belongs to the hyi family
I6H54_RS07805	COG3395	kinase activity
I6H54_RS07810	COG2084	Dehydrogenase
I6H54_RS07815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H54_RS07820	COG2271	Major facilitator Superfamily
I6H54_RS07825	COG0235	Class ii aldolase
I6H54_RS07830	COG2186	Transcriptional regulator
I6H54_RS07835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6H54_RS07875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H54_RS07880	COG4804	nuclease activity
I6H54_RS07890	COG0154	amidase activity
I6H54_RS07895	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS07900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H54_RS07905	COG2900	Belongs to the SlyX family
I6H54_RS07915	COG1473	amidohydrolase
I6H54_RS07920	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS07965	COG0583	DNA-binding transcription factor activity
I6H54_RS07980	COG1522	sequence-specific DNA binding
I6H54_RS07995	COG3530	Putative quorum-sensing-regulated virulence factor
I6H54_RS08005	COG0560	Phosphoserine phosphatase
I6H54_RS08015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H54_RS08020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6H54_RS08020	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6H54_RS08025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6H54_RS08025	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6H54_RS08045	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS08055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H54_RS08070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H54_RS08075	COG1309	transcriptional regulator
I6H54_RS08080	COG0493	'glutamate synthase
I6H54_RS08090	COG1953	Uracil, thiamine, allantoin
I6H54_RS08115	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS08115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H54_RS08115	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS08115	COG0300	oxidoreductase activity
I6H54_RS08115	COG3321	synthase
I6H54_RS08130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6H54_RS08135	COG3597	protein domain associated with
I6H54_RS08175	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
I6H54_RS08180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H54_RS08190	COG0534	Mate efflux family protein
I6H54_RS08200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H54_RS08210	COG0583	DNA-binding transcription factor activity
I6H54_RS08215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS08220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H54_RS08230	COG0322	excinuclease ABC activity
I6H54_RS08240	COG0776	regulation of translation
I6H54_RS08290	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H54_RS08485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H54_RS08500	COG4968	Prepilin-type N-terminal cleavage methylation domain
I6H54_RS08540	COG1335	isochorismatase
I6H54_RS08545	COG1335	isochorismatase
I6H54_RS08550	COG0583	DNA-binding transcription factor activity
I6H54_RS08565	COG0513	Belongs to the DEAD box helicase family
I6H54_RS08570	COG0488	(ABC) transporter
I6H54_RS08580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H54_RS08585	COG3191	aminopeptidase activity
I6H54_RS08600	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I6H54_RS08605	COG2132	Multicopper oxidase
I6H54_RS08635	COG0789	Transcriptional regulator
I6H54_RS08670	COG0784	Response regulator, receiver
I6H54_RS08670	COG2205	protein histidine kinase activity
I6H54_RS08670	COG2198	Histidine kinase
I6H54_RS08675	COG1301	dicarboxylic acid transport
I6H54_RS08685	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS08700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H54_RS08705	COG1696	Membrane protein involved in D-alanine export
I6H54_RS08725	COG1215	transferase activity, transferring glycosyl groups
I6H54_RS08735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6H54_RS08760	COG2814	Major facilitator Superfamily
I6H54_RS08795	COG0784	Response regulator, receiver
I6H54_RS08795	COG4191	Histidine kinase
I6H54_RS08800	COG3706	GGDEF domain
I6H54_RS08805	COG3284	Transcriptional regulator
I6H54_RS08815	COG1063	alcohol dehydrogenase
I6H54_RS08855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS08860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H54_RS08865	COG1414	Transcriptional regulator
I6H54_RS08890	COG4166	transmembrane transport
I6H54_RS08895	COG4174	ABC transporter (Permease)
I6H54_RS08900	COG4239	(ABC) transporter, permease
I6H54_RS08905	COG4172	Belongs to the ABC transporter superfamily
I6H54_RS08910	COG3040	lipid binding
I6H54_RS08930	COG2863	cytochrome
I6H54_RS08935	COG2010	Cytochrome c
I6H54_RS08935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H54_RS08945	COG0779	Required for maturation of 30S ribosomal subunits
I6H54_RS08950	COG0195	Participates in both transcription termination and antitermination
I6H54_RS08955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6H54_RS08960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H54_RS08965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H54_RS08975	COG0583	DNA-binding transcription factor activity
I6H54_RS08980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS08995	COG1024	Enoyl-CoA hydratase
I6H54_RS09015	COG1595	DNA-templated transcription, initiation
I6H54_RS09025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6H54_RS09030	COG2867	negative regulation of translational initiation
I6H54_RS09050	COG0129	dihydroxy-acid dehydratase activity
I6H54_RS09055	COG0583	DNA-binding transcription factor activity
I6H54_RS09070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6H54_RS09070	COG0519	Catalyzes the synthesis of GMP from XMP
I6H54_RS09080	COG0612	Peptidase, M16
I6H54_RS09110	COG1902	pentaerythritol trinitrate reductase activity
I6H54_RS09115	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H54_RS09125	COG2368	4-hydroxyphenylacetate
I6H54_RS09155	COG2072	flavoprotein involved in K transport
I6H54_RS09175	COG0583	DNA-binding transcription factor activity
I6H54_RS09185	COG2814	Major facilitator Superfamily
I6H54_RS09190	COG1027	Aspartate ammonia-lyase
I6H54_RS09205	COG1301	dicarboxylic acid transport
I6H54_RS09215	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H54_RS09260	COG2175	clavaminate synthase activity
I6H54_RS09270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6H54_RS09270	COG1793	dna ligase
I6H54_RS09275	COG1793	dna ligase
I6H54_RS09280	COG1201	RNA secondary structure unwinding
I6H54_RS09320	COG1802	Transcriptional regulator
I6H54_RS09325	COG0247	lactate metabolic process
I6H54_RS09330	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6H54_RS09335	COG1802	Transcriptional regulator
I6H54_RS09345	COG4774	siderophore transport
I6H54_RS09365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H54_RS09375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H54_RS09380	COG0745	RESPONSE REGULATOR receiver
I6H54_RS09385	COG5002	protein histidine kinase activity
I6H54_RS09390	COG0069	glutamate synthase activity
I6H54_RS09415	COG2205	protein histidine kinase activity
I6H54_RS09415	COG0784	Response regulator, receiver
I6H54_RS09420	COG2199	diguanylate cyclase activity
I6H54_RS09420	COG2200	EAL domain
I6H54_RS09420	COG2203	Gaf domain
I6H54_RS09430	COG2197	response regulator
I6H54_RS09445	COG0840	transmembrane signaling receptor activity
I6H54_RS09530	COG1846	Transcriptional regulator
I6H54_RS09535	COG0697	spore germination
I6H54_RS09545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H54_RS09555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H54_RS09580	COG0864	Transcriptional regulator
I6H54_RS09595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H54_RS09600	COG1522	sequence-specific DNA binding
I6H54_RS09610	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6H54_RS09615	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6H54_RS09625	COG4208	sulfate ABC transporter
I6H54_RS09635	COG1609	Transcriptional regulator
I6H54_RS09655	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6H54_RS09665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6H54_RS09670	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6H54_RS09690	COG2205	protein histidine kinase activity
I6H54_RS09695	COG0745	RESPONSE REGULATOR receiver
I6H54_RS09705	COG4774	siderophore transport
I6H54_RS09705	COG1629	transport
I6H54_RS09715	COG1120	ATPase activity
I6H54_RS09720	COG4592	Periplasmic binding protein
I6H54_RS09725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H54_RS09730	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H54_RS09765	COG0583	DNA-binding transcription factor activity
I6H54_RS09795	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS09805	COG2080	2 iron, 2 sulfur cluster binding
I6H54_RS09810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H54_RS09815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H54_RS09820	COG2011	ABC-type metal ion transport system permease component
I6H54_RS09830	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6H54_RS09845	COG0583	DNA-binding transcription factor activity
I6H54_RS09850	COG1487	ribonuclease activity
I6H54_RS09865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H54_RS09870	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H54_RS09875	COG1129	ABC transporter
I6H54_RS09880	COG1879	ABC-type sugar transport system periplasmic component
I6H54_RS09885	COG1349	DNA-binding transcription factor activity
I6H54_RS09905	COG1396	sequence-specific DNA binding
I6H54_RS09925	COG0529	Catalyzes the synthesis of activated sulfate
I6H54_RS10010	COG0305	Participates in initiation and elongation during chromosome replication
I6H54_RS10025	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6H54_RS10080	COG0740	serine-type endopeptidase activity
I6H54_RS10140	COG1196	nuclear chromosome segregation
I6H54_RS10210	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6H54_RS10215	COG0308	aminopeptidase N
I6H54_RS10225	COG0840	transmembrane signaling receptor activity
I6H54_RS10230	COG2199	diguanylate cyclase activity
I6H54_RS10230	COG2202	Pas domain
I6H54_RS10230	COG2200	EAL domain
I6H54_RS10235	COG1595	DNA-templated transcription, initiation
I6H54_RS10245	COG4774	siderophore transport
I6H54_RS10250	COG1595	DNA-templated transcription, initiation
I6H54_RS10255	COG3712	iron ion homeostasis
I6H54_RS10265	COG1595	DNA-templated transcription, initiation
I6H54_RS10270	COG3712	iron ion homeostasis
I6H54_RS10280	COG1595	DNA-templated transcription, initiation
I6H54_RS10285	COG3712	iron ion homeostasis
I6H54_RS10320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H54_RS10325	COG1136	(ABC) transporter
I6H54_RS10325	COG0577	efflux transmembrane transporter activity
I6H54_RS10350	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H54_RS10365	COG2022	thiamine diphosphate biosynthetic process
I6H54_RS10380	COG0351	phosphomethylpyrimidine kinase
I6H54_RS10395	COG4774	siderophore transport
I6H54_RS10400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H54_RS10410	COG2917	probably involved in intracellular septation
I6H54_RS10415	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H54_RS10420	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6H54_RS10440	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS10455	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6H54_RS10465	COG0411	ABC transporter
I6H54_RS10490	COG0789	Transcriptional regulator
I6H54_RS10495	COG0633	Ferredoxin
I6H54_RS10505	COG1024	Enoyl-CoA hydratase
I6H54_RS10505	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H54_RS10510	COG0183	Belongs to the thiolase family
I6H54_RS10515	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS10555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H54_RS10555	COG1017	nitric oxide dioxygenase activity
I6H54_RS10560	COG0625	glutathione transferase activity
I6H54_RS10585	COG4774	siderophore transport
I6H54_RS10590	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6H54_RS10625	COG3639	organic phosphonate transmembrane transporter activity
I6H54_RS10630	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6H54_RS10635	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6H54_RS10640	COG1620	l-lactate permease
I6H54_RS10645	COG2186	Transcriptional regulator
I6H54_RS10650	COG1304	FMN binding
I6H54_RS10655	COG0277	FAD linked oxidase domain protein
I6H54_RS10660	COG1012	belongs to the aldehyde dehydrogenase family
I6H54_RS10675	COG4772	TonB-dependent receptor
I6H54_RS10690	COG0148	phosphopyruvate hydratase activity
I6H54_RS10705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H54_RS10720	COG2130	NADP-dependent
I6H54_RS10735	COG2814	Major facilitator Superfamily
I6H54_RS10740	COG2814	Major facilitator Superfamily
I6H54_RS10750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H54_RS10760	COG2329	Antibiotic biosynthesis monooxygenase
I6H54_RS10775	COG2132	Multicopper oxidase
I6H54_RS10780	COG2183	response to ionizing radiation
I6H54_RS10810	COG2197	response regulator
I6H54_RS10820	COG0628	permease
