locus-tag	class	description
UWK_RS00020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
UWK_RS00040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
UWK_RS00045	COG0756	dUTP diphosphatase activity
UWK_RS00050	COG1185	polyribonucleotide nucleotidyltransferase activity
UWK_RS00055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
UWK_RS00060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
UWK_RS00065	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
UWK_RS00070	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
UWK_RS00075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
UWK_RS00075	COG3064	Membrane
UWK_RS00090	COG0779	Required for maturation of 30S ribosomal subunits
UWK_RS00110	COG0799	negative regulation of ribosome biogenesis
UWK_RS00120	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
UWK_RS00125	COG0402	S-adenosylhomocysteine deaminase activity
UWK_RS00130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UWK_RS00135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UWK_RS00165	COG0493	'glutamate synthase
UWK_RS00185	COG0306	phosphate transporter
UWK_RS00200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
UWK_RS00210	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
UWK_RS00215	COG0501	Belongs to the peptidase M48B family
UWK_RS00250	COG0424	maF-like protein
UWK_RS00255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UWK_RS00255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UWK_RS00270	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
UWK_RS00275	COG3852	Histidine kinase
UWK_RS00295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UWK_RS00320	COG3022	response to hydroperoxide
UWK_RS00325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
UWK_RS00330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UWK_RS00335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UWK_RS00340	COG0505	Belongs to the CarA family
UWK_RS00345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
UWK_RS00365	COG0443	Heat shock 70 kDa protein
UWK_RS00375	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
UWK_RS00380	COG0535	radical SAM domain protein
UWK_RS00385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
UWK_RS00395	COG1280	lysine exporter protein (LysE YggA)
UWK_RS00400	COG2814	Major facilitator Superfamily
UWK_RS00410	COG1280	lysine exporter protein (LysE YggA)
UWK_RS00415	COG2951	lytic endotransglycosylase activity
UWK_RS00420	COG0519	Catalyzes the synthesis of GMP from XMP
UWK_RS00440	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
UWK_RS00445	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
UWK_RS00470	COG0683	leucine binding
UWK_RS00505	COG0488	(ABC) transporter
UWK_RS00515	COG0571	ribonuclease III activity
UWK_RS00530	COG1045	serine acetyltransferase
UWK_RS00535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UWK_RS00545	COG1181	Belongs to the D-alanine--D-alanine ligase family
UWK_RS00550	COG1181	Belongs to the D-alanine--D-alanine ligase family
UWK_RS00560	COG2308	Evidence 4 Homologs of previously reported genes of
UWK_RS00605	COG0535	radical SAM domain protein
UWK_RS00620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UWK_RS00625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UWK_RS00630	COG5002	protein histidine kinase activity
UWK_RS00640	COG0463	Glycosyl transferase, family 2
UWK_RS00670	COG1028	Short-chain dehydrogenase reductase Sdr
UWK_RS00675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
UWK_RS00680	COG1032	radical SAM domain protein
UWK_RS00690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UWK_RS00695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UWK_RS00705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
UWK_RS00710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UWK_RS00725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UWK_RS00755	COG3852	Histidine kinase
UWK_RS00770	COG0243	molybdopterin cofactor binding
UWK_RS00775	COG0726	polysaccharide deacetylase
UWK_RS00790	COG2925	Exonuclease
UWK_RS00820	COG1451	nucleotide metabolic process
UWK_RS00830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UWK_RS00905	COG0157	Belongs to the NadC ModD family
UWK_RS00910	COG0525	valine-tRNA ligase activity
UWK_RS00915	COG0232	Belongs to the dGTPase family. Type 2 subfamily
UWK_RS00930	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
UWK_RS00935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
UWK_RS00945	COG0439	Biotin carboxylase
UWK_RS00950	COG0825	malonyl-CoA metabolic process
UWK_RS00975	COG0513	Belongs to the DEAD box helicase family
UWK_RS01005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UWK_RS01015	COG3706	GGDEF domain
UWK_RS01030	COG0070	glutamate synthase
UWK_RS01030	COG0069	glutamate synthase activity
UWK_RS01030	COG0067	glutamate synthase
UWK_RS01035	COG0493	'glutamate synthase
UWK_RS01045	COG0004	ammonium transporteR
UWK_RS01115	COG1530	ribonuclease E activity
UWK_RS01125	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
UWK_RS01135	COG2951	lytic endotransglycosylase activity
UWK_RS01155	COG0791	NLP P60 protein
UWK_RS01165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
UWK_RS01170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UWK_RS01175	COG0710	3-dehydroquinate dehydratase activity
UWK_RS01190	COG0543	2 iron, 2 sulfur cluster binding
UWK_RS01210	COG0437	4 iron, 4 sulfur cluster binding
UWK_RS01235	COG0793	Belongs to the peptidase S41A family
UWK_RS01325	COG1160	GTP binding
UWK_RS01350	COG0840	transmembrane signaling receptor activity
UWK_RS01370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UWK_RS01395	COG1942	4-Oxalocrotonate Tautomerase
UWK_RS01450	COG2081	HI0933 family
UWK_RS01455	COG0544	peptidyl-prolyl cis-trans isomerase activity
UWK_RS01460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UWK_RS01470	COG3123	guanosine phosphorylase activity
UWK_RS01480	COG1234	tRNA 3'-trailer cleavage
UWK_RS01490	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
UWK_RS01505	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
UWK_RS01515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UWK_RS01530	COG3383	formate dehydrogenase (NAD+) activity
UWK_RS01565	COG3706	GGDEF domain
UWK_RS01590	COG0363	glucosamine-6-phosphate deaminase activity
UWK_RS01595	COG0129	dihydroxy-acid dehydratase activity
UWK_RS01600	COG0800	Aldolase
UWK_RS01610	COG0058	SHG alpha-glucan phosphorylase activity
UWK_RS01615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
UWK_RS01620	COG0469	pyruvate kinase activity
UWK_RS01625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UWK_RS01630	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
UWK_RS01635	COG1592	Rubrerythrin
UWK_RS01640	COG1592	Rubrerythrin
UWK_RS01660	COG0004	ammonium transporteR
UWK_RS01670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UWK_RS01695	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
UWK_RS01700	COG0347	Belongs to the P(II) protein family
UWK_RS01705	COG0347	Belongs to the P(II) protein family
UWK_RS01775	COG1433	Dinitrogenase iron-molybdenum cofactor
UWK_RS01775	COG0535	radical SAM domain protein
UWK_RS01780	COG1971	Probably functions as a manganese efflux pump
UWK_RS01785	COG1238	metal cluster binding
UWK_RS01795	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
UWK_RS01830	COG4771	TonB-dependent receptor
UWK_RS01840	COG0513	Belongs to the DEAD box helicase family
UWK_RS01845	COG1278	Cold shock
UWK_RS01850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UWK_RS01865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UWK_RS01875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
UWK_RS01875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UWK_RS01895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
UWK_RS01900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UWK_RS01905	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
UWK_RS01930	COG3681	Belongs to the UPF0597 family
UWK_RS01935	COG0826	peptidase U32
UWK_RS01940	COG0482	sulfurtransferase activity
UWK_RS01945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UWK_RS01950	COG1546	Belongs to the CinA family
UWK_RS01950	COG1058	Belongs to the CinA family
UWK_RS01955	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
UWK_RS01960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
UWK_RS01960	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
UWK_RS01975	COG1528	Iron-storage protein
UWK_RS02005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
UWK_RS02010	COG1074	ATP-dependent DNA helicase activity
UWK_RS02015	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
UWK_RS02175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
UWK_RS02180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UWK_RS02185	COG1648	precorrin-2 dehydrogenase activity
UWK_RS02185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UWK_RS02200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UWK_RS02205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UWK_RS02215	COG1381	Involved in DNA repair and RecF pathway recombination
UWK_RS02235	COG2226	methyltransferase
UWK_RS02240	COG0500	methyltransferase
UWK_RS02250	COG0537	adenosine 5'-monophosphoramidase activity
UWK_RS02255	COG0488	(ABC) transporter
UWK_RS02275	COG0189	ligase activity
UWK_RS02280	COG2920	part of a sulfur-relay system
UWK_RS02290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UWK_RS02295	COG1587	Uroporphyrinogen-III synthase
UWK_RS02295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UWK_RS02305	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
UWK_RS02310	COG0563	adenylate kinase activity
UWK_RS02320	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
UWK_RS02380	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
UWK_RS02440	COG1322	Protein conserved in bacteria
UWK_RS02445	COG3267	Type II secretory pathway component ExeA
UWK_RS02445	COG3409	Peptidoglycan-binding domain 1 protein
UWK_RS02455	COG0542	response to heat
UWK_RS02460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
UWK_RS02475	COG0697	spore germination
UWK_RS02485	COG2326	polyphosphate kinase activity
UWK_RS02490	COG1331	Highly conserved protein containing a thioredoxin domain
UWK_RS02510	COG0517	IMP dehydrogenase activity
UWK_RS02515	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
UWK_RS02540	COG0129	dihydroxy-acid dehydratase activity
UWK_RS02555	COG0516	GMP reductase activity
UWK_RS02555	COG0517	IMP dehydrogenase activity
UWK_RS02560	COG0539	negative regulation of cytoplasmic translation
UWK_RS02565	COG0776	regulation of translation
UWK_RS02570	COG0009	L-threonylcarbamoyladenylate synthase
UWK_RS02575	COG0517	IMP dehydrogenase activity
UWK_RS02575	COG0516	GMP reductase activity
UWK_RS02580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UWK_RS02580	COG0519	Catalyzes the synthesis of GMP from XMP
UWK_RS02585	COG0280	phosphate acetyltransferase
UWK_RS02585	COG0857	belongs to the CobB CobQ family
UWK_RS02610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UWK_RS02620	COG4149	molybdate abc transporter
UWK_RS02625	COG0725	ABC transporter, periplasmic molybdate-binding protein
