locus-tag	class	description
DESAF_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DESAF_RS00015	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DESAF_RS00025	COG0632	four-way junction helicase activity
DESAF_RS00030	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DESAF_RS00035	COG0217	transcriptional regulatory protein
DESAF_RS00040	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DESAF_RS00075	COG0243	molybdopterin cofactor binding
DESAF_RS00095	COG2201	protein-glutamate methylesterase activity
DESAF_RS00115	COG0463	Glycosyl transferase, family 2
DESAF_RS00125	COG0463	Glycosyl transferase, family 2
DESAF_RS00140	COG0402	S-adenosylhomocysteine deaminase activity
DESAF_RS00150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DESAF_RS00155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DESAF_RS00160	COG0494	nUDIX hydrolase
DESAF_RS00170	COG0488	(ABC) transporter
DESAF_RS00180	COG2226	methyltransferase
DESAF_RS00195	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DESAF_RS00200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DESAF_RS00240	COG0724	RNA recognition motif
DESAF_RS00260	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DESAF_RS00275	COG0697	spore germination
DESAF_RS00290	COG2207	Transcriptional regulator
DESAF_RS00305	COG0385	Bile acid
DESAF_RS00315	COG0658	competence protein
DESAF_RS00315	COG2333	competence protein COMEC
DESAF_RS00355	COG1362	aminopeptidase activity
DESAF_RS00360	COG1921	L-seryl-tRNASec selenium transferase activity
DESAF_RS00365	COG0285	dihydrofolate synthase activity
DESAF_RS00370	COG2208	phosphoserine phosphatase activity
DESAF_RS00380	COG1028	Short-chain dehydrogenase reductase Sdr
DESAF_RS00405	COG4134	Bacterial extracellular solute-binding protein
DESAF_RS00410	COG3842	ATPase activity
DESAF_RS00430	COG3387	PFAM Glycoside hydrolase 15-related
DESAF_RS00435	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DESAF_RS00440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DESAF_RS00445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DESAF_RS00450	COG0363	glucosamine-6-phosphate deaminase activity
DESAF_RS00470	COG0488	(ABC) transporter
DESAF_RS00495	COG1053	succinate dehydrogenase
DESAF_RS00500	COG0471	metal ion transport
DESAF_RS00510	COG0459	protein refolding
DESAF_RS00515	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DESAF_RS00540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DESAF_RS00540	COG0517	IMP dehydrogenase activity
DESAF_RS00545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DESAF_RS00555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DESAF_RS00585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DESAF_RS00590	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DESAF_RS00595	COG1419	protein localization to endoplasmic reticulum
DESAF_RS00605	COG1191	sigma factor activity
DESAF_RS00635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DESAF_RS00640	COG0784	Response regulator, receiver
DESAF_RS00640	COG0835	chemotaxis
DESAF_RS00650	COG0409	Hydrogenase expression formation protein
DESAF_RS00660	COG1666	GTP binding
DESAF_RS00675	COG1181	Belongs to the D-alanine--D-alanine ligase family
DESAF_RS00680	COG1519	Transferase
DESAF_RS00680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DESAF_RS00685	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DESAF_RS00700	COG2089	acid synthase
DESAF_RS00710	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DESAF_RS00715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DESAF_RS00725	COG0297	glycogen (starch) synthase activity
DESAF_RS00730	COG0494	nUDIX hydrolase
DESAF_RS00740	COG0009	L-threonylcarbamoyladenylate synthase
DESAF_RS00745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DESAF_RS00750	COG4822	anaerobic cobalamin biosynthetic process
DESAF_RS00755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DESAF_RS00760	COG1120	ATPase activity
DESAF_RS00780	COG0756	dUTP diphosphatase activity
DESAF_RS00785	COG0058	SHG alpha-glucan phosphorylase activity
DESAF_RS00790	COG0693	protein deglycase activity
DESAF_RS00795	COG0840	transmembrane signaling receptor activity
DESAF_RS00800	COG3678	ATP-independent chaperone mediated protein folding
DESAF_RS00805	COG1598	PFAM Uncharacterised protein family UPF0150
DESAF_RS00815	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DESAF_RS00835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DESAF_RS00865	COG0233	cytoplasmic translational termination
DESAF_RS00870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DESAF_RS00875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DESAF_RS00880	COG0348	domain, Protein
DESAF_RS00895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DESAF_RS00935	COG1657	PFAM Prenyltransferase squalene oxidase
DESAF_RS00955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DESAF_RS00970	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DESAF_RS00985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DESAF_RS00990	COG1459	type II secretion system
DESAF_RS01015	COG3156	type II secretion system protein K
DESAF_RS01030	COG1450	Type ii and iii secretion system protein
DESAF_RS01035	COG0514	ATP-dependent DNA helicase (RecQ)
DESAF_RS01055	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DESAF_RS01060	COG1127	ABC transporter
DESAF_RS01065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DESAF_RS01080	COG0586	Pfam SNARE associated Golgi protein
DESAF_RS01085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DESAF_RS01090	COG0085	RNA polymerase activity
DESAF_RS01095	COG0222	ribosome binding
DESAF_RS01100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DESAF_RS01105	COG0081	regulation of translation
DESAF_RS01110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DESAF_RS01115	COG0250	Participates in transcription elongation, termination and antitermination
DESAF_RS01120	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DESAF_RS01160	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DESAF_RS01165	COG2890	protein-(glutamine-N5) methyltransferase activity
DESAF_RS01170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DESAF_RS01175	COG3872	metal-dependent enzyme
DESAF_RS01180	COG0254	rRNA binding
DESAF_RS01185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DESAF_RS01190	COG0588	phosphoglycerate mutase activity
DESAF_RS01195	COG1194	a g-specific adenine glycosylase
DESAF_RS01205	COG1472	Belongs to the glycosyl hydrolase 3 family
DESAF_RS01215	COG0167	dihydroorotate dehydrogenase activity
DESAF_RS01220	COG0543	2 iron, 2 sulfur cluster binding
DESAF_RS01225	COG0826	peptidase U32
DESAF_RS01230	COG0583	DNA-binding transcription factor activity
DESAF_RS01240	COG0697	spore germination
DESAF_RS01250	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DESAF_RS01260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DESAF_RS01270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DESAF_RS01290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DESAF_RS01295	COG0662	Cupin 2, conserved barrel domain protein
DESAF_RS01300	COG0151	Belongs to the GarS family
DESAF_RS01320	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DESAF_RS01325	COG0840	transmembrane signaling receptor activity
DESAF_RS01350	COG0655	NAD(P)H dehydrogenase (quinone) activity
DESAF_RS01380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DESAF_RS01405	COG2198	Histidine kinase
DESAF_RS01405	COG5002	protein histidine kinase activity
DESAF_RS01405	COG0784	Response regulator, receiver
DESAF_RS01450	COG4191	Histidine kinase
DESAF_RS01465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DESAF_RS01470	COG0569	domain protein
DESAF_RS01475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DESAF_RS01510	COG0488	(ABC) transporter
DESAF_RS01520	COG3959	Transketolase, thiamine diphosphate binding domain
DESAF_RS01525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DESAF_RS01530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DESAF_RS01535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DESAF_RS01565	COG1573	uracil-dna glycosylase
DESAF_RS01585	COG1837	Belongs to the UPF0109 family
DESAF_RS01600	COG0045	succinate-CoA ligase (ADP-forming) activity
DESAF_RS01600	COG1042	CoA-binding domain protein
DESAF_RS01600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DESAF_RS01605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DESAF_RS01660	COG0411	ABC transporter
DESAF_RS01680	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DESAF_RS01705	COG2046	Belongs to the sulfate adenylyltransferase family
DESAF_RS01720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DESAF_RS01725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DESAF_RS01735	COG0622	Phosphoesterase
DESAF_RS01745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DESAF_RS01775	COG2155	Conserved Protein
DESAF_RS01795	COG0521	Mo-molybdopterin cofactor biosynthetic process
DESAF_RS01800	COG0784	Response regulator, receiver
DESAF_RS01800	COG2205	protein histidine kinase activity
DESAF_RS01805	COG0745	RESPONSE REGULATOR receiver
DESAF_RS01810	COG1191	sigma factor activity
DESAF_RS01820	COG5002	protein histidine kinase activity
DESAF_RS01820	COG2198	Histidine kinase
DESAF_RS01820	COG0784	Response regulator, receiver
DESAF_RS01845	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DESAF_RS01850	COG1749	Flagellar hook protein flgE
DESAF_RS01855	COG1256	bacterial-type flagellum assembly
DESAF_RS01865	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DESAF_RS01915	COG5654	RES domain protein
DESAF_RS01940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DESAF_RS01945	COG0842	Transport permease protein
DESAF_RS01950	COG0842	Transport permease protein
DESAF_RS01955	COG1131	(ABC) transporter
DESAF_RS01960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESAF_RS01965	COG1309	transcriptional regulator
DESAF_RS01975	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DESAF_RS01990	COG0071	Belongs to the small heat shock protein (HSP20) family
DESAF_RS02015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DESAF_RS02025	COG2226	methyltransferase
DESAF_RS02065	COG0437	4 iron, 4 sulfur cluster binding
DESAF_RS02090	COG4302	ethanolamine ammonia-lyase activity
DESAF_RS02095	COG4303	Ethanolamine ammonia lyase large subunit
DESAF_RS02175	COG0582	viral genome integration into host DNA
DESAF_RS02185	COG0702	epimerase
DESAF_RS02195	COG2855	membrane
DESAF_RS02200	COG2204	response regulator
DESAF_RS02210	COG2855	membrane
DESAF_RS02220	COG3852	Histidine kinase
DESAF_RS02240	COG0247	lactate metabolic process
DESAF_RS02245	COG2181	nitrate reductase activity
DESAF_RS02255	COG1132	(ABC) transporter
DESAF_RS02270	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DESAF_RS02275	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DESAF_RS02280	COG0731	radical SAM domain protein
DESAF_RS02280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DESAF_RS02285	COG1530	ribonuclease E activity
DESAF_RS02290	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DESAF_RS02305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DESAF_RS02330	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DESAF_RS02335	COG0148	phosphopyruvate hydratase activity
DESAF_RS02360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DESAF_RS02400	COG1136	(ABC) transporter
DESAF_RS02400	COG0577	efflux transmembrane transporter activity
DESAF_RS02405	COG0577	efflux transmembrane transporter activity
