locus-tag	class	description
TOL2_RS00005	COG0592	DNA-directed DNA polymerase activity
TOL2_RS00010	COG0187	DNA topoisomerase II activity
TOL2_RS00040	COG1797	cobyrinic acid a,c-diamide synthase activity
TOL2_RS00045	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TOL2_RS00055	COG0528	UMP kinase activity
TOL2_RS00110	COG2003	Belongs to the UPF0758 family
TOL2_RS00145	COG4807	Protein conserved in bacteria
TOL2_RS00150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TOL2_RS00155	COG1335	isochorismatase
TOL2_RS00165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TOL2_RS00190	COG0702	epimerase
TOL2_RS00200	COG3848	Pyruvate phosphate dikinase
TOL2_RS00200	COG0574	Belongs to the PEP-utilizing enzyme family
TOL2_RS00230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOL2_RS00255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TOL2_RS00255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOL2_RS00260	COG2414	aldehyde ferredoxin oxidoreductase
TOL2_RS00265	COG0437	4 iron, 4 sulfur cluster binding
TOL2_RS00275	COG0577	efflux transmembrane transporter activity
TOL2_RS00290	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TOL2_RS00295	COG4773	Receptor
TOL2_RS00310	COG2226	methyltransferase
TOL2_RS00315	COG2207	Transcriptional regulator
TOL2_RS00350	COG0352	thiamine-phosphate diphosphorylase activity
TOL2_RS00360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TOL2_RS00365	COG2022	thiamine diphosphate biosynthetic process
TOL2_RS00375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TOL2_RS00380	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TOL2_RS00390	COG3118	belongs to the thioredoxin family
TOL2_RS00395	COG1592	Rubrerythrin
TOL2_RS00400	COG0515	serine threonine protein kinase
TOL2_RS00400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TOL2_RS00415	COG1342	Belongs to the UPF0251 family
TOL2_RS00440	COG1160	GTP binding
TOL2_RS00540	COG3852	Histidine kinase
TOL2_RS00555	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TOL2_RS00565	COG3604	Transcriptional regulator
TOL2_RS00575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOL2_RS00605	COG2996	Protein conserved in bacteria
TOL2_RS00620	COG0010	Belongs to the arginase family
TOL2_RS00635	COG1166	arginine decarboxylase activity
TOL2_RS00650	COG2204	response regulator
TOL2_RS00665	COG0745	RESPONSE REGULATOR receiver
TOL2_RS00700	COG1309	transcriptional regulator
TOL2_RS00710	COG2814	Major facilitator Superfamily
TOL2_RS00715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TOL2_RS00720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TOL2_RS00730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TOL2_RS00745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TOL2_RS00760	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TOL2_RS00795	COG1309	transcriptional regulator
TOL2_RS00845	COG0840	transmembrane signaling receptor activity
TOL2_RS00860	COG1028	Short-chain dehydrogenase reductase Sdr
TOL2_RS00865	COG1028	Short-chain dehydrogenase reductase Sdr
TOL2_RS00885	COG1024	Enoyl-CoA hydratase
TOL2_RS00890	COG2086	electron transfer activity
TOL2_RS00895	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TOL2_RS00900	COG2181	nitrate reductase activity
TOL2_RS00900	COG0247	lactate metabolic process
TOL2_RS00905	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
TOL2_RS00915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TOL2_RS00925	COG1053	succinate dehydrogenase
TOL2_RS00930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TOL2_RS00935	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS00945	COG0840	transmembrane signaling receptor activity
TOL2_RS00950	COG0110	maltose O-acetyltransferase activity
TOL2_RS00960	COG1024	Enoyl-CoA hydratase
TOL2_RS00960	COG1250	3-hydroxyacyl-CoA dehydrogenase
TOL2_RS00965	COG0183	Belongs to the thiolase family
TOL2_RS01005	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
TOL2_RS01015	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TOL2_RS01055	COG2226	methyltransferase
TOL2_RS01115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TOL2_RS01120	COG2207	Transcriptional regulator
TOL2_RS01120	COG1917	Cupin 2, conserved barrel domain protein
TOL2_RS01145	COG4974	Belongs to the 'phage' integrase family
TOL2_RS01150	COG4974	Belongs to the 'phage' integrase family
TOL2_RS01175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TOL2_RS01175	COG2111	Na H antiporter
TOL2_RS01180	COG2111	Na H antiporter
TOL2_RS01185	COG1006	Multisubunit Na H antiporter MnhC subunit
TOL2_RS01190	COG0651	ATP synthesis coupled electron transport
TOL2_RS01195	COG1863	multisubunit Na H antiporter MnhE subunit
TOL2_RS01200	COG2212	antiporter activity
TOL2_RS01205	COG1320	monovalent cation:proton antiporter activity
TOL2_RS01225	COG1309	transcriptional regulator
TOL2_RS01230	COG0564	pseudouridine synthase activity
TOL2_RS01240	COG4774	siderophore transport
TOL2_RS01245	COG0288	reversible hydration of carbon dioxide
TOL2_RS01260	COG0640	Transcriptional regulator
TOL2_RS01265	COG0402	S-adenosylhomocysteine deaminase activity
TOL2_RS01300	COG0753	catalase activity
TOL2_RS01325	COG0437	4 iron, 4 sulfur cluster binding
TOL2_RS01360	COG0411	ABC transporter
TOL2_RS01380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TOL2_RS01385	COG0006	proline dipeptidase activity
TOL2_RS01395	COG1773	rubredoxin
TOL2_RS01410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TOL2_RS01420	COG1592	Rubrerythrin
TOL2_RS01430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TOL2_RS01435	COG1509	lysine 2,3-aminomutase activity
TOL2_RS01445	COG1671	Belongs to the UPF0178 family
TOL2_RS01450	COG0004	ammonium transporteR
TOL2_RS01470	COG1104	cysteine desulfurase activity
TOL2_RS01485	COG1045	serine acetyltransferase
TOL2_RS01495	COG0542	response to heat
TOL2_RS01500	COG1643	Atp-dependent helicase
TOL2_RS01505	COG2816	NAD+ diphosphatase activity
TOL2_RS01520	COG2204	response regulator
TOL2_RS01540	COG4771	TonB-dependent receptor
TOL2_RS01565	COG5433	transposase activity
TOL2_RS01575	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TOL2_RS01575	COG0646	methionine synthase
TOL2_RS01600	COG0471	metal ion transport
TOL2_RS01600	COG3273	potassium ion transport
TOL2_RS01630	COG0543	2 iron, 2 sulfur cluster binding
TOL2_RS01635	COG0167	dihydroorotate dehydrogenase activity
TOL2_RS01645	COG0584	glycerophosphoryl diester phosphodiesterase
TOL2_RS01655	COG0439	Biotin carboxylase
TOL2_RS01695	COG0436	Aminotransferase
TOL2_RS01700	COG0303	'Molybdopterin
TOL2_RS01705	COG1910	domain protein
TOL2_RS01725	COG1968	undecaprenyl-diphosphatase activity
TOL2_RS01735	COG0210	DNA helicase
TOL2_RS01745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TOL2_RS01750	COG0747	negative chemotaxis
TOL2_RS01755	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TOL2_RS01810	COG2204	response regulator
TOL2_RS01820	COG1217	gtp-binding protein TYPA
TOL2_RS01825	COG0506	proline dehydrogenase activity
TOL2_RS01870	COG1032	radical SAM domain protein
TOL2_RS01875	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TOL2_RS01905	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TOL2_RS01910	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TOL2_RS01915	COG0217	transcriptional regulatory protein
TOL2_RS01920	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TOL2_RS01925	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TOL2_RS01930	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS01935	COG0443	Heat shock 70 kDa protein
TOL2_RS01940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TOL2_RS01980	COG1278	Cold shock
TOL2_RS01990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TOL2_RS02000	COG0101	tRNA pseudouridine synthase activity
TOL2_RS02010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOL2_RS02035	COG0247	lactate metabolic process
TOL2_RS02035	COG2181	nitrate reductase activity
TOL2_RS02040	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TOL2_RS02045	COG2086	electron transfer activity
TOL2_RS02055	COG3383	formate dehydrogenase (NAD+) activity
TOL2_RS02085	COG0247	lactate metabolic process
TOL2_RS02085	COG2181	nitrate reductase activity
TOL2_RS02095	COG2414	aldehyde ferredoxin oxidoreductase
TOL2_RS02105	COG1024	Enoyl-CoA hydratase
TOL2_RS02110	COG1028	Short-chain dehydrogenase reductase Sdr
TOL2_RS02160	COG0730	response to heat
TOL2_RS02165	COG3383	formate dehydrogenase (NAD+) activity
TOL2_RS02190	COG0243	molybdopterin cofactor binding
TOL2_RS02195	COG0501	Belongs to the peptidase M48B family
TOL2_RS02205	COG2205	protein histidine kinase activity
TOL2_RS02210	COG0745	RESPONSE REGULATOR receiver
TOL2_RS02300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOL2_RS02300	COG0574	Belongs to the PEP-utilizing enzyme family
TOL2_RS02315	COG5002	protein histidine kinase activity
TOL2_RS02335	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TOL2_RS02340	COG2414	aldehyde ferredoxin oxidoreductase
TOL2_RS02350	COG2414	aldehyde ferredoxin oxidoreductase
TOL2_RS02355	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TOL2_RS02355	COG0493	'glutamate synthase
TOL2_RS02360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TOL2_RS02380	COG0484	heat shock protein binding
TOL2_RS02415	COG0544	peptidyl-prolyl cis-trans isomerase activity
TOL2_RS02420	COG0740	serine-type endopeptidase activity
TOL2_RS02425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TOL2_RS02430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOL2_RS02435	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TOL2_RS02450	COG0473	3-isopropylmalate dehydrogenase activity
TOL2_RS02455	COG1278	Cold shock
TOL2_RS02465	COG1233	COG1233 Phytoene dehydrogenase and related
TOL2_RS02470	COG1233	COG1233 Phytoene dehydrogenase and related
TOL2_RS02500	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TOL2_RS02505	COG0590	tRNA wobble adenosine to inosine editing
TOL2_RS02510	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TOL2_RS02515	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TOL2_RS02520	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TOL2_RS02525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TOL2_RS02530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOL2_RS02530	COG0072	phenylalanine-tRNA ligase activity
TOL2_RS02540	COG0779	Required for maturation of 30S ribosomal subunits
TOL2_RS02550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TOL2_RS02555	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TOL2_RS02560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TOL2_RS02565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TOL2_RS02570	COG1185	polyribonucleotide nucleotidyltransferase activity
TOL2_RS02575	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TOL2_RS02580	COG1132	(ABC) transporter
TOL2_RS02585	COG1132	(ABC) transporter
TOL2_RS02590	COG4191	Histidine kinase
TOL2_RS02590	COG0784	Response regulator, receiver
TOL2_RS02595	COG2204	response regulator
TOL2_RS02615	COG0346	lactoylglutathione lyase activity
TOL2_RS02620	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TOL2_RS02620	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TOL2_RS02625	COG1703	isobutyryl-CoA mutase activity
TOL2_RS02635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TOL2_RS02660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TOL2_RS02690	COG1309	transcriptional regulator
TOL2_RS02705	COG1028	Short-chain dehydrogenase reductase Sdr
TOL2_RS02710	COG1028	Short-chain dehydrogenase reductase Sdr
TOL2_RS02730	COG1024	Enoyl-CoA hydratase
TOL2_RS02735	COG2086	electron transfer activity
TOL2_RS02740	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TOL2_RS02745	COG2181	nitrate reductase activity
TOL2_RS02745	COG0247	lactate metabolic process
TOL2_RS02750	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
TOL2_RS02775	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS02785	COG0045	succinate-CoA ligase (ADP-forming) activity
TOL2_RS02790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TOL2_RS02800	COG1053	succinate dehydrogenase
TOL2_RS02805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TOL2_RS02810	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TOL2_RS02810	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TOL2_RS02840	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TOL2_RS02845	COG4191	Histidine kinase
TOL2_RS02845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TOL2_RS02850	COG2204	response regulator
TOL2_RS02855	COG2223	nitrite transmembrane transporter activity
TOL2_RS02860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TOL2_RS02890	COG0432	Pfam Uncharacterised protein family UPF0047
TOL2_RS02900	COG0840	transmembrane signaling receptor activity
TOL2_RS02915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL2_RS02945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOL2_RS02975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TOL2_RS03020	COG0741	lytic transglycosylase activity
TOL2_RS03025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TOL2_RS03035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TOL2_RS03050	COG2221	Nitrite and sulphite reductase 4Fe-4S
TOL2_RS03055	COG2221	Nitrite and sulphite reductase 4Fe-4S
TOL2_RS03065	COG1797	cobyrinic acid a,c-diamide synthase activity
TOL2_RS03075	COG0805	protein transport
TOL2_RS03080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOL2_RS03105	COG3599	regulation of cell shape
TOL2_RS03130	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TOL2_RS03155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TOL2_RS03160	COG0735	belongs to the Fur family