I6H54_RS10845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6H54_RS10850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6H54_RS10855	COG0470	DNA polymerase III
I6H54_RS10865	COG0084	hydrolase, TatD family'
I6H54_RS10870	COG0666	response to abiotic stimulus
I6H54_RS10875	COG1132	(ABC) transporter
I6H54_RS10880	COG0823	Involved in the tonB-independent uptake of proteins
I6H54_RS10895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6H54_RS11065	COG0740	serine-type endopeptidase activity
I6H54_RS11145	COG3772	lysozyme
I6H54_RS11155	COG0653	protein targeting
I6H54_RS11270	COG3706	GGDEF domain
I6H54_RS11275	COG0840	transmembrane signaling receptor activity
I6H54_RS11280	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H54_RS11300	COG2366	antibiotic biosynthetic process
I6H54_RS11320	COG2199	diguanylate cyclase activity
I6H54_RS11335	COG3276	selenocysteine insertion sequence binding
I6H54_RS11350	COG2864	formate dehydrogenase
I6H54_RS11355	COG0437	4 iron, 4 sulfur cluster binding
I6H54_RS11365	COG0628	permease
I6H54_RS11370	COG0567	Dehydrogenase, E1 component
I6H54_RS11375	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H54_RS11380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H54_RS11385	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6H54_RS11400	COG1199	ATP-dependent helicase activity
I6H54_RS11415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6H54_RS11420	COG0542	response to heat
I6H54_RS11425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H54_RS11430	COG2925	Exonuclease
I6H54_RS11435	COG0700	Nucleoside recognition
I6H54_RS11440	COG0346	lactoylglutathione lyase activity
I6H54_RS11445	COG4106	trans-aconitate 2-methyltransferase activity
I6H54_RS11460	COG2301	Belongs to the HpcH HpaI aldolase family
I6H54_RS11485	COG2133	pyrroloquinoline quinone binding
I6H54_RS11490	COG0217	transcriptional regulatory protein
I6H54_RS11495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H54_RS11505	COG0433	COG0433 Predicted ATPase
I6H54_RS11510	COG0217	transcriptional regulatory protein
I6H54_RS11515	COG0151	Belongs to the GarS family
I6H54_RS11520	COG0408	coproporphyrinogen oxidase activity
I6H54_RS11525	COG0799	negative regulation of ribosome biogenesis
I6H54_RS11530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6H54_RS11535	COG0424	maF-like protein
I6H54_RS11540	COG1530	ribonuclease E activity
I6H54_RS11575	COG0436	Aminotransferase
I6H54_RS11580	COG0583	DNA-binding transcription factor activity
I6H54_RS11600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6H54_RS11615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H54_RS11630	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H54_RS11640	COG3712	iron ion homeostasis
I6H54_RS11660	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6H54_RS11665	COG0252	asparaginase activity
I6H54_RS11670	COG0563	adenylate kinase activity
I6H54_RS11675	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6H54_RS11680	COG2835	tetraacyldisaccharide 4'-kinase activity
I6H54_RS11685	COG1663	tetraacyldisaccharide 4'-kinase activity
I6H54_RS11690	COG0848	biopolymer transport protein
I6H54_RS11695	COG0811	peptide transport
I6H54_RS11705	COG1570	exodeoxyribonuclease VII activity
I6H54_RS11710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6H54_RS11715	COG0477	Major facilitator Superfamily
I6H54_RS11785	COG1196	nuclear chromosome segregation
I6H54_RS11795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H54_RS11800	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6H54_RS11820	COG0625	glutathione transferase activity
I6H54_RS11835	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6H54_RS11840	COG0183	Belongs to the thiolase family
I6H54_RS11845	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS11855	COG0765	amino acid transport
I6H54_RS11860	COG4597	amino acid ABC transporter
I6H54_RS11865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H54_RS11870	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6H54_RS11875	COG0488	(ABC) transporter
I6H54_RS11885	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS11890	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS11900	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H54_RS11905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H54_RS11915	COG2171	N-acyltransferase activity
I6H54_RS11920	COG0436	Aminotransferase
I6H54_RS11925	COG0840	transmembrane signaling receptor activity
I6H54_RS11930	COG2878	Part of a membrane complex involved in electron transport
I6H54_RS11940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H54_RS11985	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H54_RS12100	COG0457	Tetratricopeptide repeat
I6H54_RS12100	COG0463	Glycosyl transferase, family 2
I6H54_RS12255	COG3437	response regulator, receiver
I6H54_RS12310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H54_RS12315	COG2610	gluconate transmembrane transporter activity
I6H54_RS12335	COG0724	RNA recognition motif
I6H54_RS12350	COG0523	cobalamin synthesis protein
I6H54_RS12355	COG1469	GTP cyclohydrolase I activity
I6H54_RS12360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H54_RS12370	COG0735	belongs to the Fur family
I6H54_RS12380	COG1846	Transcriptional regulator
I6H54_RS12390	COG4774	siderophore transport
I6H54_RS12430	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6H54_RS12455	COG3712	iron ion homeostasis
I6H54_RS12460	COG1595	DNA-templated transcription, initiation
I6H54_RS12475	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS12480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS12495	COG0583	DNA-binding transcription factor activity
I6H54_RS12510	COG0784	Response regulator, receiver
I6H54_RS12510	COG4191	Histidine kinase
I6H54_RS12530	COG0210	DNA helicase
I6H54_RS12575	COG0133	tryptophan synthase activity
I6H54_RS12645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H54_RS12660	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6H54_RS12665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H54_RS12670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6H54_RS12680	COG3135	benzoate transporter
I6H54_RS12705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6H54_RS12715	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H54_RS12735	COG0393	Putative heavy-metal-binding
I6H54_RS12745	COG4206	TonB-dependent receptor
I6H54_RS12755	COG1476	TRANSCRIPTIONal
I6H54_RS12765	COG2207	Transcriptional regulator
I6H54_RS12770	COG2814	Major facilitator Superfamily
I6H54_RS12785	COG4771	TonB-dependent receptor
I6H54_RS12790	COG1113	amino acid transport
I6H54_RS12805	COG2814	Major facilitator Superfamily
I6H54_RS12810	COG1566	PFAM secretion protein HlyD family protein
I6H54_RS12850	COG0840	transmembrane signaling receptor activity
I6H54_RS12855	COG1022	Amp-dependent synthetase and ligase
I6H54_RS12860	COG1802	Transcriptional regulator
I6H54_RS12865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6H54_RS12865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6H54_RS12870	COG1703	isobutyryl-CoA mutase activity
I6H54_RS12875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6H54_RS12880	COG4770	biotin carboxylase activity
I6H54_RS12885	COG0835	chemotaxis
I6H54_RS12885	COG0784	Response regulator, receiver
I6H54_RS12890	COG1609	Transcriptional regulator
I6H54_RS12895	COG3265	gluconokinase activity
I6H54_RS12900	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6H54_RS12905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H54_RS12910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H54_RS12920	COG0800	Aldolase
I6H54_RS12930	COG5001	Diguanylate cyclase
I6H54_RS12935	COG0583	DNA-binding transcription factor activity
I6H54_RS12995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6H54_RS13010	COG1802	Transcriptional regulator
I6H54_RS13015	COG0405	Gamma-glutamyltransferase
I6H54_RS13030	COG0840	transmembrane signaling receptor activity
I6H54_RS13040	COG0583	DNA-binding transcription factor activity
I6H54_RS13050	COG1120	ATPase activity
I6H54_RS13055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H54_RS13125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS13135	COG0583	DNA-binding transcription factor activity
I6H54_RS13285	COG0582	viral genome integration into host DNA
I6H54_RS13305	COG2022	thiamine diphosphate biosynthetic process
I6H54_RS13305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H54_RS13310	COG0456	acetyltransferase
I6H54_RS13355	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6H54_RS13365	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6H54_RS13385	COG0583	DNA-binding transcription factor activity
I6H54_RS13450	COG0741	lytic transglycosylase activity
I6H54_RS13450	COG1196	nuclear chromosome segregation
I6H54_RS13450	COG0739	heme binding
I6H54_RS13480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H54_RS13595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H54_RS13620	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H54_RS13640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6H54_RS13690	COG2894	cell division
I6H54_RS13710	COG2814	Major facilitator Superfamily
I6H54_RS13715	COG0431	NADPH-dependent FMN reductase
I6H54_RS13725	COG2837	iron assimilation
I6H54_RS13755	COG0583	DNA-binding transcription factor activity
I6H54_RS13780	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H54_RS13785	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6H54_RS13790	COG2080	2 iron, 2 sulfur cluster binding
I6H54_RS13795	COG2255	four-way junction helicase activity
I6H54_RS13820	COG5001	Diguanylate cyclase
I6H54_RS13825	COG1597	lipid kinase activity
I6H54_RS13840	COG2205	protein histidine kinase activity
I6H54_RS13850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6H54_RS13870	COG0840	transmembrane signaling receptor activity
I6H54_RS13880	COG1802	Transcriptional regulator
I6H54_RS14105	COG4149	molybdate abc transporter
I6H54_RS14120	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS14135	COG1309	transcriptional regulator
I6H54_RS14140	COG1902	pentaerythritol trinitrate reductase activity
I6H54_RS14145	COG0702	epimerase
I6H54_RS14150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H54_RS14160	COG1764	response to oxidative stress
I6H54_RS14250	COG2985	domain, Protein
I6H54_RS14265	COG0583	DNA-binding transcription factor activity
I6H54_RS14295	COG3781	membrane
I6H54_RS14305	COG0657	acetylesterase activity
I6H54_RS14320	COG1309	transcriptional regulator
I6H54_RS14330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H54_RS14330	COG2010	Cytochrome c
I6H54_RS14335	COG2010	Cytochrome c
I6H54_RS14335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H54_RS14340	COG2080	2 iron, 2 sulfur cluster binding
I6H54_RS14350	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H54_RS14360	COG2197	response regulator
I6H54_RS14370	COG2197	response regulator
I6H54_RS14375	COG0346	lactoylglutathione lyase activity
I6H54_RS14485	COG0740	serine-type endopeptidase activity
I6H54_RS14575	COG5532	Uncharacterized conserved protein (DUF2303)
I6H54_RS14590	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H54_RS14650	COG2032	superoxide dismutase activity
I6H54_RS14660	COG0259	pyridoxamine-phosphate oxidase activity
I6H54_RS14670	COG0583	DNA-binding transcription factor activity
I6H54_RS14705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H54_RS14710	COG1309	transcriptional regulator
I6H54_RS14725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6H54_RS14735	COG1538	Outer membrane efflux protein
I6H54_RS14760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6H54_RS14775	COG0791	NLP P60 protein
I6H54_RS14790	COG0625	glutathione transferase activity
I6H54_RS14815	COG1280	lysine exporter protein (LysE YggA)
I6H54_RS14825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H54_RS14830	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H54_RS14845	COG4566	intracellular signal transduction
I6H54_RS14850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H54_RS14870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6H54_RS14875	COG0167	dihydroorotate dehydrogenase activity
I6H54_RS14895	COG0579	oxidoreductase
I6H54_RS14930	COG0443	Heat shock 70 kDa protein
I6H54_RS14945	COG0822	iron-sulfur transferase activity
I6H54_RS14950	COG1104	cysteine desulfurase activity
I6H54_RS14955	COG1959	2 iron, 2 sulfur cluster binding
I6H54_RS14960	COG0556	nucleotide-excision repair
I6H54_RS14970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS14975	COG5002	protein histidine kinase activity
I6H54_RS14975	COG5001	Diguanylate cyclase
I6H54_RS14985	COG2207	Transcriptional regulator
I6H54_RS14995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H54_RS15010	COG1739	Uncharacterized protein family UPF0029
I6H54_RS15015	COG1473	amidohydrolase
I6H54_RS15050	COG4178	(ABC) transporter
I6H54_RS15070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6H54_RS15100	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6H54_RS15105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H54_RS15110	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6H54_RS15115	COG4181	ATPase activity
