locus-tag	class	description
BI380_RS00125	COG2916	Histone family protein nucleoid-structuring protein H-NS
BI380_RS00170	COG1272	protein, Hemolysin III
BI380_RS00195	COG2916	Histone family protein nucleoid-structuring protein H-NS
BI380_RS00210	COG5532	Uncharacterized conserved protein (DUF2303)
BI380_RS00230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI380_RS00415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BI380_RS00420	COG0688	phosphatidylethanolamine metabolic process
BI380_RS00430	COG0492	ferredoxin-NADP+ reductase activity
BI380_RS00435	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BI380_RS00440	COG2895	sulfate adenylyltransferase (ATP) activity
BI380_RS00450	COG0175	sulfate reduction
BI380_RS00470	COG1120	ATPase activity
BI380_RS00475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI380_RS00490	COG4772	TonB-dependent receptor
BI380_RS00495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI380_RS00495	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BI380_RS00500	COG2860	membrane
BI380_RS00505	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BI380_RS00515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI380_RS00520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI380_RS00525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI380_RS00530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI380_RS00535	COG1116	anion transmembrane transporter activity
BI380_RS00570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI380_RS00580	COG0670	Belongs to the BI1 family
BI380_RS00585	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BI380_RS00635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BI380_RS00640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BI380_RS00645	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BI380_RS00650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BI380_RS00655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BI380_RS00660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI380_RS00660	COG0072	phenylalanine-tRNA ligase activity
BI380_RS00665	COG0776	regulation of translation
BI380_RS00680	COG0583	DNA-binding transcription factor activity
BI380_RS00685	COG0277	FAD linked oxidase domain protein
BI380_RS00685	COG0247	lactate metabolic process
BI380_RS00700	COG1464	Belongs to the NlpA lipoprotein family
BI380_RS00710	COG0183	Belongs to the thiolase family
BI380_RS00715	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS00720	COG1268	BioY protein
BI380_RS00730	COG1122	ATPase activity
BI380_RS00735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI380_RS00740	COG2011	ABC-type metal ion transport system permease component
BI380_RS00745	COG1464	Belongs to the NlpA lipoprotein family
BI380_RS00765	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BI380_RS00780	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BI380_RS00785	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BI380_RS00790	COG4208	sulfate ABC transporter
BI380_RS00795	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BI380_RS00800	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BI380_RS00805	COG2376	Dihydroxyacetone kinase
BI380_RS00810	COG0698	ribose 5-phosphate isomerase
BI380_RS00815	COG1129	ABC transporter
BI380_RS00820	COG1879	ABC-type sugar transport system periplasmic component
BI380_RS00825	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS00830	COG1172	Belongs to the binding-protein-dependent transport system permease family
BI380_RS00835	COG1063	alcohol dehydrogenase
BI380_RS00845	COG1280	lysine exporter protein (LysE YggA)
BI380_RS00860	COG2367	Beta-lactamase
BI380_RS00865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BI380_RS00865	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BI380_RS00875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI380_RS00890	COG2814	Major facilitator Superfamily
BI380_RS00935	COG1942	4-Oxalocrotonate Tautomerase
BI380_RS00965	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BI380_RS00975	COG1643	Atp-dependent helicase
BI380_RS00995	COG3209	COG3209 Rhs family protein
BI380_RS01015	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS01035	COG1959	2 iron, 2 sulfur cluster binding
BI380_RS01045	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BI380_RS01070	COG1309	transcriptional regulator
BI380_RS01090	COG1116	anion transmembrane transporter activity
BI380_RS01095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI380_RS01105	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS01110	COG0840	transmembrane signaling receptor activity
BI380_RS01140	COG2199	diguanylate cyclase activity
BI380_RS01140	COG2200	EAL domain
BI380_RS01140	COG2202	Pas domain
BI380_RS01150	COG1794	racemase activity, acting on amino acids and derivatives
BI380_RS01155	COG3300	MHYT domain
BI380_RS01155	COG5001	Diguanylate cyclase
BI380_RS01170	COG0789	Transcriptional regulator
BI380_RS01190	COG4251	negative regulation of phosphorylation
BI380_RS01190	COG3706	GGDEF domain
BI380_RS01190	COG2203	Gaf domain
BI380_RS01190	COG5001	Diguanylate cyclase
BI380_RS01220	COG1129	ABC transporter
BI380_RS01235	COG3209	COG3209 Rhs family protein
BI380_RS01240	COG3209	COG3209 Rhs family protein
BI380_RS01270	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS01275	COG1024	Enoyl-CoA hydratase
BI380_RS01305	COG1309	transcriptional regulator
BI380_RS01320	COG1131	(ABC) transporter
BI380_RS01345	COG0583	DNA-binding transcription factor activity
BI380_RS01350	COG3618	amidohydrolase
BI380_RS01355	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS01365	COG2828	Protein conserved in bacteria
BI380_RS01375	COG2159	amidohydrolase
BI380_RS01415	COG0667	Aldo Keto reductase
BI380_RS01425	COG1414	Transcriptional regulator
BI380_RS01430	COG0477	Major facilitator Superfamily
BI380_RS01435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BI380_RS01450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BI380_RS01455	COG2814	Major facilitator Superfamily
BI380_RS01470	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS01475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI380_RS01530	COG1846	Transcriptional regulator
BI380_RS01535	COG0697	spore germination
BI380_RS01540	COG0778	Nitroreductase
BI380_RS01550	COG0864	Transcriptional regulator
BI380_RS01570	COG3119	arylsulfatase activity
BI380_RS01580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI380_RS01585	COG1522	sequence-specific DNA binding
BI380_RS01600	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BI380_RS01605	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BI380_RS01615	COG4208	sulfate ABC transporter
BI380_RS01625	COG1609	Transcriptional regulator
BI380_RS01650	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BI380_RS01655	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
BI380_RS01665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI380_RS01670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS01675	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS01695	COG2205	protein histidine kinase activity
BI380_RS01700	COG0745	RESPONSE REGULATOR receiver
BI380_RS01710	COG1629	transport
BI380_RS01710	COG4774	siderophore transport
BI380_RS01720	COG1120	ATPase activity
BI380_RS01725	COG4592	Periplasmic binding protein
BI380_RS01730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI380_RS01735	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI380_RS01790	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS01795	COG3415	Transposase
BI380_RS01795	COG2801	Transposase and inactivated derivatives
BI380_RS01810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI380_RS01815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI380_RS01820	COG2011	ABC-type metal ion transport system permease component
BI380_RS01830	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BI380_RS01845	COG0583	DNA-binding transcription factor activity
BI380_RS01855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI380_RS01860	COG1172	Belongs to the binding-protein-dependent transport system permease family
BI380_RS01865	COG1129	ABC transporter
BI380_RS01870	COG1879	ABC-type sugar transport system periplasmic component
BI380_RS01875	COG1349	DNA-binding transcription factor activity
BI380_RS01890	COG1396	sequence-specific DNA binding
BI380_RS01905	COG0529	Catalyzes the synthesis of activated sulfate
BI380_RS01920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI380_RS01925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI380_RS01985	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS01990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BI380_RS02020	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BI380_RS02025	COG0308	aminopeptidase N
BI380_RS02030	COG0840	transmembrane signaling receptor activity
BI380_RS02035	COG2199	diguanylate cyclase activity
BI380_RS02035	COG2202	Pas domain
BI380_RS02035	COG2200	EAL domain
BI380_RS02040	COG1595	DNA-templated transcription, initiation
BI380_RS02045	COG3712	iron ion homeostasis
BI380_RS02055	COG1595	DNA-templated transcription, initiation
BI380_RS02060	COG3712	iron ion homeostasis
BI380_RS02095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI380_RS02100	COG0577	efflux transmembrane transporter activity
BI380_RS02100	COG1136	(ABC) transporter
BI380_RS02125	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI380_RS02140	COG2022	thiamine diphosphate biosynthetic process
BI380_RS02155	COG0351	phosphomethylpyrimidine kinase
BI380_RS02170	COG4774	siderophore transport
BI380_RS02175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI380_RS02185	COG2917	probably involved in intracellular septation
BI380_RS02190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI380_RS02195	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BI380_RS02215	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS02230	COG0559	Belongs to the binding-protein-dependent transport system permease family
BI380_RS02240	COG0411	ABC transporter
BI380_RS02265	COG0183	Belongs to the thiolase family
BI380_RS02270	COG1960	acyl-CoA dehydrogenase activity
BI380_RS02300	COG1017	nitric oxide dioxygenase activity
BI380_RS02300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BI380_RS02305	COG0625	glutathione transferase activity
BI380_RS02315	COG4771	TonB-dependent receptor
BI380_RS02320	COG0745	RESPONSE REGULATOR receiver
BI380_RS02325	COG2205	protein histidine kinase activity
BI380_RS02340	COG0655	NAD(P)H dehydrogenase (quinone) activity
BI380_RS02370	COG3639	organic phosphonate transmembrane transporter activity
BI380_RS02375	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BI380_RS02380	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BI380_RS02390	COG4948	Mandelate Racemase Muconate Lactonizing
BI380_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS02405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI380_RS02410	COG0583	DNA-binding transcription factor activity
BI380_RS02415	COG1620	l-lactate permease
BI380_RS02420	COG2186	Transcriptional regulator
BI380_RS02425	COG1304	FMN binding
BI380_RS02430	COG0277	FAD linked oxidase domain protein
BI380_RS02435	COG1012	belongs to the aldehyde dehydrogenase family
BI380_RS02450	COG4772	TonB-dependent receptor
BI380_RS02465	COG0148	phosphopyruvate hydratase activity
BI380_RS02480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BI380_RS02495	COG2130	NADP-dependent
BI380_RS02510	COG2814	Major facilitator Superfamily
BI380_RS02515	COG2814	Major facilitator Superfamily
BI380_RS02545	COG2183	response to ionizing radiation
BI380_RS02575	COG2197	response regulator
BI380_RS02585	COG0628	permease
BI380_RS02595	COG0657	acetylesterase activity
BI380_RS02610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BI380_RS02615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BI380_RS02620	COG0470	DNA polymerase III
BI380_RS02630	COG0084	hydrolase, TatD family'
BI380_RS02635	COG0666	response to abiotic stimulus
BI380_RS02640	COG1132	(ABC) transporter
BI380_RS02645	COG0823	Involved in the tonB-independent uptake of proteins
BI380_RS02660	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BI380_RS02735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI380_RS02735	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI380_RS02745	COG2974	May be involved in recombination
BI380_RS02750	COG2916	Histone family protein nucleoid-structuring protein H-NS
BI380_RS02885	COG0740	serine-type endopeptidase activity
BI380_RS02965	COG3179	chitinase
BI380_RS03005	COG0582	viral genome integration into host DNA
BI380_RS03015	COG0582	viral genome integration into host DNA
BI380_RS03055	COG2916	Histone family protein nucleoid-structuring protein H-NS
BI380_RS03060	COG2916	Histone family protein nucleoid-structuring protein H-NS
BI380_RS03150	COG0457	Tetratricopeptide repeat
BI380_RS03150	COG0463	Glycosyl transferase, family 2
BI380_RS03350	COG0840	transmembrane signaling receptor activity
BI380_RS03355	COG2916	Histone family protein nucleoid-structuring protein H-NS
BI380_RS03375	COG2366	antibiotic biosynthetic process
BI380_RS03395	COG2199	diguanylate cyclase activity
BI380_RS03410	COG3276	selenocysteine insertion sequence binding
BI380_RS03425	COG2864	formate dehydrogenase
BI380_RS03430	COG0437	4 iron, 4 sulfur cluster binding
BI380_RS03435	COG0243	molybdopterin cofactor binding
BI380_RS03435	COG3383	formate dehydrogenase (NAD+) activity
BI380_RS03440	COG3383	formate dehydrogenase (NAD+) activity
BI380_RS03440	COG0243	molybdopterin cofactor binding
BI380_RS03445	COG0628	permease
BI380_RS03450	COG0567	Dehydrogenase, E1 component
BI380_RS03455	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI380_RS03460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI380_RS03465	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BI380_RS03480	COG1199	ATP-dependent helicase activity
BI380_RS03495	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BI380_RS03500	COG0542	response to heat
BI380_RS03505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI380_RS03510	COG2925	Exonuclease
BI380_RS03515	COG0700	Nucleoside recognition
BI380_RS03520	COG0346	lactoylglutathione lyase activity
BI380_RS03525	COG4106	trans-aconitate 2-methyltransferase activity
BI380_RS03565	COG2133	pyrroloquinoline quinone binding
BI380_RS03570	COG0217	transcriptional regulatory protein
BI380_RS03575	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BI380_RS03585	COG0433	COG0433 Predicted ATPase
BI380_RS03590	COG0217	transcriptional regulatory protein
BI380_RS03595	COG0151	Belongs to the GarS family
BI380_RS03600	COG0408	coproporphyrinogen oxidase activity
BI380_RS03605	COG0799	negative regulation of ribosome biogenesis
BI380_RS03610	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BI380_RS03615	COG0424	maF-like protein
BI380_RS03620	COG1530	ribonuclease E activity
BI380_RS03650	COG0436	Aminotransferase
BI380_RS03655	COG0583	DNA-binding transcription factor activity
BI380_RS03675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI380_RS03690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI380_RS03710	COG2916	Histone family protein nucleoid-structuring protein H-NS
BI380_RS03725	COG2974	May be involved in recombination
BI380_RS04050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BI380_RS04060	COG3712	iron ion homeostasis
BI380_RS04085	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI380_RS04090	COG0252	asparaginase activity
BI380_RS04095	COG0563	adenylate kinase activity
BI380_RS04100	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BI380_RS04105	COG2835	tetraacyldisaccharide 4'-kinase activity
BI380_RS04110	COG1663	tetraacyldisaccharide 4'-kinase activity
BI380_RS04115	COG0848	biopolymer transport protein
BI380_RS04120	COG0811	peptide transport
BI380_RS04125	COG1570	exodeoxyribonuclease VII activity
BI380_RS04130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BI380_RS04195	COG1196	nuclear chromosome segregation
BI380_RS04205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BI380_RS04210	COG1752	Esterase of the alpha-beta hydrolase superfamily
BI380_RS04230	COG0625	glutathione transferase activity
BI380_RS04245	COG3243	poly(R)-hydroxyalkanoic acid synthase
BI380_RS04250	COG0183	Belongs to the thiolase family
BI380_RS04255	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS04265	COG0765	amino acid transport
BI380_RS04270	COG4597	amino acid ABC transporter
BI380_RS04275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BI380_RS04285	COG0488	(ABC) transporter
BI380_RS04295	COG1960	acyl-CoA dehydrogenase activity
BI380_RS04300	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS04310	COG2890	protein-(glutamine-N5) methyltransferase activity
BI380_RS04315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI380_RS04325	COG2171	N-acyltransferase activity
BI380_RS04330	COG0436	Aminotransferase
BI380_RS04335	COG0840	transmembrane signaling receptor activity
BI380_RS04340	COG2878	Part of a membrane complex involved in electron transport
BI380_RS04350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI380_RS04370	COG3415	Transposase
BI380_RS04370	COG2801	Transposase and inactivated derivatives
BI380_RS04405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI380_RS04410	COG2610	gluconate transmembrane transporter activity
BI380_RS04420	COG0724	RNA recognition motif
BI380_RS04435	COG0523	cobalamin synthesis protein
BI380_RS04440	COG1469	GTP cyclohydrolase I activity
BI380_RS04445	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BI380_RS04455	COG0735	belongs to the Fur family
BI380_RS04465	COG1846	Transcriptional regulator
BI380_RS04475	COG4774	siderophore transport
BI380_RS04515	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BI380_RS04525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS04545	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS04550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS04565	COG0583	DNA-binding transcription factor activity
BI380_RS04570	COG4191	Histidine kinase
BI380_RS04570	COG0784	Response regulator, receiver
BI380_RS04595	COG0133	tryptophan synthase activity
BI380_RS04665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI380_RS04675	COG0583	DNA-binding transcription factor activity