TOL2_RS03165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOL2_RS03165	COG1918	ferrous iron import across plasma membrane
TOL2_RS03180	COG2204	response regulator
TOL2_RS03185	COG4191	Histidine kinase
TOL2_RS03225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TOL2_RS03230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TOL2_RS03235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TOL2_RS03250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TOL2_RS03280	COG0583	DNA-binding transcription factor activity
TOL2_RS03285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TOL2_RS03290	COG0742	ribosomal rna small subunit methyltransferase
TOL2_RS03300	COG5000	phosphorelay sensor kinase activity
TOL2_RS03310	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TOL2_RS03315	COG0606	chelatase, subunit chli
TOL2_RS03325	COG3040	lipid binding
TOL2_RS03375	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS03380	COG4372	Transposase
TOL2_RS03430	COG0606	chelatase, subunit chli
TOL2_RS03440	COG3040	lipid binding
TOL2_RS03470	COG1132	(ABC) transporter
TOL2_RS03535	COG4372	Transposase
TOL2_RS03540	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS03550	COG1431	PFAM Stem cell self-renewal protein Piwi
TOL2_RS03575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TOL2_RS03595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TOL2_RS03600	COG0604	alcohol dehydrogenase
TOL2_RS03605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TOL2_RS03610	COG2204	response regulator
TOL2_RS03625	COG1242	4 iron, 4 sulfur cluster binding
TOL2_RS03630	COG1477	protein flavinylation
TOL2_RS03650	COG2226	methyltransferase
TOL2_RS03665	COG1024	Enoyl-CoA hydratase
TOL2_RS03670	COG1960	acyl-CoA dehydrogenase activity
TOL2_RS03675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TOL2_RS03690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TOL2_RS03690	COG1703	isobutyryl-CoA mutase activity
TOL2_RS03690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TOL2_RS03700	COG1250	3-hydroxyacyl-CoA dehydrogenase
TOL2_RS03740	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS03745	COG0411	ABC transporter
TOL2_RS03750	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS03755	COG5002	protein histidine kinase activity
TOL2_RS03760	COG2205	protein histidine kinase activity
TOL2_RS03770	COG0156	8-amino-7-oxononanoate synthase activity
TOL2_RS03775	COG1063	alcohol dehydrogenase
TOL2_RS03790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TOL2_RS03795	COG0662	Cupin 2, conserved barrel domain protein
TOL2_RS03800	COG1960	acyl-CoA dehydrogenase activity
TOL2_RS03830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TOL2_RS03835	COG1459	type II secretion system
TOL2_RS03840	COG4969	Belongs to the N-Me-Phe pilin family
TOL2_RS03900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOL2_RS03915	COG1136	(ABC) transporter
TOL2_RS03920	COG4591	ABC-type transport system involved in lipoprotein release permease component
TOL2_RS03940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOL2_RS03950	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TOL2_RS03955	COG0409	Hydrogenase expression formation protein
TOL2_RS03965	COG0824	Thioesterase
TOL2_RS03970	COG1993	acr, cog1993
TOL2_RS03975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TOL2_RS04010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOL2_RS04015	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
TOL2_RS04020	COG0437	4 iron, 4 sulfur cluster binding
TOL2_RS04030	COG0438	transferase activity, transferring glycosyl groups
TOL2_RS04030	COG0297	glycogen (starch) synthase activity
TOL2_RS04040	COG0116	Belongs to the methyltransferase superfamily
TOL2_RS04045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TOL2_RS04070	COG2264	protein methyltransferase activity
TOL2_RS04075	COG3153	acetyltransferase
TOL2_RS04090	COG0427	acetyl-CoA hydrolase
TOL2_RS04125	COG0840	transmembrane signaling receptor activity
TOL2_RS04140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TOL2_RS04145	COG0436	Aminotransferase
TOL2_RS04150	COG2199	diguanylate cyclase activity
TOL2_RS04150	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TOL2_RS04165	COG0012	GTP binding
TOL2_RS04205	COG3944	biosynthesis protein
TOL2_RS04210	COG0489	protein tyrosine kinase activity
TOL2_RS04215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TOL2_RS04225	COG3550	peptidyl-serine autophosphorylation
TOL2_RS04230	COG3550	peptidyl-serine autophosphorylation
TOL2_RS04240	COG2026	Addiction module toxin, RelE StbE family
TOL2_RS04300	COG1598	PFAM Uncharacterised protein family UPF0150
TOL2_RS04330	COG5464	transposase or invertase
TOL2_RS04370	COG1086	Polysaccharide biosynthesis protein
TOL2_RS04380	COG1086	Polysaccharide biosynthesis protein
TOL2_RS04390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TOL2_RS04395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TOL2_RS04400	COG2226	methyltransferase
TOL2_RS04405	COG1215	transferase activity, transferring glycosyl groups
TOL2_RS04420	COG1086	Polysaccharide biosynthesis protein
TOL2_RS04430	COG0438	transferase activity, transferring glycosyl groups
TOL2_RS04460	COG1088	dTDP-glucose 4,6-dehydratase activity
TOL2_RS04530	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TOL2_RS04535	COG2361	Protein of unknown function DUF86
TOL2_RS04600	COG2361	Protein of unknown function DUF86
TOL2_RS04640	COG2046	Belongs to the sulfate adenylyltransferase family
TOL2_RS04640	COG0529	Catalyzes the synthesis of activated sulfate
TOL2_RS04650	COG0521	Mo-molybdopterin cofactor biosynthetic process
TOL2_RS04655	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TOL2_RS04660	COG0746	molybdenum cofactor guanylyltransferase activity
TOL2_RS04670	COG0315	cyclic pyranopterin monophosphate synthase activity
TOL2_RS04675	COG1322	Protein conserved in bacteria
TOL2_RS04680	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
TOL2_RS04690	COG4662	Binding-protein-dependent transport system inner membrane component
TOL2_RS04695	COG2998	abc-type tungstate transport system, permease component
TOL2_RS04715	COG1648	precorrin-2 dehydrogenase activity
TOL2_RS04715	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TOL2_RS04720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TOL2_RS04725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TOL2_RS04735	COG0571	ribonuclease III activity
TOL2_RS04755	COG3437	response regulator, receiver
TOL2_RS04760	COG4251	negative regulation of phosphorylation
TOL2_RS04760	COG5001	Diguanylate cyclase
TOL2_RS04760	COG3706	GGDEF domain
TOL2_RS04760	COG2203	Gaf domain
TOL2_RS04775	COG4106	trans-aconitate 2-methyltransferase activity
TOL2_RS04780	COG1506	peptidase
TOL2_RS04780	COG0823	Involved in the tonB-independent uptake of proteins
TOL2_RS04790	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TOL2_RS04800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TOL2_RS04800	COG2226	methyltransferase
TOL2_RS04800	COG0596	Alpha beta hydrolase
TOL2_RS04815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TOL2_RS04825	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TOL2_RS04845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOL2_RS04860	COG0179	Fumarylacetoacetate (FAA) hydrolase
TOL2_RS04885	COG1605	Chorismate mutase
TOL2_RS04885	COG0287	Prephenate dehydrogenase
TOL2_RS04895	COG3852	Histidine kinase
TOL2_RS04920	COG0247	lactate metabolic process
TOL2_RS04965	COG0840	transmembrane signaling receptor activity
TOL2_RS04995	COG4771	TonB-dependent receptor
TOL2_RS05020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOL2_RS05025	COG1120	ATPase activity
TOL2_RS05035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TOL2_RS05040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOL2_RS05045	COG1120	ATPase activity
TOL2_RS05065	COG2226	methyltransferase
TOL2_RS05085	COG3383	formate dehydrogenase (NAD+) activity
TOL2_RS05090	COG3383	formate dehydrogenase (NAD+) activity
TOL2_RS05095	COG3383	formate dehydrogenase (NAD+) activity
TOL2_RS05115	COG0784	Response regulator, receiver
TOL2_RS05120	COG2268	Band 7 protein
TOL2_RS05145	COG4771	TonB-dependent receptor
TOL2_RS05160	COG1120	ATPase activity
TOL2_RS05165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOL2_RS05175	COG4206	TonB-dependent receptor
TOL2_RS05185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TOL2_RS05190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOL2_RS05195	COG1120	ATPase activity
TOL2_RS05240	COG1518	maintenance of DNA repeat elements
TOL2_RS05245	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TOL2_RS05250	COG4372	Transposase
TOL2_RS05255	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS05285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOL2_RS05320	COG0045	succinate-CoA ligase (ADP-forming) activity
TOL2_RS05320	COG1042	CoA-binding domain protein
TOL2_RS05320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TOL2_RS05335	COG1032	radical SAM domain protein
TOL2_RS05345	COG1151	hydroxylamine reductase activity
TOL2_RS05355	COG0189	ligase activity
TOL2_RS05355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TOL2_RS05380	COG0009	L-threonylcarbamoyladenylate synthase
TOL2_RS05390	COG1181	Belongs to the D-alanine--D-alanine ligase family
TOL2_RS05410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TOL2_RS05435	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TOL2_RS05455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TOL2_RS05470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TOL2_RS05480	COG3437	response regulator, receiver
TOL2_RS05490	COG0747	negative chemotaxis
TOL2_RS05500	COG0138	bifunctional purine biosynthesis protein purh
TOL2_RS05505	COG0557	exoribonuclease II activity
TOL2_RS05515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TOL2_RS05525	COG4657	Part of a membrane complex involved in electron transport
TOL2_RS05530	COG4660	Part of a membrane complex involved in electron transport
TOL2_RS05535	COG4659	FMN binding
TOL2_RS05540	COG4658	electron transport chain
TOL2_RS05585	COG0488	(ABC) transporter
TOL2_RS05620	COG0765	amino acid transport
TOL2_RS05640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TOL2_RS05645	COG0573	inorganic phosphate transmembrane transporter activity
TOL2_RS05650	COG0581	inorganic phosphate transmembrane transporter activity
TOL2_RS05655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TOL2_RS05670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TOL2_RS05675	COG1121	(ABC) transporter
TOL2_RS05685	COG2204	response regulator
TOL2_RS05690	COG5002	protein histidine kinase activity
TOL2_RS05695	COG0745	RESPONSE REGULATOR receiver
TOL2_RS05710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOL2_RS05720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TOL2_RS05760	COG0076	glutamate decarboxylase activity
TOL2_RS05770	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TOL2_RS05775	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TOL2_RS05780	COG0628	permease
TOL2_RS05795	COG1595	DNA-templated transcription, initiation
TOL2_RS05805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TOL2_RS05810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TOL2_RS05810	COG1587	Uroporphyrinogen-III synthase
TOL2_RS05815	COG0181	hydroxymethylbilane synthase activity
TOL2_RS05820	COG5002	protein histidine kinase activity
TOL2_RS05830	COG2204	response regulator
TOL2_RS05845	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TOL2_RS05855	COG1921	L-seryl-tRNASec selenium transferase activity
TOL2_RS05860	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TOL2_RS05880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TOL2_RS05880	COG0045	succinate-CoA ligase (ADP-forming) activity
TOL2_RS05880	COG1042	CoA-binding domain protein
TOL2_RS05885	COG0284	orotidine-5'-phosphate decarboxylase activity
TOL2_RS05890	COG0527	aspartate kinase activity
TOL2_RS05895	COG0802	atpase or kinase
TOL2_RS05900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TOL2_RS05900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TOL2_RS05905	COG0519	Catalyzes the synthesis of GMP from XMP
TOL2_RS05920	COG0835	chemotaxis
TOL2_RS05925	COG0840	transmembrane signaling receptor activity
TOL2_RS05935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOL2_RS05945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TOL2_RS05950	COG0215	cysteine-tRNA ligase activity
TOL2_RS05955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOL2_RS05960	COG0488	(ABC) transporter
TOL2_RS05965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TOL2_RS05980	COG0556	nucleotide-excision repair
TOL2_RS05985	COG0322	excinuclease ABC activity
TOL2_RS05990	COG0539	negative regulation of cytoplasmic translation
TOL2_RS05990	COG2183	response to ionizing radiation
TOL2_RS06000	COG0561	phosphatase activity
TOL2_RS06005	COG2204	response regulator
TOL2_RS06025	COG2204	response regulator
TOL2_RS06030	COG0659	secondary active sulfate transmembrane transporter activity
TOL2_RS06035	COG1309	transcriptional regulator
TOL2_RS06040	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TOL2_RS06045	COG0745	RESPONSE REGULATOR receiver
TOL2_RS06050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TOL2_RS06055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TOL2_RS06060	COG1480	7TM receptor with intracellular HD hydrolase
TOL2_RS06065	COG1702	phosphate starvation-inducible protein PhoH
TOL2_RS06075	COG3956	TIGRFAM MazG family protein
TOL2_RS06100	COG1309	transcriptional regulator
TOL2_RS06105	COG0247	lactate metabolic process
TOL2_RS06105	COG2181	nitrate reductase activity