I6H54_RS15150	COG0659	secondary active sulfate transmembrane transporter activity
I6H54_RS15155	COG3706	GGDEF domain
I6H54_RS15165	COG1054	Belongs to the UPF0176 family
I6H54_RS15170	COG1414	Transcriptional regulator
I6H54_RS15180	COG0765	amino acid transport
I6H54_RS15185	COG1126	abc transporter atp-binding protein
I6H54_RS15190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H54_RS15205	COG1741	Belongs to the pirin family
I6H54_RS15210	COG0583	DNA-binding transcription factor activity
I6H54_RS15215	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
I6H54_RS15220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H54_RS15225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6H54_RS15245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H54_RS15260	COG0477	Major facilitator Superfamily
I6H54_RS15270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6H54_RS15275	COG1845	cytochrome c oxidase, subunit III
I6H54_RS15280	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6H54_RS15295	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6H54_RS15300	COG0109	protoheme IX farnesyltransferase activity
I6H54_RS15305	COG1612	heme a metabolic process
I6H54_RS15330	COG2226	methyltransferase
I6H54_RS15340	COG3042	response to heat
I6H54_RS15560	COG1783	phage Terminase large subunit
I6H54_RS15595	COG0305	Participates in initiation and elongation during chromosome replication
I6H54_RS15695	COG3723	Recombinational DNA repair protein, rece pathway
I6H54_RS15710	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H54_RS15810	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6H54_RS15820	COG0714	Associated with various cellular activities
I6H54_RS15840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H54_RS15850	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I6H54_RS15860	COG1253	flavin adenine dinucleotide binding
I6H54_RS15885	COG0778	Nitroreductase
I6H54_RS15890	COG0735	belongs to the Fur family
I6H54_RS15900	COG3258	Cytochrome c
I6H54_RS15910	COG0642	Histidine kinase
I6H54_RS15925	COG2814	Major facilitator Superfamily
I6H54_RS15975	COG1538	Outer membrane efflux protein
I6H54_RS15995	COG0564	pseudouridine synthase activity
I6H54_RS16010	COG1802	Transcriptional regulator
I6H54_RS16020	COG3246	L-lysine catabolic process to acetate
I6H54_RS16030	COG2982	Protein involved in outer membrane biogenesis
I6H54_RS16045	COG0587	DNA-directed DNA polymerase activity
I6H54_RS16060	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6H54_RS16080	COG0753	catalase activity
I6H54_RS16090	COG1902	pentaerythritol trinitrate reductase activity
I6H54_RS16090	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H54_RS16100	COG3386	PFAM SMP-30 Gluconolaconase
I6H54_RS16120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H54_RS16125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6H54_RS16130	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS16155	COG0596	Alpha beta hydrolase
I6H54_RS16160	COG0583	DNA-binding transcription factor activity
I6H54_RS16170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H54_RS16180	COG1609	Transcriptional regulator
I6H54_RS16215	COG4191	Histidine kinase
I6H54_RS16220	COG1301	dicarboxylic acid transport
I6H54_RS16240	COG3040	lipid binding
I6H54_RS16270	COG0346	lactoylglutathione lyase activity
I6H54_RS16275	COG0583	DNA-binding transcription factor activity
I6H54_RS16280	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS16295	COG1850	ribulose-bisphosphate carboxylase activity
I6H54_RS16305	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS16310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H54_RS16355	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6H54_RS16360	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6H54_RS16365	COG0662	Cupin 2, conserved barrel domain protein
I6H54_RS16370	COG2207	Transcriptional regulator
I6H54_RS16380	COG0583	DNA-binding transcription factor activity
I6H54_RS16385	COG0833	amino acid
I6H54_RS16405	COG2205	protein histidine kinase activity
I6H54_RS16425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6H54_RS16435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6H54_RS16435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6H54_RS16445	COG0564	pseudouridine synthase activity
I6H54_RS16480	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS16510	COG0753	catalase activity
I6H54_RS16540	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6H54_RS16590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H54_RS16595	COG1414	Transcriptional regulator
I6H54_RS16630	COG0515	serine threonine protein kinase
I6H54_RS16645	COG1944	ATP diphosphatase activity
I6H54_RS16690	COG3459	Glycosyltransferase 36 associated
I6H54_RS16710	COG1272	protein, Hemolysin III
I6H54_RS16735	COG0456	acetyltransferase
I6H54_RS16750	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6H54_RS16770	COG0604	alcohol dehydrogenase
I6H54_RS16790	COG0765	amino acid transport
I6H54_RS16795	COG0765	amino acid transport
I6H54_RS16800	COG2814	Major facilitator Superfamily
I6H54_RS16815	COG3706	GGDEF domain
I6H54_RS16845	COG1971	Probably functions as a manganese efflux pump
I6H54_RS16860	COG0583	DNA-binding transcription factor activity
I6H54_RS16870	COG1280	lysine exporter protein (LysE YggA)
I6H54_RS16875	COG2329	Antibiotic biosynthesis monooxygenase
I6H54_RS16880	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS16880	COG0604	alcohol dehydrogenase
I6H54_RS16880	COG3321	synthase
I6H54_RS16885	COG0583	DNA-binding transcription factor activity
I6H54_RS16890	COG0784	Response regulator, receiver
I6H54_RS16890	COG2205	protein histidine kinase activity
I6H54_RS16895	COG2205	protein histidine kinase activity
I6H54_RS16905	COG2172	sigma factor antagonist activity
I6H54_RS16910	COG1366	Belongs to the anti-sigma-factor antagonist family
I6H54_RS16915	COG1366	Belongs to the anti-sigma-factor antagonist family
I6H54_RS16930	COG4628	conserved protein (DUF2132)
I6H54_RS16935	COG0840	transmembrane signaling receptor activity
I6H54_RS16950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H54_RS16960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H54_RS16970	COG0598	Magnesium transport protein CorA
I6H54_RS16985	COG0583	DNA-binding transcription factor activity
I6H54_RS17000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6H54_RS17005	COG3011	Protein conserved in bacteria
I6H54_RS17025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6H54_RS17030	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS17045	COG2814	Major facilitator Superfamily
I6H54_RS17050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6H54_RS17065	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6H54_RS17070	COG0477	Major facilitator Superfamily
I6H54_RS17075	COG1414	Transcriptional regulator
I6H54_RS17085	COG0667	Aldo Keto reductase
I6H54_RS17125	COG2159	amidohydrolase
I6H54_RS17135	COG2828	Protein conserved in bacteria
I6H54_RS17145	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS17155	COG0583	DNA-binding transcription factor activity
I6H54_RS17185	COG1131	(ABC) transporter
I6H54_RS17200	COG1309	transcriptional regulator
I6H54_RS17235	COG1024	Enoyl-CoA hydratase
I6H54_RS17240	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS17290	COG3209	COG3209 Rhs family protein
I6H54_RS17305	COG1129	ABC transporter
I6H54_RS17335	COG3706	GGDEF domain
I6H54_RS17335	COG4251	negative regulation of phosphorylation
I6H54_RS17335	COG5001	Diguanylate cyclase
I6H54_RS17335	COG2203	Gaf domain
I6H54_RS17345	COG0513	Belongs to the DEAD box helicase family
I6H54_RS17395	COG0789	Transcriptional regulator
I6H54_RS17425	COG2133	pyrroloquinoline quinone binding
I6H54_RS17435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H54_RS17440	COG1794	racemase activity, acting on amino acids and derivatives
I6H54_RS17450	COG2202	Pas domain
I6H54_RS17450	COG2200	EAL domain
I6H54_RS17450	COG2199	diguanylate cyclase activity
I6H54_RS17500	COG0840	transmembrane signaling receptor activity
I6H54_RS17505	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS17515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H54_RS17520	COG1116	anion transmembrane transporter activity
I6H54_RS17545	COG1309	transcriptional regulator
I6H54_RS17575	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6H54_RS17585	COG1959	2 iron, 2 sulfur cluster binding
I6H54_RS17625	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS17650	COG1643	Atp-dependent helicase
I6H54_RS17675	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6H54_RS17685	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS17705	COG1942	4-Oxalocrotonate Tautomerase
I6H54_RS17740	COG2814	Major facilitator Superfamily
I6H54_RS17755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H54_RS17765	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6H54_RS17765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6H54_RS17770	COG2367	Beta-lactamase
I6H54_RS17785	COG1280	lysine exporter protein (LysE YggA)
I6H54_RS17795	COG1063	alcohol dehydrogenase
I6H54_RS17800	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H54_RS17805	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS17810	COG1879	ABC-type sugar transport system periplasmic component
I6H54_RS17815	COG1129	ABC transporter
I6H54_RS17820	COG0698	ribose 5-phosphate isomerase
I6H54_RS17825	COG2376	Dihydroxyacetone kinase
I6H54_RS17830	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6H54_RS17835	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6H54_RS17840	COG4208	sulfate ABC transporter
I6H54_RS17845	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6H54_RS17850	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6H54_RS17865	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6H54_RS17880	COG1464	Belongs to the NlpA lipoprotein family
I6H54_RS17885	COG2011	ABC-type metal ion transport system permease component
I6H54_RS17890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H54_RS17895	COG1122	ATPase activity
I6H54_RS17905	COG1268	BioY protein
I6H54_RS17910	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS17915	COG0183	Belongs to the thiolase family
I6H54_RS17925	COG1464	Belongs to the NlpA lipoprotein family
I6H54_RS17940	COG0277	FAD linked oxidase domain protein
I6H54_RS17940	COG0247	lactate metabolic process
I6H54_RS17945	COG0583	DNA-binding transcription factor activity
I6H54_RS17960	COG0776	regulation of translation
I6H54_RS17965	COG0072	phenylalanine-tRNA ligase activity
I6H54_RS17965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H54_RS17970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6H54_RS17975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H54_RS17980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H54_RS17985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6H54_RS17990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H54_RS18040	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6H54_RS18045	COG0670	Belongs to the BI1 family
I6H54_RS18055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H54_RS18090	COG1116	anion transmembrane transporter activity
I6H54_RS18095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H54_RS18100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H54_RS18105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H54_RS18110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H54_RS18125	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6H54_RS18130	COG2860	membrane
I6H54_RS18135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H54_RS18135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6H54_RS18140	COG4772	TonB-dependent receptor
I6H54_RS18155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H54_RS18160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H54_RS18165	COG1120	ATPase activity
I6H54_RS18185	COG0175	sulfate reduction
I6H54_RS18190	COG0175	sulfate reduction
I6H54_RS18195	COG2895	sulfate adenylyltransferase (ATP) activity
I6H54_RS18200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6H54_RS18205	COG0492	ferredoxin-NADP+ reductase activity
I6H54_RS18215	COG0688	phosphatidylethanolamine metabolic process
I6H54_RS18220	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6H54_RS18465	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6H54_RS18495	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H54_RS18825	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H54_RS18870	COG0582	viral genome integration into host DNA
I6H54_RS18885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6H54_RS18900	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6H54_RS18905	COG0077	Prephenate dehydratase
I6H54_RS18905	COG1605	Chorismate mutase
I6H54_RS18910	COG0287	Prephenate dehydrogenase
I6H54_RS18915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6H54_RS18925	COG0776	regulation of translation
I6H54_RS18935	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6H54_RS18945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H54_RS18945	COG2111	Na H antiporter