UWK_RS02635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UWK_RS02660	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
UWK_RS02685	COG0784	Response regulator, receiver
UWK_RS02685	COG2205	protein histidine kinase activity
UWK_RS02740	COG0577	efflux transmembrane transporter activity
UWK_RS02745	COG0577	efflux transmembrane transporter activity
UWK_RS02745	COG1136	(ABC) transporter
UWK_RS02785	COG0438	transferase activity, transferring glycosyl groups
UWK_RS02790	COG0561	phosphatase activity
UWK_RS02790	COG3100	YcgL domain-containing protein
UWK_RS02800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UWK_RS02805	COG2239	Acts as a magnesium transporter
UWK_RS02900	COG0071	Belongs to the small heat shock protein (HSP20) family
UWK_RS02905	COG0189	ligase activity
UWK_RS02915	COG0010	Belongs to the arginase family
UWK_RS02930	COG1166	arginine decarboxylase activity
UWK_RS02945	COG0372	Belongs to the citrate synthase family
UWK_RS02965	COG1283	sodium-dependent phosphate transmembrane transporter activity
UWK_RS02970	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
UWK_RS02975	COG0598	Magnesium transport protein CorA
UWK_RS02990	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
UWK_RS03000	COG0668	transmembrane transport
UWK_RS03005	COG1283	sodium-dependent phosphate transmembrane transporter activity
UWK_RS03020	COG2204	response regulator
UWK_RS03050	COG0189	ligase activity
UWK_RS03070	COG0433	COG0433 Predicted ATPase
UWK_RS03075	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
UWK_RS03105	COG0837	glucose binding
UWK_RS03110	COG0840	transmembrane signaling receptor activity
UWK_RS03170	COG2204	response regulator
UWK_RS03185	COG0343	queuine tRNA-ribosyltransferase activity
UWK_RS03190	COG1862	Preprotein translocase
UWK_RS03205	COG0668	transmembrane transport
UWK_RS03215	COG0084	hydrolase, TatD family'
UWK_RS03220	COG1773	rubredoxin
UWK_RS03230	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
UWK_RS03235	COG0248	Ppx GppA phosphatase
UWK_RS03255	COG1215	transferase activity, transferring glycosyl groups
UWK_RS03265	COG3153	acetyltransferase
UWK_RS03265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UWK_RS03275	COG3550	peptidyl-serine autophosphorylation
UWK_RS03315	COG1484	DNA-dependent DNA replication
UWK_RS03320	COG4584	PFAM Integrase catalytic
UWK_RS03345	COG0582	viral genome integration into host DNA
UWK_RS03405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
UWK_RS03415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UWK_RS03425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
UWK_RS03425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UWK_RS03430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
UWK_RS03435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UWK_RS03440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
UWK_RS03455	COG0165	Argininosuccinate lyase
UWK_RS03460	COG0137	argininosuccinate synthase activity
UWK_RS03465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UWK_RS03470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UWK_RS03475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UWK_RS03510	COG3385	transposase activity
UWK_RS03525	COG2205	protein histidine kinase activity
UWK_RS03540	COG0745	RESPONSE REGULATOR receiver
UWK_RS03555	COG0038	chloride channel
UWK_RS03560	COG0469	pyruvate kinase activity
UWK_RS03590	COG5002	protein histidine kinase activity
UWK_RS03595	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
UWK_RS03595	COG0116	Belongs to the methyltransferase superfamily
UWK_RS03610	COG3083	sulfuric ester hydrolase activity
UWK_RS03615	COG0551	DNA topoisomerase type I activity
UWK_RS03615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UWK_RS03625	COG2814	Major facilitator Superfamily
UWK_RS03685	COG4771	TonB-dependent receptor
UWK_RS03700	COG0488	(ABC) transporter
UWK_RS03705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UWK_RS03760	COG0714	Associated with various cellular activities
UWK_RS03780	COG1132	(ABC) transporter
UWK_RS03785	COG1132	(ABC) transporter
UWK_RS03800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UWK_RS03805	COG0811	peptide transport
UWK_RS03810	COG0848	biopolymer transport protein
UWK_RS03860	COG1151	hydroxylamine reductase activity
UWK_RS03905	COG0745	RESPONSE REGULATOR receiver
UWK_RS03930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
UWK_RS03930	COG0517	IMP dehydrogenase activity
UWK_RS03930	COG0617	tRNA 3'-terminal CCA addition
UWK_RS03935	COG1309	transcriptional regulator
UWK_RS03940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UWK_RS03950	COG1136	(ABC) transporter
UWK_RS03975	COG0149	triose-phosphate isomerase activity
UWK_RS03980	COG0126	phosphoglycerate kinase activity
UWK_RS03995	COG1489	DNA binding
UWK_RS04000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
UWK_RS04005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
UWK_RS04010	COG0540	Belongs to the ATCase OTCase family
UWK_RS04015	COG0681	Belongs to the peptidase S26 family
UWK_RS04055	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
UWK_RS04065	COG1832	CoA-binding protein
UWK_RS04070	COG0752	glycyl-tRNA synthetase alpha subunit
UWK_RS04095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
UWK_RS04110	COG4221	oxidoreductase activity
UWK_RS04150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
UWK_RS04155	COG0242	peptide deformylase activity
UWK_RS04160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
UWK_RS04165	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
UWK_RS04170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UWK_RS04175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
UWK_RS04180	COG0351	phosphomethylpyrimidine kinase
UWK_RS04185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UWK_RS04190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UWK_RS04195	COG1116	anion transmembrane transporter activity
UWK_RS04200	COG1968	undecaprenyl-diphosphatase activity
UWK_RS04235	COG0651	ATP synthesis coupled electron transport
UWK_RS04250	COG0651	ATP synthesis coupled electron transport
UWK_RS04255	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UWK_RS04255	COG0649	NAD binding
UWK_RS04255	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UWK_RS04260	COG3260	NADH ubiquinone oxidoreductase 20
UWK_RS04265	COG0288	reversible hydration of carbon dioxide
UWK_RS04375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UWK_RS04390	COG0284	orotidine-5'-phosphate decarboxylase activity
UWK_RS04395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
UWK_RS04415	COG2409	Drug exporters of the RND superfamily
UWK_RS04445	COG1592	Rubrerythrin
UWK_RS04450	COG1592	Rubrerythrin
UWK_RS04450	COG1773	rubredoxin
UWK_RS04455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UWK_RS04460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
UWK_RS04465	COG0581	inorganic phosphate transmembrane transporter activity
UWK_RS04470	COG0573	inorganic phosphate transmembrane transporter activity
UWK_RS04480	COG0745	RESPONSE REGULATOR receiver
UWK_RS04485	COG5002	protein histidine kinase activity
UWK_RS04505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UWK_RS04505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UWK_RS04510	COG0504	CTP synthase activity
UWK_RS04515	COG2877	3-deoxy-8-phosphooctulonate synthase activity
UWK_RS04520	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
UWK_RS04560	COG1720	tRNA m6t6A37 methyltransferase activity
UWK_RS04565	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UWK_RS04565	COG2755	lipolytic protein G-D-S-L family
UWK_RS04595	COG3384	dioxygenase
UWK_RS04600	COG0562	UDP-galactopyranose mutase
UWK_RS04655	COG2226	methyltransferase
UWK_RS04660	COG1090	epimerase
UWK_RS04675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
UWK_RS04680	COG0864	Transcriptional regulator
UWK_RS04685	COG0310	cobalt ion transport
UWK_RS04690	COG0310	cobalt ion transport
UWK_RS04700	COG1122	ATPase activity
UWK_RS04720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
UWK_RS04725	COG1660	Displays ATPase and GTPase activities
UWK_RS04750	COG1305	Transglutaminase-like
UWK_RS04755	COG0534	Mate efflux family protein
UWK_RS04760	COG0778	Nitroreductase
UWK_RS04765	COG0835	chemotaxis
UWK_RS04795	COG0513	Belongs to the DEAD box helicase family
UWK_RS04810	COG3885	ferrous iron binding
UWK_RS04810	COG2078	PFAM AMMECR1 domain protein
UWK_RS04820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UWK_RS04825	COG0765	amino acid transport
UWK_RS04830	COG0778	Nitroreductase
UWK_RS04835	COG0477	Major facilitator Superfamily
UWK_RS04855	COG2205	protein histidine kinase activity
UWK_RS04865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UWK_RS04870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
UWK_RS04875	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
UWK_RS04880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
UWK_RS04890	COG0356	it plays a direct role in the translocation of protons across the membrane
UWK_RS04910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
UWK_RS04915	COG0745	RESPONSE REGULATOR receiver
UWK_RS04960	COG2823	Periplasmic or secreted lipoprotein
UWK_RS04985	COG3604	Transcriptional regulator
UWK_RS05040	COG0300	oxidoreductase activity
UWK_RS05045	COG0730	response to heat
UWK_RS05060	COG0418	dihydroorotase activity
UWK_RS05070	COG0704	Plays a role in the regulation of phosphate uptake
UWK_RS05075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UWK_RS05080	COG0581	inorganic phosphate transmembrane transporter activity
UWK_RS05085	COG0573	inorganic phosphate transmembrane transporter activity
UWK_RS05090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
UWK_RS05105	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
UWK_RS05120	COG0714	Associated with various cellular activities
UWK_RS05130	COG0527	aspartate kinase activity
UWK_RS05135	COG1917	Cupin 2, conserved barrel domain protein
UWK_RS05140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
UWK_RS05145	COG0456	acetyltransferase
UWK_RS05150	COG1509	lysine 2,3-aminomutase activity
UWK_RS05160	COG0701	Predicted permease
UWK_RS05175	COG1121	(ABC) transporter
UWK_RS05180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UWK_RS05230	COG0569	domain protein
UWK_RS05235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UWK_RS05245	COG0667	Aldo Keto reductase
UWK_RS05265	COG1073	alpha beta
UWK_RS05265	COG2226	methyltransferase
UWK_RS05285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UWK_RS05290	COG0765	amino acid transport
UWK_RS05310	COG0116	Belongs to the methyltransferase superfamily
UWK_RS05310	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
UWK_RS05315	COG2197	response regulator
UWK_RS05335	COG4191	Histidine kinase
UWK_RS05345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UWK_RS05360	COG0765	amino acid transport
UWK_RS05365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UWK_RS05375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
UWK_RS05375	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