TOL2_RS06115	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TOL2_RS06120	COG3875	lactate racemase activity
TOL2_RS06130	COG0277	FAD linked oxidase domain protein
TOL2_RS06135	COG2871	sodium ion transport
TOL2_RS06155	COG0784	Response regulator, receiver
TOL2_RS06175	COG0183	Belongs to the thiolase family
TOL2_RS06185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TOL2_RS06190	COG0154	amidase activity
TOL2_RS06195	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TOL2_RS06260	COG0446	pyridine nucleotide-disulphide oxidoreductase
TOL2_RS06280	COG1233	COG1233 Phytoene dehydrogenase and related
TOL2_RS06295	COG3383	formate dehydrogenase (NAD+) activity
TOL2_RS06300	COG3383	formate dehydrogenase (NAD+) activity
TOL2_RS06345	COG0243	molybdopterin cofactor binding
TOL2_RS06350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TOL2_RS06380	COG1151	hydroxylamine reductase activity
TOL2_RS06390	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TOL2_RS06395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TOL2_RS06400	COG3404	Formiminotransferase-cyclodeaminase
TOL2_RS06415	COG0840	transmembrane signaling receptor activity
TOL2_RS06420	COG0045	succinate-CoA ligase (ADP-forming) activity
TOL2_RS06420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TOL2_RS06420	COG1042	CoA-binding domain protein
TOL2_RS06435	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TOL2_RS06445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TOL2_RS06450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TOL2_RS06455	COG0193	aminoacyl-tRNA hydrolase activity
TOL2_RS06465	COG0564	pseudouridine synthase activity
TOL2_RS06470	COG3383	formate dehydrogenase (NAD+) activity
TOL2_RS06475	COG3383	formate dehydrogenase (NAD+) activity
TOL2_RS06480	COG2878	Part of a membrane complex involved in electron transport
TOL2_RS06480	COG1245	4Fe-4S binding domain
TOL2_RS06490	COG1227	inorganic diphosphatase activity
TOL2_RS06500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TOL2_RS06510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TOL2_RS06515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TOL2_RS06520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOL2_RS06525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TOL2_RS06535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TOL2_RS06540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TOL2_RS06545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TOL2_RS06560	COG0275	rRNA processing
TOL2_RS06565	COG2001	Belongs to the MraZ family
TOL2_RS06585	COG1131	(ABC) transporter
TOL2_RS06595	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TOL2_RS06605	COG1268	BioY protein
TOL2_RS06610	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TOL2_RS06610	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TOL2_RS06615	COG3829	transcription factor binding
TOL2_RS06620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TOL2_RS06625	COG5598	trimethylamine methyltransferase
TOL2_RS06635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TOL2_RS06640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TOL2_RS06655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TOL2_RS06680	COG1564	THIamine pyrophosphokinase
TOL2_RS06695	COG1519	Transferase
TOL2_RS06700	COG1663	tetraacyldisaccharide 4'-kinase activity
TOL2_RS06705	COG1560	Kdo2-lipid A biosynthetic process
TOL2_RS06710	COG0859	PFAM glycosyl transferase family 9
TOL2_RS06740	COG0297	glycogen (starch) synthase activity
TOL2_RS06745	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TOL2_RS06750	COG1454	alcohol dehydrogenase
TOL2_RS06755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TOL2_RS06765	COG1216	Glycosyl transferase, family 2
TOL2_RS06765	COG0463	Glycosyl transferase, family 2
TOL2_RS06775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TOL2_RS06840	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TOL2_RS06845	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TOL2_RS06860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TOL2_RS06885	COG3604	Transcriptional regulator
TOL2_RS06915	COG4452	Inner membrane protein CreD
TOL2_RS06935	COG3604	Transcriptional regulator
TOL2_RS06940	COG2151	metal-sulfur cluster biosynthetic enzyme
TOL2_RS07000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOL2_RS07005	COG0826	peptidase U32
TOL2_RS07010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TOL2_RS07015	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
TOL2_RS07020	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TOL2_RS07025	COG0351	phosphomethylpyrimidine kinase
TOL2_RS07035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TOL2_RS07040	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TOL2_RS07065	COG0028	Belongs to the TPP enzyme family
TOL2_RS07070	COG0674	pyruvate-flavodoxin oxidoreductase activity
TOL2_RS07070	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TOL2_RS07075	COG1280	lysine exporter protein (LysE YggA)
TOL2_RS07100	COG2204	response regulator
TOL2_RS07125	COG3852	Histidine kinase
TOL2_RS07130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TOL2_RS07140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOL2_RS07140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOL2_RS07145	COG1774	PSP1 C-terminal conserved region
TOL2_RS07150	COG0470	DNA polymerase III
TOL2_RS07155	COG0776	regulation of translation
TOL2_RS07165	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TOL2_RS07170	COG0215	cysteine-tRNA ligase activity
TOL2_RS07185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TOL2_RS07205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TOL2_RS07220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TOL2_RS07225	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TOL2_RS07230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TOL2_RS07240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TOL2_RS07270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TOL2_RS07275	COG0459	protein refolding
TOL2_RS07295	COG0823	Involved in the tonB-independent uptake of proteins
TOL2_RS07300	COG2885	chlorophyll binding
TOL2_RS07310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TOL2_RS07315	COG0632	four-way junction helicase activity
TOL2_RS07320	COG2255	four-way junction helicase activity
TOL2_RS07335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TOL2_RS07340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TOL2_RS07345	COG2925	Exonuclease
TOL2_RS07350	COG0776	regulation of translation
TOL2_RS07360	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TOL2_RS07365	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOL2_RS07370	COG1214	PFAM Peptidase M22, glycoprotease
TOL2_RS07375	COG0688	phosphatidylethanolamine metabolic process
TOL2_RS07380	COG1183	phosphatidylcholine synthase activity
TOL2_RS07385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TOL2_RS07390	COG1758	RNA polymerase activity
TOL2_RS07395	COG0037	tRNA processing
TOL2_RS07400	COG1469	GTP cyclohydrolase I activity
TOL2_RS07410	COG1362	aminopeptidase activity
TOL2_RS07445	COG2165	general secretion pathway protein
TOL2_RS07485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TOL2_RS07495	COG1459	type II secretion system
TOL2_RS07510	COG3852	Histidine kinase
TOL2_RS07515	COG2204	response regulator
TOL2_RS07555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL2_RS07610	COG1696	Membrane protein involved in D-alanine export
TOL2_RS07680	COG1484	DNA-dependent DNA replication
TOL2_RS07685	COG4584	PFAM Integrase catalytic
TOL2_RS07745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TOL2_RS07745	COG0519	Catalyzes the synthesis of GMP from XMP
TOL2_RS07750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TOL2_RS07755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TOL2_RS07760	COG0758	DNA mediated transformation
TOL2_RS07770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TOL2_RS07775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TOL2_RS07780	COG1862	Preprotein translocase
TOL2_RS07790	COG1530	ribonuclease E activity
TOL2_RS07795	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TOL2_RS07800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TOL2_RS07820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOL2_RS07820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOL2_RS07825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOL2_RS07830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TOL2_RS07865	COG0009	L-threonylcarbamoyladenylate synthase
TOL2_RS07880	COG4999	Histidine kinase
TOL2_RS07880	COG3850	Histidine kinase
TOL2_RS07880	COG3437	response regulator, receiver
TOL2_RS07880	COG2205	protein histidine kinase activity
TOL2_RS07885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TOL2_RS07905	COG0484	heat shock protein binding
TOL2_RS07935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TOL2_RS07945	COG0310	cobalt ion transport
TOL2_RS07955	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TOL2_RS07960	COG1122	ATPase activity
TOL2_RS07970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TOL2_RS07970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TOL2_RS07980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOL2_RS07985	COG0024	Methionine aminopeptidase
TOL2_RS07990	COG0204	Acyl-transferase
TOL2_RS08005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TOL2_RS08010	COG0515	serine threonine protein kinase
TOL2_RS08010	COG2815	serine threonine protein kinase
TOL2_RS08015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TOL2_RS08015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TOL2_RS08020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TOL2_RS08025	COG0242	peptide deformylase activity
TOL2_RS08030	COG0196	riboflavin kinase activity
TOL2_RS08055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TOL2_RS08060	COG3547	Transposase (IS116 IS110 IS902 family)
TOL2_RS08065	COG4584	PFAM Integrase catalytic
TOL2_RS08070	COG1484	DNA-dependent DNA replication
TOL2_RS08100	COG3547	Transposase (IS116 IS110 IS902 family)
TOL2_RS08115	COG3852	Histidine kinase
TOL2_RS08120	COG0747	negative chemotaxis
TOL2_RS08135	COG0436	Aminotransferase
TOL2_RS08145	COG0076	glutamate decarboxylase activity
TOL2_RS08160	COG2197	response regulator
TOL2_RS08165	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS08170	COG0659	secondary active sulfate transmembrane transporter activity
TOL2_RS08175	COG1960	acyl-CoA dehydrogenase activity
TOL2_RS08180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TOL2_RS08185	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TOL2_RS08220	COG1845	cytochrome c oxidase, subunit III
TOL2_RS08285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOL2_RS08285	COG3153	acetyltransferase
TOL2_RS08290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TOL2_RS08290	COG0731	radical SAM domain protein
TOL2_RS08300	COG0714	Associated with various cellular activities
TOL2_RS08330	COG0693	protein deglycase activity
TOL2_RS08335	COG4191	Histidine kinase
TOL2_RS08340	COG2204	response regulator
TOL2_RS08355	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TOL2_RS08365	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TOL2_RS08370	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TOL2_RS08375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TOL2_RS08380	COG2204	response regulator
TOL2_RS08385	COG3852	Histidine kinase
TOL2_RS08425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TOL2_RS08450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TOL2_RS08465	COG1509	lysine 2,3-aminomutase activity
TOL2_RS08470	COG0174	glutamine synthetase
TOL2_RS08475	COG1846	Transcriptional regulator
TOL2_RS08495	COG2068	MobA-Related Protein
TOL2_RS08500	COG1058	Belongs to the CinA family
TOL2_RS08500	COG1546	Belongs to the CinA family
TOL2_RS08510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TOL2_RS08570	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TOL2_RS08590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOL2_RS08590	COG0574	Belongs to the PEP-utilizing enzyme family
TOL2_RS08595	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TOL2_RS08635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TOL2_RS08635	COG2080	2 iron, 2 sulfur cluster binding
TOL2_RS08650	COG3706	GGDEF domain
TOL2_RS08650	COG2203	Gaf domain
TOL2_RS08650	COG5001	Diguanylate cyclase
TOL2_RS08650	COG4251	negative regulation of phosphorylation
TOL2_RS08670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TOL2_RS08680	COG1519	Transferase
TOL2_RS08685	COG1132	(ABC) transporter
TOL2_RS08695	COG1561	YicC-like family, N-terminal region
TOL2_RS08700	COG2052	Domain of unknown function (DUF370)
TOL2_RS08705	COG0194	GDP metabolic process
TOL2_RS08710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOL2_RS08715	COG1040	competence protein
TOL2_RS08735	COG0840	transmembrane signaling receptor activity
TOL2_RS08750	COG1606	tRNA processing
TOL2_RS08755	COG0105	UTP biosynthetic process
TOL2_RS08760	COG0237	dephospho-CoA kinase activity
TOL2_RS08765	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TOL2_RS08770	COG0254	rRNA binding
TOL2_RS08775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TOL2_RS08780	COG2890	protein-(glutamine-N5) methyltransferase activity
TOL2_RS08785	COG0052	Belongs to the universal ribosomal protein uS2 family
TOL2_RS08790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TOL2_RS08795	COG0528	UMP kinase activity
TOL2_RS08800	COG0233	cytoplasmic translational termination
TOL2_RS08805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TOL2_RS08815	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TOL2_RS08820	COG0750	zinc metalloprotease