DESAF_RS02405	COG1136	(ABC) transporter
DESAF_RS02410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DESAF_RS02425	COG0330	HflC and HflK could
DESAF_RS02430	COG0330	HflC and HflK could
DESAF_RS02440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DESAF_RS02465	COG3153	acetyltransferase
DESAF_RS02470	COG1295	ribonuclease BN
DESAF_RS02470	COG1959	2 iron, 2 sulfur cluster binding
DESAF_RS02480	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DESAF_RS02490	COG0436	Aminotransferase
DESAF_RS02510	COG0336	Belongs to the RNA methyltransferase TrmD family
DESAF_RS02510	COG4752	Belongs to the RNA methyltransferase TrmD family
DESAF_RS02525	COG1837	Belongs to the UPF0109 family
DESAF_RS02530	COG0228	four-way junction DNA binding
DESAF_RS02535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DESAF_RS02565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DESAF_RS02580	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DESAF_RS02590	COG2205	protein histidine kinase activity
DESAF_RS02600	COG1295	ribonuclease BN
DESAF_RS02610	COG3267	Type II secretory pathway component ExeA
DESAF_RS02610	COG3409	Peptidoglycan-binding domain 1 protein
DESAF_RS02660	COG1271	oxidase subunit
DESAF_RS02665	COG1294	oxidase, subunit
DESAF_RS02680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DESAF_RS02695	COG1166	arginine decarboxylase activity
DESAF_RS02715	COG2132	Multicopper oxidase
DESAF_RS02720	COG1748	Saccharopine dehydrogenase
DESAF_RS02750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DESAF_RS02755	COG0129	dihydroxy-acid dehydratase activity
DESAF_RS02785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DESAF_RS02830	COG1196	nuclear chromosome segregation
DESAF_RS02840	COG2890	protein-(glutamine-N5) methyltransferase activity
DESAF_RS02855	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DESAF_RS02860	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DESAF_RS02865	COG0745	RESPONSE REGULATOR receiver
DESAF_RS02875	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DESAF_RS02885	COG0649	NAD binding
DESAF_RS02895	COG3260	NADH ubiquinone oxidoreductase 20
DESAF_RS02905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DESAF_RS02905	COG2111	Na H antiporter
DESAF_RS02930	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DESAF_RS02955	COG0039	L-malate dehydrogenase activity
DESAF_RS02965	COG0471	metal ion transport
DESAF_RS03005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DESAF_RS03025	COG1773	rubredoxin
DESAF_RS03055	COG1454	alcohol dehydrogenase
DESAF_RS03070	COG1067	ATP-dependent peptidase activity
DESAF_RS03085	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DESAF_RS03130	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
DESAF_RS03145	COG0438	transferase activity, transferring glycosyl groups
DESAF_RS03160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DESAF_RS03160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DESAF_RS03165	COG0181	hydroxymethylbilane synthase activity
DESAF_RS03180	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DESAF_RS03200	COG1083	cytidylyl-transferase
DESAF_RS03240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESAF_RS03250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DESAF_RS03255	COG0601	transmembrane transport
DESAF_RS03400	COG0640	Transcriptional regulator
DESAF_RS03410	COG4373	Mu-like prophage FluMu protein gp28
DESAF_RS03415	COG4383	Mu-like prophage protein gp29
DESAF_RS03435	COG4397	Mu-like prophage major head subunit gpT
DESAF_RS03470	COG4386	tail sheath protein
DESAF_RS03505	COG4384	Bacteriophage Mu Gp45 protein
DESAF_RS03515	COG3299	homolog of phage Mu protein gp47
DESAF_RS03580	COG3852	Histidine kinase
DESAF_RS03585	COG2204	response regulator
DESAF_RS03590	COG4191	Histidine kinase
DESAF_RS03600	COG3848	Pyruvate phosphate dikinase
DESAF_RS03600	COG0574	Belongs to the PEP-utilizing enzyme family
DESAF_RS03635	COG0840	transmembrane signaling receptor activity
DESAF_RS03650	COG1215	transferase activity, transferring glycosyl groups
DESAF_RS03655	COG0438	transferase activity, transferring glycosyl groups
DESAF_RS03675	COG1215	transferase activity, transferring glycosyl groups
DESAF_RS03690	COG3267	Type II secretory pathway component ExeA
DESAF_RS03690	COG3409	Peptidoglycan-binding domain 1 protein
DESAF_RS03720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DESAF_RS03730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DESAF_RS03740	COG0356	it plays a direct role in the translocation of protons across the membrane
DESAF_RS03760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DESAF_RS03775	COG5002	protein histidine kinase activity
DESAF_RS03800	COG0438	transferase activity, transferring glycosyl groups
DESAF_RS03800	COG1216	Glycosyl transferase, family 2
DESAF_RS03820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESAF_RS03825	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
DESAF_RS03830	COG0347	Belongs to the P(II) protein family
DESAF_RS03880	COG1082	Xylose isomerase domain protein TIM barrel
DESAF_RS03885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESAF_RS03885	COG2205	protein histidine kinase activity
DESAF_RS03905	COG2197	response regulator
DESAF_RS03935	COG1803	Methylglyoxal synthase
DESAF_RS03955	COG5001	Diguanylate cyclase
DESAF_RS03965	COG0857	belongs to the CobB CobQ family
DESAF_RS03970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DESAF_RS03970	COG0045	succinate-CoA ligase (ADP-forming) activity
DESAF_RS03970	COG1042	CoA-binding domain protein
DESAF_RS03975	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DESAF_RS04020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DESAF_RS04025	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DESAF_RS04030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DESAF_RS04045	COG0072	phenylalanine-tRNA ligase activity
DESAF_RS04045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DESAF_RS04060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DESAF_RS04095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DESAF_RS04100	COG0444	Belongs to the ABC transporter superfamily
DESAF_RS04105	COG4608	Belongs to the ABC transporter superfamily
DESAF_RS04115	COG0412	Dienelactone hydrolase
DESAF_RS04125	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DESAF_RS04130	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DESAF_RS04150	COG1067	ATP-dependent peptidase activity
DESAF_RS04155	COG2814	Major facilitator Superfamily
DESAF_RS04170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESAF_RS04185	COG4753	response regulator
DESAF_RS04185	COG2207	Transcriptional regulator
DESAF_RS04190	COG2207	Transcriptional regulator
DESAF_RS04190	COG4753	response regulator
DESAF_RS04195	COG0012	GTP binding
DESAF_RS04230	COG0537	adenosine 5'-monophosphoramidase activity
DESAF_RS04240	COG0540	Belongs to the ATCase OTCase family
DESAF_RS04260	COG0071	Belongs to the small heat shock protein (HSP20) family
DESAF_RS04270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESAF_RS04285	COG1970	mechanosensitive ion channel activity
DESAF_RS04295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DESAF_RS04305	COG0398	Pfam SNARE associated Golgi protein
DESAF_RS04310	COG0497	DNA recombination
DESAF_RS04330	COG0640	Transcriptional regulator
DESAF_RS04340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESAF_RS04340	COG2205	protein histidine kinase activity
DESAF_RS04365	COG0745	RESPONSE REGULATOR receiver
DESAF_RS04370	COG5002	protein histidine kinase activity
DESAF_RS04375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DESAF_RS04380	COG0704	Plays a role in the regulation of phosphate uptake
DESAF_RS04390	COG0840	transmembrane signaling receptor activity
DESAF_RS04410	COG2076	Multidrug Resistance protein
DESAF_RS04415	COG1606	tRNA processing
DESAF_RS04420	COG0456	acetyltransferase
DESAF_RS04450	COG2165	general secretion pathway protein
DESAF_RS04455	COG1459	type II secretion system
DESAF_RS04465	COG3267	Type II secretory pathway component ExeA
DESAF_RS04465	COG3409	Peptidoglycan-binding domain 1 protein
DESAF_RS04490	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DESAF_RS04495	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DESAF_RS04525	COG0243	molybdopterin cofactor binding
DESAF_RS04540	COG0535	radical SAM domain protein
DESAF_RS04540	COG1433	Dinitrogenase iron-molybdenum cofactor
DESAF_RS04585	COG4221	oxidoreductase activity
DESAF_RS04590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESAF_RS04595	COG1132	(ABC) transporter
DESAF_RS04600	COG2205	protein histidine kinase activity
DESAF_RS04600	COG0784	Response regulator, receiver
DESAF_RS04610	COG1607	acyl-coa hydrolase
DESAF_RS04625	COG2217	Heavy metal translocating P-type atpase
DESAF_RS04630	COG1640	4-alpha-glucanotransferase
DESAF_RS04635	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
DESAF_RS04645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DESAF_RS04650	COG0326	Molecular chaperone. Has ATPase activity
DESAF_RS04665	COG0583	DNA-binding transcription factor activity
DESAF_RS04705	COG0577	efflux transmembrane transporter activity
DESAF_RS04705	COG1136	(ABC) transporter
DESAF_RS04750	COG1280	lysine exporter protein (LysE YggA)
DESAF_RS04765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DESAF_RS04765	COG1918	ferrous iron import across plasma membrane
DESAF_RS04795	COG0606	chelatase, subunit chli
DESAF_RS04800	COG0471	metal ion transport
DESAF_RS04805	COG2204	response regulator
DESAF_RS04810	COG4191	Histidine kinase
DESAF_RS04810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESAF_RS04815	COG0606	chelatase, subunit chli
DESAF_RS04825	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DESAF_RS04830	COG2200	EAL domain
DESAF_RS04835	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DESAF_RS04840	COG2226	methyltransferase
DESAF_RS04845	COG2204	response regulator
DESAF_RS04850	COG3852	Histidine kinase
DESAF_RS04870	COG0668	transmembrane transport
DESAF_RS04880	COG0840	transmembrane signaling receptor activity
DESAF_RS04890	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
DESAF_RS04895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DESAF_RS04915	COG0395	ABC-type sugar transport system, permease component
DESAF_RS04920	COG1175	transmembrane transport
DESAF_RS04930	COG3842	ATPase activity
DESAF_RS04945	COG0156	8-amino-7-oxononanoate synthase activity
DESAF_RS04950	COG2226	methyltransferase
DESAF_RS04950	COG1073	alpha beta
DESAF_RS04955	COG4106	trans-aconitate 2-methyltransferase activity
DESAF_RS04960	COG0352	thiamine-phosphate diphosphorylase activity
DESAF_RS04965	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
DESAF_RS04975	COG0318	PFAM AMP-dependent synthetase and ligase
DESAF_RS05005	COG1151	hydroxylamine reductase activity
DESAF_RS05010	COG1151	hydroxylamine reductase activity
DESAF_RS05015	COG0303	'Molybdopterin
DESAF_RS05020	COG0110	maltose O-acetyltransferase activity
DESAF_RS05025	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DESAF_RS05040	COG2078	PFAM AMMECR1 domain protein
DESAF_RS05045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DESAF_RS05060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DESAF_RS05080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DESAF_RS05085	COG1247	-acetyltransferase
DESAF_RS05105	COG1132	(ABC) transporter
DESAF_RS05135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DESAF_RS05140	COG0390	transport system, permease component
