locus-tag	class	description
DESTI_RS00030	COG0187	DNA topoisomerase II activity
DESTI_RS00045	COG0489	protein tyrosine kinase activity
DESTI_RS00055	COG2048	Heterodisulfide reductase, subunit B
DESTI_RS00075	COG1013	pyruvate-flavodoxin oxidoreductase activity
DESTI_RS00080	COG0674	pyruvate-flavodoxin oxidoreductase activity
DESTI_RS00080	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DESTI_RS00120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DESTI_RS00170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DESTI_RS00195	COG0835	chemotaxis
DESTI_RS00205	COG0835	chemotaxis
DESTI_RS00215	COG2201	protein-glutamate methylesterase activity
DESTI_RS00230	COG1100	Small GTP-binding protein
DESTI_RS00235	COG3852	Histidine kinase
DESTI_RS00250	COG0688	phosphatidylethanolamine metabolic process
DESTI_RS00255	COG0440	acetolactate synthase activity
DESTI_RS00260	COG0028	Belongs to the TPP enzyme family
DESTI_RS00280	COG0149	triose-phosphate isomerase activity
DESTI_RS00285	COG0126	phosphoglycerate kinase activity
DESTI_RS00300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DESTI_RS00310	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS00315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DESTI_RS00350	COG4662	Binding-protein-dependent transport system inner membrane component
DESTI_RS00375	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DESTI_RS00385	COG0793	Belongs to the peptidase S41A family
DESTI_RS00400	COG2815	serine threonine protein kinase
DESTI_RS00400	COG0515	serine threonine protein kinase
DESTI_RS00430	COG0823	Involved in the tonB-independent uptake of proteins
DESTI_RS00445	COG0811	peptide transport
DESTI_RS00475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DESTI_RS00480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESTI_RS00485	COG1063	alcohol dehydrogenase
DESTI_RS00490	COG1187	pseudouridine synthase activity
DESTI_RS00500	COG1242	4 iron, 4 sulfur cluster binding
DESTI_RS00505	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DESTI_RS00515	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DESTI_RS00535	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DESTI_RS00565	COG0277	FAD linked oxidase domain protein
DESTI_RS00600	COG0840	transmembrane signaling receptor activity
DESTI_RS00605	COG3604	Transcriptional regulator
DESTI_RS00615	COG2373	Large extracellular alpha-helical protein
DESTI_RS00635	COG1078	dGTPase activity
DESTI_RS00665	COG0741	lytic transglycosylase activity
DESTI_RS00680	COG1793	dna ligase
DESTI_RS00680	COG3285	dna ligase
DESTI_RS00690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DESTI_RS00700	COG3118	belongs to the thioredoxin family
DESTI_RS00745	COG3958	Transketolase
DESTI_RS00750	COG3959	Transketolase, thiamine diphosphate binding domain
DESTI_RS00760	COG0529	Catalyzes the synthesis of activated sulfate
DESTI_RS00775	COG1674	ftsk spoiiie
DESTI_RS00790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DESTI_RS00800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DESTI_RS00830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DESTI_RS00850	COG1233	COG1233 Phytoene dehydrogenase and related
DESTI_RS00885	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DESTI_RS00890	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DESTI_RS00895	COG0101	tRNA pseudouridine synthase activity
DESTI_RS00930	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DESTI_RS00950	COG0183	Belongs to the thiolase family
DESTI_RS00975	COG1116	anion transmembrane transporter activity
DESTI_RS00975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DESTI_RS00980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DESTI_RS00985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DESTI_RS00995	COG3852	Histidine kinase
DESTI_RS01015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DESTI_RS01020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DESTI_RS01035	COG0784	Response regulator, receiver
DESTI_RS01050	COG2267	carboxylic ester hydrolase activity
DESTI_RS01085	COG1937	Protein conserved in bacteria
DESTI_RS01100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DESTI_RS01110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DESTI_RS01115	COG0740	serine-type endopeptidase activity
DESTI_RS01125	COG0463	Glycosyl transferase, family 2
DESTI_RS01150	COG0646	methionine synthase
DESTI_RS01150	COG1410	methionine synthase
DESTI_RS01180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESTI_RS01200	COG0095	Lipoate-protein ligase
DESTI_RS01205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DESTI_RS01220	COG0589	response to stress
DESTI_RS01225	COG0084	hydrolase, TatD family'
DESTI_RS01265	COG3852	Histidine kinase
DESTI_RS01320	COG0583	DNA-binding transcription factor activity
DESTI_RS01345	COG0544	peptidyl-prolyl cis-trans isomerase activity
DESTI_RS01350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DESTI_RS01365	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DESTI_RS01375	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS01405	COG5002	protein histidine kinase activity
DESTI_RS01420	COG0784	Response regulator, receiver
DESTI_RS01530	COG1100	Small GTP-binding protein
DESTI_RS01540	COG0515	serine threonine protein kinase
DESTI_RS01560	COG2894	cell division
DESTI_RS01600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DESTI_RS01610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DESTI_RS01630	COG1872	DUF167
DESTI_RS01635	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DESTI_RS01640	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DESTI_RS01645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESTI_RS01645	COG2205	protein histidine kinase activity
DESTI_RS01665	COG1846	Transcriptional regulator
DESTI_RS01670	COG0629	single-stranded DNA binding
DESTI_RS01680	COG1045	serine acetyltransferase
DESTI_RS01685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DESTI_RS01720	COG3259	Nickel-dependent hydrogenase
DESTI_RS01730	COG3383	formate dehydrogenase (NAD+) activity
DESTI_RS01750	COG2202	Pas domain
DESTI_RS01750	COG2205	protein histidine kinase activity
DESTI_RS01765	COG2204	response regulator
DESTI_RS01770	COG4191	Histidine kinase
DESTI_RS01775	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS01790	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DESTI_RS01810	COG0346	lactoylglutathione lyase activity
DESTI_RS01820	COG0424	maF-like protein
DESTI_RS01825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DESTI_RS01845	COG0228	four-way junction DNA binding
DESTI_RS01850	COG1837	Belongs to the UPF0109 family
DESTI_RS01855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DESTI_RS01860	COG0336	Belongs to the RNA methyltransferase TrmD family
DESTI_RS01865	COG0335	large ribosomal subunit rRNA binding
DESTI_RS01870	COG1136	(ABC) transporter
DESTI_RS01880	COG0463	Glycosyl transferase, family 2
DESTI_RS01885	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DESTI_RS01895	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DESTI_RS01910	COG0735	belongs to the Fur family
DESTI_RS01920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DESTI_RS01925	COG0131	Imidazoleglycerol-phosphate dehydratase
DESTI_RS01930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DESTI_RS01975	COG0574	Belongs to the PEP-utilizing enzyme family
DESTI_RS01975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DESTI_RS01995	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DESTI_RS02000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DESTI_RS02005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DESTI_RS02010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DESTI_RS02015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DESTI_RS02020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DESTI_RS02025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DESTI_RS02030	COG0586	Pfam SNARE associated Golgi protein
DESTI_RS02050	COG3620	sequence-specific DNA binding
DESTI_RS02055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DESTI_RS02070	COG1012	belongs to the aldehyde dehydrogenase family
DESTI_RS02085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DESTI_RS02130	COG0730	response to heat
DESTI_RS02135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DESTI_RS02140	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS02145	COG1881	PFAM PEBP family protein
DESTI_RS02150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DESTI_RS02155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS02165	COG1309	transcriptional regulator
DESTI_RS02210	COG5012	cobalamin binding
DESTI_RS02240	COG0745	RESPONSE REGULATOR receiver
DESTI_RS02245	COG0745	RESPONSE REGULATOR receiver
DESTI_RS02260	COG1196	nuclear chromosome segregation
DESTI_RS02270	COG0789	Transcriptional regulator
DESTI_RS02285	COG1136	(ABC) transporter
DESTI_RS02285	COG0577	efflux transmembrane transporter activity
DESTI_RS02290	COG0577	efflux transmembrane transporter activity
DESTI_RS02290	COG1136	(ABC) transporter
DESTI_RS02295	COG1136	(ABC) transporter
DESTI_RS02295	COG0577	efflux transmembrane transporter activity
DESTI_RS02300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS02320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DESTI_RS02340	COG1686	Belongs to the peptidase S11 family
DESTI_RS02345	COG5002	protein histidine kinase activity
DESTI_RS02350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DESTI_RS02355	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DESTI_RS02365	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DESTI_RS02375	COG0653	protein targeting
DESTI_RS02405	COG2204	response regulator
DESTI_RS02425	COG1063	alcohol dehydrogenase
DESTI_RS02450	COG2204	response regulator
DESTI_RS02460	COG1295	ribonuclease BN
DESTI_RS02540	COG0776	regulation of translation
DESTI_RS02560	COG1607	acyl-coa hydrolase
DESTI_RS02570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DESTI_RS02575	COG0628	permease
DESTI_RS02580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DESTI_RS02585	COG4535	Mg2 and Co2 transporter CorC
DESTI_RS02605	COG0066	3-isopropylmalate dehydratase activity
DESTI_RS02615	COG1136	(ABC) transporter
DESTI_RS02625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS02630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DESTI_RS02685	COG1032	radical SAM domain protein
DESTI_RS02700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DESTI_RS02710	COG1091	dTDP-4-dehydrorhamnose reductase activity
DESTI_RS02715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DESTI_RS02725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DESTI_RS02725	COG0519	Catalyzes the synthesis of GMP from XMP
DESTI_RS02730	COG2264	protein methyltransferase activity
DESTI_RS02790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DESTI_RS02810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESTI_RS02830	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
DESTI_RS02830	COG1073	alpha beta
DESTI_RS02830	COG3064	Membrane
DESTI_RS02835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DESTI_RS02845	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DESTI_RS02855	COG2945	thiolester hydrolase activity
DESTI_RS02865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DESTI_RS02970	COG4249	Peptidase C14 caspase catalytic subunit p20
DESTI_RS03045	COG0433	COG0433 Predicted ATPase
DESTI_RS03065	COG4221	oxidoreductase activity
DESTI_RS03110	COG1069	ribulokinase activity
DESTI_RS03155	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
DESTI_RS03165	COG1172	Belongs to the binding-protein-dependent transport system permease family
DESTI_RS03170	COG1129	ABC transporter
DESTI_RS03180	COG2183	response to ionizing radiation
DESTI_RS03195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DESTI_RS03200	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DESTI_RS03205	COG2080	2 iron, 2 sulfur cluster binding
DESTI_RS03210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DESTI_RS03210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DESTI_RS03215	COG0450	alkyl hydroperoxide reductase
DESTI_RS03220	COG1309	transcriptional regulator
DESTI_RS03230	COG2204	response regulator
DESTI_RS03240	COG0723	plastoquinol--plastocyanin reductase activity
DESTI_RS03255	COG4263	nitrous-oxide reductase activity
DESTI_RS03275	COG1131	(ABC) transporter
DESTI_RS03320	COG0577	efflux transmembrane transporter activity
DESTI_RS03320	COG1136	(ABC) transporter
DESTI_RS03325	COG1136	(ABC) transporter
DESTI_RS03325	COG0577	efflux transmembrane transporter activity
DESTI_RS03380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DESTI_RS03410	COG0167	dihydroorotate dehydrogenase activity
DESTI_RS03430	COG0674	pyruvate-flavodoxin oxidoreductase activity
DESTI_RS03430	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DESTI_RS03455	COG2223	nitrite transmembrane transporter activity
DESTI_RS03465	COG0310	cobalt ion transport
DESTI_RS03470	COG0310	cobalt ion transport
DESTI_RS03475	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DESTI_RS03500	COG0310	cobalt ion transport
DESTI_RS03530	COG5002	protein histidine kinase activity
DESTI_RS03555	COG0730	response to heat
DESTI_RS03565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DESTI_RS03570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DESTI_RS03595	COG0848	biopolymer transport protein
DESTI_RS03600	COG0811	peptide transport
DESTI_RS03610	COG4771	TonB-dependent receptor
DESTI_RS03615	COG4771	TonB-dependent receptor
DESTI_RS03630	COG4771	TonB-dependent receptor
DESTI_RS03660	COG1247	-acetyltransferase
DESTI_RS03700	COG2181	nitrate reductase activity
DESTI_RS03700	COG0247	lactate metabolic process
DESTI_RS03705	COG0509	glycine decarboxylation via glycine cleavage system
DESTI_RS03715	COG1063	alcohol dehydrogenase
DESTI_RS03725	COG3199	ATP-NAD kinase
DESTI_RS03730	COG0022	dehydrogenase e1 component
DESTI_RS03735	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DESTI_RS03745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DESTI_RS03750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DESTI_RS03755	COG0508	dehydrogenase complex catalyzes the overall conversion of
DESTI_RS03760	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DESTI_RS03795	COG0433	COG0433 Predicted ATPase
DESTI_RS03815	COG1132	(ABC) transporter
DESTI_RS03875	COG3290	protein histidine kinase activity
DESTI_RS03875	COG3829	transcription factor binding
DESTI_RS03880	COG2151	metal-sulfur cluster biosynthetic enzyme