TOL2_RS08825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TOL2_RS08830	COG0047	phosphoribosylformylglycinamidine synthase activity
TOL2_RS08860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TOL2_RS08870	COG0525	valine-tRNA ligase activity
TOL2_RS08885	COG0481	GTPase activity
TOL2_RS08895	COG1024	Enoyl-CoA hydratase
TOL2_RS08915	COG1595	DNA-templated transcription, initiation
TOL2_RS08925	COG3706	GGDEF domain
TOL2_RS08930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOL2_RS08935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOL2_RS08940	COG0440	acetolactate synthase activity
TOL2_RS08945	COG0028	Belongs to the TPP enzyme family
TOL2_RS08950	COG0129	dihydroxy-acid dehydratase activity
TOL2_RS08965	COG1691	(AIR) carboxylase
TOL2_RS08975	COG4106	trans-aconitate 2-methyltransferase activity
TOL2_RS08980	COG0500	methyltransferase
TOL2_RS08995	COG1201	RNA secondary structure unwinding
TOL2_RS09015	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TOL2_RS09030	COG0071	Belongs to the small heat shock protein (HSP20) family
TOL2_RS09070	COG0509	glycine decarboxylation via glycine cleavage system
TOL2_RS09080	COG2204	response regulator
TOL2_RS09110	COG3530	Putative quorum-sensing-regulated virulence factor
TOL2_RS09130	COG3360	Dodecin
TOL2_RS09150	COG3089	Belongs to the UPF0270 family
TOL2_RS09160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TOL2_RS09195	COG2894	cell division
TOL2_RS09215	COG1127	ABC transporter
TOL2_RS09220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TOL2_RS09230	COG1366	Belongs to the anti-sigma-factor antagonist family
TOL2_RS09250	COG1090	epimerase
TOL2_RS09270	COG0708	Exodeoxyribonuclease III
TOL2_RS09280	COG0372	Belongs to the citrate synthase family
TOL2_RS09295	COG1304	FMN binding
TOL2_RS09300	COG0655	NAD(P)H dehydrogenase (quinone) activity
TOL2_RS09305	COG3118	belongs to the thioredoxin family
TOL2_RS09320	COG2033	superoxide reductase activity
TOL2_RS09330	COG0426	domain, Protein
TOL2_RS09335	COG1773	rubredoxin
TOL2_RS09360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TOL2_RS09395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TOL2_RS09400	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TOL2_RS09425	COG1294	oxidase, subunit
TOL2_RS09430	COG1271	oxidase subunit
TOL2_RS09440	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
TOL2_RS09475	COG0437	4 iron, 4 sulfur cluster binding
TOL2_RS09485	COG2954	triphosphatase activity
TOL2_RS09500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TOL2_RS09515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TOL2_RS09520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TOL2_RS09525	COG1902	pentaerythritol trinitrate reductase activity
TOL2_RS09525	COG0446	pyridine nucleotide-disulphide oxidoreductase
TOL2_RS09530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TOL2_RS09605	COG2204	response regulator
TOL2_RS09610	COG0643	Histidine kinase
TOL2_RS09610	COG2198	Histidine kinase
TOL2_RS09615	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TOL2_RS09625	COG0745	RESPONSE REGULATOR receiver
TOL2_RS09635	COG2201	protein-glutamate methylesterase activity
TOL2_RS09640	COG0513	Belongs to the DEAD box helicase family
TOL2_RS09655	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TOL2_RS09670	COG2226	methyltransferase
TOL2_RS09675	COG0438	transferase activity, transferring glycosyl groups
TOL2_RS09675	COG0297	glycogen (starch) synthase activity
TOL2_RS09695	COG0563	adenylate kinase activity
TOL2_RS09700	COG1151	hydroxylamine reductase activity
TOL2_RS09710	COG0148	phosphopyruvate hydratase activity
TOL2_RS09720	COG0504	CTP synthase activity
TOL2_RS09745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TOL2_RS09750	COG1522	sequence-specific DNA binding
TOL2_RS09760	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS09800	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TOL2_RS09800	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TOL2_RS09805	COG1496	oxidoreductase activity
TOL2_RS09810	COG0709	Synthesizes selenophosphate from selenide and ATP
TOL2_RS09825	COG0356	it plays a direct role in the translocation of protons across the membrane
TOL2_RS09830	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TOL2_RS09840	COG1192	Involved in chromosome partitioning
TOL2_RS09850	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TOL2_RS09855	COG1024	Enoyl-CoA hydratase
TOL2_RS09865	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TOL2_RS09885	COG1228	amidohydrolase
TOL2_RS09890	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TOL2_RS09895	COG2986	histidine ammonia-lyase
TOL2_RS09910	COG0489	protein tyrosine kinase activity
TOL2_RS09960	COG4372	Transposase
TOL2_RS09965	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS09985	COG1484	DNA-dependent DNA replication
TOL2_RS09990	COG4584	PFAM Integrase catalytic
TOL2_RS10020	COG4372	Transposase
TOL2_RS10025	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS10055	COG4974	Belongs to the 'phage' integrase family
TOL2_RS10065	COG3153	acetyltransferase
TOL2_RS10065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOL2_RS10070	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TOL2_RS10075	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TOL2_RS10080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TOL2_RS10085	COG0277	FAD linked oxidase domain protein
TOL2_RS10095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TOL2_RS10115	COG0488	(ABC) transporter
TOL2_RS10130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TOL2_RS10135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOL2_RS10150	COG1333	cytochrome c biogenesis protein
TOL2_RS10155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TOL2_RS10165	COG0243	molybdopterin cofactor binding
TOL2_RS10170	COG0437	4 iron, 4 sulfur cluster binding
TOL2_RS10175	COG5557	Pfam Polysulphide reductase, NrfD
TOL2_RS10200	COG2201	protein-glutamate methylesterase activity
TOL2_RS10205	COG0643	Histidine kinase
TOL2_RS10205	COG2198	Histidine kinase
TOL2_RS10205	COG0784	Response regulator, receiver
TOL2_RS10215	COG0835	chemotaxis
TOL2_RS10230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TOL2_RS10240	COG2204	response regulator
TOL2_RS10250	COG2181	nitrate reductase activity
TOL2_RS10255	COG0247	lactate metabolic process
TOL2_RS10265	COG2204	response regulator
TOL2_RS10275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOL2_RS10310	COG0517	IMP dehydrogenase activity
TOL2_RS10310	COG0617	tRNA 3'-terminal CCA addition
TOL2_RS10310	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TOL2_RS10315	COG0589	response to stress
TOL2_RS10335	COG1584	GPR1 FUN34 yaaH family protein
TOL2_RS10345	COG2204	response regulator
TOL2_RS10360	COG2204	response regulator
TOL2_RS10365	COG0471	metal ion transport
TOL2_RS10375	COG2204	response regulator
TOL2_RS10380	COG0517	IMP dehydrogenase activity
TOL2_RS10380	COG0516	GMP reductase activity
TOL2_RS10395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TOL2_RS10395	COG0045	succinate-CoA ligase (ADP-forming) activity
TOL2_RS10395	COG1042	CoA-binding domain protein
TOL2_RS10415	COG2204	response regulator
TOL2_RS10425	COG4191	Histidine kinase
TOL2_RS10440	COG2204	response regulator
TOL2_RS10455	COG0651	ATP synthesis coupled electron transport
TOL2_RS10460	COG0650	Formate hydrogenlyase subunit 4
TOL2_RS10470	COG0651	ATP synthesis coupled electron transport
TOL2_RS10475	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOL2_RS10475	COG0649	NAD binding
TOL2_RS10480	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOL2_RS10485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOL2_RS10500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TOL2_RS10505	COG0826	peptidase U32
TOL2_RS10515	COG1619	proteins homologs of microcin C7 resistance protein MccF
TOL2_RS10520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TOL2_RS10525	COG1077	Cell shape determining protein MreB Mrl
TOL2_RS10540	COG0768	penicillin binding
TOL2_RS10545	COG0772	Belongs to the SEDS family
TOL2_RS10550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TOL2_RS10555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TOL2_RS10560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TOL2_RS10565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TOL2_RS10570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TOL2_RS10575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TOL2_RS10580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TOL2_RS10600	COG1418	mRNA catabolic process
TOL2_RS10605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TOL2_RS10640	COG1722	exodeoxyribonuclease VII activity
TOL2_RS10650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TOL2_RS10655	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TOL2_RS10660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TOL2_RS10670	COG1597	lipid kinase activity
TOL2_RS10685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TOL2_RS10700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TOL2_RS10705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TOL2_RS10710	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TOL2_RS10715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TOL2_RS10720	COG1605	Chorismate mutase
TOL2_RS10720	COG0077	Prephenate dehydratase
TOL2_RS10725	COG4536	flavin adenine dinucleotide binding
TOL2_RS10730	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOL2_RS10735	COG3494	Protein of unknown function (DUF1009)
TOL2_RS10740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOL2_RS10745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOL2_RS10755	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TOL2_RS10760	COG1136	(ABC) transporter
TOL2_RS10770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TOL2_RS10780	COG1459	type II secretion system
TOL2_RS10785	COG3620	sequence-specific DNA binding
TOL2_RS10785	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TOL2_RS10785	COG0617	tRNA 3'-terminal CCA addition
TOL2_RS10795	COG1187	pseudouridine synthase activity
TOL2_RS10800	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TOL2_RS10825	COG3344	reverse transcriptase
TOL2_RS10835	COG3344	reverse transcriptase
TOL2_RS10860	COG0517	IMP dehydrogenase activity
TOL2_RS10865	COG4974	Belongs to the 'phage' integrase family
TOL2_RS10890	COG3344	reverse transcriptase
TOL2_RS10910	COG3344	reverse transcriptase
TOL2_RS10915	COG0517	IMP dehydrogenase activity
TOL2_RS10920	COG4974	Belongs to the 'phage' integrase family
TOL2_RS10930	COG3344	reverse transcriptase
TOL2_RS10940	COG3344	reverse transcriptase
TOL2_RS10945	COG0517	IMP dehydrogenase activity
TOL2_RS10950	COG4974	Belongs to the 'phage' integrase family
TOL2_RS10960	COG0517	IMP dehydrogenase activity
TOL2_RS10965	COG4974	Belongs to the 'phage' integrase family
TOL2_RS10980	COG3344	reverse transcriptase
TOL2_RS10990	COG3344	reverse transcriptase
TOL2_RS11000	COG3344	reverse transcriptase
TOL2_RS11010	COG3344	reverse transcriptase
TOL2_RS11025	COG0517	IMP dehydrogenase activity
TOL2_RS11030	COG4974	Belongs to the 'phage' integrase family
TOL2_RS11045	COG3344	reverse transcriptase
TOL2_RS11075	COG3344	reverse transcriptase
TOL2_RS11085	COG3344	reverse transcriptase
TOL2_RS11125	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS11130	COG4372	Transposase
TOL2_RS11155	COG3344	reverse transcriptase
TOL2_RS11180	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
TOL2_RS11190	COG3344	reverse transcriptase
TOL2_RS11200	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS11205	COG4372	Transposase
TOL2_RS11225	COG3344	reverse transcriptase
TOL2_RS11235	COG0517	IMP dehydrogenase activity
TOL2_RS11240	COG4974	Belongs to the 'phage' integrase family
TOL2_RS11285	COG0509	glycine decarboxylation via glycine cleavage system
TOL2_RS11290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TOL2_RS11295	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TOL2_RS11300	COG0321	lipoyl(octanoyl) transferase activity
TOL2_RS11305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TOL2_RS11310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TOL2_RS11330	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TOL2_RS11335	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TOL2_RS11340	COG0357	Ribosomal RNA small subunit methyltransferase G
TOL2_RS11345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TOL2_RS11370	COG0482	sulfurtransferase activity
TOL2_RS11375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOL2_RS11380	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TOL2_RS11390	COG2823	Periplasmic or secreted lipoprotein
TOL2_RS11395	COG0587	DNA-directed DNA polymerase activity
TOL2_RS11400	COG0516	GMP reductase activity
TOL2_RS11400	COG0517	IMP dehydrogenase activity
TOL2_RS11405	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TOL2_RS11410	COG1678	Uncharacterized ACR, COG1678
TOL2_RS11425	COG2226	methyltransferase
TOL2_RS11435	COG1550	Protein conserved in bacteria
TOL2_RS11440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TOL2_RS11460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TOL2_RS11485	COG1131	(ABC) transporter
TOL2_RS11495	COG4969	Belongs to the N-Me-Phe pilin family
TOL2_RS11570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TOL2_RS11585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TOL2_RS11600	COG1373	ATPase (AAA superfamily
TOL2_RS11635	COG0670	Belongs to the BI1 family
TOL2_RS11640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TOL2_RS11650	COG0166	Belongs to the GPI family