BI380_RS04680	COG1752	Esterase of the alpha-beta hydrolase superfamily
BI380_RS04685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BI380_RS04690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BI380_RS04700	COG3135	benzoate transporter
BI380_RS04725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BI380_RS04740	COG0393	Putative heavy-metal-binding
BI380_RS04750	COG4206	TonB-dependent receptor
BI380_RS04760	COG1476	TRANSCRIPTIONal
BI380_RS04770	COG2207	Transcriptional regulator
BI380_RS04775	COG2814	Major facilitator Superfamily
BI380_RS04790	COG4771	TonB-dependent receptor
BI380_RS04795	COG1113	amino acid transport
BI380_RS04810	COG2814	Major facilitator Superfamily
BI380_RS04815	COG1566	PFAM secretion protein HlyD family protein
BI380_RS04840	COG3209	COG3209 Rhs family protein
BI380_RS04855	COG3209	COG3209 Rhs family protein
BI380_RS04890	COG0840	transmembrane signaling receptor activity
BI380_RS04895	COG1022	Amp-dependent synthetase and ligase
BI380_RS04900	COG1802	Transcriptional regulator
BI380_RS04905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BI380_RS04905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BI380_RS04910	COG1703	isobutyryl-CoA mutase activity
BI380_RS04915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BI380_RS04920	COG4770	biotin carboxylase activity
BI380_RS04925	COG1609	Transcriptional regulator
BI380_RS04930	COG3265	gluconokinase activity
BI380_RS04935	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BI380_RS04940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BI380_RS04945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI380_RS04955	COG0800	Aldolase
BI380_RS04960	COG0583	DNA-binding transcription factor activity
BI380_RS05000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BI380_RS05015	COG0840	transmembrane signaling receptor activity
BI380_RS05035	COG1120	ATPase activity
BI380_RS05040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI380_RS05085	COG0835	chemotaxis
BI380_RS05090	COG0840	transmembrane signaling receptor activity
BI380_RS05105	COG0583	DNA-binding transcription factor activity
BI380_RS05130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI380_RS05135	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BI380_RS05140	COG2080	2 iron, 2 sulfur cluster binding
BI380_RS05145	COG2255	four-way junction helicase activity
BI380_RS05170	COG5001	Diguanylate cyclase
BI380_RS05175	COG1597	lipid kinase activity
BI380_RS05190	COG2205	protein histidine kinase activity
BI380_RS05200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI380_RS05220	COG0840	transmembrane signaling receptor activity
BI380_RS05230	COG1802	Transcriptional regulator
BI380_RS05420	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS05435	COG1309	transcriptional regulator
BI380_RS05440	COG1902	pentaerythritol trinitrate reductase activity
BI380_RS05445	COG0702	epimerase
BI380_RS05450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BI380_RS05475	COG1764	response to oxidative stress
BI380_RS05515	COG2826	transposase and inactivated derivatives, IS30 family
BI380_RS05540	COG1609	Transcriptional regulator
BI380_RS05545	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS05565	COG2985	domain, Protein
BI380_RS05580	COG0583	DNA-binding transcription factor activity
BI380_RS05590	COG3781	membrane
BI380_RS05615	COG1309	transcriptional regulator
BI380_RS05625	COG2010	Cytochrome c
BI380_RS05625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI380_RS05630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI380_RS05630	COG2010	Cytochrome c
BI380_RS05635	COG2080	2 iron, 2 sulfur cluster binding
BI380_RS05645	COG2916	Histone family protein nucleoid-structuring protein H-NS
BI380_RS05655	COG2197	response regulator
BI380_RS05665	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BI380_RS05670	COG2197	response regulator
BI380_RS05675	COG0346	lactoylglutathione lyase activity
BI380_RS05690	COG2032	superoxide dismutase activity
BI380_RS05730	COG0259	pyridoxamine-phosphate oxidase activity
BI380_RS05765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI380_RS05770	COG1309	transcriptional regulator
BI380_RS05785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI380_RS05795	COG1538	Outer membrane efflux protein
BI380_RS05815	COG1487	ribonuclease activity
BI380_RS05830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BI380_RS05840	COG0791	NLP P60 protein
BI380_RS05855	COG0625	glutathione transferase activity
BI380_RS05875	COG1280	lysine exporter protein (LysE YggA)
BI380_RS05885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI380_RS05890	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI380_RS05905	COG4566	intracellular signal transduction
BI380_RS05910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BI380_RS05930	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BI380_RS05935	COG0167	dihydroorotate dehydrogenase activity
BI380_RS05955	COG0579	oxidoreductase
BI380_RS05995	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BI380_RS06005	COG0822	iron-sulfur transferase activity
BI380_RS06010	COG1104	cysteine desulfurase activity
BI380_RS06015	COG1959	2 iron, 2 sulfur cluster binding
BI380_RS06020	COG0556	nucleotide-excision repair
BI380_RS06030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS06035	COG5002	protein histidine kinase activity
BI380_RS06035	COG5001	Diguanylate cyclase
BI380_RS06045	COG2207	Transcriptional regulator
BI380_RS06055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI380_RS06065	COG1739	Uncharacterized protein family UPF0029
BI380_RS06070	COG1473	amidohydrolase
BI380_RS06105	COG4178	(ABC) transporter
BI380_RS06120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BI380_RS06150	COG5507	3-demethylubiquinone-9 3-methyltransferase
BI380_RS06155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI380_RS06160	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BI380_RS06165	COG4181	ATPase activity
BI380_RS06200	COG0659	secondary active sulfate transmembrane transporter activity
BI380_RS06205	COG3706	GGDEF domain
BI380_RS06215	COG1054	Belongs to the UPF0176 family
BI380_RS06220	COG1414	Transcriptional regulator
BI380_RS06230	COG0765	amino acid transport
BI380_RS06235	COG1126	abc transporter atp-binding protein
BI380_RS06240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI380_RS06255	COG1741	Belongs to the pirin family
BI380_RS06260	COG0583	DNA-binding transcription factor activity
BI380_RS06265	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BI380_RS06270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI380_RS06275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BI380_RS06295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BI380_RS06310	COG0477	Major facilitator Superfamily
BI380_RS06320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BI380_RS06325	COG1845	cytochrome c oxidase, subunit III
BI380_RS06330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BI380_RS06345	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BI380_RS06350	COG0109	protoheme IX farnesyltransferase activity
BI380_RS06355	COG1612	heme a metabolic process
BI380_RS06380	COG2226	methyltransferase
BI380_RS06400	COG2826	transposase and inactivated derivatives, IS30 family
BI380_RS06410	COG0582	viral genome integration into host DNA
BI380_RS06470	COG2003	Belongs to the UPF0758 family
BI380_RS06535	COG3621	Patatin-like phospholipase
BI380_RS06705	COG1192	Involved in chromosome partitioning
BI380_RS06720	COG0583	DNA-binding transcription factor activity
BI380_RS06740	COG0071	Belongs to the small heat shock protein (HSP20) family
BI380_RS06745	COG0542	response to heat
BI380_RS06755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BI380_RS06800	COG0501	Belongs to the peptidase M48B family
BI380_RS06805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI380_RS06810	COG0583	DNA-binding transcription factor activity
BI380_RS06840	COG3552	Protein containing von Willebrand factor type A (VWA) domain
BI380_RS06850	COG0714	Associated with various cellular activities
BI380_RS06870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BI380_RS06880	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BI380_RS06890	COG1253	flavin adenine dinucleotide binding
BI380_RS06915	COG0735	belongs to the Fur family
BI380_RS06925	COG3258	Cytochrome c
BI380_RS06935	COG0642	Histidine kinase
BI380_RS06945	COG1309	transcriptional regulator
BI380_RS06950	COG2814	Major facilitator Superfamily
BI380_RS06990	COG1538	Outer membrane efflux protein
BI380_RS07010	COG0564	pseudouridine synthase activity
BI380_RS07025	COG1802	Transcriptional regulator
BI380_RS07035	COG3246	L-lysine catabolic process to acetate
BI380_RS07055	COG2982	Protein involved in outer membrane biogenesis
BI380_RS07070	COG0587	DNA-directed DNA polymerase activity
BI380_RS07085	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BI380_RS07105	COG0753	catalase activity
BI380_RS07115	COG0446	pyridine nucleotide-disulphide oxidoreductase
BI380_RS07115	COG1902	pentaerythritol trinitrate reductase activity
BI380_RS07125	COG3386	PFAM SMP-30 Gluconolaconase
BI380_RS07145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI380_RS07150	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI380_RS07155	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS07180	COG0596	Alpha beta hydrolase
BI380_RS07185	COG0583	DNA-binding transcription factor activity
BI380_RS07195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS07205	COG1609	Transcriptional regulator
BI380_RS07230	COG4191	Histidine kinase
BI380_RS07235	COG1301	dicarboxylic acid transport
BI380_RS07240	COG0840	transmembrane signaling receptor activity
BI380_RS07250	COG3040	lipid binding
BI380_RS07315	COG3842	ATPase activity
BI380_RS07320	COG0395	ABC-type sugar transport system, permease component
BI380_RS07325	COG1175	transmembrane transport
BI380_RS07335	COG1012	belongs to the aldehyde dehydrogenase family
BI380_RS07340	COG1024	Enoyl-CoA hydratase
BI380_RS07350	COG0673	inositol 2-dehydrogenase activity
BI380_RS07355	COG1609	Transcriptional regulator
BI380_RS07365	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BI380_RS07385	COG4120	Belongs to the binding-protein-dependent transport system permease family
BI380_RS07390	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BI380_RS07395	COG0662	Cupin 2, conserved barrel domain protein
BI380_RS07410	COG0583	DNA-binding transcription factor activity
BI380_RS07415	COG0833	amino acid
BI380_RS07435	COG2205	protein histidine kinase activity
BI380_RS07455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BI380_RS07465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI380_RS07465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI380_RS07475	COG0564	pseudouridine synthase activity
BI380_RS07515	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS07540	COG0753	catalase activity
BI380_RS07550	COG2204	response regulator
BI380_RS07570	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BI380_RS07600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BI380_RS07630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI380_RS07635	COG1414	Transcriptional regulator
BI380_RS07730	COG0604	alcohol dehydrogenase
BI380_RS07735	COG1309	transcriptional regulator
BI380_RS07750	COG0765	amino acid transport
BI380_RS07755	COG0765	amino acid transport
BI380_RS07765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS07770	COG2814	Major facilitator Superfamily
BI380_RS07800	COG0583	DNA-binding transcription factor activity
BI380_RS07810	COG1280	lysine exporter protein (LysE YggA)
BI380_RS07815	COG0583	DNA-binding transcription factor activity
BI380_RS07840	COG3321	synthase
BI380_RS07840	COG0604	alcohol dehydrogenase
BI380_RS07840	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS07845	COG0583	DNA-binding transcription factor activity
BI380_RS07850	COG4628	conserved protein (DUF2132)
BI380_RS07855	COG0840	transmembrane signaling receptor activity
BI380_RS07895	COG0598	Magnesium transport protein CorA
BI380_RS07935	COG0840	transmembrane signaling receptor activity
BI380_RS07945	COG2197	response regulator
BI380_RS07950	COG2205	protein histidine kinase activity
BI380_RS07950	COG0784	Response regulator, receiver
BI380_RS07955	COG2203	Gaf domain
BI380_RS07955	COG2199	diguanylate cyclase activity
BI380_RS07955	COG2200	EAL domain
BI380_RS07960	COG0784	Response regulator, receiver
BI380_RS07960	COG2205	protein histidine kinase activity
BI380_RS07985	COG0069	glutamate synthase activity
BI380_RS07990	COG5002	protein histidine kinase activity
BI380_RS07995	COG0745	RESPONSE REGULATOR receiver
BI380_RS08000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI380_RS08010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI380_RS08030	COG4774	siderophore transport
BI380_RS08040	COG1802	Transcriptional regulator
BI380_RS08045	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BI380_RS08050	COG0247	lactate metabolic process
BI380_RS08055	COG1802	Transcriptional regulator
BI380_RS08100	COG1201	RNA secondary structure unwinding
BI380_RS08105	COG1793	dna ligase
BI380_RS08110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BI380_RS08110	COG1793	dna ligase
BI380_RS08145	COG2814	Major facilitator Superfamily
BI380_RS08155	COG0583	DNA-binding transcription factor activity
BI380_RS08175	COG2072	flavoprotein involved in K transport
BI380_RS08205	COG2368	4-hydroxyphenylacetate
BI380_RS08215	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BI380_RS08240	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS08250	COG0612	Peptidase, M16
BI380_RS08270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI380_RS08270	COG0519	Catalyzes the synthesis of GMP from XMP
BI380_RS08285	COG0583	DNA-binding transcription factor activity
BI380_RS08290	COG0129	dihydroxy-acid dehydratase activity
BI380_RS08310	COG2867	negative regulation of translational initiation
BI380_RS08315	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BI380_RS08345	COG1024	Enoyl-CoA hydratase
BI380_RS08360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS08365	COG0583	DNA-binding transcription factor activity
BI380_RS08375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BI380_RS08380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BI380_RS08385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BI380_RS08390	COG0195	Participates in both transcription termination and antitermination
BI380_RS08395	COG0779	Required for maturation of 30S ribosomal subunits
BI380_RS08405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI380_RS08405	COG2010	Cytochrome c
BI380_RS08425	COG3040	lipid binding
BI380_RS08430	COG4172	Belongs to the ABC transporter superfamily
BI380_RS08435	COG4239	(ABC) transporter, permease
BI380_RS08440	COG4174	ABC transporter (Permease)
BI380_RS08445	COG4166	transmembrane transport
BI380_RS08465	COG1414	Transcriptional regulator
BI380_RS08470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI380_RS08475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS08515	COG0784	Response regulator, receiver
BI380_RS08515	COG4191	Histidine kinase
BI380_RS08535	COG2814	Major facilitator Superfamily
BI380_RS08560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BI380_RS08570	COG1215	transferase activity, transferring glycosyl groups
BI380_RS08590	COG1696	Membrane protein involved in D-alanine export
BI380_RS08595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI380_RS08610	COG1960	acyl-CoA dehydrogenase activity
BI380_RS08620	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BI380_RS08630	COG3962	Belongs to the TPP enzyme family
BI380_RS08640	COG1129	ABC transporter
BI380_RS08645	COG4211	Belongs to the binding-protein-dependent transport system permease family
BI380_RS08650	COG1082	Xylose isomerase domain protein TIM barrel
BI380_RS08660	COG0673	inositol 2-dehydrogenase activity
BI380_RS08670	COG0673	inositol 2-dehydrogenase activity
BI380_RS08680	COG1301	dicarboxylic acid transport
BI380_RS08685	COG0784	Response regulator, receiver
BI380_RS08685	COG2198	Histidine kinase
BI380_RS08685	COG2205	protein histidine kinase activity
BI380_RS08715	COG0789	Transcriptional regulator
BI380_RS08745	COG2132	Multicopper oxidase
BI380_RS08750	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BI380_RS08765	COG3191	aminopeptidase activity
BI380_RS08770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI380_RS08780	COG0488	(ABC) transporter
BI380_RS08785	COG0513	Belongs to the DEAD box helicase family
BI380_RS08800	COG0582	viral genome integration into host DNA
BI380_RS08840	COG1252	NADH dehydrogenase
BI380_RS08855	COG2072	flavoprotein involved in K transport
BI380_RS08865	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BI380_RS08870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BI380_RS08880	COG0657	acetylesterase activity
BI380_RS08885	COG2072	flavoprotein involved in K transport
BI380_RS08970	COG1858	cytochrome C peroxidase
BI380_RS08985	COG0583	DNA-binding transcription factor activity
BI380_RS08995	COG1335	isochorismatase
BI380_RS09000	COG1335	isochorismatase
BI380_RS09045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI380_RS09055	COG0776	regulation of translation
BI380_RS09065	COG0322	excinuclease ABC activity
BI380_RS09075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI380_RS09080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS09085	COG0583	DNA-binding transcription factor activity
BI380_RS09095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI380_RS09105	COG0534	Mate efflux family protein
BI380_RS09115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI380_RS09225	COG4695	Portal protein
BI380_RS09230	COG4626	Terminase
BI380_RS09230	COG1802	Transcriptional regulator
BI380_RS09290	COG1475	DNA binding
BI380_RS09310	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
BI380_RS09330	COG1953	Uracil, thiamine, allantoin
BI380_RS09340	COG0493	'glutamate synthase
BI380_RS09340	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BI380_RS09350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BI380_RS09360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI380_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS09390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BI380_RS09390	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BI380_RS09395	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BI380_RS09395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BI380_RS09400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BI380_RS09410	COG0560	Phosphoserine phosphatase