UWK_RS05380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UWK_RS05385	COG0154	amidase activity
UWK_RS05390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UWK_RS05400	COG0123	including yeast histone deacetylase and acetoin utilization protein
UWK_RS05405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
UWK_RS05410	COG2391	methyltransferase activity
UWK_RS05415	COG0425	Belongs to the sulfur carrier protein TusA family
UWK_RS05430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UWK_RS05450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
UWK_RS05455	COG0628	permease
UWK_RS05460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
UWK_RS05465	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
UWK_RS05490	COG0011	TIGRFAM Protein of
UWK_RS05495	COG4584	PFAM Integrase catalytic
UWK_RS05500	COG1484	DNA-dependent DNA replication
UWK_RS05505	COG1475	DNA binding
UWK_RS05510	COG1192	Involved in chromosome partitioning
UWK_RS05515	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
UWK_RS05520	COG3830	Belongs to the UPF0237 family
UWK_RS05525	COG2848	UPF0210 protein
UWK_RS05550	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UWK_RS05560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UWK_RS05580	COG5002	protein histidine kinase activity
UWK_RS05615	COG0427	acetyl-CoA hydrolase
UWK_RS05640	COG2226	methyltransferase
UWK_RS05650	COG0328	RNA-DNA hybrid ribonuclease activity
UWK_RS05665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
UWK_RS05675	COG2264	protein methyltransferase activity
UWK_RS05695	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
UWK_RS05745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
UWK_RS05750	COG0124	histidyl-tRNA synthetase
UWK_RS05755	COG0617	tRNA 3'-terminal CCA addition
UWK_RS05765	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
UWK_RS05770	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
UWK_RS05780	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
UWK_RS05785	COG0298	carbon dioxide binding
UWK_RS05800	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
UWK_RS05805	COG0375	protein maturation
UWK_RS05820	COG0181	hydroxymethylbilane synthase activity
UWK_RS05860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UWK_RS05875	COG1012	belongs to the aldehyde dehydrogenase family
UWK_RS05875	COG1454	alcohol dehydrogenase
UWK_RS05885	COG1192	Involved in chromosome partitioning
UWK_RS05890	COG0686	Belongs to the AlaDH PNT family
UWK_RS05900	COG0148	phosphopyruvate hydratase activity
UWK_RS05930	COG0701	Predicted permease
UWK_RS05955	COG3118	belongs to the thioredoxin family
UWK_RS05980	COG2226	methyltransferase
UWK_RS06020	COG2204	response regulator
UWK_RS06025	COG4191	Histidine kinase
UWK_RS06040	COG0071	Belongs to the small heat shock protein (HSP20) family
UWK_RS06050	COG0514	ATP-dependent DNA helicase (RecQ)
UWK_RS06090	COG4942	peptidase
UWK_RS06100	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
UWK_RS06135	COG3385	transposase activity
UWK_RS06155	COG4584	PFAM Integrase catalytic
UWK_RS06160	COG1484	DNA-dependent DNA replication
UWK_RS06170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
UWK_RS06175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
UWK_RS06180	COG0047	phosphoribosylformylglycinamidine synthase activity
UWK_RS06180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UWK_RS06185	COG2354	Protein conserved in bacteria
UWK_RS06195	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
UWK_RS06205	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
UWK_RS06225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
UWK_RS06235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
UWK_RS06235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
UWK_RS06240	COG2195	Cleaves the N-terminal amino acid of tripeptides
UWK_RS06245	COG1309	transcriptional regulator
UWK_RS06270	COG0709	Synthesizes selenophosphate from selenide and ATP
UWK_RS06275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
UWK_RS06320	COG2194	sulfuric ester hydrolase activity
UWK_RS06330	COG2204	response regulator
UWK_RS06335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
UWK_RS06355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
UWK_RS06360	COG4191	Histidine kinase
UWK_RS06375	COG0437	4 iron, 4 sulfur cluster binding
UWK_RS06380	COG3383	formate dehydrogenase (NAD+) activity
UWK_RS06385	COG0243	molybdopterin cofactor binding
UWK_RS06410	COG2197	response regulator
UWK_RS06415	COG4585	Histidine kinase
UWK_RS06435	COG1151	hydroxylamine reductase activity
UWK_RS06445	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
UWK_RS06455	COG4822	anaerobic cobalamin biosynthetic process
UWK_RS06465	COG2204	response regulator
UWK_RS06470	COG1639	'signal transduction protein
UWK_RS06480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
UWK_RS06485	COG2964	Protein conserved in bacteria
UWK_RS06500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UWK_RS06505	COG0549	Belongs to the carbamate kinase family
UWK_RS06510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UWK_RS06530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
UWK_RS06530	COG0493	'glutamate synthase
UWK_RS06535	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
UWK_RS06535	COG3608	succinylglutamate desuccinylase aspartoacylase
UWK_RS06540	COG2233	PERMEase
UWK_RS06545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
UWK_RS06550	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
UWK_RS06555	COG2080	2 iron, 2 sulfur cluster binding
UWK_RS06560	COG0402	S-adenosylhomocysteine deaminase activity
UWK_RS06565	COG3845	ABC transporter
UWK_RS06570	COG4603	Belongs to the binding-protein-dependent transport system permease family
UWK_RS06575	COG1079	Belongs to the binding-protein-dependent transport system permease family
UWK_RS06600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UWK_RS06635	COG3527	Alpha-acetolactate decarboxylase
UWK_RS06685	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
UWK_RS06715	COG0367	asparagine synthase
UWK_RS06745	COG1215	transferase activity, transferring glycosyl groups
UWK_RS06755	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
UWK_RS06760	COG0457	Tetratricopeptide repeat
UWK_RS06775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UWK_RS06790	COG0076	glutamate decarboxylase activity
UWK_RS06795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UWK_RS06800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UWK_RS06825	COG0303	'Molybdopterin
UWK_RS06830	COG0303	'Molybdopterin
UWK_RS06840	COG0628	permease
UWK_RS06845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UWK_RS06850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
UWK_RS06855	COG0459	protein refolding
UWK_RS06900	COG0564	pseudouridine synthase activity
UWK_RS06905	COG2205	protein histidine kinase activity
UWK_RS06910	COG0745	RESPONSE REGULATOR receiver
UWK_RS06935	COG3706	GGDEF domain
UWK_RS06995	COG1131	(ABC) transporter
UWK_RS07000	COG0842	Transport permease protein
UWK_RS07025	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
UWK_RS07045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UWK_RS07065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UWK_RS07095	COG0330	HflC and HflK could
UWK_RS07170	COG4895	conserved protein (DUF2196)
UWK_RS07210	COG1309	transcriptional regulator
UWK_RS07230	COG0456	acetyltransferase
UWK_RS07235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UWK_RS07255	COG2226	methyltransferase
UWK_RS07260	COG1595	DNA-templated transcription, initiation
UWK_RS07280	COG0667	Aldo Keto reductase
UWK_RS07285	COG2271	Major facilitator Superfamily
UWK_RS07310	COG0826	peptidase U32
UWK_RS07340	COG0584	glycerophosphoryl diester phosphodiesterase
UWK_RS07345	COG1794	racemase activity, acting on amino acids and derivatives
UWK_RS07350	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
UWK_RS07355	COG0023	Translation Initiation Factor
UWK_RS07365	COG0513	Belongs to the DEAD box helicase family
UWK_RS07370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
UWK_RS07375	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UWK_RS07385	COG0701	Predicted permease
UWK_RS07390	COG0640	Transcriptional regulator
UWK_RS07395	COG1643	Atp-dependent helicase
UWK_RS07405	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UWK_RS07445	COG1592	Rubrerythrin
UWK_RS07450	COG0450	alkyl hydroperoxide reductase
UWK_RS07455	COG2033	superoxide reductase activity
UWK_RS07460	COG1773	rubredoxin
UWK_RS07470	COG0426	domain, Protein
UWK_RS07490	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
UWK_RS07495	COG0006	proline dipeptidase activity
UWK_RS07505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UWK_RS07505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
UWK_RS07520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UWK_RS07525	COG4597	amino acid ABC transporter
UWK_RS07530	COG0765	amino acid transport
UWK_RS07535	COG1126	abc transporter atp-binding protein
UWK_RS07575	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
UWK_RS07595	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
UWK_RS07605	COG3639	organic phosphonate transmembrane transporter activity
UWK_RS07625	COG3627	carbon phosphorus lyase activity
UWK_RS07630	COG4107	phosphonate C-P lyase system protein PhnK
UWK_RS07635	COG4778	phosphonate C-P lyase system protein PhnL
UWK_RS07640	COG3454	Phosphonate metabolism
UWK_RS07650	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
UWK_RS07685	COG0488	(ABC) transporter
UWK_RS07720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
UWK_RS07725	COG0573	inorganic phosphate transmembrane transporter activity
UWK_RS07730	COG0581	inorganic phosphate transmembrane transporter activity
UWK_RS07735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UWK_RS07745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
UWK_RS07750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UWK_RS07760	COG1131	(ABC) transporter
UWK_RS07775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UWK_RS07780	COG0655	NAD(P)H dehydrogenase (quinone) activity
UWK_RS07805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UWK_RS07810	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
UWK_RS07815	COG4770	biotin carboxylase activity
UWK_RS07825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UWK_RS07830	COG0346	lactoylglutathione lyase activity
UWK_RS07835	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UWK_RS07835	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UWK_RS07845	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UWK_RS07845	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UWK_RS07850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UWK_RS07855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UWK_RS07865	COG0045	succinate-CoA ligase (ADP-forming) activity
UWK_RS07875	COG1309	transcriptional regulator
UWK_RS07890	COG1227	inorganic diphosphatase activity
UWK_RS07900	COG1639	'signal transduction protein
UWK_RS07910	COG1959	2 iron, 2 sulfur cluster binding
UWK_RS07920	COG1271	oxidase subunit