I6H54_RS18950	COG1006	Multisubunit Na H antiporter MnhC subunit
I6H54_RS18955	COG0651	ATP synthesis coupled electron transport
I6H54_RS18965	COG2212	antiporter activity
I6H54_RS18975	COG1611	Belongs to the LOG family
I6H54_RS19000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H54_RS19005	COG0824	Thioesterase
I6H54_RS19015	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H54_RS19035	COG0657	acetylesterase activity
I6H54_RS19060	COG4774	siderophore transport
I6H54_RS19125	COG3209	COG3209 Rhs family protein
I6H54_RS19155	COG0347	Belongs to the P(II) protein family
I6H54_RS19220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H54_RS19245	COG0285	dihydrofolate synthase activity
I6H54_RS19250	COG1393	Belongs to the ArsC family
I6H54_RS19260	COG3123	guanosine phosphorylase activity
I6H54_RS19265	COG0137	argininosuccinate synthase activity
I6H54_RS19270	COG0583	DNA-binding transcription factor activity
I6H54_RS19285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H54_RS19290	COG1666	GTP binding
I6H54_RS19295	COG3577	Aspartyl protease
I6H54_RS19305	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS19310	COG3618	amidohydrolase
I6H54_RS19320	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6H54_RS19340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6H54_RS19345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H54_RS19355	COG3655	Transcriptional regulator
I6H54_RS19365	COG0667	Aldo Keto reductase
I6H54_RS19375	COG1113	amino acid transport
I6H54_RS19380	COG1309	transcriptional regulator
I6H54_RS19390	COG3842	ATPase activity
I6H54_RS19425	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6H54_RS19440	COG0826	peptidase U32
I6H54_RS19450	COG0243	molybdopterin cofactor binding
I6H54_RS19455	COG0456	acetyltransferase
I6H54_RS19460	COG2909	trisaccharide binding
I6H54_RS19470	COG0183	Belongs to the thiolase family
I6H54_RS19495	COG1024	Enoyl-CoA hydratase
I6H54_RS19505	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS19510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS19515	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS19525	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS19530	COG1024	Enoyl-CoA hydratase
I6H54_RS19555	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6H54_RS19560	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6H54_RS19565	COG3047	cAMP biosynthetic process
I6H54_RS19570	COG1595	DNA-templated transcription, initiation
I6H54_RS19580	COG4774	siderophore transport
I6H54_RS19595	COG0625	glutathione transferase activity
I6H54_RS19620	COG2354	Protein conserved in bacteria
I6H54_RS19625	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6H54_RS19630	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6H54_RS19635	COG0714	Associated with various cellular activities
I6H54_RS19660	COG0047	phosphoribosylformylglycinamidine synthase activity
I6H54_RS19660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H54_RS19665	COG0024	Methionine aminopeptidase
I6H54_RS19675	COG2233	PERMEase
I6H54_RS19680	COG0242	peptide deformylase activity
I6H54_RS19710	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6H54_RS19715	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6H54_RS19720	COG1414	Transcriptional regulator
I6H54_RS19730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H54_RS19735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H54_RS19740	COG1183	phosphatidylcholine synthase activity
I6H54_RS19745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6H54_RS19750	COG0440	acetolactate synthase activity
I6H54_RS19755	COG0028	Belongs to the TPP enzyme family
I6H54_RS19780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H54_RS19790	COG0347	Belongs to the P(II) protein family
I6H54_RS19805	COG0840	transmembrane signaling receptor activity
I6H54_RS19815	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6H54_RS19845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6H54_RS19850	COG0746	molybdenum cofactor guanylyltransferase activity
I6H54_RS19855	COG0303	'Molybdopterin
I6H54_RS19870	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS19875	COG2175	clavaminate synthase activity
I6H54_RS19890	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6H54_RS19895	COG0328	RNA-DNA hybrid ribonuclease activity
I6H54_RS19900	COG2226	methyltransferase
I6H54_RS19905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H54_RS19910	COG0741	lytic transglycosylase activity
I6H54_RS19910	COG1388	LysM domain
I6H54_RS19925	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H54_RS19930	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6H54_RS19935	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H54_RS19955	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6H54_RS19965	COG0372	Belongs to the citrate synthase family
I6H54_RS19970	COG0254	rRNA binding
I6H54_RS19980	COG0534	Mate efflux family protein
I6H54_RS19995	COG0704	Plays a role in the regulation of phosphate uptake
I6H54_RS20000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H54_RS20005	COG0581	inorganic phosphate transmembrane transporter activity
I6H54_RS20010	COG0573	inorganic phosphate transmembrane transporter activity
I6H54_RS20015	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6H54_RS20020	COG0248	Ppx GppA phosphatase
I6H54_RS20030	COG0248	Ppx GppA phosphatase
I6H54_RS20040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H54_RS20050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H54_RS20055	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6H54_RS20060	COG1534	Rna-binding protein
I6H54_RS20075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H54_RS20080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6H54_RS20085	COG0505	Belongs to the CarA family
I6H54_RS20090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H54_RS20095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H54_RS20100	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6H54_RS20105	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6H54_RS20110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6H54_RS20115	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6H54_RS20130	COG0750	zinc metalloprotease
I6H54_RS20135	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6H54_RS20140	COG0575	Belongs to the CDS family
I6H54_RS20150	COG0233	cytoplasmic translational termination
I6H54_RS20155	COG0528	UMP kinase activity
I6H54_RS20160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6H54_RS20165	COG0052	Belongs to the universal ribosomal protein uS2 family
I6H54_RS20170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H54_RS20175	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H54_RS20175	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H54_RS20180	COG0557	exoribonuclease II activity
I6H54_RS20215	COG0741	lytic transglycosylase activity
I6H54_RS20220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H54_RS20225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H54_RS20230	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6H54_RS20240	COG1125	glycine betaine transport
I6H54_RS20240	COG0517	IMP dehydrogenase activity
I6H54_RS20280	COG1295	ribonuclease BN
I6H54_RS20290	COG0277	FAD linked oxidase domain protein
I6H54_RS20300	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6H54_RS20310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6H54_RS20320	COG3712	iron ion homeostasis
I6H54_RS20340	COG1595	DNA-templated transcription, initiation
I6H54_RS20345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H54_RS20355	COG2814	Major facilitator Superfamily
I6H54_RS20365	COG4336	lyase activity
I6H54_RS20390	COG4948	Mandelate Racemase Muconate Lactonizing
I6H54_RS20405	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS20410	COG0583	DNA-binding transcription factor activity
I6H54_RS20420	COG0402	S-adenosylhomocysteine deaminase activity
I6H54_RS20435	COG0708	Exodeoxyribonuclease III
I6H54_RS20450	COG3852	Histidine kinase
I6H54_RS20460	COG0174	glutamine synthetase
I6H54_RS20465	COG1058	Belongs to the CinA family
I6H54_RS20465	COG1546	Belongs to the CinA family
I6H54_RS20490	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6H54_RS20495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6H54_RS20500	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6H54_RS20505	COG0330	HflC and HflK could
I6H54_RS20510	COG0330	HflC and HflK could
I6H54_RS20515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H54_RS20520	COG1923	regulation of RNA biosynthetic process
I6H54_RS20525	COG1160	GTP binding
I6H54_RS20530	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6H54_RS20540	COG0124	histidyl-tRNA synthetase
I6H54_RS20545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6H54_RS20560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H54_RS20565	COG0105	UTP biosynthetic process
I6H54_RS20570	COG1187	pseudouridine synthase activity
I6H54_RS20575	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H54_RS20580	COG0564	pseudouridine synthase activity
I6H54_RS20590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6H54_RS20595	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6H54_RS20600	COG3321	synthase
I6H54_RS20600	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS20600	COG0604	alcohol dehydrogenase
I6H54_RS20605	COG3706	GGDEF domain
I6H54_RS20610	COG3540	Alkaline phosphatase
I6H54_RS20615	COG0786	glutamate:sodium symporter activity
I6H54_RS20620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H54_RS20625	COG1252	NADH dehydrogenase
I6H54_RS20635	COG0024	Methionine aminopeptidase
I6H54_RS20645	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS20670	COG0358	DNA primase activity
I6H54_RS20675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H54_RS20680	COG2954	triphosphatase activity
I6H54_RS20695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6H54_RS20700	COG1012	belongs to the aldehyde dehydrogenase family
I6H54_RS20705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6H54_RS20710	COG4771	TonB-dependent receptor
I6H54_RS20715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6H54_RS20720	COG1477	protein flavinylation
I6H54_RS20740	COG1595	DNA-templated transcription, initiation
I6H54_RS20745	COG3712	iron ion homeostasis
I6H54_RS20775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H54_RS20790	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H54_RS20805	COG3720	iron ion transport
I6H54_RS20815	COG4206	TonB-dependent receptor
I6H54_RS20835	COG2205	protein histidine kinase activity
I6H54_RS20835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H54_RS20845	COG2271	Major facilitator Superfamily
I6H54_RS20860	COG2308	Evidence 4 Homologs of previously reported genes of
I6H54_RS20875	COG0840	transmembrane signaling receptor activity
I6H54_RS20885	COG0741	lytic transglycosylase activity
I6H54_RS20885	COG1196	nuclear chromosome segregation
I6H54_RS20885	COG0739	heme binding
I6H54_RS20910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H54_RS20915	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6H54_RS20925	COG2850	peptidyl-arginine hydroxylation
I6H54_RS20935	COG1012	belongs to the aldehyde dehydrogenase family
I6H54_RS20940	COG1047	Peptidyl-prolyl cis-trans
I6H54_RS20975	COG0756	dUTP diphosphatase activity
I6H54_RS20985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H54_RS20990	COG0504	CTP synthase activity
I6H54_RS20995	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6H54_RS21005	COG0148	phosphopyruvate hydratase activity
I6H54_RS21010	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6H54_RS21020	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6H54_RS21030	COG2833	Protein of unknown function (DUF455)
I6H54_RS21035	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I6H54_RS21040	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I6H54_RS21045	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS21050	COG4974	Belongs to the 'phage' integrase family
I6H54_RS21070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H54_RS21090	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6H54_RS21100	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6H54_RS21110	COG0586	Pfam SNARE associated Golgi protein
I6H54_RS21120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H54_RS21130	COG1473	amidohydrolase
I6H54_RS21135	COG0583	DNA-binding transcription factor activity
I6H54_RS21150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H54_RS21155	COG0657	acetylesterase activity
I6H54_RS21165	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H54_RS21220	COG2814	Major facilitator Superfamily
I6H54_RS21225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6H54_RS21230	COG1136	(ABC) transporter
I6H54_RS21250	COG0463	Glycosyl transferase, family 2
I6H54_RS21250	COG0457	Tetratricopeptide repeat
I6H54_RS21265	COG3609	addiction module antidote protein, CC2985 family