BI380_RS09485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS09490	COG3530	Putative quorum-sensing-regulated virulence factor
BI380_RS09505	COG1522	sequence-specific DNA binding
BI380_RS09520	COG0583	DNA-binding transcription factor activity
BI380_RS09535	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS09540	COG1473	amidohydrolase
BI380_RS09545	COG2900	Belongs to the SlyX family
BI380_RS09550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS09555	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS09560	COG0154	amidase activity
BI380_RS09570	COG4804	nuclease activity
BI380_RS09575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BI380_RS09615	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BI380_RS09620	COG2186	Transcriptional regulator
BI380_RS09625	COG0235	Class ii aldolase
BI380_RS09630	COG2271	Major facilitator Superfamily
BI380_RS09635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI380_RS09640	COG2084	Dehydrogenase
BI380_RS09645	COG3395	kinase activity
BI380_RS09650	COG3622	Belongs to the hyi family
BI380_RS09665	COG1492	cobalamin metabolic process
BI380_RS09675	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI380_RS09680	COG0778	Nitroreductase
BI380_RS09685	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BI380_RS09715	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BI380_RS09720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI380_RS09725	COG4607	ABC-type enterochelin transport system periplasmic component
BI380_RS09735	COG1797	cobyrinic acid a,c-diamide synthase activity
BI380_RS09750	COG0730	response to heat
BI380_RS09755	COG5001	Diguanylate cyclase
BI380_RS09755	COG3300	MHYT domain
BI380_RS09770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BI380_RS09775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI380_RS09790	COG0348	domain, Protein
BI380_RS09810	COG3278	Belongs to the heme-copper respiratory oxidase family
BI380_RS09820	COG2217	Heavy metal translocating P-type atpase
BI380_RS09825	COG0589	response to stress
BI380_RS09830	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS09835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS09845	COG1024	Enoyl-CoA hydratase
BI380_RS09870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BI380_RS09875	COG1846	Transcriptional regulator
BI380_RS09880	COG1960	acyl-CoA dehydrogenase activity
BI380_RS09895	COG1024	Enoyl-CoA hydratase
BI380_RS09900	COG2193	ferroxidase activity
BI380_RS09905	COG0129	dihydroxy-acid dehydratase activity
BI380_RS09915	COG4654	Cytochrome c, class I
BI380_RS09925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BI380_RS09935	COG4175	Glycine betaine
BI380_RS09940	COG4176	ABC-type proline glycine betaine transport system permease component
BI380_RS09945	COG2113	Glycine betaine
BI380_RS09950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI380_RS09950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI380_RS09955	COG1105	Belongs to the carbohydrate kinase PfkB family
BI380_RS09960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI380_RS09960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI380_RS09965	COG1609	Transcriptional regulator
BI380_RS09980	COG2814	Major facilitator Superfamily
BI380_RS09990	COG0114	fumarate hydratase activity
BI380_RS10010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BI380_RS10015	COG1451	nucleotide metabolic process
BI380_RS10180	COG4626	Terminase
BI380_RS10180	COG1802	Transcriptional regulator
BI380_RS10265	COG0305	Participates in initiation and elongation during chromosome replication
BI380_RS10385	COG2916	Histone family protein nucleoid-structuring protein H-NS
BI380_RS10505	COG0629	single-stranded DNA binding
BI380_RS10510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI380_RS10525	COG0789	Transcriptional regulator
BI380_RS10535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BI380_RS10575	COG0789	Transcriptional regulator
BI380_RS10670	COG0431	NADPH-dependent FMN reductase
BI380_RS10675	COG1393	Belongs to the ArsC family
BI380_RS10680	COG0798	PFAM Bile acid sodium symporter
BI380_RS10780	COG2003	Belongs to the UPF0758 family
BI380_RS10835	COG5002	protein histidine kinase activity
BI380_RS10840	COG0745	RESPONSE REGULATOR receiver
BI380_RS10865	COG2217	Heavy metal translocating P-type atpase
BI380_RS10885	COG0583	DNA-binding transcription factor activity
BI380_RS10900	COG3039	Transposase
BI380_RS10915	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI380_RS10925	COG0582	viral genome integration into host DNA
BI380_RS10935	COG0501	Belongs to the peptidase M48B family
BI380_RS11200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BI380_RS11205	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BI380_RS11210	COG0740	serine-type endopeptidase activity
BI380_RS11370	COG3550	peptidyl-serine autophosphorylation
BI380_RS11380	COG0582	viral genome integration into host DNA
BI380_RS11390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI380_RS11395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI380_RS11425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BI380_RS11440	COG0275	rRNA processing
BI380_RS11455	COG1011	Hydrolase
BI380_RS11460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BI380_RS11465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI380_RS11520	COG0583	DNA-binding transcription factor activity
BI380_RS11535	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BI380_RS11585	COG4774	siderophore transport
BI380_RS11590	COG4607	ABC-type enterochelin transport system periplasmic component
BI380_RS11595	COG4605	iron ion homeostasis
BI380_RS11600	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI380_RS11605	COG1132	(ABC) transporter
BI380_RS11610	COG1132	(ABC) transporter
BI380_RS11610	COG2375	cellular response to nickel ion
BI380_RS11615	COG3712	iron ion homeostasis
BI380_RS11620	COG1595	DNA-templated transcription, initiation
BI380_RS11650	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS11660	COG0642	Histidine kinase
BI380_RS11665	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BI380_RS11675	COG0402	S-adenosylhomocysteine deaminase activity
BI380_RS11720	COG0037	tRNA processing
BI380_RS11735	COG0215	cysteine-tRNA ligase activity
BI380_RS11755	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI380_RS11785	COG1522	sequence-specific DNA binding
BI380_RS11800	COG3384	dioxygenase
BI380_RS11815	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BI380_RS11825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI380_RS11840	COG3064	Membrane
BI380_RS11860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI380_RS11880	COG0564	pseudouridine synthase activity
BI380_RS11915	COG2918	glutathione biosynthetic process
BI380_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS11940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BI380_RS11945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI380_RS11950	COG0436	Aminotransferase
BI380_RS11955	COG0824	Thioesterase
BI380_RS11975	COG1690	Belongs to the RtcB family
BI380_RS11980	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BI380_RS11995	COG0826	peptidase U32
BI380_RS12010	COG4772	TonB-dependent receptor
BI380_RS12020	COG0129	dihydroxy-acid dehydratase activity
BI380_RS12035	COG0348	domain, Protein
BI380_RS12055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS12060	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS12065	COG1960	acyl-CoA dehydrogenase activity
BI380_RS12070	COG0583	DNA-binding transcription factor activity
BI380_RS12075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BI380_RS12115	COG4106	trans-aconitate 2-methyltransferase activity
BI380_RS12120	COG0039	L-malate dehydrogenase activity
BI380_RS12125	COG2188	Transcriptional regulator
BI380_RS12130	COG2009	succinate dehydrogenase
BI380_RS12135	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BI380_RS12140	COG1053	succinate dehydrogenase
BI380_RS12145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BI380_RS12150	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BI380_RS12155	COG0372	Belongs to the citrate synthase family
BI380_RS12170	COG0513	Belongs to the DEAD box helicase family
BI380_RS12185	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BI380_RS12190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI380_RS12205	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BI380_RS12210	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BI380_RS12215	COG0583	DNA-binding transcription factor activity
BI380_RS12225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI380_RS12245	COG1294	oxidase, subunit
BI380_RS12255	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BI380_RS12260	COG4988	ABC transporter
BI380_RS12270	COG1960	acyl-CoA dehydrogenase activity
BI380_RS12290	COG1511	domain protein
BI380_RS12290	COG3264	Mechanosensitive ion channel
BI380_RS12305	COG0714	Associated with various cellular activities
BI380_RS12320	COG2951	lytic endotransglycosylase activity
BI380_RS12325	COG0683	leucine binding
BI380_RS12335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BI380_RS12345	COG3707	response regulator
BI380_RS12350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI380_RS12355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI380_RS12360	COG1116	anion transmembrane transporter activity
BI380_RS12375	COG0840	transmembrane signaling receptor activity
BI380_RS12380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI380_RS12385	COG0243	molybdopterin cofactor binding
BI380_RS12400	COG2205	protein histidine kinase activity
BI380_RS12400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BI380_RS12405	COG1607	acyl-coa hydrolase
BI380_RS12410	COG2081	HI0933 family
BI380_RS12415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BI380_RS12425	COG0583	DNA-binding transcription factor activity
BI380_RS12430	COG0473	3-isopropylmalate dehydrogenase activity
BI380_RS12440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI380_RS12470	COG2721	sulfolactate sulfo-lyase activity
BI380_RS12475	COG1012	belongs to the aldehyde dehydrogenase family
BI380_RS12525	COG1309	transcriptional regulator
BI380_RS12545	COG0004	ammonium transporteR
BI380_RS12555	COG2719	SpoVR family
BI380_RS12560	COG2718	Belongs to the UPF0229 family
BI380_RS12565	COG2766	serine protein kinase
BI380_RS12570	COG1511	domain protein
BI380_RS12570	COG3264	Mechanosensitive ion channel
BI380_RS12575	COG0840	transmembrane signaling receptor activity
BI380_RS12580	COG0312	modulator of DNA gyrase
BI380_RS12585	COG3028	Belongs to the UPF0307 family
BI380_RS12590	COG0521	Mo-molybdopterin cofactor biosynthetic process
BI380_RS12600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI380_RS12605	COG0577	efflux transmembrane transporter activity
BI380_RS12605	COG1136	(ABC) transporter
BI380_RS12610	COG1538	Outer membrane efflux protein
BI380_RS12615	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BI380_RS12635	COG4948	Mandelate Racemase Muconate Lactonizing
BI380_RS12640	COG0179	Fumarylacetoacetate (FAA) hydrolase
BI380_RS12645	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS12655	COG1129	ABC transporter
BI380_RS12665	COG1414	Transcriptional regulator
BI380_RS12670	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BI380_RS12675	COG1518	maintenance of DNA repeat elements
BI380_RS12705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BI380_RS12715	COG1045	serine acetyltransferase
BI380_RS12725	COG0483	inositol monophosphate 1-phosphatase activity
BI380_RS12730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BI380_RS12735	COG0640	Transcriptional regulator
BI380_RS12745	COG1396	sequence-specific DNA binding
BI380_RS12795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI380_RS12810	COG3214	Protein conserved in bacteria
BI380_RS12820	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS12825	COG0028	Belongs to the TPP enzyme family
BI380_RS12835	COG1802	Transcriptional regulator
BI380_RS12850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BI380_RS12870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BI380_RS12875	COG1968	undecaprenyl-diphosphatase activity
BI380_RS12905	COG2972	Histidine kinase
BI380_RS12910	COG3279	Response regulator of the LytR AlgR family
BI380_RS12930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI380_RS12935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI380_RS12955	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BI380_RS13005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BI380_RS13010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BI380_RS13015	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BI380_RS13020	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BI380_RS13025	COG0142	geranyltranstransferase activity
BI380_RS13030	COG1722	exodeoxyribonuclease VII activity
BI380_RS13060	COG2200	EAL domain
BI380_RS13060	COG2199	diguanylate cyclase activity
BI380_RS13060	COG2203	Gaf domain
BI380_RS13065	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BI380_RS13070	COG0181	hydroxymethylbilane synthase activity
BI380_RS13125	COG3813	Protein conserved in bacteria
BI380_RS13140	COG0525	valine-tRNA ligase activity
BI380_RS13145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BI380_RS13150	COG0425	Belongs to the sulfur carrier protein TusA family
BI380_RS13185	COG1346	cytolysis
BI380_RS13190	COG0583	DNA-binding transcription factor activity
BI380_RS13195	COG1960	acyl-CoA dehydrogenase activity
BI380_RS13200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS13210	COG0583	DNA-binding transcription factor activity
BI380_RS13215	COG0590	tRNA wobble adenosine to inosine editing
BI380_RS13220	COG2807	transmembrane transport
BI380_RS13235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI380_RS13285	COG0617	tRNA 3'-terminal CCA addition
BI380_RS13295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BI380_RS13300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BI380_RS13315	COG0728	peptidoglycan biosynthetic process
BI380_RS13320	COG0268	Binds directly to 16S ribosomal RNA
BI380_RS13330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BI380_RS13335	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BI380_RS13345	COG0727	PFAM Uncharacterised protein family (UPF0153)
BI380_RS13365	COG0727	PFAM Uncharacterised protein family (UPF0153)
BI380_RS13370	COG1522	sequence-specific DNA binding
BI380_RS13375	COG1113	amino acid transport
BI380_RS13380	COG1448	Aminotransferase
BI380_RS13385	COG3483	tryptophan 2,3-dioxygenase activity
BI380_RS13390	COG0251	oxidation-reduction process
BI380_RS13400	COG2207	Transcriptional regulator
BI380_RS13405	COG1113	amino acid transport
BI380_RS13410	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BI380_RS13420	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BI380_RS13425	COG2169	Transcriptional regulator
BI380_RS13425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BI380_RS13430	COG3483	tryptophan 2,3-dioxygenase activity
BI380_RS13440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI380_RS13445	COG2916	Histone family protein nucleoid-structuring protein H-NS
BI380_RS13450	COG1253	flavin adenine dinucleotide binding
BI380_RS13455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BI380_RS13465	COG2948	multi-organism process
BI380_RS13470	COG3504	Conjugal transfer protein
BI380_RS13495	COG3451	type IV secretory pathway VirB4
BI380_RS13505	COG3838	Conjugal transfer protein Trbc
BI380_RS13530	COG0583	DNA-binding transcription factor activity
BI380_RS13545	COG1960	acyl-CoA dehydrogenase activity
BI380_RS13560	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS13570	COG1960	acyl-CoA dehydrogenase activity
BI380_RS13575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS13580	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS13585	COG0183	Belongs to the thiolase family
BI380_RS13600	COG0625	glutathione transferase activity
BI380_RS13660	COG1192	Involved in chromosome partitioning
BI380_RS13685	COG1396	sequence-specific DNA binding
BI380_RS13690	COG5489	Protein of unknown function (DUF736)
BI380_RS13695	COG2207	Transcriptional regulator
BI380_RS13700	COG0702	epimerase
BI380_RS13735	COG2003	Belongs to the UPF0758 family
BI380_RS13740	COG4804	nuclease activity
BI380_RS13750	COG0513	Belongs to the DEAD box helicase family
BI380_RS13755	COG2321	neutral zinc metallopeptidase
BI380_RS13765	COG2423	ornithine cyclodeaminase activity
BI380_RS13780	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BI380_RS13785	COG0717	Belongs to the dCTP deaminase family
BI380_RS13790	COG0402	S-adenosylhomocysteine deaminase activity
BI380_RS13800	COG0537	adenosine 5'-monophosphoramidase activity
BI380_RS13805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BI380_RS13830	COG4603	Belongs to the binding-protein-dependent transport system permease family
BI380_RS13835	COG3845	ABC transporter
BI380_RS13855	COG3447	MASE1 domain protein
BI380_RS13855	COG5001	Diguanylate cyclase
BI380_RS13855	COG5002	protein histidine kinase activity
BI380_RS13865	COG5001	Diguanylate cyclase
BI380_RS13865	COG3300	MHYT domain
BI380_RS13910	COG0405	Gamma-glutamyltransferase
BI380_RS13915	COG2084	Dehydrogenase
BI380_RS13920	COG3622	Belongs to the hyi family
BI380_RS13925	COG3960	tartronate-semialdehyde synthase activity
BI380_RS13930	COG0583	DNA-binding transcription factor activity
BI380_RS13950	COG0583	DNA-binding transcription factor activity
BI380_RS13955	COG2186	Transcriptional regulator
BI380_RS13975	COG2233	PERMEase
BI380_RS13980	COG0280	phosphate acetyltransferase
BI380_RS13980	COG0281	malic enzyme
BI380_RS14170	COG4626	Terminase
BI380_RS14170	COG1802	Transcriptional regulator
BI380_RS14360	COG2916	Histone family protein nucleoid-structuring protein H-NS
BI380_RS14410	COG0582	viral genome integration into host DNA
BI380_RS14440	COG0583	DNA-binding transcription factor activity
BI380_RS14465	COG1309	transcriptional regulator
BI380_RS14480	COG0154	amidase activity