UWK_RS07945	COG0628	permease
UWK_RS07950	COG0697	spore germination
UWK_RS07960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UWK_RS07960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UWK_RS07965	COG1011	Hydrolase
UWK_RS07975	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UWK_RS07985	COG1040	competence protein
UWK_RS07990	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UWK_RS08005	COG0326	Molecular chaperone. Has ATPase activity
UWK_RS08015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UWK_RS08025	COG0402	S-adenosylhomocysteine deaminase activity
UWK_RS08030	COG0012	GTP binding
UWK_RS08035	COG0470	DNA polymerase III
UWK_RS08040	COG1774	PSP1 C-terminal conserved region
UWK_RS08045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UWK_RS08045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UWK_RS08060	COG1872	DUF167
UWK_RS08065	COG0149	triose-phosphate isomerase activity
UWK_RS08070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
UWK_RS08075	COG1639	'signal transduction protein
UWK_RS08080	COG0501	Belongs to the peptidase M48B family
UWK_RS08090	COG0358	DNA primase activity
UWK_RS08100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
UWK_RS08100	COG0758	DNA mediated transformation
UWK_RS08105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UWK_RS08110	COG0166	Belongs to the GPI family
UWK_RS08115	COG2221	Nitrite and sulphite reductase 4Fe-4S
UWK_RS08120	COG2221	Nitrite and sulphite reductase 4Fe-4S
UWK_RS08135	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
UWK_RS08140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
UWK_RS08180	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UWK_RS08185	COG1691	(AIR) carboxylase
UWK_RS08195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UWK_RS08200	COG1671	Belongs to the UPF0178 family
UWK_RS08210	COG4628	conserved protein (DUF2132)
UWK_RS08215	COG3383	formate dehydrogenase (NAD+) activity
UWK_RS08220	COG0493	'glutamate synthase
UWK_RS08230	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
UWK_RS08245	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UWK_RS08250	COG0492	ferredoxin-NADP+ reductase activity
UWK_RS08255	COG3118	belongs to the thioredoxin family
UWK_RS08260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UWK_RS08275	COG0356	it plays a direct role in the translocation of protons across the membrane
UWK_RS08280	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UWK_RS08290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UWK_RS08295	COG0776	regulation of translation
UWK_RS08300	COG1187	pseudouridine synthase activity
UWK_RS08305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
UWK_RS08315	COG0432	Pfam Uncharacterised protein family UPF0047
UWK_RS08360	COG0456	acetyltransferase
UWK_RS08370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UWK_RS08375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
UWK_RS08380	COG0297	glycogen (starch) synthase activity
UWK_RS08390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UWK_RS08390	COG0574	Belongs to the PEP-utilizing enzyme family
UWK_RS08405	COG1686	Belongs to the peptidase S11 family
UWK_RS08435	COG2176	DNA-directed DNA polymerase activity
UWK_RS08445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UWK_RS08455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
UWK_RS08465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
UWK_RS08470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UWK_RS08475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
UWK_RS08480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
UWK_RS08485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
UWK_RS08490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
UWK_RS08505	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
UWK_RS08520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UWK_RS08530	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
UWK_RS08545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
UWK_RS08555	COG1032	radical SAM domain protein
UWK_RS08560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
UWK_RS08565	COG0708	Exodeoxyribonuclease III
UWK_RS08570	COG2197	response regulator
UWK_RS08620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UWK_RS08650	COG1538	Outer membrane efflux protein
UWK_RS08660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
UWK_RS08665	COG0445	tRNA wobble uridine modification
UWK_RS08685	COG0594	ribonuclease P activity
UWK_RS08690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
UWK_RS08695	COG0706	membrane insertase activity
UWK_RS08705	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
UWK_RS08715	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
UWK_RS08720	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
UWK_RS08745	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
UWK_RS08780	COG1091	dTDP-4-dehydrorhamnose reductase activity
UWK_RS08785	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
UWK_RS08795	COG0662	Cupin 2, conserved barrel domain protein
UWK_RS08795	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
UWK_RS08800	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
UWK_RS08805	COG0004	ammonium transporteR
UWK_RS08815	COG0347	Belongs to the P(II) protein family
UWK_RS08820	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
UWK_RS08860	COG4555	ABC transporter
UWK_RS08870	COG0529	Catalyzes the synthesis of activated sulfate
UWK_RS08875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UWK_RS08895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UWK_RS08920	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
UWK_RS08935	COG0673	inositol 2-dehydrogenase activity
UWK_RS08945	COG0297	glycogen (starch) synthase activity
UWK_RS08945	COG0438	transferase activity, transferring glycosyl groups
UWK_RS08955	COG0367	asparagine synthase
UWK_RS09010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UWK_RS09015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UWK_RS09020	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
UWK_RS09025	COG3206	protein involved in exopolysaccharide biosynthesis
UWK_RS09025	COG0489	protein tyrosine kinase activity
UWK_RS09050	COG0215	cysteine-tRNA ligase activity
UWK_RS09085	COG1217	gtp-binding protein TYPA
UWK_RS09100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
UWK_RS09125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
UWK_RS09135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UWK_RS09140	COG0587	DNA-directed DNA polymerase activity
UWK_RS09150	COG1022	Amp-dependent synthetase and ligase
UWK_RS09160	COG1994	Peptidase M50
UWK_RS09165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
UWK_RS09175	COG1121	(ABC) transporter
UWK_RS09180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UWK_RS09195	COG0617	tRNA 3'-terminal CCA addition
UWK_RS09195	COG3620	sequence-specific DNA binding
UWK_RS09195	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
UWK_RS09200	COG4974	Belongs to the 'phage' integrase family
UWK_RS09210	COG0277	FAD linked oxidase domain protein
UWK_RS09215	COG1181	Belongs to the D-alanine--D-alanine ligase family
UWK_RS09220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UWK_RS09230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
UWK_RS09235	COG0805	protein transport
UWK_RS09275	COG2274	protein secretion by the type I secretion system
UWK_RS09275	COG2274	protein secretion by the type I secretion system
UWK_RS09310	COG1136	(ABC) transporter
UWK_RS09315	COG0577	efflux transmembrane transporter activity
UWK_RS09330	COG0588	phosphoglycerate mutase activity
UWK_RS09335	COG0438	transferase activity, transferring glycosyl groups
UWK_RS09350	COG0110	maltose O-acetyltransferase activity
UWK_RS09370	COG2814	Major facilitator Superfamily
UWK_RS09375	COG3852	Histidine kinase
UWK_RS09385	COG1199	ATP-dependent helicase activity
UWK_RS09390	COG0142	geranyltranstransferase activity
UWK_RS09405	COG0138	bifunctional purine biosynthesis protein purh
UWK_RS09410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
UWK_RS09415	COG2022	thiamine diphosphate biosynthetic process
UWK_RS09425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
UWK_RS09430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
UWK_RS09470	COG0542	response to heat
UWK_RS09510	COG0557	exoribonuclease II activity
UWK_RS09515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UWK_RS09525	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
UWK_RS09540	COG0028	Belongs to the TPP enzyme family
UWK_RS09565	COG1792	Involved in formation and maintenance of cell shape
UWK_RS09580	COG0772	Belongs to the SEDS family
UWK_RS09595	COG0569	domain protein
UWK_RS09605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
UWK_RS09615	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
UWK_RS09630	COG0352	thiamine-phosphate diphosphorylase activity
UWK_RS09640	COG0330	HflC and HflK could
UWK_RS09660	COG2204	response regulator
UWK_RS09685	COG2204	response regulator
UWK_RS09700	COG2204	response regulator
UWK_RS09760	COG0463	Glycosyl transferase, family 2
UWK_RS09800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UWK_RS09855	COG1032	radical SAM domain protein
UWK_RS09865	COG0438	transferase activity, transferring glycosyl groups
UWK_RS09885	COG1136	(ABC) transporter
UWK_RS09890	COG0577	efflux transmembrane transporter activity
UWK_RS09895	COG0463	Glycosyl transferase, family 2
UWK_RS09935	COG0463	Glycosyl transferase, family 2
UWK_RS09955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UWK_RS09960	COG0438	transferase activity, transferring glycosyl groups
UWK_RS09975	COG1032	radical SAM domain protein
UWK_RS09980	COG0463	Glycosyl transferase, family 2
UWK_RS10000	COG1032	radical SAM domain protein
UWK_RS10005	COG0156	8-amino-7-oxononanoate synthase activity
UWK_RS10015	COG0196	riboflavin kinase activity
UWK_RS10040	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UWK_RS10040	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UWK_RS10045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
UWK_RS10050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UWK_RS10055	COG1674	ftsk spoiiie
UWK_RS10070	COG1233	COG1233 Phytoene dehydrogenase and related
UWK_RS10075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UWK_RS10105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UWK_RS10120	COG0250	Participates in transcription elongation, termination and antitermination
UWK_RS10125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
UWK_RS10130	COG0081	regulation of translation
UWK_RS10135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
UWK_RS10140	COG0222	ribosome binding
UWK_RS10145	COG0085	RNA polymerase activity
UWK_RS10150	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
UWK_RS10155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
UWK_RS10160	COG0049	tRNA binding
UWK_RS10165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UWK_RS10170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UWK_RS10175	COG0051	transcription antitermination factor activity, RNA binding