I6H54_RS21285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H54_RS21310	COG1007	ATP synthesis coupled electron transport
I6H54_RS21325	COG0713	ATP synthesis coupled electron transport
I6H54_RS21335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H54_RS21340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6H54_RS21345	COG1034	ATP synthesis coupled electron transport
I6H54_RS21360	COG0649	NAD binding
I6H54_RS21365	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H54_RS21370	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H54_RS21375	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H54_RS21390	COG0149	triose-phosphate isomerase activity
I6H54_RS21395	COG3321	synthase
I6H54_RS21395	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS21395	COG0604	alcohol dehydrogenase
I6H54_RS21400	COG1185	polyribonucleotide nucleotidyltransferase activity
I6H54_RS21405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6H54_RS21410	COG4970	Tfp pilus assembly protein FimT
I6H54_RS21440	COG4969	Belongs to the N-Me-Phe pilin family
I6H54_RS21470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H54_RS21470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H54_RS21475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H54_RS21490	COG2264	protein methyltransferase activity
I6H54_RS21510	COG0542	response to heat
I6H54_RS21520	COG0697	spore germination
I6H54_RS21525	COG0314	molybdopterin synthase activity
I6H54_RS21540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H54_RS21550	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6H54_RS21555	COG0303	'Molybdopterin
I6H54_RS21560	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6H54_RS21565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6H54_RS21575	COG0436	Aminotransferase
I6H54_RS21585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6H54_RS21590	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6H54_RS21605	COG0359	binds to the 23S rRNA
I6H54_RS21610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H54_RS21620	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H54_RS21625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6H54_RS21630	COG0443	Heat shock 70 kDa protein
I6H54_RS21635	COG0484	heat shock protein binding
I6H54_RS21650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6H54_RS21660	COG0066	3-isopropylmalate dehydratase activity
I6H54_RS21665	COG0473	3-isopropylmalate dehydrogenase activity
I6H54_RS21685	COG0101	tRNA pseudouridine synthase activity
I6H54_RS21690	COG0135	phosphoribosylanthranilate isomerase activity
I6H54_RS21695	COG0133	tryptophan synthase activity
I6H54_RS21700	COG0159	tryptophan synthase activity
I6H54_RS21705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6H54_RS21710	COG0762	integral membrane protein
I6H54_RS21720	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H54_RS21730	COG3706	GGDEF domain
I6H54_RS21730	COG2203	Gaf domain
I6H54_RS21730	COG4251	negative regulation of phosphorylation
I6H54_RS21730	COG5001	Diguanylate cyclase
I6H54_RS21740	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6H54_RS21750	COG3326	Membrane
I6H54_RS21760	COG1472	Belongs to the glycosyl hydrolase 3 family
I6H54_RS21765	COG0736	holo-[acyl-carrier-protein] synthase activity
I6H54_RS21770	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6H54_RS21775	COG1381	Involved in DNA repair and RecF pathway recombination
I6H54_RS21780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6H54_RS21785	COG0571	ribonuclease III activity
I6H54_RS21795	COG0681	Belongs to the peptidase S26 family
I6H54_RS21800	COG0481	GTPase activity
I6H54_RS21805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H54_RS21820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H54_RS21825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H54_RS21830	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS21840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6H54_RS21845	COG0416	fatty acid biosynthetic process
I6H54_RS21850	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6H54_RS21855	COG1399	metal-binding, possibly nucleic acid-binding protein
I6H54_RS21860	COG0424	maF-like protein
I6H54_RS21865	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6H54_RS21870	COG0616	signal peptide processing
I6H54_RS21870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6H54_RS21890	COG1530	ribonuclease E activity
I6H54_RS21895	COG3022	response to hydroperoxide
I6H54_RS21905	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6H54_RS21905	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6H54_RS21910	COG0840	transmembrane signaling receptor activity
I6H54_RS21915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H54_RS21930	COG1595	DNA-templated transcription, initiation
I6H54_RS21945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H54_RS21950	COG1304	FMN binding
I6H54_RS21975	COG1309	transcriptional regulator
I6H54_RS22000	COG0395	ABC-type sugar transport system, permease component
I6H54_RS22015	COG3842	ATPase activity
I6H54_RS22030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H54_RS22060	COG0165	Argininosuccinate lyase
I6H54_RS22065	COG3275	phosphorelay sensor kinase activity
I6H54_RS22070	COG3279	Response regulator of the LytR AlgR family
I6H54_RS22080	COG0251	oxidation-reduction process
I6H54_RS22105	COG0412	Dienelactone hydrolase
I6H54_RS22120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6H54_RS22140	COG0210	DNA helicase
I6H54_RS22145	COG0516	GMP reductase activity
I6H54_RS22165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H54_RS22175	COG2814	Major facilitator Superfamily
I6H54_RS22180	COG3300	MHYT domain
I6H54_RS22180	COG5001	Diguanylate cyclase
I6H54_RS22185	COG0513	Belongs to the DEAD box helicase family
I6H54_RS22190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6H54_RS22195	COG0501	Belongs to the peptidase M48B family
I6H54_RS22200	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6H54_RS22205	COG1162	GTPase activity
I6H54_RS22210	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6H54_RS22215	COG0494	nUDIX hydrolase
I6H54_RS22220	COG0335	large ribosomal subunit rRNA binding
I6H54_RS22225	COG0336	Belongs to the RNA methyltransferase TrmD family
I6H54_RS22230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6H54_RS22235	COG0228	four-way junction DNA binding
I6H54_RS22250	COG0306	phosphate transporter
I6H54_RS22255	COG1392	Phosphate transport regulator
I6H54_RS22280	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6H54_RS22295	COG4221	oxidoreductase activity
I6H54_RS22305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H54_RS22315	COG0840	transmembrane signaling receptor activity
I6H54_RS22320	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6H54_RS22325	COG1674	ftsk spoiiie
I6H54_RS22330	COG0492	ferredoxin-NADP+ reductase activity
I6H54_RS22335	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6H54_RS22340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H54_RS22345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H54_RS22360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H54_RS22360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H54_RS22370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H54_RS22375	COG3132	Protein of unknown function, DUF480
I6H54_RS22380	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS22385	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS22390	COG3781	membrane
I6H54_RS22405	COG2205	protein histidine kinase activity
I6H54_RS22410	COG2205	protein histidine kinase activity
I6H54_RS22425	COG0196	riboflavin kinase activity
I6H54_RS22430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6H54_RS22435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6H54_RS22440	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6H54_RS22455	COG0697	spore germination
I6H54_RS22465	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS22485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H54_RS22500	COG0084	hydrolase, TatD family'
I6H54_RS22510	COG1136	(ABC) transporter
I6H54_RS22525	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS22540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H54_RS22560	COG0840	transmembrane signaling receptor activity
I6H54_RS22565	COG0613	PHP domain protein
I6H54_RS22570	COG0009	L-threonylcarbamoyladenylate synthase
I6H54_RS22580	COG1994	Peptidase M50
I6H54_RS22585	COG0180	Tryptophanyl-tRNA synthetase
I6H54_RS22590	COG0745	RESPONSE REGULATOR receiver
I6H54_RS22615	COG1420	regulation of RNA biosynthetic process
I6H54_RS22620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6H54_RS22625	COG0497	DNA recombination
I6H54_RS22630	COG1660	Displays ATPase and GTPase activities
I6H54_RS22635	COG0745	RESPONSE REGULATOR receiver
I6H54_RS22640	COG2205	protein histidine kinase activity
I6H54_RS22645	COG4452	Inner membrane protein CreD
I6H54_RS22665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H54_RS22670	COG0457	Tetratricopeptide repeat
I6H54_RS22675	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6H54_RS22680	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6H54_RS22690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H54_RS22695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6H54_RS22700	COG0193	aminoacyl-tRNA hydrolase activity
I6H54_RS22705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H54_RS22715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H54_RS22720	COG0444	Belongs to the ABC transporter superfamily
I6H54_RS22725	COG4608	Belongs to the ABC transporter superfamily
I6H54_RS22730	COG0747	negative chemotaxis
I6H54_RS22770	COG0302	gtp cyclohydrolase
I6H54_RS22790	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H54_RS22815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6H54_RS22830	COG2226	methyltransferase
I6H54_RS22850	COG1653	transport
I6H54_RS22860	COG0395	ABC-type sugar transport system, permease component
I6H54_RS22865	COG3842	ATPase activity
I6H54_RS22870	COG0584	glycerophosphoryl diester phosphodiesterase
I6H54_RS22875	COG1511	domain protein
I6H54_RS22875	COG3264	Mechanosensitive ion channel
I6H54_RS22905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6H54_RS22910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H54_RS22915	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H54_RS22920	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6H54_RS22925	COG1253	flavin adenine dinucleotide binding
I6H54_RS22930	COG0741	lytic transglycosylase activity
I6H54_RS22935	COG0442	prolyl-tRNA aminoacylation
I6H54_RS22940	COG0494	nUDIX hydrolase
I6H54_RS22945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6H54_RS22950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6H54_RS22955	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H54_RS22960	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6H54_RS22965	COG0142	geranyltranstransferase activity
I6H54_RS22985	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6H54_RS22995	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6H54_RS23000	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6H54_RS23005	COG0494	nUDIX hydrolase
I6H54_RS23015	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6H54_RS23020	COG0653	protein targeting
I6H54_RS23035	COG2969	positive regulation of protein catabolic process
I6H54_RS23040	COG0625	glutathione transferase activity
I6H54_RS23045	COG2857	Cytochrome c1
I6H54_RS23050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6H54_RS23055	COG0723	plastoquinol--plastocyanin reductase activity
I6H54_RS23060	COG1970	mechanosensitive ion channel activity
I6H54_RS23065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6H54_RS23070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H54_RS23145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H54_RS23160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6H54_RS23170	COG0131	Imidazoleglycerol-phosphate dehydratase
I6H54_RS23175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6H54_RS23190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6H54_RS23200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6H54_RS23205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H54_RS23210	COG5007	Belongs to the BolA IbaG family
I6H54_RS23215	COG0842	Transport permease protein
I6H54_RS23220	COG1131	(ABC) transporter
I6H54_RS23230	COG2854	intermembrane phospholipid transfer
I6H54_RS23240	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6H54_RS23245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6H54_RS23250	COG1127	ABC transporter
I6H54_RS23255	COG1126	abc transporter atp-binding protein
I6H54_RS23260	COG0765	amino acid transport
I6H54_RS23275	COG0438	transferase activity, transferring glycosyl groups
I6H54_RS23305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H54_RS23310	COG0107	imidazoleglycerol-phosphate synthase activity
I6H54_RS23315	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6H54_RS23320	COG0140	phosphoribosyl-ATP diphosphatase activity
I6H54_RS23335	COG0537	adenosine 5'-monophosphoramidase activity