DESAF_RS05180	COG0438	transferase activity, transferring glycosyl groups
DESAF_RS05195	COG0481	GTPase activity
DESAF_RS05220	COG1785	Belongs to the alkaline phosphatase family
DESAF_RS05245	COG3005	denitrification pathway
DESAF_RS05280	COG0306	phosphate transporter
DESAF_RS05305	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DESAF_RS05315	COG1121	(ABC) transporter
DESAF_RS05320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DESAF_RS05335	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DESAF_RS05350	COG0101	tRNA pseudouridine synthase activity
DESAF_RS05355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DESAF_RS05360	COG0724	RNA recognition motif
DESAF_RS05370	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DESAF_RS05370	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DESAF_RS05375	COG1475	DNA binding
DESAF_RS05395	COG0330	HflC and HflK could
DESAF_RS05410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DESAF_RS05420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DESAF_RS05430	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DESAF_RS05430	COG0674	pyruvate-flavodoxin oxidoreductase activity
DESAF_RS05470	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DESAF_RS05485	COG0501	Belongs to the peptidase M48B family
DESAF_RS05500	COG0406	alpha-ribazole phosphatase activity
DESAF_RS05520	COG0577	efflux transmembrane transporter activity
DESAF_RS05520	COG1136	(ABC) transporter
DESAF_RS05535	COG4957	zinc ion binding
DESAF_RS05550	COG0840	transmembrane signaling receptor activity
DESAF_RS05555	COG2198	Histidine kinase
DESAF_RS05555	COG5002	protein histidine kinase activity
DESAF_RS05555	COG0784	Response regulator, receiver
DESAF_RS05560	COG0724	RNA recognition motif
DESAF_RS05575	COG1509	lysine 2,3-aminomutase activity
DESAF_RS05580	COG1126	abc transporter atp-binding protein
DESAF_RS05590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESAF_RS05595	COG0166	Belongs to the GPI family
DESAF_RS05650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DESAF_RS05650	COG0512	Glutamine amidotransferase of anthranilate synthase
DESAF_RS05665	COG5002	protein histidine kinase activity
DESAF_RS05670	COG5002	protein histidine kinase activity
DESAF_RS05675	COG0745	RESPONSE REGULATOR receiver
DESAF_RS05685	COG2815	serine threonine protein kinase
DESAF_RS05685	COG0515	serine threonine protein kinase
DESAF_RS05690	COG2205	protein histidine kinase activity
DESAF_RS05690	COG0784	Response regulator, receiver
DESAF_RS05705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DESAF_RS05710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DESAF_RS05725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DESAF_RS05745	COG1215	transferase activity, transferring glycosyl groups
DESAF_RS05775	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DESAF_RS05780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DESAF_RS05800	COG3852	Histidine kinase
DESAF_RS05845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DESAF_RS05850	COG0741	lytic transglycosylase activity
DESAF_RS05850	COG1388	LysM domain
DESAF_RS05855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DESAF_RS05860	COG1987	bacterial-type flagellum assembly
DESAF_RS05865	COG1338	Plays a role in the flagellum-specific transport system
DESAF_RS05905	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DESAF_RS05910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DESAF_RS05915	COG0288	reversible hydration of carbon dioxide
DESAF_RS05920	COG0745	RESPONSE REGULATOR receiver
DESAF_RS05930	COG2204	response regulator
DESAF_RS05950	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DESAF_RS05960	COG0187	DNA topoisomerase II activity
DESAF_RS05965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DESAF_RS05985	COG0683	leucine binding
DESAF_RS05990	COG0564	pseudouridine synthase activity
DESAF_RS06000	COG2884	Cell division ATP-binding protein ftsE
DESAF_RS06005	COG2177	Part of the ABC transporter FtsEX involved in
DESAF_RS06015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DESAF_RS06020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DESAF_RS06025	COG0737	Belongs to the 5'-nucleotidase family
DESAF_RS06030	COG0840	transmembrane signaling receptor activity
DESAF_RS06040	COG2026	Addiction module toxin, RelE StbE family
DESAF_RS06060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESAF_RS06075	COG3681	Belongs to the UPF0597 family
DESAF_RS06085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DESAF_RS06110	COG2204	response regulator
DESAF_RS06115	COG5002	protein histidine kinase activity
DESAF_RS06125	COG1216	Glycosyl transferase, family 2
DESAF_RS06155	COG1459	type II secretion system
DESAF_RS06190	COG3156	type II secretion system protein K
DESAF_RS06215	COG1309	transcriptional regulator
DESAF_RS06225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DESAF_RS06235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DESAF_RS06240	COG0277	FAD linked oxidase domain protein
DESAF_RS06260	COG1131	(ABC) transporter
DESAF_RS06270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DESAF_RS06275	COG3845	ABC transporter
DESAF_RS06280	COG1079	Belongs to the binding-protein-dependent transport system permease family
DESAF_RS06285	COG0024	Methionine aminopeptidase
DESAF_RS06290	COG4603	Belongs to the binding-protein-dependent transport system permease family
DESAF_RS06300	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DESAF_RS06305	COG1012	belongs to the aldehyde dehydrogenase family
DESAF_RS06310	COG1245	4Fe-4S binding domain
DESAF_RS06310	COG2878	Part of a membrane complex involved in electron transport
DESAF_RS06320	COG4662	Binding-protein-dependent transport system inner membrane component
DESAF_RS06330	COG1032	radical SAM domain protein
DESAF_RS06335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DESAF_RS06340	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DESAF_RS06345	COG1045	serine acetyltransferase
DESAF_RS06380	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DESAF_RS06390	COG2119	membrane
DESAF_RS06420	COG1929	Belongs to the glycerate kinase type-1 family
DESAF_RS06450	COG0840	transmembrane signaling receptor activity
DESAF_RS06455	COG0004	ammonium transporteR
DESAF_RS06460	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DESAF_RS06475	COG1111	helicase
DESAF_RS06475	COG1205	dead DEAH box helicase
DESAF_RS06500	COG0640	Transcriptional regulator
DESAF_RS06505	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DESAF_RS06565	COG0463	Glycosyl transferase, family 2
DESAF_RS06585	COG3608	succinylglutamate desuccinylase aspartoacylase
DESAF_RS06585	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DESAF_RS06595	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DESAF_RS06600	COG1842	Phage shock protein A
DESAF_RS06640	COG0686	Belongs to the AlaDH PNT family
DESAF_RS06650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DESAF_RS06660	COG1022	Amp-dependent synthetase and ligase
DESAF_RS06680	COG2124	cytochrome p450
DESAF_RS06690	COG1131	(ABC) transporter
DESAF_RS06715	COG1659	Linocin_M18 bacteriocin protein
DESAF_RS06720	COG0840	transmembrane signaling receptor activity
DESAF_RS06745	COG0723	plastoquinol--plastocyanin reductase activity
DESAF_RS06745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DESAF_RS06755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DESAF_RS06765	COG0438	transferase activity, transferring glycosyl groups
DESAF_RS06795	COG0500	methyltransferase
DESAF_RS06805	COG2264	protein methyltransferase activity
DESAF_RS06810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DESAF_RS06815	COG1260	myo-inositol-1-phosphate synthase
DESAF_RS06820	COG5002	protein histidine kinase activity
DESAF_RS06850	COG2221	Nitrite and sulphite reductase 4Fe-4S
DESAF_RS06855	COG2221	Nitrite and sulphite reductase 4Fe-4S
DESAF_RS06865	COG1797	cobyrinic acid a,c-diamide synthase activity
DESAF_RS06885	COG0429	hydrolase of the alpha beta-hydrolase fold
DESAF_RS06890	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DESAF_RS06900	COG1032	radical SAM domain protein
DESAF_RS06935	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DESAF_RS06945	COG3279	Response regulator of the LytR AlgR family
DESAF_RS06950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DESAF_RS06955	COG0367	asparagine synthase
DESAF_RS06975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DESAF_RS06975	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DESAF_RS07035	COG0671	phosphoesterase, PA-phosphatase related
DESAF_RS07055	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DESAF_RS07065	COG1847	R3H domain protein
DESAF_RS07080	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DESAF_RS07100	COG0598	Magnesium transport protein CorA
DESAF_RS07120	COG1592	Rubrerythrin
DESAF_RS07125	COG0735	belongs to the Fur family
DESAF_RS07130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DESAF_RS07130	COG1328	CTP reductase activity
DESAF_RS07165	COG0784	Response regulator, receiver
DESAF_RS07165	COG2205	protein histidine kinase activity
DESAF_RS07165	COG5002	protein histidine kinase activity
DESAF_RS07170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DESAF_RS07170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DESAF_RS07200	COG2201	protein-glutamate methylesterase activity
DESAF_RS07215	COG0745	RESPONSE REGULATOR receiver
DESAF_RS07225	COG0107	imidazoleglycerol-phosphate synthase activity
DESAF_RS07230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DESAF_RS07250	COG1304	FMN binding
DESAF_RS07265	COG0525	valine-tRNA ligase activity
DESAF_RS07290	COG1489	DNA binding
DESAF_RS07295	COG0346	lactoylglutathione lyase activity
DESAF_RS07340	COG2204	response regulator
DESAF_RS07345	COG2204	response regulator
DESAF_RS07395	COG0437	4 iron, 4 sulfur cluster binding
DESAF_RS07400	COG1937	Protein conserved in bacteria
DESAF_RS07430	COG0437	4 iron, 4 sulfur cluster binding
DESAF_RS07435	COG0243	molybdopterin cofactor binding
DESAF_RS07450	COG2204	response regulator
DESAF_RS07455	COG4191	Histidine kinase
DESAF_RS07460	COG4166	transmembrane transport
DESAF_RS07480	COG0135	phosphoribosylanthranilate isomerase activity
DESAF_RS07495	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DESAF_RS07520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DESAF_RS07520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DESAF_RS07525	COG0303	'Molybdopterin
DESAF_RS07545	COG1942	4-Oxalocrotonate Tautomerase
DESAF_RS07555	COG0671	phosphoesterase, PA-phosphatase related
DESAF_RS07575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DESAF_RS07575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DESAF_RS07590	COG0242	peptide deformylase activity
DESAF_RS07595	COG0730	response to heat
DESAF_RS07605	COG1950	PFAM Membrane protein of
DESAF_RS07610	COG1012	belongs to the aldehyde dehydrogenase family
DESAF_RS07615	COG1522	sequence-specific DNA binding
DESAF_RS07620	COG1566	PFAM secretion protein HlyD family protein
DESAF_RS07625	COG2814	Major facilitator Superfamily
DESAF_RS07635	COG3830	Belongs to the UPF0237 family
DESAF_RS07635	COG0560	Phosphoserine phosphatase
DESAF_RS07695	COG1013	pyruvate-flavodoxin oxidoreductase activity
DESAF_RS07715	COG0534	Mate efflux family protein
DESAF_RS07725	COG0432	Pfam Uncharacterised protein family UPF0047
DESAF_RS07750	COG1959	2 iron, 2 sulfur cluster binding
