locus-tag	class	description
DESME_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DESME_RS00015	COG0592	DNA-directed DNA polymerase activity
DESME_RS00030	COG0187	DNA topoisomerase II activity
DESME_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DESME_RS00040	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DESME_RS00045	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DESME_RS00070	COG0590	tRNA wobble adenosine to inosine editing
DESME_RS00080	COG0477	Major facilitator Superfamily
DESME_RS00095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DESME_RS00100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DESME_RS00115	COG0674	pyruvate-flavodoxin oxidoreductase activity
DESME_RS00115	COG1013	pyruvate-flavodoxin oxidoreductase activity
DESME_RS00115	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DESME_RS00115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DESME_RS00120	COG0697	spore germination
DESME_RS00135	COG1982	Orn Lys Arg decarboxylase major
DESME_RS00140	COG0470	DNA polymerase III
DESME_RS00145	COG1774	PSP1 C-terminal conserved region
DESME_RS00150	COG4467	Involved in initiation control of chromosome replication
DESME_RS00155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DESME_RS00160	COG2002	toxin-antitoxin pair type II binding
DESME_RS00165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DESME_RS00165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DESME_RS00170	COG0084	hydrolase, TatD family'
DESME_RS00175	COG3583	domain protein
DESME_RS00175	COG3584	3D domain protein
DESME_RS00180	COG3584	3D domain protein
DESME_RS00180	COG1388	LysM domain
DESME_RS00185	COG2247	cell wall binding repeat
DESME_RS00185	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESME_RS00195	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DESME_RS00210	COG0840	transmembrane signaling receptor activity
DESME_RS00235	COG1376	ErfK ybiS ycfS ynhG family protein
DESME_RS00240	COG4242	Belongs to the peptidase S51 family
DESME_RS00245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DESME_RS00245	COG0189	ligase activity
DESME_RS00255	COG1802	Transcriptional regulator
DESME_RS00260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DESME_RS00265	COG2088	sporulation resulting in formation of a cellular spore
DESME_RS00290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DESME_RS00295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DESME_RS00300	COG2002	toxin-antitoxin pair type II binding
DESME_RS00305	COG3956	TIGRFAM MazG family protein
DESME_RS00310	COG0776	regulation of translation
DESME_RS00315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DESME_RS00340	COG1098	S1 RNA binding domain
DESME_RS00365	COG3879	Bacterial protein of unknown function (DUF881)
DESME_RS00375	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DESME_RS00385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DESME_RS00390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DESME_RS00395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DESME_RS00415	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DESME_RS00415	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DESME_RS00420	COG1268	BioY protein
DESME_RS00430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DESME_RS00435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DESME_RS00440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DESME_RS00470	COG5278	phosphoserine phosphatase activity
DESME_RS00470	COG0840	transmembrane signaling receptor activity
DESME_RS00475	COG0398	Pfam SNARE associated Golgi protein
DESME_RS00490	COG0010	Belongs to the arginase family
DESME_RS00535	COG1484	DNA-dependent DNA replication
DESME_RS00540	COG4584	PFAM Integrase catalytic
DESME_RS00540	COG2390	Transcriptional regulator
DESME_RS00565	COG1982	Orn Lys Arg decarboxylase major
DESME_RS00570	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DESME_RS00580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DESME_RS00585	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DESME_RS00600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DESME_RS00610	COG0072	phenylalanine-tRNA ligase activity
DESME_RS00610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DESME_RS00625	COG0826	peptidase U32
DESME_RS00630	COG1193	negative regulation of DNA recombination
DESME_RS00635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DESME_RS00635	COG4499	WXG100 protein secretion system (Wss), protein YukC
DESME_RS00665	COG4134	Bacterial extracellular solute-binding protein
DESME_RS00670	COG4149	molybdate abc transporter
DESME_RS00675	COG1177	transmembrane transport
DESME_RS00680	COG3842	ATPase activity
DESME_RS00695	COG2271	Major facilitator Superfamily
DESME_RS00700	COG0437	4 iron, 4 sulfur cluster binding
DESME_RS00720	COG4948	Mandelate Racemase Muconate Lactonizing
DESME_RS00745	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DESME_RS00765	COG0544	peptidyl-prolyl cis-trans isomerase activity
DESME_RS00790	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DESME_RS00800	COG0303	'Molybdopterin
DESME_RS00805	COG1546	Belongs to the CinA family
DESME_RS00805	COG1058	Belongs to the CinA family
DESME_RS00810	COG1763	Mo-molybdopterin cofactor biosynthetic process
DESME_RS00815	COG0746	molybdenum cofactor guanylyltransferase activity
DESME_RS00830	COG0521	Mo-molybdopterin cofactor biosynthetic process
DESME_RS00835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DESME_RS00840	COG0583	DNA-binding transcription factor activity
DESME_RS00845	COG2814	Major facilitator Superfamily
DESME_RS00895	COG0697	spore germination
DESME_RS00955	COG0419	ATPase involved in DNA repair
DESME_RS00960	COG1196	nuclear chromosome segregation
DESME_RS01045	COG1484	DNA-dependent DNA replication
DESME_RS01050	COG2390	Transcriptional regulator
DESME_RS01050	COG4584	PFAM Integrase catalytic
DESME_RS01065	COG0628	permease
DESME_RS01070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DESME_RS01090	COG2414	aldehyde ferredoxin oxidoreductase
DESME_RS01105	COG1910	domain protein
DESME_RS01110	COG1454	alcohol dehydrogenase
DESME_RS01130	COG1910	domain protein
DESME_RS01135	COG0778	Nitroreductase
DESME_RS01135	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DESME_RS01150	COG2267	carboxylic ester hydrolase activity
DESME_RS01155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DESME_RS01165	COG2814	Major facilitator Superfamily
DESME_RS01170	COG1592	Rubrerythrin
DESME_RS01175	COG0840	transmembrane signaling receptor activity
DESME_RS01175	COG3290	protein histidine kinase activity
DESME_RS01180	COG0243	molybdopterin cofactor binding
DESME_RS01180	COG3383	formate dehydrogenase (NAD+) activity
DESME_RS01185	COG0243	molybdopterin cofactor binding
DESME_RS01185	COG3383	formate dehydrogenase (NAD+) activity
DESME_RS01190	COG0437	4 iron, 4 sulfur cluster binding
DESME_RS01215	COG4463	regulation of RNA biosynthetic process
DESME_RS01225	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DESME_RS01230	COG0542	response to heat
DESME_RS01235	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DESME_RS01240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DESME_RS01250	COG1329	Transcriptional regulator
DESME_RS01255	COG4956	integral membrane protein (PIN domain superfamily)
DESME_RS01260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DESME_RS01270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DESME_RS01275	COG1045	serine acetyltransferase
DESME_RS01285	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DESME_RS01295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DESME_RS01310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DESME_RS01315	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DESME_RS01320	COG0250	Participates in transcription elongation, termination and antitermination
DESME_RS01325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DESME_RS01335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DESME_RS01350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DESME_RS01355	COG1358	cellular component organization or biogenesis
DESME_RS01370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DESME_RS01385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DESME_RS01390	COG0088	Forms part of the polypeptide exit tunnel
DESME_RS01395	COG0089	rRNA binding
DESME_RS01405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DESME_RS01410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DESME_RS01415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DESME_RS01420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DESME_RS01425	COG0255	Belongs to the universal ribosomal protein uL29 family
DESME_RS01435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DESME_RS01440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DESME_RS01465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DESME_RS01480	COG0200	Binds to the 23S rRNA
DESME_RS01485	COG0201	protein transport
DESME_RS01500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DESME_RS01535	COG1122	ATPase activity
DESME_RS01540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DESME_RS01555	COG4585	Histidine kinase
DESME_RS01555	COG2203	Gaf domain
DESME_RS01595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DESME_RS01600	COG0101	tRNA pseudouridine synthase activity
DESME_RS01605	COG1342	Belongs to the UPF0251 family
DESME_RS01635	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESME_RS01650	COG1595	DNA-templated transcription, initiation
DESME_RS01660	COG1473	amidohydrolase
DESME_RS01670	COG2966	Psort location CytoplasmicMembrane, score
DESME_RS01675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DESME_RS01680	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DESME_RS01690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DESME_RS01700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DESME_RS01710	COG2323	membrane
DESME_RS01735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DESME_RS01750	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DESME_RS01755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DESME_RS01770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DESME_RS01775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DESME_RS01790	COG2181	nitrate reductase activity
DESME_RS01790	COG0247	lactate metabolic process
DESME_RS01795	COG1396	sequence-specific DNA binding
DESME_RS01845	COG1136	(ABC) transporter
DESME_RS01850	COG1136	(ABC) transporter
DESME_RS01850	COG0577	efflux transmembrane transporter activity
DESME_RS01860	COG2205	protein histidine kinase activity