I6H54_RS23340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6H54_RS23345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6H54_RS23350	COG0805	protein transport
I6H54_RS23360	COG0070	glutamate synthase
I6H54_RS23360	COG0067	glutamate synthase
I6H54_RS23360	COG0069	glutamate synthase activity
I6H54_RS23370	COG1414	Transcriptional regulator
I6H54_RS23380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6H54_RS23385	COG0183	Belongs to the thiolase family
I6H54_RS23405	COG1785	Belongs to the alkaline phosphatase family
I6H54_RS23415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H54_RS23430	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6H54_RS23435	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H54_RS23440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H54_RS23480	COG1965	Belongs to the frataxin family
I6H54_RS23495	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6H54_RS23500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6H54_RS23505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6H54_RS23520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H54_RS23520	COG2207	Transcriptional regulator
I6H54_RS23525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H54_RS23530	COG0246	Mannitol dehydrogenase
I6H54_RS23540	COG0395	ABC-type sugar transport system, permease component
I6H54_RS23545	COG1175	transmembrane transport
I6H54_RS23560	COG0166	Belongs to the GPI family
I6H54_RS23565	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6H54_RS23570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6H54_RS23575	COG2267	carboxylic ester hydrolase activity
I6H54_RS23580	COG1560	Kdo2-lipid A biosynthetic process
I6H54_RS23590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H54_RS23600	COG0438	transferase activity, transferring glycosyl groups
I6H54_RS23605	COG0438	transferase activity, transferring glycosyl groups
I6H54_RS23615	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6H54_RS23620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6H54_RS23655	COG0438	transferase activity, transferring glycosyl groups
I6H54_RS23690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H54_RS23695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H54_RS23695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6H54_RS23700	COG1056	cytidyltransferase-related domain
I6H54_RS23700	COG1051	belongs to the nudix hydrolase family
I6H54_RS23710	COG0583	DNA-binding transcription factor activity
I6H54_RS23720	COG2011	ABC-type metal ion transport system permease component
I6H54_RS23740	COG2873	o-acetylhomoserine
I6H54_RS23745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H54_RS23755	COG1116	anion transmembrane transporter activity
I6H54_RS23755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H54_RS23765	COG1132	(ABC) transporter
I6H54_RS23770	COG5265	(ABC) transporter
I6H54_RS23775	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6H54_RS23780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H54_RS23810	COG0583	DNA-binding transcription factor activity
I6H54_RS23820	COG0583	DNA-binding transcription factor activity
I6H54_RS23835	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS23840	COG0523	cobalamin synthesis protein
I6H54_RS23860	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6H54_RS23870	COG0251	oxidation-reduction process
I6H54_RS23905	COG1414	Transcriptional regulator
I6H54_RS23915	COG3284	Transcriptional regulator
I6H54_RS23920	COG1012	belongs to the aldehyde dehydrogenase family
I6H54_RS23930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6H54_RS23935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H54_RS23965	COG1309	transcriptional regulator
I6H54_RS23970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H54_RS23975	COG0459	protein refolding
I6H54_RS23980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H54_RS23985	COG5383	Protein conserved in bacteria
I6H54_RS24000	COG1228	amidohydrolase
I6H54_RS24005	COG4608	Belongs to the ABC transporter superfamily
I6H54_RS24010	COG0444	Belongs to the ABC transporter superfamily
I6H54_RS24015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H54_RS24030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H54_RS24035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H54_RS24040	COG0166	Belongs to the GPI family
I6H54_RS24045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H54_RS24055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H54_RS24065	COG1473	amidohydrolase
I6H54_RS24080	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6H54_RS24085	COG1765	OsmC-like protein
I6H54_RS24090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H54_RS24095	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6H54_RS24165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H54_RS24175	COG0625	glutathione transferase activity
I6H54_RS24205	COG1132	(ABC) transporter
I6H54_RS24210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H54_RS24210	COG0189	ligase activity
I6H54_RS24215	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H54_RS24215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H54_RS24220	COG3045	CreA protein
I6H54_RS24225	COG0583	DNA-binding transcription factor activity
I6H54_RS24260	COG0443	Heat shock 70 kDa protein
I6H54_RS24265	COG0443	Heat shock 70 kDa protein
I6H54_RS24285	COG0307	riboflavin synthase, alpha
I6H54_RS24295	COG0737	Belongs to the 5'-nucleotidase family
I6H54_RS24305	COG4770	biotin carboxylase activity
I6H54_RS24310	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6H54_RS24315	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6H54_RS24320	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6H54_RS24350	COG1802	Transcriptional regulator
I6H54_RS24355	COG2259	Doxx family
I6H54_RS24365	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6H54_RS24375	COG0488	(ABC) transporter
I6H54_RS24380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H54_RS24385	COG0745	RESPONSE REGULATOR receiver
I6H54_RS24415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H54_RS24420	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6H54_RS24425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H54_RS24435	COG4771	TonB-dependent receptor
I6H54_RS24445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H54_RS24475	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I6H54_RS24490	COG1397	ADP-ribosylglycohydrolase
I6H54_RS24520	COG0277	FAD linked oxidase domain protein
I6H54_RS24525	COG0436	Aminotransferase
I6H54_RS24530	COG0765	amino acid transport
I6H54_RS24535	COG0765	amino acid transport
I6H54_RS24540	COG1126	abc transporter atp-binding protein
I6H54_RS24580	COG4221	oxidoreductase activity
I6H54_RS24605	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I6H54_RS24620	COG1914	H( )-stimulated, divalent metal cation uptake system
I6H54_RS24630	COG1045	serine acetyltransferase
I6H54_RS24640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H54_RS24645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H54_RS24660	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS24665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H54_RS24670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6H54_RS24680	COG0583	DNA-binding transcription factor activity
I6H54_RS24730	COG4555	ABC transporter
I6H54_RS24735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6H54_RS24735	COG0475	glutathione-regulated potassium exporter activity
I6H54_RS24740	COG0346	lactoylglutathione lyase activity
I6H54_RS24785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H54_RS24790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H54_RS24815	COG2207	Transcriptional regulator
I6H54_RS24820	COG2223	nitrite transmembrane transporter activity
I6H54_RS24825	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS24830	COG0129	dihydroxy-acid dehydratase activity
I6H54_RS24860	COG1285	pathogenesis
I6H54_RS24865	COG0038	chloride channel
I6H54_RS24880	COG2875	Belongs to the precorrin methyltransferase family
I6H54_RS24895	COG2099	Precorrin-6x reductase
I6H54_RS24920	COG0840	transmembrane signaling receptor activity
I6H54_RS24925	COG3712	iron ion homeostasis
I6H54_RS24955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H54_RS24960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H54_RS24975	COG0583	DNA-binding transcription factor activity
I6H54_RS24995	COG3800	Transcriptional regulator
I6H54_RS24995	COG1396	sequence-specific DNA binding
I6H54_RS25035	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6H54_RS25060	COG2318	DinB family
I6H54_RS25075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H54_RS25105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6H54_RS25120	COG1309	transcriptional regulator
I6H54_RS25130	COG1595	DNA-templated transcription, initiation
I6H54_RS25135	COG3712	iron ion homeostasis
I6H54_RS25145	COG1595	DNA-templated transcription, initiation
I6H54_RS25150	COG3712	iron ion homeostasis
I6H54_RS25155	COG4774	siderophore transport
I6H54_RS25160	COG4774	siderophore transport
I6H54_RS25180	COG1522	sequence-specific DNA binding
I6H54_RS25185	COG3706	GGDEF domain
I6H54_RS25195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H54_RS25200	COG0583	DNA-binding transcription factor activity
I6H54_RS25205	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6H54_RS25210	COG0739	heme binding
I6H54_RS25215	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6H54_RS25220	COG2252	PERMEase
I6H54_RS25225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H54_RS25235	COG2814	Major facilitator Superfamily
I6H54_RS25240	COG0316	Belongs to the HesB IscA family
I6H54_RS25245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6H54_RS25250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H54_RS25255	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6H54_RS25260	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6H54_RS25265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6H54_RS25275	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6H54_RS25280	COG0745	RESPONSE REGULATOR receiver
I6H54_RS25285	COG2205	protein histidine kinase activity
I6H54_RS25295	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6H54_RS25305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6H54_RS25320	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6H54_RS25340	COG2076	Multidrug Resistance protein
I6H54_RS25365	COG3121	Chaperone
I6H54_RS25370	COG3188	usher protein
I6H54_RS25380	COG3121	Chaperone
I6H54_RS25385	COG3188	usher protein
I6H54_RS25405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H54_RS25410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H54_RS25420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H54_RS25425	COG1414	Transcriptional regulator
I6H54_RS25430	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6H54_RS25435	COG0477	Major facilitator Superfamily
I6H54_RS25440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6H54_RS25450	COG0583	DNA-binding transcription factor activity
I6H54_RS25455	COG2814	Major facilitator Superfamily
I6H54_RS25460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H54_RS25470	COG0477	Major facilitator Superfamily
I6H54_RS25475	COG3162	membrane
I6H54_RS25480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H54_RS25520	COG0583	DNA-binding transcription factor activity
I6H54_RS25525	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H54_RS25530	COG3246	L-lysine catabolic process to acetate
I6H54_RS25540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H54_RS25555	COG1024	Enoyl-CoA hydratase
I6H54_RS25560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6H54_RS25565	COG0025	NhaP-type Na H and K H
I6H54_RS25570	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS25585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H54_RS25600	COG0784	Response regulator, receiver
I6H54_RS25600	COG2205	protein histidine kinase activity
I6H54_RS25600	COG2198	Histidine kinase
I6H54_RS25605	COG3012	SEC-C Motif Domain Protein
I6H54_RS25620	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS25635	COG0183	Belongs to the thiolase family
I6H54_RS25640	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6H54_RS25645	COG0288	reversible hydration of carbon dioxide
I6H54_RS25650	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS25720	COG0488	(ABC) transporter
I6H54_RS25725	COG2201	protein-glutamate methylesterase activity
I6H54_RS25730	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6H54_RS25735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6H54_RS25740	COG0835	chemotaxis
I6H54_RS25745	COG0643	Histidine kinase
I6H54_RS25745	COG2198	Histidine kinase
I6H54_RS25750	COG0745	RESPONSE REGULATOR receiver
I6H54_RS25765	COG2197	response regulator
I6H54_RS25780	COG1338	Plays a role in the flagellum-specific transport system
I6H54_RS25790	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6H54_RS25815	COG1157	protein secretion by the type III secretion system