DESAF_RS07755	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DESAF_RS07755	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DESAF_RS07765	COG0004	ammonium transporteR
DESAF_RS07780	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DESAF_RS07800	COG2247	cell wall binding repeat
DESAF_RS07800	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESAF_RS07805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DESAF_RS07810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DESAF_RS07820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESAF_RS07825	COG0539	negative regulation of cytoplasmic translation
DESAF_RS07825	COG2183	response to ionizing radiation
DESAF_RS07830	COG0616	signal peptide processing
DESAF_RS07840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DESAF_RS07845	COG1242	4 iron, 4 sulfur cluster binding
DESAF_RS07850	COG1077	Cell shape determining protein MreB Mrl
DESAF_RS07865	COG0768	penicillin binding
DESAF_RS07870	COG0772	Belongs to the SEDS family
DESAF_RS07880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DESAF_RS07890	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DESAF_RS07895	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DESAF_RS07900	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DESAF_RS07910	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DESAF_RS07915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DESAF_RS07935	COG0659	secondary active sulfate transmembrane transporter activity
DESAF_RS07940	COG1692	metallophosphoesterase
DESAF_RS07960	COG0109	protoheme IX farnesyltransferase activity
DESAF_RS07965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DESAF_RS07985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DESAF_RS07990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DESAF_RS07995	COG0277	FAD linked oxidase domain protein
DESAF_RS08005	COG0653	protein targeting
DESAF_RS08020	COG0569	domain protein
DESAF_RS08025	COG0517	IMP dehydrogenase activity
DESAF_RS08030	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DESAF_RS08050	COG1140	nitrate reductase beta subunit
DESAF_RS08055	COG1007	ATP synthesis coupled electron transport
DESAF_RS08065	COG0651	ATP synthesis coupled electron transport
DESAF_RS08075	COG0651	ATP synthesis coupled electron transport
DESAF_RS08080	COG0713	ATP synthesis coupled electron transport
DESAF_RS08090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESAF_RS08095	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DESAF_RS08100	COG0649	NAD binding
DESAF_RS08105	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESAF_RS08110	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESAF_RS08115	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESAF_RS08120	COG0243	molybdopterin cofactor binding
DESAF_RS08145	COG0084	hydrolase, TatD family'
DESAF_RS08155	COG1216	Glycosyl transferase, family 2
DESAF_RS08165	COG0071	Belongs to the small heat shock protein (HSP20) family
DESAF_RS08170	COG2835	tetraacyldisaccharide 4'-kinase activity
DESAF_RS08175	COG0613	PHP domain protein
DESAF_RS08180	COG0826	peptidase U32
DESAF_RS08220	COG4191	Histidine kinase
DESAF_RS08225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DESAF_RS08235	COG2204	response regulator
DESAF_RS08245	COG1047	Peptidyl-prolyl cis-trans
DESAF_RS08255	COG0668	transmembrane transport
DESAF_RS08275	COG2205	protein histidine kinase activity
DESAF_RS08275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESAF_RS08285	COG0803	Belongs to the bacterial solute-binding protein 9 family
DESAF_RS08285	COG3443	Belongs to the bacterial solute-binding protein 9 family
DESAF_RS08290	COG0701	Predicted permease
DESAF_RS08310	COG1032	radical SAM domain protein
DESAF_RS08325	COG1136	(ABC) transporter
DESAF_RS08325	COG0577	efflux transmembrane transporter activity
DESAF_RS08340	COG2943	transferase activity, transferring hexosyl groups
DESAF_RS08350	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DESAF_RS08400	COG1309	transcriptional regulator
DESAF_RS08410	COG1053	succinate dehydrogenase
DESAF_RS08415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DESAF_RS08430	COG0280	phosphate acetyltransferase
DESAF_RS08430	COG0281	malic enzyme
DESAF_RS08435	COG0471	metal ion transport
DESAF_RS08445	COG4656	Part of a membrane complex involved in electron transport
DESAF_RS08450	COG4658	electron transport chain
DESAF_RS08460	COG4660	Part of a membrane complex involved in electron transport
DESAF_RS08465	COG4657	Part of a membrane complex involved in electron transport
DESAF_RS08475	COG1077	Cell shape determining protein MreB Mrl
DESAF_RS08505	COG1120	ATPase activity
DESAF_RS08510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DESAF_RS08545	COG1119	ATPase activity
DESAF_RS08550	COG5001	Diguanylate cyclase
DESAF_RS08550	COG3300	MHYT domain
DESAF_RS08555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DESAF_RS08565	COG2414	aldehyde ferredoxin oxidoreductase
DESAF_RS08575	COG1218	3'(2'),5'-bisphosphate nucleotidase
DESAF_RS08595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DESAF_RS08605	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DESAF_RS08610	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DESAF_RS08615	COG1309	transcriptional regulator
DESAF_RS08620	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DESAF_RS08650	COG0765	amino acid transport
DESAF_RS08670	COG0745	RESPONSE REGULATOR receiver
DESAF_RS08690	COG4181	ATPase activity
DESAF_RS08705	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DESAF_RS08715	COG3437	response regulator, receiver
DESAF_RS08715	COG3850	Histidine kinase
DESAF_RS08715	COG2205	protein histidine kinase activity
DESAF_RS08715	COG4999	Histidine kinase
DESAF_RS08730	COG2270	Major facilitator Superfamily
DESAF_RS08755	COG0436	Aminotransferase
DESAF_RS08775	COG1773	rubredoxin
DESAF_RS08805	COG0737	Belongs to the 5'-nucleotidase family
DESAF_RS08810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DESAF_RS08815	COG0142	geranyltranstransferase activity
DESAF_RS08830	COG2226	methyltransferase
DESAF_RS08860	COG1253	flavin adenine dinucleotide binding
DESAF_RS08865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESAF_RS08875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DESAF_RS08880	COG1522	sequence-specific DNA binding
DESAF_RS08885	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DESAF_RS08900	COG0840	transmembrane signaling receptor activity
DESAF_RS08910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DESAF_RS08915	COG1592	Rubrerythrin
DESAF_RS08945	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DESAF_RS08950	COG0725	ABC transporter, periplasmic molybdate-binding protein
DESAF_RS08955	COG4149	molybdate abc transporter
DESAF_RS08965	COG2205	protein histidine kinase activity
DESAF_RS08965	COG0784	Response regulator, receiver
DESAF_RS08970	COG2998	abc-type tungstate transport system, permease component
DESAF_RS08980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DESAF_RS08985	COG0746	molybdenum cofactor guanylyltransferase activity
DESAF_RS08990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DESAF_RS09030	COG0493	'glutamate synthase
DESAF_RS09035	COG0543	2 iron, 2 sulfur cluster binding
DESAF_RS09040	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DESAF_RS09055	COG3655	Transcriptional regulator
DESAF_RS09075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DESAF_RS09075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESAF_RS09090	COG1773	rubredoxin
DESAF_RS09100	COG0489	protein tyrosine kinase activity
DESAF_RS09135	COG3604	Transcriptional regulator
DESAF_RS09145	COG0489	protein tyrosine kinase activity
DESAF_RS09155	COG2204	response regulator
DESAF_RS09160	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DESAF_RS09165	COG1797	cobyrinic acid a,c-diamide synthase activity
DESAF_RS09170	COG2205	protein histidine kinase activity
DESAF_RS09170	COG0784	Response regulator, receiver
DESAF_RS09170	COG2198	Histidine kinase
DESAF_RS09175	COG0318	PFAM AMP-dependent synthetase and ligase
DESAF_RS09185	COG1157	protein secretion by the type III secretion system
DESAF_RS09195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DESAF_RS09200	COG1766	The M ring may be actively involved in energy transduction
DESAF_RS09205	COG1677	Flagellar hook-basal body complex protein FliE
DESAF_RS09215	COG1815	bacterial-type flagellum-dependent cell motility
DESAF_RS09255	COG1796	DNA polymerase
DESAF_RS09255	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DESAF_RS09260	COG0724	RNA recognition motif
DESAF_RS09270	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DESAF_RS09280	COG0138	bifunctional purine biosynthesis protein purh
DESAF_RS09290	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DESAF_RS09315	COG2048	Heterodisulfide reductase, subunit B
DESAF_RS09325	COG0446	pyridine nucleotide-disulphide oxidoreductase
DESAF_RS09355	COG2204	response regulator
DESAF_RS09360	COG0159	tryptophan synthase activity
DESAF_RS09365	COG0133	tryptophan synthase activity
DESAF_RS09370	COG0135	phosphoribosylanthranilate isomerase activity
DESAF_RS09375	COG0134	indole-3-glycerol-phosphate synthase activity
DESAF_RS09380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DESAF_RS09390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DESAF_RS09395	COG1605	Chorismate mutase
DESAF_RS09395	COG0287	Prephenate dehydrogenase
DESAF_RS09400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DESAF_RS09405	COG0077	Prephenate dehydratase
DESAF_RS09405	COG1605	Chorismate mutase
DESAF_RS09410	COG1465	3-dehydroquinate synthase
DESAF_RS09415	COG1830	Aldolase
DESAF_RS09420	COG0004	ammonium transporteR
DESAF_RS09425	COG0347	Belongs to the P(II) protein family
DESAF_RS09450	COG1335	isochorismatase
DESAF_RS09465	COG0840	transmembrane signaling receptor activity
DESAF_RS09475	COG0573	inorganic phosphate transmembrane transporter activity
DESAF_RS09500	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DESAF_RS09615	COG4386	tail sheath protein
DESAF_RS09690	COG1525	nuclease
DESAF_RS09800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DESAF_RS09810	COG1546	Belongs to the CinA family
DESAF_RS09810	COG1058	Belongs to the CinA family
DESAF_RS09815	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DESAF_RS09825	COG0589	response to stress
DESAF_RS09830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DESAF_RS09835	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DESAF_RS09850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESAF_RS09860	COG0612	Peptidase, M16
DESAF_RS09880	COG0778	Nitroreductase
DESAF_RS09880	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DESAF_RS09885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESAF_RS09895	COG1040	competence protein
DESAF_RS09900	COG1335	isochorismatase
DESAF_RS09910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DESAF_RS09915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DESAF_RS09920	COG2249	NAD(P)H dehydrogenase (quinone) activity
DESAF_RS09930	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DESAF_RS09940	COG0840	transmembrane signaling receptor activity
DESAF_RS09975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DESAF_RS09980	COG0573	inorganic phosphate transmembrane transporter activity
DESAF_RS09985	COG0573	inorganic phosphate transmembrane transporter activity