TOL2_RS11655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TOL2_RS11660	COG0530	calcium, potassium:sodium antiporter activity
TOL2_RS11665	COG0745	RESPONSE REGULATOR receiver
TOL2_RS11670	COG2204	response regulator
TOL2_RS11690	COG0411	ABC transporter
TOL2_RS11710	COG2204	response regulator
TOL2_RS11720	COG2871	sodium ion transport
TOL2_RS11780	COG2204	response regulator
TOL2_RS11785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TOL2_RS11790	COG0540	Belongs to the ATCase OTCase family
TOL2_RS11810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TOL2_RS11815	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TOL2_RS11830	COG1137	ATPase activity
TOL2_RS11835	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TOL2_RS11845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOL2_RS11850	COG1660	Displays ATPase and GTPase activities
TOL2_RS11860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TOL2_RS11865	COG0149	triose-phosphate isomerase activity
TOL2_RS11880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TOL2_RS11885	COG0535	radical SAM domain protein
TOL2_RS11890	COG0113	porphobilinogen synthase activity
TOL2_RS11895	COG0535	radical SAM domain protein
TOL2_RS11915	COG0552	protein localization to endoplasmic reticulum
TOL2_RS11925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TOL2_RS11930	COG0813	purine-nucleoside phosphorylase activity
TOL2_RS11940	COG0751	glycine-tRNA ligase activity
TOL2_RS11945	COG0752	glycyl-tRNA synthetase alpha subunit
TOL2_RS11955	COG1381	Involved in DNA repair and RecF pathway recombination
TOL2_RS11960	COG2239	Acts as a magnesium transporter
TOL2_RS11965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOL2_RS11980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TOL2_RS11995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TOL2_RS12000	COG4166	transmembrane transport
TOL2_RS12005	COG0444	Belongs to the ABC transporter superfamily
TOL2_RS12010	COG1278	Cold shock
TOL2_RS12015	COG4608	Belongs to the ABC transporter superfamily
TOL2_RS12025	COG3409	Peptidoglycan-binding domain 1 protein
TOL2_RS12025	COG3267	Type II secretory pathway component ExeA
TOL2_RS12050	COG1309	transcriptional regulator
TOL2_RS12055	COG0427	acetyl-CoA hydrolase
TOL2_RS12060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TOL2_RS12065	COG1073	alpha beta
TOL2_RS12070	COG1546	Belongs to the CinA family
TOL2_RS12070	COG1058	Belongs to the CinA family
TOL2_RS12075	COG1032	radical SAM domain protein
TOL2_RS12080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOL2_RS12095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TOL2_RS12100	COG0512	Glutamine amidotransferase of anthranilate synthase
TOL2_RS12100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOL2_RS12105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOL2_RS12110	COG0134	indole-3-glycerol-phosphate synthase activity
TOL2_RS12115	COG0135	phosphoribosylanthranilate isomerase activity
TOL2_RS12120	COG3360	Dodecin
TOL2_RS12130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TOL2_RS12155	COG0728	peptidoglycan biosynthetic process
TOL2_RS12160	COG0268	Binds directly to 16S ribosomal RNA
TOL2_RS12170	COG0495	leucyl-tRNA aminoacylation
TOL2_RS12200	COG0489	protein tyrosine kinase activity
TOL2_RS12225	COG4964	Belongs to the GSP D family
TOL2_RS12265	COG0360	Binds together with S18 to 16S ribosomal RNA
TOL2_RS12270	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TOL2_RS12280	COG0359	binds to the 23S rRNA
TOL2_RS12285	COG0305	Participates in initiation and elongation during chromosome replication
TOL2_RS12295	COG0277	FAD linked oxidase domain protein
TOL2_RS12300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TOL2_RS12305	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TOL2_RS12310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TOL2_RS12320	COG0725	ABC transporter, periplasmic molybdate-binding protein
TOL2_RS12330	COG3842	ATPase activity
TOL2_RS12405	COG0726	polysaccharide deacetylase
TOL2_RS12425	COG0726	polysaccharide deacetylase
TOL2_RS12435	COG0438	transferase activity, transferring glycosyl groups
TOL2_RS12475	COG0726	polysaccharide deacetylase
TOL2_RS12480	COG0367	asparagine synthase
TOL2_RS12485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TOL2_RS12490	COG1215	transferase activity, transferring glycosyl groups
TOL2_RS12495	COG0438	transferase activity, transferring glycosyl groups
TOL2_RS12495	COG0297	glycogen (starch) synthase activity
TOL2_RS12530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TOL2_RS12535	COG0489	protein tyrosine kinase activity
TOL2_RS12545	COG0308	aminopeptidase N
TOL2_RS12580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TOL2_RS12595	COG2719	SpoVR family
TOL2_RS12635	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TOL2_RS12650	COG0358	DNA primase activity
TOL2_RS12675	COG0513	Belongs to the DEAD box helicase family
TOL2_RS12695	COG1484	DNA-dependent DNA replication
TOL2_RS12700	COG4584	PFAM Integrase catalytic
TOL2_RS12715	COG3547	Transposase (IS116 IS110 IS902 family)
TOL2_RS12730	COG2204	response regulator
TOL2_RS12750	COG0569	domain protein
TOL2_RS12755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TOL2_RS12760	COG2304	oxidoreductase activity
TOL2_RS12770	COG0745	RESPONSE REGULATOR receiver
TOL2_RS12790	COG0651	ATP synthesis coupled electron transport
TOL2_RS12800	COG0651	ATP synthesis coupled electron transport
TOL2_RS12805	COG0651	ATP synthesis coupled electron transport
TOL2_RS12810	COG1006	Multisubunit Na H antiporter MnhC subunit
TOL2_RS12825	COG1320	monovalent cation:proton antiporter activity
TOL2_RS12840	COG2204	response regulator
TOL2_RS12850	COG0745	RESPONSE REGULATOR receiver
TOL2_RS12855	COG2204	response regulator
TOL2_RS12860	COG4191	Histidine kinase
TOL2_RS12875	COG4372	Transposase
TOL2_RS12880	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS12900	COG4585	Histidine kinase
TOL2_RS12910	COG1100	Small GTP-binding protein
TOL2_RS12935	COG0457	Tetratricopeptide repeat
TOL2_RS12940	COG0101	tRNA pseudouridine synthase activity
TOL2_RS12975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TOL2_RS12980	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
TOL2_RS12985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TOL2_RS12985	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TOL2_RS13015	COG2920	part of a sulfur-relay system
TOL2_RS13020	COG1522	sequence-specific DNA binding
TOL2_RS13055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TOL2_RS13095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOL2_RS13115	COG0424	maF-like protein
TOL2_RS13120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TOL2_RS13125	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TOL2_RS13130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TOL2_RS13140	COG0488	(ABC) transporter
TOL2_RS13175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TOL2_RS13180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TOL2_RS13190	COG0165	Argininosuccinate lyase
TOL2_RS13195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TOL2_RS13200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TOL2_RS13205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TOL2_RS13210	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TOL2_RS13215	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TOL2_RS13220	COG4974	Belongs to the 'phage' integrase family
TOL2_RS13235	COG0488	(ABC) transporter
TOL2_RS13270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TOL2_RS13285	COG0598	Magnesium transport protein CorA
TOL2_RS13290	COG0058	SHG alpha-glucan phosphorylase activity
TOL2_RS13300	COG1830	Aldolase
TOL2_RS13305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TOL2_RS13325	COG0537	adenosine 5'-monophosphoramidase activity
TOL2_RS13335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TOL2_RS13350	COG0840	transmembrane signaling receptor activity
TOL2_RS13360	COG0840	transmembrane signaling receptor activity
TOL2_RS13375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TOL2_RS13380	COG0596	Alpha beta hydrolase
TOL2_RS13390	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS13395	COG0617	tRNA 3'-terminal CCA addition
TOL2_RS13395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TOL2_RS13395	COG3620	sequence-specific DNA binding
TOL2_RS13405	COG2900	Belongs to the SlyX family
TOL2_RS13410	COG1674	ftsk spoiiie
TOL2_RS13430	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TOL2_RS13430	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TOL2_RS13445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TOL2_RS13450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TOL2_RS13465	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TOL2_RS13475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TOL2_RS13480	COG0281	malic enzyme
TOL2_RS13485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TOL2_RS13490	COG4953	penicillin-binding protein 1C
TOL2_RS13495	COG3077	Addiction module antitoxin, RelB DinJ family
TOL2_RS13520	COG2373	Large extracellular alpha-helical protein
TOL2_RS13640	COG0515	serine threonine protein kinase
TOL2_RS13640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TOL2_RS13690	COG4067	protein conserved in archaea
TOL2_RS13690	COG0189	ligase activity
TOL2_RS13700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOL2_RS13720	COG1392	Phosphate transport regulator
TOL2_RS13725	COG0306	phosphate transporter
TOL2_RS13730	COG1067	ATP-dependent peptidase activity
TOL2_RS13735	COG0045	succinate-CoA ligase (ADP-forming) activity
TOL2_RS13735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TOL2_RS13735	COG0045	succinate-CoA ligase (ADP-forming) activity
TOL2_RS13735	COG1042	CoA-binding domain protein
TOL2_RS13735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TOL2_RS13735	COG1042	CoA-binding domain protein
TOL2_RS13750	COG0531	amino acid
TOL2_RS13755	COG5002	protein histidine kinase activity
TOL2_RS13770	COG0745	RESPONSE REGULATOR receiver
TOL2_RS13790	COG1233	COG1233 Phytoene dehydrogenase and related
TOL2_RS13815	COG4166	transmembrane transport
TOL2_RS13820	COG4174	ABC transporter (Permease)
TOL2_RS13825	COG4239	(ABC) transporter, permease
TOL2_RS13830	COG4172	Belongs to the ABC transporter superfamily
TOL2_RS13850	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TOL2_RS13855	COG0210	DNA helicase
TOL2_RS13860	COG4974	Belongs to the 'phage' integrase family
TOL2_RS13865	COG4974	Belongs to the 'phage' integrase family
TOL2_RS13870	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TOL2_RS13885	COG3344	reverse transcriptase
TOL2_RS13895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TOL2_RS13910	COG4974	Belongs to the 'phage' integrase family
TOL2_RS13915	COG4974	Belongs to the 'phage' integrase family
TOL2_RS13920	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TOL2_RS14025	COG3344	reverse transcriptase
TOL2_RS14040	COG0517	IMP dehydrogenase activity
TOL2_RS14045	COG4974	Belongs to the 'phage' integrase family
TOL2_RS14055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TOL2_RS14070	COG0517	IMP dehydrogenase activity
TOL2_RS14085	COG3344	reverse transcriptase
TOL2_RS14100	COG1484	DNA-dependent DNA replication
TOL2_RS14105	COG4584	PFAM Integrase catalytic
TOL2_RS14140	COG3604	Transcriptional regulator
TOL2_RS14160	COG0471	metal ion transport
TOL2_RS14160	COG3273	potassium ion transport
TOL2_RS14165	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TOL2_RS14170	COG0513	Belongs to the DEAD box helicase family
TOL2_RS14175	COG1162	GTPase activity
TOL2_RS14180	COG3279	Response regulator of the LytR AlgR family
TOL2_RS14185	COG3275	phosphorelay sensor kinase activity
TOL2_RS14260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TOL2_RS14265	COG0798	PFAM Bile acid sodium symporter
TOL2_RS14285	COG1136	(ABC) transporter
TOL2_RS14310	COG1231	oxidoreductase activity
TOL2_RS14325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TOL2_RS14330	COG4771	TonB-dependent receptor
TOL2_RS14380	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS14405	COG1881	PFAM PEBP family protein
TOL2_RS14420	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS14455	COG3344	reverse transcriptase
TOL2_RS14460	COG0583	DNA-binding transcription factor activity
TOL2_RS14505	COG1881	PFAM PEBP family protein
TOL2_RS14520	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS14555	COG3344	reverse transcriptase
TOL2_RS14560	COG0583	DNA-binding transcription factor activity
TOL2_RS14595	COG1881	PFAM PEBP family protein
TOL2_RS14610	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS14645	COG3344	reverse transcriptase
TOL2_RS14650	COG0583	DNA-binding transcription factor activity
TOL2_RS14705	COG1881	PFAM PEBP family protein
TOL2_RS14720	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS14755	COG3344	reverse transcriptase
TOL2_RS14760	COG0583	DNA-binding transcription factor activity
TOL2_RS14805	COG1881	PFAM PEBP family protein
TOL2_RS14820	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS14855	COG3344	reverse transcriptase
TOL2_RS14860	COG0583	DNA-binding transcription factor activity
TOL2_RS14900	COG0840	transmembrane signaling receptor activity
TOL2_RS14915	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS14930	COG4372	Transposase
TOL2_RS14935	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS14955	COG0549	Belongs to the carbamate kinase family
TOL2_RS14965	COG1253	flavin adenine dinucleotide binding
TOL2_RS14970	COG0517	IMP dehydrogenase activity
TOL2_RS15010	COG1396	sequence-specific DNA binding
TOL2_RS15015	COG3550	peptidyl-serine autophosphorylation
TOL2_RS15025	COG4974	Belongs to the 'phage' integrase family
TOL2_RS15060	COG3852	Histidine kinase
TOL2_RS15075	COG1454	alcohol dehydrogenase
TOL2_RS15080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TOL2_RS15085	COG1181	Belongs to the D-alanine--D-alanine ligase family
TOL2_RS15140	COG0039	L-malate dehydrogenase activity
TOL2_RS15145	COG0039	L-malate dehydrogenase activity
TOL2_RS15160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOL2_RS15160	COG0574	Belongs to the PEP-utilizing enzyme family
TOL2_RS15170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TOL2_RS15205	COG5012	cobalamin binding
TOL2_RS15235	COG0446	pyridine nucleotide-disulphide oxidoreductase
TOL2_RS15240	COG0579	oxidoreductase
TOL2_RS15255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TOL2_RS15265	COG0004	ammonium transporteR
TOL2_RS15270	COG0347	Belongs to the P(II) protein family
TOL2_RS15275	COG0644	oxidoreductase
TOL2_RS15295	COG4771	TonB-dependent receptor
TOL2_RS15355	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TOL2_RS15365	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TOL2_RS15370	COG1805	sodium ion transport
TOL2_RS15375	COG4656	Part of a membrane complex involved in electron transport
TOL2_RS15385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TOL2_RS15445	COG3383	formate dehydrogenase (NAD+) activity
TOL2_RS15540	COG5002	protein histidine kinase activity
TOL2_RS15545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TOL2_RS15550	COG0483	inositol monophosphate 1-phosphatase activity
TOL2_RS15565	COG0793	Belongs to the peptidase S41A family
TOL2_RS15570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOL2_RS15580	COG2137	regulation of response to DNA damage stimulus
TOL2_RS15585	COG0252	asparaginase activity
TOL2_RS15595	COG0612	Peptidase, M16
TOL2_RS15600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOL2_RS15610	COG2204	response regulator
TOL2_RS15620	COG0835	chemotaxis
TOL2_RS15635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TOL2_RS15705	COG2204	response regulator
TOL2_RS15710	COG5002	protein histidine kinase activity
TOL2_RS15730	COG2204	response regulator
TOL2_RS15755	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TOL2_RS15765	COG4895	conserved protein (DUF2196)
TOL2_RS15820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOL2_RS15825	COG1013	pyruvate-flavodoxin oxidoreductase activity
TOL2_RS15830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TOL2_RS15830	COG0674	pyruvate-flavodoxin oxidoreductase activity
TOL2_RS15835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOL2_RS15840	COG0493	'glutamate synthase
TOL2_RS15850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TOL2_RS15865	COG4239	(ABC) transporter, permease
TOL2_RS15870	COG4174	ABC transporter (Permease)
TOL2_RS15875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TOL2_RS15880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TOL2_RS15885	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TOL2_RS15895	COG2195	Cleaves the N-terminal amino acid of tripeptides
TOL2_RS15905	COG5002	protein histidine kinase activity
TOL2_RS15915	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TOL2_RS15915	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TOL2_RS15920	COG0280	phosphate acetyltransferase
TOL2_RS15920	COG0281	malic enzyme
TOL2_RS15925	COG0471	metal ion transport
TOL2_RS15930	COG4191	Histidine kinase
TOL2_RS15935	COG2204	response regulator
TOL2_RS15990	COG1837	Belongs to the UPF0109 family
TOL2_RS16020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TOL2_RS16025	COG0739	heme binding
TOL2_RS16030	COG0653	protein targeting
TOL2_RS16035	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TOL2_RS16045	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TOL2_RS16070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TOL2_RS16090	COG3885	ferrous iron binding
TOL2_RS16090	COG2078	PFAM AMMECR1 domain protein
TOL2_RS16095	COG0686	Belongs to the AlaDH PNT family
TOL2_RS16115	COG0501	Belongs to the peptidase M48B family
TOL2_RS16145	COG0590	tRNA wobble adenosine to inosine editing
TOL2_RS16150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TOL2_RS16225	COG1484	DNA-dependent DNA replication
TOL2_RS16230	COG4584	PFAM Integrase catalytic
TOL2_RS16285	COG0616	signal peptide processing
TOL2_RS16310	COG3344	reverse transcriptase
TOL2_RS16330	COG3657	addiction module killer protein
TOL2_RS16340	COG3617	BRO family, N-terminal domain
TOL2_RS16450	COG3706	GGDEF domain
TOL2_RS16465	COG3344	reverse transcriptase
TOL2_RS16470	COG1280	lysine exporter protein (LysE YggA)
TOL2_RS16475	COG3344	reverse transcriptase
TOL2_RS16485	COG4974	Belongs to the 'phage' integrase family
TOL2_RS16490	COG0517	IMP dehydrogenase activity
TOL2_RS16505	COG3344	reverse transcriptase
TOL2_RS16545	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS16550	COG4372	Transposase
TOL2_RS16565	COG4372	Transposase
TOL2_RS16570	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS16585	COG3344	reverse transcriptase
TOL2_RS16590	COG3093	addiction module antidote protein HigA
TOL2_RS16675	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TOL2_RS16680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TOL2_RS16685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TOL2_RS16690	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TOL2_RS16700	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TOL2_RS16715	COG5016	pyruvate
TOL2_RS16715	COG0511	ligase activity, forming carbon-carbon bonds
TOL2_RS16725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TOL2_RS16750	COG0463	Glycosyl transferase, family 2
TOL2_RS16750	COG1216	Glycosyl transferase, family 2
TOL2_RS16760	COG0674	pyruvate-flavodoxin oxidoreductase activity
TOL2_RS16760	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TOL2_RS16765	COG1013	pyruvate-flavodoxin oxidoreductase activity
TOL2_RS16780	COG2204	response regulator
TOL2_RS16785	COG4191	Histidine kinase
TOL2_RS16790	COG0616	signal peptide processing
TOL2_RS16795	COG2183	response to ionizing radiation
TOL2_RS16795	COG0539	negative regulation of cytoplasmic translation
TOL2_RS16800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TOL2_RS16805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TOL2_RS16810	COG3876	Protein conserved in bacteria
TOL2_RS16820	COG2937	Belongs to the GPAT DAPAT family
TOL2_RS16825	COG1213	nucleotidyl transferase
TOL2_RS16830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TOL2_RS16835	COG0484	heat shock protein binding
TOL2_RS16850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TOL2_RS16865	COG2176	DNA-directed DNA polymerase activity
TOL2_RS16865	COG5002	protein histidine kinase activity
TOL2_RS16890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TOL2_RS16905	COG0728	peptidoglycan biosynthetic process
TOL2_RS16910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TOL2_RS16915	COG2226	methyltransferase
TOL2_RS16930	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS16935	COG4372	Transposase
TOL2_RS16960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOL2_RS16965	COG1120	ATPase activity
TOL2_RS17045	COG2200	EAL domain
TOL2_RS17045	COG2202	Pas domain
TOL2_RS17045	COG2199	diguanylate cyclase activity
TOL2_RS17050	COG3624	Phosphonate C-P lyase system protein PhnG
TOL2_RS17060	COG3626	phosphonate metabolism
TOL2_RS17065	COG3627	carbon phosphorus lyase activity
TOL2_RS17070	COG4107	phosphonate C-P lyase system protein PhnK
TOL2_RS17075	COG4778	phosphonate C-P lyase system protein PhnL
TOL2_RS17080	COG3454	Phosphonate metabolism
TOL2_RS17085	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TOL2_RS17095	COG3639	organic phosphonate transmembrane transporter activity
TOL2_RS17145	COG0704	Plays a role in the regulation of phosphate uptake
TOL2_RS17150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TOL2_RS17165	COG0573	inorganic phosphate transmembrane transporter activity
TOL2_RS17190	COG1396	sequence-specific DNA binding
TOL2_RS17205	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TOL2_RS17210	COG0066	3-isopropylmalate dehydratase activity
TOL2_RS17285	COG0646	methionine synthase
TOL2_RS17285	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TOL2_RS17300	COG0070	glutamate synthase
TOL2_RS17300	COG0067	glutamate synthase
TOL2_RS17300	COG0069	glutamate synthase activity
TOL2_RS17335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TOL2_RS17340	COG0573	inorganic phosphate transmembrane transporter activity
TOL2_RS17345	COG0581	inorganic phosphate transmembrane transporter activity
TOL2_RS17350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TOL2_RS17355	COG0704	Plays a role in the regulation of phosphate uptake
TOL2_RS17380	COG1882	Formate acetyltransferase
TOL2_RS17420	COG2204	response regulator
TOL2_RS17455	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TOL2_RS17460	COG2086	electron transfer activity
TOL2_RS17465	COG1960	acyl-CoA dehydrogenase activity
TOL2_RS17470	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TOL2_RS17475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TOL2_RS17480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TOL2_RS17495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOL2_RS17510	COG1918	ferrous iron import across plasma membrane
TOL2_RS17510	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOL2_RS17535	COG0811	peptide transport
TOL2_RS17540	COG0811	peptide transport
TOL2_RS17545	COG0848	biopolymer transport protein
TOL2_RS17565	COG3550	peptidyl-serine autophosphorylation
TOL2_RS17575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOL2_RS17595	COG4771	TonB-dependent receptor
TOL2_RS17610	COG2890	protein-(glutamine-N5) methyltransferase activity
TOL2_RS17625	COG4771	TonB-dependent receptor
TOL2_RS17640	COG0716	FMN binding
TOL2_RS17650	COG4771	TonB-dependent receptor
TOL2_RS17660	COG4771	TonB-dependent receptor
TOL2_RS17665	COG4771	TonB-dependent receptor
TOL2_RS17695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TOL2_RS17715	COG0443	Heat shock 70 kDa protein
TOL2_RS17740	COG3141	response to X-ray
TOL2_RS17760	COG0493	'glutamate synthase
TOL2_RS17775	COG2814	Major facilitator Superfamily
TOL2_RS17790	COG1960	acyl-CoA dehydrogenase activity
TOL2_RS17805	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TOL2_RS17820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TOL2_RS17830	COG0745	RESPONSE REGULATOR receiver
TOL2_RS17840	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TOL2_RS17845	COG0482	sulfurtransferase activity
TOL2_RS17855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TOL2_RS17860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TOL2_RS17865	COG0228	four-way junction DNA binding
TOL2_RS17870	COG1837	Belongs to the UPF0109 family
TOL2_RS17875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TOL2_RS17880	COG0336	Belongs to the RNA methyltransferase TrmD family
TOL2_RS17885	COG4752	Belongs to the RNA methyltransferase TrmD family
TOL2_RS17885	COG0336	Belongs to the RNA methyltransferase TrmD family
TOL2_RS17890	COG0335	large ribosomal subunit rRNA binding
TOL2_RS17895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TOL2_RS17900	COG0792	nuclease activity
TOL2_RS17905	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TOL2_RS17915	COG2046	Belongs to the sulfate adenylyltransferase family
TOL2_RS17935	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TOL2_RS17940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOL2_RS17945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TOL2_RS17950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TOL2_RS17955	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOL2_RS17955	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOL2_RS17960	COG0307	riboflavin synthase, alpha
TOL2_RS17965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOL2_RS17965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOL2_RS17970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TOL2_RS17980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TOL2_RS17985	COG0698	ribose 5-phosphate isomerase
TOL2_RS17990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TOL2_RS17995	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TOL2_RS18005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOL2_RS18020	COG0375	protein maturation
TOL2_RS18025	COG0343	queuine tRNA-ribosyltransferase activity
TOL2_RS18040	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TOL2_RS18065	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TOL2_RS18075	COG0154	amidase activity
TOL2_RS18080	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TOL2_RS18090	COG0018	arginyl-trna synthetase
TOL2_RS18100	COG4772	TonB-dependent receptor
TOL2_RS18110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOL2_RS18115	COG1120	ATPase activity
TOL2_RS18150	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
TOL2_RS18180	COG3547	Transposase (IS116 IS110 IS902 family)
TOL2_RS18215	COG0437	4 iron, 4 sulfur cluster binding
TOL2_RS18235	COG4822	anaerobic cobalamin biosynthetic process
TOL2_RS18245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TOL2_RS18250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOL2_RS18255	COG1120	ATPase activity
TOL2_RS18270	COG0811	peptide transport
TOL2_RS18275	COG0811	peptide transport
TOL2_RS18280	COG0848	biopolymer transport protein
TOL2_RS18300	COG4206	TonB-dependent receptor
TOL2_RS18340	COG0484	heat shock protein binding
TOL2_RS18365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TOL2_RS18365	COG2070	2-Nitropropane dioxygenase