DESTI_RS03900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DESTI_RS03975	COG1518	maintenance of DNA repeat elements
DESTI_RS03980	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DESTI_RS03985	COG0113	porphobilinogen synthase activity
DESTI_RS04000	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DESTI_RS04005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DESTI_RS04010	COG0183	Belongs to the thiolase family
DESTI_RS04045	COG1943	Transposase
DESTI_RS04070	COG3852	Histidine kinase
DESTI_RS04075	COG2204	response regulator
DESTI_RS04105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DESTI_RS04110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DESTI_RS04115	COG0583	DNA-binding transcription factor activity
DESTI_RS04120	COG0163	prenyltransferase activity
DESTI_RS04130	COG0574	Belongs to the PEP-utilizing enzyme family
DESTI_RS04130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DESTI_RS04140	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS04175	COG2204	response regulator
DESTI_RS04180	COG3852	Histidine kinase
DESTI_RS04185	COG1902	pentaerythritol trinitrate reductase activity
DESTI_RS04185	COG0446	pyridine nucleotide-disulphide oxidoreductase
DESTI_RS04190	COG1021	2,3-dihydroxybenzoate-AMP ligase
DESTI_RS04210	COG0411	ABC transporter
DESTI_RS04260	COG2814	Major facilitator Superfamily
DESTI_RS04315	COG1196	nuclear chromosome segregation
DESTI_RS04315	COG1196	nuclear chromosome segregation
DESTI_RS04330	COG0523	cobalamin synthesis protein
DESTI_RS04370	COG5012	cobalamin binding
DESTI_RS04380	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
DESTI_RS04400	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DESTI_RS04415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DESTI_RS04455	COG2197	response regulator
DESTI_RS04475	COG0523	cobalamin synthesis protein
DESTI_RS04485	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DESTI_RS04515	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS04525	COG0411	ABC transporter
DESTI_RS04540	COG0683	leucine binding
DESTI_RS04545	COG2204	response regulator
DESTI_RS04550	COG3852	Histidine kinase
DESTI_RS04560	COG1233	COG1233 Phytoene dehydrogenase and related
DESTI_RS04565	COG1752	Esterase of the alpha-beta hydrolase superfamily
DESTI_RS04590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS04630	COG0673	inositol 2-dehydrogenase activity
DESTI_RS04645	COG0367	asparagine synthase
DESTI_RS04670	COG0471	metal ion transport
DESTI_RS04680	COG1217	gtp-binding protein TYPA
DESTI_RS04705	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS04720	COG0297	glycogen (starch) synthase activity
DESTI_RS04720	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS04760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DESTI_RS04780	COG1785	Belongs to the alkaline phosphatase family
DESTI_RS04785	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DESTI_RS04790	COG0393	Putative heavy-metal-binding
DESTI_RS04825	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DESTI_RS04830	COG1140	nitrate reductase beta subunit
DESTI_RS04835	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DESTI_RS04840	COG2181	nitrate reductase activity
DESTI_RS04850	COG0583	DNA-binding transcription factor activity
DESTI_RS04870	COG1175	transmembrane transport
DESTI_RS04885	COG0393	Putative heavy-metal-binding
DESTI_RS04910	COG5012	cobalamin binding
DESTI_RS04920	COG2814	Major facilitator Superfamily
DESTI_RS04940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DESTI_RS04945	COG1063	alcohol dehydrogenase
DESTI_RS05000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DESTI_RS05020	COG0347	Belongs to the P(II) protein family
DESTI_RS05055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DESTI_RS05060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DESTI_RS05070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DESTI_RS05075	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DESTI_RS05110	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DESTI_RS05140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS05155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DESTI_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
DESTI_RS05165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DESTI_RS05170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DESTI_RS05175	COG0698	ribose 5-phosphate isomerase
DESTI_RS05180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DESTI_RS05210	COG0861	Integral membrane protein TerC family
DESTI_RS05225	COG0784	Response regulator, receiver
DESTI_RS05250	COG0076	glutamate decarboxylase activity
DESTI_RS05255	COG0583	DNA-binding transcription factor activity
DESTI_RS05265	COG0784	Response regulator, receiver
DESTI_RS05280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DESTI_RS05295	COG0481	GTPase activity
DESTI_RS05305	COG0588	phosphoglycerate mutase activity
DESTI_RS05320	COG0589	response to stress
DESTI_RS05330	COG1012	belongs to the aldehyde dehydrogenase family
DESTI_RS05350	COG1102	Psort location Cytoplasmic, score
DESTI_RS05350	COG1904	glucuronate isomerase
DESTI_RS05355	COG0861	Integral membrane protein TerC family
DESTI_RS05400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DESTI_RS05415	COG0686	Belongs to the AlaDH PNT family
DESTI_RS05420	COG0501	Belongs to the peptidase M48B family
DESTI_RS05430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DESTI_RS05435	COG0215	cysteine-tRNA ligase activity
DESTI_RS05440	COG1122	ATPase activity
DESTI_RS05450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESTI_RS05455	COG4796	Type ii and iii secretion system protein
DESTI_RS05470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DESTI_RS05475	COG2226	methyltransferase
DESTI_RS05490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS05500	COG1763	Mo-molybdopterin cofactor biosynthetic process
DESTI_RS05535	COG2264	protein methyltransferase activity
DESTI_RS05545	COG0330	HflC and HflK could
DESTI_RS05550	COG1950	PFAM Membrane protein of
DESTI_RS05555	COG3876	Protein conserved in bacteria
DESTI_RS05575	COG2920	part of a sulfur-relay system
DESTI_RS05585	COG2937	Belongs to the GPAT DAPAT family
DESTI_RS05605	COG2855	membrane
DESTI_RS05610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DESTI_RS05615	COG0105	UTP biosynthetic process
DESTI_RS05620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DESTI_RS05635	COG0138	bifunctional purine biosynthesis protein purh
DESTI_RS05640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DESTI_RS05680	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DESTI_RS05685	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DESTI_RS05700	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DESTI_RS05710	COG1660	Displays ATPase and GTPase activities
DESTI_RS05715	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DESTI_RS05730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DESTI_RS05735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DESTI_RS05750	COG0017	Asparaginyl-tRNA synthetase
DESTI_RS05760	COG1519	Transferase
DESTI_RS05765	COG0009	L-threonylcarbamoyladenylate synthase
DESTI_RS05775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DESTI_RS05800	COG0583	DNA-binding transcription factor activity
DESTI_RS05805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DESTI_RS05840	COG0606	chelatase, subunit chli
DESTI_RS05860	COG2204	response regulator
DESTI_RS05870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DESTI_RS05910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DESTI_RS05915	COG0071	Belongs to the small heat shock protein (HSP20) family
DESTI_RS05925	COG1024	Enoyl-CoA hydratase
DESTI_RS05945	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DESTI_RS05950	COG3177	Filamentation induced by cAMP protein fic
DESTI_RS05955	COG3012	SEC-C Motif Domain Protein
DESTI_RS05960	COG3279	Response regulator of the LytR AlgR family
DESTI_RS05965	COG3275	phosphorelay sensor kinase activity
DESTI_RS05975	COG1966	Carbon starvation protein
DESTI_RS05985	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
DESTI_RS05990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DESTI_RS06000	COG0303	'Molybdopterin
DESTI_RS06005	COG2271	Major facilitator Superfamily
DESTI_RS06035	COG0484	heat shock protein binding
DESTI_RS06040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESTI_RS06060	COG0205	6-phosphofructokinase activity
DESTI_RS06065	COG0012	GTP binding
DESTI_RS06075	COG1595	DNA-templated transcription, initiation
DESTI_RS06080	COG0436	Aminotransferase
DESTI_RS06085	COG0505	Belongs to the CarA family
DESTI_RS06090	COG1686	Belongs to the peptidase S11 family
DESTI_RS06095	COG1469	GTP cyclohydrolase I activity
DESTI_RS06100	COG0720	synthase
DESTI_RS06110	COG1362	aminopeptidase activity
DESTI_RS06145	COG1047	Peptidyl-prolyl cis-trans
DESTI_RS06215	COG0577	efflux transmembrane transporter activity
DESTI_RS06215	COG1136	(ABC) transporter
DESTI_RS06220	COG0500	methyltransferase
DESTI_RS06260	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DESTI_RS06275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DESTI_RS06280	COG0359	binds to the 23S rRNA
DESTI_RS06285	COG0305	Participates in initiation and elongation during chromosome replication
DESTI_RS06290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESTI_RS06295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DESTI_RS06300	COG0124	histidyl-tRNA synthetase
DESTI_RS06330	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DESTI_RS06335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DESTI_RS06335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DESTI_RS06355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DESTI_RS06375	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS06390	COG1653	transport
DESTI_RS06430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DESTI_RS06455	COG0483	inositol monophosphate 1-phosphatase activity
DESTI_RS06460	COG1570	exodeoxyribonuclease VII activity
DESTI_RS06500	COG0003	Pfam Anion-transporting ATPase
DESTI_RS06510	COG1012	belongs to the aldehyde dehydrogenase family
DESTI_RS06515	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS06560	COG0517	IMP dehydrogenase activity
DESTI_RS06580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DESTI_RS06585	COG1598	PFAM Uncharacterised protein family UPF0150
DESTI_RS06590	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DESTI_RS06605	COG5000	phosphorelay sensor kinase activity
DESTI_RS06610	COG0077	Prephenate dehydratase
DESTI_RS06610	COG1605	Chorismate mutase
DESTI_RS06615	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DESTI_RS06630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DESTI_RS06635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DESTI_RS06640	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DESTI_RS06690	COG0792	nuclease activity
DESTI_RS06715	COG0321	lipoyl(octanoyl) transferase activity
DESTI_RS06750	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS06760	COG2856	Zn peptidase
DESTI_RS06820	COG1022	Amp-dependent synthetase and ligase
DESTI_RS06840	COG0183	Belongs to the thiolase family
DESTI_RS06910	COG3301	Polysulphide reductase, NrfD
DESTI_RS06915	COG0437	4 iron, 4 sulfur cluster binding
DESTI_RS06935	COG3655	Transcriptional regulator
DESTI_RS06940	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DESTI_RS06965	COG1100	Small GTP-binding protein
DESTI_RS06985	COG5002	protein histidine kinase activity
DESTI_RS06990	COG0537	adenosine 5'-monophosphoramidase activity
DESTI_RS06995	COG0537	adenosine 5'-monophosphoramidase activity
DESTI_RS07005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESTI_RS07010	COG0444	Belongs to the ABC transporter superfamily
DESTI_RS07045	COG3604	Transcriptional regulator
DESTI_RS07050	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DESTI_RS07060	COG2255	four-way junction helicase activity
DESTI_RS07065	COG0217	transcriptional regulatory protein
DESTI_RS07080	COG0308	aminopeptidase N
DESTI_RS07100	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DESTI_RS07120	COG0632	four-way junction helicase activity
DESTI_RS07125	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DESTI_RS07135	COG0446	pyridine nucleotide-disulphide oxidoreductase
DESTI_RS07140	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DESTI_RS07145	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DESTI_RS07190	COG0653	protein targeting
DESTI_RS07210	COG1233	COG1233 Phytoene dehydrogenase and related
DESTI_RS07215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DESTI_RS07240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DESTI_RS07260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DESTI_RS07270	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DESTI_RS07280	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS07300	COG0655	NAD(P)H dehydrogenase (quinone) activity
DESTI_RS07305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DESTI_RS07310	COG0509	glycine decarboxylation via glycine cleavage system
DESTI_RS07315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DESTI_RS07320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DESTI_RS07345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DESTI_RS07395	COG1024	Enoyl-CoA hydratase
DESTI_RS07420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DESTI_RS07425	COG1181	Belongs to the D-alanine--D-alanine ligase family
DESTI_RS07450	COG1722	exodeoxyribonuclease VII activity
DESTI_RS07460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DESTI_RS07480	COG3852	Histidine kinase
DESTI_RS07495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DESTI_RS07525	COG2223	nitrite transmembrane transporter activity
DESTI_RS07545	COG3321	synthase
DESTI_RS07545	COG0604	alcohol dehydrogenase
DESTI_RS07565	COG2226	methyltransferase
DESTI_RS07570	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS07580	COG1024	Enoyl-CoA hydratase
DESTI_RS07590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DESTI_RS07595	COG2223	nitrite transmembrane transporter activity
DESTI_RS07610	COG0427	acetyl-CoA hydrolase
DESTI_RS07630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DESTI_RS07635	COG2205	protein histidine kinase activity
DESTI_RS07670	COG3104	oligopeptide transport
DESTI_RS07690	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DESTI_RS07690	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DESTI_RS07700	COG0351	phosphomethylpyrimidine kinase
DESTI_RS07700	COG0352	thiamine-phosphate diphosphorylase activity
DESTI_RS07705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DESTI_RS07710	COG1215	transferase activity, transferring glycosyl groups
DESTI_RS07720	COG1530	ribonuclease E activity
DESTI_RS07740	COG1309	transcriptional regulator
DESTI_RS07775	COG2264	protein methyltransferase activity
DESTI_RS07785	COG2221	Nitrite and sulphite reductase 4Fe-4S
DESTI_RS07790	COG2221	Nitrite and sulphite reductase 4Fe-4S
DESTI_RS07800	COG1797	cobyrinic acid a,c-diamide synthase activity
DESTI_RS07835	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DESTI_RS07860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DESTI_RS07875	COG0443	Heat shock 70 kDa protein
DESTI_RS07880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DESTI_RS07885	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS07890	COG1309	transcriptional regulator
DESTI_RS07895	COG1024	Enoyl-CoA hydratase
DESTI_RS07895	COG1250	3-hydroxyacyl-CoA dehydrogenase
DESTI_RS07900	COG0183	Belongs to the thiolase family
DESTI_RS07905	COG1720	tRNA m6t6A37 methyltransferase activity
DESTI_RS07910	COG0577	efflux transmembrane transporter activity
DESTI_RS07920	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DESTI_RS07930	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
DESTI_RS07970	COG0247	lactate metabolic process
DESTI_RS07975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DESTI_RS07985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESTI_RS07990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESTI_RS08000	COG2414	aldehyde ferredoxin oxidoreductase
DESTI_RS08010	COG0367	asparagine synthase
DESTI_RS08015	COG3829	transcription factor binding
DESTI_RS08015	COG3290	protein histidine kinase activity
DESTI_RS08020	COG0659	secondary active sulfate transmembrane transporter activity
DESTI_RS08035	COG0427	acetyl-CoA hydrolase
DESTI_RS08050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DESTI_RS08070	COG0776	regulation of translation
DESTI_RS08085	COG1191	sigma factor activity
DESTI_RS08090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DESTI_RS08100	COG1067	ATP-dependent peptidase activity
DESTI_RS08110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DESTI_RS08115	COG0557	exoribonuclease II activity
DESTI_RS08120	COG2815	serine threonine protein kinase
DESTI_RS08120	COG0515	serine threonine protein kinase
DESTI_RS08125	COG0494	nUDIX hydrolase
DESTI_RS08130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESTI_RS08155	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DESTI_RS08170	COG0724	RNA recognition motif
DESTI_RS08185	COG0183	Belongs to the thiolase family
DESTI_RS08190	COG1028	Short-chain dehydrogenase reductase Sdr
DESTI_RS08195	COG1028	Short-chain dehydrogenase reductase Sdr
DESTI_RS08200	COG1797	cobyrinic acid a,c-diamide synthase activity
DESTI_RS08205	COG1199	ATP-dependent helicase activity
DESTI_RS08210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DESTI_RS08215	COG1127	ABC transporter
DESTI_RS08230	COG0745	RESPONSE REGULATOR receiver
DESTI_RS08235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DESTI_RS08245	COG1309	transcriptional regulator
DESTI_RS08250	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DESTI_RS08250	COG0517	IMP dehydrogenase activity
DESTI_RS08265	COG2204	response regulator
DESTI_RS08285	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DESTI_RS08290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DESTI_RS08305	COG0492	ferredoxin-NADP+ reductase activity
DESTI_RS08325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DESTI_RS08335	COG1420	regulation of RNA biosynthetic process
DESTI_RS08365	COG0303	'Molybdopterin
DESTI_RS08375	COG0517	IMP dehydrogenase activity
DESTI_RS08375	COG1994	Peptidase M50
DESTI_RS08380	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DESTI_RS08380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DESTI_RS08385	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DESTI_RS08385	COG3608	succinylglutamate desuccinylase aspartoacylase
DESTI_RS08410	COG2205	protein histidine kinase activity
DESTI_RS08435	COG1640	4-alpha-glucanotransferase
DESTI_RS08440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DESTI_RS08445	COG0443	Heat shock 70 kDa protein
DESTI_RS08455	COG2264	protein methyltransferase activity
DESTI_RS08460	COG0436	Aminotransferase
DESTI_RS08470	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DESTI_RS08475	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DESTI_RS08480	COG1943	Transposase
DESTI_RS08500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DESTI_RS08520	COG1193	negative regulation of DNA recombination
DESTI_RS08535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESTI_RS08545	COG2089	acid synthase
DESTI_RS08565	COG0784	Response regulator, receiver
DESTI_RS08575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DESTI_RS08585	COG1994	Peptidase M50
DESTI_RS08585	COG0517	IMP dehydrogenase activity
DESTI_RS08605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESTI_RS08630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DESTI_RS08630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DESTI_RS08635	COG1090	epimerase
DESTI_RS08640	COG1595	DNA-templated transcription, initiation
DESTI_RS08690	COG0437	4 iron, 4 sulfur cluster binding
DESTI_RS08695	COG0243	molybdopterin cofactor binding
DESTI_RS08710	COG0745	RESPONSE REGULATOR receiver
DESTI_RS08720	COG3852	Histidine kinase
DESTI_RS08730	COG0167	dihydroorotate dehydrogenase activity
DESTI_RS08740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DESTI_RS08775	COG1918	ferrous iron import across plasma membrane
DESTI_RS08775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DESTI_RS08790	COG2204	response regulator
DESTI_RS08795	COG2885	chlorophyll binding
DESTI_RS08795	COG3047	cAMP biosynthetic process
DESTI_RS08825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DESTI_RS08840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESTI_RS08845	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DESTI_RS08865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DESTI_RS08965	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DESTI_RS08970	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DESTI_RS08980	COG2226	methyltransferase
DESTI_RS08990	COG3634	alkyl hydroperoxide reductase activity
DESTI_RS09010	COG3383	formate dehydrogenase (NAD+) activity
DESTI_RS09015	COG3383	formate dehydrogenase (NAD+) activity
DESTI_RS09025	COG0437	4 iron, 4 sulfur cluster binding
DESTI_RS09030	COG3383	formate dehydrogenase (NAD+) activity
DESTI_RS09030	COG0243	molybdopterin cofactor binding
DESTI_RS09045	COG2186	Transcriptional regulator
DESTI_RS09050	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS09055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DESTI_RS09070	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS09130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DESTI_RS09145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DESTI_RS09150	COG2086	electron transfer activity
DESTI_RS09155	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DESTI_RS09160	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS09165	COG1802	Transcriptional regulator
DESTI_RS09170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DESTI_RS09175	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DESTI_RS09175	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DESTI_RS09190	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DESTI_RS09230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DESTI_RS09250	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DESTI_RS09250	COG3608	succinylglutamate desuccinylase aspartoacylase
DESTI_RS09255	COG0726	polysaccharide deacetylase
DESTI_RS09270	COG4149	molybdate abc transporter
DESTI_RS09275	COG0725	ABC transporter, periplasmic molybdate-binding protein
DESTI_RS09305	COG3842	ATPase activity
DESTI_RS09315	COG0745	RESPONSE REGULATOR receiver
DESTI_RS09325	COG0704	Plays a role in the regulation of phosphate uptake
DESTI_RS09330	COG2204	response regulator
DESTI_RS09335	COG5002	protein histidine kinase activity
DESTI_RS09340	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DESTI_RS09350	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DESTI_RS09355	COG2205	protein histidine kinase activity
DESTI_RS09365	COG0517	IMP dehydrogenase activity
DESTI_RS09365	COG0516	GMP reductase activity
DESTI_RS09370	COG0667	Aldo Keto reductase
DESTI_RS09400	COG4251	negative regulation of phosphorylation
DESTI_RS09440	COG0531	amino acid
DESTI_RS09450	COG1053	succinate dehydrogenase
DESTI_RS09495	COG3604	Transcriptional regulator
DESTI_RS09505	COG2721	sulfolactate sulfo-lyase activity
DESTI_RS09535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DESTI_RS09545	COG0784	Response regulator, receiver
DESTI_RS09565	COG2414	aldehyde ferredoxin oxidoreductase
DESTI_RS09575	COG2181	nitrate reductase activity
DESTI_RS09575	COG0247	lactate metabolic process
DESTI_RS09615	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DESTI_RS09620	COG0109	protoheme IX farnesyltransferase activity
DESTI_RS09625	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DESTI_RS09630	COG1845	cytochrome c oxidase, subunit III
DESTI_RS09635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DESTI_RS09640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DESTI_RS09665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DESTI_RS09670	COG4178	(ABC) transporter
DESTI_RS09675	COG0730	response to heat
DESTI_RS09680	COG0586	Pfam SNARE associated Golgi protein
DESTI_RS09685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESTI_RS09695	COG2414	aldehyde ferredoxin oxidoreductase
DESTI_RS09700	COG0437	4 iron, 4 sulfur cluster binding
DESTI_RS09720	COG1902	pentaerythritol trinitrate reductase activity
DESTI_RS09740	COG0589	response to stress
DESTI_RS09760	COG0517	IMP dehydrogenase activity
DESTI_RS09765	COG0589	response to stress
DESTI_RS09810	COG2207	Transcriptional regulator
DESTI_RS09835	COG3604	Transcriptional regulator
DESTI_RS09850	COG0489	protein tyrosine kinase activity
DESTI_RS09925	COG2358	TRAP transporter, solute receptor (TAXI family
DESTI_RS09990	COG1028	Short-chain dehydrogenase reductase Sdr
DESTI_RS09995	COG1454	alcohol dehydrogenase
DESTI_RS10005	COG0411	ABC transporter
DESTI_RS10010	COG4177	L-phenylalanine transmembrane transporter activity
DESTI_RS10025	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS10040	COG0662	Cupin 2, conserved barrel domain protein
DESTI_RS10105	COG1028	Short-chain dehydrogenase reductase Sdr
DESTI_RS10115	COG3437	response regulator, receiver
DESTI_RS10120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DESTI_RS10125	COG2814	Major facilitator Superfamily
DESTI_RS10140	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DESTI_RS10170	COG0523	cobalamin synthesis protein
DESTI_RS10190	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DESTI_RS10200	COG2204	response regulator
DESTI_RS10220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DESTI_RS10245	COG1294	oxidase, subunit
DESTI_RS10250	COG1271	oxidase subunit
DESTI_RS10265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DESTI_RS10290	COG0519	Catalyzes the synthesis of GMP from XMP
DESTI_RS10310	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS10325	COG0247	lactate metabolic process
DESTI_RS10325	COG2181	nitrate reductase activity
DESTI_RS10340	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DESTI_RS10370	COG0589	response to stress
DESTI_RS10420	COG0509	glycine decarboxylation via glycine cleavage system
DESTI_RS10425	COG2226	methyltransferase
DESTI_RS10495	COG0477	Major facilitator Superfamily
DESTI_RS10500	COG0646	methionine synthase
DESTI_RS10500	COG1410	methionine synthase
DESTI_RS10510	COG3290	protein histidine kinase activity
DESTI_RS10510	COG3829	transcription factor binding
DESTI_RS10515	COG5012	cobalamin binding
DESTI_RS10525	COG0477	Major facilitator Superfamily
DESTI_RS10560	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DESTI_RS10565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DESTI_RS10570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DESTI_RS10575	COG0698	ribose 5-phosphate isomerase
DESTI_RS10585	COG1566	PFAM secretion protein HlyD family protein
DESTI_RS10590	COG2814	Major facilitator Superfamily
DESTI_RS10625	COG0439	Biotin carboxylase
DESTI_RS10645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DESTI_RS10650	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DESTI_RS10655	COG1172	Belongs to the binding-protein-dependent transport system permease family
DESTI_RS10660	COG1129	ABC transporter
DESTI_RS10665	COG1879	ABC-type sugar transport system periplasmic component
DESTI_RS10675	COG3829	transcription factor binding
DESTI_RS10675	COG3290	protein histidine kinase activity
DESTI_RS10695	COG2814	Major facilitator Superfamily
DESTI_RS10715	COG3119	arylsulfatase activity
DESTI_RS10720	COG1024	Enoyl-CoA hydratase
DESTI_RS10720	COG1250	3-hydroxyacyl-CoA dehydrogenase
DESTI_RS10725	COG0183	Belongs to the thiolase family
DESTI_RS10730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DESTI_RS10740	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS10765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DESTI_RS10775	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS10800	COG0559	Belongs to the binding-protein-dependent transport system permease family
DESTI_RS10805	COG1028	Short-chain dehydrogenase reductase Sdr
DESTI_RS10810	COG1309	transcriptional regulator
DESTI_RS10820	COG1250	3-hydroxyacyl-CoA dehydrogenase
DESTI_RS10825	COG0183	Belongs to the thiolase family
DESTI_RS10980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DESTI_RS11085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DESTI_RS11095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DESTI_RS11100	COG1120	ATPase activity
DESTI_RS11175	COG0247	lactate metabolic process
DESTI_RS11180	COG0277	FAD linked oxidase domain protein
DESTI_RS11185	COG2186	Transcriptional regulator
DESTI_RS11190	COG1620	l-lactate permease
DESTI_RS11250	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS11255	COG2814	Major facilitator Superfamily
DESTI_RS11260	COG1024	Enoyl-CoA hydratase
DESTI_RS11265	COG0183	Belongs to the thiolase family
DESTI_RS11280	COG0511	ligase activity, forming carbon-carbon bonds
DESTI_RS11285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DESTI_RS11315	COG1695	Transcriptional regulator
DESTI_RS11340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DESTI_RS11345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS11350	COG0631	protein serine/threonine phosphatase activity
DESTI_RS11355	COG0515	serine threonine protein kinase
DESTI_RS11355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DESTI_RS11395	COG2186	Transcriptional regulator
DESTI_RS11485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DESTI_RS11540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DESTI_RS11545	COG1408	metallophosphoesterase
DESTI_RS11585	COG1595	DNA-templated transcription, initiation
DESTI_RS11605	COG1215	transferase activity, transferring glycosyl groups
DESTI_RS11610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DESTI_RS11620	COG0247	lactate metabolic process
DESTI_RS11625	COG0537	adenosine 5'-monophosphoramidase activity
DESTI_RS11630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DESTI_RS11660	COG0546	phosphoglycolate phosphatase activity
DESTI_RS11675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DESTI_RS11700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DESTI_RS11705	COG2176	DNA-directed DNA polymerase activity
DESTI_RS11725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DESTI_RS11740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DESTI_RS11775	COG0617	tRNA 3'-terminal CCA addition
DESTI_RS11775	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DESTI_RS11775	COG3620	sequence-specific DNA binding
DESTI_RS11780	COG5016	pyruvate
DESTI_RS11780	COG0511	ligase activity, forming carbon-carbon bonds
DESTI_RS11835	COG4717	serine-type aminopeptidase activity
DESTI_RS11840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESTI_RS11890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DESTI_RS11905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DESTI_RS11915	COG1192	Involved in chromosome partitioning
DESTI_RS11930	COG1073	alpha beta
DESTI_RS11930	COG2226	methyltransferase
DESTI_RS11965	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DESTI_RS11985	COG3604	Transcriptional regulator
DESTI_RS12005	COG5002	protein histidine kinase activity
DESTI_RS12050	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DESTI_RS12055	COG1695	Transcriptional regulator
DESTI_RS12070	COG1971	Probably functions as a manganese efflux pump
DESTI_RS12155	COG0493	'glutamate synthase
DESTI_RS12160	COG0543	2 iron, 2 sulfur cluster binding
DESTI_RS12180	COG1994	Peptidase M50
DESTI_RS12185	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DESTI_RS12200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DESTI_RS12210	COG0517	IMP dehydrogenase activity
DESTI_RS12210	COG0516	GMP reductase activity
DESTI_RS12215	COG1691	(AIR) carboxylase
DESTI_RS12240	COG1250	3-hydroxyacyl-CoA dehydrogenase
DESTI_RS12245	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS12260	COG0535	radical SAM domain protein
DESTI_RS12275	COG0668	transmembrane transport
DESTI_RS12295	COG1104	cysteine desulfurase activity
DESTI_RS12300	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DESTI_RS12345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DESTI_RS12350	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DESTI_RS12355	COG4619	ABC transporter
DESTI_RS12360	COG0390	transport system, permease component
DESTI_RS12365	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS12375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DESTI_RS12410	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DESTI_RS12425	COG1473	amidohydrolase
DESTI_RS12440	COG0517	IMP dehydrogenase activity
DESTI_RS12470	COG2095	MarC family integral membrane protein
DESTI_RS12505	COG3119	arylsulfatase activity
DESTI_RS12515	COG3119	arylsulfatase activity
DESTI_RS12545	COG1205	dead DEAH box helicase
DESTI_RS12545	COG1111	helicase
DESTI_RS12565	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
DESTI_RS12570	COG1151	hydroxylamine reductase activity
DESTI_RS12615	COG0237	dephospho-CoA kinase activity
DESTI_RS12635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DESTI_RS12640	COG0280	phosphate acetyltransferase
DESTI_RS12650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DESTI_RS12660	COG4974	Belongs to the 'phage' integrase family
DESTI_RS12670	COG0577	efflux transmembrane transporter activity
DESTI_RS12675	COG1013	pyruvate-flavodoxin oxidoreductase activity
DESTI_RS12680	COG0674	pyruvate-flavodoxin oxidoreductase activity
DESTI_RS12685	COG1144	Oxidoreductase
DESTI_RS12700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DESTI_RS12710	COG0437	4 iron, 4 sulfur cluster binding
DESTI_RS12720	COG1704	LemA family
DESTI_RS12730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DESTI_RS12735	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DESTI_RS12735	COG0517	IMP dehydrogenase activity
DESTI_RS12740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DESTI_RS12755	COG1561	YicC-like family, N-terminal region
DESTI_RS12760	COG1758	RNA polymerase activity
DESTI_RS12765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DESTI_RS12805	COG0419	ATPase involved in DNA repair
DESTI_RS12815	COG1703	isobutyryl-CoA mutase activity
DESTI_RS12815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DESTI_RS12815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DESTI_RS12830	COG1546	Belongs to the CinA family
DESTI_RS12830	COG1058	Belongs to the CinA family
DESTI_RS12835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DESTI_RS12835	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DESTI_RS12850	COG0535	radical SAM domain protein
DESTI_RS12860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DESTI_RS12865	COG0459	protein refolding
DESTI_RS12875	COG0540	Belongs to the ATCase OTCase family
DESTI_RS12880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DESTI_RS12885	COG0693	protein deglycase activity
DESTI_RS12925	COG1648	precorrin-2 dehydrogenase activity
DESTI_RS12925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DESTI_RS12930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DESTI_RS12935	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DESTI_RS12940	COG0181	hydroxymethylbilane synthase activity
DESTI_RS12955	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS12980	COG2239	Acts as a magnesium transporter
DESTI_RS12985	COG1914	H( )-stimulated, divalent metal cation uptake system
DESTI_RS12990	COG2226	methyltransferase
DESTI_RS12995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DESTI_RS13005	COG0372	Belongs to the citrate synthase family
DESTI_RS13015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DESTI_RS13030	COG0210	DNA helicase
DESTI_RS13050	COG0445	tRNA wobble uridine modification
DESTI_RS13070	COG1333	cytochrome c biogenesis protein
DESTI_RS13075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DESTI_RS13080	COG1472	Belongs to the glycosyl hydrolase 3 family
DESTI_RS13085	COG2205	protein histidine kinase activity
DESTI_RS13115	COG1410	methionine synthase
DESTI_RS13115	COG0646	methionine synthase
DESTI_RS13160	COG0714	Associated with various cellular activities
DESTI_RS13170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS13175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DESTI_RS13190	COG3191	aminopeptidase activity
DESTI_RS13200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DESTI_RS13315	COG1074	ATP-dependent DNA helicase activity
DESTI_RS13320	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DESTI_RS13340	COG0535	radical SAM domain protein
DESTI_RS13380	COG0590	tRNA wobble adenosine to inosine editing
DESTI_RS13385	COG0129	dihydroxy-acid dehydratase activity
DESTI_RS13400	COG1530	ribonuclease E activity
DESTI_RS13405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DESTI_RS13410	COG0251	oxidation-reduction process
DESTI_RS13430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DESTI_RS13440	COG0205	6-phosphofructokinase activity
DESTI_RS13455	COG1950	PFAM Membrane protein of
DESTI_RS13470	COG2204	response regulator
DESTI_RS13475	COG4191	Histidine kinase
DESTI_RS13485	COG4191	Histidine kinase
DESTI_RS13515	COG0204	Acyl-transferase
DESTI_RS13520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS13525	COG0577	efflux transmembrane transporter activity
DESTI_RS13525	COG1136	(ABC) transporter
DESTI_RS13540	COG0482	sulfurtransferase activity
DESTI_RS13555	COG1215	transferase activity, transferring glycosyl groups
DESTI_RS13575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DESTI_RS13625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DESTI_RS13630	COG0148	phosphopyruvate hydratase activity
DESTI_RS13640	COG2172	sigma factor antagonist activity
DESTI_RS13645	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESTI_RS13650	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESTI_RS13655	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESTI_RS13670	COG0613	PHP domain protein
DESTI_RS13675	COG4191	Histidine kinase
DESTI_RS13675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESTI_RS13695	COG3383	formate dehydrogenase (NAD+) activity
DESTI_RS13700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DESTI_RS13705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESTI_RS13710	COG0839	Belongs to the complex I subunit 6 family
DESTI_RS13730	COG1007	ATP synthesis coupled electron transport
DESTI_RS13735	COG0047	phosphoribosylformylglycinamidine synthase activity
DESTI_RS13740	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DESTI_RS13750	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DESTI_RS13755	COG0123	including yeast histone deacetylase and acetoin utilization protein
DESTI_RS13760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DESTI_RS13780	COG1846	Transcriptional regulator
DESTI_RS13780	COG0456	acetyltransferase
DESTI_RS13810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESTI_RS13895	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DESTI_RS13900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DESTI_RS13910	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS13915	COG3724	N-succinylarginine dihydrolase activity
DESTI_RS13940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESTI_RS13965	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DESTI_RS13975	COG1132	(ABC) transporter
DESTI_RS13980	COG0367	asparagine synthase
DESTI_RS13985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DESTI_RS14000	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS14000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DESTI_RS14020	COG1216	Glycosyl transferase, family 2
DESTI_RS14030	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS14035	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS14045	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
DESTI_RS14050	COG1028	Short-chain dehydrogenase reductase Sdr
DESTI_RS14055	COG0673	inositol 2-dehydrogenase activity
DESTI_RS14065	COG1086	Polysaccharide biosynthesis protein
DESTI_RS14135	COG3642	lipopolysaccharide core region biosynthetic process
DESTI_RS14140	COG1216	Glycosyl transferase, family 2
DESTI_RS14140	COG0463	Glycosyl transferase, family 2
DESTI_RS14150	COG2835	tetraacyldisaccharide 4'-kinase activity
DESTI_RS14215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DESTI_RS14220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DESTI_RS14240	COG0842	Transport permease protein
DESTI_RS14245	COG1131	(ABC) transporter
DESTI_RS14280	COG4464	protein tyrosine phosphatase activity
DESTI_RS14290	COG0728	peptidoglycan biosynthetic process
DESTI_RS14295	COG0268	Binds directly to 16S ribosomal RNA
DESTI_RS14305	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DESTI_RS14335	COG1254	Belongs to the acylphosphatase family
DESTI_RS14340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DESTI_RS14400	COG1022	Amp-dependent synthetase and ligase
DESTI_RS14415	COG1024	Enoyl-CoA hydratase
DESTI_RS14420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESTI_RS14425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DESTI_RS14445	COG4656	Part of a membrane complex involved in electron transport
DESTI_RS14450	COG4658	electron transport chain
DESTI_RS14455	COG4659	FMN binding
DESTI_RS14460	COG4660	Part of a membrane complex involved in electron transport
DESTI_RS14465	COG4657	Part of a membrane complex involved in electron transport
DESTI_RS14470	COG2878	Part of a membrane complex involved in electron transport
DESTI_RS14480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DESTI_RS14485	COG0315	cyclic pyranopterin monophosphate synthase activity
DESTI_RS14530	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DESTI_RS14555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DESTI_RS14560	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DESTI_RS14565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DESTI_RS14570	COG1454	alcohol dehydrogenase
DESTI_RS14595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DESTI_RS14625	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DESTI_RS14635	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DESTI_RS14665	COG0069	glutamate synthase activity
DESTI_RS14670	COG0069	glutamate synthase activity
DESTI_RS14685	COG1250	3-hydroxyacyl-CoA dehydrogenase
DESTI_RS14685	COG1024	Enoyl-CoA hydratase
DESTI_RS14690	COG0183	Belongs to the thiolase family
DESTI_RS14695	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS14700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESTI_RS14705	COG0535	radical SAM domain protein
DESTI_RS14710	COG0113	porphobilinogen synthase activity
DESTI_RS14735	COG4106	trans-aconitate 2-methyltransferase activity
DESTI_RS14745	COG0542	response to heat
DESTI_RS14780	COG0346	lactoylglutathione lyase activity
DESTI_RS14785	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DESTI_RS14795	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DESTI_RS14795	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DESTI_RS14805	COG0700	Nucleoside recognition
DESTI_RS14810	COG2715	membrane protein required for spore maturation
DESTI_RS14825	COG1131	(ABC) transporter
DESTI_RS14865	COG1104	cysteine desulfurase activity
DESTI_RS14910	COG0527	aspartate kinase activity
DESTI_RS14915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESTI_RS14930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DESTI_RS14960	COG1024	Enoyl-CoA hydratase
DESTI_RS14965	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS14985	COG0425	Belongs to the sulfur carrier protein TusA family
DESTI_RS15020	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS15030	COG3321	synthase
DESTI_RS15030	COG1028	Short-chain dehydrogenase reductase Sdr
DESTI_RS15030	COG0604	alcohol dehydrogenase
DESTI_RS15065	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DESTI_RS15090	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
DESTI_RS15095	COG1040	competence protein
DESTI_RS15180	COG0436	Aminotransferase
DESTI_RS15190	COG0653	protein targeting
DESTI_RS15195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DESTI_RS15205	COG2226	methyltransferase
DESTI_RS15210	COG0193	aminoacyl-tRNA hydrolase activity
DESTI_RS15220	COG5000	phosphorelay sensor kinase activity
DESTI_RS15235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DESTI_RS15240	COG0613	PHP domain protein
DESTI_RS15250	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DESTI_RS15255	COG2204	response regulator
DESTI_RS15260	COG1619	proteins homologs of microcin C7 resistance protein MccF
DESTI_RS15280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DESTI_RS15285	COG0741	lytic transglycosylase activity
DESTI_RS15290	COG3852	Histidine kinase
DESTI_RS15300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DESTI_RS15310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DESTI_RS15315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DESTI_RS15320	COG0019	diaminopimelate decarboxylase activity
DESTI_RS15330	COG0165	Argininosuccinate lyase
DESTI_RS15335	COG0137	argininosuccinate synthase activity
DESTI_RS15345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DESTI_RS15350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DESTI_RS15365	COG0631	protein serine/threonine phosphatase activity
DESTI_RS15390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESTI_RS15405	COG0358	DNA primase activity
DESTI_RS15410	COG1193	negative regulation of DNA recombination
DESTI_RS15415	COG0107	imidazoleglycerol-phosphate synthase activity
DESTI_RS15420	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DESTI_RS15435	COG1028	Short-chain dehydrogenase reductase Sdr
DESTI_RS15450	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS15475	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DESTI_RS15495	COG1663	tetraacyldisaccharide 4'-kinase activity
DESTI_RS15500	COG1132	(ABC) transporter
DESTI_RS15510	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DESTI_RS15515	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DESTI_RS15525	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DESTI_RS15530	COG1136	(ABC) transporter
DESTI_RS15540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DESTI_RS15545	COG1459	type II secretion system
DESTI_RS15555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DESTI_RS15570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DESTI_RS15575	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DESTI_RS15600	COG0142	geranyltranstransferase activity
DESTI_RS15610	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DESTI_RS15615	COG0717	Belongs to the dCTP deaminase family
DESTI_RS15625	COG1331	Highly conserved protein containing a thioredoxin domain
DESTI_RS15635	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DESTI_RS15695	COG0484	heat shock protein binding
DESTI_RS15700	COG1032	radical SAM domain protein
DESTI_RS15705	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DESTI_RS15720	COG2204	response regulator
DESTI_RS15725	COG2205	protein histidine kinase activity
DESTI_RS15740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DESTI_RS15755	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS15790	COG0156	8-amino-7-oxononanoate synthase activity
DESTI_RS15795	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DESTI_RS15815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DESTI_RS15820	COG3383	formate dehydrogenase (NAD+) activity
DESTI_RS15825	COG3383	formate dehydrogenase (NAD+) activity
DESTI_RS15845	COG1598	PFAM Uncharacterised protein family UPF0150
DESTI_RS15850	COG2442	InterPro IPR007367
DESTI_RS15855	COG3103	Sh3 type 3 domain protein
DESTI_RS15855	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESTI_RS15855	COG4991	sh3 domain protein
DESTI_RS15870	COG0784	Response regulator, receiver
DESTI_RS15885	COG0837	glucose binding
DESTI_RS15890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DESTI_RS15895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DESTI_RS15915	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DESTI_RS15940	COG0456	acetyltransferase
DESTI_RS15945	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DESTI_RS15950	COG0534	Mate efflux family protein
DESTI_RS15955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DESTI_RS15960	COG4191	Histidine kinase
DESTI_RS15980	COG1122	ATPase activity
DESTI_RS15995	COG0402	S-adenosylhomocysteine deaminase activity
DESTI_RS16010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DESTI_RS16025	COG5012	cobalamin binding
DESTI_RS16045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DESTI_RS16060	COG0247	lactate metabolic process
DESTI_RS16080	COG0243	molybdopterin cofactor binding
DESTI_RS16145	COG0163	prenyltransferase activity
DESTI_RS16150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DESTI_RS16155	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DESTI_RS16160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DESTI_RS16165	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DESTI_RS16170	COG0473	3-isopropylmalate dehydrogenase activity
DESTI_RS16170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DESTI_RS16175	COG0473	3-isopropylmalate dehydrogenase activity
DESTI_RS16175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DESTI_RS16180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DESTI_RS16190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DESTI_RS16195	COG0167	dihydroorotate dehydrogenase activity
DESTI_RS16210	COG1335	isochorismatase
DESTI_RS16235	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS16245	COG3604	Transcriptional regulator
DESTI_RS16255	COG2721	sulfolactate sulfo-lyase activity
DESTI_RS16275	COG3181	Tripartite tricarboxylate transporter family receptor
DESTI_RS16285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DESTI_RS16330	COG0243	molybdopterin cofactor binding
DESTI_RS16335	COG1846	Transcriptional regulator
DESTI_RS16355	COG0398	Pfam SNARE associated Golgi protein
DESTI_RS16360	COG4232	protein-disulfide reductase activity
DESTI_RS16385	COG0709	Synthesizes selenophosphate from selenide and ATP
DESTI_RS16390	COG3320	Male sterility
DESTI_RS16390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DESTI_RS16420	COG0534	Mate efflux family protein
DESTI_RS16425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DESTI_RS16430	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DESTI_RS16440	COG2204	response regulator
DESTI_RS16445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESTI_RS16570	COG0463	Glycosyl transferase, family 2
DESTI_RS16585	COG3481	metal-dependent phosphohydrolase, HD sub domain
DESTI_RS16590	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DESTI_RS16595	COG1473	amidohydrolase
DESTI_RS16610	COG1032	radical SAM domain protein
DESTI_RS16630	COG0552	protein localization to endoplasmic reticulum
DESTI_RS16635	COG0432	Pfam Uncharacterised protein family UPF0047
DESTI_RS16640	COG0328	RNA-DNA hybrid ribonuclease activity
DESTI_RS16650	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DESTI_RS16655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DESTI_RS16660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DESTI_RS16675	COG1272	protein, Hemolysin III
DESTI_RS16685	COG4771	TonB-dependent receptor
DESTI_RS16710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DESTI_RS16730	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DESTI_RS16975	COG0071	Belongs to the small heat shock protein (HSP20) family
DESTI_RS16985	COG0071	Belongs to the small heat shock protein (HSP20) family
DESTI_RS17000	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DESTI_RS17000	COG0662	Cupin 2, conserved barrel domain protein
DESTI_RS17025	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
DESTI_RS17030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DESTI_RS17030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DESTI_RS17205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DESTI_RS17205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DESTI_RS17355	COG1053	succinate dehydrogenase
DESTI_RS17370	COG1473	amidohydrolase
DESTI_RS17380	COG3829	transcription factor binding
DESTI_RS17420	COG0784	Response regulator, receiver
DESTI_RS17460	COG1970	mechanosensitive ion channel activity
DESTI_RS17465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESTI_RS17485	COG0701	Predicted permease
DESTI_RS17490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DESTI_RS17495	COG1121	(ABC) transporter
DESTI_RS17500	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
DESTI_RS17570	COG2205	protein histidine kinase activity
DESTI_RS17575	COG0745	RESPONSE REGULATOR receiver
DESTI_RS17595	COG0577	efflux transmembrane transporter activity
DESTI_RS17595	COG1136	(ABC) transporter
DESTI_RS17600	COG1136	(ABC) transporter
DESTI_RS17600	COG0577	efflux transmembrane transporter activity
DESTI_RS17620	COG0693	protein deglycase activity
DESTI_RS17625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DESTI_RS17630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DESTI_RS17635	COG0581	inorganic phosphate transmembrane transporter activity
DESTI_RS17640	COG0573	inorganic phosphate transmembrane transporter activity
DESTI_RS17645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DESTI_RS17650	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DESTI_RS17655	COG3920	Histidine kinase
DESTI_RS17685	COG2202	Pas domain
DESTI_RS17685	COG2205	protein histidine kinase activity
DESTI_RS17740	COG3437	response regulator, receiver
DESTI_RS17765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DESTI_RS17790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DESTI_RS17795	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DESTI_RS17805	COG0617	tRNA 3'-terminal CCA addition
DESTI_RS17805	COG0617	tRNA 3'-terminal CCA addition
DESTI_RS17825	COG2204	response regulator
DESTI_RS17830	COG2205	protein histidine kinase activity
DESTI_RS17855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DESTI_RS17870	COG0521	Mo-molybdopterin cofactor biosynthetic process
DESTI_RS17875	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DESTI_RS17890	COG4608	Belongs to the ABC transporter superfamily
DESTI_RS17915	COG1522	sequence-specific DNA binding
DESTI_RS17925	COG0004	ammonium transporteR
DESTI_RS17935	COG0004	ammonium transporteR
DESTI_RS17945	COG0174	glutamine synthetase
DESTI_RS17955	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DESTI_RS17955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DESTI_RS17960	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DESTI_RS17970	COG0367	asparagine synthase
DESTI_RS17975	COG0463	Glycosyl transferase, family 2
DESTI_RS18005	COG2003	Belongs to the UPF0758 family
DESTI_RS18010	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DESTI_RS18015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DESTI_RS18035	COG1489	DNA binding
DESTI_RS18040	COG0571	ribonuclease III activity
DESTI_RS18045	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DESTI_RS18055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DESTI_RS18060	COG0742	ribosomal rna small subunit methyltransferase
DESTI_RS18085	COG2226	methyltransferase
DESTI_RS18155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DESTI_RS18200	COG0463	Glycosyl transferase, family 2
DESTI_RS18200	COG1216	Glycosyl transferase, family 2
DESTI_RS18210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS18225	COG3875	lactate racemase activity
DESTI_RS18230	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS18230	COG1216	Glycosyl transferase, family 2
DESTI_RS18280	COG1024	Enoyl-CoA hydratase
DESTI_RS18300	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DESTI_RS18315	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DESTI_RS18315	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DESTI_RS18320	COG0525	valine-tRNA ligase activity
DESTI_RS18345	COG0352	thiamine-phosphate diphosphorylase activity
DESTI_RS18350	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DESTI_RS18355	COG0410	ABC transporter
DESTI_RS18375	COG1172	Belongs to the binding-protein-dependent transport system permease family
DESTI_RS18395	COG0535	radical SAM domain protein
DESTI_RS18410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DESTI_RS18415	COG0006	proline dipeptidase activity
DESTI_RS18425	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DESTI_RS18430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DESTI_RS18435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DESTI_RS18440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DESTI_RS18445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DESTI_RS18450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DESTI_RS18455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DESTI_RS18465	COG0772	Belongs to the SEDS family
DESTI_RS18470	COG0768	penicillin binding
DESTI_RS18480	COG1792	Involved in formation and maintenance of cell shape
DESTI_RS18490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DESTI_RS18495	COG1253	flavin adenine dinucleotide binding
DESTI_RS18505	COG0779	Required for maturation of 30S ribosomal subunits
DESTI_RS18510	COG0195	Participates in both transcription termination and antitermination
DESTI_RS18520	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DESTI_RS18530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DESTI_RS18535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DESTI_RS18555	COG0183	Belongs to the thiolase family
DESTI_RS18565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DESTI_RS18585	COG1215	transferase activity, transferring glycosyl groups
DESTI_RS18615	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DESTI_RS18620	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DESTI_RS18625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DESTI_RS18630	COG1522	sequence-specific DNA binding
DESTI_RS18645	COG1032	radical SAM domain protein
DESTI_RS18650	COG0330	HflC and HflK could
DESTI_RS18655	COG0330	HflC and HflK could
DESTI_RS18675	COG0114	fumarate hydratase activity
DESTI_RS18680	COG1013	pyruvate-flavodoxin oxidoreductase activity
DESTI_RS18685	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DESTI_RS18685	COG0674	pyruvate-flavodoxin oxidoreductase activity
DESTI_RS18725	COG2192	nodulation
DESTI_RS18735	COG0737	Belongs to the 5'-nucleotidase family
DESTI_RS18745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DESTI_RS18750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DESTI_RS18755	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DESTI_RS18760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DESTI_RS18765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DESTI_RS18770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DESTI_RS18785	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DESTI_RS18805	COG0135	phosphoribosylanthranilate isomerase activity
DESTI_RS18830	COG3956	TIGRFAM MazG family protein
DESTI_RS18840	COG1480	7TM receptor with intracellular HD hydrolase
DESTI_RS18845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DESTI_RS18880	COG0842	Transport permease protein
DESTI_RS18885	COG1131	(ABC) transporter
DESTI_RS18890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS18895	COG1309	transcriptional regulator
DESTI_RS18900	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS18930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DESTI_RS18940	COG0295	cytidine deaminase activity
DESTI_RS18960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DESTI_RS18970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DESTI_RS18985	COG0071	Belongs to the small heat shock protein (HSP20) family
DESTI_RS18990	COG0484	heat shock protein binding
DESTI_RS19000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DESTI_RS19020	COG1160	GTP binding
DESTI_RS19030	COG0501	Belongs to the peptidase M48B family
DESTI_RS19035	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DESTI_RS19045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DESTI_RS19060	COG0495	leucyl-tRNA aminoacylation
DESTI_RS19085	COG0039	L-malate dehydrogenase activity
DESTI_RS19095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESTI_RS19115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DESTI_RS19125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DESTI_RS19130	COG0072	phenylalanine-tRNA ligase activity
DESTI_RS19130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DESTI_RS19150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DESTI_RS19165	COG1233	COG1233 Phytoene dehydrogenase and related
DESTI_RS19175	COG0247	lactate metabolic process
DESTI_RS19175	COG2181	nitrate reductase activity
DESTI_RS19210	COG0436	Aminotransferase
DESTI_RS19225	COG2815	serine threonine protein kinase
DESTI_RS19225	COG0515	serine threonine protein kinase
DESTI_RS19240	COG0488	(ABC) transporter
DESTI_RS19245	COG0037	tRNA processing
DESTI_RS19255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DESTI_RS19255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DESTI_RS19260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DESTI_RS19275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESTI_RS19295	COG0564	pseudouridine synthase activity
DESTI_RS19300	COG0010	Belongs to the arginase family
DESTI_RS19305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESTI_RS19310	COG0194	GDP metabolic process
DESTI_RS19340	COG0509	glycine decarboxylation via glycine cleavage system
DESTI_RS19360	COG1366	Belongs to the anti-sigma-factor antagonist family
DESTI_RS19365	COG2208	phosphoserine phosphatase activity
DESTI_RS19365	COG2770	Histidine kinase
DESTI_RS19375	COG0515	serine threonine protein kinase
DESTI_RS19375	COG2815	serine threonine protein kinase
DESTI_RS19440	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DESTI_RS19445	COG0602	queuosine metabolic process
DESTI_RS19465	COG1597	lipid kinase activity
DESTI_RS19475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESTI_RS19480	COG0598	Magnesium transport protein CorA
DESTI_RS19490	COG2080	2 iron, 2 sulfur cluster binding
DESTI_RS19490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DESTI_RS19500	COG0517	IMP dehydrogenase activity
DESTI_RS19520	COG0018	arginyl-trna synthetase
DESTI_RS19545	COG0594	ribonuclease P activity
DESTI_RS19550	COG0706	membrane insertase activity
DESTI_RS19555	COG1847	R3H domain protein
DESTI_RS19560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DESTI_RS19565	COG4770	biotin carboxylase activity
DESTI_RS19570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DESTI_RS19595	COG1396	sequence-specific DNA binding
DESTI_RS19605	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DESTI_RS19605	COG0778	Nitroreductase
DESTI_RS19615	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DESTI_RS19620	COG2890	protein-(glutamine-N5) methyltransferase activity
DESTI_RS19640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DESTI_RS19645	COG1116	anion transmembrane transporter activity
DESTI_RS19660	COG2210	Belongs to the sulfur carrier protein TusA family
DESTI_RS19695	COG1566	PFAM secretion protein HlyD family protein
DESTI_RS19710	COG0039	L-malate dehydrogenase activity
DESTI_RS19720	COG0052	Belongs to the universal ribosomal protein uS2 family
DESTI_RS19725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DESTI_RS19730	COG0528	UMP kinase activity
DESTI_RS19735	COG0233	cytoplasmic translational termination
DESTI_RS19745	COG0575	Belongs to the CDS family
DESTI_RS19750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DESTI_RS19755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DESTI_RS19785	COG0752	glycyl-tRNA synthetase alpha subunit
DESTI_RS19810	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DESTI_RS19820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DESTI_RS19825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DESTI_RS19835	COG1597	lipid kinase activity
DESTI_RS19845	COG0693	protein deglycase activity
DESTI_RS19850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DESTI_RS19865	COG1381	Involved in DNA repair and RecF pathway recombination
DESTI_RS19885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DESTI_RS19895	COG0254	rRNA binding
DESTI_RS19900	COG3872	metal-dependent enzyme
DESTI_RS19905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DESTI_RS19915	COG0196	riboflavin kinase activity
DESTI_RS19960	COG2086	electron transfer activity
DESTI_RS19965	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DESTI_RS20030	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
DESTI_RS20050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DESTI_RS20070	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DESTI_RS20080	COG0045	succinate-CoA ligase (ADP-forming) activity
DESTI_RS20090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DESTI_RS20095	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DESTI_RS20095	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DESTI_RS20100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESTI_RS20115	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DESTI_RS20120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DESTI_RS20150	COG2046	Belongs to the sulfate adenylyltransferase family
DESTI_RS20160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DESTI_RS20165	COG1185	polyribonucleotide nucleotidyltransferase activity
DESTI_RS20170	COG0612	Peptidase, M16
DESTI_RS20195	COG0776	regulation of translation
DESTI_RS20200	COG0776	regulation of translation
DESTI_RS20220	COG3246	L-lysine catabolic process to acetate
DESTI_RS20260	COG1309	transcriptional regulator
DESTI_RS20265	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DESTI_RS20270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DESTI_RS20280	COG2264	protein methyltransferase activity
DESTI_RS20290	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DESTI_RS20295	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DESTI_RS20320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DESTI_RS20340	COG0297	glycogen (starch) synthase activity
DESTI_RS20340	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS20365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DESTI_RS20380	COG0298	carbon dioxide binding
DESTI_RS20390	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DESTI_RS20400	COG0512	Glutamine amidotransferase of anthranilate synthase
DESTI_RS20405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DESTI_RS20410	COG0134	indole-3-glycerol-phosphate synthase activity
DESTI_RS20415	COG0135	phosphoribosylanthranilate isomerase activity
DESTI_RS20420	COG0133	tryptophan synthase activity
DESTI_RS20425	COG0159	tryptophan synthase activity
DESTI_RS20435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DESTI_RS20485	COG0243	molybdopterin cofactor binding
DESTI_RS20505	COG0437	4 iron, 4 sulfur cluster binding
DESTI_RS20540	COG0071	Belongs to the small heat shock protein (HSP20) family
DESTI_RS20550	COG0242	peptide deformylase activity
DESTI_RS20555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DESTI_RS20565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DESTI_RS20565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DESTI_RS20575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DESTI_RS20580	COG0473	3-isopropylmalate dehydrogenase activity
DESTI_RS20585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DESTI_RS20610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DESTI_RS20635	COG0745	RESPONSE REGULATOR receiver
DESTI_RS20655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DESTI_RS20660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DESTI_RS20690	COG3769	mannosylglycerate metabolic process
DESTI_RS20695	COG1215	transferase activity, transferring glycosyl groups
DESTI_RS20700	COG0463	Glycosyl transferase, family 2
DESTI_RS20725	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DESTI_RS20730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DESTI_RS20735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DESTI_RS20745	COG1104	cysteine desulfurase activity
DESTI_RS20750	COG4953	penicillin-binding protein 1C
DESTI_RS20780	COG0805	protein transport
DESTI_RS20825	COG0671	phosphoesterase, PA-phosphatase related
DESTI_RS20875	COG5002	protein histidine kinase activity
DESTI_RS20885	COG1959	2 iron, 2 sulfur cluster binding
DESTI_RS20915	COG0306	phosphate transporter
DESTI_RS20920	COG0589	response to stress
DESTI_RS20925	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DESTI_RS20955	COG0583	DNA-binding transcription factor activity
DESTI_RS20970	COG3527	Alpha-acetolactate decarboxylase
DESTI_RS21040	COG0430	RNA-3'-phosphate cyclase activity
DESTI_RS21045	COG2135	peptidase activity
DESTI_RS21055	COG1215	transferase activity, transferring glycosyl groups
DESTI_RS21065	COG3191	aminopeptidase activity
DESTI_RS21070	COG1063	alcohol dehydrogenase
DESTI_RS21080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DESTI_RS21085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DESTI_RS21090	COG0538	isocitrate dehydrogenase activity
DESTI_RS21130	COG2048	Heterodisulfide reductase, subunit B
DESTI_RS21150	COG1233	COG1233 Phytoene dehydrogenase and related
DESTI_RS21205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DESTI_RS21210	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DESTI_RS21220	COG0735	belongs to the Fur family
DESTI_RS21225	COG1592	Rubrerythrin
DESTI_RS21230	COG2033	superoxide reductase activity
DESTI_RS21265	COG0426	domain, Protein
DESTI_RS21275	COG1271	oxidase subunit
DESTI_RS21280	COG1294	oxidase, subunit
DESTI_RS21285	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DESTI_RS21290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DESTI_RS21295	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DESTI_RS21310	COG2217	Heavy metal translocating P-type atpase
DESTI_RS21315	COG0827	DNA restriction-modification system
DESTI_RS21400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DESTI_RS21405	COG1121	(ABC) transporter
DESTI_RS21430	COG4251	negative regulation of phosphorylation
DESTI_RS21435	COG4251	negative regulation of phosphorylation
DESTI_RS21450	COG0724	RNA recognition motif
DESTI_RS21465	COG0730	response to heat
DESTI_RS21500	COG0411	ABC transporter
DESTI_RS21510	COG1022	Amp-dependent synthetase and ligase
DESTI_RS21515	COG2502	aspartate--ammonia ligase
DESTI_RS21520	COG5002	protein histidine kinase activity
DESTI_RS21525	COG0745	RESPONSE REGULATOR receiver
DESTI_RS21555	COG2204	response regulator
DESTI_RS21565	COG2204	response regulator
DESTI_RS21575	COG2204	response regulator
DESTI_RS21610	COG2204	response regulator
DESTI_RS21615	COG2268	Band 7 protein
DESTI_RS21645	COG0306	phosphate transporter
DESTI_RS21685	COG0574	Belongs to the PEP-utilizing enzyme family
DESTI_RS21685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DESTI_RS21695	COG1573	uracil-dna glycosylase
DESTI_RS21700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DESTI_RS21720	COG2188	Transcriptional regulator
DESTI_RS21745	COG3118	belongs to the thioredoxin family
DESTI_RS21755	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DESTI_RS21765	COG0471	metal ion transport
DESTI_RS21810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DESTI_RS21815	COG0280	phosphate acetyltransferase
DESTI_RS21815	COG0857	belongs to the CobB CobQ family
DESTI_RS21820	COG0427	acetyl-CoA hydrolase
DESTI_RS21845	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DESTI_RS21895	COG0556	nucleotide-excision repair
DESTI_RS21910	COG0824	Thioesterase
DESTI_RS21930	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DESTI_RS21940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DESTI_RS21945	COG0497	DNA recombination
DESTI_RS21975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DESTI_RS22010	COG1194	a g-specific adenine glycosylase
DESTI_RS22055	COG0745	RESPONSE REGULATOR receiver
DESTI_RS22060	COG5002	protein histidine kinase activity
DESTI_RS22070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DESTI_RS22110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DESTI_RS22135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DESTI_RS22150	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DESTI_RS22195	COG1136	(ABC) transporter
DESTI_RS22195	COG0577	efflux transmembrane transporter activity
DESTI_RS22200	COG0577	efflux transmembrane transporter activity
DESTI_RS22200	COG1136	(ABC) transporter
DESTI_RS22210	COG2217	Heavy metal translocating P-type atpase
DESTI_RS22250	COG1606	tRNA processing
DESTI_RS22265	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DESTI_RS22275	COG0037	tRNA processing
DESTI_RS22340	COG1024	Enoyl-CoA hydratase
DESTI_RS22390	COG1053	succinate dehydrogenase
DESTI_RS22400	COG0437	4 iron, 4 sulfur cluster binding
DESTI_RS22425	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DESTI_RS22445	COG1418	mRNA catabolic process
DESTI_RS22465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DESTI_RS22535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DESTI_RS22545	COG1203	CRISPR-associated helicase, Cas3
DESTI_RS22560	COG1857	crispr-associated protein
DESTI_RS22575	COG1518	maintenance of DNA repeat elements
DESTI_RS22580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DESTI_RS22600	COG1216	Glycosyl transferase, family 2
DESTI_RS22600	COG0463	Glycosyl transferase, family 2
DESTI_RS22645	COG0489	protein tyrosine kinase activity
DESTI_RS22690	COG3243	poly(R)-hydroxyalkanoic acid synthase
DESTI_RS22700	COG2030	dehydratase
DESTI_RS22720	COG0666	response to abiotic stimulus
DESTI_RS22725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DESTI_RS22725	COG0519	Catalyzes the synthesis of GMP from XMP
DESTI_RS22750	COG0484	heat shock protein binding
DESTI_RS22770	COG0004	ammonium transporteR
DESTI_RS22785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DESTI_RS22840	COG0724	RNA recognition motif
DESTI_RS22860	COG0482	sulfurtransferase activity
DESTI_RS22865	COG2078	PFAM AMMECR1 domain protein
DESTI_RS22870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DESTI_RS22875	COG0517	IMP dehydrogenase activity
DESTI_RS22875	COG0516	GMP reductase activity
DESTI_RS22880	COG0616	signal peptide processing
DESTI_RS22905	COG1131	(ABC) transporter
DESTI_RS22940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESTI_RS22960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DESTI_RS22985	COG0156	8-amino-7-oxononanoate synthase activity
DESTI_RS22990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DESTI_RS23025	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS23040	COG1028	Short-chain dehydrogenase reductase Sdr
DESTI_RS23060	COG0411	ABC transporter
DESTI_RS23070	COG0673	inositol 2-dehydrogenase activity
DESTI_RS23110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DESTI_RS23115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DESTI_RS23155	COG0776	regulation of translation
DESTI_RS23160	COG0776	regulation of translation
DESTI_RS23165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DESTI_RS23180	COG0151	Belongs to the GarS family
DESTI_RS23195	COG1136	(ABC) transporter
DESTI_RS23205	COG0612	Peptidase, M16
DESTI_RS23215	COG0398	Pfam SNARE associated Golgi protein
DESTI_RS23230	COG1250	3-hydroxyacyl-CoA dehydrogenase
DESTI_RS23255	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DESTI_RS23280	COG1923	regulation of RNA biosynthetic process
DESTI_RS23285	COG0708	Exodeoxyribonuclease III
DESTI_RS23295	COG0275	rRNA processing
DESTI_RS23310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DESTI_RS23315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DESTI_RS23320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DESTI_RS23330	COG0772	Belongs to the SEDS family
DESTI_RS23335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DESTI_RS23340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DESTI_RS23345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DESTI_RS23360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DESTI_RS23385	COG0003	Pfam Anion-transporting ATPase
DESTI_RS23390	COG0003	Pfam Anion-transporting ATPase
DESTI_RS23400	COG1966	Carbon starvation protein
DESTI_RS23410	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS23430	COG2076	Multidrug Resistance protein
DESTI_RS23450	COG1104	cysteine desulfurase activity
DESTI_RS23455	COG0822	iron-sulfur transferase activity
DESTI_RS23460	COG0446	pyridine nucleotide-disulphide oxidoreductase
DESTI_RS23485	COG0750	zinc metalloprotease
DESTI_RS23490	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DESTI_RS23515	COG0515	serine threonine protein kinase
DESTI_RS23515	COG2815	serine threonine protein kinase
DESTI_RS23520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DESTI_RS23525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DESTI_RS23525	COG0758	DNA mediated transformation
DESTI_RS23540	COG1007	ATP synthesis coupled electron transport
DESTI_RS23550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DESTI_RS23555	COG0713	ATP synthesis coupled electron transport
DESTI_RS23560	COG0839	Belongs to the complex I subunit 6 family
DESTI_RS23565	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESTI_RS23570	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DESTI_RS23580	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DESTI_RS23585	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DESTI_RS23590	COG0649	NAD binding
DESTI_RS23590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESTI_RS23595	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESTI_RS23600	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESTI_RS23640	COG5012	cobalamin binding
DESTI_RS23655	COG2223	nitrite transmembrane transporter activity
DESTI_RS23660	COG2188	Transcriptional regulator
DESTI_RS23665	COG5012	cobalamin binding
DESTI_RS23685	COG2855	membrane
DESTI_RS23690	COG2204	response regulator
DESTI_RS23710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DESTI_RS23715	COG1121	(ABC) transporter
DESTI_RS23770	COG2079	MmgE PrpD family protein
DESTI_RS23810	COG1127	ABC transporter
DESTI_RS23815	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DESTI_RS23845	COG1078	dGTPase activity
DESTI_RS23895	COG2201	protein-glutamate methylesterase activity
DESTI_RS23900	COG0835	chemotaxis
DESTI_RS23910	COG2201	protein-glutamate methylesterase activity
DESTI_RS23915	COG0840	transmembrane signaling receptor activity
DESTI_RS23925	COG1192	Involved in chromosome partitioning
DESTI_RS23930	COG2201	protein-glutamate methylesterase activity
DESTI_RS23935	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
DESTI_RS23940	COG1028	Short-chain dehydrogenase reductase Sdr
DESTI_RS23975	COG0604	alcohol dehydrogenase
DESTI_RS23995	COG0658	competence protein
DESTI_RS23995	COG2333	competence protein COMEC
DESTI_RS24025	COG0573	inorganic phosphate transmembrane transporter activity
DESTI_RS24030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DESTI_RS24060	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DESTI_RS24060	COG1672	PFAM Archaeal ATPase
DESTI_RS24070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DESTI_RS24080	COG1215	transferase activity, transferring glycosyl groups
DESTI_RS24090	COG2226	methyltransferase
DESTI_RS24100	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DESTI_RS24120	COG1774	PSP1 C-terminal conserved region
DESTI_RS24125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DESTI_RS24130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DESTI_RS24135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DESTI_RS24140	COG1862	Preprotein translocase
DESTI_RS24145	COG0343	queuine tRNA-ribosyltransferase activity
DESTI_RS24155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DESTI_RS24160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DESTI_RS24180	COG1266	CAAX protease self-immunity
DESTI_RS24200	COG2223	nitrite transmembrane transporter activity
DESTI_RS24220	COG0577	efflux transmembrane transporter activity
DESTI_RS24225	COG3596	GTP binding
DESTI_RS24235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DESTI_RS24235	COG0574	Belongs to the PEP-utilizing enzyme family
DESTI_RS24245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DESTI_RS24260	COG1192	Involved in chromosome partitioning
DESTI_RS24305	COG0028	Belongs to the TPP enzyme family
DESTI_RS24325	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS24330	COG2204	response regulator
DESTI_RS24335	COG4191	Histidine kinase
DESTI_RS24355	COG0646	methionine synthase
DESTI_RS24355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DESTI_RS24365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DESTI_RS24365	COG0425	Belongs to the sulfur carrier protein TusA family
DESTI_RS24385	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DESTI_RS24390	COG1122	ATPase activity
DESTI_RS24415	COG2721	sulfolactate sulfo-lyase activity
DESTI_RS24420	COG2721	sulfolactate sulfo-lyase activity
DESTI_RS24440	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DESTI_RS24485	COG2204	response regulator
DESTI_RS24495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESTI_RS24600	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DESTI_RS24600	COG1918	ferrous iron import across plasma membrane
DESTI_RS24665	COG2217	Heavy metal translocating P-type atpase
DESTI_RS24685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DESTI_RS24705	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DESTI_RS24715	COG2121	Domain of unknown function (DUF374)
DESTI_RS24770	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DESTI_RS24810	COG0442	prolyl-tRNA aminoacylation
DESTI_RS24870	COG1024	Enoyl-CoA hydratase
DESTI_RS24880	COG1902	pentaerythritol trinitrate reductase activity
DESTI_RS24880	COG0446	pyridine nucleotide-disulphide oxidoreductase
DESTI_RS24900	COG0138	bifunctional purine biosynthesis protein purh
DESTI_RS24940	COG2048	Heterodisulfide reductase, subunit B
DESTI_RS24960	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DESTI_RS24965	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DESTI_RS24970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DESTI_RS24980	COG0577	efflux transmembrane transporter activity
DESTI_RS24985	COG0321	lipoyl(octanoyl) transferase activity
DESTI_RS24990	COG0183	Belongs to the thiolase family
DESTI_RS25000	COG2340	Cysteine-rich secretory protein family
DESTI_RS25025	COG1832	CoA-binding protein
DESTI_RS25040	COG1477	protein flavinylation
DESTI_RS25050	COG0667	Aldo Keto reductase
DESTI_RS25055	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DESTI_RS25075	COG0724	RNA recognition motif
DESTI_RS25080	COG1032	radical SAM domain protein
DESTI_RS25085	COG3119	arylsulfatase activity
DESTI_RS25120	COG0745	RESPONSE REGULATOR receiver
DESTI_RS25125	COG5002	protein histidine kinase activity
DESTI_RS25130	COG0704	Plays a role in the regulation of phosphate uptake
DESTI_RS25145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DESTI_RS25155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DESTI_RS25160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DESTI_RS25225	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DESTI_RS25230	COG0285	dihydrofolate synthase activity
DESTI_RS25250	COG0318	PFAM AMP-dependent synthetase and ligase
DESTI_RS25260	COG0784	Response regulator, receiver
DESTI_RS25300	COG0697	spore germination
DESTI_RS25330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESTI_RS25410	COG1525	nuclease
DESTI_RS25495	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DESTI_RS25530	COG4771	TonB-dependent receptor
DESTI_RS25550	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DESTI_RS25555	COG4106	trans-aconitate 2-methyltransferase activity
DESTI_RS25560	COG1160	GTP binding
DESTI_RS25565	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DESTI_RS25570	COG1027	Aspartate ammonia-lyase
DESTI_RS25595	COG4624	Iron only hydrogenase large subunit, C-terminal domain
DESTI_RS25595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DESTI_RS25735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DESTI_RS25750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DESTI_RS25760	COG0446	pyridine nucleotide-disulphide oxidoreductase
DESTI_RS25765	COG1691	(AIR) carboxylase
DESTI_RS25770	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DESTI_RS25790	COG1733	regulation of RNA biosynthetic process
DESTI_RS25820	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DESTI_RS25825	COG0058	SHG alpha-glucan phosphorylase activity
DESTI_RS25830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DESTI_RS25830	COG4651	solute:proton antiporter activity
DESTI_RS25835	COG0861	Integral membrane protein TerC family
DESTI_RS25860	COG1598	PFAM Uncharacterised protein family UPF0150
DESTI_RS25965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS25970	COG1131	(ABC) transporter
DESTI_RS25975	COG1131	(ABC) transporter
DESTI_RS25980	COG0842	Transport permease protein
DESTI_RS25985	COG0842	Transport permease protein
DESTI_RS25990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESTI_RS25995	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DESTI_RS26025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DESTI_RS26030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DESTI_RS26040	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DESTI_RS26050	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DESTI_RS26055	COG0081	regulation of translation
DESTI_RS26060	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DESTI_RS26065	COG0222	ribosome binding
DESTI_RS26070	COG0085	RNA polymerase activity
DESTI_RS26075	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DESTI_RS26080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DESTI_RS26085	COG0049	tRNA binding
DESTI_RS26090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DESTI_RS26095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DESTI_RS26100	COG0051	transcription antitermination factor activity, RNA binding
DESTI_RS26105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DESTI_RS26110	COG0088	Forms part of the polypeptide exit tunnel
DESTI_RS26115	COG0089	rRNA binding
DESTI_RS26125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DESTI_RS26130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DESTI_RS26135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DESTI_RS26140	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DESTI_RS26150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DESTI_RS26160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DESTI_RS26165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DESTI_RS26170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DESTI_RS26175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DESTI_RS26180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DESTI_RS26190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DESTI_RS26195	COG1841	ribosomal large subunit assembly
DESTI_RS26200	COG0200	Binds to the 23S rRNA
DESTI_RS26205	COG0201	protein transport
DESTI_RS26210	COG0563	adenylate kinase activity