DESME_RS01865	COG0745	RESPONSE REGULATOR receiver
DESME_RS01910	COG2210	Belongs to the sulfur carrier protein TusA family
DESME_RS01915	COG3052	prosthetic group binding
DESME_RS01935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DESME_RS01945	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DESME_RS01955	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DESME_RS01960	COG1132	(ABC) transporter
DESME_RS01965	COG1132	(ABC) transporter
DESME_RS01980	COG0701	Predicted permease
DESME_RS02105	COG1011	Hydrolase
DESME_RS02150	COG1683	Conserved Protein
DESME_RS02215	COG1408	metallophosphoesterase
DESME_RS02225	COG1162	GTPase activity
DESME_RS02240	COG0456	acetyltransferase
DESME_RS02240	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DESME_RS02250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DESME_RS02265	COG3852	Histidine kinase
DESME_RS02295	COG0438	transferase activity, transferring glycosyl groups
DESME_RS02300	COG2340	Cysteine-rich secretory protein family
DESME_RS02305	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DESME_RS02315	COG1694	Mazg nucleotide pyrophosphohydrolase
DESME_RS02320	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DESME_RS02330	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DESME_RS02335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DESME_RS02345	COG2390	Transcriptional regulator
DESME_RS02345	COG4584	PFAM Integrase catalytic
DESME_RS02350	COG1484	DNA-dependent DNA replication
DESME_RS02380	COG1104	cysteine desulfurase activity
DESME_RS02415	COG0789	Transcriptional regulator
DESME_RS02435	COG1595	DNA-templated transcription, initiation
DESME_RS02475	COG5001	Diguanylate cyclase
DESME_RS02475	COG3300	MHYT domain
DESME_RS02480	COG2226	methyltransferase
DESME_RS02485	COG3158	transport of potassium into the cell
DESME_RS02495	COG0765	amino acid transport
DESME_RS02500	COG1126	abc transporter atp-binding protein
DESME_RS02505	COG0662	Cupin 2, conserved barrel domain protein
DESME_RS02510	COG0726	polysaccharide deacetylase
DESME_RS02515	COG1595	DNA-templated transcription, initiation
DESME_RS02530	COG0586	Pfam SNARE associated Golgi protein
DESME_RS02535	COG0671	phosphoesterase, PA-phosphatase related
DESME_RS02545	COG0671	phosphoesterase, PA-phosphatase related
DESME_RS02550	COG3384	dioxygenase
DESME_RS02560	COG1966	Carbon starvation protein
DESME_RS02565	COG3546	catalase activity
DESME_RS02575	COG3852	Histidine kinase
DESME_RS02580	COG1827	regulation of RNA biosynthetic process
DESME_RS02585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DESME_RS02590	COG0157	Belongs to the NadC ModD family
DESME_RS02595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DESME_RS02600	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DESME_RS02615	COG1126	abc transporter atp-binding protein
DESME_RS02620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESME_RS02625	COG0765	amino acid transport
DESME_RS02630	COG0765	amino acid transport
DESME_RS02650	COG0004	ammonium transporteR
DESME_RS02655	COG0347	Belongs to the P(II) protein family
DESME_RS02660	COG0004	ammonium transporteR
DESME_RS02665	COG0347	Belongs to the P(II) protein family
DESME_RS02670	COG2508	Transcriptional regulator
DESME_RS02675	COG0842	Transport permease protein
DESME_RS02675	COG1129	ABC transporter
DESME_RS02695	COG1064	alcohol dehydrogenase
DESME_RS02700	COG0348	domain, Protein
DESME_RS02720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESME_RS02725	COG0745	RESPONSE REGULATOR receiver
DESME_RS02730	COG5002	protein histidine kinase activity
DESME_RS02740	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DESME_RS02745	COG0710	3-dehydroquinate dehydratase activity
DESME_RS02750	COG2259	Doxx family
DESME_RS02760	COG1595	DNA-templated transcription, initiation
DESME_RS02765	COG2259	Doxx family
DESME_RS02770	COG1733	regulation of RNA biosynthetic process
DESME_RS02780	COG3706	GGDEF domain
DESME_RS02825	COG4106	trans-aconitate 2-methyltransferase activity
DESME_RS02840	COG2755	lipolytic protein G-D-S-L family
DESME_RS02890	COG0189	ligase activity
DESME_RS02895	COG1509	lysine 2,3-aminomutase activity
DESME_RS02900	COG3344	reverse transcriptase
DESME_RS02920	COG1058	Belongs to the CinA family
DESME_RS02920	COG1546	Belongs to the CinA family
DESME_RS02925	COG0352	thiamine-phosphate diphosphorylase activity
DESME_RS02930	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DESME_RS02935	COG0351	phosphomethylpyrimidine kinase
DESME_RS02950	COG1028	Short-chain dehydrogenase reductase Sdr
DESME_RS02970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DESME_RS03005	COG2223	nitrite transmembrane transporter activity
DESME_RS03010	COG1695	Transcriptional regulator
DESME_RS03015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DESME_RS03030	COG3290	protein histidine kinase activity
DESME_RS03035	COG4565	transcriptional regulatory protein
DESME_RS03040	COG3493	citrate carrier protein
DESME_RS03045	COG0281	malic enzyme
DESME_RS03050	COG0385	Bile acid
DESME_RS03065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DESME_RS03080	COG0667	Aldo Keto reductase
DESME_RS03095	COG2610	gluconate transmembrane transporter activity
DESME_RS03100	COG1960	acyl-CoA dehydrogenase activity
DESME_RS03115	COG0644	oxidoreductase
DESME_RS03120	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DESME_RS03125	COG2030	dehydratase
DESME_RS03130	COG1024	Enoyl-CoA hydratase
DESME_RS03140	COG2030	dehydratase
DESME_RS03145	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DESME_RS03150	COG0644	oxidoreductase
DESME_RS03155	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DESME_RS03160	COG2086	electron transfer activity
DESME_RS03165	COG1960	acyl-CoA dehydrogenase activity
DESME_RS03170	COG2610	gluconate transmembrane transporter activity
DESME_RS03205	COG1950	PFAM Membrane protein of
DESME_RS03215	COG3585	molybdate ion transport
DESME_RS03225	COG4974	Belongs to the 'phage' integrase family
DESME_RS03230	COG0517	IMP dehydrogenase activity
DESME_RS03250	COG1408	metallophosphoesterase
DESME_RS03295	COG3547	Transposase (IS116 IS110 IS902 family)
DESME_RS03300	COG2155	Conserved Protein
DESME_RS03310	COG1605	Chorismate mutase
DESME_RS03310	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DESME_RS03320	COG0564	pseudouridine synthase activity
DESME_RS03335	COG0754	glutathionylspermidine amidase activity
DESME_RS03345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DESME_RS03350	COG1151	hydroxylamine reductase activity
DESME_RS03365	COG1993	acr, cog1993
DESME_RS03370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DESME_RS03380	COG0640	Transcriptional regulator
DESME_RS03385	COG2217	Heavy metal translocating P-type atpase
DESME_RS03390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DESME_RS03440	COG0419	ATPase involved in DNA repair
DESME_RS03450	COG1983	PspC domain protein
DESME_RS03460	COG1115	amino acid carrier protein
DESME_RS03465	COG0840	transmembrane signaling receptor activity
DESME_RS03475	COG0745	RESPONSE REGULATOR receiver
DESME_RS03480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DESME_RS03485	COG0573	inorganic phosphate transmembrane transporter activity
DESME_RS03490	COG0581	inorganic phosphate transmembrane transporter activity
DESME_RS03515	COG0640	Transcriptional regulator
DESME_RS03525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DESME_RS03535	COG0798	PFAM Bile acid sodium symporter
DESME_RS03540	COG4221	oxidoreductase activity
DESME_RS03545	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DESME_RS03585	COG2226	methyltransferase
DESME_RS03590	COG1410	methionine synthase
DESME_RS03590	COG0646	methionine synthase
DESME_RS03595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DESME_RS03595	COG0646	methionine synthase
DESME_RS03605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DESME_RS03615	COG0668	transmembrane transport
DESME_RS03625	COG1959	2 iron, 2 sulfur cluster binding
DESME_RS03650	COG0667	Aldo Keto reductase
DESME_RS03675	COG0789	Transcriptional regulator
DESME_RS03680	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DESME_RS03730	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DESME_RS03735	COG1797	cobyrinic acid a,c-diamide synthase activity
DESME_RS03740	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DESME_RS03750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DESME_RS03760	COG1271	oxidase subunit
DESME_RS03765	COG1294	oxidase, subunit
DESME_RS03770	COG4988	ABC transporter
DESME_RS03775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DESME_RS03805	COG2084	Dehydrogenase
DESME_RS03825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DESME_RS03830	COG1120	ATPase activity
DESME_RS03835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DESME_RS03860	COG3546	catalase activity
DESME_RS03865	COG1720	tRNA m6t6A37 methyltransferase activity
DESME_RS03870	COG1122	ATPase activity
DESME_RS03885	COG0346	lactoylglutathione lyase activity
DESME_RS03890	COG1242	4 iron, 4 sulfur cluster binding
DESME_RS03895	COG1509	lysine 2,3-aminomutase activity
DESME_RS03910	COG0736	holo-[acyl-carrier-protein] synthase activity
DESME_RS03915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DESME_RS03915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DESME_RS03925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DESME_RS03930	COG0569	domain protein
DESME_RS03935	COG0069	glutamate synthase activity
DESME_RS03935	COG0067	glutamate synthase
DESME_RS03935	COG0070	glutamate synthase
DESME_RS03940	COG0493	'glutamate synthase
DESME_RS03955	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DESME_RS03960	COG0840	transmembrane signaling receptor activity
DESME_RS03970	COG3442	glutamine amidotransferase
DESME_RS03975	COG0864	Transcriptional regulator
DESME_RS03980	COG2337	Toxic component of a toxin-antitoxin (TA) module
DESME_RS03985	COG0519	Catalyzes the synthesis of GMP from XMP
DESME_RS03985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DESME_RS03990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DESME_RS04005	COG1606	tRNA processing
DESME_RS04010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DESME_RS04015	COG0739	heme binding
DESME_RS04020	COG2183	response to ionizing radiation
DESME_RS04030	COG1228	amidohydrolase
DESME_RS04035	COG0802	atpase or kinase
DESME_RS04040	COG1214	PFAM Peptidase M22, glycoprotease
DESME_RS04045	COG0456	acetyltransferase
DESME_RS04050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DESME_RS04055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DESME_RS04075	COG3383	formate dehydrogenase (NAD+) activity
DESME_RS04080	COG1215	transferase activity, transferring glycosyl groups
DESME_RS04090	COG0746	molybdenum cofactor guanylyltransferase activity
DESME_RS04095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DESME_RS04110	COG0521	Mo-molybdopterin cofactor biosynthetic process
DESME_RS04130	COG0459	protein refolding
DESME_RS04150	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DESME_RS04155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DESME_RS04155	COG0519	Catalyzes the synthesis of GMP from XMP
DESME_RS04160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESME_RS04170	COG1131	(ABC) transporter
DESME_RS04180	COG3829	transcription factor binding
DESME_RS04180	COG3290	protein histidine kinase activity
DESME_RS04185	COG0659	secondary active sulfate transmembrane transporter activity
DESME_RS04195	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DESME_RS04200	COG0427	acetyl-CoA hydrolase
DESME_RS04220	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DESME_RS04240	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DESME_RS04240	COG2199	diguanylate cyclase activity
DESME_RS04245	COG0840	transmembrane signaling receptor activity
DESME_RS04255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DESME_RS04260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DESME_RS04265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DESME_RS04270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DESME_RS04280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DESME_RS04300	COG0840	transmembrane signaling receptor activity
DESME_RS04335	COG2011	ABC-type metal ion transport system permease component
DESME_RS04340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DESME_RS04345	COG4496	protein, YerC YecD
DESME_RS04365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DESME_RS04370	COG0131	Imidazoleglycerol-phosphate dehydratase
DESME_RS04380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DESME_RS04390	COG0140	phosphoribosyl-ATP diphosphatase activity
DESME_RS04390	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DESME_RS04395	COG0473	3-isopropylmalate dehydrogenase activity
DESME_RS04430	COG4566	intracellular signal transduction
DESME_RS04435	COG2172	sigma factor antagonist activity
DESME_RS04445	COG0840	transmembrane signaling receptor activity
DESME_RS04450	COG1966	Carbon starvation protein
DESME_RS04460	COG0210	DNA helicase
DESME_RS04480	COG0154	amidase activity
DESME_RS04485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DESME_RS04490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESME_RS04495	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DESME_RS04500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DESME_RS04510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DESME_RS04535	COG0375	protein maturation
DESME_RS04550	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DESME_RS04565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DESME_RS04570	COG1902	pentaerythritol trinitrate reductase activity
DESME_RS04570	COG0446	pyridine nucleotide-disulphide oxidoreductase
DESME_RS04575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESME_RS04590	COG3064	Membrane
DESME_RS04590	COG4991	sh3 domain protein
DESME_RS04590	COG0515	serine threonine protein kinase
DESME_RS04595	COG2244	polysaccharide biosynthetic process
DESME_RS04615	COG0789	Transcriptional regulator
DESME_RS04620	COG0655	NAD(P)H dehydrogenase (quinone) activity
DESME_RS04630	COG1979	alcohol dehydrogenase
DESME_RS04670	COG0697	spore germination
DESME_RS04680	COG1966	Carbon starvation protein
DESME_RS04695	COG1357	PFAM Pentapeptide repeats (8 copies)
DESME_RS04715	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DESME_RS04725	COG1028	Short-chain dehydrogenase reductase Sdr
DESME_RS04765	COG0538	isocitrate dehydrogenase activity
DESME_RS04805	COG1307	EDD domain protein, DegV family
DESME_RS04810	COG0436	Aminotransferase
DESME_RS04815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESME_RS04825	COG1971	Probably functions as a manganese efflux pump
DESME_RS04830	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DESME_RS04855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DESME_RS04860	COG0628	permease
DESME_RS04870	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DESME_RS04880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESME_RS04895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DESME_RS04900	COG4106	trans-aconitate 2-methyltransferase activity
DESME_RS04955	COG0310	cobalt ion transport
DESME_RS04965	COG1970	mechanosensitive ion channel activity
DESME_RS04970	COG1773	rubredoxin
DESME_RS04975	COG0803	Belongs to the bacterial solute-binding protein 9 family
DESME_RS04980	COG1121	(ABC) transporter
DESME_RS04985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DESME_RS04990	COG0735	belongs to the Fur family
DESME_RS05010	COG0564	pseudouridine synthase activity
DESME_RS05020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DESME_RS05025	COG1597	lipid kinase activity
DESME_RS05030	COG0617	tRNA 3'-terminal CCA addition
DESME_RS05035	COG1592	Rubrerythrin
DESME_RS05035	COG1773	rubredoxin
DESME_RS05040	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DESME_RS05050	COG5337	Spore coat protein CotH
DESME_RS05060	COG1484	DNA-dependent DNA replication
DESME_RS05065	COG4584	PFAM Integrase catalytic
DESME_RS05065	COG2390	Transcriptional regulator
DESME_RS05070	COG0436	Aminotransferase
DESME_RS05075	COG1522	sequence-specific DNA binding
DESME_RS05080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DESME_RS05085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DESME_RS05090	COG1388	LysM domain
DESME_RS05090	COG3858	chitin binding
DESME_RS05095	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DESME_RS05115	COG4109	DRTGG domain
DESME_RS05125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DESME_RS05155	COG1575	Belongs to the MenA family. Type 1 subfamily
DESME_RS05160	COG2081	HI0933 family
DESME_RS05165	COG0733	neurotransmitter:sodium symporter activity
DESME_RS05185	COG3290	protein histidine kinase activity
DESME_RS05185	COG0840	transmembrane signaling receptor activity
DESME_RS05190	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DESME_RS05200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DESME_RS05210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DESME_RS05210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DESME_RS05220	COG0488	(ABC) transporter
DESME_RS05225	COG1971	Probably functions as a manganese efflux pump
DESME_RS05230	COG0237	dephospho-CoA kinase activity
DESME_RS05235	COG0741	lytic transglycosylase activity
DESME_RS05260	COG2048	Heterodisulfide reductase, subunit B
DESME_RS05280	COG2048	Heterodisulfide reductase, subunit B
DESME_RS05295	COG3634	alkyl hydroperoxide reductase activity
DESME_RS05300	COG2226	methyltransferase
DESME_RS05330	COG0785	Cytochrome C biogenesis protein
DESME_RS05335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DESME_RS05340	COG2855	membrane
DESME_RS05345	COG0583	DNA-binding transcription factor activity
DESME_RS05365	COG0243	molybdopterin cofactor binding
DESME_RS05370	COG0437	4 iron, 4 sulfur cluster binding
DESME_RS05385	COG0348	domain, Protein
DESME_RS05395	COG0745	RESPONSE REGULATOR receiver
DESME_RS05400	COG5002	protein histidine kinase activity
DESME_RS05420	COG0310	cobalt ion transport
DESME_RS05445	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DESME_RS05445	COG3608	succinylglutamate desuccinylase aspartoacylase
DESME_RS05450	COG1687	branched-chain amino acid
DESME_RS05455	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DESME_RS05460	COG1522	sequence-specific DNA binding
DESME_RS05470	COG0460	homoserine dehydrogenase
DESME_RS05480	COG0028	Belongs to the TPP enzyme family
DESME_RS05485	COG0440	acetolactate synthase activity
DESME_RS05495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESME_RS05500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DESME_RS05505	COG0066	3-isopropylmalate dehydratase activity
DESME_RS05510	COG0473	3-isopropylmalate dehydrogenase activity
DESME_RS05515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DESME_RS05520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DESME_RS05525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DESME_RS05540	COG0243	molybdopterin cofactor binding
DESME_RS05550	COG0437	4 iron, 4 sulfur cluster binding
DESME_RS05555	COG3301	Polysulphide reductase, NrfD
DESME_RS05565	COG0723	plastoquinol--plastocyanin reductase activity
DESME_RS05585	COG0583	DNA-binding transcription factor activity
DESME_RS05590	COG2391	methyltransferase activity
DESME_RS05600	COG2391	methyltransferase activity
DESME_RS05625	COG0477	Major facilitator Superfamily
DESME_RS05630	COG1368	sulfuric ester hydrolase activity
DESME_RS05635	COG0740	serine-type endopeptidase activity
DESME_RS05640	COG1674	ftsk spoiiie
DESME_RS05645	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DESME_RS05650	COG1426	Protein conserved in bacteria
DESME_RS05670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESME_RS05675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DESME_RS05685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESME_RS05690	COG1546	Belongs to the CinA family
DESME_RS05690	COG1058	Belongs to the CinA family
DESME_RS05695	COG0513	Belongs to the DEAD box helicase family
DESME_RS05700	COG0861	Integral membrane protein TerC family
DESME_RS05705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DESME_RS05710	COG2137	regulation of response to DNA damage stimulus
DESME_RS05715	COG1418	mRNA catabolic process
DESME_RS05725	COG1692	metallophosphoesterase
DESME_RS05730	COG2359	stage V sporulation protein S
DESME_RS05740	COG0613	PHP domain protein
DESME_RS05745	COG0436	Aminotransferase
DESME_RS05760	COG0516	GMP reductase activity
DESME_RS05760	COG0517	IMP dehydrogenase activity
DESME_RS05770	COG1309	transcriptional regulator
DESME_RS05775	COG1968	undecaprenyl-diphosphatase activity
DESME_RS05835	COG0281	malic enzyme
DESME_RS05845	COG1139	Iron-sulfur cluster binding protein
DESME_RS05860	COG0251	oxidation-reduction process
DESME_RS05890	COG3858	chitin binding
DESME_RS05905	COG1918	ferrous iron import across plasma membrane
DESME_RS05905	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DESME_RS05915	COG2226	methyltransferase
DESME_RS05925	COG1739	Uncharacterized protein family UPF0029
DESME_RS05945	COG2720	vancomycin resistance protein
DESME_RS05970	COG1942	4-Oxalocrotonate Tautomerase
DESME_RS05985	COG0077	Prephenate dehydratase
DESME_RS05985	COG1605	Chorismate mutase
DESME_RS05995	COG1164	Oligoendopeptidase f
DESME_RS06005	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DESME_RS06020	COG1388	LysM domain
DESME_RS06020	COG0791	NLP P60 protein
DESME_RS06025	COG0322	excinuclease ABC activity
DESME_RS06045	COG0243	molybdopterin cofactor binding
DESME_RS06050	COG2814	Major facilitator Superfamily
DESME_RS06085	COG1199	ATP-dependent helicase activity
DESME_RS06085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DESME_RS06090	COG0688	phosphatidylethanolamine metabolic process
DESME_RS06110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DESME_RS06125	COG0745	RESPONSE REGULATOR receiver
DESME_RS06135	COG4166	transmembrane transport
DESME_RS06140	COG0601	transmembrane transport
DESME_RS06145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DESME_RS06150	COG0444	Belongs to the ABC transporter superfamily
DESME_RS06155	COG4608	Belongs to the ABC transporter superfamily
DESME_RS06170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DESME_RS06200	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DESME_RS06205	COG0174	glutamine synthetase
DESME_RS06215	COG2766	serine protein kinase
DESME_RS06220	COG2718	Belongs to the UPF0229 family
DESME_RS06225	COG2719	SpoVR family
DESME_RS06230	COG0586	Pfam SNARE associated Golgi protein
DESME_RS06240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DESME_RS06245	COG0583	DNA-binding transcription factor activity
DESME_RS06250	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DESME_RS06255	COG0205	6-phosphofructokinase activity
DESME_RS06270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DESME_RS06285	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DESME_RS06315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DESME_RS06320	COG0735	belongs to the Fur family
DESME_RS06330	COG0302	gtp cyclohydrolase
DESME_RS06350	COG2244	polysaccharide biosynthetic process
DESME_RS06355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DESME_RS06360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DESME_RS06365	COG2204	response regulator
DESME_RS06385	COG2823	Periplasmic or secreted lipoprotein
DESME_RS06395	COG1674	ftsk spoiiie
DESME_RS06415	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DESME_RS06425	COG1199	ATP-dependent helicase activity
DESME_RS06430	COG1850	ribulose-bisphosphate carboxylase activity
DESME_RS06435	COG0662	Cupin 2, conserved barrel domain protein
DESME_RS06445	COG1959	2 iron, 2 sulfur cluster binding
DESME_RS06455	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESME_RS06470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DESME_RS06485	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DESME_RS06490	COG2721	sulfolactate sulfo-lyase activity
DESME_RS06495	COG2721	sulfolactate sulfo-lyase activity
DESME_RS06505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DESME_RS06510	COG5002	protein histidine kinase activity
DESME_RS06515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DESME_RS06520	COG1388	LysM domain
DESME_RS06520	COG0791	NLP P60 protein
DESME_RS06530	COG0058	SHG alpha-glucan phosphorylase activity
DESME_RS06540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DESME_RS06545	COG0166	Belongs to the GPI family
DESME_RS06550	COG0837	glucose binding
DESME_RS06560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DESME_RS06565	COG1979	alcohol dehydrogenase
DESME_RS06580	COG1329	Transcriptional regulator
DESME_RS06595	COG0488	(ABC) transporter
DESME_RS06610	COG2814	Major facilitator Superfamily
DESME_RS06615	COG1030	water channel activity
DESME_RS06630	COG2996	Protein conserved in bacteria
DESME_RS06635	COG0446	pyridine nucleotide-disulphide oxidoreductase
DESME_RS06635	COG1902	pentaerythritol trinitrate reductase activity
DESME_RS06640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DESME_RS06650	COG0514	ATP-dependent DNA helicase (RecQ)
DESME_RS06680	COG3290	protein histidine kinase activity
DESME_RS06680	COG3829	transcription factor binding
DESME_RS06685	COG1250	3-hydroxyacyl-CoA dehydrogenase
DESME_RS06690	COG1960	acyl-CoA dehydrogenase activity
DESME_RS06695	COG2086	electron transfer activity
DESME_RS06700	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DESME_RS06705	COG0247	lactate metabolic process
DESME_RS06705	COG2181	nitrate reductase activity
DESME_RS06710	COG0183	Belongs to the thiolase family
DESME_RS06715	COG1024	Enoyl-CoA hydratase
DESME_RS06725	COG3344	reverse transcriptase
DESME_RS06730	COG3326	Membrane
DESME_RS06740	COG1408	metallophosphoesterase
DESME_RS06745	COG1132	(ABC) transporter
DESME_RS06750	COG1132	(ABC) transporter
DESME_RS06770	COG5577	PFAM Coat F domain
DESME_RS06775	COG2059	Chromate
DESME_RS06780	COG2059	Chromate
DESME_RS06785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DESME_RS06790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DESME_RS06795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DESME_RS06800	COG0390	transport system, permease component
DESME_RS06805	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DESME_RS06825	COG4120	Belongs to the binding-protein-dependent transport system permease family
DESME_RS06835	COG2823	Periplasmic or secreted lipoprotein
DESME_RS06835	COG1652	LysM domain
DESME_RS06840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DESME_RS06885	COG2197	response regulator
DESME_RS06910	COG1362	aminopeptidase activity
DESME_RS06920	COG1307	EDD domain protein, DegV family
DESME_RS06925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DESME_RS06930	COG0484	heat shock protein binding
DESME_RS06935	COG0542	response to heat
DESME_RS06970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DESME_RS06970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DESME_RS06980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DESME_RS06980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DESME_RS06995	COG1307	EDD domain protein, DegV family
DESME_RS07055	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DESME_RS07065	COG3935	DnaD domain protein
DESME_RS07105	COG1765	OsmC-like protein
DESME_RS07110	COG4632	Exopolysaccharide biosynthesis protein
DESME_RS07110	COG5434	Belongs to the glycosyl hydrolase 28 family
DESME_RS07120	COG1615	UPF0182 protein
DESME_RS07125	COG0492	ferredoxin-NADP+ reductase activity
DESME_RS07135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DESME_RS07140	COG0644	oxidoreductase
DESME_RS07150	COG0705	Rhomboid family
DESME_RS07150	COG0457	Tetratricopeptide repeat
DESME_RS07155	COG0768	penicillin binding
DESME_RS07160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DESME_RS07185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DESME_RS07190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DESME_RS07240	COG0824	Thioesterase
DESME_RS07250	COG1686	Belongs to the peptidase S11 family
DESME_RS07255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESME_RS07260	COG3679	Belongs to the UPF0342 family
DESME_RS07265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DESME_RS07275	COG0123	including yeast histone deacetylase and acetoin utilization protein
DESME_RS07280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DESME_RS07285	COG2521	methyltransferase
DESME_RS07285	COG2136	Putative SAM-dependent methyltransferase
DESME_RS07290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DESME_RS07300	COG1217	gtp-binding protein TYPA
DESME_RS07305	COG0464	growth
DESME_RS07310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DESME_RS07315	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DESME_RS07320	COG0681	Belongs to the peptidase S26 family
DESME_RS07325	COG1181	Belongs to the D-alanine--D-alanine ligase family
DESME_RS07340	COG1686	Belongs to the peptidase S11 family
DESME_RS07350	COG1484	DNA-dependent DNA replication
DESME_RS07355	COG4584	PFAM Integrase catalytic
DESME_RS07355	COG2390	Transcriptional regulator
DESME_RS07360	COG4974	Belongs to the 'phage' integrase family
DESME_RS07375	COG3118	belongs to the thioredoxin family
DESME_RS07410	COG1228	amidohydrolase
DESME_RS07435	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DESME_RS07440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DESME_RS07445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DESME_RS07450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DESME_RS07455	COG0569	domain protein
DESME_RS07460	COG0159	tryptophan synthase activity
DESME_RS07465	COG0133	tryptophan synthase activity
DESME_RS07490	COG1309	transcriptional regulator
DESME_RS07525	COG0840	transmembrane signaling receptor activity
DESME_RS07540	COG1139	Iron-sulfur cluster binding protein
DESME_RS07560	COG0559	Belongs to the binding-protein-dependent transport system permease family
DESME_RS07570	COG3875	lactate racemase activity
DESME_RS07590	COG0513	Belongs to the DEAD box helicase family
DESME_RS07605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESME_RS07640	COG1192	Involved in chromosome partitioning
DESME_RS07645	COG1061	Type III restriction enzyme res subunit
DESME_RS07675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DESME_RS07680	COG0436	Aminotransferase
DESME_RS07685	COG0371	Dehydrogenase
DESME_RS07695	COG2011	ABC-type metal ion transport system permease component
DESME_RS07700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DESME_RS07710	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DESME_RS07715	COG5002	protein histidine kinase activity
DESME_RS07745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DESME_RS07765	COG0674	pyruvate-flavodoxin oxidoreductase activity
DESME_RS07775	COG2873	o-acetylhomoserine
DESME_RS07790	COG3608	succinylglutamate desuccinylase aspartoacylase
DESME_RS07790	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DESME_RS07795	COG3608	succinylglutamate desuccinylase aspartoacylase
DESME_RS07795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DESME_RS07800	COG0719	Fe-S assembly protein
DESME_RS07810	COG2268	Band 7 protein
DESME_RS07835	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DESME_RS07840	COG1640	4-alpha-glucanotransferase
DESME_RS07850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DESME_RS07855	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DESME_RS07860	COG0058	SHG alpha-glucan phosphorylase activity
DESME_RS07865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DESME_RS07880	COG0204	Acyl-transferase
DESME_RS07890	COG0658	competence protein
DESME_RS07890	COG2333	competence protein COMEC
DESME_RS07915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DESME_RS07915	COG0551	DNA topoisomerase type I activity
DESME_RS07920	COG0385	Bile acid
DESME_RS07925	COG0517	IMP dehydrogenase activity
DESME_RS07945	COG1139	Iron-sulfur cluster binding protein
DESME_RS07955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DESME_RS07960	COG0372	Belongs to the citrate synthase family
DESME_RS07965	COG0582	viral genome integration into host DNA
DESME_RS07980	COG1671	Belongs to the UPF0178 family
DESME_RS07990	COG0488	(ABC) transporter
DESME_RS08010	COG2195	Cleaves the N-terminal amino acid of tripeptides
DESME_RS08025	COG1846	Transcriptional regulator
DESME_RS08035	COG0326	Molecular chaperone. Has ATPase activity
DESME_RS08075	COG0116	Belongs to the methyltransferase superfamily
DESME_RS08085	COG0527	aspartate kinase activity
DESME_RS08095	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DESME_RS08125	COG0697	spore germination
DESME_RS08145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DESME_RS08175	COG1794	racemase activity, acting on amino acids and derivatives
DESME_RS08185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DESME_RS08195	COG0456	acetyltransferase
DESME_RS08200	COG0791	NLP P60 protein
DESME_RS08200	COG1388	LysM domain
DESME_RS08200	COG3103	Sh3 type 3 domain protein
DESME_RS08205	COG1028	Short-chain dehydrogenase reductase Sdr
DESME_RS08215	COG2247	cell wall binding repeat
DESME_RS08215	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESME_RS08220	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DESME_RS08235	COG3344	reverse transcriptase
DESME_RS08250	COG0247	lactate metabolic process
DESME_RS08255	COG1139	Iron-sulfur cluster binding protein
DESME_RS08260	COG1556	Lactate utilization protein
DESME_RS08265	COG1533	DNA photolyase activity
DESME_RS08285	COG2323	membrane
DESME_RS08295	COG0367	asparagine synthase
DESME_RS08300	COG1253	flavin adenine dinucleotide binding
DESME_RS08315	COG1914	H( )-stimulated, divalent metal cation uptake system
DESME_RS08330	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DESME_RS08340	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DESME_RS08345	COG3706	GGDEF domain
DESME_RS08350	COG0398	Pfam SNARE associated Golgi protein
DESME_RS08360	COG1842	Phage shock protein A
DESME_RS08370	COG3256	nitric oxide reductase
DESME_RS08380	COG1929	Belongs to the glycerate kinase type-1 family
DESME_RS08385	COG0861	Integral membrane protein TerC family
DESME_RS08400	COG2720	vancomycin resistance protein
DESME_RS08405	COG1331	Highly conserved protein containing a thioredoxin domain
DESME_RS08420	COG0582	viral genome integration into host DNA
DESME_RS08460	COG4584	PFAM Integrase catalytic
DESME_RS08460	COG2390	Transcriptional regulator
DESME_RS08465	COG1484	DNA-dependent DNA replication
DESME_RS08560	COG0582	viral genome integration into host DNA
DESME_RS08670	COG0183	Belongs to the thiolase family
DESME_RS08675	COG1024	Enoyl-CoA hydratase
DESME_RS08680	COG1250	3-hydroxyacyl-CoA dehydrogenase
DESME_RS08685	COG1960	acyl-CoA dehydrogenase activity
DESME_RS08690	COG2814	Major facilitator Superfamily
DESME_RS08695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DESME_RS08700	COG3829	transcription factor binding
DESME_RS08700	COG3290	protein histidine kinase activity
DESME_RS08705	COG0437	4 iron, 4 sulfur cluster binding
DESME_RS08770	COG3005	denitrification pathway
DESME_RS08775	COG2197	response regulator
DESME_RS08790	COG1691	(AIR) carboxylase
DESME_RS08795	COG0517	IMP dehydrogenase activity
DESME_RS08795	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DESME_RS08805	COG2720	vancomycin resistance protein
DESME_RS08810	COG0142	geranyltranstransferase activity
DESME_RS08820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DESME_RS08840	COG1522	sequence-specific DNA binding
DESME_RS08845	COG0535	radical SAM domain protein
DESME_RS08850	COG0113	porphobilinogen synthase activity
DESME_RS08855	COG0535	radical SAM domain protein
DESME_RS08875	COG1648	precorrin-2 dehydrogenase activity
DESME_RS08875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DESME_RS08880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DESME_RS08885	COG1333	cytochrome c biogenesis protein
DESME_RS08890	COG3301	Polysulphide reductase, NrfD
DESME_RS08900	COG0142	geranyltranstransferase activity
DESME_RS08905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DESME_RS08910	COG0805	protein transport
DESME_RS08920	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DESME_RS08950	COG3655	Transcriptional regulator
DESME_RS08965	COG1668	transmembrane transport
DESME_RS08970	COG4152	abc transporter atp-binding protein
DESME_RS08980	COG1686	Belongs to the peptidase S11 family
DESME_RS08995	COG3339	Conserved Protein
DESME_RS09000	COG1388	LysM domain
DESME_RS09000	COG0791	NLP P60 protein
DESME_RS09010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DESME_RS09020	COG4656	Part of a membrane complex involved in electron transport
DESME_RS09025	COG4658	electron transport chain
DESME_RS09030	COG4659	FMN binding
DESME_RS09035	COG4660	Part of a membrane complex involved in electron transport
DESME_RS09040	COG4657	Part of a membrane complex involved in electron transport
DESME_RS09045	COG2878	Part of a membrane complex involved in electron transport
DESME_RS09045	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
DESME_RS09060	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DESME_RS09075	COG4974	Belongs to the 'phage' integrase family
DESME_RS09085	COG3158	transport of potassium into the cell
DESME_RS09100	COG3647	Membrane
DESME_RS09105	COG0577	efflux transmembrane transporter activity
DESME_RS09110	COG1136	(ABC) transporter
DESME_RS09115	COG5002	protein histidine kinase activity
DESME_RS09120	COG0745	RESPONSE REGULATOR receiver
DESME_RS09175	COG3344	reverse transcriptase
DESME_RS09205	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESME_RS09285	COG1484	DNA-dependent DNA replication
DESME_RS09305	COG4492	Belongs to the UPF0735 family
DESME_RS09310	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DESME_RS09315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DESME_RS09320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DESME_RS09345	COG0539	negative regulation of cytoplasmic translation
DESME_RS09345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DESME_RS09370	COG1620	l-lactate permease
DESME_RS09380	COG0287	Prephenate dehydrogenase
DESME_RS09385	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DESME_RS09390	COG4401	Chorismate mutase type I
DESME_RS09405	COG2081	HI0933 family
DESME_RS09415	COG0671	phosphoesterase, PA-phosphatase related
DESME_RS09425	COG2186	Transcriptional regulator
DESME_RS09430	COG2186	Transcriptional regulator
DESME_RS09450	COG1187	pseudouridine synthase activity
DESME_RS09465	COG0700	Nucleoside recognition
DESME_RS09470	COG2715	membrane protein required for spore maturation
DESME_RS09475	COG3874	Sporulation protein YtfJ
DESME_RS09490	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DESME_RS09500	COG1994	Peptidase M50
DESME_RS09505	COG3620	sequence-specific DNA binding
DESME_RS09505	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DESME_RS09505	COG0617	tRNA 3'-terminal CCA addition
DESME_RS09515	COG0598	Magnesium transport protein CorA
DESME_RS09520	COG1316	TRANSCRIPTIONal
DESME_RS09535	COG1924	4 iron, 4 sulfur cluster binding
DESME_RS09550	COG0697	spore germination
DESME_RS09560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DESME_RS09570	COG1366	Belongs to the anti-sigma-factor antagonist family
DESME_RS09575	COG2172	sigma factor antagonist activity
DESME_RS09580	COG1191	sigma factor activity
DESME_RS09585	COG1686	Belongs to the peptidase S11 family
DESME_RS09595	COG3275	phosphorelay sensor kinase activity
DESME_RS09600	COG0492	ferredoxin-NADP+ reductase activity
DESME_RS09605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESME_RS09610	COG0318	PFAM AMP-dependent synthetase and ligase
DESME_RS09615	COG0477	Major facilitator Superfamily
DESME_RS09625	COG0644	oxidoreductase
DESME_RS09630	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DESME_RS09635	COG2086	electron transfer activity
DESME_RS09650	COG1024	Enoyl-CoA hydratase
DESME_RS09660	COG1960	acyl-CoA dehydrogenase activity
DESME_RS09685	COG1960	acyl-CoA dehydrogenase activity
DESME_RS09720	COG1300	Membrane
DESME_RS09725	COG1379	DNA repair
DESME_RS09730	COG0494	nUDIX hydrolase
DESME_RS09750	COG0674	pyruvate-flavodoxin oxidoreductase activity
DESME_RS09750	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DESME_RS09760	COG3829	transcription factor binding
DESME_RS09760	COG3290	protein histidine kinase activity
DESME_RS09785	COG0745	RESPONSE REGULATOR receiver
DESME_RS09790	COG0750	zinc metalloprotease
DESME_RS09795	COG0497	DNA recombination
DESME_RS09805	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DESME_RS09810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DESME_RS09815	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DESME_RS09820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DESME_RS09840	COG1722	exodeoxyribonuclease VII activity
DESME_RS09845	COG1570	exodeoxyribonuclease VII activity
DESME_RS09860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DESME_RS09865	COG0288	reversible hydration of carbon dioxide
DESME_RS09870	COG2020	methyltransferase activity
DESME_RS09910	COG2264	protein methyltransferase activity
DESME_RS09920	COG2226	methyltransferase
DESME_RS09945	COG0493	'glutamate synthase
DESME_RS09950	COG0543	2 iron, 2 sulfur cluster binding
DESME_RS09955	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DESME_RS09975	COG1302	Protein conserved in bacteria
DESME_RS09980	COG0439	Biotin carboxylase
DESME_RS09985	COG5016	pyruvate
DESME_RS09985	COG0511	ligase activity, forming carbon-carbon bonds
DESME_RS09990	COG2201	protein-glutamate methylesterase activity
DESME_RS10030	COG3854	ATPases associated with a variety of cellular activities
DESME_RS10035	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DESME_RS10040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DESME_RS10045	COG0006	proline dipeptidase activity
DESME_RS10065	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DESME_RS10070	COG2165	general secretion pathway protein
DESME_RS10085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DESME_RS10105	COG2165	general secretion pathway protein
DESME_RS10110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DESME_RS10115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DESME_RS10130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DESME_RS10135	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DESME_RS10185	COG4968	Prepilin-type N-terminal cleavage methylation domain
DESME_RS10190	COG1459	type II secretion system
DESME_RS10195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DESME_RS10210	COG0826	peptidase U32
DESME_RS10215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DESME_RS10220	COG2720	vancomycin resistance protein
DESME_RS10225	COG3906	Belongs to the UPF0473 family
DESME_RS10240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DESME_RS10245	COG0628	permease
DESME_RS10260	COG0482	sulfurtransferase activity
DESME_RS10265	COG0822	iron-sulfur transferase activity
DESME_RS10275	COG1959	2 iron, 2 sulfur cluster binding
DESME_RS10280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DESME_RS10285	COG3118	belongs to the thioredoxin family
DESME_RS10290	COG1937	Protein conserved in bacteria
DESME_RS10295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DESME_RS10310	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DESME_RS10315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DESME_RS10320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESME_RS10330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DESME_RS10340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DESME_RS10340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DESME_RS10355	COG0440	acetolactate synthase activity
DESME_RS10360	COG0028	Belongs to the TPP enzyme family
DESME_RS10365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DESME_RS10370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DESME_RS10385	COG1862	Preprotein translocase
DESME_RS10400	COG2385	sporulation resulting in formation of a cellular spore
DESME_RS10410	COG0632	four-way junction helicase activity
DESME_RS10435	COG0318	PFAM AMP-dependent synthetase and ligase
DESME_RS10450	COG0488	(ABC) transporter
DESME_RS10455	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
DESME_RS10460	COG0730	response to heat
DESME_RS10660	COG2364	Membrane
DESME_RS10680	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DESME_RS10690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DESME_RS10695	COG0527	aspartate kinase activity
DESME_RS10700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DESME_RS10705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DESME_RS10710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DESME_RS10720	COG1873	PFAM PRC-barrel domain
DESME_RS10735	COG0612	Peptidase, M16
DESME_RS10740	COG1686	Belongs to the peptidase S11 family
DESME_RS10755	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DESME_RS10760	COG0196	riboflavin kinase activity
DESME_RS10765	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DESME_RS10770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DESME_RS10780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DESME_RS10790	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DESME_RS10795	COG0195	Participates in both transcription termination and antitermination
DESME_RS10800	COG0779	Required for maturation of 30S ribosomal subunits
DESME_RS10810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DESME_RS10815	COG0750	zinc metalloprotease
DESME_RS10825	COG0628	permease
DESME_RS10845	COG0528	UMP kinase activity
DESME_RS10880	COG4974	Belongs to the 'phage' integrase family
DESME_RS10885	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DESME_RS10890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DESME_RS10895	COG0758	DNA mediated transformation
DESME_RS10895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DESME_RS10905	COG1793	dna ligase
DESME_RS10920	COG0071	Belongs to the small heat shock protein (HSP20) family
DESME_RS10925	COG2217	Heavy metal translocating P-type atpase
DESME_RS10925	COG2608	mercury ion transmembrane transporter activity
DESME_RS10930	COG2217	Heavy metal translocating P-type atpase
DESME_RS10940	COG1250	3-hydroxyacyl-CoA dehydrogenase
DESME_RS10945	COG0183	Belongs to the thiolase family
DESME_RS10950	COG1960	acyl-CoA dehydrogenase activity
DESME_RS10955	COG0427	acetyl-CoA hydrolase
DESME_RS10970	COG5002	protein histidine kinase activity
DESME_RS10975	COG0745	RESPONSE REGULATOR receiver
DESME_RS10980	COG0792	nuclease activity
DESME_RS10990	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESME_RS10995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DESME_RS11010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESME_RS11015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DESME_RS11020	COG0649	NAD binding
DESME_RS11025	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESME_RS11035	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESME_RS11045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DESME_RS11060	COG4752	Belongs to the RNA methyltransferase TrmD family
DESME_RS11065	COG0336	Belongs to the RNA methyltransferase TrmD family
DESME_RS11070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DESME_RS11075	COG1837	Belongs to the UPF0109 family
DESME_RS11085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DESME_RS11095	COG0456	acetyltransferase
DESME_RS11105	COG1136	(ABC) transporter
DESME_RS11115	COG0745	RESPONSE REGULATOR receiver
DESME_RS11120	COG3850	Histidine kinase
DESME_RS11120	COG5002	protein histidine kinase activity
DESME_RS11125	COG0488	(ABC) transporter
DESME_RS11130	COG1215	transferase activity, transferring glycosyl groups
DESME_RS11135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DESME_RS11145	COG2080	2 iron, 2 sulfur cluster binding
DESME_RS11150	COG1388	LysM domain
DESME_RS11175	COG0517	IMP dehydrogenase activity
DESME_RS11180	COG4974	Belongs to the 'phage' integrase family
DESME_RS11185	COG1484	DNA-dependent DNA replication
DESME_RS11190	COG2390	Transcriptional regulator
DESME_RS11190	COG4584	PFAM Integrase catalytic
DESME_RS11220	COG4895	conserved protein (DUF2196)
DESME_RS11225	COG0402	S-adenosylhomocysteine deaminase activity
DESME_RS11235	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DESME_RS11240	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DESME_RS11245	COG0552	protein localization to endoplasmic reticulum
DESME_RS11250	COG1196	nuclear chromosome segregation
DESME_RS11255	COG0571	ribonuclease III activity
DESME_RS11260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DESME_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
DESME_RS11280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DESME_RS11300	COG2030	dehydratase
DESME_RS11310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DESME_RS11315	COG1752	Esterase of the alpha-beta hydrolase superfamily
DESME_RS11320	COG3314	Sporulation integral membrane protein YlbJ
DESME_RS11330	COG0742	ribosomal rna small subunit methyltransferase
DESME_RS11345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DESME_RS11350	COG1760	l-serine dehydratase
DESME_RS11355	COG1760	l-serine dehydratase
DESME_RS11360	COG1461	Dihydroxyacetone kinase
DESME_RS11365	COG1302	Protein conserved in bacteria
DESME_RS11375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DESME_RS11380	COG1564	THIamine pyrophosphokinase
DESME_RS11385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DESME_RS11390	COG1162	GTPase activity
DESME_RS11395	COG2815	serine threonine protein kinase
DESME_RS11395	COG0515	serine threonine protein kinase
DESME_RS11400	COG0768	penicillin binding
DESME_RS11410	COG0631	protein serine/threonine phosphatase activity
DESME_RS11415	COG1716	ATPase activity
DESME_RS11430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DESME_RS11430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DESME_RS11435	COG2738	Putative neutral zinc metallopeptidase
DESME_RS11440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DESME_RS11445	COG0242	peptide deformylase activity
DESME_RS11450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DESME_RS11465	COG0534	Mate efflux family protein
DESME_RS11470	COG1846	Transcriptional regulator
DESME_RS11475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DESME_RS11480	COG4149	molybdate abc transporter
DESME_RS11485	COG0725	ABC transporter, periplasmic molybdate-binding protein
DESME_RS11490	COG1910	domain protein
DESME_RS11500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DESME_RS11510	COG0194	GDP metabolic process
DESME_RS11520	COG1561	YicC-like family, N-terminal region
DESME_RS11530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DESME_RS11540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DESME_RS11555	COG0438	transferase activity, transferring glycosyl groups
DESME_RS11565	COG1215	transferase activity, transferring glycosyl groups
DESME_RS11570	COG4464	protein tyrosine phosphatase activity
DESME_RS11575	COG0489	protein tyrosine kinase activity
DESME_RS11580	COG3944	biosynthesis protein
DESME_RS11590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DESME_RS11595	COG0284	orotidine-5'-phosphate decarboxylase activity
DESME_RS11600	COG0167	dihydroorotate dehydrogenase activity
DESME_RS11605	COG0543	2 iron, 2 sulfur cluster binding
DESME_RS11610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DESME_RS11615	COG0505	Belongs to the CarA family
DESME_RS11620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DESME_RS11630	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DESME_RS11635	COG0564	pseudouridine synthase activity
DESME_RS11660	COG1924	4 iron, 4 sulfur cluster binding
DESME_RS11665	COG1309	transcriptional regulator
DESME_RS11670	COG0280	phosphate acetyltransferase
DESME_RS11680	COG2045	Belongs to the ComB family
DESME_RS11685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DESME_RS11690	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DESME_RS11695	COG0509	glycine decarboxylation via glycine cleavage system
DESME_RS11705	COG0840	transmembrane signaling receptor activity
DESME_RS11720	COG3599	regulation of cell shape
DESME_RS11725	COG2302	S4 RNA-binding domain
DESME_RS11735	COG1799	cell septum assembly
DESME_RS11740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DESME_RS11750	COG5002	protein histidine kinase activity
DESME_RS11755	COG0745	RESPONSE REGULATOR receiver
DESME_RS11760	COG1496	oxidoreductase activity
DESME_RS11765	COG1873	PFAM PRC-barrel domain
DESME_RS11770	COG1191	sigma factor activity
DESME_RS11775	COG1191	sigma factor activity
DESME_RS11785	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DESME_RS11790	COG3856	small basic protein
DESME_RS11795	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DESME_RS11800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DESME_RS11805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DESME_RS11820	COG0772	Belongs to the SEDS family
DESME_RS11835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DESME_RS11845	COG0768	penicillin binding
DESME_RS11860	COG2001	Belongs to the MraZ family
DESME_RS11865	COG2204	response regulator
DESME_RS11900	COG2252	PERMEase
DESME_RS11905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DESME_RS11925	COG0735	belongs to the Fur family
DESME_RS11930	COG2221	Nitrite and sulphite reductase 4Fe-4S
DESME_RS11940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DESME_RS11950	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DESME_RS11975	COG1283	sodium-dependent phosphate transmembrane transporter activity
DESME_RS11985	COG0303	'Molybdopterin
DESME_RS11995	COG1316	TRANSCRIPTIONal
DESME_RS12000	COG0709	Synthesizes selenophosphate from selenide and ATP
DESME_RS12005	COG1921	L-seryl-tRNASec selenium transferase activity
DESME_RS12015	COG4862	establishment of competence for transformation
DESME_RS12035	COG3706	GGDEF domain
DESME_RS12040	COG0741	lytic transglycosylase activity
DESME_RS12045	COG0835	chemotaxis
DESME_RS12050	COG4786	Flagellar basal body rod
DESME_RS12060	COG4786	Flagellar basal body rod
DESME_RS12070	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DESME_RS12080	COG1191	sigma factor activity
DESME_RS12095	COG1776	CheC inhibitor of MCP methylation
DESME_RS12110	COG1419	protein localization to endoplasmic reticulum
DESME_RS12115	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DESME_RS12120	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DESME_RS12125	COG1684	flagellar biosynthetic protein fliR
DESME_RS12130	COG1987	bacterial-type flagellum assembly
DESME_RS12135	COG1338	Plays a role in the flagellum-specific transport system
DESME_RS12145	COG2201	protein-glutamate methylesterase activity
DESME_RS12150	COG1776	CheC inhibitor of MCP methylation
DESME_RS12150	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DESME_RS12155	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DESME_RS12175	COG1157	protein secretion by the type III secretion system
DESME_RS12185	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DESME_RS12190	COG1766	The M ring may be actively involved in energy transduction
DESME_RS12200	COG1558	bacterial-type flagellum-dependent cell motility
DESME_RS12205	COG2201	protein-glutamate methylesterase activity
DESME_RS12215	COG0835	chemotaxis
DESME_RS12220	COG0643	Histidine kinase
DESME_RS12220	COG2198	Histidine kinase
DESME_RS12235	COG1516	flagellar protein fliS
DESME_RS12240	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DESME_RS12250	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DESME_RS12255	COG2089	acid synthase
DESME_RS12260	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DESME_RS12260	COG0517	IMP dehydrogenase activity
DESME_RS12265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DESME_RS12270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DESME_RS12290	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DESME_RS12305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DESME_RS12310	COG1256	bacterial-type flagellum assembly
DESME_RS12310	COG4786	Flagellar basal body rod
DESME_RS12330	COG1360	Flagellar Motor Protein
DESME_RS12340	COG1728	Protein conserved in bacteria
DESME_RS12345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DESME_RS12360	COG2076	Multidrug Resistance protein
DESME_RS12370	COG0723	plastoquinol--plastocyanin reductase activity
DESME_RS12370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DESME_RS12380	COG2814	Major facilitator Superfamily
DESME_RS12390	COG2384	SAM-dependent methyltransferase
DESME_RS12420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DESME_RS12425	COG0358	DNA primase activity
DESME_RS12435	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DESME_RS12445	COG0840	transmembrane signaling receptor activity
DESME_RS12450	COG0640	Transcriptional regulator
DESME_RS12460	COG3973	AAA domain
DESME_RS12470	COG3682	Transcriptional regulator
DESME_RS12475	COG0574	Belongs to the PEP-utilizing enzyme family
DESME_RS12475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DESME_RS12485	COG0517	IMP dehydrogenase activity
DESME_RS12490	COG4632	Exopolysaccharide biosynthesis protein
DESME_RS12490	COG5434	Belongs to the glycosyl hydrolase 28 family
DESME_RS12495	COG0751	glycine-tRNA ligase activity
DESME_RS12510	COG1381	Involved in DNA repair and RecF pathway recombination
DESME_RS12520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DESME_RS12525	COG0295	cytidine deaminase activity
DESME_RS12530	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DESME_RS12540	COG1480	7TM receptor with intracellular HD hydrolase
DESME_RS12545	COG1702	phosphate starvation-inducible protein PhoH
DESME_RS12560	COG1285	pathogenesis
DESME_RS12565	COG0672	)-iron permease
DESME_RS12570	COG3260	NADH ubiquinone oxidoreductase 20
DESME_RS12575	COG3261	NADH dehydrogenase
DESME_RS12575	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
DESME_RS12580	COG0651	ATP synthesis coupled electron transport
DESME_RS12590	COG0650	Formate hydrogenlyase subunit 4
DESME_RS12595	COG0651	ATP synthesis coupled electron transport
DESME_RS12605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DESME_RS12610	COG1610	YqeY-like protein
DESME_RS12620	COG0537	adenosine 5'-monophosphoramidase activity
DESME_RS12625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESME_RS12630	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DESME_RS12635	COG2264	protein methyltransferase activity
DESME_RS12660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DESME_RS12700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESME_RS12720	COG0799	negative regulation of ribosome biogenesis
DESME_RS12725	COG1713	HD superfamily hydrolase involved in NAD metabolism
DESME_RS12725	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DESME_RS12730	COG0724	RNA recognition motif
DESME_RS12765	COG4473	ABC transporter
DESME_RS12770	COG1131	(ABC) transporter
DESME_RS12795	COG2814	Major facilitator Superfamily
DESME_RS12810	COG0577	efflux transmembrane transporter activity
DESME_RS12835	COG2868	ribosomal protein
DESME_RS12845	COG2050	protein possibly involved in aromatic compounds catabolism
DESME_RS12850	COG4948	Mandelate Racemase Muconate Lactonizing
DESME_RS12855	COG0318	PFAM AMP-dependent synthetase and ligase
DESME_RS12860	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DESME_RS12865	COG0596	Alpha beta hydrolase
DESME_RS12875	COG1169	isochorismate synthase
DESME_RS12885	COG1530	ribonuclease E activity
DESME_RS12900	COG1994	Peptidase M50
DESME_RS12910	COG0772	Belongs to the SEDS family
DESME_RS12920	COG2894	cell division
DESME_RS12925	COG0850	regulation of cytokinetic process
DESME_RS12930	COG0768	penicillin binding
DESME_RS12945	COG1077	Cell shape determining protein MreB Mrl
DESME_RS12955	COG0424	maF-like protein
DESME_RS12965	COG0531	amino acid
DESME_RS12985	COG0306	phosphate transporter
DESME_RS12995	COG0285	dihydrofolate synthase activity
DESME_RS13000	COG0525	valine-tRNA ligase activity
DESME_RS13005	COG0840	transmembrane signaling receptor activity
DESME_RS13010	COG0069	glutamate synthase activity
DESME_RS13020	COG1388	LysM domain
DESME_RS13050	COG3706	GGDEF domain
DESME_RS13060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DESME_RS13065	COG1067	ATP-dependent peptidase activity
DESME_RS13065	COG0470	DNA polymerase III
DESME_RS13070	COG0134	indole-3-glycerol-phosphate synthase activity
DESME_RS13075	COG0135	phosphoribosylanthranilate isomerase activity
DESME_RS13080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DESME_RS13085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DESME_RS13090	COG0512	Glutamine amidotransferase of anthranilate synthase
DESME_RS13100	COG0544	peptidyl-prolyl cis-trans isomerase activity
DESME_RS13105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DESME_RS13145	COG1620	l-lactate permease
DESME_RS13150	COG0277	FAD linked oxidase domain protein
DESME_RS13155	COG0277	FAD linked oxidase domain protein
DESME_RS13160	COG0247	lactate metabolic process
DESME_RS13165	COG1414	Transcriptional regulator
DESME_RS13185	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DESME_RS13190	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DESME_RS13200	COG4122	O-methyltransferase activity
DESME_RS13205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DESME_RS13205	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DESME_RS13210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DESME_RS13215	COG0840	transmembrane signaling receptor activity
DESME_RS13240	COG3799	methylaspartate ammonia-lyase activity
DESME_RS13250	COG4865	methylaspartate mutase activity
DESME_RS13260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DESME_RS13265	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DESME_RS13270	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESME_RS13270	COG2247	cell wall binding repeat
DESME_RS13275	COG1136	(ABC) transporter
DESME_RS13275	COG0577	efflux transmembrane transporter activity
DESME_RS13280	COG1136	(ABC) transporter
DESME_RS13290	COG2205	protein histidine kinase activity
DESME_RS13295	COG0745	RESPONSE REGULATOR receiver
DESME_RS13300	COG1846	Transcriptional regulator
DESME_RS13355	COG1408	metallophosphoesterase
DESME_RS13360	COG0427	acetyl-CoA hydrolase
DESME_RS13365	COG0183	Belongs to the thiolase family
DESME_RS13380	COG0793	Belongs to the peptidase S41A family
DESME_RS13380	COG3409	Peptidoglycan-binding domain 1 protein
DESME_RS13390	COG1194	a g-specific adenine glycosylase
DESME_RS13405	COG2848	UPF0210 protein
DESME_RS13410	COG3830	Belongs to the UPF0237 family
DESME_RS13415	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESME_RS13415	COG2247	cell wall binding repeat
DESME_RS13420	COG0513	Belongs to the DEAD box helicase family
DESME_RS13440	COG3875	lactate racemase activity
DESME_RS13490	COG1122	ATPase activity
DESME_RS13495	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DESME_RS13505	COG1528	Iron-storage protein
DESME_RS13520	COG4608	Belongs to the ABC transporter superfamily
DESME_RS13525	COG0444	Belongs to the ABC transporter superfamily
DESME_RS13530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DESME_RS13535	COG0601	transmembrane transport
DESME_RS13540	COG0747	negative chemotaxis
DESME_RS13545	COG3706	GGDEF domain
DESME_RS13545	COG4251	negative regulation of phosphorylation
DESME_RS13545	COG2203	Gaf domain
DESME_RS13545	COG5001	Diguanylate cyclase
DESME_RS13595	COG2247	cell wall binding repeat
DESME_RS13595	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESME_RS13635	COG1131	(ABC) transporter
DESME_RS13660	COG0166	Belongs to the GPI family
DESME_RS13670	COG2076	Multidrug Resistance protein
DESME_RS13675	COG0463	Glycosyl transferase, family 2
DESME_RS13710	COG0730	response to heat
DESME_RS13715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DESME_RS13730	COG1959	2 iron, 2 sulfur cluster binding
DESME_RS13735	COG1091	dTDP-4-dehydrorhamnose reductase activity
DESME_RS13745	COG0175	sulfate reduction
DESME_RS13780	COG1088	dTDP-glucose 4,6-dehydratase activity
DESME_RS13805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DESME_RS13820	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESME_RS13820	COG2247	cell wall binding repeat
DESME_RS13825	COG1404	Belongs to the peptidase S8 family
DESME_RS13830	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESME_RS13830	COG2247	cell wall binding repeat
DESME_RS13840	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DESME_RS13845	COG1696	Membrane protein involved in D-alanine export
DESME_RS13855	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DESME_RS13870	COG0297	glycogen (starch) synthase activity
DESME_RS13905	COG0438	transferase activity, transferring glycosyl groups
DESME_RS13925	COG0673	inositol 2-dehydrogenase activity
DESME_RS13930	COG1086	Polysaccharide biosynthesis protein
DESME_RS13935	COG2247	cell wall binding repeat
DESME_RS13935	COG2385	sporulation resulting in formation of a cellular spore
DESME_RS13950	COG0640	Transcriptional regulator
DESME_RS13960	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DESME_RS13970	COG0840	transmembrane signaling receptor activity
DESME_RS13975	COG0740	serine-type endopeptidase activity
DESME_RS13985	COG0247	lactate metabolic process
DESME_RS13990	COG0277	FAD linked oxidase domain protein
DESME_RS13995	COG2186	Transcriptional regulator
DESME_RS14000	COG1309	transcriptional regulator
DESME_RS14010	COG2733	membrane
DESME_RS14015	COG2733	membrane
DESME_RS14020	COG3858	chitin binding
DESME_RS14020	COG1388	LysM domain
DESME_RS14025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESME_RS14030	COG0427	acetyl-CoA hydrolase
DESME_RS14035	COG1960	acyl-CoA dehydrogenase activity
DESME_RS14040	COG0183	Belongs to the thiolase family
DESME_RS14045	COG1024	Enoyl-CoA hydratase
DESME_RS14045	COG1250	3-hydroxyacyl-CoA dehydrogenase
DESME_RS14050	COG1309	transcriptional regulator
DESME_RS14055	COG1024	Enoyl-CoA hydratase
DESME_RS14070	COG1012	belongs to the aldehyde dehydrogenase family
DESME_RS14085	COG0791	NLP P60 protein
DESME_RS14090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DESME_RS14090	COG2080	2 iron, 2 sulfur cluster binding
DESME_RS14115	COG2233	PERMEase
DESME_RS14125	COG1126	abc transporter atp-binding protein
DESME_RS14130	COG0765	amino acid transport
DESME_RS14150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DESME_RS14160	COG1733	regulation of RNA biosynthetic process
DESME_RS14180	COG1122	ATPase activity
DESME_RS14200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DESME_RS14205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DESME_RS14210	COG1116	anion transmembrane transporter activity
DESME_RS14215	COG0436	Aminotransferase
DESME_RS14220	COG1773	rubredoxin
DESME_RS14220	COG1592	Rubrerythrin
DESME_RS14225	COG1592	Rubrerythrin
DESME_RS14225	COG1773	rubredoxin
DESME_RS14230	COG0493	'glutamate synthase
DESME_RS14240	COG0437	4 iron, 4 sulfur cluster binding
DESME_RS14245	COG0243	molybdopterin cofactor binding
DESME_RS14255	COG0437	4 iron, 4 sulfur cluster binding
DESME_RS14260	COG0243	molybdopterin cofactor binding
DESME_RS14265	COG2508	Transcriptional regulator
DESME_RS14275	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DESME_RS14285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DESME_RS14290	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DESME_RS14300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DESME_RS14305	COG1846	Transcriptional regulator
DESME_RS14310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESME_RS14315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DESME_RS14325	COG4129	membrane
DESME_RS14330	COG0602	queuosine metabolic process
DESME_RS14335	COG0720	synthase
DESME_RS14345	COG0531	amino acid
DESME_RS14365	COG0708	Exodeoxyribonuclease III
DESME_RS14400	COG0488	(ABC) transporter
DESME_RS14420	COG0697	spore germination
DESME_RS14425	COG0840	transmembrane signaling receptor activity
DESME_RS14435	COG1309	transcriptional regulator
DESME_RS14460	COG1388	LysM domain
DESME_RS14480	COG2195	Cleaves the N-terminal amino acid of tripeptides
DESME_RS14510	COG0577	efflux transmembrane transporter activity
DESME_RS14510	COG1136	(ABC) transporter
DESME_RS14530	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DESME_RS14540	COG0148	phosphopyruvate hydratase activity
DESME_RS14550	COG0149	triose-phosphate isomerase activity
DESME_RS14555	COG0126	phosphoglycerate kinase activity
DESME_RS14560	COG0247	lactate metabolic process
DESME_RS14570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DESME_RS14575	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DESME_RS14585	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DESME_RS14600	COG1032	radical SAM domain protein
DESME_RS14610	COG0561	phosphatase activity
DESME_RS14615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DESME_RS14625	COG0556	nucleotide-excision repair
DESME_RS14635	COG1950	PFAM Membrane protein of
DESME_RS14640	COG1597	lipid kinase activity
DESME_RS14650	COG0793	Belongs to the peptidase S41A family
DESME_RS14650	COG3409	Peptidoglycan-binding domain 1 protein
DESME_RS14655	COG0739	heme binding
DESME_RS14655	COG0741	lytic transglycosylase activity
DESME_RS14655	COG1196	nuclear chromosome segregation
DESME_RS14660	COG2177	Part of the ABC transporter FtsEX involved in
DESME_RS14665	COG2884	Cell division ATP-binding protein ftsE
DESME_RS14670	COG3958	Transketolase
DESME_RS14675	COG3959	Transketolase, thiamine diphosphate binding domain
DESME_RS14680	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DESME_RS14685	COG0653	protein targeting
DESME_RS14690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DESME_RS14705	COG0765	amino acid transport
DESME_RS14710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESME_RS14715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESME_RS14725	COG1040	competence protein
DESME_RS14730	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DESME_RS14735	COG2720	vancomycin resistance protein
DESME_RS14775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DESME_RS14780	COG0297	glycogen (starch) synthase activity
DESME_RS14780	COG0438	transferase activity, transferring glycosyl groups
DESME_RS14790	COG1191	sigma factor activity
DESME_RS14800	COG1077	Cell shape determining protein MreB Mrl
DESME_RS14805	COG1609	Transcriptional regulator
DESME_RS14815	COG2385	sporulation resulting in formation of a cellular spore
DESME_RS14820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DESME_RS14830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DESME_RS14855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DESME_RS14860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DESME_RS14865	COG0356	it plays a direct role in the translocation of protons across the membrane
DESME_RS14880	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DESME_RS14895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DESME_RS14900	COG4475	Protein of unknown function (DUF436)
DESME_RS14905	COG0698	ribose 5-phosphate isomerase
DESME_RS14915	COG1971	Probably functions as a manganese efflux pump
DESME_RS14920	COG0009	L-threonylcarbamoyladenylate synthase
DESME_RS14925	COG2890	protein-(glutamine-N5) methyltransferase activity
DESME_RS14930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DESME_RS14940	COG0739	heme binding
DESME_RS14945	COG1494	fructose-1,6-bisphosphatase
DESME_RS14965	COG2204	response regulator
DESME_RS14970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DESME_RS14975	COG2348	transferase activity, transferring amino-acyl groups
DESME_RS14980	COG0504	CTP synthase activity
DESME_RS15000	COG2959	enzyme of heme biosynthesis
DESME_RS15010	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DESME_RS15020	COG0017	Asparaginyl-tRNA synthetase
DESME_RS15025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DESME_RS15040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DESME_RS15070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESME_RS15075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DESME_RS15085	COG0243	molybdopterin cofactor binding
DESME_RS15115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DESME_RS15120	COG0305	Participates in initiation and elongation during chromosome replication
DESME_RS15125	COG0470	DNA polymerase III
DESME_RS15125	COG1067	ATP-dependent peptidase activity
DESME_RS15145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DESME_RS15150	COG0629	single-stranded DNA binding
DESME_RS15160	COG0012	GTP binding
DESME_RS15175	COG0517	IMP dehydrogenase activity
DESME_RS15185	COG0411	ABC transporter
DESME_RS15215	COG3949	Membrane
DESME_RS15235	COG1475	DNA binding
DESME_RS15240	COG1192	Involved in chromosome partitioning
DESME_RS15245	COG0357	Ribosomal RNA small subunit methyltransferase G
DESME_RS15255	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DESME_RS15260	COG1847	R3H domain protein
DESME_RS15265	COG0706	membrane insertase activity
DESME_RS15270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DESME_RS15275	COG0594	ribonuclease P activity
DESME_RS15310	COG2247	cell wall binding repeat
DESME_RS15310	COG2385	sporulation resulting in formation of a cellular spore
DESME_RS15315	COG3852	Histidine kinase
DESME_RS15325	COG5416	Lipopolysaccharide assembly protein A domain
DESME_RS15380	COG1196	nuclear chromosome segregation
DESME_RS15380	COG0741	lytic transglycosylase activity
DESME_RS15380	COG0739	heme binding
DESME_RS15385	COG4886	Leucine-rich repeat (LRR) protein
DESME_RS15385	COG4932	domain protein
DESME_RS15390	COG1525	nuclease
DESME_RS15395	COG1396	sequence-specific DNA binding
DESME_RS15410	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESME_RS15410	COG2247	cell wall binding repeat
DESME_RS15415	COG4968	Prepilin-type N-terminal cleavage methylation domain
DESME_RS15445	COG3409	Peptidoglycan-binding domain 1 protein
DESME_RS15445	COG3773	Cell wall hydrolase
DESME_RS15450	COG3300	MHYT domain
DESME_RS15450	COG5001	Diguanylate cyclase
DESME_RS15460	COG0726	polysaccharide deacetylase
DESME_RS15485	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DESME_RS15490	COG4191	Histidine kinase