TOL2_RS18370	COG4974	Belongs to the 'phage' integrase family
TOL2_RS18375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TOL2_RS18395	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TOL2_RS18400	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TOL2_RS18405	COG0402	S-adenosylhomocysteine deaminase activity
TOL2_RS18410	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TOL2_RS18420	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TOL2_RS18425	COG0203	ribosomal protein L17
TOL2_RS18430	COG0202	RNA polymerase activity
TOL2_RS18435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TOL2_RS18440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TOL2_RS18445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TOL2_RS18450	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TOL2_RS18455	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TOL2_RS18465	COG0200	Binds to the 23S rRNA
TOL2_RS18470	COG1841	ribosomal large subunit assembly
TOL2_RS18480	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TOL2_RS18485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TOL2_RS18490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TOL2_RS18495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TOL2_RS18500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TOL2_RS18505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TOL2_RS18510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TOL2_RS18515	COG0255	Belongs to the universal ribosomal protein uL29 family
TOL2_RS18520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TOL2_RS18525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TOL2_RS18530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TOL2_RS18535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TOL2_RS18540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TOL2_RS18545	COG0089	rRNA binding
TOL2_RS18550	COG0088	Forms part of the polypeptide exit tunnel
TOL2_RS18555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TOL2_RS18560	COG0051	transcription antitermination factor activity, RNA binding
TOL2_RS18565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TOL2_RS18570	COG0049	tRNA binding
TOL2_RS18575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TOL2_RS18580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TOL2_RS18585	COG0085	RNA polymerase activity
TOL2_RS18590	COG0222	ribosome binding
TOL2_RS18595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TOL2_RS18600	COG0081	regulation of translation
TOL2_RS18605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TOL2_RS18615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TOL2_RS18625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TOL2_RS18630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TOL2_RS18665	COG0826	peptidase U32
TOL2_RS18670	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TOL2_RS18685	COG0126	phosphoglycerate kinase activity
TOL2_RS18695	COG2003	Belongs to the UPF0758 family
TOL2_RS18705	COG0628	permease
TOL2_RS18710	COG0183	Belongs to the thiolase family
TOL2_RS18725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TOL2_RS18730	COG1160	GTP binding
TOL2_RS18755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TOL2_RS18770	COG3958	Transketolase
TOL2_RS18775	COG3959	Transketolase, thiamine diphosphate binding domain
TOL2_RS18785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TOL2_RS18820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TOL2_RS18830	COG1088	dTDP-glucose 4,6-dehydratase activity
TOL2_RS18845	COG2226	methyltransferase
TOL2_RS18850	COG0463	Glycosyl transferase, family 2
TOL2_RS18870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TOL2_RS18875	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TOL2_RS18890	COG2089	acid synthase
TOL2_RS18895	COG1083	cytidylyl-transferase
TOL2_RS18910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TOL2_RS18910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TOL2_RS18915	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TOL2_RS18935	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TOL2_RS18940	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TOL2_RS18960	COG1705	Flagellar rod assembly protein muramidase FlgJ
TOL2_RS18960	COG3951	Flagellar rod assembly protein muramidase FlgJ
TOL2_RS18965	COG1706	bacterial-type flagellum-dependent cell motility
TOL2_RS18970	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TOL2_RS18980	COG4786	Flagellar basal body rod
TOL2_RS18985	COG4786	Flagellar basal body rod
TOL2_RS18995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TOL2_RS19030	COG1419	protein localization to endoplasmic reticulum
TOL2_RS19035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TOL2_RS19040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TOL2_RS19045	COG1684	flagellar biosynthetic protein fliR
TOL2_RS19050	COG1987	bacterial-type flagellum assembly
TOL2_RS19055	COG1338	Plays a role in the flagellum-specific transport system
TOL2_RS19080	COG1749	Flagellar hook protein flgE
TOL2_RS19115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TOL2_RS19120	COG1766	The M ring may be actively involved in energy transduction
TOL2_RS19130	COG1558	bacterial-type flagellum-dependent cell motility
TOL2_RS19140	COG2204	response regulator
TOL2_RS19160	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TOL2_RS19160	COG2199	diguanylate cyclase activity
TOL2_RS19175	COG1324	tolerance protein
TOL2_RS19180	COG0655	NAD(P)H dehydrogenase (quinone) activity
TOL2_RS19185	COG0427	acetyl-CoA hydrolase
TOL2_RS19190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TOL2_RS19200	COG0776	regulation of translation
TOL2_RS19205	COG2814	Major facilitator Superfamily
TOL2_RS19220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TOL2_RS19240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TOL2_RS19245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TOL2_RS19250	COG0436	Aminotransferase
TOL2_RS19255	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TOL2_RS19260	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TOL2_RS19270	COG3852	Histidine kinase
TOL2_RS19275	COG2204	response regulator
TOL2_RS19285	COG2205	protein histidine kinase activity
TOL2_RS19305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TOL2_RS19315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TOL2_RS19365	COG0204	Acyl-transferase
TOL2_RS19375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TOL2_RS19380	COG1475	DNA binding
TOL2_RS19385	COG1192	Involved in chromosome partitioning
TOL2_RS19400	COG1643	Atp-dependent helicase
TOL2_RS19405	COG0785	Cytochrome C biogenesis protein
TOL2_RS19415	COG0587	DNA-directed DNA polymerase activity
TOL2_RS19420	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TOL2_RS19435	COG2885	chlorophyll binding
TOL2_RS19445	COG3944	biosynthesis protein
TOL2_RS19465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TOL2_RS19480	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS19485	COG4372	Transposase
TOL2_RS19545	COG1045	serine acetyltransferase
TOL2_RS19575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TOL2_RS19585	COG1959	2 iron, 2 sulfur cluster binding
TOL2_RS19590	COG4191	Histidine kinase
TOL2_RS19605	COG0247	lactate metabolic process
TOL2_RS19610	COG2181	nitrate reductase activity
TOL2_RS19615	COG5557	Pfam Polysulphide reductase, NrfD
TOL2_RS19620	COG3064	Membrane
TOL2_RS19620	COG0437	4 iron, 4 sulfur cluster binding
TOL2_RS19625	COG0484	heat shock protein binding
TOL2_RS19630	COG0543	2 iron, 2 sulfur cluster binding
TOL2_RS19635	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TOL2_RS19635	COG0493	'glutamate synthase
TOL2_RS19650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TOL2_RS19670	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
TOL2_RS19675	COG2030	dehydratase
TOL2_RS19680	COG0024	Methionine aminopeptidase
TOL2_RS19735	COG0720	synthase
TOL2_RS19740	COG0484	heat shock protein binding
TOL2_RS19745	COG2226	methyltransferase
TOL2_RS19750	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TOL2_RS19770	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS19775	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TOL2_RS19780	COG0084	hydrolase, TatD family'
TOL2_RS19790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TOL2_RS19835	COG0604	alcohol dehydrogenase
TOL2_RS19855	COG0446	pyridine nucleotide-disulphide oxidoreductase
TOL2_RS19860	COG1283	sodium-dependent phosphate transmembrane transporter activity
TOL2_RS19875	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TOL2_RS19880	COG4804	nuclease activity
TOL2_RS19885	COG0732	type I restriction modification DNA specificity domain
TOL2_RS19890	COG4804	nuclease activity
TOL2_RS19895	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TOL2_RS19910	COG4978	Transcriptional regulator
TOL2_RS19910	COG0789	Transcriptional regulator
TOL2_RS19920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOL2_RS19930	COG4149	molybdate abc transporter
TOL2_RS19935	COG0725	ABC transporter, periplasmic molybdate-binding protein
TOL2_RS19950	COG1363	Peptidase, m42
TOL2_RS19965	COG0445	tRNA wobble uridine modification
TOL2_RS19970	COG0484	heat shock protein binding
TOL2_RS19975	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TOL2_RS20000	COG0602	queuosine metabolic process
TOL2_RS20005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TOL2_RS20010	COG4206	TonB-dependent receptor
TOL2_RS20025	COG3830	Belongs to the UPF0237 family
TOL2_RS20025	COG0560	Phosphoserine phosphatase
TOL2_RS20035	COG0617	tRNA 3'-terminal CCA addition
TOL2_RS20050	COG2226	methyltransferase
TOL2_RS20055	COG2894	cell division
TOL2_RS20060	COG1067	ATP-dependent peptidase activity
TOL2_RS20090	COG1047	Peptidyl-prolyl cis-trans
TOL2_RS20115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TOL2_RS20135	COG2183	response to ionizing radiation
TOL2_RS20140	COG1971	Probably functions as a manganese efflux pump
TOL2_RS20175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL2_RS20200	COG1213	nucleotidyl transferase
TOL2_RS20205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TOL2_RS20235	COG3437	response regulator, receiver
TOL2_RS20250	COG2203	Gaf domain
TOL2_RS20250	COG2199	diguanylate cyclase activity
TOL2_RS20255	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TOL2_RS20260	COG3706	GGDEF domain
TOL2_RS20275	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TOL2_RS20280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOL2_RS20285	COG1151	hydroxylamine reductase activity
TOL2_RS20290	COG0437	4 iron, 4 sulfur cluster binding
TOL2_RS20295	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS20305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TOL2_RS20310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOL2_RS20315	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TOL2_RS20325	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TOL2_RS20325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TOL2_RS20330	COG0784	Response regulator, receiver
TOL2_RS20330	COG4191	Histidine kinase
TOL2_RS20340	COG1024	Enoyl-CoA hydratase
TOL2_RS20345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TOL2_RS20350	COG0511	ligase activity, forming carbon-carbon bonds
TOL2_RS20375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TOL2_RS20380	COG2264	protein methyltransferase activity
TOL2_RS20410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TOL2_RS20465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TOL2_RS20485	COG0644	oxidoreductase
TOL2_RS20490	COG1032	radical SAM domain protein
TOL2_RS20500	COG1028	Short-chain dehydrogenase reductase Sdr
TOL2_RS20510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TOL2_RS20520	COG1032	radical SAM domain protein
TOL2_RS20530	COG2264	protein methyltransferase activity
TOL2_RS20535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TOL2_RS20540	COG1127	ABC transporter
TOL2_RS20555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TOL2_RS20565	COG2084	Dehydrogenase
TOL2_RS20570	COG2358	TRAP transporter, solute receptor (TAXI family
TOL2_RS20590	COG2197	response regulator
TOL2_RS20595	COG4585	Histidine kinase
TOL2_RS20605	COG0500	methyltransferase
TOL2_RS20610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOL2_RS20635	COG0011	TIGRFAM Protein of
TOL2_RS20645	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TOL2_RS20650	COG1739	Uncharacterized protein family UPF0029
TOL2_RS20660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TOL2_RS20665	COG0066	3-isopropylmalate dehydratase activity
TOL2_RS20670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TOL2_RS20675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TOL2_RS20675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TOL2_RS20685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TOL2_RS20690	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TOL2_RS20705	COG0497	DNA recombination
TOL2_RS20720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TOL2_RS20735	COG0484	heat shock protein binding
TOL2_RS20745	COG0747	negative chemotaxis
TOL2_RS20755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TOL2_RS20770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TOL2_RS20775	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TOL2_RS20790	COG0850	regulation of cytokinetic process
TOL2_RS20795	COG2894	cell division