UWK_RS10180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UWK_RS10185	COG0088	Forms part of the polypeptide exit tunnel
UWK_RS10190	COG0089	rRNA binding
UWK_RS10195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
UWK_RS10200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
UWK_RS10205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
UWK_RS10210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
UWK_RS10215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
UWK_RS10220	COG0255	Belongs to the universal ribosomal protein uL29 family
UWK_RS10225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
UWK_RS10230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
UWK_RS10235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
UWK_RS10240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
UWK_RS10250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
UWK_RS10255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
UWK_RS10260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
UWK_RS10265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
UWK_RS10270	COG1841	ribosomal large subunit assembly
UWK_RS10275	COG0200	Binds to the 23S rRNA
UWK_RS10290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
UWK_RS10295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
UWK_RS10300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UWK_RS10305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
UWK_RS10310	COG0202	RNA polymerase activity
UWK_RS10315	COG0203	ribosomal protein L17
UWK_RS10325	COG0052	Belongs to the universal ribosomal protein uS2 family
UWK_RS10330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
UWK_RS10335	COG0528	UMP kinase activity
UWK_RS10340	COG0233	cytoplasmic translational termination
UWK_RS10355	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
UWK_RS10360	COG0750	zinc metalloprotease
UWK_RS10365	COG1214	PFAM Peptidase M22, glycoprotease
UWK_RS10370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
UWK_RS10375	COG0442	prolyl-tRNA aminoacylation
UWK_RS10420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UWK_RS10435	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
UWK_RS10440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
UWK_RS10465	COG2204	response regulator
UWK_RS10480	COG1773	rubredoxin
UWK_RS10480	COG1592	Rubrerythrin
UWK_RS10485	COG1295	ribonuclease BN
UWK_RS10505	COG0791	NLP P60 protein
UWK_RS10505	COG1388	LysM domain
UWK_RS10530	COG1418	mRNA catabolic process
UWK_RS10535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
UWK_RS10540	COG0735	belongs to the Fur family
UWK_RS10555	COG0058	SHG alpha-glucan phosphorylase activity
UWK_RS10560	COG2885	chlorophyll binding
UWK_RS10575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
UWK_RS10575	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
UWK_RS10580	COG1561	YicC-like family, N-terminal region
UWK_RS10585	COG2052	Domain of unknown function (DUF370)
UWK_RS10590	COG0194	GDP metabolic process
UWK_RS10595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UWK_RS10610	COG5002	protein histidine kinase activity
UWK_RS10615	COG2204	response regulator
UWK_RS10620	COG5002	protein histidine kinase activity
UWK_RS10630	COG5002	protein histidine kinase activity
UWK_RS10630	COG2198	Histidine kinase
UWK_RS10630	COG0784	Response regulator, receiver
UWK_RS10645	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
UWK_RS10650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
UWK_RS10660	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
UWK_RS10670	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
UWK_RS10680	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UWK_RS10685	COG1881	PFAM PEBP family protein
UWK_RS10700	COG4584	PFAM Integrase catalytic
UWK_RS10705	COG1484	DNA-dependent DNA replication
UWK_RS10710	COG1917	Cupin 2, conserved barrel domain protein
UWK_RS10735	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
UWK_RS10755	COG4175	Glycine betaine
UWK_RS10760	COG4176	ABC-type proline glycine betaine transport system permease component
UWK_RS10765	COG2113	Glycine betaine
UWK_RS10795	COG1136	(ABC) transporter
UWK_RS10800	COG0577	efflux transmembrane transporter activity
UWK_RS10800	COG1136	(ABC) transporter
UWK_RS10810	COG2183	response to ionizing radiation
UWK_RS10820	COG2204	response regulator
UWK_RS10825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UWK_RS10830	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
UWK_RS10860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
UWK_RS10875	COG3273	potassium ion transport
UWK_RS10875	COG0471	metal ion transport
UWK_RS10890	COG1607	acyl-coa hydrolase
UWK_RS10915	COG1773	rubredoxin
UWK_RS10920	COG2911	Protein conserved in bacteria
UWK_RS10925	COG0729	surface antigen
UWK_RS10935	COG1280	lysine exporter protein (LysE YggA)
UWK_RS10940	COG0436	Aminotransferase
UWK_RS10945	COG0484	heat shock protein binding
UWK_RS10950	COG0552	protein localization to endoplasmic reticulum
UWK_RS10955	COG0489	protein tyrosine kinase activity
UWK_RS10960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UWK_RS10975	COG0437	4 iron, 4 sulfur cluster binding
UWK_RS10980	COG3005	denitrification pathway
UWK_RS10990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UWK_RS11020	COG0037	tRNA processing
UWK_RS11025	COG0745	RESPONSE REGULATOR receiver
UWK_RS11040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
UWK_RS11050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UWK_RS11090	COG3344	reverse transcriptase
UWK_RS11130	COG1355	regulation of microtubule-based process
UWK_RS11135	COG0215	cysteine-tRNA ligase activity
UWK_RS11170	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
UWK_RS11180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UWK_RS11210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
UWK_RS11265	COG4680	protein conserved in bacteria
UWK_RS11270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
UWK_RS11270	COG0546	phosphoglycolate phosphatase activity
UWK_RS11280	COG1131	(ABC) transporter
UWK_RS11340	COG2217	Heavy metal translocating P-type atpase
UWK_RS11345	COG2046	Belongs to the sulfate adenylyltransferase family
UWK_RS11350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
UWK_RS11360	COG2204	response regulator
UWK_RS11365	COG4191	Histidine kinase
UWK_RS11405	COG0243	molybdopterin cofactor binding
UWK_RS11415	COG0437	4 iron, 4 sulfur cluster binding
UWK_RS11440	COG0590	tRNA wobble adenosine to inosine editing
UWK_RS11440	COG0037	tRNA processing
UWK_RS11455	COG0805	protein transport
UWK_RS11465	COG0348	domain, Protein
UWK_RS11470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
UWK_RS11475	COG1758	RNA polymerase activity
UWK_RS11480	COG0484	heat shock protein binding
UWK_RS11490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UWK_RS11500	COG2204	response regulator
UWK_RS11505	COG1469	GTP cyclohydrolase I activity
UWK_RS11510	COG0751	glycine-tRNA ligase activity
UWK_RS11525	COG1333	cytochrome c biogenesis protein
UWK_RS11530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UWK_RS11540	COG1028	Short-chain dehydrogenase reductase Sdr
UWK_RS11545	COG2226	methyltransferase
UWK_RS11550	COG0612	Peptidase, M16
UWK_RS11565	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
UWK_RS11570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UWK_RS11575	COG1120	ATPase activity
UWK_RS11580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UWK_RS11585	COG1704	LemA family
UWK_RS11610	COG0616	signal peptide processing
UWK_RS11615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UWK_RS11620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UWK_RS11625	COG3034	peptidoglycan biosynthetic process
UWK_RS11645	COG3118	belongs to the thioredoxin family
UWK_RS11650	COG0613	PHP domain protein
UWK_RS11655	COG2204	response regulator
UWK_RS11660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UWK_RS11665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UWK_RS11675	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
UWK_RS11675	COG3264	Mechanosensitive ion channel
UWK_RS11680	COG2223	nitrite transmembrane transporter activity
UWK_RS11690	COG1696	Membrane protein involved in D-alanine export
UWK_RS11695	COG0574	Belongs to the PEP-utilizing enzyme family
UWK_RS11695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UWK_RS11700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UWK_RS11710	COG1104	cysteine desulfurase activity
UWK_RS11720	COG2759	Belongs to the formate--tetrahydrofolate ligase family
UWK_RS11725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
UWK_RS11770	COG0500	methyltransferase
UWK_RS11775	COG1132	(ABC) transporter
UWK_RS11780	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
UWK_RS11785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
UWK_RS11785	COG1519	Transferase
UWK_RS11790	COG2204	response regulator
UWK_RS11795	COG4191	Histidine kinase
UWK_RS11820	COG4206	TonB-dependent receptor
UWK_RS11870	COG0598	Magnesium transport protein CorA
UWK_RS11875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UWK_RS11880	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
UWK_RS11885	COG2239	Acts as a magnesium transporter
UWK_RS11900	COG0232	Belongs to the dGTPase family. Type 2 subfamily
UWK_RS11910	COG0497	DNA recombination
UWK_RS11925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UWK_RS11935	COG1682	transport, permease protein
UWK_RS11945	COG1215	transferase activity, transferring glycosyl groups
UWK_RS11965	COG3594	Acyltransferase
UWK_RS11980	COG1086	Polysaccharide biosynthesis protein
UWK_RS11985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UWK_RS11990	COG1083	cytidylyl-transferase
UWK_RS12010	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
UWK_RS12015	COG2089	acid synthase
UWK_RS12030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
UWK_RS12050	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
UWK_RS12055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UWK_RS12080	COG1696	Membrane protein involved in D-alanine export
UWK_RS12085	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
UWK_RS12095	COG0673	inositol 2-dehydrogenase activity
UWK_RS12115	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
UWK_RS12120	COG0483	inositol monophosphate 1-phosphatase activity
UWK_RS12125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UWK_RS12135	COG1132	(ABC) transporter
UWK_RS12140	COG0673	inositol 2-dehydrogenase activity
UWK_RS12145	COG1083	cytidylyl-transferase
UWK_RS12175	COG3385	transposase activity
UWK_RS12185	COG0438	transferase activity, transferring glycosyl groups
UWK_RS12205	COG1215	transferase activity, transferring glycosyl groups
UWK_RS12240	COG2192	nodulation
UWK_RS12280	COG0577	efflux transmembrane transporter activity
UWK_RS12280	COG1136	(ABC) transporter
UWK_RS12285	COG1136	(ABC) transporter
UWK_RS12285	COG0577	efflux transmembrane transporter activity
UWK_RS12295	COG0463	Glycosyl transferase, family 2
UWK_RS12325	COG0670	Belongs to the BI1 family
UWK_RS12330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