DESAF_RS09990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DESAF_RS10000	COG0513	Belongs to the DEAD box helicase family
DESAF_RS10035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESAF_RS10060	COG2204	response regulator
DESAF_RS10080	COG0745	RESPONSE REGULATOR receiver
DESAF_RS10085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESAF_RS10090	COG0577	efflux transmembrane transporter activity
DESAF_RS10090	COG1136	(ABC) transporter
DESAF_RS10095	COG1538	Outer membrane efflux protein
DESAF_RS10115	COG0438	transferase activity, transferring glycosyl groups
DESAF_RS10135	COG1366	Belongs to the anti-sigma-factor antagonist family
DESAF_RS10140	COG1366	Belongs to the anti-sigma-factor antagonist family
DESAF_RS10145	COG2172	sigma factor antagonist activity
DESAF_RS10155	COG4251	negative regulation of phosphorylation
DESAF_RS10160	COG0784	Response regulator, receiver
DESAF_RS10165	COG2198	Histidine kinase
DESAF_RS10165	COG0784	Response regulator, receiver
DESAF_RS10165	COG5002	protein histidine kinase activity
DESAF_RS10195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DESAF_RS10205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DESAF_RS10215	COG1366	Belongs to the anti-sigma-factor antagonist family
DESAF_RS10220	COG2770	Histidine kinase
DESAF_RS10220	COG2208	phosphoserine phosphatase activity
DESAF_RS10225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DESAF_RS10235	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DESAF_RS10270	COG3956	TIGRFAM MazG family protein
DESAF_RS10285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DESAF_RS10300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DESAF_RS10335	COG3852	Histidine kinase
DESAF_RS10340	COG4753	response regulator
DESAF_RS10340	COG2207	Transcriptional regulator
DESAF_RS10350	COG2204	response regulator
DESAF_RS10365	COG0693	protein deglycase activity
DESAF_RS10380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DESAF_RS10390	COG0670	Belongs to the BI1 family
DESAF_RS10395	COG1663	tetraacyldisaccharide 4'-kinase activity
DESAF_RS10400	COG0557	exoribonuclease II activity
DESAF_RS10455	COG1181	Belongs to the D-alanine--D-alanine ligase family
DESAF_RS10470	COG2204	response regulator
DESAF_RS10495	COG1494	fructose-1,6-bisphosphatase
DESAF_RS10500	COG0698	ribose 5-phosphate isomerase
DESAF_RS10525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DESAF_RS10535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DESAF_RS10540	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DESAF_RS10565	COG0697	spore germination
DESAF_RS10575	COG0739	heme binding
DESAF_RS10600	COG0321	lipoyl(octanoyl) transferase activity
DESAF_RS10605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DESAF_RS10615	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DESAF_RS10615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DESAF_RS10625	COG0284	orotidine-5'-phosphate decarboxylase activity
DESAF_RS10630	COG0194	GDP metabolic process
DESAF_RS10635	COG2052	Domain of unknown function (DUF370)
DESAF_RS10640	COG1561	YicC-like family, N-terminal region
DESAF_RS10645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESAF_RS10660	COG0482	sulfurtransferase activity
DESAF_RS10670	COG0154	amidase activity
DESAF_RS10675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DESAF_RS10685	COG0443	Heat shock 70 kDa protein
DESAF_RS10690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DESAF_RS10695	COG1420	regulation of RNA biosynthetic process
DESAF_RS10715	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DESAF_RS10745	COG3259	Nickel-dependent hydrogenase
DESAF_RS10750	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DESAF_RS10760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DESAF_RS10765	COG0105	UTP biosynthetic process
DESAF_RS10770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DESAF_RS10775	COG4120	Belongs to the binding-protein-dependent transport system permease family
DESAF_RS10785	COG2861	carbohydrate metabolic process
DESAF_RS10790	COG0793	Belongs to the peptidase S41A family
DESAF_RS10795	COG1388	LysM domain
DESAF_RS10795	COG0739	heme binding
DESAF_RS10805	COG2264	protein methyltransferase activity
DESAF_RS10815	COG1162	GTPase activity
DESAF_RS10820	COG0640	Transcriptional regulator
DESAF_RS10835	COG3118	belongs to the thioredoxin family
DESAF_RS10850	COG3118	belongs to the thioredoxin family
DESAF_RS10865	COG2226	methyltransferase
DESAF_RS10870	COG0640	Transcriptional regulator
DESAF_RS10875	COG0798	PFAM Bile acid sodium symporter
DESAF_RS10880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DESAF_RS10890	COG2204	response regulator
DESAF_RS10895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DESAF_RS10910	COG0730	response to heat
DESAF_RS10920	COG2183	response to ionizing radiation
DESAF_RS10935	COG1139	Iron-sulfur cluster binding protein
DESAF_RS10950	COG0857	belongs to the CobB CobQ family
DESAF_RS10950	COG0280	phosphate acetyltransferase
DESAF_RS10955	COG0247	lactate metabolic process
DESAF_RS10960	COG0277	FAD linked oxidase domain protein
DESAF_RS10965	COG1620	l-lactate permease
DESAF_RS10970	COG1620	l-lactate permease
DESAF_RS10980	COG2204	response regulator
DESAF_RS10995	COG0049	tRNA binding
DESAF_RS11000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DESAF_RS11010	COG0051	transcription antitermination factor activity, RNA binding
DESAF_RS11015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DESAF_RS11020	COG0088	Forms part of the polypeptide exit tunnel
DESAF_RS11025	COG0089	rRNA binding
DESAF_RS11030	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DESAF_RS11035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DESAF_RS11040	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DESAF_RS11045	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DESAF_RS11050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DESAF_RS11055	COG0255	Belongs to the universal ribosomal protein uL29 family
DESAF_RS11060	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DESAF_RS11065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DESAF_RS11075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DESAF_RS11080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DESAF_RS11085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DESAF_RS11090	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DESAF_RS11095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DESAF_RS11100	COG1841	ribosomal large subunit assembly
DESAF_RS11105	COG0200	Binds to the 23S rRNA
DESAF_RS11115	COG0024	Methionine aminopeptidase
DESAF_RS11120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DESAF_RS11125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DESAF_RS11130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DESAF_RS11135	COG0202	RNA polymerase activity
DESAF_RS11140	COG0203	ribosomal protein L17
DESAF_RS11145	COG0583	DNA-binding transcription factor activity
DESAF_RS11155	COG0436	Aminotransferase
DESAF_RS11185	COG2135	peptidase activity
DESAF_RS11320	COG0542	response to heat
DESAF_RS11325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DESAF_RS11340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DESAF_RS11345	COG1278	Cold shock
DESAF_RS11365	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DESAF_RS11370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DESAF_RS11375	COG1360	Flagellar Motor Protein
DESAF_RS11385	COG0439	Biotin carboxylase
DESAF_RS11390	COG0825	malonyl-CoA metabolic process
DESAF_RS11420	COG3852	Histidine kinase
DESAF_RS11425	COG5001	Diguanylate cyclase
DESAF_RS11425	COG3300	MHYT domain
DESAF_RS11480	COG1846	Transcriptional regulator
DESAF_RS11495	COG2815	serine threonine protein kinase
DESAF_RS11495	COG0515	serine threonine protein kinase
DESAF_RS11500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DESAF_RS11545	COG0519	Catalyzes the synthesis of GMP from XMP
DESAF_RS11545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DESAF_RS11555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DESAF_RS11560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DESAF_RS11565	COG3706	GGDEF domain
DESAF_RS11575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DESAF_RS11590	COG0840	transmembrane signaling receptor activity
DESAF_RS11615	COG2081	HI0933 family
DESAF_RS11630	COG2095	MarC family integral membrane protein
DESAF_RS11650	COG4608	Belongs to the ABC transporter superfamily
DESAF_RS11655	COG0444	Belongs to the ABC transporter superfamily
DESAF_RS11660	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DESAF_RS11670	COG0840	transmembrane signaling receptor activity
DESAF_RS11685	COG1028	Short-chain dehydrogenase reductase Sdr
DESAF_RS11705	COG4191	Histidine kinase
DESAF_RS11710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DESAF_RS11715	COG1254	Belongs to the acylphosphatase family
DESAF_RS11720	COG2003	Belongs to the UPF0758 family
DESAF_RS11735	COG0495	leucyl-tRNA aminoacylation
DESAF_RS11740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DESAF_RS11745	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DESAF_RS11750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DESAF_RS11750	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DESAF_RS11755	COG0307	riboflavin synthase, alpha
DESAF_RS11760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DESAF_RS11760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DESAF_RS11790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DESAF_RS11800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DESAF_RS11810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DESAF_RS11815	COG2197	response regulator
DESAF_RS11870	COG4191	Histidine kinase
DESAF_RS11875	COG3678	ATP-independent chaperone mediated protein folding
DESAF_RS11880	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DESAF_RS11885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DESAF_RS11895	COG0617	tRNA 3'-terminal CCA addition
DESAF_RS11905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DESAF_RS11910	COG1475	DNA binding
DESAF_RS11925	COG2313	pseudouridylate synthase activity
DESAF_RS11930	COG0765	amino acid transport
DESAF_RS11945	COG0765	amino acid transport
DESAF_RS11960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DESAF_RS11965	COG3481	metal-dependent phosphohydrolase, HD sub domain
DESAF_RS11970	COG1858	cytochrome C peroxidase
DESAF_RS11975	COG2132	Multicopper oxidase
DESAF_RS11980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DESAF_RS11985	COG0191	fructose-bisphosphate aldolase activity
DESAF_RS11995	COG3920	Histidine kinase
DESAF_RS12015	COG1490	D-aminoacyl-tRNA deacylase activity
DESAF_RS12035	COG0859	PFAM glycosyl transferase family 9
DESAF_RS12045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DESAF_RS12060	COG0571	ribonuclease III activity
DESAF_RS12065	COG0857	belongs to the CobB CobQ family
DESAF_RS12070	COG0328	RNA-DNA hybrid ribonuclease activity
DESAF_RS12090	COG0861	Integral membrane protein TerC family
DESAF_RS12120	COG3034	peptidoglycan biosynthetic process
DESAF_RS12125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DESAF_RS12130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DESAF_RS12140	COG1058	Belongs to the CinA family
DESAF_RS12140	COG1546	Belongs to the CinA family
DESAF_RS12150	COG0534	Mate efflux family protein
DESAF_RS12170	COG0791	NLP P60 protein
DESAF_RS12175	COG2951	lytic endotransglycosylase activity
DESAF_RS12200	COG0438	transferase activity, transferring glycosyl groups
DESAF_RS12205	COG0463	Glycosyl transferase, family 2
DESAF_RS12210	COG1691	(AIR) carboxylase
DESAF_RS12215	COG2204	response regulator
DESAF_RS12225	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DESAF_RS12255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DESAF_RS12270	COG0628	permease
DESAF_RS12275	COG1295	ribonuclease BN
DESAF_RS12275	COG1959	2 iron, 2 sulfur cluster binding
DESAF_RS12290	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DESAF_RS12290	COG0493	'glutamate synthase
DESAF_RS12295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DESAF_RS12305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DESAF_RS12320	COG0189	ligase activity
DESAF_RS12320	COG0569	domain protein
DESAF_RS12325	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DESAF_RS12335	COG4191	Histidine kinase
DESAF_RS12340	COG2204	response regulator
DESAF_RS12350	COG0745	RESPONSE REGULATOR receiver
DESAF_RS12355	COG3852	Histidine kinase
DESAF_RS12365	COG2204	response regulator
DESAF_RS12380	COG2204	response regulator
DESAF_RS12385	COG1177	transmembrane transport
DESAF_RS12390	COG1176	ABC-type spermidine putrescine transport system, permease component I
DESAF_RS12395	COG3842	ATPase activity
DESAF_RS12400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DESAF_RS12425	COG0215	cysteine-tRNA ligase activity
DESAF_RS12445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DESAF_RS12445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DESAF_RS12455	COG1028	Short-chain dehydrogenase reductase Sdr
DESAF_RS12475	COG0492	ferredoxin-NADP+ reductase activity
DESAF_RS12480	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DESAF_RS12495	COG0297	glycogen (starch) synthase activity
DESAF_RS12535	COG0616	signal peptide processing
DESAF_RS12540	COG0492	ferredoxin-NADP+ reductase activity
DESAF_RS12545	COG2208	phosphoserine phosphatase activity
DESAF_RS12550	COG2204	response regulator
DESAF_RS12580	COG0538	isocitrate dehydrogenase activity
DESAF_RS12585	COG2423	ornithine cyclodeaminase activity
DESAF_RS12590	COG1811	Na channel or pump
DESAF_RS12660	COG0840	transmembrane signaling receptor activity
DESAF_RS12745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DESAF_RS12770	COG0835	chemotaxis
DESAF_RS12785	COG0840	transmembrane signaling receptor activity
DESAF_RS12790	COG2217	Heavy metal translocating P-type atpase
DESAF_RS12805	COG2197	response regulator
DESAF_RS12830	COG2080	2 iron, 2 sulfur cluster binding
DESAF_RS12835	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DESAF_RS12840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DESAF_RS12845	COG0454	-acetyltransferase
DESAF_RS12865	COG2233	PERMEase
DESAF_RS12870	COG3119	arylsulfatase activity
DESAF_RS12875	COG0641	radical SAM
DESAF_RS12900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DESAF_RS12930	COG1830	Aldolase
DESAF_RS12945	COG0517	IMP dehydrogenase activity
DESAF_RS12945	COG4175	Glycine betaine
DESAF_RS12970	COG2204	response regulator
DESAF_RS12980	COG5002	protein histidine kinase activity
DESAF_RS12980	COG0784	Response regulator, receiver
DESAF_RS12980	COG2198	Histidine kinase
DESAF_RS13005	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DESAF_RS13010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DESAF_RS13015	COG2226	methyltransferase
DESAF_RS13045	COG1215	transferase activity, transferring glycosyl groups
DESAF_RS13100	COG1136	(ABC) transporter
DESAF_RS13105	COG0842	Transport permease protein
DESAF_RS13110	COG1131	(ABC) transporter
DESAF_RS13170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DESAF_RS13180	COG1597	lipid kinase activity
DESAF_RS13185	COG3189	MarR family transcriptional regulator
DESAF_RS13190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DESAF_RS13195	COG1522	sequence-specific DNA binding
DESAF_RS13200	COG0535	radical SAM domain protein
DESAF_RS13205	COG0113	porphobilinogen synthase activity
DESAF_RS13220	COG0535	radical SAM domain protein
DESAF_RS13240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DESAF_RS13250	COG0438	transferase activity, transferring glycosyl groups
DESAF_RS13260	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DESAF_RS13265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DESAF_RS13270	COG1214	PFAM Peptidase M22, glycoprotease
DESAF_RS13275	COG0750	zinc metalloprotease
DESAF_RS13280	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DESAF_RS13285	COG4589	Belongs to the CDS family
DESAF_RS13290	COG1773	rubredoxin
DESAF_RS13315	COG0436	Aminotransferase
DESAF_RS13355	COG0629	single-stranded DNA binding
DESAF_RS13380	COG0022	dehydrogenase e1 component
DESAF_RS13385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DESAF_RS13390	COG0739	heme binding
DESAF_RS13395	COG0037	tRNA processing
DESAF_RS13405	COG1758	RNA polymerase activity
DESAF_RS13415	COG0315	cyclic pyranopterin monophosphate synthase activity
DESAF_RS13430	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DESAF_RS13445	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DESAF_RS13450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DESAF_RS13455	COG0612	Peptidase, M16
DESAF_RS13460	COG4783	chaperone-mediated protein folding
DESAF_RS13465	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DESAF_RS13480	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DESAF_RS13485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DESAF_RS13500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESAF_RS13515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DESAF_RS13525	COG0776	regulation of translation
DESAF_RS13545	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DESAF_RS13550	COG4535	Mg2 and Co2 transporter CorC
DESAF_RS13555	COG0445	tRNA wobble uridine modification
DESAF_RS13560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DESAF_RS13570	COG0402	S-adenosylhomocysteine deaminase activity
DESAF_RS13580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DESAF_RS13595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESAF_RS13600	COG0527	aspartate kinase activity
DESAF_RS13605	COG0802	atpase or kinase
DESAF_RS13610	COG0617	tRNA 3'-terminal CCA addition
DESAF_RS13610	COG0517	IMP dehydrogenase activity
DESAF_RS13610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DESAF_RS13615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DESAF_RS13615	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DESAF_RS13620	COG0736	holo-[acyl-carrier-protein] synthase activity
DESAF_RS13625	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DESAF_RS13640	COG0835	chemotaxis
DESAF_RS13655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DESAF_RS13665	COG1381	Involved in DNA repair and RecF pathway recombination
DESAF_RS13675	COG0751	glycine-tRNA ligase activity
DESAF_RS13680	COG0268	Binds directly to 16S ribosomal RNA
DESAF_RS13700	COG0018	arginyl-trna synthetase
DESAF_RS13705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DESAF_RS13720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DESAF_RS13730	COG5000	phosphorelay sensor kinase activity
DESAF_RS13735	COG1090	epimerase
DESAF_RS13745	COG2204	response regulator
DESAF_RS13755	COG0708	Exodeoxyribonuclease III
DESAF_RS13765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DESAF_RS13770	COG1496	oxidoreductase activity
DESAF_RS13785	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DESAF_RS13795	COG1136	(ABC) transporter
DESAF_RS13800	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DESAF_RS13810	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DESAF_RS13815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DESAF_RS13820	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DESAF_RS13825	COG3494	Protein of unknown function (DUF1009)
DESAF_RS13830	COG1774	PSP1 C-terminal conserved region
DESAF_RS13835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DESAF_RS13835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DESAF_RS13850	COG0563	adenylate kinase activity
DESAF_RS13855	COG0037	tRNA processing
DESAF_RS13885	COG1132	(ABC) transporter
DESAF_RS13905	COG2084	Dehydrogenase
DESAF_RS13965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DESAF_RS13970	COG0351	phosphomethylpyrimidine kinase
DESAF_RS13970	COG0352	thiamine-phosphate diphosphorylase activity
DESAF_RS13980	COG0840	transmembrane signaling receptor activity
DESAF_RS13985	COG0544	peptidyl-prolyl cis-trans isomerase activity
DESAF_RS13990	COG0740	serine-type endopeptidase activity
DESAF_RS14000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DESAF_RS14010	COG3012	SEC-C Motif Domain Protein
DESAF_RS14030	COG0137	argininosuccinate synthase activity
DESAF_RS14035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DESAF_RS14040	COG0165	Argininosuccinate lyase
DESAF_RS14050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DESAF_RS14055	COG0456	acetyltransferase
DESAF_RS14070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DESAF_RS14150	COG0784	Response regulator, receiver
DESAF_RS14150	COG2198	Histidine kinase
DESAF_RS14150	COG5002	protein histidine kinase activity
DESAF_RS14160	COG0824	Thioesterase
DESAF_RS14165	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DESAF_RS14195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DESAF_RS14240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DESAF_RS14245	COG0835	chemotaxis
DESAF_RS14265	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DESAF_RS14270	COG1704	LemA family
DESAF_RS14280	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DESAF_RS14300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DESAF_RS14305	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DESAF_RS14315	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DESAF_RS14325	COG1160	GTP binding
DESAF_RS14365	COG1830	Aldolase
DESAF_RS14435	COG2048	Heterodisulfide reductase, subunit B
DESAF_RS14445	COG1454	alcohol dehydrogenase
DESAF_RS14450	COG2204	response regulator
DESAF_RS14455	COG3852	Histidine kinase
DESAF_RS14465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DESAF_RS14470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DESAF_RS14475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DESAF_RS14495	COG1993	acr, cog1993
DESAF_RS14500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DESAF_RS14510	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DESAF_RS14515	COG0542	response to heat
DESAF_RS14520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DESAF_RS14535	COG0556	nucleotide-excision repair
DESAF_RS14540	COG0490	domain, Protein
DESAF_RS14545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DESAF_RS14555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DESAF_RS14560	COG0318	PFAM AMP-dependent synthetase and ligase
DESAF_RS14590	COG4232	protein-disulfide reductase activity
DESAF_RS14610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DESAF_RS14620	COG2239	Acts as a magnesium transporter
DESAF_RS14650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DESAF_RS14655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DESAF_RS14665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DESAF_RS14670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DESAF_RS14680	COG0310	cobalt ion transport
DESAF_RS14690	COG0438	transferase activity, transferring glycosyl groups
DESAF_RS14700	COG4662	Binding-protein-dependent transport system inner membrane component
DESAF_RS14710	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DESAF_RS14720	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DESAF_RS14725	COG2169	Transcriptional regulator
DESAF_RS14725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DESAF_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
DESAF_RS14750	COG0574	Belongs to the PEP-utilizing enzyme family
DESAF_RS14750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DESAF_RS14765	COG4641	Protein conserved in bacteria
DESAF_RS14775	COG1648	precorrin-2 dehydrogenase activity
DESAF_RS14775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DESAF_RS14780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DESAF_RS14785	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DESAF_RS14795	COG1584	GPR1 FUN34 yaaH family protein
DESAF_RS14805	COG2801	Transposase and inactivated derivatives
DESAF_RS14825	COG0175	sulfate reduction
DESAF_RS14830	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DESAF_RS14840	COG1570	exodeoxyribonuclease VII activity
DESAF_RS14845	COG0739	heme binding
DESAF_RS14850	COG1722	exodeoxyribonuclease VII activity
DESAF_RS14860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DESAF_RS14865	COG2770	Histidine kinase
DESAF_RS14865	COG3437	response regulator, receiver
DESAF_RS14870	COG0529	Catalyzes the synthesis of activated sulfate
DESAF_RS14870	COG2046	Belongs to the sulfate adenylyltransferase family
DESAF_RS14880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DESAF_RS14885	COG0366	Alpha amylase catalytic
DESAF_RS14890	COG0366	Alpha amylase catalytic
DESAF_RS14895	COG1741	Belongs to the pirin family
DESAF_RS14920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DESAF_RS14930	COG1174	glycine betaine transport
DESAF_RS14940	COG1174	glycine betaine transport
DESAF_RS14945	COG1732	Glycine betaine
DESAF_RS14950	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DESAF_RS14955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DESAF_RS14965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DESAF_RS14975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DESAF_RS14980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DESAF_RS14995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DESAF_RS15015	COG0028	Belongs to the TPP enzyme family
DESAF_RS15020	COG0440	acetolactate synthase activity
DESAF_RS15025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DESAF_RS15030	COG2814	Major facilitator Superfamily
DESAF_RS15045	COG1968	undecaprenyl-diphosphatase activity
DESAF_RS15065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DESAF_RS15075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DESAF_RS15080	COG1674	ftsk spoiiie
DESAF_RS15090	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DESAF_RS15095	COG1187	pseudouridine synthase activity
DESAF_RS15105	COG1132	(ABC) transporter
DESAF_RS15115	COG1560	Kdo2-lipid A biosynthetic process
DESAF_RS15155	COG0163	prenyltransferase activity
DESAF_RS15175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DESAF_RS15180	COG0436	Aminotransferase
DESAF_RS15185	COG4974	Belongs to the 'phage' integrase family
DESAF_RS15190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DESAF_RS15190	COG0617	tRNA 3'-terminal CCA addition
DESAF_RS15190	COG3620	sequence-specific DNA binding
DESAF_RS15210	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DESAF_RS15215	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DESAF_RS15225	COG0019	diaminopimelate decarboxylase activity
DESAF_RS15230	COG2201	protein-glutamate methylesterase activity
DESAF_RS15235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DESAF_RS15240	COG2198	Histidine kinase
DESAF_RS15240	COG0643	Histidine kinase
DESAF_RS15245	COG0745	RESPONSE REGULATOR receiver
DESAF_RS15275	COG0438	transferase activity, transferring glycosyl groups
DESAF_RS15280	COG0438	transferase activity, transferring glycosyl groups
DESAF_RS15290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DESAF_RS15300	COG0577	efflux transmembrane transporter activity
DESAF_RS15305	COG1136	(ABC) transporter
DESAF_RS15335	COG2081	HI0933 family
DESAF_RS15340	COG0069	glutamate synthase activity
DESAF_RS15340	COG0070	glutamate synthase
DESAF_RS15340	COG0067	glutamate synthase
DESAF_RS15360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DESAF_RS15365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DESAF_RS15370	COG1862	Preprotein translocase
DESAF_RS15380	COG0067	glutamate synthase
DESAF_RS15385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DESAF_RS15385	COG2146	nitrite reductase [NAD(P)H] activity
DESAF_RS15390	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DESAF_RS15405	COG0017	Asparaginyl-tRNA synthetase
DESAF_RS15410	COG0788	formyltetrahydrofolate deformylase activity
DESAF_RS15415	COG0552	protein localization to endoplasmic reticulum
DESAF_RS15435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DESAF_RS15440	COG0149	triose-phosphate isomerase activity
DESAF_RS15445	COG0126	phosphoglycerate kinase activity
DESAF_RS15450	COG0456	acetyltransferase
DESAF_RS15455	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DESAF_RS15460	COG0483	inositol monophosphate 1-phosphatase activity
DESAF_RS15480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DESAF_RS15490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DESAF_RS15525	COG0358	DNA primase activity
DESAF_RS15530	COG1193	negative regulation of DNA recombination
DESAF_RS15540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DESAF_RS15545	COG0776	regulation of translation
DESAF_RS15550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DESAF_RS15555	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DESAF_RS15565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DESAF_RS15575	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DESAF_RS15580	COG0492	ferredoxin-NADP+ reductase activity
DESAF_RS15590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DESAF_RS15620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DESAF_RS15625	COG0489	protein tyrosine kinase activity
DESAF_RS15630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DESAF_RS15635	COG0517	IMP dehydrogenase activity
DESAF_RS15635	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DESAF_RS15635	COG0617	tRNA 3'-terminal CCA addition
DESAF_RS15650	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DESAF_RS15655	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DESAF_RS15660	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DESAF_RS15680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DESAF_RS15680	COG0574	Belongs to the PEP-utilizing enzyme family
DESAF_RS15690	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DESAF_RS15690	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DESAF_RS15695	COG0617	tRNA 3'-terminal CCA addition
DESAF_RS15700	COG0402	S-adenosylhomocysteine deaminase activity
DESAF_RS15715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DESAF_RS15720	COG0742	ribosomal rna small subunit methyltransferase
DESAF_RS15725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DESAF_RS15730	COG0322	excinuclease ABC activity
DESAF_RS15745	COG4974	Belongs to the 'phage' integrase family
DESAF_RS15765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DESAF_RS15765	COG0758	DNA mediated transformation
DESAF_RS15785	COG0643	Histidine kinase
DESAF_RS15785	COG2198	Histidine kinase
DESAF_RS15790	COG0745	RESPONSE REGULATOR receiver
DESAF_RS15795	COG0835	chemotaxis
DESAF_RS15800	COG1192	Involved in chromosome partitioning
DESAF_RS15810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DESAF_RS15820	COG2201	protein-glutamate methylesterase activity
DESAF_RS15825	COG0513	Belongs to the DEAD box helicase family
DESAF_RS15830	COG1227	inorganic diphosphatase activity
DESAF_RS15840	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DESAF_RS15855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DESAF_RS15885	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DESAF_RS15895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DESAF_RS15895	COG0047	phosphoribosylformylglycinamidine synthase activity
DESAF_RS15935	COG2204	response regulator
DESAF_RS15945	COG5002	protein histidine kinase activity
DESAF_RS15950	COG2204	response regulator
DESAF_RS15955	COG0569	domain protein
DESAF_RS15960	COG0569	domain protein
DESAF_RS15965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DESAF_RS15970	COG0628	permease
DESAF_RS15980	COG0564	pseudouridine synthase activity
DESAF_RS15990	COG1238	metal cluster binding
DESAF_RS15995	COG0697	spore germination
DESAF_RS16000	COG1074	ATP-dependent DNA helicase activity
DESAF_RS16015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DESAF_RS16020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DESAF_RS16030	COG0360	Binds together with S18 to 16S ribosomal RNA
DESAF_RS16035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DESAF_RS16040	COG0359	binds to the 23S rRNA
DESAF_RS16045	COG0305	Participates in initiation and elongation during chromosome replication
DESAF_RS16060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DESAF_RS16065	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DESAF_RS16085	COG1830	Aldolase
DESAF_RS16090	COG0428	transporter
DESAF_RS16095	COG3237	CsbD-like
DESAF_RS16120	COG0719	Fe-S assembly protein
DESAF_RS16125	COG0396	ATPase activity
DESAF_RS16135	COG0564	pseudouridine synthase activity
DESAF_RS16140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DESAF_RS16150	COG1611	Belongs to the LOG family
DESAF_RS16160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DESAF_RS16170	COG0131	Imidazoleglycerol-phosphate dehydratase
DESAF_RS16175	COG0805	protein transport
DESAF_RS16180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DESAF_RS16190	COG0517	IMP dehydrogenase activity
DESAF_RS16190	COG0516	GMP reductase activity
DESAF_RS16220	COG0683	leucine binding
DESAF_RS16240	COG4555	ABC transporter
DESAF_RS16245	COG1138	Cytochrome C-type biogenesis protein
DESAF_RS16255	COG1253	flavin adenine dinucleotide binding
DESAF_RS16285	COG0473	3-isopropylmalate dehydrogenase activity
DESAF_RS16295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DESAF_RS16300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESAF_RS16305	COG1183	phosphatidylcholine synthase activity
DESAF_RS16310	COG0688	phosphatidylethanolamine metabolic process
DESAF_RS16320	COG3852	Histidine kinase
DESAF_RS16330	COG0656	L-ascorbic acid biosynthetic process
DESAF_RS16335	COG4822	anaerobic cobalamin biosynthetic process
DESAF_RS16340	COG0667	Aldo Keto reductase
DESAF_RS16345	COG0348	domain, Protein
DESAF_RS16350	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DESAF_RS16375	COG0310	cobalt ion transport
DESAF_RS16385	COG1122	ATPase activity
DESAF_RS16390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DESAF_RS16395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DESAF_RS16400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DESAF_RS16410	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DESAF_RS16415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DESAF_RS16420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESAF_RS16430	COG1584	GPR1 FUN34 yaaH family protein
DESAF_RS16445	COG4658	electron transport chain
DESAF_RS16455	COG4660	Part of a membrane complex involved in electron transport
DESAF_RS16460	COG4657	Part of a membrane complex involved in electron transport
DESAF_RS16470	COG1477	protein flavinylation
DESAF_RS16485	COG1122	ATPase activity
DESAF_RS16495	COG0375	protein maturation
DESAF_RS16525	COG0840	transmembrane signaling receptor activity
DESAF_RS16535	COG0489	protein tyrosine kinase activity
DESAF_RS16545	COG0840	transmembrane signaling receptor activity
DESAF_RS16555	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DESAF_RS16560	COG0799	negative regulation of ribosome biogenesis
DESAF_RS16565	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DESAF_RS16580	COG0784	Response regulator, receiver
DESAF_RS16580	COG5002	protein histidine kinase activity
DESAF_RS16585	COG0352	thiamine-phosphate diphosphorylase activity
DESAF_RS16595	COG3028	Belongs to the UPF0307 family
DESAF_RS16630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DESAF_RS16640	COG0028	Belongs to the TPP enzyme family
DESAF_RS16695	COG0432	Pfam Uncharacterised protein family UPF0047
DESAF_RS16700	COG3162	membrane
DESAF_RS16725	COG4191	Histidine kinase
DESAF_RS16735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESAF_RS16735	COG2205	protein histidine kinase activity
DESAF_RS16745	COG2204	response regulator
DESAF_RS16750	COG3852	Histidine kinase
DESAF_RS16780	COG2095	MarC family integral membrane protein
DESAF_RS16800	COG3239	Fatty acid desaturase
DESAF_RS16810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DESAF_RS16835	COG0835	chemotaxis
DESAF_RS16840	COG4399	Belongs to the UPF0754 family
DESAF_RS16860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESAF_RS16865	COG0765	amino acid transport
DESAF_RS16870	COG0252	asparaginase activity
DESAF_RS16890	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DESAF_RS16895	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DESAF_RS16910	COG1760	l-serine dehydratase
DESAF_RS16935	COG1433	Dinitrogenase iron-molybdenum cofactor
DESAF_RS16935	COG0535	radical SAM domain protein
DESAF_RS16950	COG0037	tRNA processing
DESAF_RS16965	COG2204	response regulator
DESAF_RS16970	COG1994	Peptidase M50
DESAF_RS16975	COG0180	Tryptophanyl-tRNA synthetase
DESAF_RS17005	COG0110	maltose O-acetyltransferase activity
DESAF_RS17010	COG0110	maltose O-acetyltransferase activity
DESAF_RS17040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESAF_RS17045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DESAF_RS17055	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DESAF_RS17060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DESAF_RS17065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DESAF_RS17075	COG0772	Belongs to the SEDS family
DESAF_RS17080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DESAF_RS17085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DESAF_RS17090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DESAF_RS17095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DESAF_RS17140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DESAF_RS17160	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DESAF_RS17270	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DESAF_RS17285	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DESAF_RS17290	COG1715	Restriction endonuclease
DESAF_RS17295	COG4804	nuclease activity
DESAF_RS17300	COG1715	Restriction endonuclease
DESAF_RS17340	COG1752	Esterase of the alpha-beta hydrolase superfamily
DESAF_RS17355	COG1280	lysine exporter protein (LysE YggA)
DESAF_RS17370	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DESAF_RS17380	COG1309	transcriptional regulator
DESAF_RS17420	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DESAF_RS17430	COG0784	Response regulator, receiver
DESAF_RS17450	COG2337	Toxic component of a toxin-antitoxin (TA) module
DESAF_RS17655	COG3290	protein histidine kinase activity
DESAF_RS17655	COG0840	transmembrane signaling receptor activity
DESAF_RS17660	COG1525	nuclease
DESAF_RS17670	COG3800	Transcriptional regulator
DESAF_RS17670	COG1396	sequence-specific DNA binding
DESAF_RS17770	COG1595	DNA-templated transcription, initiation
DESAF_RS17780	COG0243	molybdopterin cofactor binding
DESAF_RS17785	COG1140	nitrate reductase beta subunit
DESAF_RS17905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESAF_RS17950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESAF_RS17950	COG2205	protein histidine kinase activity
DESAF_RS17980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DESAF_RS17990	COG3920	Histidine kinase
DESAF_RS17995	COG1217	gtp-binding protein TYPA
DESAF_RS18000	COG2814	Major facilitator Superfamily
DESAF_RS18005	COG0542	response to heat
DESAF_RS18010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DESAF_RS18015	COG1993	acr, cog1993
DESAF_RS18020	COG0148	phosphopyruvate hydratase activity
DESAF_RS18035	COG2133	pyrroloquinoline quinone binding
DESAF_RS18045	COG1881	PFAM PEBP family protein
DESAF_RS18065	COG1966	Carbon starvation protein
DESAF_RS18070	COG3275	phosphorelay sensor kinase activity
DESAF_RS18075	COG3279	Response regulator of the LytR AlgR family
DESAF_RS18080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DESAF_RS18085	COG0840	transmembrane signaling receptor activity
DESAF_RS18090	COG0835	chemotaxis
DESAF_RS18105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DESAF_RS18125	COG1309	transcriptional regulator
DESAF_RS18130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESAF_RS18145	COG0840	transmembrane signaling receptor activity
DESAF_RS18150	COG0697	spore germination
DESAF_RS18175	COG1320	monovalent cation:proton antiporter activity
DESAF_RS18190	COG1006	Multisubunit Na H antiporter MnhC subunit
DESAF_RS18195	COG0651	ATP synthesis coupled electron transport
DESAF_RS18200	COG0651	ATP synthesis coupled electron transport
DESAF_RS18210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DESAF_RS18210	COG2111	Na H antiporter
DESAF_RS18220	COG0513	Belongs to the DEAD box helicase family
DESAF_RS18245	COG1733	regulation of RNA biosynthetic process
DESAF_RS18280	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DESAF_RS18305	COG0277	FAD linked oxidase domain protein
DESAF_RS18345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DESAF_RS18350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DESAF_RS18365	COG0535	radical SAM domain protein
DESAF_RS18390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DESAF_RS18400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DESAF_RS18420	COG1032	radical SAM domain protein
DESAF_RS18425	COG0463	Glycosyl transferase, family 2
DESAF_RS18435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DESAF_RS18440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DESAF_RS18475	COG0729	surface antigen
DESAF_RS18490	COG1366	Belongs to the anti-sigma-factor antagonist family
DESAF_RS18510	COG1132	(ABC) transporter
DESAF_RS18510	COG1132	(ABC) transporter
DESAF_RS18515	COG5557	Pfam Polysulphide reductase, NrfD
DESAF_RS18520	COG0437	4 iron, 4 sulfur cluster binding
DESAF_RS18525	COG0243	molybdopterin cofactor binding
DESAF_RS18580	COG0367	asparagine synthase
DESAF_RS18595	COG1013	pyruvate-flavodoxin oxidoreductase activity
DESAF_RS18600	COG0674	pyruvate-flavodoxin oxidoreductase activity
DESAF_RS18600	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DESAF_RS18610	COG1126	abc transporter atp-binding protein
DESAF_RS18615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESAF_RS18620	COG0765	amino acid transport
DESAF_RS18625	COG0765	amino acid transport
DESAF_RS18630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DESAF_RS18665	COG1846	Transcriptional regulator
DESAF_RS18705	COG0739	heme binding
DESAF_RS18710	COG1706	bacterial-type flagellum-dependent cell motility
DESAF_RS18715	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DESAF_RS18720	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
DESAF_RS18740	COG0779	Required for maturation of 30S ribosomal subunits
DESAF_RS18745	COG0195	Participates in both transcription termination and antitermination
DESAF_RS18750	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DESAF_RS18750	COG3266	domain, Protein
DESAF_RS18750	COG3266	domain, Protein
DESAF_RS18750	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DESAF_RS18760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DESAF_RS18770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DESAF_RS18775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DESAF_RS18780	COG1185	polyribonucleotide nucleotidyltransferase activity
DESAF_RS18785	COG2321	neutral zinc metallopeptidase
DESAF_RS18795	COG1355	regulation of microtubule-based process
DESAF_RS18815	COG1469	GTP cyclohydrolase I activity
DESAF_RS18825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DESAF_RS18835	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DESAF_RS18840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DESAF_RS18845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DESAF_RS18850	COG0840	transmembrane signaling receptor activity
DESAF_RS18865	COG1331	Highly conserved protein containing a thioredoxin domain
DESAF_RS18880	COG0577	efflux transmembrane transporter activity
DESAF_RS18890	COG1136	(ABC) transporter
DESAF_RS18895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESAF_RS18910	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DESAF_RS18920	COG0343	queuine tRNA-ribosyltransferase activity
DESAF_RS18925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DESAF_RS18940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DESAF_RS18965	COG0529	Catalyzes the synthesis of activated sulfate
DESAF_RS18970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESAF_RS18985	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DESAF_RS18990	COG0811	peptide transport
DESAF_RS19015	COG2885	chlorophyll binding
DESAF_RS19020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DESAF_RS19030	COG0424	maF-like protein
DESAF_RS19035	COG2885	chlorophyll binding
DESAF_RS19040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DESAF_RS19045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DESAF_RS19050	COG1480	7TM receptor with intracellular HD hydrolase
DESAF_RS19055	COG1702	phosphate starvation-inducible protein PhoH
DESAF_RS19100	COG2920	part of a sulfur-relay system
DESAF_RS19170	COG2369	cell adhesion
DESAF_RS19280	COG1515	deoxyribonuclease V activity
DESAF_RS19285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DESAF_RS19330	COG5002	protein histidine kinase activity
DESAF_RS19330	COG2198	Histidine kinase
DESAF_RS19330	COG0784	Response regulator, receiver
DESAF_RS19360	COG2863	cytochrome
DESAF_RS19435	COG2205	protein histidine kinase activity
DESAF_RS19435	COG3850	Histidine kinase
DESAF_RS19435	COG3437	response regulator, receiver
DESAF_RS19435	COG4999	Histidine kinase
DESAF_RS19445	COG0438	transferase activity, transferring glycosyl groups
DESAF_RS19460	COG3437	response regulator, receiver
DESAF_RS19505	COG3617	BRO family, N-terminal domain
DESAF_RS19550	COG0791	NLP P60 protein
DESAF_RS19635	COG1215	transferase activity, transferring glycosyl groups
DESAF_RS19665	COG0463	Glycosyl transferase, family 2
DESAF_RS19725	COG1215	transferase activity, transferring glycosyl groups
DESAF_RS19735	COG2226	methyltransferase
DESAF_RS19755	COG1280	lysine exporter protein (LysE YggA)
DESAF_RS19775	COG0594	ribonuclease P activity
DESAF_RS19835	COG4384	Bacteriophage Mu Gp45 protein
DESAF_RS19960	COG5487	UPF0391 membrane protein
DESAF_RS19985	COG0582	viral genome integration into host DNA
DESAF_RS19990	COG1872	DUF167
DESAF_RS20065	COG4251	negative regulation of phosphorylation