BI380_RS14500	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS14510	COG0523	cobalamin synthesis protein
BI380_RS14545	COG2885	chlorophyll binding
BI380_RS14555	COG2274	protein secretion by the type I secretion system
BI380_RS14560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI380_RS14590	COG4964	Belongs to the GSP D family
BI380_RS14640	COG3604	Transcriptional regulator
BI380_RS14645	COG0438	transferase activity, transferring glycosyl groups
BI380_RS14660	COG4191	Histidine kinase
BI380_RS14690	COG0740	serine-type endopeptidase activity
BI380_RS14735	COG0513	Belongs to the DEAD box helicase family
BI380_RS14745	COG0300	oxidoreductase activity
BI380_RS14760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BI380_RS14770	COG1609	Transcriptional regulator
BI380_RS14775	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS14795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BI380_RS14800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BI380_RS14815	COG1561	YicC-like family, N-terminal region
BI380_RS14820	COG0194	GDP metabolic process
BI380_RS14825	COG1758	RNA polymerase activity
BI380_RS14830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI380_RS14840	COG2951	lytic endotransglycosylase activity
BI380_RS14860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS14865	COG1113	amino acid transport
BI380_RS14895	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BI380_RS14910	COG2175	clavaminate synthase activity
BI380_RS14915	COG3246	L-lysine catabolic process to acetate
BI380_RS14935	COG3246	L-lysine catabolic process to acetate
BI380_RS14940	COG2175	clavaminate synthase activity
BI380_RS14945	COG2207	Transcriptional regulator
BI380_RS14950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI380_RS14955	COG2146	nitrite reductase [NAD(P)H] activity
BI380_RS14985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI380_RS15000	COG3706	GGDEF domain
BI380_RS15005	COG1999	signal sequence binding
BI380_RS15025	COG2267	carboxylic ester hydrolase activity
BI380_RS15040	COG1414	Transcriptional regulator
BI380_RS15055	COG2855	membrane
BI380_RS15085	COG1228	amidohydrolase
BI380_RS15090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI380_RS15110	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BI380_RS15140	COG2916	Histone family protein nucleoid-structuring protein H-NS
BI380_RS15150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BI380_RS15155	COG0617	tRNA 3'-terminal CCA addition
BI380_RS15155	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BI380_RS15155	COG0517	IMP dehydrogenase activity
BI380_RS15160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BI380_RS15165	COG1047	Peptidyl-prolyl cis-trans
BI380_RS15170	COG2003	Belongs to the UPF0758 family
BI380_RS15195	COG0737	Belongs to the 5'-nucleotidase family
BI380_RS15205	COG0583	DNA-binding transcription factor activity
BI380_RS15215	COG0583	DNA-binding transcription factor activity
BI380_RS15220	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS15225	COG0697	spore germination
BI380_RS15230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS15240	COG2814	Major facilitator Superfamily
BI380_RS15250	COG4774	siderophore transport
BI380_RS15270	COG0745	RESPONSE REGULATOR receiver
BI380_RS15275	COG0745	RESPONSE REGULATOR receiver
BI380_RS15280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BI380_RS15280	COG2205	protein histidine kinase activity
BI380_RS15330	COG0583	DNA-binding transcription factor activity
BI380_RS15335	COG1444	tRNA N-acetyltransferase activity
BI380_RS15345	COG3383	formate dehydrogenase (NAD+) activity
BI380_RS15355	COG1846	Transcriptional regulator
BI380_RS15370	COG0477	Major facilitator Superfamily
BI380_RS15375	COG2010	Cytochrome c
BI380_RS15375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI380_RS15380	COG2080	2 iron, 2 sulfur cluster binding
BI380_RS15390	COG3473	Maleate cis-trans isomerase
BI380_RS15395	COG0596	Alpha beta hydrolase
BI380_RS15400	COG2309	aminopeptidase activity
BI380_RS15405	COG1335	isochorismatase
BI380_RS15410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI380_RS15410	COG2010	Cytochrome c
BI380_RS15415	COG0583	DNA-binding transcription factor activity
BI380_RS15425	COG0489	protein tyrosine kinase activity
BI380_RS15440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI380_RS15440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI380_RS15470	COG0602	queuosine metabolic process
BI380_RS15480	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BI380_RS15495	COG0156	8-amino-7-oxononanoate synthase activity
BI380_RS15535	COG1131	(ABC) transporter
BI380_RS15545	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BI380_RS15550	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BI380_RS15560	COG0583	DNA-binding transcription factor activity
BI380_RS15570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BI380_RS15575	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BI380_RS15580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BI380_RS15585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI380_RS15590	COG0588	phosphoglycerate mutase activity
BI380_RS15595	COG0793	Belongs to the peptidase S41A family
BI380_RS15600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BI380_RS15610	COG2197	response regulator
BI380_RS15620	COG5487	UPF0391 membrane protein
BI380_RS15640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BI380_RS15645	COG0742	ribosomal rna small subunit methyltransferase
BI380_RS15650	COG0612	Peptidase, M16
BI380_RS15655	COG0612	Peptidase, M16
BI380_RS15675	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS15680	COG1324	tolerance protein
BI380_RS15685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BI380_RS15715	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS15725	COG0300	oxidoreductase activity
BI380_RS15730	COG3971	2-oxopent-4-enoate hydratase activity
BI380_RS15735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BI380_RS15750	COG1464	Belongs to the NlpA lipoprotein family
BI380_RS15755	COG1464	Belongs to the NlpA lipoprotein family
BI380_RS15760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI380_RS15765	COG2011	ABC-type metal ion transport system permease component
BI380_RS15790	COG0431	NADPH-dependent FMN reductase
BI380_RS15805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI380_RS15810	COG2079	MmgE PrpD family protein
BI380_RS15815	COG1042	CoA-binding domain protein
BI380_RS15815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BI380_RS15815	COG0045	succinate-CoA ligase (ADP-forming) activity
BI380_RS15820	COG1024	Enoyl-CoA hydratase
BI380_RS15825	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS15835	COG0596	Alpha beta hydrolase
BI380_RS15845	COG0583	DNA-binding transcription factor activity
BI380_RS15855	COG3284	Transcriptional regulator
BI380_RS15865	COG1063	alcohol dehydrogenase
BI380_RS15870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI380_RS15875	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS15890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI380_RS15910	COG0840	transmembrane signaling receptor activity
BI380_RS15915	COG1999	signal sequence binding
BI380_RS15935	COG1845	cytochrome c oxidase, subunit III
BI380_RS15945	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BI380_RS15965	COG2226	methyltransferase
BI380_RS15970	COG1040	competence protein
BI380_RS15975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BI380_RS15990	COG1280	lysine exporter protein (LysE YggA)
BI380_RS16020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BI380_RS16155	COG0740	serine-type endopeptidase activity
BI380_RS16300	COG0582	viral genome integration into host DNA
BI380_RS16310	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS16320	COG2814	Major facilitator Superfamily
BI380_RS16325	COG2826	transposase and inactivated derivatives, IS30 family
BI380_RS16370	COG0625	glutathione transferase activity
BI380_RS16390	COG3300	MHYT domain
BI380_RS16390	COG5001	Diguanylate cyclase
BI380_RS16410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BI380_RS16415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI380_RS16440	COG1178	ABC-type Fe3 transport system permease component
BI380_RS16445	COG3842	ATPase activity
BI380_RS16475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BI380_RS16480	COG0540	Belongs to the ATCase OTCase family
BI380_RS16485	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BI380_RS16490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BI380_RS16495	COG1678	Uncharacterized ACR, COG1678
BI380_RS16500	COG0415	Belongs to the DNA photolyase family
BI380_RS16535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BI380_RS16540	COG2818	Glycosylase
BI380_RS16550	COG0138	bifunctional purine biosynthesis protein purh
BI380_RS16555	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BI380_RS16560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI380_RS16570	COG1238	metal cluster binding
BI380_RS16575	COG0583	DNA-binding transcription factor activity
BI380_RS16580	COG1741	Belongs to the pirin family
BI380_RS16595	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BI380_RS16605	COG4566	intracellular signal transduction
BI380_RS16625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI380_RS16635	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS16640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BI380_RS16655	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS16660	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS16740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BI380_RS16745	COG1111	helicase
BI380_RS16745	COG1205	dead DEAH box helicase
BI380_RS16755	COG0582	viral genome integration into host DNA
BI380_RS16760	COG0012	GTP binding
BI380_RS16765	COG0633	Ferredoxin
BI380_RS16765	COG3217	Mosc domain protein beta barrel domain protein
BI380_RS16770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI380_RS16775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI380_RS16785	COG1024	Enoyl-CoA hydratase
BI380_RS16820	COG2814	Major facilitator Superfamily
BI380_RS16850	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BI380_RS16855	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BI380_RS16865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI380_RS16890	COG0791	NLP P60 protein
BI380_RS16895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BI380_RS16905	COG2203	Gaf domain
BI380_RS16905	COG3706	GGDEF domain
BI380_RS16905	COG4251	negative regulation of phosphorylation
BI380_RS16905	COG5001	Diguanylate cyclase
BI380_RS16910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI380_RS16940	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI380_RS16950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI380_RS16960	COG2264	protein methyltransferase activity
BI380_RS16965	COG0439	Biotin carboxylase
BI380_RS16970	COG0511	ligase activity, forming carbon-carbon bonds
BI380_RS16975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI380_RS16985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI380_RS16995	COG3098	single-species biofilm formation
BI380_RS17000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BI380_RS17010	COG0312	modulator of DNA gyrase
BI380_RS17015	COG0772	Belongs to the SEDS family
BI380_RS17020	COG3150	esterase
BI380_RS17025	COG0557	exoribonuclease II activity
BI380_RS17035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BI380_RS17040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI380_RS17045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BI380_RS17050	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BI380_RS17065	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BI380_RS17070	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI380_RS17075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI380_RS17080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BI380_RS17085	COG0772	Belongs to the SEDS family
BI380_RS17090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BI380_RS17095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI380_RS17100	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BI380_RS17105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BI380_RS17120	COG0275	rRNA processing
BI380_RS17125	COG2001	Belongs to the MraZ family
BI380_RS17130	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BI380_RS17135	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BI380_RS17150	COG0523	cobalamin synthesis protein
BI380_RS17155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BI380_RS17165	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BI380_RS17170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI380_RS17180	COG3712	iron ion homeostasis
BI380_RS17195	COG4977	sequence-specific DNA binding
BI380_RS17230	COG1132	(ABC) transporter
BI380_RS17235	COG2188	Transcriptional regulator
BI380_RS17250	COG0114	fumarate hydratase activity
BI380_RS17260	COG2801	Transposase and inactivated derivatives
BI380_RS17260	COG3415	Transposase
BI380_RS17265	COG0405	Gamma-glutamyltransferase
BI380_RS17270	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BI380_RS17275	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI380_RS17280	COG1473	amidohydrolase
BI380_RS17325	COG3846	protein secretion by the type IV secretion system
BI380_RS17340	COG3451	type IV secretory pathway VirB4
BI380_RS17350	COG3838	Conjugal transfer protein Trbc
BI380_RS17355	COG4962	Type ii secretion system protein e
BI380_RS17370	COG0583	DNA-binding transcription factor activity
BI380_RS17410	COG2132	Multicopper oxidase
BI380_RS17445	COG1192	Involved in chromosome partitioning
BI380_RS17470	COG1396	sequence-specific DNA binding
BI380_RS17475	COG5489	Protein of unknown function (DUF736)
BI380_RS17500	COG1475	DNA binding
BI380_RS17530	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI380_RS17535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI380_RS17575	COG1968	undecaprenyl-diphosphatase activity
BI380_RS17605	COG0640	Transcriptional regulator
BI380_RS17620	COG0798	PFAM Bile acid sodium symporter
BI380_RS17630	COG0431	NADPH-dependent FMN reductase
BI380_RS17705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS17710	COG1024	Enoyl-CoA hydratase
BI380_RS17715	COG1960	acyl-CoA dehydrogenase activity
BI380_RS17720	COG1960	acyl-CoA dehydrogenase activity
BI380_RS17725	COG0183	Belongs to the thiolase family
BI380_RS17730	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI380_RS17730	COG1024	Enoyl-CoA hydratase
BI380_RS17735	COG0583	DNA-binding transcription factor activity
BI380_RS17755	COG0501	Belongs to the peptidase M48B family
BI380_RS17770	COG0418	dihydroorotase activity
BI380_RS17815	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS17820	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS17850	COG1126	abc transporter atp-binding protein
BI380_RS17855	COG0765	amino acid transport
BI380_RS17860	COG0765	amino acid transport
BI380_RS17870	COG0583	DNA-binding transcription factor activity
BI380_RS17875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BI380_RS17880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BI380_RS17880	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BI380_RS17885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI380_RS17900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI380_RS17940	COG5265	(ABC) transporter
BI380_RS17945	COG1607	acyl-coa hydrolase
BI380_RS17970	COG1024	Enoyl-CoA hydratase
BI380_RS17985	COG0183	Belongs to the thiolase family
BI380_RS17990	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI380_RS17990	COG1024	Enoyl-CoA hydratase
BI380_RS18000	COG1960	acyl-CoA dehydrogenase activity
BI380_RS18010	COG1309	transcriptional regulator
BI380_RS18015	COG0642	Histidine kinase
BI380_RS18020	COG0745	RESPONSE REGULATOR receiver
BI380_RS18025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BI380_RS18040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BI380_RS18055	COG2813	Specifically methylates the guanine in position
BI380_RS18075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI380_RS18090	COG1450	Type ii and iii secretion system protein
BI380_RS18115	COG4795	General secretion pathway protein
BI380_RS18135	COG1459	type II secretion system
BI380_RS18140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI380_RS18145	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BI380_RS18150	COG1652	LysM domain
BI380_RS18160	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS18185	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BI380_RS18190	COG0751	glycine-tRNA ligase activity
BI380_RS18195	COG0752	glycyl-tRNA synthetase alpha subunit
BI380_RS18200	COG4260	virion core protein, lumpy skin disease virus
BI380_RS18220	COG3842	ATPase activity
BI380_RS18225	COG1840	ABC-type Fe3 transport system, periplasmic component
BI380_RS18230	COG2186	Transcriptional regulator
BI380_RS18235	COG1953	Uracil, thiamine, allantoin
BI380_RS18240	COG0583	DNA-binding transcription factor activity
BI380_RS18270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI380_RS18275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BI380_RS18290	COG1522	sequence-specific DNA binding
BI380_RS18300	COG3186	Phenylalanine-4-hydroxylase
BI380_RS18310	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS18320	COG4774	siderophore transport
BI380_RS18325	COG3128	pkhd-type hydroxylase
BI380_RS18335	COG1196	nuclear chromosome segregation
BI380_RS18335	COG0739	heme binding
BI380_RS18335	COG0741	lytic transglycosylase activity
BI380_RS18340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BI380_RS18345	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BI380_RS18355	COG0617	tRNA 3'-terminal CCA addition
BI380_RS18360	COG5002	protein histidine kinase activity
BI380_RS18400	COG0037	tRNA processing
BI380_RS18415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI380_RS18420	COG0601	transmembrane transport
BI380_RS18425	COG0747	negative chemotaxis
BI380_RS18470	COG2255	four-way junction helicase activity
BI380_RS18475	COG0632	four-way junction helicase activity
BI380_RS18480	COG1702	phosphate starvation-inducible protein PhoH
BI380_RS18485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BI380_RS18490	COG0604	alcohol dehydrogenase
BI380_RS18505	COG0730	response to heat
BI380_RS18560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI380_RS18565	COG1490	D-aminoacyl-tRNA deacylase activity
BI380_RS18570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BI380_RS18580	COG4566	intracellular signal transduction
BI380_RS18595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BI380_RS18605	COG1131	(ABC) transporter
BI380_RS18610	COG0842	Transport permease protein
BI380_RS18620	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI380_RS18640	COG1846	Transcriptional regulator
BI380_RS18645	COG1764	response to oxidative stress
BI380_RS18660	COG5001	Diguanylate cyclase
BI380_RS18660	COG4251	negative regulation of phosphorylation
BI380_RS18660	COG3706	GGDEF domain
BI380_RS18660	COG2203	Gaf domain
BI380_RS18685	COG2814	Major facilitator Superfamily
BI380_RS18690	COG0829	nickel cation binding
BI380_RS18695	COG0831	urea catabolic process
BI380_RS18705	COG0832	Belongs to the urease beta subunit family
BI380_RS18710	COG0804	urea catabolic process
BI380_RS18725	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BI380_RS18730	COG0830	nickel cation binding
BI380_RS18735	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BI380_RS18755	COG0326	Molecular chaperone. Has ATPase activity
BI380_RS18760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BI380_RS18765	COG4774	siderophore transport
BI380_RS18770	COG3128	pkhd-type hydroxylase
BI380_RS18780	COG3712	iron ion homeostasis
BI380_RS18785	COG1595	DNA-templated transcription, initiation
BI380_RS18790	COG4774	siderophore transport
BI380_RS18795	COG3712	iron ion homeostasis
BI380_RS18800	COG1595	DNA-templated transcription, initiation
BI380_RS18805	COG1187	pseudouridine synthase activity
BI380_RS18825	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS18830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS18845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI380_RS18850	COG1022	Amp-dependent synthetase and ligase
BI380_RS18860	COG0559	Belongs to the binding-protein-dependent transport system permease family
BI380_RS18900	COG0667	Aldo Keto reductase
BI380_RS18910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI380_RS18930	COG0745	RESPONSE REGULATOR receiver
BI380_RS18935	COG2194	sulfuric ester hydrolase activity
BI380_RS18945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI380_RS18950	COG1116	anion transmembrane transporter activity
BI380_RS18965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI380_RS18980	COG3842	ATPase activity
BI380_RS18985	COG1473	amidohydrolase
BI380_RS18995	COG0243	molybdopterin cofactor binding
BI380_RS19035	COG2814	Major facilitator Superfamily
BI380_RS19040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BI380_RS19045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BI380_RS19050	COG0277	FAD linked oxidase domain protein
BI380_RS19055	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BI380_RS19065	COG3945	hemerythrin HHE cation binding domain
BI380_RS19085	COG0288	reversible hydration of carbon dioxide
BI380_RS19090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI380_RS19095	COG2181	nitrate reductase activity
BI380_RS19100	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BI380_RS19105	COG1140	nitrate reductase beta subunit
BI380_RS19110	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BI380_RS19115	COG2223	nitrite transmembrane transporter activity
BI380_RS19145	COG2197	response regulator
BI380_RS19150	COG4585	Histidine kinase
BI380_RS19170	COG0583	DNA-binding transcription factor activity
BI380_RS19175	COG0277	FAD linked oxidase domain protein
BI380_RS19200	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BI380_RS19230	COG5002	protein histidine kinase activity
BI380_RS19245	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BI380_RS19250	COG0439	Biotin carboxylase
BI380_RS19265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BI380_RS19280	COG4607	ABC-type enterochelin transport system periplasmic component
BI380_RS19285	COG4771	TonB-dependent receptor
BI380_RS19290	COG2733	membrane
BI380_RS19300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BI380_RS19300	COG1017	nitric oxide dioxygenase activity
BI380_RS19310	COG3177	Filamentation induced by cAMP protein fic
BI380_RS19320	COG0545	Peptidyl-prolyl cis-trans isomerase
BI380_RS19330	COG4770	biotin carboxylase activity
BI380_RS19335	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS19350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BI380_RS19360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI380_RS19370	COG2084	Dehydrogenase
BI380_RS19375	COG2823	Periplasmic or secreted lipoprotein
BI380_RS19380	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BI380_RS19385	COG0792	nuclease activity
BI380_RS19390	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BI380_RS19395	COG0443	Heat shock 70 kDa protein
BI380_RS19420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI380_RS19425	COG4172	Belongs to the ABC transporter superfamily
BI380_RS19430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI380_RS19445	COG0471	metal ion transport
BI380_RS19460	COG0203	ribosomal protein L17
BI380_RS19465	COG0202	RNA polymerase activity
BI380_RS19470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BI380_RS19475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BI380_RS19480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BI380_RS19485	COG0201	protein transport
BI380_RS19490	COG0200	Binds to the 23S rRNA
BI380_RS19495	COG1841	ribosomal large subunit assembly
BI380_RS19500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BI380_RS19505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BI380_RS19510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BI380_RS19515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BI380_RS19520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BI380_RS19525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BI380_RS19530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BI380_RS19535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BI380_RS19540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BI380_RS19555	COG0395	ABC-type sugar transport system, permease component
BI380_RS19565	COG3842	ATPase activity
BI380_RS19570	COG3842	ATPase activity
BI380_RS19580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BI380_RS19595	COG0028	Belongs to the TPP enzyme family
BI380_RS19600	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS19615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BI380_RS19620	COG0671	phosphoesterase, PA-phosphatase related
BI380_RS19625	COG0783	Belongs to the Dps family
BI380_RS19640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI380_RS19650	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BI380_RS19655	COG4604	ABC transporter, ATP-binding protein
BI380_RS19660	COG4605	iron ion homeostasis
BI380_RS19665	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI380_RS19670	COG4607	ABC-type enterochelin transport system periplasmic component
BI380_RS19685	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BI380_RS19695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BI380_RS19700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BI380_RS19705	COG0693	protein deglycase activity
BI380_RS19720	COG0583	DNA-binding transcription factor activity
BI380_RS19730	COG3118	belongs to the thioredoxin family
BI380_RS19735	COG3842	ATPase activity
BI380_RS19745	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BI380_RS19750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BI380_RS19755	COG0009	L-threonylcarbamoyladenylate synthase
BI380_RS19770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI380_RS19775	COG3718	enzyme involved in inositol metabolism
BI380_RS19815	COG1214	PFAM Peptidase M22, glycoprotease
BI380_RS19820	COG0456	acetyltransferase
BI380_RS19830	COG0598	Magnesium transport protein CorA
BI380_RS19855	COG0583	DNA-binding transcription factor activity
BI380_RS19885	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS19895	COG1012	belongs to the aldehyde dehydrogenase family
BI380_RS19910	COG1414	Transcriptional regulator
BI380_RS19935	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
BI380_RS19940	COG1414	Transcriptional regulator
BI380_RS19960	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BI380_RS19965	COG1309	transcriptional regulator
BI380_RS19970	COG1522	sequence-specific DNA binding
BI380_RS19985	COG0656	L-ascorbic acid biosynthetic process
BI380_RS19990	COG0583	DNA-binding transcription factor activity
BI380_RS19995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI380_RS20000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BI380_RS20005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BI380_RS20040	COG0671	phosphoesterase, PA-phosphatase related
BI380_RS20045	COG0469	pyruvate kinase activity
BI380_RS20060	COG0006	proline dipeptidase activity
BI380_RS20065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI380_RS20070	COG0640	Transcriptional regulator
BI380_RS20105	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BI380_RS20110	COG0583	DNA-binding transcription factor activity
BI380_RS20130	COG0583	DNA-binding transcription factor activity
BI380_RS20135	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS20140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BI380_RS20155	COG0625	glutathione transferase activity
BI380_RS20165	COG3550	peptidyl-serine autophosphorylation
BI380_RS20175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BI380_RS20175	COG2755	lipolytic protein G-D-S-L family
BI380_RS20180	COG3148	PFAM DTW domain containing protein
BI380_RS20195	COG0420	3'-5' exonuclease activity
BI380_RS20200	COG0419	ATPase involved in DNA repair
BI380_RS20225	COG0386	Belongs to the glutathione peroxidase family
BI380_RS20235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI380_RS20245	COG2365	Tyrosine phosphatase family
BI380_RS20285	COG0642	Histidine kinase
BI380_RS20300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BI380_RS20305	COG2137	regulation of response to DNA damage stimulus
BI380_RS20310	COG0697	spore germination
BI380_RS20320	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BI380_RS20325	COG0045	succinate-CoA ligase (ADP-forming) activity
BI380_RS20330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BI380_RS20335	COG0861	Integral membrane protein TerC family
BI380_RS20340	COG0631	protein serine/threonine phosphatase activity
BI380_RS20375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BI380_RS20375	COG0546	phosphoglycolate phosphatase activity
BI380_RS20385	COG0315	cyclic pyranopterin monophosphate synthase activity
BI380_RS20390	COG4783	chaperone-mediated protein folding
BI380_RS20395	COG1950	PFAM Membrane protein of
BI380_RS20405	COG0861	Integral membrane protein TerC family
BI380_RS20435	COG0625	glutathione transferase activity
BI380_RS20440	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BI380_RS20470	COG2885	chlorophyll binding
BI380_RS20475	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BI380_RS20480	COG2814	Major facilitator Superfamily
BI380_RS20485	COG1522	sequence-specific DNA binding
BI380_RS20495	COG1862	Preprotein translocase
BI380_RS20500	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BI380_RS20505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BI380_RS20515	COG0758	DNA mediated transformation
BI380_RS20525	COG0242	peptide deformylase activity
BI380_RS20535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BI380_RS20550	COG0126	phosphoglycerate kinase activity
BI380_RS20570	COG0284	orotidine-5'-phosphate decarboxylase activity
BI380_RS20575	COG0583	DNA-binding transcription factor activity
BI380_RS20600	COG2814	Major facilitator Superfamily
BI380_RS20605	COG0629	single-stranded DNA binding
BI380_RS20615	COG0659	secondary active sulfate transmembrane transporter activity
BI380_RS20630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BI380_RS20635	COG2151	metal-sulfur cluster biosynthetic enzyme
BI380_RS20640	COG3396	Phenylacetate-CoA oxygenase
BI380_RS20645	COG3460	Phenylacetate-CoA oxygenase
BI380_RS20650	COG3396	Phenylacetate-CoA oxygenase
BI380_RS20660	COG1012	belongs to the aldehyde dehydrogenase family
BI380_RS20665	COG1309	transcriptional regulator
BI380_RS20675	COG4585	Histidine kinase
BI380_RS20685	COG0482	sulfurtransferase activity
BI380_RS20690	COG0583	DNA-binding transcription factor activity
BI380_RS20695	COG1024	Enoyl-CoA hydratase
BI380_RS20705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS20715	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS20735	COG3976	FMN-binding domain protein
BI380_RS20735	COG1053	succinate dehydrogenase
BI380_RS20750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BI380_RS20790	COG1129	ABC transporter
BI380_RS20800	COG1172	Belongs to the binding-protein-dependent transport system permease family
BI380_RS20810	COG1072	(Pantothenic acid kinase))
BI380_RS20835	COG0583	DNA-binding transcription factor activity
BI380_RS20855	COG2015	COG2015, Alkyl sulfatase and related hydrolases
BI380_RS20860	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BI380_RS20875	COG0134	indole-3-glycerol-phosphate synthase activity
BI380_RS20880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BI380_RS20885	COG0512	Glutamine amidotransferase of anthranilate synthase
BI380_RS20915	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BI380_RS20925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI380_RS20930	COG0842	Transport permease protein
BI380_RS20930	COG1129	ABC transporter
BI380_RS20935	COG0842	Transport permease protein
BI380_RS20980	COG3621	Patatin-like phospholipase
BI380_RS20990	COG0642	Histidine kinase
BI380_RS21010	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BI380_RS21015	COG0546	phosphoglycolate phosphatase activity
BI380_RS21020	COG0840	transmembrane signaling receptor activity
BI380_RS21025	COG0835	chemotaxis
BI380_RS21030	COG0840	transmembrane signaling receptor activity
BI380_RS21040	COG0745	RESPONSE REGULATOR receiver
BI380_RS21045	COG0784	Response regulator, receiver
BI380_RS21045	COG3437	response regulator, receiver
BI380_RS21050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BI380_RS21055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BI380_RS21055	COG2205	protein histidine kinase activity
BI380_RS21065	COG0583	DNA-binding transcription factor activity
BI380_RS21070	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS21075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI380_RS21085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BI380_RS21090	COG3959	Transketolase, thiamine diphosphate binding domain
BI380_RS21095	COG3958	Transketolase
BI380_RS21125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BI380_RS21130	COG2967	ApaG domain
BI380_RS21145	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BI380_RS21170	COG0583	DNA-binding transcription factor activity
BI380_RS21185	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BI380_RS21200	COG0653	protein targeting
BI380_RS21245	COG1960	acyl-CoA dehydrogenase activity
BI380_RS21255	COG0183	Belongs to the thiolase family
BI380_RS21270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS21300	COG0456	acetyltransferase
BI380_RS21305	COG2076	Multidrug Resistance protein
BI380_RS21320	COG2423	ornithine cyclodeaminase activity
BI380_RS21325	COG0010	Belongs to the arginase family
BI380_RS21335	COG3541	Predicted nucleotidyltransferase
BI380_RS21340	COG1690	Belongs to the RtcB family
BI380_RS21355	COG4650	regulator
BI380_RS21360	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BI380_RS21365	COG1137	ATPase activity
BI380_RS21370	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BI380_RS21375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI380_RS21380	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BI380_RS21385	COG0018	arginyl-trna synthetase
BI380_RS21405	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BI380_RS21410	COG1942	4-Oxalocrotonate Tautomerase
BI380_RS21420	COG0121	glutamine amidotransferase
BI380_RS21475	COG0189	ligase activity
BI380_RS21480	COG3135	benzoate transporter
BI380_RS21485	COG3158	transport of potassium into the cell
BI380_RS21495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BI380_RS21500	COG0569	domain protein
BI380_RS21505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BI380_RS21525	COG0495	leucyl-tRNA aminoacylation
BI380_RS21530	COG0668	transmembrane transport
BI380_RS21545	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BI380_RS21550	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI380_RS21555	COG0735	belongs to the Fur family
BI380_RS21570	COG1595	DNA-templated transcription, initiation
BI380_RS21585	COG3437	response regulator, receiver
BI380_RS21610	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS21625	COG0559	Belongs to the binding-protein-dependent transport system permease family
BI380_RS21630	COG4177	L-phenylalanine transmembrane transporter activity
BI380_RS21655	COG0281	malic enzyme
BI380_RS21655	COG0280	phosphate acetyltransferase
BI380_RS21670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BI380_RS21675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI380_RS21680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BI380_RS21690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BI380_RS21710	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI380_RS21715	COG0584	glycerophosphoryl diester phosphodiesterase
BI380_RS21720	COG2813	Specifically methylates the guanine in position
BI380_RS21720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI380_RS21725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI380_RS21730	COG2119	membrane
BI380_RS21735	COG0724	RNA recognition motif
BI380_RS21745	COG0300	oxidoreductase activity
BI380_RS21760	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BI380_RS21760	COG0517	IMP dehydrogenase activity
BI380_RS21765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI380_RS21780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BI380_RS21785	COG0706	membrane insertase activity
BI380_RS21795	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BI380_RS21800	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BI380_RS21840	COG2205	protein histidine kinase activity
BI380_RS21865	COG1199	ATP-dependent helicase activity
BI380_RS21880	COG2974	May be involved in recombination
BI380_RS21885	COG0183	Belongs to the thiolase family
BI380_RS21890	COG1024	Enoyl-CoA hydratase
BI380_RS21895	COG1022	Amp-dependent synthetase and ligase
BI380_RS21945	COG1902	pentaerythritol trinitrate reductase activity
BI380_RS21965	COG0445	tRNA wobble uridine modification
BI380_RS21970	COG0357	Ribosomal RNA small subunit methyltransferase G
BI380_RS21975	COG1280	lysine exporter protein (LysE YggA)
BI380_RS21980	COG1192	Involved in chromosome partitioning
BI380_RS21990	COG1475	DNA binding
BI380_RS22045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS22055	COG0277	FAD linked oxidase domain protein
BI380_RS22065	COG2096	Adenosyltransferase
BI380_RS22075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI380_RS22080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BI380_RS22105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BI380_RS22105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BI380_RS22150	COG2050	protein possibly involved in aromatic compounds catabolism
BI380_RS22160	COG2233	PERMEase
BI380_RS22165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BI380_RS22170	COG1960	acyl-CoA dehydrogenase activity
BI380_RS22175	COG1960	acyl-CoA dehydrogenase activity
BI380_RS22185	COG0850	regulation of cytokinetic process
BI380_RS22195	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BI380_RS22225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BI380_RS22230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI380_RS22230	COG1199	ATP-dependent helicase activity
BI380_RS22235	COG1846	Transcriptional regulator
BI380_RS22250	COG3971	2-oxopent-4-enoate hydratase activity
BI380_RS22270	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS22275	COG1012	belongs to the aldehyde dehydrogenase family
BI380_RS22285	COG0179	Fumarylacetoacetate (FAA) hydrolase
BI380_RS22315	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BI380_RS22320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BI380_RS22340	COG1960	acyl-CoA dehydrogenase activity
BI380_RS22355	COG0745	RESPONSE REGULATOR receiver
BI380_RS22405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BI380_RS22420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BI380_RS22450	COG0514	ATP-dependent DNA helicase (RecQ)
BI380_RS22460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS22475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI380_RS22485	COG2188	Transcriptional regulator
BI380_RS22490	COG2986	histidine ammonia-lyase
BI380_RS22495	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BI380_RS22505	COG1228	amidohydrolase
BI380_RS22510	COG0277	FAD linked oxidase domain protein
BI380_RS22530	COG0789	Transcriptional regulator
BI380_RS22560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI380_RS22570	COG1538	Outer membrane efflux protein
BI380_RS22580	COG3949	Membrane
BI380_RS22610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS22615	COG0583	DNA-binding transcription factor activity
BI380_RS22625	COG1960	acyl-CoA dehydrogenase activity
BI380_RS22660	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BI380_RS22665	COG0154	amidase activity
BI380_RS22680	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS22715	COG0183	Belongs to the thiolase family
BI380_RS22720	COG0427	acetyl-CoA hydrolase
BI380_RS22725	COG1024	Enoyl-CoA hydratase
BI380_RS22730	COG2030	dehydratase
BI380_RS22735	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS22740	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
BI380_RS22745	COG1960	acyl-CoA dehydrogenase activity
BI380_RS22770	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS22790	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS22795	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS22800	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BI380_RS22805	COG3971	2-oxopent-4-enoate hydratase activity
BI380_RS22810	COG2326	polyphosphate kinase activity
BI380_RS22825	COG0583	DNA-binding transcription factor activity
BI380_RS22840	COG2205	protein histidine kinase activity
BI380_RS22840	COG0784	Response regulator, receiver
BI380_RS22840	COG2198	Histidine kinase
BI380_RS22880	COG1126	abc transporter atp-binding protein
BI380_RS22885	COG0765	amino acid transport
BI380_RS22890	COG0765	amino acid transport
BI380_RS22900	COG2186	Transcriptional regulator
BI380_RS22905	COG1410	methionine synthase
BI380_RS22905	COG0646	methionine synthase
BI380_RS22910	COG0584	glycerophosphoryl diester phosphodiesterase
BI380_RS22915	COG2186	Transcriptional regulator
BI380_RS22920	COG1301	dicarboxylic acid transport
BI380_RS22930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI380_RS22950	COG2824	Alkylphosphonate utilization operon protein PhnA
BI380_RS22965	COG0583	DNA-binding transcription factor activity
BI380_RS22975	COG1346	cytolysis
BI380_RS22985	COG1012	belongs to the aldehyde dehydrogenase family
BI380_RS22995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI380_RS23000	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS23005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI380_RS23010	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS23015	COG2186	Transcriptional regulator
BI380_RS23020	COG4948	Mandelate Racemase Muconate Lactonizing
BI380_RS23025	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS23030	COG2721	sulfolactate sulfo-lyase activity
BI380_RS23040	COG0583	DNA-binding transcription factor activity
BI380_RS23080	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS23095	COG0583	DNA-binding transcription factor activity
BI380_RS23100	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS23120	COG0583	DNA-binding transcription factor activity
BI380_RS23135	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS23155	COG0583	DNA-binding transcription factor activity
BI380_RS23160	COG3550	peptidyl-serine autophosphorylation
BI380_RS23165	COG1396	sequence-specific DNA binding
BI380_RS23170	COG0606	chelatase, subunit chli
BI380_RS23205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BI380_RS23235	COG0784	Response regulator, receiver
BI380_RS23235	COG2205	protein histidine kinase activity
BI380_RS23240	COG1063	alcohol dehydrogenase
BI380_RS23290	COG1396	sequence-specific DNA binding
BI380_RS23320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS23335	COG2271	Major facilitator Superfamily
BI380_RS23340	COG4948	Mandelate Racemase Muconate Lactonizing
BI380_RS23350	COG1012	belongs to the aldehyde dehydrogenase family
BI380_RS23355	COG2267	carboxylic ester hydrolase activity
BI380_RS23365	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS23370	COG3119	arylsulfatase activity
BI380_RS23385	COG3209	COG3209 Rhs family protein
BI380_RS23400	COG0347	Belongs to the P(II) protein family
BI380_RS23405	COG0004	ammonium transporteR
BI380_RS23410	COG0277	FAD linked oxidase domain protein
BI380_RS23420	COG0247	lactate metabolic process
BI380_RS23440	COG0477	Major facilitator Superfamily
BI380_RS23445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BI380_RS23500	COG1442	glycosyl transferase family 8
BI380_RS23500	COG1216	Glycosyl transferase, family 2
BI380_RS23515	COG2814	Major facilitator Superfamily
BI380_RS23520	COG0583	DNA-binding transcription factor activity
BI380_RS23530	COG2205	protein histidine kinase activity
BI380_RS23540	COG2211	Major facilitator Superfamily
BI380_RS23565	COG2175	clavaminate synthase activity
BI380_RS23570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI380_RS23590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI380_RS23630	COG0708	Exodeoxyribonuclease III
BI380_RS23635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BI380_RS23645	COG4993	Dehydrogenase
BI380_RS23670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI380_RS23685	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BI380_RS23690	COG0154	amidase activity
BI380_RS23695	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BI380_RS23700	COG1077	Cell shape determining protein MreB Mrl
BI380_RS23705	COG1792	Involved in formation and maintenance of cell shape
BI380_RS23715	COG0768	penicillin binding
BI380_RS23735	COG0765	amino acid transport
BI380_RS23755	COG0583	DNA-binding transcription factor activity
BI380_RS23765	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI380_RS23770	COG1127	ABC transporter
BI380_RS23785	COG3237	CsbD-like
BI380_RS23795	COG2703	oxygen carrier activity
BI380_RS23800	COG2095	MarC family integral membrane protein
BI380_RS23805	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS23810	COG0412	Dienelactone hydrolase
BI380_RS23840	COG2197	response regulator
BI380_RS23850	COG0598	Magnesium transport protein CorA
BI380_RS23860	COG1981	membrane
BI380_RS23870	COG3411	Ferredoxin
BI380_RS23875	COG2945	thiolester hydrolase activity
BI380_RS23880	COG1686	Belongs to the peptidase S11 family
BI380_RS23885	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BI380_RS23890	COG0049	tRNA binding
BI380_RS23895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BI380_RS23900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI380_RS23905	COG0051	transcription antitermination factor activity, RNA binding
BI380_RS23910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BI380_RS23915	COG0088	Forms part of the polypeptide exit tunnel
BI380_RS23920	COG0089	rRNA binding
BI380_RS23925	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BI380_RS23930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BI380_RS23935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BI380_RS23940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BI380_RS23945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BI380_RS23950	COG0255	Belongs to the universal ribosomal protein uL29 family
BI380_RS23955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BI380_RS23960	COG0678	peroxiredoxin activity
BI380_RS23975	COG3909	cytochrome
BI380_RS23980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI380_RS23995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI380_RS24000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI380_RS24015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BI380_RS24020	COG0321	lipoyl(octanoyl) transferase activity
BI380_RS24025	COG2921	Belongs to the UPF0250 family
BI380_RS24035	COG0356	it plays a direct role in the translocation of protons across the membrane
BI380_RS24050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BI380_RS24060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BI380_RS24065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BI380_RS24070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BI380_RS24120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI380_RS24150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI380_RS24160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BI380_RS24170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BI380_RS24175	COG0081	regulation of translation
BI380_RS24180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BI380_RS24185	COG0222	ribosome binding
BI380_RS24190	COG0085	RNA polymerase activity
BI380_RS24195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BI380_RS24215	COG5000	phosphorelay sensor kinase activity
BI380_RS24220	COG2204	response regulator
BI380_RS24240	COG1959	2 iron, 2 sulfur cluster binding
BI380_RS24250	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BI380_RS24255	COG1074	ATP-dependent DNA helicase activity
BI380_RS24260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BI380_RS24265	COG0625	glutathione transferase activity
BI380_RS24290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI380_RS24310	COG2072	flavoprotein involved in K transport
BI380_RS24315	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS24335	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS24335	COG0204	Acyl-transferase
BI380_RS24395	COG0343	queuine tRNA-ribosyltransferase activity
BI380_RS24420	COG0210	DNA helicase
BI380_RS24445	COG0679	Auxin Efflux Carrier
BI380_RS24475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BI380_RS24480	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BI380_RS24490	COG1024	Enoyl-CoA hydratase
BI380_RS24495	COG2050	protein possibly involved in aromatic compounds catabolism
BI380_RS24540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI380_RS24550	COG1414	Transcriptional regulator
BI380_RS24555	COG0840	transmembrane signaling receptor activity
BI380_RS24565	COG1832	CoA-binding protein
BI380_RS24570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BI380_RS24585	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS24595	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS24610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS24620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS24625	COG1191	sigma factor activity
BI380_RS24640	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI380_RS24650	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BI380_RS24655	COG0745	RESPONSE REGULATOR receiver
BI380_RS24670	COG0457	Tetratricopeptide repeat
BI380_RS24670	COG0463	Glycosyl transferase, family 2
BI380_RS24705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI380_RS24715	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BI380_RS24735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI380_RS24750	COG1706	bacterial-type flagellum-dependent cell motility
BI380_RS24755	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BI380_RS24760	COG4786	Flagellar basal body rod
BI380_RS24775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BI380_RS24780	COG1558	bacterial-type flagellum-dependent cell motility
BI380_RS24785	COG1815	bacterial-type flagellum-dependent cell motility
BI380_RS24790	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
BI380_RS24810	COG1766	The M ring may be actively involved in energy transduction
BI380_RS24825	COG1157	protein secretion by the type III secretion system
BI380_RS24850	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BI380_RS24875	COG2197	response regulator
BI380_RS24890	COG0745	RESPONSE REGULATOR receiver
BI380_RS24895	COG2198	Histidine kinase
BI380_RS24895	COG0643	Histidine kinase
BI380_RS24905	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI380_RS24910	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BI380_RS24915	COG2201	protein-glutamate methylesterase activity
BI380_RS24920	COG0488	(ABC) transporter
BI380_RS24985	COG1960	acyl-CoA dehydrogenase activity
BI380_RS24990	COG0288	reversible hydration of carbon dioxide
BI380_RS24995	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BI380_RS25000	COG0183	Belongs to the thiolase family
BI380_RS25015	COG1960	acyl-CoA dehydrogenase activity
BI380_RS25020	COG2267	carboxylic ester hydrolase activity
BI380_RS25030	COG3012	SEC-C Motif Domain Protein
BI380_RS25035	COG2198	Histidine kinase
BI380_RS25035	COG2205	protein histidine kinase activity
BI380_RS25035	COG0784	Response regulator, receiver
BI380_RS25050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI380_RS25065	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS25070	COG0025	NhaP-type Na H and K H
BI380_RS25075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BI380_RS25080	COG1024	Enoyl-CoA hydratase
BI380_RS25095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI380_RS25105	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI380_RS25110	COG0583	DNA-binding transcription factor activity
BI380_RS25145	COG2207	Transcriptional regulator
BI380_RS25155	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI380_RS25160	COG3162	membrane
BI380_RS25165	COG0477	Major facilitator Superfamily
BI380_RS25175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BI380_RS25180	COG2814	Major facilitator Superfamily
BI380_RS25185	COG0583	DNA-binding transcription factor activity
BI380_RS25195	COG0477	Major facilitator Superfamily
BI380_RS25200	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BI380_RS25205	COG1414	Transcriptional regulator
BI380_RS25210	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BI380_RS25220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI380_RS25235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI380_RS25240	COG0506	proline dehydrogenase activity
BI380_RS25240	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BI380_RS25240	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BI380_RS25255	COG3188	usher protein
BI380_RS25260	COG3121	Chaperone
BI380_RS25285	COG2076	Multidrug Resistance protein
BI380_RS25290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BI380_RS25305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BI380_RS25325	COG2205	protein histidine kinase activity
BI380_RS25330	COG0745	RESPONSE REGULATOR receiver
BI380_RS25335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BI380_RS25345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI380_RS25350	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BI380_RS25355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BI380_RS25360	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BI380_RS25365	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BI380_RS25370	COG0316	Belongs to the HesB IscA family
BI380_RS25375	COG2814	Major facilitator Superfamily
BI380_RS25385	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI380_RS25390	COG2252	PERMEase
BI380_RS25395	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BI380_RS25400	COG0739	heme binding
BI380_RS25405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BI380_RS25410	COG0583	DNA-binding transcription factor activity
BI380_RS25415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BI380_RS25425	COG3706	GGDEF domain
BI380_RS25430	COG1522	sequence-specific DNA binding
BI380_RS25540	COG1815	bacterial-type flagellum-dependent cell motility
BI380_RS25605	COG2814	Major facilitator Superfamily
BI380_RS25655	COG3712	iron ion homeostasis
BI380_RS25660	COG1595	DNA-templated transcription, initiation
BI380_RS25665	COG1309	transcriptional regulator
BI380_RS25680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI380_RS25710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS25725	COG2318	DinB family
BI380_RS25750	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BI380_RS25775	COG3800	Transcriptional regulator
BI380_RS25775	COG1396	sequence-specific DNA binding
BI380_RS25795	COG0583	DNA-binding transcription factor activity
BI380_RS25805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI380_RS25810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI380_RS25825	COG3712	iron ion homeostasis
BI380_RS25830	COG0840	transmembrane signaling receptor activity
BI380_RS25855	COG2099	Precorrin-6x reductase
BI380_RS25870	COG2875	Belongs to the precorrin methyltransferase family
BI380_RS25885	COG0038	chloride channel
BI380_RS25890	COG1285	pathogenesis
BI380_RS25935	COG0129	dihydroxy-acid dehydratase activity
BI380_RS25940	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS25965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI380_RS25970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI380_RS25980	COG2197	response regulator
BI380_RS26010	COG0346	lactoylglutathione lyase activity
BI380_RS26015	COG0475	glutathione-regulated potassium exporter activity
BI380_RS26015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI380_RS26020	COG4555	ABC transporter
BI380_RS26065	COG0456	acetyltransferase
BI380_RS26070	COG0583	DNA-binding transcription factor activity
BI380_RS26080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI380_RS26085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI380_RS26090	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS26105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BI380_RS26110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI380_RS26120	COG1045	serine acetyltransferase
BI380_RS26130	COG1914	H( )-stimulated, divalent metal cation uptake system
BI380_RS26145	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BI380_RS26190	COG1126	abc transporter atp-binding protein
BI380_RS26195	COG0765	amino acid transport
BI380_RS26200	COG0765	amino acid transport
BI380_RS26205	COG0436	Aminotransferase
BI380_RS26210	COG0277	FAD linked oxidase domain protein
BI380_RS26240	COG1397	ADP-ribosylglycohydrolase
BI380_RS26280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BI380_RS26290	COG4771	TonB-dependent receptor
BI380_RS26300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI380_RS26305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BI380_RS26310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI380_RS26340	COG0745	RESPONSE REGULATOR receiver
BI380_RS26345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI380_RS26350	COG0488	(ABC) transporter
BI380_RS26360	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
BI380_RS26370	COG2259	Doxx family
BI380_RS26375	COG1802	Transcriptional regulator
BI380_RS26405	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BI380_RS26410	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BI380_RS26415	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BI380_RS26420	COG4770	biotin carboxylase activity
BI380_RS26425	COG0737	Belongs to the 5'-nucleotidase family
BI380_RS26435	COG0307	riboflavin synthase, alpha
BI380_RS26450	COG0443	Heat shock 70 kDa protein
BI380_RS26455	COG0443	Heat shock 70 kDa protein
BI380_RS26490	COG0583	DNA-binding transcription factor activity
BI380_RS26495	COG3045	CreA protein
BI380_RS26500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BI380_RS26500	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI380_RS26505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BI380_RS26505	COG0189	ligase activity
BI380_RS26510	COG1132	(ABC) transporter
BI380_RS26540	COG0625	glutathione transferase activity
BI380_RS26550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI380_RS26620	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BI380_RS26625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BI380_RS26630	COG1765	OsmC-like protein
BI380_RS26635	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BI380_RS26650	COG1473	amidohydrolase
BI380_RS26660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BI380_RS26670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BI380_RS26675	COG0166	Belongs to the GPI family
BI380_RS26680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BI380_RS26685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS26700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI380_RS26705	COG0444	Belongs to the ABC transporter superfamily
BI380_RS26710	COG4608	Belongs to the ABC transporter superfamily
BI380_RS26715	COG1228	amidohydrolase
BI380_RS26720	COG0523	cobalamin synthesis protein
BI380_RS26730	COG5383	Protein conserved in bacteria
BI380_RS26735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS26740	COG0459	protein refolding
BI380_RS26745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BI380_RS26750	COG1595	DNA-templated transcription, initiation
BI380_RS26770	COG0346	lactoylglutathione lyase activity
BI380_RS26790	COG1309	transcriptional regulator
BI380_RS26825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BI380_RS26835	COG1012	belongs to the aldehyde dehydrogenase family
BI380_RS26840	COG3284	Transcriptional regulator
BI380_RS26855	COG1414	Transcriptional regulator
BI380_RS26890	COG0251	oxidation-reduction process
BI380_RS26900	COG0179	Fumarylacetoacetate (FAA) hydrolase
BI380_RS26920	COG0523	cobalamin synthesis protein
BI380_RS26925	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS26940	COG0583	DNA-binding transcription factor activity
BI380_RS26950	COG0583	DNA-binding transcription factor activity
BI380_RS26980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI380_RS26980	COG1116	anion transmembrane transporter activity
BI380_RS26990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI380_RS26995	COG2873	o-acetylhomoserine
BI380_RS27015	COG2011	ABC-type metal ion transport system permease component
BI380_RS27025	COG0583	DNA-binding transcription factor activity
BI380_RS27035	COG1056	cytidyltransferase-related domain
BI380_RS27035	COG1051	belongs to the nudix hydrolase family
BI380_RS27040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BI380_RS27040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI380_RS27045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BI380_RS27080	COG1216	Glycosyl transferase, family 2
BI380_RS27090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BI380_RS27100	COG1560	Kdo2-lipid A biosynthetic process
BI380_RS27105	COG2267	carboxylic ester hydrolase activity
BI380_RS27110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BI380_RS27115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI380_RS27120	COG0166	Belongs to the GPI family
BI380_RS27135	COG1175	transmembrane transport
BI380_RS27140	COG0395	ABC-type sugar transport system, permease component
BI380_RS27150	COG0246	Mannitol dehydrogenase
BI380_RS27160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BI380_RS27160	COG2207	Transcriptional regulator
BI380_RS27170	COG1333	cytochrome c biogenesis protein
BI380_RS27175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI380_RS27180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BI380_RS27185	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BI380_RS27200	COG1965	Belongs to the frataxin family
BI380_RS27240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BI380_RS27250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BI380_RS27270	COG1234	tRNA 3'-trailer cleavage
BI380_RS27295	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS27300	COG0183	Belongs to the thiolase family
BI380_RS27305	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BI380_RS27315	COG1414	Transcriptional regulator
BI380_RS27325	COG0069	glutamate synthase activity
BI380_RS27325	COG0070	glutamate synthase
BI380_RS27325	COG0067	glutamate synthase
BI380_RS27335	COG0805	protein transport
BI380_RS27340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI380_RS27345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI380_RS27350	COG0537	adenosine 5'-monophosphoramidase activity
BI380_RS27365	COG0140	phosphoribosyl-ATP diphosphatase activity
BI380_RS27370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BI380_RS27375	COG0107	imidazoleglycerol-phosphate synthase activity
BI380_RS27380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BI380_RS27410	COG0438	transferase activity, transferring glycosyl groups
BI380_RS27425	COG0765	amino acid transport
BI380_RS27430	COG1126	abc transporter atp-binding protein
BI380_RS27435	COG1127	ABC transporter
BI380_RS27440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI380_RS27445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI380_RS27455	COG2854	intermembrane phospholipid transfer
BI380_RS27465	COG1131	(ABC) transporter
BI380_RS27470	COG0842	Transport permease protein
BI380_RS27475	COG5007	Belongs to the BolA IbaG family
BI380_RS27480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BI380_RS27485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BI380_RS27490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BI380_RS27505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI380_RS27510	COG0131	Imidazoleglycerol-phosphate dehydratase
BI380_RS27520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BI380_RS27535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI380_RS27585	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BI380_RS27590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BI380_RS27595	COG1970	mechanosensitive ion channel activity
BI380_RS27600	COG0723	plastoquinol--plastocyanin reductase activity
BI380_RS27605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BI380_RS27610	COG2857	Cytochrome c1
BI380_RS27615	COG0625	glutathione transferase activity
BI380_RS27620	COG2969	positive regulation of protein catabolic process
BI380_RS27635	COG0653	protein targeting
BI380_RS27640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BI380_RS27650	COG0494	nUDIX hydrolase
BI380_RS27655	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BI380_RS27660	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BI380_RS27665	COG0237	dephospho-CoA kinase activity
BI380_RS27670	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BI380_RS27690	COG0142	geranyltranstransferase activity
BI380_RS27695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BI380_RS27700	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BI380_RS27705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BI380_RS27710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BI380_RS27715	COG0494	nUDIX hydrolase
BI380_RS27720	COG0442	prolyl-tRNA aminoacylation
BI380_RS27730	COG1253	flavin adenine dinucleotide binding
BI380_RS27735	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI380_RS27745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BI380_RS27750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BI380_RS27775	COG1511	domain protein
BI380_RS27775	COG3264	Mechanosensitive ion channel
BI380_RS27780	COG0584	glycerophosphoryl diester phosphodiesterase
BI380_RS27785	COG3842	ATPase activity
BI380_RS27790	COG0395	ABC-type sugar transport system, permease component
BI380_RS27800	COG1653	transport
BI380_RS27820	COG2226	methyltransferase
BI380_RS27835	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI380_RS27840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI380_RS27855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BI380_RS27875	COG0302	gtp cyclohydrolase
BI380_RS27905	COG0154	amidase activity
BI380_RS27910	COG0747	negative chemotaxis
BI380_RS27915	COG4608	Belongs to the ABC transporter superfamily
BI380_RS27920	COG0444	Belongs to the ABC transporter superfamily
BI380_RS27925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI380_RS27935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BI380_RS27940	COG0193	aminoacyl-tRNA hydrolase activity
BI380_RS27945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BI380_RS27950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BI380_RS27960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BI380_RS27965	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BI380_RS27970	COG0457	Tetratricopeptide repeat
BI380_RS27975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BI380_RS27995	COG4452	Inner membrane protein CreD
BI380_RS28000	COG2205	protein histidine kinase activity
BI380_RS28005	COG0745	RESPONSE REGULATOR receiver
BI380_RS28010	COG1660	Displays ATPase and GTPase activities
BI380_RS28015	COG0497	DNA recombination
BI380_RS28020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BI380_RS28070	COG1420	regulation of RNA biosynthetic process
BI380_RS28095	COG0745	RESPONSE REGULATOR receiver
BI380_RS28100	COG0180	Tryptophanyl-tRNA synthetase
BI380_RS28105	COG1994	Peptidase M50
BI380_RS28115	COG0009	L-threonylcarbamoyladenylate synthase
BI380_RS28120	COG0613	PHP domain protein
BI380_RS28125	COG0840	transmembrane signaling receptor activity
BI380_RS28145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BI380_RS28175	COG1136	(ABC) transporter
BI380_RS28185	COG0084	hydrolase, TatD family'
BI380_RS28200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI380_RS28220	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS28230	COG0697	spore germination
BI380_RS28245	COG1283	sodium-dependent phosphate transmembrane transporter activity
BI380_RS28250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BI380_RS28255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BI380_RS28260	COG0196	riboflavin kinase activity
BI380_RS28275	COG2205	protein histidine kinase activity
BI380_RS28280	COG2205	protein histidine kinase activity
BI380_RS28295	COG3781	membrane
BI380_RS28300	COG1960	acyl-CoA dehydrogenase activity
BI380_RS28305	COG1960	acyl-CoA dehydrogenase activity
BI380_RS28310	COG3132	Protein of unknown function, DUF480
BI380_RS28315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BI380_RS28325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BI380_RS28325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI380_RS28340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI380_RS28345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BI380_RS28350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BI380_RS28355	COG0492	ferredoxin-NADP+ reductase activity
BI380_RS28360	COG1674	ftsk spoiiie
BI380_RS28365	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BI380_RS28370	COG0840	transmembrane signaling receptor activity
BI380_RS28380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BI380_RS28390	COG4221	oxidoreductase activity
BI380_RS28405	COG0559	Belongs to the binding-protein-dependent transport system permease family
BI380_RS28430	COG1392	Phosphate transport regulator
BI380_RS28435	COG0306	phosphate transporter
BI380_RS28450	COG0228	four-way junction DNA binding
BI380_RS28455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BI380_RS28460	COG0336	Belongs to the RNA methyltransferase TrmD family
BI380_RS28465	COG0335	large ribosomal subunit rRNA binding
BI380_RS28470	COG0494	nUDIX hydrolase
BI380_RS28475	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI380_RS28480	COG1162	GTPase activity
BI380_RS28485	COG2154	pterin-4-alpha-carbinolamine dehydratase
BI380_RS28490	COG0501	Belongs to the peptidase M48B family
BI380_RS28495	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BI380_RS28500	COG0513	Belongs to the DEAD box helicase family
BI380_RS28505	COG5001	Diguanylate cyclase
BI380_RS28505	COG3300	MHYT domain
BI380_RS28510	COG2814	Major facilitator Superfamily
BI380_RS28515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI380_RS28535	COG0516	GMP reductase activity
BI380_RS28560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BI380_RS28575	COG0412	Dienelactone hydrolase
BI380_RS28595	COG0251	oxidation-reduction process
BI380_RS28610	COG3275	phosphorelay sensor kinase activity
BI380_RS28615	COG0165	Argininosuccinate lyase
BI380_RS28635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI380_RS28650	COG3842	ATPase activity
BI380_RS28665	COG0395	ABC-type sugar transport system, permease component
BI380_RS28695	COG1620	l-lactate permease
BI380_RS28700	COG1304	FMN binding
BI380_RS28705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI380_RS28720	COG1595	DNA-templated transcription, initiation
BI380_RS28735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI380_RS28740	COG0840	transmembrane signaling receptor activity
BI380_RS28745	COG4589	Belongs to the CDS family
BI380_RS28795	COG4964	Belongs to the GSP D family
BI380_RS28835	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI380_RS28835	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI380_RS28845	COG3022	response to hydroperoxide
BI380_RS28850	COG1530	ribonuclease E activity
BI380_RS28875	COG0616	signal peptide processing
BI380_RS28875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BI380_RS28880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BI380_RS28885	COG0424	maF-like protein
BI380_RS28890	COG1399	metal-binding, possibly nucleic acid-binding protein
BI380_RS28895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BI380_RS28900	COG0416	fatty acid biosynthetic process
BI380_RS28905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI380_RS28915	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS28920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI380_RS28925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BI380_RS28940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI380_RS28945	COG0481	GTPase activity
BI380_RS28950	COG0681	Belongs to the peptidase S26 family
BI380_RS28960	COG0571	ribonuclease III activity
BI380_RS28965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BI380_RS28970	COG1381	Involved in DNA repair and RecF pathway recombination
BI380_RS28975	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BI380_RS28980	COG0736	holo-[acyl-carrier-protein] synthase activity
BI380_RS28985	COG1472	Belongs to the glycosyl hydrolase 3 family
BI380_RS28995	COG3326	Membrane
BI380_RS29005	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BI380_RS29025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BI380_RS29035	COG0762	integral membrane protein
BI380_RS29045	COG0159	tryptophan synthase activity
BI380_RS29050	COG0133	tryptophan synthase activity
BI380_RS29055	COG0135	phosphoribosylanthranilate isomerase activity
BI380_RS29060	COG0101	tRNA pseudouridine synthase activity
BI380_RS29080	COG0473	3-isopropylmalate dehydrogenase activity
BI380_RS29085	COG0066	3-isopropylmalate dehydratase activity
BI380_RS29095	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BI380_RS29110	COG0484	heat shock protein binding
BI380_RS29115	COG0443	Heat shock 70 kDa protein
BI380_RS29120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BI380_RS29125	COG0360	Binds together with S18 to 16S ribosomal RNA
BI380_RS29135	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BI380_RS29140	COG0359	binds to the 23S rRNA
BI380_RS29155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BI380_RS29160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BI380_RS29170	COG0436	Aminotransferase
BI380_RS29180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BI380_RS29185	COG1763	Mo-molybdopterin cofactor biosynthetic process
BI380_RS29195	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BI380_RS29205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI380_RS29220	COG0314	molybdopterin synthase activity
BI380_RS29225	COG0697	spore germination
BI380_RS29235	COG0542	response to heat
BI380_RS29255	COG2264	protein methyltransferase activity
BI380_RS29270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI380_RS29275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI380_RS29275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI380_RS29300	COG4969	Belongs to the N-Me-Phe pilin family
BI380_RS29330	COG4970	Tfp pilus assembly protein FimT
BI380_RS29340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BI380_RS29345	COG1185	polyribonucleotide nucleotidyltransferase activity
BI380_RS29350	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS29350	COG3321	synthase
BI380_RS29350	COG0604	alcohol dehydrogenase
BI380_RS29355	COG0149	triose-phosphate isomerase activity
BI380_RS29370	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI380_RS29375	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI380_RS29380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI380_RS29385	COG0649	NAD binding
BI380_RS29400	COG1034	ATP synthesis coupled electron transport
BI380_RS29405	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BI380_RS29410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI380_RS29420	COG0713	ATP synthesis coupled electron transport
BI380_RS29435	COG1007	ATP synthesis coupled electron transport
BI380_RS29460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI380_RS29485	COG0463	Glycosyl transferase, family 2
BI380_RS29485	COG0457	Tetratricopeptide repeat
BI380_RS29510	COG1136	(ABC) transporter
BI380_RS29515	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BI380_RS29520	COG2814	Major facilitator Superfamily
BI380_RS29570	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BI380_RS29580	COG0657	acetylesterase activity
BI380_RS29585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI380_RS29600	COG0583	DNA-binding transcription factor activity
BI380_RS29605	COG1473	amidohydrolase
BI380_RS29615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BI380_RS29625	COG0586	Pfam SNARE associated Golgi protein
BI380_RS29635	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI380_RS29645	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI380_RS29665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI380_RS29685	COG4974	Belongs to the 'phage' integrase family
BI380_RS29690	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS29695	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BI380_RS29700	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BI380_RS29705	COG2833	Protein of unknown function (DUF455)
BI380_RS29715	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BI380_RS29725	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BI380_RS29730	COG0148	phosphopyruvate hydratase activity
BI380_RS29740	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BI380_RS29745	COG0504	CTP synthase activity
BI380_RS29750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BI380_RS29760	COG0756	dUTP diphosphatase activity
BI380_RS29795	COG1047	Peptidyl-prolyl cis-trans
BI380_RS29800	COG1012	belongs to the aldehyde dehydrogenase family
BI380_RS29810	COG2850	peptidyl-arginine hydroxylation
BI380_RS29820	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BI380_RS29825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI380_RS29845	COG1196	nuclear chromosome segregation
BI380_RS29845	COG0739	heme binding
BI380_RS29845	COG0741	lytic transglycosylase activity
BI380_RS29855	COG0840	transmembrane signaling receptor activity
BI380_RS29870	COG2308	Evidence 4 Homologs of previously reported genes of
BI380_RS29885	COG2271	Major facilitator Superfamily
BI380_RS29895	COG2205	protein histidine kinase activity
BI380_RS29915	COG4206	TonB-dependent receptor
BI380_RS29925	COG3720	iron ion transport
BI380_RS29940	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BI380_RS29955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI380_RS29995	COG1477	protein flavinylation
BI380_RS30000	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI380_RS30005	COG4771	TonB-dependent receptor
BI380_RS30010	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BI380_RS30015	COG1012	belongs to the aldehyde dehydrogenase family
BI380_RS30020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BI380_RS30035	COG2954	triphosphatase activity
BI380_RS30040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI380_RS30045	COG0358	DNA primase activity
BI380_RS30070	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS30080	COG0024	Methionine aminopeptidase
BI380_RS30090	COG1252	NADH dehydrogenase
BI380_RS30095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI380_RS30100	COG0786	glutamate:sodium symporter activity
BI380_RS30105	COG3540	Alkaline phosphatase
BI380_RS30110	COG3706	GGDEF domain
BI380_RS30115	COG0604	alcohol dehydrogenase
BI380_RS30115	COG3321	synthase
BI380_RS30115	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS30120	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BI380_RS30125	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI380_RS30135	COG0564	pseudouridine synthase activity
BI380_RS30140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BI380_RS30145	COG1187	pseudouridine synthase activity
BI380_RS30150	COG0105	UTP biosynthetic process
BI380_RS30155	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BI380_RS30170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BI380_RS30175	COG0124	histidyl-tRNA synthetase
BI380_RS30185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI380_RS30190	COG1160	GTP binding
BI380_RS30195	COG1923	regulation of RNA biosynthetic process
BI380_RS30200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BI380_RS30205	COG0330	HflC and HflK could
BI380_RS30210	COG0330	HflC and HflK could
BI380_RS30215	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BI380_RS30220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BI380_RS30225	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BI380_RS30250	COG1546	Belongs to the CinA family
BI380_RS30250	COG1058	Belongs to the CinA family
BI380_RS30255	COG0174	glutamine synthetase
BI380_RS30265	COG3852	Histidine kinase
BI380_RS30280	COG0708	Exodeoxyribonuclease III
BI380_RS30305	COG2948	multi-organism process
BI380_RS30310	COG3504	Conjugal transfer protein
BI380_RS30320	COG3846	protein secretion by the type IV secretion system
BI380_RS30335	COG3451	type IV secretory pathway VirB4
BI380_RS30350	COG4962	Type ii secretion system protein e
BI380_RS30370	COG0583	DNA-binding transcription factor activity
BI380_RS30375	COG2855	membrane
BI380_RS30380	COG0583	DNA-binding transcription factor activity
BI380_RS30400	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS30420	COG0778	Nitroreductase
BI380_RS30430	COG4372	Transposase
BI380_RS30455	COG1960	acyl-CoA dehydrogenase activity
BI380_RS30460	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI380_RS30460	COG1024	Enoyl-CoA hydratase
BI380_RS30465	COG0183	Belongs to the thiolase family
BI380_RS30490	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS30500	COG1960	acyl-CoA dehydrogenase activity
BI380_RS30505	COG1960	acyl-CoA dehydrogenase activity
BI380_RS30510	COG1960	acyl-CoA dehydrogenase activity
BI380_RS30520	COG2070	2-Nitropropane dioxygenase
BI380_RS30570	COG1396	sequence-specific DNA binding
BI380_RS30575	COG5489	Protein of unknown function (DUF736)
BI380_RS30580	COG3339	Conserved Protein
BI380_RS30600	COG1475	DNA binding
BI380_RS30625	COG2003	Belongs to the UPF0758 family
BI380_RS30645	COG0582	viral genome integration into host DNA
BI380_RS30655	COG0402	S-adenosylhomocysteine deaminase activity
BI380_RS30665	COG0583	DNA-binding transcription factor activity
BI380_RS30670	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS30720	COG4948	Mandelate Racemase Muconate Lactonizing
BI380_RS30745	COG4336	lyase activity
BI380_RS30755	COG2814	Major facilitator Superfamily
BI380_RS30765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI380_RS30770	COG1595	DNA-templated transcription, initiation
BI380_RS30785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BI380_RS30795	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BI380_RS30805	COG0277	FAD linked oxidase domain protein
BI380_RS30815	COG1295	ribonuclease BN
BI380_RS30850	COG1125	glycine betaine transport
BI380_RS30850	COG0517	IMP dehydrogenase activity
BI380_RS30860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BI380_RS30865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BI380_RS30870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BI380_RS30875	COG0741	lytic transglycosylase activity
BI380_RS30910	COG0557	exoribonuclease II activity
BI380_RS30915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BI380_RS30915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI380_RS30920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI380_RS30925	COG0052	Belongs to the universal ribosomal protein uS2 family
BI380_RS30930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BI380_RS30935	COG0528	UMP kinase activity
BI380_RS30940	COG0233	cytoplasmic translational termination
BI380_RS30950	COG0575	Belongs to the CDS family
BI380_RS30955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BI380_RS30975	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI380_RS30980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI380_RS30985	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI380_RS30990	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI380_RS30995	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BI380_RS31000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI380_RS31005	COG0505	Belongs to the CarA family
BI380_RS31010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BI380_RS31015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI380_RS31030	COG1534	Rna-binding protein
BI380_RS31035	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BI380_RS31040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BI380_RS31050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI380_RS31060	COG0248	Ppx GppA phosphatase
BI380_RS31070	COG0248	Ppx GppA phosphatase
BI380_RS31075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BI380_RS31080	COG0573	inorganic phosphate transmembrane transporter activity
BI380_RS31085	COG0581	inorganic phosphate transmembrane transporter activity
BI380_RS31090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BI380_RS31095	COG0704	Plays a role in the regulation of phosphate uptake
BI380_RS31110	COG0534	Mate efflux family protein
BI380_RS31120	COG0254	rRNA binding
BI380_RS31125	COG0372	Belongs to the citrate synthase family
BI380_RS31135	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BI380_RS31155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BI380_RS31160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BI380_RS31165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BI380_RS31180	COG1388	LysM domain
BI380_RS31180	COG0741	lytic transglycosylase activity
BI380_RS31185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI380_RS31190	COG2226	methyltransferase
BI380_RS31195	COG0328	RNA-DNA hybrid ribonuclease activity
BI380_RS31200	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BI380_RS31215	COG2175	clavaminate synthase activity
BI380_RS31220	COG3181	Tripartite tricarboxylate transporter family receptor
BI380_RS31235	COG0303	'Molybdopterin
BI380_RS31240	COG0746	molybdenum cofactor guanylyltransferase activity
BI380_RS31245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BI380_RS31260	COG1012	belongs to the aldehyde dehydrogenase family
BI380_RS31275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BI380_RS31285	COG0840	transmembrane signaling receptor activity
BI380_RS31300	COG0347	Belongs to the P(II) protein family
BI380_RS31310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BI380_RS31335	COG0028	Belongs to the TPP enzyme family
BI380_RS31340	COG0440	acetolactate synthase activity
BI380_RS31345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BI380_RS31350	COG1183	phosphatidylcholine synthase activity
BI380_RS31355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI380_RS31360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI380_RS31370	COG1414	Transcriptional regulator
BI380_RS31375	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BI380_RS31380	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BI380_RS31410	COG0242	peptide deformylase activity
BI380_RS31415	COG2233	PERMEase
BI380_RS31425	COG0024	Methionine aminopeptidase
BI380_RS31430	COG0047	phosphoribosylformylglycinamidine synthase activity
BI380_RS31430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BI380_RS31455	COG0714	Associated with various cellular activities
BI380_RS31460	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BI380_RS31465	COG3552	Protein containing von Willebrand factor type A (VWA) domain
BI380_RS31470	COG2354	Protein conserved in bacteria
BI380_RS31500	COG0625	glutathione transferase activity
BI380_RS31510	COG4774	siderophore transport
BI380_RS31520	COG1595	DNA-templated transcription, initiation
BI380_RS31525	COG3047	cAMP biosynthetic process
BI380_RS31530	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BI380_RS31535	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI380_RS31560	COG1024	Enoyl-CoA hydratase
BI380_RS31565	COG1028	Short-chain dehydrogenase reductase Sdr
BI380_RS31575	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS31580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI380_RS31585	COG0318	PFAM AMP-dependent synthetase and ligase
BI380_RS31595	COG1024	Enoyl-CoA hydratase
BI380_RS31620	COG0183	Belongs to the thiolase family
BI380_RS31635	COG0456	acetyltransferase
BI380_RS31640	COG0243	molybdopterin cofactor binding
BI380_RS31650	COG0826	peptidase U32
BI380_RS31675	COG3846	protein secretion by the type IV secretion system
BI380_RS31690	COG3451	type IV secretory pathway VirB4
BI380_RS31700	COG3838	Conjugal transfer protein Trbc
BI380_RS31705	COG4962	Type ii secretion system protein e
BI380_RS31735	COG2076	Multidrug Resistance protein
BI380_RS31740	COG0583	DNA-binding transcription factor activity
BI380_RS31770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI380_RS31775	COG1127	ABC transporter
BI380_RS31795	COG4959	Type IV secretory pathway protease TraF
BI380_RS31840	COG5489	Protein of unknown function (DUF736)
BI380_RS31850	COG1475	DNA binding
BI380_RS31865	COG2003	Belongs to the UPF0758 family
BI380_RS31870	COG4804	nuclease activity
BI380_RS31890	COG1619	proteins homologs of microcin C7 resistance protein MccF
BI380_RS31925	COG3842	ATPase activity
BI380_RS31935	COG1309	transcriptional regulator
BI380_RS31940	COG1113	amino acid transport
BI380_RS31950	COG0667	Aldo Keto reductase
BI380_RS31960	COG3655	Transcriptional regulator
BI380_RS31970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BI380_RS31975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BI380_RS31995	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BI380_RS32010	COG3577	Aspartyl protease
BI380_RS32015	COG1666	GTP binding
BI380_RS32020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BI380_RS32035	COG0583	DNA-binding transcription factor activity
BI380_RS32040	COG0137	argininosuccinate synthase activity
BI380_RS32045	COG3123	guanosine phosphorylase activity
BI380_RS32055	COG1393	Belongs to the ArsC family
BI380_RS32060	COG0285	dihydrofolate synthase activity
BI380_RS32085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI380_RS32150	COG0347	Belongs to the P(II) protein family
BI380_RS32210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI380_RS32220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI380_RS32225	COG4774	siderophore transport
BI380_RS32250	COG0657	acetylesterase activity
BI380_RS32270	COG1840	ABC-type Fe3 transport system, periplasmic component
BI380_RS32280	COG0824	Thioesterase
BI380_RS32285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BI380_RS32300	COG1322	Protein conserved in bacteria
BI380_RS32310	COG1611	Belongs to the LOG family
BI380_RS32320	COG2212	antiporter activity
BI380_RS32330	COG0651	ATP synthesis coupled electron transport
BI380_RS32335	COG1006	Multisubunit Na H antiporter MnhC subunit
BI380_RS32340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI380_RS32340	COG2111	Na H antiporter
BI380_RS32350	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BI380_RS32360	COG0776	regulation of translation
BI380_RS32370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BI380_RS32375	COG0287	Prephenate dehydrogenase
BI380_RS32380	COG0077	Prephenate dehydratase
BI380_RS32380	COG1605	Chorismate mutase
BI380_RS32385	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BI380_RS32400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BI380_RS32415	COG0582	viral genome integration into host DNA
BI380_RS32465	COG0270	DNA (cytosine-5-)-methyltransferase activity
BI380_RS32475	COG2916	Histone family protein nucleoid-structuring protein H-NS
BI380_RS32490	COG2974	May be involved in recombination
BI380_RS32555	COG1484	DNA-dependent DNA replication