I6H54_RS25850	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6H54_RS25855	COG1815	bacterial-type flagellum-dependent cell motility
I6H54_RS25860	COG1558	bacterial-type flagellum-dependent cell motility
I6H54_RS25865	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6H54_RS25880	COG4786	Flagellar basal body rod
I6H54_RS25885	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6H54_RS25890	COG1706	bacterial-type flagellum-dependent cell motility
I6H54_RS25905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6H54_RS25925	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6H54_RS25930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6H54_RS25935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6H54_RS25945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6H54_RS25950	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS25955	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS25990	COG0457	Tetratricopeptide repeat
I6H54_RS25990	COG0463	Glycosyl transferase, family 2
I6H54_RS26005	COG0745	RESPONSE REGULATOR receiver
I6H54_RS26010	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6H54_RS26020	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6H54_RS26035	COG1191	sigma factor activity
I6H54_RS26040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H54_RS26050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H54_RS26075	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS26090	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6H54_RS26095	COG1832	CoA-binding protein
I6H54_RS26110	COG1414	Transcriptional regulator
I6H54_RS26165	COG2050	protein possibly involved in aromatic compounds catabolism
I6H54_RS26170	COG1024	Enoyl-CoA hydratase
I6H54_RS26180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6H54_RS26185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H54_RS26215	COG0679	Auxin Efflux Carrier
I6H54_RS26240	COG0210	DNA helicase
I6H54_RS26265	COG0343	queuine tRNA-ribosyltransferase activity
I6H54_RS26325	COG0204	Acyl-transferase
I6H54_RS26325	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS26345	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS26350	COG2072	flavoprotein involved in K transport
I6H54_RS26370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H54_RS26395	COG0625	glutathione transferase activity
I6H54_RS26400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H54_RS26405	COG1074	ATP-dependent DNA helicase activity
I6H54_RS26410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6H54_RS26420	COG1959	2 iron, 2 sulfur cluster binding
I6H54_RS26440	COG2204	response regulator
I6H54_RS26445	COG5000	phosphorelay sensor kinase activity
I6H54_RS26455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H54_RS26455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H54_RS26465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H54_RS26470	COG0085	RNA polymerase activity
I6H54_RS26475	COG0222	ribosome binding
I6H54_RS26480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H54_RS26485	COG0081	regulation of translation
I6H54_RS26490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6H54_RS26500	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H54_RS26510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H54_RS26540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H54_RS26590	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6H54_RS26595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6H54_RS26600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6H54_RS26605	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6H54_RS26610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H54_RS26615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6H54_RS26625	COG0356	it plays a direct role in the translocation of protons across the membrane
I6H54_RS26635	COG2921	Belongs to the UPF0250 family
I6H54_RS26640	COG0321	lipoyl(octanoyl) transferase activity
I6H54_RS26645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6H54_RS26650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H54_RS26655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H54_RS26670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H54_RS26675	COG3909	cytochrome
I6H54_RS26690	COG0678	peroxiredoxin activity
I6H54_RS26695	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6H54_RS26700	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H54_RS26705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6H54_RS26710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H54_RS26715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H54_RS26720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H54_RS26725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H54_RS26730	COG0089	rRNA binding
I6H54_RS26735	COG0088	Forms part of the polypeptide exit tunnel
I6H54_RS26740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H54_RS26745	COG0051	transcription antitermination factor activity, RNA binding
I6H54_RS26750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H54_RS26755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H54_RS26760	COG0049	tRNA binding
I6H54_RS26765	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H54_RS26770	COG1686	Belongs to the peptidase S11 family
I6H54_RS26775	COG2945	thiolester hydrolase activity
I6H54_RS26780	COG3411	Ferredoxin
I6H54_RS26790	COG1981	membrane
I6H54_RS26800	COG0598	Magnesium transport protein CorA
I6H54_RS26805	COG4585	Histidine kinase
I6H54_RS26810	COG2197	response regulator
I6H54_RS26840	COG0412	Dienelactone hydrolase
I6H54_RS26845	COG2095	MarC family integral membrane protein
I6H54_RS26850	COG2703	oxygen carrier activity
I6H54_RS26860	COG3237	CsbD-like
I6H54_RS26880	COG1127	ABC transporter
I6H54_RS26885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6H54_RS26895	COG0583	DNA-binding transcription factor activity
I6H54_RS26915	COG0765	amino acid transport
I6H54_RS26925	COG0768	penicillin binding
I6H54_RS26935	COG1792	Involved in formation and maintenance of cell shape
I6H54_RS26940	COG1077	Cell shape determining protein MreB Mrl
I6H54_RS26945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H54_RS26950	COG0154	amidase activity
I6H54_RS26955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H54_RS26970	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H54_RS26970	COG0617	tRNA 3'-terminal CCA addition
I6H54_RS26970	COG0517	IMP dehydrogenase activity
I6H54_RS26975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H54_RS27010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6H54_RS27015	COG0708	Exodeoxyribonuclease III
I6H54_RS27040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H54_RS27065	COG2211	Major facilitator Superfamily
I6H54_RS27075	COG2205	protein histidine kinase activity
I6H54_RS27095	COG0583	DNA-binding transcription factor activity
I6H54_RS27100	COG2814	Major facilitator Superfamily
I6H54_RS27115	COG1216	Glycosyl transferase, family 2
I6H54_RS27115	COG1442	glycosyl transferase family 8
I6H54_RS27165	COG1846	Transcriptional regulator
I6H54_RS27170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6H54_RS27195	COG0247	lactate metabolic process
I6H54_RS27205	COG0277	FAD linked oxidase domain protein
I6H54_RS27215	COG0004	ammonium transporteR
I6H54_RS27220	COG0347	Belongs to the P(II) protein family
I6H54_RS27235	COG3119	arylsulfatase activity
I6H54_RS27240	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS27250	COG2267	carboxylic ester hydrolase activity
I6H54_RS27255	COG1012	belongs to the aldehyde dehydrogenase family
I6H54_RS27265	COG4948	Mandelate Racemase Muconate Lactonizing
I6H54_RS27270	COG2271	Major facilitator Superfamily
I6H54_RS27285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H54_RS27305	COG0606	chelatase, subunit chli
I6H54_RS27310	COG0583	DNA-binding transcription factor activity
I6H54_RS27330	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS27345	COG0583	DNA-binding transcription factor activity
I6H54_RS27365	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS27370	COG0583	DNA-binding transcription factor activity
I6H54_RS27380	COG1414	Transcriptional regulator
I6H54_RS27385	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS27400	COG3549	Plasmid maintenance system killer
I6H54_RS27430	COG0583	DNA-binding transcription factor activity
I6H54_RS27440	COG2721	sulfolactate sulfo-lyase activity
I6H54_RS27445	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS27450	COG4948	Mandelate Racemase Muconate Lactonizing
I6H54_RS27455	COG2186	Transcriptional regulator
I6H54_RS27460	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS27465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H54_RS27470	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS27475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H54_RS27485	COG1012	belongs to the aldehyde dehydrogenase family
I6H54_RS27510	COG1346	cytolysis
I6H54_RS27520	COG0583	DNA-binding transcription factor activity
I6H54_RS27535	COG2824	Alkylphosphonate utilization operon protein PhnA
I6H54_RS27555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H54_RS27565	COG1301	dicarboxylic acid transport
I6H54_RS27575	COG0584	glycerophosphoryl diester phosphodiesterase
I6H54_RS27580	COG0646	methionine synthase
I6H54_RS27580	COG1410	methionine synthase
I6H54_RS27585	COG2186	Transcriptional regulator
I6H54_RS27595	COG0765	amino acid transport
I6H54_RS27600	COG0765	amino acid transport
I6H54_RS27605	COG1126	abc transporter atp-binding protein
I6H54_RS27645	COG0784	Response regulator, receiver
I6H54_RS27645	COG2198	Histidine kinase
I6H54_RS27645	COG2205	protein histidine kinase activity
I6H54_RS27675	COG2326	polyphosphate kinase activity
I6H54_RS27680	COG3971	2-oxopent-4-enoate hydratase activity
I6H54_RS27685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H54_RS27695	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS27740	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS27745	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6H54_RS27750	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS27755	COG2030	dehydratase
I6H54_RS27760	COG1024	Enoyl-CoA hydratase
I6H54_RS27765	COG0427	acetyl-CoA hydrolase
I6H54_RS27770	COG0183	Belongs to the thiolase family
I6H54_RS27790	COG0583	DNA-binding transcription factor activity
I6H54_RS27800	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS27805	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS27815	COG0154	amidase activity
I6H54_RS27820	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6H54_RS27855	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS27865	COG0583	DNA-binding transcription factor activity
I6H54_RS27870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS27900	COG3949	Membrane
I6H54_RS27910	COG1538	Outer membrane efflux protein
I6H54_RS27920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H54_RS27950	COG0789	Transcriptional regulator
I6H54_RS27965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6H54_RS27970	COG0277	FAD linked oxidase domain protein
I6H54_RS27975	COG1228	amidohydrolase
I6H54_RS27985	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6H54_RS27990	COG2986	histidine ammonia-lyase
I6H54_RS27995	COG2188	Transcriptional regulator
I6H54_RS28005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H54_RS28020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS28050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6H54_RS28065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6H54_RS28115	COG0745	RESPONSE REGULATOR receiver
I6H54_RS28120	COG5002	protein histidine kinase activity
I6H54_RS28130	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS28140	COG2375	cellular response to nickel ion
I6H54_RS28150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H54_RS28160	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6H54_RS28200	COG1012	belongs to the aldehyde dehydrogenase family
I6H54_RS28205	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS28225	COG3971	2-oxopent-4-enoate hydratase activity
I6H54_RS28240	COG1846	Transcriptional regulator
I6H54_RS28245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H54_RS28245	COG1199	ATP-dependent helicase activity
I6H54_RS28250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H54_RS28280	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6H54_RS28290	COG0850	regulation of cytokinetic process
I6H54_RS28300	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS28305	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS28310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6H54_RS28315	COG2233	PERMEase
I6H54_RS28325	COG2050	protein possibly involved in aromatic compounds catabolism
I6H54_RS28370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H54_RS28370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H54_RS28395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H54_RS28400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H54_RS28410	COG2096	Adenosyltransferase
I6H54_RS28420	COG0277	FAD linked oxidase domain protein
I6H54_RS28430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS28490	COG1475	DNA binding
I6H54_RS28500	COG1192	Involved in chromosome partitioning
I6H54_RS28505	COG1280	lysine exporter protein (LysE YggA)
I6H54_RS28510	COG0357	Ribosomal RNA small subunit methyltransferase G
I6H54_RS28515	COG0445	tRNA wobble uridine modification
I6H54_RS28530	COG1902	pentaerythritol trinitrate reductase activity
I6H54_RS28545	COG0789	Transcriptional regulator
I6H54_RS28550	COG1309	transcriptional regulator
I6H54_RS28580	COG1022	Amp-dependent synthetase and ligase
I6H54_RS28585	COG1024	Enoyl-CoA hydratase
I6H54_RS28590	COG0183	Belongs to the thiolase family
I6H54_RS28595	COG2974	May be involved in recombination
I6H54_RS28610	COG1199	ATP-dependent helicase activity
I6H54_RS28640	COG2205	protein histidine kinase activity
I6H54_RS28680	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H54_RS28685	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6H54_RS28695	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H54_RS28700	COG0706	membrane insertase activity
I6H54_RS28705	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H54_RS28720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H54_RS28725	COG0517	IMP dehydrogenase activity
I6H54_RS28725	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6H54_RS28740	COG0300	oxidoreductase activity
I6H54_RS28745	COG0724	RNA recognition motif
I6H54_RS28750	COG0724	RNA recognition motif
I6H54_RS28755	COG2119	membrane
I6H54_RS28760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H54_RS28765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H54_RS28765	COG2813	Specifically methylates the guanine in position
I6H54_RS28770	COG0584	glycerophosphoryl diester phosphodiesterase
I6H54_RS28775	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6H54_RS28795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H54_RS28805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6H54_RS28810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H54_RS28815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H54_RS28830	COG0280	phosphate acetyltransferase
I6H54_RS28830	COG0281	malic enzyme
I6H54_RS28855	COG4177	L-phenylalanine transmembrane transporter activity
I6H54_RS28860	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6H54_RS28875	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS28895	COG2205	protein histidine kinase activity
I6H54_RS28895	COG0784	Response regulator, receiver
I6H54_RS28895	COG2198	Histidine kinase
I6H54_RS28900	COG3437	response regulator, receiver
I6H54_RS28915	COG1595	DNA-templated transcription, initiation
I6H54_RS28930	COG0735	belongs to the Fur family
I6H54_RS28935	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6H54_RS28940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6H54_RS28955	COG0668	transmembrane transport
I6H54_RS28960	COG0495	leucyl-tRNA aminoacylation
I6H54_RS28980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6H54_RS28985	COG0569	domain protein
I6H54_RS28990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H54_RS29000	COG3158	transport of potassium into the cell
I6H54_RS29005	COG3135	benzoate transporter
I6H54_RS29010	COG0189	ligase activity
I6H54_RS29060	COG0121	glutamine amidotransferase
I6H54_RS29070	COG1942	4-Oxalocrotonate Tautomerase
I6H54_RS29080	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6H54_RS29100	COG0018	arginyl-trna synthetase
I6H54_RS29105	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6H54_RS29110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H54_RS29115	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6H54_RS29120	COG1137	ATPase activity
I6H54_RS29125	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6H54_RS29130	COG4650	regulator
I6H54_RS29145	COG1690	Belongs to the RtcB family
I6H54_RS29150	COG3541	Predicted nucleotidyltransferase
I6H54_RS29155	COG0430	RNA-3'-phosphate cyclase activity
I6H54_RS29160	COG0010	Belongs to the arginase family
I6H54_RS29165	COG2423	ornithine cyclodeaminase activity
I6H54_RS29180	COG2076	Multidrug Resistance protein
I6H54_RS29200	COG0456	acetyltransferase
I6H54_RS29230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS29245	COG0183	Belongs to the thiolase family
I6H54_RS29255	COG1960	acyl-CoA dehydrogenase activity
I6H54_RS29300	COG0653	protein targeting
I6H54_RS29310	COG1546	Belongs to the CinA family
I6H54_RS29315	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6H54_RS29330	COG0583	DNA-binding transcription factor activity
I6H54_RS29355	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6H54_RS29370	COG2967	ApaG domain
I6H54_RS29375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H54_RS29400	COG3958	Transketolase
I6H54_RS29405	COG3959	Transketolase, thiamine diphosphate binding domain
I6H54_RS29410	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H54_RS29420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H54_RS29425	COG1028	Short-chain dehydrogenase reductase Sdr
I6H54_RS29430	COG0583	DNA-binding transcription factor activity
I6H54_RS29440	COG2205	protein histidine kinase activity
I6H54_RS29440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H54_RS29445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H54_RS29450	COG3437	response regulator, receiver
I6H54_RS29450	COG0784	Response regulator, receiver
I6H54_RS29455	COG0745	RESPONSE REGULATOR receiver
I6H54_RS29465	COG0840	transmembrane signaling receptor activity
I6H54_RS29470	COG0835	chemotaxis
I6H54_RS29475	COG0840	transmembrane signaling receptor activity
I6H54_RS29480	COG0546	phosphoglycolate phosphatase activity
I6H54_RS29485	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6H54_RS29505	COG0642	Histidine kinase
I6H54_RS29520	COG3621	Patatin-like phospholipase
I6H54_RS29565	COG0842	Transport permease protein
I6H54_RS29570	COG0842	Transport permease protein
I6H54_RS29570	COG1129	ABC transporter
I6H54_RS29575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H54_RS29585	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6H54_RS29625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6H54_RS29630	COG0134	indole-3-glycerol-phosphate synthase activity
I6H54_RS29645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6H54_RS29650	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6H54_RS29680	COG0583	DNA-binding transcription factor activity
I6H54_RS29695	COG1072	(Pantothenic acid kinase))
I6H54_RS29705	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H54_RS29710	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H54_RS29715	COG1129	ABC transporter
I6H54_RS29750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6H54_RS29765	COG1053	succinate dehydrogenase
I6H54_RS29765	COG3976	FMN-binding domain protein
I6H54_RS29785	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS29795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H54_RS29805	COG1024	Enoyl-CoA hydratase
I6H54_RS29810	COG0583	DNA-binding transcription factor activity
I6H54_RS29815	COG0482	sulfurtransferase activity
I6H54_RS29825	COG4585	Histidine kinase
I6H54_RS29835	COG1309	transcriptional regulator
I6H54_RS29840	COG1012	belongs to the aldehyde dehydrogenase family
I6H54_RS29850	COG3396	Phenylacetate-CoA oxygenase
I6H54_RS29855	COG3460	Phenylacetate-CoA oxygenase
I6H54_RS29860	COG3396	Phenylacetate-CoA oxygenase
I6H54_RS29865	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H54_RS29870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H54_RS29885	COG0659	secondary active sulfate transmembrane transporter activity
I6H54_RS29900	COG0629	single-stranded DNA binding
I6H54_RS29905	COG2814	Major facilitator Superfamily
I6H54_RS29930	COG0583	DNA-binding transcription factor activity
I6H54_RS29935	COG0284	orotidine-5'-phosphate decarboxylase activity
I6H54_RS29955	COG0126	phosphoglycerate kinase activity
I6H54_RS29970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H54_RS29980	COG0242	peptide deformylase activity
I6H54_RS29990	COG0758	DNA mediated transformation
I6H54_RS30000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H54_RS30005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H54_RS30010	COG1862	Preprotein translocase
I6H54_RS30020	COG1522	sequence-specific DNA binding
I6H54_RS30025	COG2814	Major facilitator Superfamily
I6H54_RS30030	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6H54_RS30040	COG2885	chlorophyll binding
I6H54_RS30070	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6H54_RS30075	COG0625	glutathione transferase activity
I6H54_RS30110	COG0861	Integral membrane protein TerC family
I6H54_RS30120	COG1950	PFAM Membrane protein of
I6H54_RS30125	COG4783	chaperone-mediated protein folding
I6H54_RS30130	COG0315	cyclic pyranopterin monophosphate synthase activity
I6H54_RS30140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6H54_RS30140	COG2755	lipolytic protein G-D-S-L family
I6H54_RS30160	COG0438	transferase activity, transferring glycosyl groups
I6H54_RS30175	COG0438	transferase activity, transferring glycosyl groups
I6H54_RS30185	COG1216	Glycosyl transferase, family 2
I6H54_RS30205	COG0631	protein serine/threonine phosphatase activity
I6H54_RS30210	COG0861	Integral membrane protein TerC family
I6H54_RS30215	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6H54_RS30220	COG0045	succinate-CoA ligase (ADP-forming) activity
I6H54_RS30225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6H54_RS30240	COG2137	regulation of response to DNA damage stimulus
I6H54_RS30245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H54_RS30260	COG0642	Histidine kinase
I6H54_RS30300	COG2365	Tyrosine phosphatase family
I6H54_RS30305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H54_RS30315	COG0386	Belongs to the glutathione peroxidase family
I6H54_RS30340	COG0419	ATPase involved in DNA repair
I6H54_RS30345	COG0420	3'-5' exonuclease activity
I6H54_RS30360	COG3148	PFAM DTW domain containing protein
I6H54_RS30365	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6H54_RS30365	COG2755	lipolytic protein G-D-S-L family
I6H54_RS30375	COG3550	peptidyl-serine autophosphorylation
I6H54_RS30380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6H54_RS30395	COG0625	glutathione transferase activity
I6H54_RS30410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H54_RS30415	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS30420	COG0583	DNA-binding transcription factor activity
I6H54_RS30440	COG0583	DNA-binding transcription factor activity
I6H54_RS30445	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6H54_RS30475	COG0640	Transcriptional regulator
I6H54_RS30480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H54_RS30485	COG0006	proline dipeptidase activity
I6H54_RS30500	COG0318	PFAM AMP-dependent synthetase and ligase
I6H54_RS30510	COG0469	pyruvate kinase activity
I6H54_RS30515	COG0671	phosphoesterase, PA-phosphatase related
I6H54_RS30545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6H54_RS30550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6H54_RS30555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6H54_RS30560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H54_RS30565	COG3181	Tripartite tricarboxylate transporter family receptor
I6H54_RS30570	COG1473	amidohydrolase
I6H54_RS30575	COG0583	DNA-binding transcription factor activity
I6H54_RS30580	COG0656	L-ascorbic acid biosynthetic process
I6H54_RS30595	COG1522	sequence-specific DNA binding
I6H54_RS30600	COG1309	transcriptional regulator
I6H54_RS30605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6H54_RS30625	COG1414	Transcriptional regulator
I6H54_RS30630	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6H54_RS30650	COG1414	Transcriptional regulator
I6H54_RS30665	COG1012	belongs to the aldehyde dehydrogenase family
I6H54_RS30705	COG0583	DNA-binding transcription factor activity
I6H54_RS30720	COG0251	oxidation-reduction process
I6H54_RS30725	COG0598	Magnesium transport protein CorA
I6H54_RS30735	COG0456	acetyltransferase
I6H54_RS30740	COG1214	PFAM Peptidase M22, glycoprotease
I6H54_RS30780	COG3718	enzyme involved in inositol metabolism
I6H54_RS30785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H54_RS30795	COG0009	L-threonylcarbamoyladenylate synthase
I6H54_RS30800	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6H54_RS30805	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6H54_RS30815	COG3842	ATPase activity
I6H54_RS30820	COG3118	belongs to the thioredoxin family
I6H54_RS30830	COG0583	DNA-binding transcription factor activity
I6H54_RS30845	COG0693	protein deglycase activity
I6H54_RS30850	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6H54_RS30855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6H54_RS30865	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6H54_RS30880	COG4607	ABC-type enterochelin transport system periplasmic component
I6H54_RS30885	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H54_RS30890	COG4605	iron ion homeostasis
I6H54_RS30895	COG4604	ABC transporter, ATP-binding protein
I6H54_RS30900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)