DESTI_RS26215	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DESTI_RS26220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DESTI_RS26225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DESTI_RS26230	COG0202	RNA polymerase activity
DESTI_RS26235	COG0203	ribosomal protein L17
DESTI_RS26240	COG1122	ATPase activity
DESTI_RS26275	COG0187	DNA topoisomerase II activity
DESTI_RS26280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DESTI_RS26305	COG0156	8-amino-7-oxononanoate synthase activity
DESTI_RS26365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DESTI_RS26370	COG3206	protein involved in exopolysaccharide biosynthesis
DESTI_RS26370	COG0489	protein tyrosine kinase activity
DESTI_RS26385	COG3852	Histidine kinase
DESTI_RS26390	COG2204	response regulator
DESTI_RS26400	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DESTI_RS26405	COG5002	protein histidine kinase activity
DESTI_RS26410	COG2204	response regulator
DESTI_RS26415	COG5557	Pfam Polysulphide reductase, NrfD
DESTI_RS26420	COG0437	4 iron, 4 sulfur cluster binding
DESTI_RS26420	COG3064	Membrane
DESTI_RS26430	COG0247	lactate metabolic process
DESTI_RS26435	COG2181	nitrate reductase activity
DESTI_RS26445	COG5002	protein histidine kinase activity
DESTI_RS26450	COG0784	Response regulator, receiver
DESTI_RS26480	COG2144	transferase activity, transferring acyl groups
DESTI_RS26495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DESTI_RS26500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DESTI_RS26510	COG2181	nitrate reductase activity
DESTI_RS26510	COG0247	lactate metabolic process
DESTI_RS26555	COG1012	belongs to the aldehyde dehydrogenase family
DESTI_RS26565	COG0247	lactate metabolic process
DESTI_RS26565	COG2181	nitrate reductase activity
DESTI_RS26570	COG2223	nitrite transmembrane transporter activity
DESTI_RS26595	COG2080	2 iron, 2 sulfur cluster binding
DESTI_RS26600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DESTI_RS26605	COG0683	leucine binding
DESTI_RS26610	COG0411	ABC transporter
DESTI_RS26640	COG2084	Dehydrogenase
DESTI_RS26655	COG1119	ATPase activity
DESTI_RS26710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DESTI_RS26715	COG0798	PFAM Bile acid sodium symporter
DESTI_RS26760	COG0640	Transcriptional regulator
DESTI_RS26835	COG1309	transcriptional regulator
DESTI_RS26840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DESTI_RS26845	COG2030	dehydratase
DESTI_RS26850	COG3246	L-lysine catabolic process to acetate
DESTI_RS26855	COG2072	flavoprotein involved in K transport
DESTI_RS26865	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS26870	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS26890	COG0183	Belongs to the thiolase family
DESTI_RS26900	COG0183	Belongs to the thiolase family
DESTI_RS26910	COG1250	3-hydroxyacyl-CoA dehydrogenase
DESTI_RS26915	COG1024	Enoyl-CoA hydratase
DESTI_RS26960	COG1595	DNA-templated transcription, initiation
DESTI_RS26965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DESTI_RS26970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DESTI_RS27015	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
DESTI_RS27045	COG1136	(ABC) transporter
DESTI_RS27065	COG4771	TonB-dependent receptor
DESTI_RS27075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS27085	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
DESTI_RS27085	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
DESTI_RS27090	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
DESTI_RS27110	COG1120	ATPase activity
DESTI_RS27115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DESTI_RS27120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DESTI_RS27125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DESTI_RS27145	COG0577	efflux transmembrane transporter activity
DESTI_RS27145	COG1136	(ABC) transporter
DESTI_RS27165	COG1960	acyl-CoA dehydrogenase activity
DESTI_RS27175	COG0789	Transcriptional regulator
DESTI_RS27200	COG0517	IMP dehydrogenase activity
DESTI_RS27205	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
DESTI_RS27210	COG0347	Belongs to the P(II) protein family
DESTI_RS27245	COG0535	radical SAM domain protein
DESTI_RS27245	COG1433	Dinitrogenase iron-molybdenum cofactor
DESTI_RS27275	COG2223	nitrite transmembrane transporter activity
DESTI_RS27310	COG1408	metallophosphoesterase
DESTI_RS27325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESTI_RS27330	COG1136	(ABC) transporter
DESTI_RS27335	COG0577	efflux transmembrane transporter activity
DESTI_RS27335	COG1136	(ABC) transporter
DESTI_RS27340	COG4591	ABC-type transport system involved in lipoprotein release permease component
DESTI_RS27340	COG1136	(ABC) transporter
DESTI_RS27350	COG2264	protein methyltransferase activity
DESTI_RS27360	COG0726	polysaccharide deacetylase
DESTI_RS27375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DESTI_RS27380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DESTI_RS27385	COG0601	transmembrane transport
DESTI_RS27400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DESTI_RS27415	COG0583	DNA-binding transcription factor activity
DESTI_RS27420	COG2031	fatty acid transporter
DESTI_RS27445	COG2379	hydroxypyruvate reductase
DESTI_RS27460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DESTI_RS27465	COG0504	CTP synthase activity
DESTI_RS27470	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DESTI_RS27485	COG1137	ATPase activity
DESTI_RS27490	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DESTI_RS27500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DESTI_RS27505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DESTI_RS27505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DESTI_RS27525	COG2205	protein histidine kinase activity
DESTI_RS27525	COG0784	Response regulator, receiver
DESTI_RS27530	COG0683	leucine binding
DESTI_RS27555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DESTI_RS27580	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS27585	COG0688	phosphatidylethanolamine metabolic process
DESTI_RS27625	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DESTI_RS27650	COG0427	acetyl-CoA hydrolase
DESTI_RS27655	COG0280	phosphate acetyltransferase
DESTI_RS27655	COG0857	belongs to the CobB CobQ family
DESTI_RS27660	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DESTI_RS27710	COG0746	molybdenum cofactor guanylyltransferase activity
DESTI_RS27720	COG0357	Ribosomal RNA small subunit methyltransferase G
DESTI_RS27725	COG1324	tolerance protein
DESTI_RS27730	COG1329	Transcriptional regulator
DESTI_RS27735	COG4956	integral membrane protein (PIN domain superfamily)
DESTI_RS27765	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DESTI_RS27780	COG1797	cobyrinic acid a,c-diamide synthase activity
DESTI_RS27795	COG0310	cobalt ion transport
DESTI_RS27810	COG1122	ATPase activity
DESTI_RS27815	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DESTI_RS27865	COG1309	transcriptional regulator
DESTI_RS27870	COG0626	cystathionine gamma-synthase activity
DESTI_RS27915	COG0322	excinuclease ABC activity
DESTI_RS27925	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DESTI_RS27930	COG1144	Oxidoreductase
DESTI_RS27935	COG0674	pyruvate-flavodoxin oxidoreductase activity
DESTI_RS27940	COG1013	pyruvate-flavodoxin oxidoreductase activity
DESTI_RS27945	COG0747	negative chemotaxis
DESTI_RS27950	COG0601	transmembrane transport
DESTI_RS27955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DESTI_RS27960	COG0444	Belongs to the ABC transporter superfamily
DESTI_RS27965	COG4608	Belongs to the ABC transporter superfamily
DESTI_RS27970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DESTI_RS27975	COG1183	phosphatidylcholine synthase activity
DESTI_RS27985	COG0577	efflux transmembrane transporter activity
DESTI_RS27990	COG1136	(ABC) transporter
DESTI_RS28000	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DESTI_RS28010	COG1192	Involved in chromosome partitioning
DESTI_RS28015	COG1475	DNA binding
DESTI_RS28155	COG0277	FAD linked oxidase domain protein
DESTI_RS28170	COG3852	Histidine kinase
DESTI_RS28180	COG4942	peptidase
DESTI_RS28190	COG0745	RESPONSE REGULATOR receiver
DESTI_RS28205	COG4251	negative regulation of phosphorylation
DESTI_RS28230	COG4251	negative regulation of phosphorylation
DESTI_RS28235	COG2204	response regulator
DESTI_RS28240	COG2204	response regulator
DESTI_RS28265	COG0840	transmembrane signaling receptor activity
DESTI_RS28270	COG0739	heme binding
DESTI_RS28285	COG2204	response regulator
DESTI_RS28290	COG2204	response regulator
DESTI_RS28300	COG4251	negative regulation of phosphorylation
DESTI_RS28305	COG2204	response regulator
DESTI_RS28310	COG3437	response regulator, receiver
DESTI_RS28310	COG3850	Histidine kinase
DESTI_RS28310	COG4999	Histidine kinase
DESTI_RS28310	COG2205	protein histidine kinase activity
DESTI_RS28320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DESTI_RS28355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DESTI_RS28375	COG0095	Lipoate-protein ligase
DESTI_RS28385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DESTI_RS28390	COG1657	PFAM Prenyltransferase squalene oxidase
DESTI_RS28405	COG4251	negative regulation of phosphorylation
DESTI_RS28415	COG4251	negative regulation of phosphorylation
DESTI_RS28420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DESTI_RS28435	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS28460	COG1309	transcriptional regulator
DESTI_RS28470	COG4251	negative regulation of phosphorylation
DESTI_RS28480	COG4251	negative regulation of phosphorylation
DESTI_RS28485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DESTI_RS28500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESTI_RS28510	COG0360	Binds together with S18 to 16S ribosomal RNA
DESTI_RS28515	COG0723	plastoquinol--plastocyanin reductase activity
DESTI_RS28530	COG3063	Type IV pilus biogenesis stability protein PilW
DESTI_RS28565	COG4251	negative regulation of phosphorylation
DESTI_RS28570	COG1309	transcriptional regulator
DESTI_RS28575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESTI_RS28585	COG1024	Enoyl-CoA hydratase
DESTI_RS28590	COG0297	glycogen (starch) synthase activity
DESTI_RS28600	COG4251	negative regulation of phosphorylation
DESTI_RS28605	COG0739	heme binding
DESTI_RS28605	COG0741	lytic transglycosylase activity
DESTI_RS28605	COG1196	nuclear chromosome segregation
DESTI_RS28610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DESTI_RS28635	COG4999	Histidine kinase
DESTI_RS28635	COG3437	response regulator, receiver
DESTI_RS28635	COG2205	protein histidine kinase activity
DESTI_RS28635	COG3850	Histidine kinase
DESTI_RS28660	COG2204	response regulator
DESTI_RS28660	COG2204	response regulator
DESTI_RS28665	COG2205	protein histidine kinase activity
DESTI_RS28665	COG2202	Pas domain
DESTI_RS28670	COG1309	transcriptional regulator
DESTI_RS28700	COG2204	response regulator
DESTI_RS28710	COG2204	response regulator
DESTI_RS28715	COG3852	Histidine kinase
DESTI_RS28720	COG4251	negative regulation of phosphorylation
DESTI_RS28755	COG2204	response regulator
DESTI_RS28775	COG1595	DNA-templated transcription, initiation
DESTI_RS28785	COG0420	3'-5' exonuclease activity
DESTI_RS28790	COG3437	response regulator, receiver
DESTI_RS28805	COG1882	Formate acetyltransferase
DESTI_RS28815	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DESTI_RS28830	COG0668	transmembrane transport
DESTI_RS28835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DESTI_RS28865	COG3437	response regulator, receiver
DESTI_RS28865	COG2770	Histidine kinase
DESTI_RS28870	COG1556	Lactate utilization protein
DESTI_RS28875	COG4251	negative regulation of phosphorylation
DESTI_RS28895	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DESTI_RS28900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DESTI_RS28900	COG0519	Catalyzes the synthesis of GMP from XMP
DESTI_RS28920	COG0519	Catalyzes the synthesis of GMP from XMP
DESTI_RS28960	COG2204	response regulator
DESTI_RS28975	COG0438	transferase activity, transferring glycosyl groups
DESTI_RS28985	COG4251	negative regulation of phosphorylation
DESTI_RS28990	COG4251	negative regulation of phosphorylation
DESTI_RS28995	COG0793	Belongs to the peptidase S41A family
DESTI_RS29000	COG3604	Transcriptional regulator
DESTI_RS29010	COG2186	Transcriptional regulator
DESTI_RS29050	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESTI_RS29070	COG4251	negative regulation of phosphorylation
DESTI_RS29075	COG2204	response regulator
DESTI_RS29080	COG4251	negative regulation of phosphorylation
DESTI_RS29090	COG2204	response regulator
DESTI_RS29105	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DESTI_RS29110	COG1216	Glycosyl transferase, family 2
DESTI_RS29120	COG2226	methyltransferase
DESTI_RS29145	COG2815	serine threonine protein kinase
DESTI_RS29145	COG0515	serine threonine protein kinase
DESTI_RS29150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DESTI_RS29170	COG2204	response regulator
DESTI_RS29175	COG2131	deaminase
DESTI_RS29205	COG2204	response regulator
DESTI_RS29225	COG0840	transmembrane signaling receptor activity
DESTI_RS29240	COG2264	protein methyltransferase activity
DESTI_RS29265	COG2204	response regulator
DESTI_RS29325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DESTI_RS29350	COG0726	polysaccharide deacetylase
DESTI_RS29360	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DESTI_RS29365	COG1214	PFAM Peptidase M22, glycoprotease
DESTI_RS29385	COG0741	lytic transglycosylase activity
DESTI_RS29385	COG0739	heme binding
DESTI_RS29385	COG1196	nuclear chromosome segregation
DESTI_RS29395	COG2198	Histidine kinase
DESTI_RS29395	COG0784	Response regulator, receiver
DESTI_RS29395	COG0643	Histidine kinase
DESTI_RS29415	COG2226	methyltransferase
DESTI_RS29470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DESTI_RS29475	COG4251	negative regulation of phosphorylation
DESTI_RS29480	COG4251	negative regulation of phosphorylation
DESTI_RS29505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DESTI_RS29510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DESTI_RS29530	COG2188	Transcriptional regulator
DESTI_RS29535	COG3118	belongs to the thioredoxin family
DESTI_RS29545	COG0811	peptide transport
DESTI_RS29550	COG0811	peptide transport
DESTI_RS29555	COG0582	viral genome integration into host DNA
DESTI_RS29565	COG3604	Transcriptional regulator
DESTI_RS29580	COG0745	RESPONSE REGULATOR receiver
DESTI_RS29585	COG2204	response regulator