UWK_RS12340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UWK_RS12345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UWK_RS12350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UWK_RS12365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UWK_RS12370	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
UWK_RS12375	COG0193	aminoacyl-tRNA hydrolase activity
UWK_RS12385	COG0564	pseudouridine synthase activity
UWK_RS12390	COG0237	dephospho-CoA kinase activity
UWK_RS12395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
UWK_RS12400	COG0254	rRNA binding
UWK_RS12405	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
UWK_RS12410	COG2890	protein-(glutamine-N5) methyltransferase activity
UWK_RS12415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UWK_RS12425	COG2204	response regulator
UWK_RS12430	COG2827	Endonuclease containing a URI domain
UWK_RS12440	COG0805	protein transport
UWK_RS12455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
UWK_RS12465	COG1722	exodeoxyribonuclease VII activity
UWK_RS12470	COG4974	Belongs to the 'phage' integrase family
UWK_RS12475	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
UWK_RS12480	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
UWK_RS12495	COG0587	DNA-directed DNA polymerase activity
UWK_RS12540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
UWK_RS12550	COG3706	GGDEF domain
UWK_RS12560	COG1127	ABC transporter
UWK_RS12565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
UWK_RS12590	COG0784	Response regulator, receiver
UWK_RS12590	COG3437	response regulator, receiver
UWK_RS12600	COG0501	Belongs to the peptidase M48B family
UWK_RS12610	COG0668	transmembrane transport
UWK_RS12645	COG0826	peptidase U32
UWK_RS12650	COG3613	nucleoside 2-deoxyribosyltransferase
UWK_RS12655	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
UWK_RS12660	COG4174	ABC transporter (Permease)
UWK_RS12665	COG4239	(ABC) transporter, permease
UWK_RS12670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
UWK_RS12675	COG1127	ABC transporter
UWK_RS12680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
UWK_RS12705	COG0416	fatty acid biosynthetic process
UWK_RS12710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UWK_RS12720	COG2086	electron transfer activity
UWK_RS12725	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
UWK_RS12730	COG1028	Short-chain dehydrogenase reductase Sdr
UWK_RS12740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UWK_RS12745	COG0698	ribose 5-phosphate isomerase
UWK_RS12750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UWK_RS12755	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
UWK_RS12760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UWK_RS12760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UWK_RS12775	COG1459	type II secretion system
UWK_RS12785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UWK_RS12790	COG0084	hydrolase, TatD family'
UWK_RS12795	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
UWK_RS12805	COG1100	Small GTP-binding protein
UWK_RS12825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
UWK_RS12830	COG0742	ribosomal rna small subunit methyltransferase
UWK_RS12835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
UWK_RS12840	COG1183	phosphatidylcholine synthase activity
UWK_RS12845	COG0688	phosphatidylethanolamine metabolic process
UWK_RS12850	COG0440	acetolactate synthase activity
UWK_RS12855	COG0028	Belongs to the TPP enzyme family
UWK_RS12860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UWK_RS12880	COG0517	IMP dehydrogenase activity
UWK_RS12890	COG0427	acetyl-CoA hydrolase
UWK_RS12905	COG3008	intermembrane lipid transfer
UWK_RS12910	COG2995	paraquat-inducible protein a
UWK_RS12930	COG4651	solute:proton antiporter activity
UWK_RS12930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
UWK_RS12950	COG0823	Involved in the tonB-independent uptake of proteins
UWK_RS12950	COG4946	Tricorn protease homolog
UWK_RS12950	COG1506	peptidase
UWK_RS12955	COG2204	response regulator
UWK_RS12965	COG3273	potassium ion transport
UWK_RS12965	COG0471	metal ion transport
UWK_RS12970	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UWK_RS12980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UWK_RS13010	COG1979	alcohol dehydrogenase
UWK_RS13015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UWK_RS13030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
UWK_RS13035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UWK_RS13040	COG0077	Prephenate dehydratase
UWK_RS13040	COG1605	Chorismate mutase
UWK_RS13050	COG1606	tRNA processing
UWK_RS13060	COG2197	response regulator
UWK_RS13065	COG0556	nucleotide-excision repair
UWK_RS13075	COG1797	cobyrinic acid a,c-diamide synthase activity
UWK_RS13085	COG0437	4 iron, 4 sulfur cluster binding
UWK_RS13120	COG2204	response regulator
UWK_RS13155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UWK_RS13160	COG0018	arginyl-trna synthetase
UWK_RS13170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
UWK_RS13175	COG0653	protein targeting
UWK_RS13200	COG2326	polyphosphate kinase activity
UWK_RS13205	COG2326	polyphosphate kinase activity
UWK_RS13215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UWK_RS13220	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
UWK_RS13225	COG1192	Involved in chromosome partitioning
UWK_RS13240	COG3977	Valine--pyruvate aminotransferase
UWK_RS13255	COG1473	amidohydrolase
UWK_RS13260	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
UWK_RS13265	COG0405	Gamma-glutamyltransferase
UWK_RS13270	COG1918	ferrous iron import across plasma membrane
UWK_RS13270	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
UWK_RS13290	COG5001	Diguanylate cyclase
UWK_RS13320	COG0631	protein serine/threonine phosphatase activity
UWK_RS13450	COG0577	efflux transmembrane transporter activity
UWK_RS13450	COG1136	(ABC) transporter
UWK_RS13455	COG0577	efflux transmembrane transporter activity
UWK_RS13455	COG1136	(ABC) transporter
UWK_RS13515	COG3344	reverse transcriptase
UWK_RS13550	COG1640	4-alpha-glucanotransferase
UWK_RS13560	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
UWK_RS13565	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
UWK_RS13570	COG0402	S-adenosylhomocysteine deaminase activity
UWK_RS13575	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
UWK_RS13580	COG0163	prenyltransferase activity
UWK_RS13585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
UWK_RS13595	COG0563	adenylate kinase activity
UWK_RS13600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
UWK_RS13605	COG2198	Histidine kinase
UWK_RS13605	COG0784	Response regulator, receiver
UWK_RS13605	COG2205	protein histidine kinase activity
UWK_RS13610	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UWK_RS13620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UWK_RS13625	COG1120	ATPase activity
UWK_RS13695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UWK_RS13700	COG1213	nucleotidyl transferase
UWK_RS13715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
UWK_RS13720	COG1702	phosphate starvation-inducible protein PhoH
UWK_RS13725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
UWK_RS13725	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
UWK_RS13735	COG0544	peptidyl-prolyl cis-trans isomerase activity
UWK_RS13740	COG0740	serine-type endopeptidase activity
UWK_RS13745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
UWK_RS13750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UWK_RS13770	COG0583	DNA-binding transcription factor activity
UWK_RS13780	COG1410	methionine synthase
UWK_RS13780	COG0646	methionine synthase
UWK_RS13785	COG1410	methionine synthase
UWK_RS13785	COG0646	methionine synthase
UWK_RS13800	COG0322	excinuclease ABC activity
UWK_RS13805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
UWK_RS13810	COG0488	(ABC) transporter
UWK_RS13820	COG2204	response regulator
UWK_RS13835	COG0243	molybdopterin cofactor binding
UWK_RS13860	COG2204	response regulator
UWK_RS13865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UWK_RS13870	COG3959	Transketolase, thiamine diphosphate binding domain
UWK_RS13885	COG0495	leucyl-tRNA aminoacylation
UWK_RS13890	COG0305	Participates in initiation and elongation during chromosome replication
UWK_RS13895	COG0359	binds to the 23S rRNA
UWK_RS13905	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UWK_RS13910	COG0360	Binds together with S18 to 16S ribosomal RNA
UWK_RS13915	COG3956	TIGRFAM MazG family protein
UWK_RS13925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
UWK_RS13930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
UWK_RS13935	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
UWK_RS13940	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UWK_RS13945	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UWK_RS13950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
UWK_RS13965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
UWK_RS13965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
UWK_RS13995	COG1530	ribonuclease E activity
UWK_RS14000	COG1216	Glycosyl transferase, family 2
UWK_RS14000	COG1442	glycosyl transferase family 8
UWK_RS14015	COG0484	heat shock protein binding
UWK_RS14020	COG0066	3-isopropylmalate dehydratase activity
UWK_RS14025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
UWK_RS14030	COG4166	transmembrane transport
UWK_RS14040	COG0802	atpase or kinase
UWK_RS14045	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
UWK_RS14050	COG1944	ATP diphosphatase activity
UWK_RS14060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
UWK_RS14065	COG1619	proteins homologs of microcin C7 resistance protein MccF
UWK_RS14070	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
UWK_RS14090	COG4120	Belongs to the binding-protein-dependent transport system permease family
UWK_RS14125	COG0351	phosphomethylpyrimidine kinase
UWK_RS14195	COG2204	response regulator
UWK_RS14200	COG4191	Histidine kinase
UWK_RS14225	COG5002	protein histidine kinase activity
UWK_RS14230	COG1846	Transcriptional regulator
UWK_RS14235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UWK_RS14240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UWK_RS14270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UWK_RS14280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
UWK_RS14295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
UWK_RS14305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UWK_RS14310	COG0527	aspartate kinase activity
UWK_RS14330	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
UWK_RS14340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UWK_RS14360	COG1013	pyruvate-flavodoxin oxidoreductase activity
UWK_RS14365	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
UWK_RS14365	COG0674	pyruvate-flavodoxin oxidoreductase activity
UWK_RS14375	COG0439	Biotin carboxylase
UWK_RS14395	COG1320	monovalent cation:proton antiporter activity
UWK_RS14415	COG0651	ATP synthesis coupled electron transport
UWK_RS14420	COG0651	ATP synthesis coupled electron transport
UWK_RS14455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
