locus-tag	class	description
HRM2_RS00005	COG0592	DNA-directed DNA polymerase activity
HRM2_RS00010	COG0187	DNA topoisomerase II activity
HRM2_RS00020	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HRM2_RS00025	COG0848	biopolymer transport protein
HRM2_RS00030	COG0811	peptide transport
HRM2_RS00035	COG0811	peptide transport
HRM2_RS00045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HRM2_RS00050	COG0436	Aminotransferase
HRM2_RS00060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRM2_RS00085	COG1797	cobyrinic acid a,c-diamide synthase activity
HRM2_RS00095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HRM2_RS00105	COG0534	Mate efflux family protein
HRM2_RS00125	COG3852	Histidine kinase
HRM2_RS00155	COG4134	Bacterial extracellular solute-binding protein
HRM2_RS00170	COG2878	Part of a membrane complex involved in electron transport
HRM2_RS00180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HRM2_RS00205	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRM2_RS00225	COG5598	trimethylamine methyltransferase
HRM2_RS00235	COG5012	cobalamin binding
HRM2_RS00250	COG4974	Belongs to the 'phage' integrase family
HRM2_RS00275	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HRM2_RS00290	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HRM2_RS00300	COG2181	nitrate reductase activity
HRM2_RS00305	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HRM2_RS00310	COG1140	nitrate reductase beta subunit
HRM2_RS00315	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HRM2_RS00320	COG1309	transcriptional regulator
HRM2_RS00335	COG1136	(ABC) transporter
HRM2_RS00345	COG0515	serine threonine protein kinase
HRM2_RS00345	COG2815	serine threonine protein kinase
HRM2_RS00370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRM2_RS00375	COG3604	Transcriptional regulator
HRM2_RS00380	COG0450	alkyl hydroperoxide reductase
HRM2_RS00390	COG1151	hydroxylamine reductase activity
HRM2_RS00410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRM2_RS00420	COG3005	denitrification pathway
HRM2_RS00445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HRM2_RS00460	COG2226	methyltransferase
HRM2_RS00465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRM2_RS00470	COG1837	Belongs to the UPF0109 family
HRM2_RS00475	COG2264	protein methyltransferase activity
HRM2_RS00490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRM2_RS00500	COG1053	succinate dehydrogenase
HRM2_RS00500	COG0431	NADPH-dependent FMN reductase
HRM2_RS00500	COG3976	FMN-binding domain protein
HRM2_RS00505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRM2_RS00510	COG1120	ATPase activity
HRM2_RS00525	COG2363	Small membrane protein
HRM2_RS00560	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HRM2_RS00575	COG0129	dihydroxy-acid dehydratase activity
HRM2_RS00580	COG0277	FAD linked oxidase domain protein
HRM2_RS00590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HRM2_RS00605	COG5598	trimethylamine methyltransferase
HRM2_RS00610	COG2204	response regulator
HRM2_RS00615	COG4191	Histidine kinase
HRM2_RS00635	COG0702	epimerase
HRM2_RS00640	COG0735	belongs to the Fur family
HRM2_RS00645	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HRM2_RS00650	COG2226	methyltransferase
HRM2_RS00655	COG0010	Belongs to the arginase family
HRM2_RS00670	COG1166	arginine decarboxylase activity
HRM2_RS00690	COG0501	Belongs to the peptidase M48B family
HRM2_RS00695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRM2_RS00710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRM2_RS00715	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRM2_RS00720	COG1027	Aspartate ammonia-lyase
HRM2_RS00725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HRM2_RS00730	COG1116	anion transmembrane transporter activity
HRM2_RS00735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRM2_RS00750	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRM2_RS00765	COG3383	formate dehydrogenase (NAD+) activity
HRM2_RS00780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRM2_RS00805	COG3842	ATPase activity
HRM2_RS00825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRM2_RS00830	COG3300	MHYT domain
HRM2_RS00830	COG5001	Diguanylate cyclase
HRM2_RS00840	COG0573	inorganic phosphate transmembrane transporter activity
HRM2_RS00845	COG0581	inorganic phosphate transmembrane transporter activity
HRM2_RS00850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRM2_RS00865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRM2_RS00875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRM2_RS00875	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS00905	COG1785	Belongs to the alkaline phosphatase family
HRM2_RS00940	COG0494	nUDIX hydrolase
HRM2_RS00945	COG1309	transcriptional regulator
HRM2_RS00950	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRM2_RS00950	COG1902	pentaerythritol trinitrate reductase activity
HRM2_RS00960	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HRM2_RS00965	COG0583	DNA-binding transcription factor activity
HRM2_RS00970	COG2221	Nitrite and sulphite reductase 4Fe-4S
HRM2_RS01010	COG2770	Histidine kinase
HRM2_RS01010	COG2208	phosphoserine phosphatase activity
HRM2_RS01020	COG1366	Belongs to the anti-sigma-factor antagonist family
HRM2_RS01030	COG1151	hydroxylamine reductase activity
HRM2_RS01035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRM2_RS01060	COG1595	DNA-templated transcription, initiation
HRM2_RS01085	COG1492	cobalamin metabolic process
HRM2_RS01090	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HRM2_RS01130	COG1120	ATPase activity
HRM2_RS01135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRM2_RS01140	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS01165	COG0730	response to heat
HRM2_RS01170	COG5002	protein histidine kinase activity
HRM2_RS01180	COG3706	GGDEF domain
HRM2_RS01190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRM2_RS01195	COG0581	inorganic phosphate transmembrane transporter activity
HRM2_RS01200	COG0573	inorganic phosphate transmembrane transporter activity
HRM2_RS01205	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRM2_RS01230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HRM2_RS01235	COG0124	histidyl-tRNA synthetase
HRM2_RS01240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRM2_RS01245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRM2_RS01255	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HRM2_RS01260	COG2894	cell division
HRM2_RS01265	COG0850	regulation of cytokinetic process
HRM2_RS01270	COG2205	protein histidine kinase activity
HRM2_RS01270	COG2202	Pas domain
HRM2_RS01275	COG2197	response regulator
HRM2_RS01295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRM2_RS01305	COG0436	Aminotransferase
HRM2_RS01310	COG0303	'Molybdopterin
HRM2_RS01320	COG1910	domain protein
HRM2_RS01325	COG0372	Belongs to the citrate synthase family
HRM2_RS01335	COG0497	DNA recombination
HRM2_RS01370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRM2_RS01380	COG3681	Belongs to the UPF0597 family
HRM2_RS01400	COG1811	Na channel or pump
HRM2_RS01430	COG0243	molybdopterin cofactor binding
HRM2_RS01445	COG1595	DNA-templated transcription, initiation
HRM2_RS01460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HRM2_RS01470	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HRM2_RS01495	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRM2_RS01500	COG1028	Short-chain dehydrogenase reductase Sdr
HRM2_RS01505	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS01520	COG1028	Short-chain dehydrogenase reductase Sdr
HRM2_RS01530	COG1794	racemase activity, acting on amino acids and derivatives
HRM2_RS01535	COG0251	oxidation-reduction process
HRM2_RS01545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRM2_RS01550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRM2_RS01550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRM2_RS01555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRM2_RS01555	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRM2_RS01580	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRM2_RS01590	COG1902	pentaerythritol trinitrate reductase activity
HRM2_RS01590	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRM2_RS01600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HRM2_RS01615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRM2_RS01625	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HRM2_RS01630	COG0765	amino acid transport
HRM2_RS01635	COG1126	abc transporter atp-binding protein
HRM2_RS01645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HRM2_RS01650	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS01660	COG0133	tryptophan synthase activity
HRM2_RS01670	COG0642	Histidine kinase
HRM2_RS01680	COG0243	molybdopterin cofactor binding
HRM2_RS01680	COG3383	formate dehydrogenase (NAD+) activity
HRM2_RS01685	COG3383	formate dehydrogenase (NAD+) activity
HRM2_RS01685	COG0243	molybdopterin cofactor binding
HRM2_RS01690	COG0437	4 iron, 4 sulfur cluster binding
HRM2_RS01710	COG1546	Belongs to the CinA family
HRM2_RS01710	COG1058	Belongs to the CinA family
HRM2_RS01745	COG4302	ethanolamine ammonia-lyase activity
HRM2_RS01750	COG4303	Ethanolamine ammonia lyase large subunit
HRM2_RS01765	COG2264	protein methyltransferase activity
HRM2_RS01795	COG1012	belongs to the aldehyde dehydrogenase family
HRM2_RS01825	COG3459	Glycosyltransferase 36 associated
HRM2_RS01835	COG2823	Periplasmic or secreted lipoprotein
HRM2_RS01845	COG4555	ABC transporter
HRM2_RS01850	COG2433	Pfam Transposase IS66
HRM2_RS01855	COG3436	PFAM IS66 Orf2 family protein
HRM2_RS01880	COG1509	lysine 2,3-aminomutase activity
HRM2_RS01885	COG3064	Membrane
HRM2_RS01915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRM2_RS01925	COG2261	transglycosylase associated protein
HRM2_RS01930	COG0045	succinate-CoA ligase (ADP-forming) activity
HRM2_RS01930	COG1042	CoA-binding domain protein
HRM2_RS01930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRM2_RS01940	COG3576	pyridoxamine 5-phosphate
HRM2_RS01955	COG2951	lytic endotransglycosylase activity
HRM2_RS01960	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HRM2_RS01965	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HRM2_RS01970	COG0217	transcriptional regulatory protein
HRM2_RS01975	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HRM2_RS01980	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS01985	COG0443	Heat shock 70 kDa protein
HRM2_RS01990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRM2_RS02010	COG4942	peptidase
HRM2_RS02015	COG0667	Aldo Keto reductase
HRM2_RS02025	COG1433	Dinitrogenase iron-molybdenum cofactor
HRM2_RS02025	COG0535	radical SAM domain protein
HRM2_RS02100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRM2_RS02105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HRM2_RS02115	COG0351	phosphomethylpyrimidine kinase
HRM2_RS02120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HRM2_RS02125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRM2_RS02140	COG1366	Belongs to the anti-sigma-factor antagonist family
HRM2_RS02155	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRM2_RS02160	COG0740	serine-type endopeptidase activity
HRM2_RS02165	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRM2_RS02170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRM2_RS02185	COG0473	3-isopropylmalate dehydrogenase activity
HRM2_RS02195	COG1024	Enoyl-CoA hydratase
HRM2_RS02205	COG1278	Cold shock
HRM2_RS02215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRM2_RS02220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRM2_RS02250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRM2_RS02255	COG0590	tRNA wobble adenosine to inosine editing
HRM2_RS02260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRM2_RS02265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HRM2_RS02270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HRM2_RS02275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HRM2_RS02280	COG0072	phenylalanine-tRNA ligase activity
HRM2_RS02290	COG0779	Required for maturation of 30S ribosomal subunits
HRM2_RS02300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRM2_RS02305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRM2_RS02310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRM2_RS02315	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HRM2_RS02320	COG1185	polyribonucleotide nucleotidyltransferase activity
HRM2_RS02355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HRM2_RS02370	COG1763	Mo-molybdopterin cofactor biosynthetic process
HRM2_RS02375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRM2_RS02385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRM2_RS02455	COG2186	Transcriptional regulator
HRM2_RS02485	COG0427	acetyl-CoA hydrolase
HRM2_RS02490	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HRM2_RS02500	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRM2_RS02505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRM2_RS02520	COG3842	ATPase activity
HRM2_RS02530	COG1175	transmembrane transport
HRM2_RS02535	COG0395	ABC-type sugar transport system, permease component
HRM2_RS02550	COG1283	sodium-dependent phosphate transmembrane transporter activity
HRM2_RS02560	COG1522	sequence-specific DNA binding
HRM2_RS02565	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HRM2_RS02575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRM2_RS02580	COG0697	spore germination
HRM2_RS02585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRM2_RS02590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRM2_RS02630	COG4807	Protein conserved in bacteria
HRM2_RS02640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRM2_RS02645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HRM2_RS02655	COG3604	Transcriptional regulator
HRM2_RS02660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRM2_RS02670	COG1126	abc transporter atp-binding protein
HRM2_RS02675	COG0765	amino acid transport
HRM2_RS02680	COG4597	amino acid ABC transporter
HRM2_RS02730	COG1203	CRISPR-associated helicase, Cas3
HRM2_RS02755	COG0826	peptidase U32
HRM2_RS02760	COG2814	Major facilitator Superfamily
HRM2_RS02800	COG1595	DNA-templated transcription, initiation
HRM2_RS02825	COG1136	(ABC) transporter
HRM2_RS02825	COG0577	efflux transmembrane transporter activity
HRM2_RS02830	COG1136	(ABC) transporter
HRM2_RS02830	COG0577	efflux transmembrane transporter activity
HRM2_RS02870	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HRM2_RS02890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRM2_RS02900	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HRM2_RS02950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRM2_RS02955	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRM2_RS02960	COG4195	phage-related replication protein
HRM2_RS02965	COG0646	methionine synthase
HRM2_RS02965	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HRM2_RS02980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRM2_RS02990	COG1946	Acyl-CoA thioesterase
HRM2_RS03000	COG3239	Fatty acid desaturase
HRM2_RS03010	COG1592	Rubrerythrin
HRM2_RS03020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRM2_RS03050	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRM2_RS03050	COG1024	Enoyl-CoA hydratase
HRM2_RS03075	COG3845	ABC transporter
HRM2_RS03080	COG4603	Belongs to the binding-protein-dependent transport system permease family
HRM2_RS03085	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRM2_RS03120	COG2267	carboxylic ester hydrolase activity
HRM2_RS03210	COG2264	protein methyltransferase activity
HRM2_RS03225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRM2_RS03230	COG1847	R3H domain protein
HRM2_RS03235	COG0706	membrane insertase activity
HRM2_RS03240	COG0594	ribonuclease P activity
HRM2_RS03245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRM2_RS03250	COG1530	ribonuclease E activity
HRM2_RS03260	COG0017	Asparaginyl-tRNA synthetase
HRM2_RS03270	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HRM2_RS03275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HRM2_RS03310	COG0347	Belongs to the P(II) protein family
HRM2_RS03315	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HRM2_RS03320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRM2_RS03325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRM2_RS03335	COG0084	hydrolase, TatD family'
HRM2_RS03345	COG1045	serine acetyltransferase
HRM2_RS03355	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRM2_RS03360	COG1805	sodium ion transport
HRM2_RS03365	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRM2_RS03370	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRM2_RS03375	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRM2_RS03390	COG0588	phosphoglycerate mutase activity
HRM2_RS03395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRM2_RS03400	COG3608	succinylglutamate desuccinylase aspartoacylase
HRM2_RS03400	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HRM2_RS03445	COG2204	response regulator
HRM2_RS03455	COG0490	domain, Protein
HRM2_RS03455	COG0471	metal ion transport
HRM2_RS03485	COG2204	response regulator
HRM2_RS03495	COG3852	Histidine kinase
HRM2_RS03510	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HRM2_RS03525	COG3549	Plasmid maintenance system killer
HRM2_RS03535	COG1278	Cold shock
HRM2_RS03560	COG2204	response regulator
HRM2_RS03585	COG5012	cobalamin binding
HRM2_RS03635	COG0427	acetyl-CoA hydrolase
HRM2_RS03645	COG5012	cobalamin binding
HRM2_RS03650	COG5598	trimethylamine methyltransferase
HRM2_RS03655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HRM2_RS03660	COG3829	transcription factor binding
HRM2_RS03665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HRM2_RS03690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRM2_RS03710	COG1605	Chorismate mutase
HRM2_RS03710	COG0287	Prephenate dehydrogenase
HRM2_RS03725	COG3588	fructose-bisphosphate aldolase
HRM2_RS03730	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS03735	COG1550	Protein conserved in bacteria
HRM2_RS03750	COG4206	TonB-dependent receptor
HRM2_RS03755	COG4822	anaerobic cobalamin biosynthetic process
HRM2_RS03760	COG4822	anaerobic cobalamin biosynthetic process
HRM2_RS03765	COG1794	racemase activity, acting on amino acids and derivatives
HRM2_RS03770	COG0183	Belongs to the thiolase family
HRM2_RS03775	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS03780	COG1309	transcriptional regulator
HRM2_RS03785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRM2_RS03790	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HRM2_RS03805	COG0471	metal ion transport
HRM2_RS03840	COG0840	transmembrane signaling receptor activity
HRM2_RS03850	COG2204	response regulator
HRM2_RS03890	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HRM2_RS03940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRM2_RS03950	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRM2_RS03960	COG1309	transcriptional regulator
HRM2_RS03965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRM2_RS03970	COG0512	Glutamine amidotransferase of anthranilate synthase
HRM2_RS03990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRM2_RS04000	COG2962	Rard protein
HRM2_RS04065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HRM2_RS04080	COG0577	efflux transmembrane transporter activity
HRM2_RS04080	COG1136	(ABC) transporter
HRM2_RS04130	COG1126	abc transporter atp-binding protein
HRM2_RS04135	COG0765	amino acid transport
HRM2_RS04140	COG0765	amino acid transport
HRM2_RS04145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRM2_RS04150	COG1396	sequence-specific DNA binding
HRM2_RS04155	COG3875	lactate racemase activity
HRM2_RS04165	COG0277	FAD linked oxidase domain protein
HRM2_RS04180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRM2_RS04190	COG2814	Major facilitator Superfamily
HRM2_RS04225	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HRM2_RS04230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRM2_RS04240	COG0191	fructose-bisphosphate aldolase activity
HRM2_RS04245	COG1105	Belongs to the carbohydrate kinase PfkB family
HRM2_RS04250	COG1063	alcohol dehydrogenase
HRM2_RS04255	COG2213	PTS system mannitol-specific
HRM2_RS04255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRM2_RS04270	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HRM2_RS04280	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HRM2_RS04290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRM2_RS04290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRM2_RS04295	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS04300	COG3706	GGDEF domain
HRM2_RS04310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HRM2_RS04315	COG0543	2 iron, 2 sulfur cluster binding
HRM2_RS04335	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HRM2_RS04335	COG0644	oxidoreductase
HRM2_RS04340	COG0427	acetyl-CoA hydrolase
HRM2_RS04345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRM2_RS04350	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS04355	COG1309	transcriptional regulator
HRM2_RS04370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRM2_RS04380	COG1073	alpha beta
HRM2_RS04385	COG4771	TonB-dependent receptor
HRM2_RS04395	COG2814	Major facilitator Superfamily
HRM2_RS04430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRM2_RS04440	COG0156	8-amino-7-oxononanoate synthase activity
HRM2_RS04450	COG1032	radical SAM domain protein
HRM2_RS04455	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HRM2_RS04460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRM2_RS04475	COG5598	trimethylamine methyltransferase
HRM2_RS04490	COG0012	GTP binding
HRM2_RS04495	COG0702	epimerase
HRM2_RS04505	COG0427	acetyl-CoA hydrolase
HRM2_RS04515	COG0521	Mo-molybdopterin cofactor biosynthetic process
HRM2_RS04520	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HRM2_RS04525	COG0746	molybdenum cofactor guanylyltransferase activity
HRM2_RS04535	COG0315	cyclic pyranopterin monophosphate synthase activity
HRM2_RS04540	COG1322	Protein conserved in bacteria
HRM2_RS04560	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRM2_RS04565	COG0151	Belongs to the GarS family
HRM2_RS04570	COG0009	L-threonylcarbamoyladenylate synthase
HRM2_RS04615	COG3093	addiction module antidote protein HigA
HRM2_RS04620	COG3549	Plasmid maintenance system killer
HRM2_RS04715	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HRM2_RS04720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRM2_RS04750	COG0737	Belongs to the 5'-nucleotidase family
HRM2_RS04760	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HRM2_RS04765	COG0347	Belongs to the P(II) protein family
HRM2_RS04770	COG0347	Belongs to the P(II) protein family
HRM2_RS04795	COG0535	radical SAM domain protein
HRM2_RS04795	COG1433	Dinitrogenase iron-molybdenum cofactor
HRM2_RS04805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRM2_RS04820	COG0583	DNA-binding transcription factor activity
HRM2_RS04850	COG0725	ABC transporter, periplasmic molybdate-binding protein
HRM2_RS04855	COG4149	molybdate abc transporter
HRM2_RS04860	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HRM2_RS04870	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRM2_RS04880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HRM2_RS04905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRM2_RS04920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRM2_RS04925	COG1024	Enoyl-CoA hydratase
HRM2_RS04930	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS04935	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS04940	COG1309	transcriptional regulator
HRM2_RS04945	COG1703	isobutyryl-CoA mutase activity
HRM2_RS04945	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRM2_RS04945	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRM2_RS04955	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRM2_RS04975	COG1902	pentaerythritol trinitrate reductase activity
HRM2_RS04985	COG2130	NADP-dependent
HRM2_RS04990	COG1979	alcohol dehydrogenase
HRM2_RS05010	COG2815	serine threonine protein kinase
HRM2_RS05010	COG0515	serine threonine protein kinase
HRM2_RS05020	COG1162	GTPase activity
HRM2_RS05040	COG0840	transmembrane signaling receptor activity
HRM2_RS05055	COG0598	Magnesium transport protein CorA
HRM2_RS05065	COG0861	Integral membrane protein TerC family
HRM2_RS05075	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HRM2_RS05080	COG0114	fumarate hydratase activity
HRM2_RS05090	COG0346	lactoylglutathione lyase activity
HRM2_RS05120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRM2_RS05135	COG2366	antibiotic biosynthetic process
HRM2_RS05140	COG2205	protein histidine kinase activity
HRM2_RS05145	COG0745	RESPONSE REGULATOR receiver
HRM2_RS05155	COG1368	sulfuric ester hydrolase activity
HRM2_RS05165	COG2204	response regulator
HRM2_RS05190	COG1047	Peptidyl-prolyl cis-trans
HRM2_RS05200	COG1283	sodium-dependent phosphate transmembrane transporter activity
HRM2_RS05230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRM2_RS05245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRM2_RS05255	COG0023	Translation Initiation Factor
HRM2_RS05290	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS05300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRM2_RS05320	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HRM2_RS05325	COG0436	Aminotransferase
HRM2_RS05330	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRM2_RS05335	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRM2_RS05350	COG0571	ribonuclease III activity
HRM2_RS05360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HRM2_RS05365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRM2_RS05370	COG1648	precorrin-2 dehydrogenase activity
HRM2_RS05370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRM2_RS05390	COG0735	belongs to the Fur family
HRM2_RS05395	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HRM2_RS05395	COG1918	ferrous iron import across plasma membrane
HRM2_RS05400	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRM2_RS05400	COG4991	sh3 domain protein
HRM2_RS05400	COG3103	Sh3 type 3 domain protein
HRM2_RS05415	COG2204	response regulator
HRM2_RS05420	COG5002	protein histidine kinase activity
HRM2_RS05460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HRM2_RS05465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRM2_RS05470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRM2_RS05475	COG0490	domain, Protein
HRM2_RS05480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRM2_RS05485	COG1238	metal cluster binding
HRM2_RS05500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HRM2_RS05505	COG0742	ribosomal rna small subunit methyltransferase
HRM2_RS05515	COG5000	phosphorelay sensor kinase activity
HRM2_RS05525	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HRM2_RS05530	COG0606	chelatase, subunit chli
HRM2_RS05535	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HRM2_RS05555	COG1459	type II secretion system
HRM2_RS05560	COG4279	zinc finger
HRM2_RS05565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRM2_RS05575	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HRM2_RS05580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRM2_RS05640	COG2226	methyltransferase
HRM2_RS05645	COG0484	heat shock protein binding
HRM2_RS05650	COG0720	synthase
HRM2_RS05655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HRM2_RS05660	COG2884	Cell division ATP-binding protein ftsE
HRM2_RS05665	COG2177	Part of the ABC transporter FtsEX involved in
HRM2_RS05675	COG0793	Belongs to the peptidase S41A family
HRM2_RS05680	COG2861	carbohydrate metabolic process
HRM2_RS05685	COG2264	protein methyltransferase activity
HRM2_RS05690	COG2264	protein methyltransferase activity
HRM2_RS05705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRM2_RS05730	COG0298	carbon dioxide binding
HRM2_RS05735	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HRM2_RS05740	COG0409	Hydrogenase expression formation protein
HRM2_RS05755	COG1012	belongs to the aldehyde dehydrogenase family
HRM2_RS05760	COG3118	belongs to the thioredoxin family
HRM2_RS05765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HRM2_RS05770	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HRM2_RS05795	COG0644	oxidoreductase
HRM2_RS05805	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
HRM2_RS05815	COG3706	GGDEF domain
HRM2_RS05830	COG4628	conserved protein (DUF2132)
HRM2_RS05845	COG4566	intracellular signal transduction
HRM2_RS05850	COG5002	protein histidine kinase activity
HRM2_RS05855	COG0745	RESPONSE REGULATOR receiver
HRM2_RS05860	COG1233	COG1233 Phytoene dehydrogenase and related
HRM2_RS05865	COG1233	COG1233 Phytoene dehydrogenase and related
HRM2_RS05880	COG3383	formate dehydrogenase (NAD+) activity
HRM2_RS05885	COG3383	formate dehydrogenase (NAD+) activity
HRM2_RS05890	COG1639	'signal transduction protein
HRM2_RS05905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRM2_RS05920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRM2_RS05930	COG0084	hydrolase, TatD family'
HRM2_RS05935	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRM2_RS05955	COG4948	Mandelate Racemase Muconate Lactonizing
HRM2_RS05990	COG3852	Histidine kinase
HRM2_RS06005	COG0730	response to heat
HRM2_RS06020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRM2_RS06025	COG1121	(ABC) transporter
HRM2_RS06030	COG1473	amidohydrolase
HRM2_RS06065	COG1253	flavin adenine dinucleotide binding
HRM2_RS06080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRM2_RS06090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRM2_RS06095	COG0442	prolyl-tRNA aminoacylation
HRM2_RS06105	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRM2_RS06110	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRM2_RS06120	COG3118	belongs to the thioredoxin family
HRM2_RS06125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRM2_RS06140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRM2_RS06140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRM2_RS06150	COG0539	negative regulation of cytoplasmic translation
HRM2_RS06155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRM2_RS06160	COG0574	Belongs to the PEP-utilizing enzyme family
HRM2_RS06160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRM2_RS06175	COG0542	response to heat
HRM2_RS06180	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HRM2_RS06185	COG0506	proline dehydrogenase activity
HRM2_RS06195	COG0604	alcohol dehydrogenase
HRM2_RS06245	COG0702	epimerase
HRM2_RS06260	COG2001	Belongs to the MraZ family
HRM2_RS06265	COG0275	rRNA processing
HRM2_RS06270	COG4839	cell division protein FtsL
HRM2_RS06280	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRM2_RS06285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRM2_RS06290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRM2_RS06295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HRM2_RS06305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRM2_RS06310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRM2_RS06315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRM2_RS06330	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HRM2_RS06355	COG2897	thiosulfate sulfurtransferase activity
HRM2_RS06400	COG4608	Belongs to the ABC transporter superfamily
HRM2_RS06405	COG0444	Belongs to the ABC transporter superfamily
HRM2_RS06410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRM2_RS06415	COG0601	transmembrane transport
HRM2_RS06425	COG1473	amidohydrolase
HRM2_RS06435	COG0392	lysyltransferase activity
HRM2_RS06455	COG2239	Acts as a magnesium transporter
HRM2_RS06460	COG2095	MarC family integral membrane protein
HRM2_RS06490	COG1222	aaa ATPase
HRM2_RS06565	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRM2_RS06570	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRM2_RS06575	COG1509	lysine 2,3-aminomutase activity
HRM2_RS06585	COG2204	response regulator
HRM2_RS06615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRM2_RS06625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRM2_RS06655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRM2_RS06670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRM2_RS06675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRM2_RS06680	COG1120	ATPase activity
HRM2_RS06715	COG0012	GTP binding
HRM2_RS06730	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HRM2_RS06730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRM2_RS06745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRM2_RS06750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRM2_RS06760	COG0697	spore germination
HRM2_RS06790	COG1454	alcohol dehydrogenase
HRM2_RS06795	COG5002	protein histidine kinase activity
HRM2_RS06800	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS06805	COG2205	protein histidine kinase activity
HRM2_RS06805	COG0784	Response regulator, receiver
HRM2_RS06805	COG5002	protein histidine kinase activity
HRM2_RS06815	COG4585	Histidine kinase
HRM2_RS06820	COG2197	response regulator
HRM2_RS06825	COG0281	malic enzyme
HRM2_RS06830	COG3842	ATPase activity
HRM2_RS06835	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRM2_RS06840	COG1177	transmembrane transport
HRM2_RS06850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRM2_RS06855	COG2308	Evidence 4 Homologs of previously reported genes of
HRM2_RS06890	COG1215	transferase activity, transferring glycosyl groups
HRM2_RS06915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRM2_RS06915	COG4651	solute:proton antiporter activity
HRM2_RS06920	COG0436	Aminotransferase
HRM2_RS06945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRM2_RS06955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRM2_RS06960	COG0247	lactate metabolic process
HRM2_RS06965	COG1139	Iron-sulfur cluster binding protein
HRM2_RS06970	COG1556	Lactate utilization protein
HRM2_RS06985	COG1126	abc transporter atp-binding protein
HRM2_RS07015	COG4251	negative regulation of phosphorylation
HRM2_RS07015	COG2203	Gaf domain
HRM2_RS07015	COG3706	GGDEF domain
HRM2_RS07015	COG5001	Diguanylate cyclase
HRM2_RS07025	COG1177	transmembrane transport
HRM2_RS07030	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRM2_RS07035	COG3842	ATPase activity
HRM2_RS07050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRM2_RS07060	COG2204	response regulator
HRM2_RS07070	COG5012	cobalamin binding
HRM2_RS07080	COG1063	alcohol dehydrogenase
HRM2_RS07095	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HRM2_RS07105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRM2_RS07130	COG2414	aldehyde ferredoxin oxidoreductase
HRM2_RS07140	COG1233	COG1233 Phytoene dehydrogenase and related
HRM2_RS07155	COG1139	Iron-sulfur cluster binding protein
HRM2_RS07160	COG3383	formate dehydrogenase (NAD+) activity
HRM2_RS07185	COG0417	DNA replication proofreading
HRM2_RS07210	COG1136	(ABC) transporter
HRM2_RS07250	COG1090	epimerase
HRM2_RS07255	COG1294	oxidase, subunit
HRM2_RS07260	COG1271	oxidase subunit
HRM2_RS07270	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRM2_RS07275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRM2_RS07340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRM2_RS07405	COG1846	Transcriptional regulator
HRM2_RS07425	COG1053	succinate dehydrogenase
HRM2_RS07430	COG2814	Major facilitator Superfamily
HRM2_RS07455	COG1028	Short-chain dehydrogenase reductase Sdr
HRM2_RS07460	COG3321	synthase
HRM2_RS07460	COG0604	alcohol dehydrogenase
HRM2_RS07465	COG1733	regulation of RNA biosynthetic process
HRM2_RS07490	COG2217	Heavy metal translocating P-type atpase
HRM2_RS07545	COG0437	4 iron, 4 sulfur cluster binding
HRM2_RS07550	COG2226	methyltransferase
HRM2_RS07580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HRM2_RS07585	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS07615	COG0765	amino acid transport
HRM2_RS07620	COG0765	amino acid transport
HRM2_RS07630	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HRM2_RS07640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRM2_RS07645	COG0352	thiamine-phosphate diphosphorylase activity
HRM2_RS07650	COG4251	negative regulation of phosphorylation
HRM2_RS07650	COG3706	GGDEF domain
HRM2_RS07650	COG2203	Gaf domain
HRM2_RS07650	COG5001	Diguanylate cyclase
HRM2_RS07665	COG1454	alcohol dehydrogenase
HRM2_RS07675	COG4191	Histidine kinase
HRM2_RS07680	COG1454	alcohol dehydrogenase
HRM2_RS07685	COG0501	Belongs to the peptidase M48B family
HRM2_RS07700	COG0588	phosphoglycerate mutase activity
HRM2_RS07705	COG0351	phosphomethylpyrimidine kinase
HRM2_RS07725	COG0668	transmembrane transport
HRM2_RS07730	COG1331	Highly conserved protein containing a thioredoxin domain
HRM2_RS07755	COG1538	Outer membrane efflux protein
HRM2_RS07765	COG1131	(ABC) transporter
HRM2_RS07770	COG0842	Transport permease protein
HRM2_RS07775	COG0842	Transport permease protein
HRM2_RS07780	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HRM2_RS07785	COG1802	Transcriptional regulator
HRM2_RS07790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRM2_RS07805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRM2_RS07820	COG3290	protein histidine kinase activity
HRM2_RS07860	COG0348	domain, Protein
HRM2_RS07870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRM2_RS07890	COG2204	response regulator
HRM2_RS07895	COG0531	amino acid
HRM2_RS07905	COG5012	cobalamin binding
HRM2_RS07925	COG3706	GGDEF domain
HRM2_RS07930	COG0426	domain, Protein
HRM2_RS07935	COG0427	acetyl-CoA hydrolase
HRM2_RS07965	COG0840	transmembrane signaling receptor activity
HRM2_RS07975	COG0427	acetyl-CoA hydrolase
HRM2_RS07980	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS07985	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRM2_RS08035	COG1120	ATPase activity
HRM2_RS08040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRM2_RS08045	COG4206	TonB-dependent receptor
HRM2_RS08070	COG0574	Belongs to the PEP-utilizing enzyme family
HRM2_RS08070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRM2_RS08080	COG1132	(ABC) transporter
HRM2_RS08090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRM2_RS08095	COG0577	efflux transmembrane transporter activity
HRM2_RS08095	COG1136	(ABC) transporter
HRM2_RS08100	COG0577	efflux transmembrane transporter activity
HRM2_RS08100	COG1136	(ABC) transporter
HRM2_RS08110	COG0569	domain protein
HRM2_RS08115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRM2_RS08130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HRM2_RS08155	COG1846	Transcriptional regulator
HRM2_RS08170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRM2_RS08175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HRM2_RS08180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HRM2_RS08190	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HRM2_RS08200	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS08280	COG1151	hydroxylamine reductase activity
HRM2_RS08295	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HRM2_RS08300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRM2_RS08305	COG3404	Formiminotransferase-cyclodeaminase
HRM2_RS08310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HRM2_RS08340	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HRM2_RS08350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRM2_RS08355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HRM2_RS08365	COG1329	Transcriptional regulator
HRM2_RS08370	COG0564	pseudouridine synthase activity
HRM2_RS08380	COG3383	formate dehydrogenase (NAD+) activity
HRM2_RS08385	COG3383	formate dehydrogenase (NAD+) activity
HRM2_RS08390	COG1012	belongs to the aldehyde dehydrogenase family
HRM2_RS08395	COG3383	formate dehydrogenase (NAD+) activity
HRM2_RS08400	COG3383	formate dehydrogenase (NAD+) activity
HRM2_RS08405	COG1245	4Fe-4S binding domain
HRM2_RS08405	COG2878	Part of a membrane complex involved in electron transport
HRM2_RS08415	COG1227	inorganic diphosphatase activity
HRM2_RS08425	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HRM2_RS08430	COG1674	ftsk spoiiie
HRM2_RS08440	COG0640	Transcriptional regulator
HRM2_RS08460	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS08470	COG0285	dihydrofolate synthase activity
HRM2_RS08475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRM2_RS08480	COG0563	adenylate kinase activity
HRM2_RS08485	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HRM2_RS08490	COG0254	rRNA binding
HRM2_RS08495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRM2_RS08500	COG2890	protein-(glutamine-N5) methyltransferase activity
HRM2_RS08505	COG0052	Belongs to the universal ribosomal protein uS2 family
HRM2_RS08510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRM2_RS08515	COG0528	UMP kinase activity
HRM2_RS08520	COG0233	cytoplasmic translational termination
HRM2_RS08525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRM2_RS08535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRM2_RS08540	COG0750	zinc metalloprotease
HRM2_RS08545	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRM2_RS08550	COG0047	phosphoribosylformylglycinamidine synthase activity
HRM2_RS08555	COG4195	phage-related replication protein
HRM2_RS08560	COG4195	phage-related replication protein
HRM2_RS08565	COG0456	acetyltransferase
HRM2_RS08570	COG2373	Large extracellular alpha-helical protein
HRM2_RS08575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRM2_RS08580	COG5002	protein histidine kinase activity
HRM2_RS08615	COG2356	endonuclease I
HRM2_RS08620	COG4974	Belongs to the 'phage' integrase family
HRM2_RS08680	COG0590	tRNA wobble adenosine to inosine editing
HRM2_RS08685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRM2_RS08710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HRM2_RS08715	COG0668	transmembrane transport
HRM2_RS08730	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS08740	COG1842	Phage shock protein A
HRM2_RS08750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRM2_RS08770	COG4662	Binding-protein-dependent transport system inner membrane component
HRM2_RS08775	COG2998	abc-type tungstate transport system, permease component
HRM2_RS08800	COG1705	Flagellar rod assembly protein muramidase FlgJ
HRM2_RS08800	COG1388	LysM domain
HRM2_RS08805	COG0134	indole-3-glycerol-phosphate synthase activity
HRM2_RS08810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRM2_RS08815	COG0512	Glutamine amidotransferase of anthranilate synthase
HRM2_RS08815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRM2_RS08820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRM2_RS08835	COG1272	protein, Hemolysin III
HRM2_RS08850	COG4864	UPF0365 protein
HRM2_RS08860	COG0494	nUDIX hydrolase
HRM2_RS08875	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRM2_RS08880	COG0356	it plays a direct role in the translocation of protons across the membrane
HRM2_RS08895	COG0709	Synthesizes selenophosphate from selenide and ATP
HRM2_RS08905	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HRM2_RS08905	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRM2_RS08910	COG1607	acyl-coa hydrolase
HRM2_RS08935	COG0582	viral genome integration into host DNA
HRM2_RS08945	COG0513	Belongs to the DEAD box helicase family
HRM2_RS08970	COG1606	tRNA processing
HRM2_RS08975	COG0105	UTP biosynthetic process
HRM2_RS08990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRM2_RS08995	COG0066	3-isopropylmalate dehydratase activity
HRM2_RS09000	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HRM2_RS09005	COG1564	THIamine pyrophosphokinase
HRM2_RS09030	COG1663	tetraacyldisaccharide 4'-kinase activity
HRM2_RS09035	COG1560	Kdo2-lipid A biosynthetic process
HRM2_RS09050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRM2_RS09065	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HRM2_RS09065	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRM2_RS09105	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HRM2_RS09110	COG1519	Transferase
HRM2_RS09115	COG1132	(ABC) transporter
HRM2_RS09125	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRM2_RS09135	COG0463	Glycosyl transferase, family 2
HRM2_RS09140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRM2_RS09150	COG3842	ATPase activity
HRM2_RS09160	COG0395	ABC-type sugar transport system, permease component
HRM2_RS09190	COG1561	YicC-like family, N-terminal region
HRM2_RS09195	COG2052	Domain of unknown function (DUF370)
HRM2_RS09200	COG0194	GDP metabolic process
HRM2_RS09205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRM2_RS09215	COG0538	isocitrate dehydrogenase activity
HRM2_RS09220	COG1040	competence protein
HRM2_RS09230	COG1942	4-Oxalocrotonate Tautomerase
HRM2_RS09240	COG2183	response to ionizing radiation
HRM2_RS09245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRM2_RS09250	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HRM2_RS09255	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRM2_RS09260	COG0277	FAD linked oxidase domain protein
HRM2_RS09275	COG0305	Participates in initiation and elongation during chromosome replication
HRM2_RS09280	COG0359	binds to the 23S rRNA
HRM2_RS09290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRM2_RS09295	COG0360	Binds together with S18 to 16S ribosomal RNA
HRM2_RS09300	COG0488	(ABC) transporter
HRM2_RS09320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRM2_RS09330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRM2_RS09335	COG0612	Peptidase, M16
HRM2_RS09345	COG0252	asparaginase activity
HRM2_RS09350	COG2137	regulation of response to DNA damage stimulus
HRM2_RS09370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRM2_RS09380	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HRM2_RS09405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRM2_RS09405	COG0519	Catalyzes the synthesis of GMP from XMP
HRM2_RS09410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRM2_RS09415	COG0784	Response regulator, receiver
HRM2_RS09415	COG2205	protein histidine kinase activity
HRM2_RS09415	COG5002	protein histidine kinase activity
HRM2_RS09425	COG1333	cytochrome c biogenesis protein
HRM2_RS09430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRM2_RS09440	COG0243	molybdopterin cofactor binding
HRM2_RS09445	COG0437	4 iron, 4 sulfur cluster binding
HRM2_RS09450	COG5557	Pfam Polysulphide reductase, NrfD
HRM2_RS09460	COG0584	glycerophosphoryl diester phosphodiesterase
HRM2_RS09465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRM2_RS09475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRM2_RS09505	COG0582	viral genome integration into host DNA
HRM2_RS09515	COG0776	regulation of translation
HRM2_RS09530	COG1476	TRANSCRIPTIONal
HRM2_RS09645	COG2003	Belongs to the UPF0758 family
HRM2_RS09685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HRM2_RS09690	COG1451	nucleotide metabolic process
HRM2_RS09715	COG2204	response regulator
HRM2_RS09720	COG4191	Histidine kinase
HRM2_RS09720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRM2_RS09735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HRM2_RS09760	COG0489	protein tyrosine kinase activity
HRM2_RS09765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRM2_RS09770	COG1596	polysaccharide export
HRM2_RS09885	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS09900	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS09905	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS09930	COG2362	D-Aminopeptidase
HRM2_RS09960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRM2_RS09975	COG0215	cysteine-tRNA ligase activity
HRM2_RS09985	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HRM2_RS10005	COG1136	(ABC) transporter
HRM2_RS10065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRM2_RS10080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRM2_RS10085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRM2_RS10100	COG0765	amino acid transport
HRM2_RS10105	COG0277	FAD linked oxidase domain protein
HRM2_RS10110	COG0247	lactate metabolic process
HRM2_RS10125	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS10145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRM2_RS10150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRM2_RS10180	COG2204	response regulator
HRM2_RS10190	COG5002	protein histidine kinase activity
HRM2_RS10200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRM2_RS10205	COG1061	Type III restriction enzyme res subunit
HRM2_RS10210	COG1002	Type II restriction enzyme, methylase subunits
HRM2_RS10230	COG2003	Belongs to the UPF0758 family
HRM2_RS10290	COG0789	Transcriptional regulator
HRM2_RS10325	COG0582	viral genome integration into host DNA
HRM2_RS10335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRM2_RS10345	COG0525	valine-tRNA ligase activity
HRM2_RS10350	COG3706	GGDEF domain
HRM2_RS10355	COG0481	GTPase activity
HRM2_RS10360	COG2358	TRAP transporter, solute receptor (TAXI family
HRM2_RS10375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRM2_RS10380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRM2_RS10385	COG0440	acetolactate synthase activity
HRM2_RS10390	COG0028	Belongs to the TPP enzyme family
HRM2_RS10395	COG0129	dihydroxy-acid dehydratase activity
HRM2_RS10400	COG1691	(AIR) carboxylase
HRM2_RS10420	COG1119	ATPase activity
HRM2_RS10425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRM2_RS10435	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS10500	COG0427	acetyl-CoA hydrolase
HRM2_RS10555	COG0545	Peptidyl-prolyl cis-trans isomerase
HRM2_RS10590	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS10595	COG3108	Peptidase M15
HRM2_RS10610	COG0484	heat shock protein binding
HRM2_RS10635	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HRM2_RS10640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRM2_RS10655	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRM2_RS10660	COG4172	Belongs to the ABC transporter superfamily
HRM2_RS10665	COG0747	negative chemotaxis
HRM2_RS10670	COG0601	transmembrane transport
HRM2_RS10680	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HRM2_RS10705	COG0427	acetyl-CoA hydrolase
HRM2_RS10710	COG1091	dTDP-4-dehydrorhamnose reductase activity
HRM2_RS10715	COG0058	SHG alpha-glucan phosphorylase activity
HRM2_RS10720	COG1309	transcriptional regulator
HRM2_RS10735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRM2_RS10735	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HRM2_RS10745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRM2_RS10750	COG0024	Methionine aminopeptidase
HRM2_RS10755	COG1966	Carbon starvation protein
HRM2_RS10770	COG0003	Pfam Anion-transporting ATPase
HRM2_RS10785	COG2848	UPF0210 protein
HRM2_RS10790	COG3830	Belongs to the UPF0237 family
HRM2_RS10800	COG0617	tRNA 3'-terminal CCA addition
HRM2_RS10800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HRM2_RS10800	COG3620	sequence-specific DNA binding
HRM2_RS10805	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS10815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HRM2_RS10855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRM2_RS10860	COG0658	competence protein
HRM2_RS10860	COG2333	competence protein COMEC
HRM2_RS10880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRM2_RS10885	COG1127	ABC transporter
HRM2_RS10910	COG1522	sequence-specific DNA binding
HRM2_RS10915	COG2920	part of a sulfur-relay system
HRM2_RS10955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRM2_RS10990	COG0101	tRNA pseudouridine synthase activity
HRM2_RS10995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HRM2_RS11025	COG0501	Belongs to the peptidase M48B family
HRM2_RS11030	COG1215	transferase activity, transferring glycosyl groups
HRM2_RS11035	COG2205	protein histidine kinase activity
HRM2_RS11050	COG0180	Tryptophanyl-tRNA synthetase
HRM2_RS11055	COG3620	sequence-specific DNA binding
HRM2_RS11055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HRM2_RS11055	COG0617	tRNA 3'-terminal CCA addition
HRM2_RS11065	COG1459	type II secretion system
HRM2_RS11070	COG4191	Histidine kinase
HRM2_RS11075	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HRM2_RS11080	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HRM2_RS11085	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HRM2_RS11090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRM2_RS11100	COG1136	(ABC) transporter
HRM2_RS11105	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRM2_RS11115	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRM2_RS11120	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRM2_RS11125	COG3494	Protein of unknown function (DUF1009)
HRM2_RS11130	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRM2_RS11135	COG4536	flavin adenine dinucleotide binding
HRM2_RS11140	COG1605	Chorismate mutase
HRM2_RS11140	COG0077	Prephenate dehydratase
HRM2_RS11145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRM2_RS11150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRM2_RS11155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRM2_RS11160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRM2_RS11200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRM2_RS11215	COG1178	ABC-type Fe3 transport system permease component
HRM2_RS11220	COG3842	ATPase activity
HRM2_RS11225	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRM2_RS11235	COG1752	Esterase of the alpha-beta hydrolase superfamily
HRM2_RS11240	COG3852	Histidine kinase
HRM2_RS11245	COG0022	dehydrogenase e1 component
HRM2_RS11250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HRM2_RS11255	COG0432	Pfam Uncharacterised protein family UPF0047
HRM2_RS11260	COG2204	response regulator
HRM2_RS11285	COG2204	response regulator
HRM2_RS11325	COG0367	asparagine synthase
HRM2_RS11330	COG4948	Mandelate Racemase Muconate Lactonizing
HRM2_RS11340	COG3273	potassium ion transport
HRM2_RS11340	COG0471	metal ion transport
HRM2_RS11345	COG0668	transmembrane transport
HRM2_RS11360	COG0011	TIGRFAM Protein of
HRM2_RS11390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRM2_RS11390	COG0574	Belongs to the PEP-utilizing enzyme family
HRM2_RS11405	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS11415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRM2_RS11420	COG0765	amino acid transport
HRM2_RS11435	COG3267	Type II secretory pathway component ExeA
HRM2_RS11435	COG3409	Peptidoglycan-binding domain 1 protein
HRM2_RS11440	COG1088	dTDP-glucose 4,6-dehydratase activity
HRM2_RS11445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRM2_RS11445	COG0574	Belongs to the PEP-utilizing enzyme family
HRM2_RS11450	COG0488	(ABC) transporter
HRM2_RS11460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRM2_RS11475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRM2_RS11480	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HRM2_RS11485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRM2_RS11490	COG0424	maF-like protein
HRM2_RS11500	COG0513	Belongs to the DEAD box helicase family
HRM2_RS11520	COG0310	cobalt ion transport
HRM2_RS11530	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HRM2_RS11535	COG1122	ATPase activity
HRM2_RS11540	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HRM2_RS11545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRM2_RS11550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRM2_RS11555	COG4106	trans-aconitate 2-methyltransferase activity
HRM2_RS11560	COG0154	amidase activity
HRM2_RS11565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRM2_RS11570	COG0215	cysteine-tRNA ligase activity
HRM2_RS11575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRM2_RS11580	COG0556	nucleotide-excision repair
HRM2_RS11585	COG0322	excinuclease ABC activity
HRM2_RS11590	COG0561	phosphatase activity
HRM2_RS11595	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HRM2_RS11625	COG1611	Belongs to the LOG family
HRM2_RS11640	COG1067	ATP-dependent peptidase activity
HRM2_RS11645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRM2_RS11660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRM2_RS11665	COG0596	Alpha beta hydrolase
HRM2_RS11670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRM2_RS11705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRM2_RS11710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HRM2_RS11715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRM2_RS11735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRM2_RS11745	COG1192	Involved in chromosome partitioning
HRM2_RS11770	COG1408	metallophosphoesterase
HRM2_RS11790	COG0346	lactoylglutathione lyase activity
HRM2_RS11795	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HRM2_RS11810	COG4656	Part of a membrane complex involved in electron transport
HRM2_RS11815	COG4658	electron transport chain
HRM2_RS11820	COG4659	FMN binding
HRM2_RS11825	COG4660	Part of a membrane complex involved in electron transport
HRM2_RS11830	COG4657	Part of a membrane complex involved in electron transport
HRM2_RS11840	COG0427	acetyl-CoA hydrolase
HRM2_RS11870	COG0427	acetyl-CoA hydrolase
HRM2_RS11885	COG1024	Enoyl-CoA hydratase
HRM2_RS11895	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HRM2_RS11925	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRM2_RS11930	COG0489	protein tyrosine kinase activity
HRM2_RS11945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRM2_RS11955	COG1842	Phage shock protein A
HRM2_RS11975	COG0519	Catalyzes the synthesis of GMP from XMP
HRM2_RS11985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRM2_RS12000	COG1309	transcriptional regulator
HRM2_RS12010	COG1278	Cold shock
HRM2_RS12015	COG0058	SHG alpha-glucan phosphorylase activity
HRM2_RS12040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRM2_RS12045	COG2197	response regulator
HRM2_RS12070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRM2_RS12070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HRM2_RS12075	COG3100	YcgL domain-containing protein
HRM2_RS12075	COG0561	phosphatase activity
HRM2_RS12080	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS12095	COG0640	Transcriptional regulator
HRM2_RS12115	COG0243	molybdopterin cofactor binding
HRM2_RS12120	COG1846	Transcriptional regulator
HRM2_RS12150	COG1129	ABC transporter
HRM2_RS12155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRM2_RS12185	COG0308	aminopeptidase N
HRM2_RS12210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRM2_RS12220	COG0477	Major facilitator Superfamily
HRM2_RS12225	COG0517	IMP dehydrogenase activity
HRM2_RS12250	COG1678	Uncharacterized ACR, COG1678
HRM2_RS12270	COG0484	heat shock protein binding
HRM2_RS12280	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRM2_RS12300	COG3876	Protein conserved in bacteria
HRM2_RS12310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HRM2_RS12315	COG2183	response to ionizing radiation
HRM2_RS12315	COG0539	negative regulation of cytoplasmic translation
HRM2_RS12320	COG0616	signal peptide processing
HRM2_RS12325	COG0009	L-threonylcarbamoyladenylate synthase
HRM2_RS12330	COG0517	IMP dehydrogenase activity
HRM2_RS12330	COG0516	GMP reductase activity
HRM2_RS12350	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HRM2_RS12365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRM2_RS12370	COG0357	Ribosomal RNA small subunit methyltransferase G
HRM2_RS12375	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRM2_RS12380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRM2_RS12405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRM2_RS12410	COG0321	lipoyl(octanoyl) transferase activity
HRM2_RS12415	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRM2_RS12420	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRM2_RS12425	COG0509	glycine decarboxylation via glycine cleavage system
HRM2_RS12430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRM2_RS12435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRM2_RS12460	COG0559	Belongs to the binding-protein-dependent transport system permease family
HRM2_RS12470	COG0542	response to heat
HRM2_RS12475	COG2204	response regulator
HRM2_RS12485	COG0530	calcium, potassium:sodium antiporter activity
HRM2_RS12490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRM2_RS12495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRM2_RS12500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRM2_RS12510	COG0529	Catalyzes the synthesis of activated sulfate
HRM2_RS12510	COG2046	Belongs to the sulfate adenylyltransferase family
HRM2_RS12530	COG2046	Belongs to the sulfate adenylyltransferase family
HRM2_RS12530	COG0529	Catalyzes the synthesis of activated sulfate
HRM2_RS12570	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS12610	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS12615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRM2_RS12620	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS12620	COG0297	glycogen (starch) synthase activity
HRM2_RS12660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRM2_RS12720	COG3206	protein involved in exopolysaccharide biosynthesis
HRM2_RS12720	COG0489	protein tyrosine kinase activity
HRM2_RS12755	COG0670	Belongs to the BI1 family
HRM2_RS12765	COG1722	exodeoxyribonuclease VII activity
HRM2_RS12775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRM2_RS12780	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HRM2_RS12785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRM2_RS12790	COG1028	Short-chain dehydrogenase reductase Sdr
HRM2_RS12820	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRM2_RS12835	COG0247	lactate metabolic process
HRM2_RS12845	COG0745	RESPONSE REGULATOR receiver
HRM2_RS12855	COG2204	response regulator
HRM2_RS12860	COG2153	protein acetylation
HRM2_RS12880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRM2_RS12880	COG0551	DNA topoisomerase type I activity
HRM2_RS12885	COG1028	Short-chain dehydrogenase reductase Sdr
HRM2_RS12890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRM2_RS12955	COG0515	serine threonine protein kinase
HRM2_RS12955	COG2815	serine threonine protein kinase
HRM2_RS13040	COG4974	Belongs to the 'phage' integrase family
HRM2_RS13050	COG4974	Belongs to the 'phage' integrase family
HRM2_RS13055	COG3344	reverse transcriptase
HRM2_RS13110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRM2_RS13115	COG1074	ATP-dependent DNA helicase activity
HRM2_RS13120	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HRM2_RS13130	COG0564	pseudouridine synthase activity
HRM2_RS13140	COG1643	Atp-dependent helicase
HRM2_RS13150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRM2_RS13170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRM2_RS13180	COG1058	Belongs to the CinA family
HRM2_RS13180	COG1546	Belongs to the CinA family
HRM2_RS13185	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HRM2_RS13190	COG0739	heme binding
HRM2_RS13195	COG0653	protein targeting
HRM2_RS13200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRM2_RS13210	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HRM2_RS13225	COG2358	TRAP transporter, solute receptor (TAXI family
HRM2_RS13240	COG0215	cysteine-tRNA ligase activity
HRM2_RS13245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRM2_RS13250	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRM2_RS13260	COG0776	regulation of translation
HRM2_RS13265	COG0470	DNA polymerase III
HRM2_RS13270	COG1774	PSP1 C-terminal conserved region
HRM2_RS13275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRM2_RS13275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRM2_RS13285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRM2_RS13290	COG0504	CTP synthase activity
HRM2_RS13295	COG0148	phosphopyruvate hydratase activity
HRM2_RS13305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRM2_RS13310	COG0189	ligase activity
HRM2_RS13330	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HRM2_RS13330	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HRM2_RS13335	COG1268	BioY protein
HRM2_RS13340	COG1122	ATPase activity
HRM2_RS13360	COG0196	riboflavin kinase activity
HRM2_RS13365	COG0242	peptide deformylase activity
HRM2_RS13370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRM2_RS13375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRM2_RS13375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRM2_RS13380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRM2_RS13385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HRM2_RS13395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HRM2_RS13395	COG0517	IMP dehydrogenase activity
HRM2_RS13395	COG0617	tRNA 3'-terminal CCA addition
HRM2_RS13410	COG0784	Response regulator, receiver
HRM2_RS13410	COG3437	response regulator, receiver
HRM2_RS13415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRM2_RS13425	COG0776	regulation of translation
HRM2_RS13455	COG0268	Binds directly to 16S ribosomal RNA
HRM2_RS13465	COG0495	leucyl-tRNA aminoacylation
HRM2_RS13470	COG1530	ribonuclease E activity
HRM2_RS13480	COG1862	Preprotein translocase
HRM2_RS13485	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRM2_RS13490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRM2_RS13500	COG0758	DNA mediated transformation
HRM2_RS13500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRM2_RS13505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRM2_RS13520	COG0488	(ABC) transporter
HRM2_RS13525	COG4239	(ABC) transporter, permease
HRM2_RS13530	COG4174	ABC transporter (Permease)
HRM2_RS13535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRM2_RS13540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRM2_RS13545	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HRM2_RS13555	COG2195	Cleaves the N-terminal amino acid of tripeptides
HRM2_RS13565	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HRM2_RS13580	COG1028	Short-chain dehydrogenase reductase Sdr
HRM2_RS13610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRM2_RS13615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRM2_RS13620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRM2_RS13630	COG0165	Argininosuccinate lyase
HRM2_RS13635	COG0137	argininosuccinate synthase activity
HRM2_RS13640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRM2_RS13645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRM2_RS13650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRM2_RS13655	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HRM2_RS13660	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HRM2_RS13665	COG4974	Belongs to the 'phage' integrase family
HRM2_RS13675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HRM2_RS13700	COG4966	pilus assembly protein PilW
HRM2_RS13720	COG1131	(ABC) transporter
HRM2_RS13745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRM2_RS13750	COG0540	Belongs to the ATCase OTCase family
HRM2_RS13770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HRM2_RS13775	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HRM2_RS13790	COG1137	ATPase activity
HRM2_RS13795	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HRM2_RS13800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRM2_RS13805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRM2_RS13810	COG1660	Displays ATPase and GTPase activities
HRM2_RS13815	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRM2_RS13825	COG0149	triose-phosphate isomerase activity
HRM2_RS13830	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRM2_RS13840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRM2_RS13845	COG0535	radical SAM domain protein
HRM2_RS13850	COG0113	porphobilinogen synthase activity
HRM2_RS13855	COG0535	radical SAM domain protein
HRM2_RS13860	COG0205	6-phosphofructokinase activity
HRM2_RS13870	COG0552	protein localization to endoplasmic reticulum
HRM2_RS13875	COG3141	response to X-ray
HRM2_RS13890	COG4585	Histidine kinase
HRM2_RS13905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRM2_RS13920	COG0751	glycine-tRNA ligase activity
HRM2_RS13925	COG0752	glycyl-tRNA synthetase alpha subunit
HRM2_RS13935	COG1381	Involved in DNA repair and RecF pathway recombination
HRM2_RS13940	COG2239	Acts as a magnesium transporter
HRM2_RS13965	COG1752	Esterase of the alpha-beta hydrolase superfamily
HRM2_RS13975	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HRM2_RS13985	COG2186	Transcriptional regulator
HRM2_RS13990	COG0247	lactate metabolic process
HRM2_RS13995	COG0277	FAD linked oxidase domain protein
HRM2_RS14000	COG1620	l-lactate permease
HRM2_RS14010	COG1139	Iron-sulfur cluster binding protein
HRM2_RS14020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRM2_RS14025	COG2816	NAD+ diphosphatase activity
HRM2_RS14030	COG0433	COG0433 Predicted ATPase
HRM2_RS14065	COG1115	amino acid carrier protein
HRM2_RS14070	COG0402	S-adenosylhomocysteine deaminase activity
HRM2_RS14090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRM2_RS14095	COG0573	inorganic phosphate transmembrane transporter activity
HRM2_RS14100	COG0581	inorganic phosphate transmembrane transporter activity
HRM2_RS14105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRM2_RS14115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRM2_RS14125	COG0484	heat shock protein binding
HRM2_RS14135	COG4608	Belongs to the ABC transporter superfamily
HRM2_RS14140	COG0444	Belongs to the ABC transporter superfamily
HRM2_RS14150	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HRM2_RS14155	COG1360	Flagellar Motor Protein
HRM2_RS14165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRM2_RS14185	COG1022	Amp-dependent synthetase and ligase
HRM2_RS14195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRM2_RS14245	COG0123	including yeast histone deacetylase and acetoin utilization protein
HRM2_RS14250	COG0517	IMP dehydrogenase activity
HRM2_RS14255	COG0443	Heat shock 70 kDa protein
HRM2_RS14265	COG2084	Dehydrogenase
HRM2_RS14275	COG1205	dead DEAH box helicase
HRM2_RS14275	COG1111	helicase
HRM2_RS14280	COG0010	Belongs to the arginase family
HRM2_RS14290	COG1234	tRNA 3'-trailer cleavage
HRM2_RS14295	COG0500	methyltransferase
HRM2_RS14300	COG4106	trans-aconitate 2-methyltransferase activity
HRM2_RS14305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HRM2_RS14335	COG0297	glycogen (starch) synthase activity
HRM2_RS14340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRM2_RS14345	COG1802	Transcriptional regulator
HRM2_RS14350	COG0028	Belongs to the TPP enzyme family
HRM2_RS14355	COG2358	TRAP transporter, solute receptor (TAXI family
HRM2_RS14360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRM2_RS14365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRM2_RS14400	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRM2_RS14445	COG2719	SpoVR family
HRM2_RS14475	COG1024	Enoyl-CoA hydratase
HRM2_RS14480	COG1028	Short-chain dehydrogenase reductase Sdr
HRM2_RS14490	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HRM2_RS14500	COG0719	Fe-S assembly protein
HRM2_RS14505	COG0396	ATPase activity
HRM2_RS14530	COG0358	DNA primase activity
HRM2_RS14535	COG0131	Imidazoleglycerol-phosphate dehydratase
HRM2_RS14540	COG4067	protein conserved in archaea
HRM2_RS14540	COG0189	ligase activity
HRM2_RS14545	COG0189	ligase activity
HRM2_RS14545	COG0569	domain protein
HRM2_RS14565	COG0167	dihydroorotate dehydrogenase activity
HRM2_RS14595	COG0714	Associated with various cellular activities
HRM2_RS14610	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HRM2_RS14630	COG1174	glycine betaine transport
HRM2_RS14645	COG1063	alcohol dehydrogenase
HRM2_RS14650	COG5002	protein histidine kinase activity
HRM2_RS14705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRM2_RS14710	COG0702	epimerase
HRM2_RS14720	COG1215	transferase activity, transferring glycosyl groups
HRM2_RS14735	COG1216	Glycosyl transferase, family 2
HRM2_RS14735	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS14745	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS14775	COG0463	Glycosyl transferase, family 2
HRM2_RS14815	COG1682	transport, permease protein
HRM2_RS14860	COG2204	response regulator
HRM2_RS14865	COG3852	Histidine kinase
HRM2_RS14875	COG1450	Type ii and iii secretion system protein
HRM2_RS14905	COG2165	general secretion pathway protein
HRM2_RS14930	COG2165	general secretion pathway protein
HRM2_RS14935	COG1459	type II secretion system
HRM2_RS14940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRM2_RS14945	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HRM2_RS14965	COG1362	aminopeptidase activity
HRM2_RS14975	COG1469	GTP cyclohydrolase I activity
HRM2_RS14980	COG0037	tRNA processing
HRM2_RS14985	COG1758	RNA polymerase activity
HRM2_RS14990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRM2_RS14995	COG0688	phosphatidylethanolamine metabolic process
HRM2_RS15000	COG1214	PFAM Peptidase M22, glycoprotease
HRM2_RS15005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRM2_RS15030	COG2925	Exonuclease
HRM2_RS15035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRM2_RS15040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRM2_RS15060	COG2255	four-way junction helicase activity
HRM2_RS15065	COG0632	four-way junction helicase activity
HRM2_RS15070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HRM2_RS15080	COG2885	chlorophyll binding
HRM2_RS15085	COG0823	Involved in the tonB-independent uptake of proteins
HRM2_RS15095	COG0848	biopolymer transport protein
HRM2_RS15105	COG0459	protein refolding
HRM2_RS15110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRM2_RS15125	COG0330	HflC and HflK could
HRM2_RS15155	COG1528	Iron-storage protein
HRM2_RS15170	COG0277	FAD linked oxidase domain protein
HRM2_RS15180	COG3875	lactate racemase activity
HRM2_RS15210	COG0745	RESPONSE REGULATOR receiver
HRM2_RS15220	COG5002	protein histidine kinase activity
HRM2_RS15225	COG4786	Flagellar basal body rod
HRM2_RS15260	COG3852	Histidine kinase
HRM2_RS15270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRM2_RS15275	COG0792	nuclease activity
HRM2_RS15280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRM2_RS15285	COG0335	large ribosomal subunit rRNA binding
HRM2_RS15290	COG4752	Belongs to the RNA methyltransferase TrmD family
HRM2_RS15295	COG0336	Belongs to the RNA methyltransferase TrmD family
HRM2_RS15300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRM2_RS15305	COG1837	Belongs to the UPF0109 family
HRM2_RS15310	COG0228	four-way junction DNA binding
HRM2_RS15315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HRM2_RS15320	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HRM2_RS15325	COG0482	sulfurtransferase activity
HRM2_RS15335	COG0745	RESPONSE REGULATOR receiver
HRM2_RS15340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRM2_RS15345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HRM2_RS15370	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS15385	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HRM2_RS15390	COG1342	Belongs to the UPF0251 family
HRM2_RS15395	COG2046	Belongs to the sulfate adenylyltransferase family
HRM2_RS15415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRM2_RS15420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRM2_RS15425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HRM2_RS15430	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRM2_RS15430	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRM2_RS15435	COG0307	riboflavin synthase, alpha