TOL2_RS20800	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TOL2_RS20805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TOL2_RS20805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TOL2_RS20835	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TOL2_RS20860	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TOL2_RS20870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TOL2_RS20875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TOL2_RS20885	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TOL2_RS20920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TOL2_RS20945	COG3028	Belongs to the UPF0307 family
TOL2_RS20965	COG0701	Predicted permease
TOL2_RS20995	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TOL2_RS21010	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TOL2_RS21020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TOL2_RS21045	COG0811	peptide transport
TOL2_RS21050	COG0848	biopolymer transport protein
TOL2_RS21065	COG4191	Histidine kinase
TOL2_RS21070	COG2204	response regulator
TOL2_RS21095	COG1136	(ABC) transporter
TOL2_RS21120	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TOL2_RS21125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TOL2_RS21135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TOL2_RS21140	COG0124	histidyl-tRNA synthetase
TOL2_RS21145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TOL2_RS21175	COG2205	protein histidine kinase activity
TOL2_RS21180	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
TOL2_RS21185	COG0731	radical SAM domain protein
TOL2_RS21185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TOL2_RS21190	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TOL2_RS21195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TOL2_RS21220	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TOL2_RS21225	COG0442	prolyl-tRNA aminoacylation
TOL2_RS21235	COG0574	Belongs to the PEP-utilizing enzyme family
TOL2_RS21235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOL2_RS21240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TOL2_RS21250	COG3706	GGDEF domain
TOL2_RS21255	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TOL2_RS21270	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TOL2_RS21275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TOL2_RS21290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOL2_RS21295	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TOL2_RS21305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TOL2_RS21375	COG0484	heat shock protein binding
TOL2_RS21380	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TOL2_RS21405	COG0101	tRNA pseudouridine synthase activity
TOL2_RS21410	COG1702	phosphate starvation-inducible protein PhoH
TOL2_RS21415	COG0577	efflux transmembrane transporter activity
TOL2_RS21415	COG1136	(ABC) transporter
TOL2_RS21420	COG1136	(ABC) transporter
TOL2_RS21460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TOL2_RS21470	COG0419	ATPase involved in DNA repair
TOL2_RS21475	COG0420	3'-5' exonuclease activity
TOL2_RS21490	COG0745	RESPONSE REGULATOR receiver
TOL2_RS21515	COG2205	protein histidine kinase activity
TOL2_RS21515	COG0784	Response regulator, receiver
TOL2_RS21530	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TOL2_RS21535	COG1842	Phage shock protein A
TOL2_RS21555	COG0596	Alpha beta hydrolase
TOL2_RS21560	COG3012	SEC-C Motif Domain Protein
TOL2_RS21585	COG0443	Heat shock 70 kDa protein
TOL2_RS21605	COG1683	Conserved Protein
TOL2_RS21610	COG1960	acyl-CoA dehydrogenase activity
TOL2_RS21650	COG1278	Cold shock
TOL2_RS21655	COG0398	Pfam SNARE associated Golgi protein
TOL2_RS21665	COG0398	Pfam SNARE associated Golgi protein
TOL2_RS21680	COG0739	heme binding
TOL2_RS21685	COG0318	PFAM AMP-dependent synthetase and ligase
TOL2_RS21690	COG0493	'glutamate synthase
TOL2_RS21695	COG0674	pyruvate-flavodoxin oxidoreductase activity
TOL2_RS21725	COG1509	lysine 2,3-aminomutase activity
TOL2_RS21755	COG0107	imidazoleglycerol-phosphate synthase activity
TOL2_RS21780	COG0594	ribonuclease P activity
TOL2_RS21785	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TOL2_RS21790	COG0706	membrane insertase activity
TOL2_RS21795	COG1847	R3H domain protein
TOL2_RS21800	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TOL2_RS21815	COG2264	protein methyltransferase activity
TOL2_RS21820	COG1525	nuclease
TOL2_RS21835	COG1378	Sugar-specific transcriptional regulator TrmB
TOL2_RS21855	COG2204	response regulator
TOL2_RS21865	COG0840	transmembrane signaling receptor activity
TOL2_RS21885	COG0517	IMP dehydrogenase activity
TOL2_RS21895	COG2188	Transcriptional regulator
TOL2_RS21900	COG0133	tryptophan synthase activity
TOL2_RS21905	COG0159	tryptophan synthase activity
TOL2_RS21940	COG1132	(ABC) transporter
TOL2_RS21945	COG1132	(ABC) transporter
TOL2_RS21970	COG2181	nitrate reductase activity
TOL2_RS21970	COG0247	lactate metabolic process
TOL2_RS21985	COG1309	transcriptional regulator
TOL2_RS21990	COG2414	aldehyde ferredoxin oxidoreductase
TOL2_RS22005	COG2204	response regulator
TOL2_RS22025	COG2409	Drug exporters of the RND superfamily
TOL2_RS22080	COG0437	4 iron, 4 sulfur cluster binding
TOL2_RS22110	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TOL2_RS22110	COG3608	succinylglutamate desuccinylase aspartoacylase
TOL2_RS22115	COG1058	Belongs to the CinA family
TOL2_RS22115	COG1546	Belongs to the CinA family
TOL2_RS22125	COG0303	'Molybdopterin
TOL2_RS22140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TOL2_RS22145	COG1763	Mo-molybdopterin cofactor biosynthetic process
TOL2_RS22185	COG4771	TonB-dependent receptor
TOL2_RS22200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TOL2_RS22205	COG1074	ATP-dependent DNA helicase activity
TOL2_RS22210	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TOL2_RS22215	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TOL2_RS22220	COG1902	pentaerythritol trinitrate reductase activity
TOL2_RS22225	COG4771	TonB-dependent receptor
TOL2_RS22250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOL2_RS22255	COG1120	ATPase activity
TOL2_RS22280	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TOL2_RS22285	COG1131	(ABC) transporter
TOL2_RS22290	COG0842	Transport permease protein
TOL2_RS22310	COG0006	proline dipeptidase activity
TOL2_RS22315	COG0116	Belongs to the methyltransferase superfamily
TOL2_RS22325	COG0604	alcohol dehydrogenase
TOL2_RS22345	COG2181	nitrate reductase activity
TOL2_RS22350	COG0247	lactate metabolic process
TOL2_RS22365	COG5002	protein histidine kinase activity
TOL2_RS22370	COG0745	RESPONSE REGULATOR receiver
TOL2_RS22375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TOL2_RS22380	COG1151	hydroxylamine reductase activity
TOL2_RS22395	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TOL2_RS22405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOL2_RS22435	COG1283	sodium-dependent phosphate transmembrane transporter activity
TOL2_RS22440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOL2_RS22445	COG1522	sequence-specific DNA binding
TOL2_RS22450	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TOL2_RS22530	COG0358	DNA primase activity
TOL2_RS22620	COG0517	IMP dehydrogenase activity
TOL2_RS22625	COG4974	Belongs to the 'phage' integrase family
TOL2_RS22685	COG2951	lytic endotransglycosylase activity
TOL2_RS22695	COG0347	Belongs to the P(II) protein family
TOL2_RS22700	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TOL2_RS22705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOL2_RS22710	COG3604	Transcriptional regulator
TOL2_RS22725	COG2884	Cell division ATP-binding protein ftsE
TOL2_RS22730	COG2177	Part of the ABC transporter FtsEX involved in
TOL2_RS22735	COG4942	peptidase
TOL2_RS22740	COG0793	Belongs to the peptidase S41A family
TOL2_RS22760	COG0513	Belongs to the DEAD box helicase family
TOL2_RS22775	COG0725	ABC transporter, periplasmic molybdate-binding protein
TOL2_RS22780	COG4149	molybdate abc transporter
TOL2_RS22785	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TOL2_RS22795	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TOL2_RS22800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TOL2_RS22805	COG0505	Belongs to the CarA family
TOL2_RS22810	COG0432	Pfam Uncharacterised protein family UPF0047
TOL2_RS22815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TOL2_RS22830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOL2_RS22835	COG0142	geranyltranstransferase activity
TOL2_RS22845	COG2909	trisaccharide binding
TOL2_RS22885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TOL2_RS22895	COG3436	PFAM IS66 Orf2 family protein
TOL2_RS22900	COG4372	Transposase
TOL2_RS22910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TOL2_RS22920	COG4864	UPF0365 protein
TOL2_RS22930	COG1030	water channel activity
TOL2_RS22950	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TOL2_RS22955	COG3842	ATPase activity
TOL2_RS22960	COG0390	transport system, permease component
TOL2_RS22965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TOL2_RS22975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOL2_RS22980	COG1120	ATPase activity
TOL2_RS23020	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TOL2_RS23025	COG1492	cobalamin metabolic process
TOL2_RS23045	COG0303	'Molybdopterin
TOL2_RS23050	COG3383	formate dehydrogenase (NAD+) activity
TOL2_RS23080	COG2181	nitrate reductase activity
TOL2_RS23080	COG0247	lactate metabolic process
TOL2_RS23085	COG0303	'Molybdopterin
TOL2_RS23090	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TOL2_RS23095	COG2414	aldehyde ferredoxin oxidoreductase
TOL2_RS23115	COG1546	Belongs to the CinA family
TOL2_RS23115	COG1058	Belongs to the CinA family
TOL2_RS23120	COG1763	Mo-molybdopterin cofactor biosynthetic process
TOL2_RS23135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TOL2_RS23155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TOL2_RS23165	COG0835	chemotaxis
TOL2_RS23190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TOL2_RS23195	COG1910	domain protein
TOL2_RS23210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TOL2_RS23225	COG2204	response regulator
TOL2_RS23235	COG3064	Membrane
TOL2_RS23235	COG0437	4 iron, 4 sulfur cluster binding
TOL2_RS23240	COG5557	Pfam Polysulphide reductase, NrfD
TOL2_RS23255	COG0840	transmembrane signaling receptor activity
TOL2_RS23265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TOL2_RS23270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TOL2_RS23270	COG2885	chlorophyll binding
TOL2_RS23290	COG3328	transposase activity
TOL2_RS23325	COG0784	Response regulator, receiver
TOL2_RS23325	COG2205	protein histidine kinase activity
TOL2_RS23345	COG0860	N-Acetylmuramoyl-L-alanine amidase
TOL2_RS23360	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TOL2_RS23370	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TOL2_RS23400	COG2198	Histidine kinase
TOL2_RS23400	COG5002	protein histidine kinase activity
TOL2_RS23400	COG0784	Response regulator, receiver
TOL2_RS23410	COG3409	Peptidoglycan-binding domain 1 protein
TOL2_RS23410	COG3267	Type II secretory pathway component ExeA
TOL2_RS23425	COG5002	protein histidine kinase activity
TOL2_RS23425	COG0784	Response regulator, receiver
TOL2_RS23425	COG2205	protein histidine kinase activity
TOL2_RS23430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TOL2_RS23445	COG2207	Transcriptional regulator
TOL2_RS23470	COG2205	protein histidine kinase activity
TOL2_RS23470	COG3437	response regulator, receiver
TOL2_RS23470	COG3850	Histidine kinase
TOL2_RS23470	COG4999	Histidine kinase
TOL2_RS23475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TOL2_RS23475	COG4191	Histidine kinase
TOL2_RS23485	COG4251	negative regulation of phosphorylation
TOL2_RS23495	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TOL2_RS23510	COG3646	Phage regulatory protein
TOL2_RS23540	COG4191	Histidine kinase
TOL2_RS23545	COG4191	Histidine kinase
TOL2_RS23550	COG3850	Histidine kinase
TOL2_RS23555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TOL2_RS23570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TOL2_RS23575	COG0546	phosphoglycolate phosphatase activity
TOL2_RS23580	COG0745	RESPONSE REGULATOR receiver
TOL2_RS23590	COG4191	Histidine kinase
TOL2_RS23620	COG1216	Glycosyl transferase, family 2
TOL2_RS23640	COG0835	chemotaxis
TOL2_RS23640	COG0784	Response regulator, receiver
TOL2_RS23655	COG5002	protein histidine kinase activity
TOL2_RS23660	COG1573	uracil-dna glycosylase
TOL2_RS23665	COG3264	Mechanosensitive ion channel
TOL2_RS23665	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
TOL2_RS23685	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TOL2_RS23700	COG3852	Histidine kinase
TOL2_RS23710	COG0840	transmembrane signaling receptor activity
TOL2_RS23715	COG0840	transmembrane signaling receptor activity
TOL2_RS23720	COG0840	transmembrane signaling receptor activity
TOL2_RS23725	COG0840	transmembrane signaling receptor activity
TOL2_RS23775	COG0484	heat shock protein binding
TOL2_RS23790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TOL2_RS23795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TOL2_RS23800	COG0784	Response regulator, receiver
TOL2_RS23800	COG0643	Histidine kinase
TOL2_RS23800	COG2198	Histidine kinase
TOL2_RS23830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TOL2_RS23850	COG4585	Histidine kinase
TOL2_RS23860	COG2202	Pas domain
TOL2_RS23860	COG2205	protein histidine kinase activity
TOL2_RS23865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TOL2_RS23875	COG3706	GGDEF domain
TOL2_RS23905	COG4191	Histidine kinase
TOL2_RS23905	COG0784	Response regulator, receiver
TOL2_RS23930	COG2207	Transcriptional regulator
TOL2_RS23940	COG0513	Belongs to the DEAD box helicase family
TOL2_RS23950	COG2861	carbohydrate metabolic process
TOL2_RS23955	COG2005	Transcriptional regulator