UWK_RS14465	COG0134	indole-3-glycerol-phosphate synthase activity
UWK_RS14470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UWK_RS14475	COG0512	Glutamine amidotransferase of anthranilate synthase
UWK_RS14485	COG0268	Binds directly to 16S ribosomal RNA
UWK_RS14505	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
UWK_RS14510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
UWK_RS14515	COG0138	bifunctional purine biosynthesis protein purh
UWK_RS14525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
UWK_RS14530	COG1469	GTP cyclohydrolase I activity
UWK_RS14535	COG3028	Belongs to the UPF0307 family
UWK_RS14540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
UWK_RS14550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UWK_RS14555	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
UWK_RS14560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
UWK_RS14580	COG5645	(Lipo)protein
UWK_RS14620	COG1484	DNA-dependent DNA replication
UWK_RS14625	COG4584	PFAM Integrase catalytic
UWK_RS14645	COG1797	cobyrinic acid a,c-diamide synthase activity
UWK_RS14650	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
UWK_RS14660	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
UWK_RS14665	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
UWK_RS14690	COG0745	RESPONSE REGULATOR receiver
UWK_RS14710	COG1205	dead DEAH box helicase
UWK_RS14710	COG1111	helicase
UWK_RS14715	COG1605	Chorismate mutase
UWK_RS14715	COG0287	Prephenate dehydrogenase
UWK_RS14750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UWK_RS14775	COG0811	peptide transport
UWK_RS14790	COG0823	Involved in the tonB-independent uptake of proteins
UWK_RS14805	COG0656	L-ascorbic acid biosynthetic process
UWK_RS14810	COG2204	response regulator
UWK_RS14840	COG0243	molybdopterin cofactor binding
UWK_RS14845	COG4783	chaperone-mediated protein folding
UWK_RS14850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UWK_RS14855	COG0318	PFAM AMP-dependent synthetase and ligase
UWK_RS14860	COG0596	Alpha beta hydrolase
UWK_RS14865	COG4172	Belongs to the ABC transporter superfamily
UWK_RS14875	COG0009	L-threonylcarbamoyladenylate synthase
UWK_RS14880	COG0151	Belongs to the GarS family
UWK_RS14885	COG1309	transcriptional regulator
UWK_RS14890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UWK_RS14905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UWK_RS14910	COG0481	GTPase activity
UWK_RS14920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
UWK_RS14925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
UWK_RS14930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UWK_RS14935	COG1047	Peptidyl-prolyl cis-trans
UWK_RS14940	COG0784	Response regulator, receiver
UWK_RS14940	COG0643	Histidine kinase
UWK_RS14940	COG2198	Histidine kinase
UWK_RS14945	COG0835	chemotaxis
UWK_RS14950	COG2201	protein-glutamate methylesterase activity
UWK_RS14955	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UWK_RS14960	COG2204	response regulator
UWK_RS14975	COG0437	4 iron, 4 sulfur cluster binding
UWK_RS14990	COG4191	Histidine kinase
UWK_RS15040	COG0437	4 iron, 4 sulfur cluster binding
UWK_RS15065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UWK_RS15070	COG0484	heat shock protein binding
UWK_RS15075	COG0437	4 iron, 4 sulfur cluster binding
UWK_RS15075	COG3064	Membrane
UWK_RS15080	COG5557	Pfam Polysulphide reductase, NrfD
UWK_RS15090	COG0583	DNA-binding transcription factor activity
UWK_RS15125	COG4191	Histidine kinase
UWK_RS15140	COG5609	conserved protein (DUF2294)
UWK_RS15145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UWK_RS15150	COG0505	Belongs to the CarA family
UWK_RS15170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
UWK_RS15175	COG1013	pyruvate-flavodoxin oxidoreductase activity
UWK_RS15175	COG0674	pyruvate-flavodoxin oxidoreductase activity
UWK_RS15175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
UWK_RS15175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
UWK_RS15190	COG0439	Biotin carboxylase
UWK_RS15200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UWK_RS15225	COG0745	RESPONSE REGULATOR receiver
UWK_RS15235	COG1815	bacterial-type flagellum-dependent cell motility
UWK_RS15240	COG1558	bacterial-type flagellum-dependent cell motility
UWK_RS15245	COG1677	Flagellar hook-basal body complex protein FliE
UWK_RS15255	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UWK_RS15265	COG1157	protein secretion by the type III secretion system
UWK_RS15285	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
UWK_RS15295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
UWK_RS15325	COG1338	Plays a role in the flagellum-specific transport system
UWK_RS15330	COG1987	bacterial-type flagellum assembly
UWK_RS15335	COG1684	flagellar biosynthetic protein fliR
UWK_RS15340	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UWK_RS15345	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UWK_RS15360	COG1191	sigma factor activity
UWK_RS15370	COG4786	Flagellar basal body rod
UWK_RS15375	COG4786	Flagellar basal body rod
UWK_RS15385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
UWK_RS15390	COG1706	bacterial-type flagellum-dependent cell motility
UWK_RS15415	COG4786	Flagellar basal body rod
UWK_RS15420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UWK_RS15425	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
UWK_RS15430	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
UWK_RS15445	COG1516	flagellar protein fliS
UWK_RS15450	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
UWK_RS15485	COG2089	acid synthase
UWK_RS15510	COG2257	FlhB HrpN YscU SpaS Family
UWK_RS15515	COG2321	neutral zinc metallopeptidase
UWK_RS15520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
UWK_RS15525	COG1253	flavin adenine dinucleotide binding
UWK_RS15535	COG2239	Acts as a magnesium transporter
UWK_RS15550	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
UWK_RS15555	COG0521	Mo-molybdopterin cofactor biosynthetic process
UWK_RS15560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UWK_RS15565	COG0728	peptidoglycan biosynthetic process
UWK_RS15570	COG0513	Belongs to the DEAD box helicase family
UWK_RS15580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UWK_RS15615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
UWK_RS15620	COG0737	Belongs to the 5'-nucleotidase family
UWK_RS15625	COG1227	inorganic diphosphatase activity
UWK_RS15640	COG1362	aminopeptidase activity
UWK_RS15665	COG1233	COG1233 Phytoene dehydrogenase and related
UWK_RS15670	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
UWK_RS15675	COG3383	formate dehydrogenase (NAD+) activity
UWK_RS15680	COG0493	'glutamate synthase
UWK_RS15680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
UWK_RS15700	COG1151	hydroxylamine reductase activity
UWK_RS15705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
UWK_RS15710	COG0281	malic enzyme
UWK_RS15715	COG1509	lysine 2,3-aminomutase activity
UWK_RS15730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
UWK_RS15735	COG1643	Atp-dependent helicase
UWK_RS15740	COG0391	Required for morphogenesis under gluconeogenic growth conditions
UWK_RS15745	COG0039	L-malate dehydrogenase activity
UWK_RS15750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
UWK_RS15755	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
UWK_RS15765	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
UWK_RS15775	COG1678	Uncharacterized ACR, COG1678
UWK_RS15780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
UWK_RS15795	COG4191	Histidine kinase
UWK_RS15815	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UWK_RS15830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
UWK_RS15840	COG3012	SEC-C Motif Domain Protein
UWK_RS15850	COG1494	fructose-1,6-bisphosphatase
UWK_RS15855	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
UWK_RS15875	COG5002	protein histidine kinase activity
UWK_RS15890	COG5002	protein histidine kinase activity
UWK_RS15910	COG0038	chloride channel
UWK_RS15925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UWK_RS15935	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
UWK_RS15945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
UWK_RS15960	COG3437	response regulator, receiver
UWK_RS16030	COG0606	chelatase, subunit chli
UWK_RS16035	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
UWK_RS16045	COG0720	synthase
UWK_RS16050	COG0602	queuosine metabolic process
UWK_RS16055	COG0303	'Molybdopterin
UWK_RS16060	COG0564	pseudouridine synthase activity
UWK_RS16065	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UWK_RS16070	COG0673	inositol 2-dehydrogenase activity
UWK_RS16080	COG0411	ABC transporter
UWK_RS16100	COG1663	tetraacyldisaccharide 4'-kinase activity
UWK_RS16105	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
UWK_RS16115	COG0432	Pfam Uncharacterised protein family UPF0047
UWK_RS16120	COG0107	imidazoleglycerol-phosphate synthase activity
UWK_RS16145	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
UWK_RS16155	COG0328	RNA-DNA hybrid ribonuclease activity
UWK_RS16165	COG1151	hydroxylamine reductase activity
UWK_RS16170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UWK_RS16185	COG0179	Fumarylacetoacetate (FAA) hydrolase
UWK_RS16190	COG4399	Belongs to the UPF0754 family
UWK_RS16195	COG0546	phosphoglycolate phosphatase activity
UWK_RS16205	COG1053	succinate dehydrogenase
UWK_RS16220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UWK_RS16230	COG0308	aminopeptidase N
UWK_RS16235	COG0436	Aminotransferase
UWK_RS16240	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
UWK_RS16245	COG1454	alcohol dehydrogenase
UWK_RS16285	COG0516	GMP reductase activity
UWK_RS16285	COG0517	IMP dehydrogenase activity
UWK_RS16295	COG0437	4 iron, 4 sulfur cluster binding
UWK_RS16310	COG0243	molybdopterin cofactor binding
UWK_RS16340	COG0058	SHG alpha-glucan phosphorylase activity
UWK_RS16345	COG1067	ATP-dependent peptidase activity
UWK_RS16365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
UWK_RS16375	COG1136	(ABC) transporter
UWK_RS16395	COG3852	Histidine kinase
UWK_RS16400	COG1519	Transferase
UWK_RS16405	COG2333	competence protein COMEC
UWK_RS16405	COG0658	competence protein
UWK_RS16425	COG1611	Belongs to the LOG family
UWK_RS16435	COG1921	L-seryl-tRNASec selenium transferase activity
UWK_RS16470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
UWK_RS16475	COG1484	DNA-dependent DNA replication
UWK_RS16480	COG4584	PFAM Integrase catalytic
UWK_RS16485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
UWK_RS16490	COG2233	PERMEase
UWK_RS16495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
UWK_RS16505	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
UWK_RS16510	COG0133	tryptophan synthase activity
UWK_RS16515	COG0159	tryptophan synthase activity
UWK_RS16520	COG2204	response regulator
UWK_RS16540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
UWK_RS16545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
UWK_RS16550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
UWK_RS16560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UWK_RS16565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