HRM2_RS15440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRM2_RS15440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRM2_RS15445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRM2_RS15455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRM2_RS15460	COG0698	ribose 5-phosphate isomerase
HRM2_RS15465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRM2_RS15470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRM2_RS15475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRM2_RS15490	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRM2_RS15495	COG0375	protein maturation
HRM2_RS15500	COG0436	Aminotransferase
HRM2_RS15505	COG0343	queuine tRNA-ribosyltransferase activity
HRM2_RS15520	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRM2_RS15555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HRM2_RS15565	COG0154	amidase activity
HRM2_RS15570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRM2_RS15580	COG0018	arginyl-trna synthetase
HRM2_RS15605	COG0166	Belongs to the GPI family
HRM2_RS15610	COG1362	aminopeptidase activity
HRM2_RS15650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HRM2_RS15655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRM2_RS15660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRM2_RS15665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRM2_RS15670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRM2_RS15675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRM2_RS15680	COG0799	negative regulation of ribosome biogenesis
HRM2_RS15685	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HRM2_RS15700	COG5016	pyruvate
HRM2_RS15700	COG0511	ligase activity, forming carbon-carbon bonds
HRM2_RS15710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRM2_RS15715	COG0237	dephospho-CoA kinase activity
HRM2_RS15725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRM2_RS15735	COG1192	Involved in chromosome partitioning
HRM2_RS15740	COG1475	DNA binding
HRM2_RS15755	COG0204	Acyl-transferase
HRM2_RS15780	COG1335	isochorismatase
HRM2_RS15785	COG0745	RESPONSE REGULATOR receiver
HRM2_RS15790	COG5002	protein histidine kinase activity
HRM2_RS15795	COG0745	RESPONSE REGULATOR receiver
HRM2_RS15835	COG4658	electron transport chain
HRM2_RS15840	COG4659	FMN binding
HRM2_RS15845	COG4660	Part of a membrane complex involved in electron transport
HRM2_RS15850	COG4657	Part of a membrane complex involved in electron transport
HRM2_RS15865	COG1477	protein flavinylation
HRM2_RS15870	COG1242	4 iron, 4 sulfur cluster binding
HRM2_RS15875	COG0445	tRNA wobble uridine modification
HRM2_RS15900	COG2267	carboxylic ester hydrolase activity
HRM2_RS15925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRM2_RS15935	COG0477	Major facilitator Superfamily
HRM2_RS15950	COG1342	Belongs to the UPF0251 family
HRM2_RS15960	COG1793	dna ligase
HRM2_RS15965	COG3875	lactate racemase activity
HRM2_RS15970	COG0067	glutamate synthase
HRM2_RS15970	COG0070	glutamate synthase
HRM2_RS15970	COG0069	glutamate synthase activity
HRM2_RS15975	COG0493	'glutamate synthase
HRM2_RS15985	COG0837	glucose binding
HRM2_RS15990	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HRM2_RS15990	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HRM2_RS15995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRM2_RS16000	COG1053	succinate dehydrogenase
HRM2_RS16010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HRM2_RS16015	COG0045	succinate-CoA ligase (ADP-forming) activity
HRM2_RS16020	COG1703	isobutyryl-CoA mutase activity
HRM2_RS16025	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRM2_RS16025	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRM2_RS16030	COG0346	lactoylglutathione lyase activity
HRM2_RS16035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HRM2_RS16040	COG0513	Belongs to the DEAD box helicase family
HRM2_RS16050	COG2815	serine threonine protein kinase
HRM2_RS16050	COG0515	serine threonine protein kinase
HRM2_RS16065	COG3842	ATPase activity
HRM2_RS16070	COG4149	molybdate abc transporter
HRM2_RS16075	COG0725	ABC transporter, periplasmic molybdate-binding protein
HRM2_RS16100	COG1131	(ABC) transporter
HRM2_RS16155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRM2_RS16165	COG0778	Nitroreductase
HRM2_RS16175	COG1295	ribonuclease BN
HRM2_RS16180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRM2_RS16205	COG0513	Belongs to the DEAD box helicase family
HRM2_RS16215	COG3360	Dodecin
HRM2_RS16255	COG1278	Cold shock
HRM2_RS16285	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRM2_RS16295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HRM2_RS16305	COG1674	ftsk spoiiie
HRM2_RS16310	COG0557	exoribonuclease II activity
HRM2_RS16315	COG0138	bifunctional purine biosynthesis protein purh
HRM2_RS16320	COG0138	bifunctional purine biosynthesis protein purh
HRM2_RS16330	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HRM2_RS16335	COG0456	acetyltransferase
HRM2_RS16340	COG2186	Transcriptional regulator
HRM2_RS16345	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HRM2_RS16350	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HRM2_RS16360	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HRM2_RS16365	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HRM2_RS16380	COG1192	Involved in chromosome partitioning
HRM2_RS16400	COG4974	Belongs to the 'phage' integrase family
HRM2_RS16405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HRM2_RS16405	COG2070	2-Nitropropane dioxygenase
HRM2_RS16450	COG3028	Belongs to the UPF0307 family
HRM2_RS16455	COG1032	radical SAM domain protein
HRM2_RS16465	COG0668	transmembrane transport
HRM2_RS16470	COG1132	(ABC) transporter
HRM2_RS16475	COG1132	(ABC) transporter
HRM2_RS16490	COG0784	Response regulator, receiver
HRM2_RS16500	COG0159	tryptophan synthase activity
HRM2_RS16505	COG0133	tryptophan synthase activity
HRM2_RS16510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRM2_RS16520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRM2_RS16530	COG0659	secondary active sulfate transmembrane transporter activity
HRM2_RS16550	COG1121	(ABC) transporter
HRM2_RS16555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRM2_RS16575	COG0243	molybdopterin cofactor binding
HRM2_RS16600	COG0437	4 iron, 4 sulfur cluster binding
HRM2_RS16605	COG0500	methyltransferase
HRM2_RS16630	COG1131	(ABC) transporter
HRM2_RS16640	COG4974	Belongs to the 'phage' integrase family
HRM2_RS16645	COG3189	MarR family transcriptional regulator
HRM2_RS16680	COG0411	ABC transporter
HRM2_RS16690	COG0683	leucine binding
HRM2_RS16730	COG1278	Cold shock
HRM2_RS16740	COG2814	Major facilitator Superfamily
HRM2_RS16755	COG0653	protein targeting
HRM2_RS16765	COG1272	protein, Hemolysin III
HRM2_RS16800	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HRM2_RS16810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRM2_RS16845	COG1335	isochorismatase
HRM2_RS16855	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRM2_RS16865	COG1121	(ABC) transporter
HRM2_RS16870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRM2_RS16875	COG1053	succinate dehydrogenase
HRM2_RS16880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRM2_RS16890	COG0463	Glycosyl transferase, family 2
HRM2_RS16915	COG4974	Belongs to the 'phage' integrase family
HRM2_RS16945	COG5012	cobalamin binding
HRM2_RS16980	COG0835	chemotaxis
HRM2_RS17000	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HRM2_RS17010	COG0745	RESPONSE REGULATOR receiver
HRM2_RS17020	COG2201	protein-glutamate methylesterase activity
HRM2_RS17030	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HRM2_RS17035	COG0745	RESPONSE REGULATOR receiver
HRM2_RS17040	COG2204	response regulator
HRM2_RS17055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HRM2_RS17075	COG0505	Belongs to the CarA family
HRM2_RS17120	COG3604	Transcriptional regulator
HRM2_RS17190	COG0709	Synthesizes selenophosphate from selenide and ATP
HRM2_RS17200	COG1104	cysteine desulfurase activity
HRM2_RS17245	COG3842	ATPase activity
HRM2_RS17255	COG1177	transmembrane transport
HRM2_RS17275	COG0730	response to heat
HRM2_RS17290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRM2_RS17335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRM2_RS17355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRM2_RS17360	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRM2_RS17365	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRM2_RS17370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRM2_RS17375	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRM2_RS17380	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRM2_RS17385	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRM2_RS17395	COG0772	Belongs to the SEDS family
HRM2_RS17400	COG0768	penicillin binding
HRM2_RS17415	COG1077	Cell shape determining protein MreB Mrl
HRM2_RS17420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HRM2_RS17425	COG1619	proteins homologs of microcin C7 resistance protein MccF
HRM2_RS17435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HRM2_RS17450	COG0651	ATP synthesis coupled electron transport
HRM2_RS17460	COG0651	ATP synthesis coupled electron transport
HRM2_RS17465	COG0651	ATP synthesis coupled electron transport
HRM2_RS17470	COG1006	Multisubunit Na H antiporter MnhC subunit
HRM2_RS17475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRM2_RS17475	COG2111	Na H antiporter
HRM2_RS17500	COG0826	peptidase U32
HRM2_RS17525	COG0488	(ABC) transporter
HRM2_RS17535	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HRM2_RS17540	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HRM2_RS17545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRM2_RS17550	COG0277	FAD linked oxidase domain protein
HRM2_RS17560	COG0457	Tetratricopeptide repeat
HRM2_RS17585	COG1100	Small GTP-binding protein
HRM2_RS17610	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HRM2_RS17620	COG0247	lactate metabolic process
HRM2_RS17620	COG2181	nitrate reductase activity
HRM2_RS17625	COG1309	transcriptional regulator
HRM2_RS17650	COG0107	imidazoleglycerol-phosphate synthase activity
HRM2_RS17655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRM2_RS17660	COG3956	TIGRFAM MazG family protein
HRM2_RS17675	COG1480	7TM receptor with intracellular HD hydrolase
HRM2_RS17680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRM2_RS17685	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HRM2_RS17690	COG0564	pseudouridine synthase activity
HRM2_RS17700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRM2_RS17700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRM2_RS17705	COG3012	SEC-C Motif Domain Protein
HRM2_RS17710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRM2_RS17710	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRM2_RS17715	COG0802	atpase or kinase
HRM2_RS17720	COG0527	aspartate kinase activity
HRM2_RS17725	COG0284	orotidine-5'-phosphate decarboxylase activity
HRM2_RS17730	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HRM2_RS17735	COG1921	L-seryl-tRNASec selenium transferase activity
HRM2_RS17745	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HRM2_RS17755	COG0181	hydroxymethylbilane synthase activity
HRM2_RS17760	COG1587	Uroporphyrinogen-III synthase
HRM2_RS17760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRM2_RS17765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRM2_RS17775	COG0203	ribosomal protein L17
HRM2_RS17780	COG0202	RNA polymerase activity
HRM2_RS17785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRM2_RS17790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRM2_RS17795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRM2_RS17800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRM2_RS17810	COG0200	Binds to the 23S rRNA
HRM2_RS17815	COG1841	ribosomal large subunit assembly
HRM2_RS17825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRM2_RS17830	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRM2_RS17835	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HRM2_RS17840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRM2_RS17845	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HRM2_RS17850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRM2_RS17855	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRM2_RS17860	COG0255	Belongs to the universal ribosomal protein uL29 family
HRM2_RS17865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRM2_RS17870	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRM2_RS17875	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRM2_RS17880	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRM2_RS17885	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRM2_RS17890	COG0089	rRNA binding
HRM2_RS17895	COG0088	Forms part of the polypeptide exit tunnel
HRM2_RS17900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRM2_RS17905	COG0051	transcription antitermination factor activity, RNA binding
HRM2_RS17910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRM2_RS17915	COG0049	tRNA binding
HRM2_RS17920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRM2_RS17925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRM2_RS17930	COG0085	RNA polymerase activity
HRM2_RS17935	COG0222	ribosome binding
HRM2_RS17940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRM2_RS17945	COG0081	regulation of translation
HRM2_RS17950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRM2_RS17970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRM2_RS17995	COG1388	LysM domain
HRM2_RS17995	COG0741	lytic transglycosylase activity
HRM2_RS18005	COG0826	peptidase U32
HRM2_RS18010	COG0643	Histidine kinase
HRM2_RS18010	COG2198	Histidine kinase
HRM2_RS18015	COG0835	chemotaxis
HRM2_RS18020	COG2201	protein-glutamate methylesterase activity
HRM2_RS18025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HRM2_RS18030	COG0745	RESPONSE REGULATOR receiver
HRM2_RS18040	COG0126	phosphoglycerate kinase activity
HRM2_RS18050	COG2003	Belongs to the UPF0758 family
HRM2_RS18060	COG0628	permease
HRM2_RS18065	COG0183	Belongs to the thiolase family
HRM2_RS18075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRM2_RS18080	COG1160	GTP binding
HRM2_RS18100	COG0569	domain protein
HRM2_RS18115	COG1086	Polysaccharide biosynthesis protein
HRM2_RS18120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRM2_RS18130	COG2089	acid synthase
HRM2_RS18155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRM2_RS18175	COG0107	imidazoleglycerol-phosphate synthase activity
HRM2_RS18180	COG1083	cytidylyl-transferase
HRM2_RS18190	COG2604	Protein of unknown function DUF115
HRM2_RS18195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRM2_RS18195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRM2_RS18220	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HRM2_RS18225	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HRM2_RS18250	COG1706	bacterial-type flagellum-dependent cell motility
HRM2_RS18255	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HRM2_RS18315	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRM2_RS18320	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRM2_RS18325	COG1684	flagellar biosynthetic protein fliR
HRM2_RS18330	COG1987	bacterial-type flagellum assembly
HRM2_RS18335	COG1338	Plays a role in the flagellum-specific transport system
HRM2_RS18360	COG1749	Flagellar hook protein flgE
HRM2_RS18360	COG1749	Flagellar hook protein flgE
HRM2_RS18395	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRM2_RS18400	COG1766	The M ring may be actively involved in energy transduction
HRM2_RS18405	COG1677	Flagellar hook-basal body complex protein FliE
HRM2_RS18415	COG1815	bacterial-type flagellum-dependent cell motility
HRM2_RS18420	COG2204	response regulator
HRM2_RS18450	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HRM2_RS18450	COG2199	diguanylate cyclase activity
HRM2_RS18455	COG1522	sequence-specific DNA binding
HRM2_RS18465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRM2_RS18465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRM2_RS18475	COG1234	tRNA 3'-trailer cleavage
HRM2_RS18485	COG2814	Major facilitator Superfamily
HRM2_RS18490	COG1032	radical SAM domain protein
HRM2_RS18500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRM2_RS18520	COG0076	glutamate decarboxylase activity
HRM2_RS18535	COG1013	pyruvate-flavodoxin oxidoreductase activity
HRM2_RS18540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRM2_RS18540	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRM2_RS18550	COG1216	Glycosyl transferase, family 2
HRM2_RS18565	COG1643	Atp-dependent helicase
HRM2_RS18585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRM2_RS18590	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRM2_RS18595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRM2_RS18625	COG0840	transmembrane signaling receptor activity
HRM2_RS18640	COG4120	Belongs to the binding-protein-dependent transport system permease family
HRM2_RS18645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRM2_RS18650	COG1217	gtp-binding protein TYPA
HRM2_RS18665	COG0045	succinate-CoA ligase (ADP-forming) activity
HRM2_RS18665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRM2_RS18665	COG1042	CoA-binding domain protein
HRM2_RS18670	COG2204	response regulator
HRM2_RS18705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRM2_RS18710	COG0534	Mate efflux family protein
HRM2_RS18725	COG2172	sigma factor antagonist activity
HRM2_RS18755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HRM2_RS18770	COG0205	6-phosphofructokinase activity
HRM2_RS18780	COG1846	Transcriptional regulator
HRM2_RS18790	COG4176	ABC-type proline glycine betaine transport system permease component
HRM2_RS18795	COG4175	Glycine betaine
HRM2_RS18795	COG0517	IMP dehydrogenase activity
HRM2_RS18805	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HRM2_RS18815	COG2204	response regulator
HRM2_RS18835	COG2204	response regulator
HRM2_RS18840	COG0745	RESPONSE REGULATOR receiver
HRM2_RS18850	COG2204	response regulator
HRM2_RS18855	COG4191	Histidine kinase
HRM2_RS18865	COG2204	response regulator
HRM2_RS18880	COG2204	response regulator
HRM2_RS18885	COG0471	metal ion transport
HRM2_RS18895	COG2204	response regulator
HRM2_RS18905	COG0589	response to stress
HRM2_RS18910	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS18940	COG0583	DNA-binding transcription factor activity
HRM2_RS18945	COG0655	NAD(P)H dehydrogenase (quinone) activity
HRM2_RS18955	COG0537	adenosine 5'-monophosphoramidase activity
HRM2_RS18960	COG0598	Magnesium transport protein CorA
HRM2_RS18965	COG2086	electron transfer activity
HRM2_RS18980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRM2_RS18995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRM2_RS19005	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HRM2_RS19020	COG0028	Belongs to the TPP enzyme family
HRM2_RS19025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRM2_RS19025	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRM2_RS19030	COG1802	Transcriptional regulator
HRM2_RS19040	COG1012	belongs to the aldehyde dehydrogenase family
HRM2_RS19060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRM2_RS19070	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HRM2_RS19080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HRM2_RS19085	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HRM2_RS19105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRM2_RS19125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HRM2_RS19150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRM2_RS19155	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRM2_RS19160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRM2_RS19170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRM2_RS19195	COG1024	Enoyl-CoA hydratase
HRM2_RS19220	COG0651	ATP synthesis coupled electron transport
HRM2_RS19235	COG0651	ATP synthesis coupled electron transport
HRM2_RS19240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRM2_RS19240	COG0649	NAD binding
HRM2_RS19245	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRM2_RS19250	COG0513	Belongs to the DEAD box helicase family
HRM2_RS19255	COG0513	Belongs to the DEAD box helicase family
HRM2_RS19280	COG0450	alkyl hydroperoxide reductase
HRM2_RS19295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HRM2_RS19300	COG4134	Bacterial extracellular solute-binding protein
HRM2_RS19330	COG1136	(ABC) transporter
HRM2_RS19330	COG0577	efflux transmembrane transporter activity
HRM2_RS19390	COG0101	tRNA pseudouridine synthase activity
HRM2_RS19425	COG4251	negative regulation of phosphorylation
HRM2_RS19425	COG3706	GGDEF domain
HRM2_RS19425	COG2203	Gaf domain
HRM2_RS19425	COG5001	Diguanylate cyclase
HRM2_RS19475	COG2433	Pfam Transposase IS66
HRM2_RS19495	COG3436	PFAM IS66 Orf2 family protein
HRM2_RS19510	COG1846	Transcriptional regulator
HRM2_RS19550	COG0675	Transposase, IS605 OrfB family
HRM2_RS19560	COG1061	Type III restriction enzyme res subunit
HRM2_RS19615	COG3615	Tellurite resistance protein tehB
HRM2_RS19615	COG0500	methyltransferase
HRM2_RS19670	COG4221	oxidoreductase activity
HRM2_RS19685	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS19715	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS19740	COG1058	Belongs to the CinA family
HRM2_RS19740	COG1546	Belongs to the CinA family
HRM2_RS19745	COG3852	Histidine kinase
HRM2_RS19750	COG2204	response regulator
HRM2_RS19755	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS19805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRM2_RS19810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRM2_RS19825	COG0589	response to stress
HRM2_RS19835	COG0517	IMP dehydrogenase activity
HRM2_RS19840	COG2204	response regulator
HRM2_RS19845	COG4191	Histidine kinase
HRM2_RS19875	COG2204	response regulator
HRM2_RS19890	COG4191	Histidine kinase
HRM2_RS19900	COG0659	secondary active sulfate transmembrane transporter activity
HRM2_RS19910	COG2204	response regulator
HRM2_RS19920	COG0564	pseudouridine synthase activity
HRM2_RS19925	COG0390	transport system, permease component
HRM2_RS19930	COG4619	ABC transporter
HRM2_RS19940	COG1971	Probably functions as a manganese efflux pump
HRM2_RS19945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRM2_RS19960	COG2996	Protein conserved in bacteria
HRM2_RS19970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRM2_RS19995	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HRM2_RS19995	COG2199	diguanylate cyclase activity
HRM2_RS20000	COG3706	GGDEF domain
HRM2_RS20005	COG0210	DNA helicase
HRM2_RS20015	COG1968	undecaprenyl-diphosphatase activity
HRM2_RS20020	COG1151	hydroxylamine reductase activity
HRM2_RS20040	COG2379	hydroxypyruvate reductase
HRM2_RS20045	COG1489	DNA binding
HRM2_RS20055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRM2_RS20080	COG1271	oxidase subunit
HRM2_RS20085	COG1294	oxidase, subunit
HRM2_RS20135	COG1090	epimerase
HRM2_RS20140	COG0765	amino acid transport
HRM2_RS20145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRM2_RS20150	COG0765	amino acid transport
HRM2_RS20160	COG4991	sh3 domain protein
HRM2_RS20160	COG3103	Sh3 type 3 domain protein
HRM2_RS20160	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRM2_RS20165	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRM2_RS20190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRM2_RS20220	COG0708	Exodeoxyribonuclease III
HRM2_RS20245	COG0538	isocitrate dehydrogenase activity
HRM2_RS20255	COG0372	Belongs to the citrate synthase family
HRM2_RS20285	COG1013	pyruvate-flavodoxin oxidoreductase activity
HRM2_RS20300	COG1104	cysteine desulfurase activity
HRM2_RS20305	COG0697	spore germination
HRM2_RS20310	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HRM2_RS20325	COG1132	(ABC) transporter
HRM2_RS20325	COG1132	(ABC) transporter
HRM2_RS20340	COG1366	Belongs to the anti-sigma-factor antagonist family
HRM2_RS20385	COG0530	calcium, potassium:sodium antiporter activity
HRM2_RS20390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HRM2_RS20410	COG1349	DNA-binding transcription factor activity
HRM2_RS20415	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HRM2_RS20435	COG4191	Histidine kinase
HRM2_RS20445	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HRM2_RS20470	COG1136	(ABC) transporter
HRM2_RS20475	COG0577	efflux transmembrane transporter activity
HRM2_RS20480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRM2_RS20500	COG1132	(ABC) transporter
HRM2_RS20500	COG1132	(ABC) transporter
HRM2_RS20505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRM2_RS20520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRM2_RS20525	COG1024	Enoyl-CoA hydratase
HRM2_RS20555	COG0406	alpha-ribazole phosphatase activity
HRM2_RS20560	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS20580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRM2_RS20585	COG1120	ATPase activity
HRM2_RS20595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRM2_RS20615	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS20625	COG4191	Histidine kinase
HRM2_RS20635	COG3022	response to hydroperoxide
HRM2_RS20640	COG0745	RESPONSE REGULATOR receiver
HRM2_RS20645	COG4191	Histidine kinase
HRM2_RS20650	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HRM2_RS20665	COG5001	Diguanylate cyclase
HRM2_RS20665	COG3300	MHYT domain
HRM2_RS20690	COG1773	rubredoxin
HRM2_RS20700	COG2033	superoxide reductase activity
HRM2_RS20705	COG1592	Rubrerythrin
HRM2_RS20715	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HRM2_RS20745	COG3243	poly(R)-hydroxyalkanoic acid synthase
HRM2_RS20755	COG2030	dehydratase
HRM2_RS20785	COG1842	Phage shock protein A
HRM2_RS20790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HRM2_RS20795	COG0785	Cytochrome C biogenesis protein
HRM2_RS20820	COG3830	Belongs to the UPF0237 family
HRM2_RS20820	COG0560	Phosphoserine phosphatase
HRM2_RS20825	COG1378	Sugar-specific transcriptional regulator TrmB
HRM2_RS20840	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HRM2_RS20845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRM2_RS20855	COG0513	Belongs to the DEAD box helicase family
HRM2_RS20860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRM2_RS20865	COG0805	protein transport
HRM2_RS20875	COG1797	cobyrinic acid a,c-diamide synthase activity
HRM2_RS20885	COG2221	Nitrite and sulphite reductase 4Fe-4S
HRM2_RS20890	COG2221	Nitrite and sulphite reductase 4Fe-4S
HRM2_RS20905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRM2_RS20965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRM2_RS20970	COG0741	lytic transglycosylase activity
HRM2_RS21005	COG1993	acr, cog1993
HRM2_RS21010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRM2_RS21035	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HRM2_RS21055	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HRM2_RS21055	COG1918	ferrous iron import across plasma membrane
HRM2_RS21085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRM2_RS21085	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRM2_RS21105	COG0288	reversible hydration of carbon dioxide
HRM2_RS21115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRM2_RS21125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRM2_RS21125	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRM2_RS21140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRM2_RS21145	COG0745	RESPONSE REGULATOR receiver
HRM2_RS21150	COG2205	protein histidine kinase activity
HRM2_RS21165	COG3267	Type II secretory pathway component ExeA
HRM2_RS21165	COG3409	Peptidoglycan-binding domain 1 protein
HRM2_RS21180	COG0577	efflux transmembrane transporter activity
HRM2_RS21190	COG0574	Belongs to the PEP-utilizing enzyme family
HRM2_RS21190	COG3848	Pyruvate phosphate dikinase
HRM2_RS21225	COG0824	Thioesterase
HRM2_RS21240	COG2031	fatty acid transporter
HRM2_RS21250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRM2_RS21255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRM2_RS21295	COG1739	Uncharacterized protein family UPF0029
HRM2_RS21330	COG2205	protein histidine kinase activity
HRM2_RS21330	COG0784	Response regulator, receiver
HRM2_RS21330	COG5002	protein histidine kinase activity
HRM2_RS21365	COG4717	serine-type aminopeptidase activity
HRM2_RS21370	COG0420	3'-5' exonuclease activity
HRM2_RS21385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRM2_RS21405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRM2_RS21410	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRM2_RS21415	COG1151	hydroxylamine reductase activity
HRM2_RS21425	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HRM2_RS21435	COG0490	domain, Protein
HRM2_RS21435	COG0471	metal ion transport
HRM2_RS21445	COG0066	3-isopropylmalate dehydratase activity
HRM2_RS21450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRM2_RS21455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRM2_RS21460	COG2172	sigma factor antagonist activity
HRM2_RS21465	COG1366	Belongs to the anti-sigma-factor antagonist family
HRM2_RS21470	COG0058	SHG alpha-glucan phosphorylase activity
HRM2_RS21475	COG0784	Response regulator, receiver
HRM2_RS21475	COG2205	protein histidine kinase activity
HRM2_RS21475	COG5002	protein histidine kinase activity
HRM2_RS21500	COG0427	acetyl-CoA hydrolase
HRM2_RS21515	COG0840	transmembrane signaling receptor activity
HRM2_RS21530	COG0765	amino acid transport
HRM2_RS21535	COG0765	amino acid transport
HRM2_RS21540	COG1126	abc transporter atp-binding protein
HRM2_RS21550	COG2433	Pfam Transposase IS66
HRM2_RS21555	COG3436	PFAM IS66 Orf2 family protein
HRM2_RS21590	COG2161	toxin-antitoxin pair type II binding
HRM2_RS21610	COG1704	LemA family
HRM2_RS21625	COG0840	transmembrane signaling receptor activity
HRM2_RS21630	COG2133	pyrroloquinoline quinone binding
HRM2_RS21645	COG0646	methionine synthase
HRM2_RS21645	COG1410	methionine synthase
HRM2_RS21675	COG4651	solute:proton antiporter activity
HRM2_RS21675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRM2_RS21680	COG0646	methionine synthase
HRM2_RS21680	COG1410	methionine synthase
HRM2_RS21735	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HRM2_RS21740	COG2414	aldehyde ferredoxin oxidoreductase
HRM2_RS21750	COG2188	Transcriptional regulator
HRM2_RS21755	COG2986	histidine ammonia-lyase
HRM2_RS21765	COG0601	transmembrane transport
HRM2_RS21775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRM2_RS21795	COG5598	trimethylamine methyltransferase
HRM2_RS21820	COG0546	phosphoglycolate phosphatase activity
HRM2_RS21890	COG4974	Belongs to the 'phage' integrase family
HRM2_RS21950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRM2_RS21965	COG3550	peptidyl-serine autophosphorylation
HRM2_RS21980	COG3436	PFAM IS66 Orf2 family protein
HRM2_RS22005	COG3436	PFAM IS66 Orf2 family protein
HRM2_RS22025	COG2433	Pfam Transposase IS66
HRM2_RS22105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRM2_RS22110	COG0644	oxidoreductase
HRM2_RS22120	COG0456	acetyltransferase
HRM2_RS22125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRM2_RS22140	COG3133	Outer membrane lipoprotein
HRM2_RS22145	COG3437	response regulator, receiver
HRM2_RS22150	COG2084	Dehydrogenase
HRM2_RS22155	COG0733	neurotransmitter:sodium symporter activity
HRM2_RS22180	COG0247	lactate metabolic process
HRM2_RS22210	COG0688	phosphatidylethanolamine metabolic process
HRM2_RS22230	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HRM2_RS22240	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HRM2_RS22265	COG4771	TonB-dependent receptor
HRM2_RS22275	COG4771	TonB-dependent receptor
HRM2_RS22285	COG4771	TonB-dependent receptor
HRM2_RS22300	COG0798	PFAM Bile acid sodium symporter
HRM2_RS22305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRM2_RS22310	COG0640	Transcriptional regulator
HRM2_RS22315	COG5001	Diguanylate cyclase
HRM2_RS22315	COG4251	negative regulation of phosphorylation
HRM2_RS22315	COG2203	Gaf domain
HRM2_RS22315	COG3706	GGDEF domain
HRM2_RS22325	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS22335	COG0183	Belongs to the thiolase family
HRM2_RS22345	COG3290	protein histidine kinase activity
HRM2_RS22345	COG3829	transcription factor binding
HRM2_RS22360	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HRM2_RS22365	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HRM2_RS22370	COG2205	protein histidine kinase activity
HRM2_RS22375	COG0745	RESPONSE REGULATOR receiver
HRM2_RS22390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRM2_RS22400	COG1177	transmembrane transport
HRM2_RS22410	COG3842	ATPase activity
HRM2_RS22415	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HRM2_RS22420	COG0747	negative chemotaxis
HRM2_RS22425	COG0601	transmembrane transport
HRM2_RS22430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRM2_RS22435	COG0444	Belongs to the ABC transporter superfamily
HRM2_RS22440	COG4608	Belongs to the ABC transporter superfamily
HRM2_RS22470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRM2_RS22485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRM2_RS22485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRM2_RS22495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRM2_RS22500	COG0004	ammonium transporteR
HRM2_RS22510	COG0488	(ABC) transporter
HRM2_RS22520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HRM2_RS22525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRM2_RS22530	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HRM2_RS22540	COG0731	radical SAM domain protein
HRM2_RS22540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRM2_RS22570	COG2954	triphosphatase activity
HRM2_RS22585	COG1611	Belongs to the LOG family
HRM2_RS22590	COG4822	anaerobic cobalamin biosynthetic process
HRM2_RS22605	COG2204	response regulator
HRM2_RS22610	COG4191	Histidine kinase
HRM2_RS22620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRM2_RS22625	COG0482	sulfurtransferase activity
HRM2_RS22640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRM2_RS22695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HRM2_RS22700	COG5598	trimethylamine methyltransferase
HRM2_RS22710	COG2204	response regulator
HRM2_RS22715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRM2_RS22720	COG5012	cobalamin binding
HRM2_RS22730	COG0574	Belongs to the PEP-utilizing enzyme family
HRM2_RS22730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRM2_RS22765	COG0686	Belongs to the AlaDH PNT family
HRM2_RS22775	COG1131	(ABC) transporter
HRM2_RS22780	COG0613	PHP domain protein
HRM2_RS22825	COG0528	UMP kinase activity
HRM2_RS22835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HRM2_RS22845	COG0402	S-adenosylhomocysteine deaminase activity
HRM2_RS22855	COG4603	Belongs to the binding-protein-dependent transport system permease family
HRM2_RS22860	COG3845	ABC transporter
HRM2_RS22865	COG1744	ABC transporter substrate-binding protein PnrA-like
HRM2_RS22875	COG4895	conserved protein (DUF2196)
HRM2_RS22880	COG4681	YaeQ
HRM2_RS22925	COG2900	Belongs to the SlyX family
HRM2_RS22935	COG1126	abc transporter atp-binding protein
HRM2_RS22940	COG0765	amino acid transport
HRM2_RS22945	COG4597	amino acid ABC transporter
HRM2_RS22950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRM2_RS22960	COG0004	ammonium transporteR
HRM2_RS22965	COG2770	Histidine kinase
HRM2_RS22965	COG3437	response regulator, receiver
HRM2_RS22985	COG2813	Specifically methylates the guanine in position
HRM2_RS22985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HRM2_RS22990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HRM2_RS22995	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HRM2_RS23000	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HRM2_RS23005	COG1984	allophanate hydrolase subunit 2
HRM2_RS23030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRM2_RS23045	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRM2_RS23110	COG2081	HI0933 family
HRM2_RS23120	COG0509	glycine decarboxylation via glycine cleavage system
HRM2_RS23145	COG2204	response regulator
HRM2_RS23150	COG4191	Histidine kinase
HRM2_RS23215	COG0247	lactate metabolic process
HRM2_RS23215	COG2181	nitrate reductase activity
HRM2_RS23230	COG1802	Transcriptional regulator
HRM2_RS23275	COG0006	proline dipeptidase activity
HRM2_RS23280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRM2_RS23320	COG0437	4 iron, 4 sulfur cluster binding
HRM2_RS23330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRM2_RS23335	COG0514	ATP-dependent DNA helicase (RecQ)
HRM2_RS23350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRM2_RS23355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRM2_RS23360	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HRM2_RS23385	COG1122	ATPase activity
HRM2_RS23395	COG2824	Alkylphosphonate utilization operon protein PhnA
HRM2_RS23410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRM2_RS23415	COG1120	ATPase activity
HRM2_RS23440	COG3153	acetyltransferase
HRM2_RS23440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRM2_RS23455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRM2_RS23460	COG1566	PFAM secretion protein HlyD family protein
HRM2_RS23480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRM2_RS23485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRM2_RS23490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRM2_RS23540	COG3199	ATP-NAD kinase
HRM2_RS23545	COG0022	dehydrogenase e1 component
HRM2_RS23550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HRM2_RS23560	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRM2_RS23575	COG1028	Short-chain dehydrogenase reductase Sdr
HRM2_RS23595	COG2816	NAD+ diphosphatase activity
HRM2_RS23600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRM2_RS23620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRM2_RS23625	COG0505	Belongs to the CarA family
HRM2_RS23630	COG0493	'glutamate synthase
HRM2_RS23645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HRM2_RS23650	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS23655	COG0318	PFAM AMP-dependent synthetase and ligase
HRM2_RS23660	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HRM2_RS23670	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HRM2_RS23675	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRM2_RS23705	COG2985	domain, Protein
HRM2_RS23705	COG0569	domain protein
HRM2_RS23775	COG0582	viral genome integration into host DNA
HRM2_RS23790	COG0142	geranyltranstransferase activity
HRM2_RS23795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRM2_RS23825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRM2_RS23830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRM2_RS23830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRM2_RS23835	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRM2_RS23835	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRM2_RS23865	COG0701	Predicted permease
HRM2_RS23910	COG3040	lipid binding
HRM2_RS23915	COG1950	PFAM Membrane protein of
HRM2_RS23930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRM2_RS23935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRM2_RS23940	COG1045	serine acetyltransferase
HRM2_RS23950	COG1024	Enoyl-CoA hydratase
HRM2_RS23950	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRM2_RS23955	COG0183	Belongs to the thiolase family
HRM2_RS23965	COG2116	formate transmembrane transporter activity
HRM2_RS23970	COG2197	response regulator
HRM2_RS23975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HRM2_RS23975	COG2226	methyltransferase
HRM2_RS23975	COG0596	Alpha beta hydrolase
HRM2_RS23980	COG0071	Belongs to the small heat shock protein (HSP20) family
HRM2_RS23985	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HRM2_RS23995	COG0842	Transport permease protein
HRM2_RS24000	COG1129	ABC transporter
HRM2_RS24000	COG0842	Transport permease protein
HRM2_RS24005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRM2_RS24015	COG0517	IMP dehydrogenase activity
HRM2_RS24055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRM2_RS24080	COG0697	spore germination
HRM2_RS24085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HRM2_RS24090	COG2086	electron transfer activity
HRM2_RS24095	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS24120	COG4211	Belongs to the binding-protein-dependent transport system permease family
HRM2_RS24130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRM2_RS24135	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HRM2_RS24205	COG3550	peptidyl-serine autophosphorylation
HRM2_RS24315	COG0629	single-stranded DNA binding
HRM2_RS24320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRM2_RS24320	COG0116	Belongs to the methyltransferase superfamily
HRM2_RS24325	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS24330	COG0747	negative chemotaxis
HRM2_RS24335	COG0601	transmembrane transport
HRM2_RS24340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRM2_RS24350	COG4608	Belongs to the ABC transporter superfamily
HRM2_RS24355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRM2_RS24360	COG1127	ABC transporter
HRM2_RS24385	COG0697	spore germination
HRM2_RS24415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRM2_RS24425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRM2_RS24430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRM2_RS24490	COG0187	DNA topoisomerase II activity
HRM2_RS24660	COG4134	Bacterial extracellular solute-binding protein
HRM2_RS24735	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRM2_RS24750	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRM2_RS24805	COG3842	ATPase activity
HRM2_RS24855	COG0247	lactate metabolic process
HRM2_RS24855	COG2181	nitrate reductase activity
HRM2_RS24860	COG0745	RESPONSE REGULATOR receiver
HRM2_RS24865	COG3706	GGDEF domain
HRM2_RS24890	COG0840	transmembrane signaling receptor activity
HRM2_RS24915	COG3267	Type II secretory pathway component ExeA
HRM2_RS24915	COG3409	Peptidoglycan-binding domain 1 protein
HRM2_RS24945	COG0247	lactate metabolic process
HRM2_RS24945	COG2181	nitrate reductase activity
HRM2_RS24965	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRM2_RS24965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRM2_RS24975	COG4942	peptidase
HRM2_RS24985	COG1960	acyl-CoA dehydrogenase activity
HRM2_RS24990	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HRM2_RS25005	COG2897	thiosulfate sulfurtransferase activity
HRM2_RS25010	COG0493	'glutamate synthase
HRM2_RS25010	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRM2_RS25075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HRM2_RS25120	COG0859	PFAM glycosyl transferase family 9
HRM2_RS25160	COG2770	Histidine kinase
HRM2_RS25160	COG3437	response regulator, receiver
HRM2_RS25170	COG2204	response regulator
HRM2_RS25175	COG0739	heme binding
HRM2_RS25195	COG0110	maltose O-acetyltransferase activity
HRM2_RS25220	COG4585	Histidine kinase
HRM2_RS25225	COG1028	Short-chain dehydrogenase reductase Sdr
HRM2_RS25230	COG1028	Short-chain dehydrogenase reductase Sdr
HRM2_RS25240	COG0328	RNA-DNA hybrid ribonuclease activity
HRM2_RS25255	COG2205	protein histidine kinase activity
HRM2_RS25255	COG0784	Response regulator, receiver
HRM2_RS25300	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HRM2_RS25335	COG2204	response regulator
HRM2_RS25340	COG3264	Mechanosensitive ion channel
HRM2_RS25340	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HRM2_RS25355	COG1216	Glycosyl transferase, family 2
HRM2_RS25355	COG0438	transferase activity, transferring glycosyl groups
HRM2_RS25375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRM2_RS25395	COG2203	Gaf domain
HRM2_RS25395	COG3706	GGDEF domain
HRM2_RS25395	COG4251	negative regulation of phosphorylation
HRM2_RS25395	COG5001	Diguanylate cyclase
HRM2_RS25400	COG0328	RNA-DNA hybrid ribonuclease activity
HRM2_RS25435	COG2205	protein histidine kinase activity
HRM2_RS25435	COG2202	Pas domain
HRM2_RS25440	COG2205	protein histidine kinase activity
HRM2_RS25440	COG2202	Pas domain
HRM2_RS25445	COG2203	Gaf domain
HRM2_RS25445	COG3706	GGDEF domain
HRM2_RS25445	COG4251	negative regulation of phosphorylation
HRM2_RS25445	COG5001	Diguanylate cyclase
HRM2_RS25450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRM2_RS25455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HRM2_RS25480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HRM2_RS25490	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HRM2_RS25500	COG0705	Rhomboid family
HRM2_RS25505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRM2_RS25510	COG5002	protein histidine kinase activity
HRM2_RS25515	COG1959	2 iron, 2 sulfur cluster binding
HRM2_RS25545	COG0840	transmembrane signaling receptor activity
HRM2_RS25550	COG3604	Transcriptional regulator
HRM2_RS25625	COG0517	IMP dehydrogenase activity
HRM2_RS25660	COG4191	Histidine kinase
HRM2_RS25665	COG0791	NLP P60 protein
HRM2_RS25690	COG0523	cobalamin synthesis protein