UWK_RS16570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
UWK_RS16575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
UWK_RS16580	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
UWK_RS16585	COG0072	phenylalanine-tRNA ligase activity
UWK_RS16585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UWK_RS16620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
UWK_RS16625	COG0228	four-way junction DNA binding
UWK_RS16630	COG1837	Belongs to the UPF0109 family
UWK_RS16635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
UWK_RS16640	COG0336	Belongs to the RNA methyltransferase TrmD family
UWK_RS16645	COG4752	Belongs to the RNA methyltransferase TrmD family
UWK_RS16650	COG0335	large ribosomal subunit rRNA binding
UWK_RS16655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UWK_RS16660	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
UWK_RS16665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UWK_RS16690	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
UWK_RS16705	COG0301	tRNA thio-modification
UWK_RS16705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UWK_RS16715	COG0420	3'-5' exonuclease activity
UWK_RS16720	COG0419	ATPase involved in DNA repair
UWK_RS16735	COG1192	Involved in chromosome partitioning
UWK_RS16795	COG0110	maltose O-acetyltransferase activity
UWK_RS16840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
UWK_RS16845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
UWK_RS16850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UWK_RS16855	COG1596	polysaccharide export
UWK_RS16870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
UWK_RS16875	COG4106	trans-aconitate 2-methyltransferase activity
UWK_RS16885	COG0156	8-amino-7-oxononanoate synthase activity
UWK_RS16890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UWK_RS16895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
UWK_RS16900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
UWK_RS16905	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
UWK_RS16910	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
UWK_RS16915	COG2894	cell division
UWK_RS16920	COG2884	Cell division ATP-binding protein ftsE
UWK_RS16925	COG2177	Part of the ABC transporter FtsEX involved in
UWK_RS16935	COG0793	Belongs to the peptidase S41A family
UWK_RS16945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
UWK_RS16970	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
UWK_RS16975	COG1342	Belongs to the UPF0251 family
UWK_RS17000	COG5000	phosphorelay sensor kinase activity
UWK_RS17005	COG2204	response regulator
UWK_RS17010	COG0113	porphobilinogen synthase activity
UWK_RS17025	COG0653	protein targeting
UWK_RS17040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UWK_RS17045	COG4106	trans-aconitate 2-methyltransferase activity
UWK_RS17050	COG0714	Associated with various cellular activities
UWK_RS17055	COG4548	von Willebrand factor, type A
UWK_RS17065	COG2989	Protein conserved in bacteria
UWK_RS17070	COG3108	Peptidase M15
UWK_RS17095	COG1136	(ABC) transporter
UWK_RS17115	COG0285	dihydrofolate synthase activity
UWK_RS17125	COG0210	DNA helicase
UWK_RS17140	COG1472	Belongs to the glycosyl hydrolase 3 family
UWK_RS17155	COG3437	response regulator, receiver
UWK_RS17185	COG1744	ABC transporter substrate-binding protein PnrA-like
UWK_RS17190	COG1129	ABC transporter
UWK_RS17195	COG4603	Belongs to the binding-protein-dependent transport system permease family
UWK_RS17200	COG1079	Belongs to the binding-protein-dependent transport system permease family
UWK_RS17205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
UWK_RS17205	COG0512	Glutamine amidotransferase of anthranilate synthase
UWK_RS17210	COG0517	IMP dehydrogenase activity
UWK_RS17215	COG0674	pyruvate-flavodoxin oxidoreductase activity
UWK_RS17215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
UWK_RS17215	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
UWK_RS17215	COG1013	pyruvate-flavodoxin oxidoreductase activity
UWK_RS17230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
UWK_RS17240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UWK_RS17245	COG0390	transport system, permease component
UWK_RS17250	COG4619	ABC transporter
UWK_RS17255	COG4191	Histidine kinase
UWK_RS17265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
UWK_RS17280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
UWK_RS17285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UWK_RS17290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
UWK_RS17295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UWK_RS17300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UWK_RS17305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UWK_RS17310	COG0768	penicillin binding
UWK_RS17320	COG0275	rRNA processing
UWK_RS17325	COG2001	Belongs to the MraZ family
UWK_RS17330	COG1704	LemA family
UWK_RS17335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
UWK_RS17340	COG2255	four-way junction helicase activity
UWK_RS17345	COG0632	four-way junction helicase activity
UWK_RS17350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
UWK_RS17355	COG0217	transcriptional regulatory protein
UWK_RS17360	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
UWK_RS17365	COG0617	tRNA 3'-terminal CCA addition
UWK_RS17380	COG1213	nucleotidyl transferase
UWK_RS17385	COG3494	Protein of unknown function (DUF1009)
UWK_RS17390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UWK_RS17395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
UWK_RS17400	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UWK_RS17405	COG3876	Protein conserved in bacteria
UWK_RS17410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
UWK_RS17415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
UWK_RS17430	COG0436	Aminotransferase
UWK_RS17455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UWK_RS17480	COG1518	maintenance of DNA repeat elements
UWK_RS17520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UWK_RS17525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
UWK_RS17535	COG1136	(ABC) transporter
UWK_RS17540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
UWK_RS17545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UWK_RS17550	COG0473	3-isopropylmalate dehydrogenase activity
UWK_RS17570	COG0357	Ribosomal RNA small subunit methyltransferase G
UWK_RS17575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
UWK_RS17585	COG0017	Asparaginyl-tRNA synthetase
UWK_RS17610	COG0131	Imidazoleglycerol-phosphate dehydratase
UWK_RS17620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
UWK_RS17625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UWK_RS17630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
UWK_RS17635	COG0101	tRNA pseudouridine synthase activity
UWK_RS17645	COG0583	DNA-binding transcription factor activity
UWK_RS17650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UWK_RS17655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UWK_RS17660	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UWK_RS17665	COG0649	NAD binding
UWK_RS17670	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
UWK_RS17675	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UWK_RS17680	COG0839	Belongs to the complex I subunit 6 family
UWK_RS17685	COG0713	ATP synthesis coupled electron transport
UWK_RS17690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UWK_RS17700	COG0651	ATP synthesis coupled electron transport
UWK_RS17710	COG1007	ATP synthesis coupled electron transport
UWK_RS17960	COG1388	LysM domain
UWK_RS17960	COG0791	NLP P60 protein
UWK_RS17975	COG0745	RESPONSE REGULATOR receiver
UWK_RS17990	COG0784	Response regulator, receiver
UWK_RS17990	COG4191	Histidine kinase
UWK_RS18005	COG0655	NAD(P)H dehydrogenase (quinone) activity
UWK_RS18025	COG1450	Type ii and iii secretion system protein
UWK_RS18060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
UWK_RS18080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UWK_RS18080	COG4191	Histidine kinase
UWK_RS18090	COG0739	heme binding
UWK_RS18110	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
UWK_RS18110	COG3264	Mechanosensitive ion channel
UWK_RS18120	COG0668	transmembrane transport
UWK_RS18125	COG0840	transmembrane signaling receptor activity
UWK_RS18130	COG0741	lytic transglycosylase activity
UWK_RS18135	COG4191	Histidine kinase
UWK_RS18135	COG0784	Response regulator, receiver
UWK_RS18150	COG3852	Histidine kinase
UWK_RS18185	COG2205	protein histidine kinase activity
UWK_RS18205	COG1090	epimerase
UWK_RS18245	COG2304	oxidoreductase activity
UWK_RS18260	COG2885	chlorophyll binding
UWK_RS18280	COG1366	Belongs to the anti-sigma-factor antagonist family
UWK_RS18290	COG5002	protein histidine kinase activity
UWK_RS18310	COG3706	GGDEF domain
UWK_RS18335	COG5002	protein histidine kinase activity
UWK_RS18350	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
UWK_RS18350	COG2199	diguanylate cyclase activity
UWK_RS18365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UWK_RS18400	COG4999	Histidine kinase
UWK_RS18400	COG2205	protein histidine kinase activity
UWK_RS18400	COG3437	response regulator, receiver
UWK_RS18400	COG3850	Histidine kinase
UWK_RS18405	COG0584	glycerophosphoryl diester phosphodiesterase
UWK_RS18410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UWK_RS18450	COG1686	Belongs to the peptidase S11 family
UWK_RS18465	COG1573	uracil-dna glycosylase
UWK_RS18495	COG4251	negative regulation of phosphorylation
UWK_RS18525	COG0438	transferase activity, transferring glycosyl groups
UWK_RS18525	COG1216	Glycosyl transferase, family 2
UWK_RS18540	COG4589	Belongs to the CDS family
UWK_RS18550	COG3706	GGDEF domain
UWK_RS18575	COG1216	Glycosyl transferase, family 2
UWK_RS18575	COG1442	glycosyl transferase family 8
UWK_RS18585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UWK_RS18590	COG3852	Histidine kinase
UWK_RS18600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UWK_RS18600	COG2755	lipolytic protein G-D-S-L family
UWK_RS18650	COG0515	serine threonine protein kinase
UWK_RS18650	COG2815	serine threonine protein kinase
UWK_RS18655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UWK_RS18655	COG4191	Histidine kinase
UWK_RS18665	COG2201	protein-glutamate methylesterase activity
UWK_RS18670	COG2199	diguanylate cyclase activity
UWK_RS18670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
UWK_RS18710	COG3706	GGDEF domain
UWK_RS18715	COG0826	peptidase U32
UWK_RS18720	COG2205	protein histidine kinase activity
UWK_RS18720	COG0784	Response regulator, receiver
UWK_RS18725	COG0437	4 iron, 4 sulfur cluster binding
UWK_RS18740	COG5002	protein histidine kinase activity
UWK_RS18745	COG3706	GGDEF domain
UWK_RS18750	COG1419	protein localization to endoplasmic reticulum
UWK_RS18800	COG4191	Histidine kinase
UWK_RS18810	COG1216	Glycosyl transferase, family 2
UWK_RS18815	COG2205	protein histidine kinase activity
UWK_RS18815	COG3437	response regulator, receiver
UWK_RS18815	COG3850	Histidine kinase
UWK_RS18815	COG4999	Histidine kinase
UWK_RS18820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly