locus-tag	class	description
FCL45_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FCL45_RS00015	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FCL45_RS00025	COG1011	Hydrolase
FCL45_RS00030	COG0584	glycerophosphoryl diester phosphodiesterase
FCL45_RS00035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FCL45_RS00045	COG4770	biotin carboxylase activity
FCL45_RS00080	COG0318	PFAM AMP-dependent synthetase and ligase
FCL45_RS00085	COG2270	Major facilitator Superfamily
FCL45_RS00095	COG0436	Aminotransferase
FCL45_RS00115	COG2186	Transcriptional regulator
FCL45_RS00120	COG0702	epimerase
FCL45_RS00125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL45_RS00130	COG2814	Major facilitator Superfamily
FCL45_RS00135	COG3875	lactate racemase activity
FCL45_RS00140	COG0429	hydrolase of the alpha beta-hydrolase fold
FCL45_RS00155	COG1473	amidohydrolase
FCL45_RS00190	COG3604	Transcriptional regulator
FCL45_RS00210	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FCL45_RS00220	COG1027	Aspartate ammonia-lyase
FCL45_RS00225	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FCL45_RS00235	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FCL45_RS00240	COG0321	lipoyl(octanoyl) transferase activity
FCL45_RS00245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FCL45_RS00250	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FCL45_RS00255	COG0509	glycine decarboxylation via glycine cleavage system
FCL45_RS00260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FCL45_RS00275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FCL45_RS00280	COG4136	ATPase activity
FCL45_RS00285	COG4135	transport system, permease component
FCL45_RS00290	COG4134	Bacterial extracellular solute-binding protein
FCL45_RS00295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FCL45_RS00305	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FCL45_RS00305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FCL45_RS00315	COG0745	RESPONSE REGULATOR receiver
FCL45_RS00320	COG2205	protein histidine kinase activity
FCL45_RS00370	COG1846	Transcriptional regulator
FCL45_RS00380	COG2204	response regulator
FCL45_RS00395	COG1490	D-aminoacyl-tRNA deacylase activity
FCL45_RS00430	COG4191	Histidine kinase
FCL45_RS00440	COG2358	TRAP transporter, solute receptor (TAXI family
FCL45_RS00450	COG0277	FAD linked oxidase domain protein
FCL45_RS00470	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FCL45_RS00475	COG2894	cell division
FCL45_RS00480	COG0850	regulation of cytokinetic process
FCL45_RS00490	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FCL45_RS00505	COG1126	abc transporter atp-binding protein
FCL45_RS00510	COG0765	amino acid transport
FCL45_RS00515	COG4597	amino acid ABC transporter
FCL45_RS00520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL45_RS00525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FCL45_RS00530	COG4948	Mandelate Racemase Muconate Lactonizing
FCL45_RS00540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FCL45_RS00540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FCL45_RS00550	COG0006	proline dipeptidase activity
FCL45_RS00570	COG0617	tRNA 3'-terminal CCA addition
FCL45_RS00570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FCL45_RS00570	COG3620	sequence-specific DNA binding
FCL45_RS00585	COG1053	succinate dehydrogenase
FCL45_RS00610	COG0492	ferredoxin-NADP+ reductase activity
FCL45_RS00615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FCL45_RS00620	COG0483	inositol monophosphate 1-phosphatase activity
FCL45_RS00625	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FCL45_RS00650	COG1131	(ABC) transporter
FCL45_RS00660	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FCL45_RS00665	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FCL45_RS00735	COG1733	regulation of RNA biosynthetic process
FCL45_RS00745	COG3360	Dodecin
FCL45_RS00780	COG2186	Transcriptional regulator
FCL45_RS00790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FCL45_RS00795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FCL45_RS00800	COG1607	acyl-coa hydrolase
FCL45_RS00805	COG1119	ATPase activity
FCL45_RS00815	COG1794	racemase activity, acting on amino acids and derivatives
FCL45_RS00820	COG0656	L-ascorbic acid biosynthetic process
FCL45_RS00830	COG2878	Part of a membrane complex involved in electron transport
FCL45_RS00830	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
FCL45_RS00835	COG4657	Part of a membrane complex involved in electron transport
FCL45_RS00840	COG4660	Part of a membrane complex involved in electron transport
FCL45_RS00845	COG4659	FMN binding
FCL45_RS00850	COG4658	electron transport chain
FCL45_RS00855	COG4656	Part of a membrane complex involved in electron transport
FCL45_RS00860	COG0167	dihydroorotate dehydrogenase activity
FCL45_RS00875	COG1643	Atp-dependent helicase
FCL45_RS00930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FCL45_RS00945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FCL45_RS00950	COG0124	histidyl-tRNA synthetase
FCL45_RS00955	COG2070	2-Nitropropane dioxygenase
FCL45_RS00960	COG0617	tRNA 3'-terminal CCA addition
FCL45_RS00965	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FCL45_RS00970	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FCL45_RS00975	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
FCL45_RS00980	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FCL45_RS00990	COG0409	Hydrogenase expression formation protein
FCL45_RS01020	COG0181	hydroxymethylbilane synthase activity
FCL45_RS01065	COG0004	ammonium transporteR
FCL45_RS01075	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
FCL45_RS01085	COG0347	Belongs to the P(II) protein family
FCL45_RS01100	COG1433	Dinitrogenase iron-molybdenum cofactor
FCL45_RS01100	COG0535	radical SAM domain protein
FCL45_RS01125	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FCL45_RS01145	COG0730	response to heat
FCL45_RS01155	COG0310	cobalt ion transport
FCL45_RS01160	COG0310	cobalt ion transport
FCL45_RS01175	COG1122	ATPase activity
FCL45_RS01180	COG3267	Type II secretory pathway component ExeA
FCL45_RS01180	COG3409	Peptidoglycan-binding domain 1 protein
FCL45_RS01195	COG0535	radical SAM domain protein
FCL45_RS01195	COG1433	Dinitrogenase iron-molybdenum cofactor
FCL45_RS01210	COG0427	acetyl-CoA hydrolase
FCL45_RS01215	COG0280	phosphate acetyltransferase
FCL45_RS01215	COG0857	belongs to the CobB CobQ family
FCL45_RS01225	COG2719	SpoVR family
FCL45_RS01245	COG3681	Belongs to the UPF0597 family
FCL45_RS01250	COG0047	phosphoribosylformylglycinamidine synthase activity
FCL45_RS01250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FCL45_RS01275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FCL45_RS01280	COG0798	PFAM Bile acid sodium symporter
FCL45_RS01295	COG1739	Uncharacterized protein family UPF0029
FCL45_RS01320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FCL45_RS01365	COG2205	protein histidine kinase activity
FCL45_RS01365	COG2202	Pas domain
FCL45_RS01395	COG2193	ferroxidase activity
FCL45_RS01405	COG1053	succinate dehydrogenase
FCL45_RS01410	COG1053	succinate dehydrogenase
FCL45_RS01420	COG3385	transposase activity
FCL45_RS01435	COG0784	Response regulator, receiver
FCL45_RS01435	COG2205	protein histidine kinase activity
FCL45_RS01440	COG0443	Heat shock 70 kDa protein
FCL45_RS01460	COG0786	glutamate:sodium symporter activity
FCL45_RS01470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FCL45_RS01480	COG0045	succinate-CoA ligase (ADP-forming) activity
FCL45_RS01480	COG1042	CoA-binding domain protein
FCL45_RS01480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FCL45_RS01510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FCL45_RS01520	COG1053	succinate dehydrogenase
FCL45_RS01525	COG3604	Transcriptional regulator
FCL45_RS01535	COG3829	transcription factor binding
FCL45_RS01535	COG3290	protein histidine kinase activity
FCL45_RS01585	COG0784	Response regulator, receiver
FCL45_RS01585	COG2205	protein histidine kinase activity
FCL45_RS01630	COG1305	Transglutaminase-like
FCL45_RS01640	COG0714	Associated with various cellular activities
FCL45_RS01660	COG1509	lysine 2,3-aminomutase activity
FCL45_RS01665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FCL45_RS01670	COG1335	isochorismatase
FCL45_RS01675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FCL45_RS01685	COG0778	Nitroreductase
FCL45_RS01690	COG0463	Glycosyl transferase, family 2
FCL45_RS01700	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FCL45_RS01705	COG0438	transferase activity, transferring glycosyl groups
FCL45_RS01710	COG1294	oxidase, subunit
FCL45_RS01735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FCL45_RS01770	COG0438	transferase activity, transferring glycosyl groups
FCL45_RS01780	COG2204	response regulator
FCL45_RS01785	COG1556	Lactate utilization protein
FCL45_RS01790	COG1139	Iron-sulfur cluster binding protein
FCL45_RS01800	COG0477	Major facilitator Superfamily
FCL45_RS01820	COG2080	2 iron, 2 sulfur cluster binding
FCL45_RS01825	COG2080	2 iron, 2 sulfur cluster binding
FCL45_RS01825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FCL45_RS01830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FCL45_RS01835	COG2068	MobA-Related Protein
FCL45_RS01840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FCL45_RS01840	COG3608	succinylglutamate desuccinylase aspartoacylase
FCL45_RS01845	COG3608	succinylglutamate desuccinylase aspartoacylase
FCL45_RS01845	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FCL45_RS01855	COG0012	GTP binding
FCL45_RS01860	COG0501	Belongs to the peptidase M48B family
FCL45_RS01880	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FCL45_RS01895	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FCL45_RS01905	COG0437	4 iron, 4 sulfur cluster binding
FCL45_RS01915	COG0243	molybdopterin cofactor binding
FCL45_RS01925	COG2084	Dehydrogenase
FCL45_RS01935	COG1272	protein, Hemolysin III
FCL45_RS01940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FCL45_RS01945	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FCL45_RS01950	COG2995	paraquat-inducible protein a
FCL45_RS01955	COG3008	intermembrane lipid transfer
FCL45_RS01960	COG0589	response to stress
FCL45_RS01965	COG4302	ethanolamine ammonia-lyase activity
FCL45_RS01970	COG4303	Ethanolamine ammonia lyase large subunit
FCL45_RS01990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FCL45_RS01995	COG0527	aspartate kinase activity
FCL45_RS02010	COG4372	Transposase
FCL45_RS02065	COG1216	Glycosyl transferase, family 2
FCL45_RS02065	COG1442	glycosyl transferase family 8
FCL45_RS02075	COG3385	transposase activity
FCL45_RS02080	COG1442	glycosyl transferase family 8
FCL45_RS02135	COG0826	peptidase U32
FCL45_RS02155	COG0183	Belongs to the thiolase family
FCL45_RS02185	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FCL45_RS02190	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FCL45_RS02200	COG1278	Cold shock
FCL45_RS02210	COG0440	acetolactate synthase activity
FCL45_RS02215	COG0028	Belongs to the TPP enzyme family
FCL45_RS02220	COG1454	alcohol dehydrogenase
FCL45_RS02225	COG0784	Response regulator, receiver
FCL45_RS02225	COG2205	protein histidine kinase activity
FCL45_RS02235	COG0351	phosphomethylpyrimidine kinase
FCL45_RS02260	COG1448	Aminotransferase
FCL45_RS02270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FCL45_RS02275	COG0280	phosphate acetyltransferase
FCL45_RS02275	COG0857	belongs to the CobB CobQ family
FCL45_RS02280	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FCL45_RS02285	COG4822	anaerobic cobalamin biosynthetic process
FCL45_RS02295	COG3273	potassium ion transport
FCL45_RS02295	COG0471	metal ion transport
FCL45_RS02305	COG0519	Catalyzes the synthesis of GMP from XMP
FCL45_RS02310	COG3259	Nickel-dependent hydrogenase
FCL45_RS02315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL45_RS02330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FCL45_RS02335	COG0601	transmembrane transport
FCL45_RS02350	COG1773	rubredoxin
FCL45_RS02355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FCL45_RS02395	COG0589	response to stress
FCL45_RS02400	COG2153	protein acetylation
FCL45_RS02425	COG2239	Acts as a magnesium transporter
FCL45_RS02435	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FCL45_RS02445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FCL45_RS02450	COG0569	domain protein
FCL45_RS02455	COG0582	viral genome integration into host DNA
FCL45_RS02515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FCL45_RS02610	COG1280	lysine exporter protein (LysE YggA)
FCL45_RS02620	COG3279	Response regulator of the LytR AlgR family
FCL45_RS02625	COG3275	phosphorelay sensor kinase activity
FCL45_RS02630	COG1966	Carbon starvation protein
FCL45_RS02655	COG0251	oxidation-reduction process
FCL45_RS02665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FCL45_RS02670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS02700	COG0284	orotidine-5'-phosphate decarboxylase activity
FCL45_RS02715	COG2304	oxidoreductase activity
FCL45_RS02730	COG0511	ligase activity, forming carbon-carbon bonds
FCL45_RS02735	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FCL45_RS02740	COG0489	protein tyrosine kinase activity
FCL45_RS02745	COG2920	part of a sulfur-relay system
FCL45_RS02750	COG2226	methyltransferase
FCL45_RS02770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FCL45_RS02775	COG0686	Belongs to the AlaDH PNT family
FCL45_RS02795	COG3829	transcription factor binding
FCL45_RS02795	COG3290	protein histidine kinase activity
FCL45_RS02800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FCL45_RS02815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS02840	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FCL45_RS02845	COG1166	arginine decarboxylase activity
FCL45_RS02860	COG0010	Belongs to the arginase family
FCL45_RS02895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FCL45_RS02895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FCL45_RS02900	COG0504	CTP synthase activity
FCL45_RS02905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FCL45_RS02920	COG1720	tRNA m6t6A37 methyltransferase activity
FCL45_RS02925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FCL45_RS02945	COG2078	PFAM AMMECR1 domain protein
FCL45_RS02950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FCL45_RS02970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FCL45_RS02970	COG0116	Belongs to the methyltransferase superfamily
FCL45_RS02980	COG2885	chlorophyll binding
FCL45_RS02985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FCL45_RS02990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FCL45_RS02995	COG0154	amidase activity
FCL45_RS03000	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FCL45_RS03010	COG2391	methyltransferase activity
FCL45_RS03015	COG0425	Belongs to the sulfur carrier protein TusA family
FCL45_RS03035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FCL45_RS03040	COG0592	DNA-directed DNA polymerase activity
FCL45_RS03045	COG0187	DNA topoisomerase II activity
FCL45_RS03050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FCL45_RS03055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FCL45_RS03060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FCL45_RS03065	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FCL45_RS03090	COG1475	DNA binding
FCL45_RS03095	COG1192	Involved in chromosome partitioning
FCL45_RS03140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FCL45_RS03145	COG2003	Belongs to the UPF0758 family
FCL45_RS03150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FCL45_RS03155	COG2954	triphosphatase activity
FCL45_RS03165	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FCL45_RS03180	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FCL45_RS03190	COG2264	protein methyltransferase activity
FCL45_RS03200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FCL45_RS03225	COG2304	oxidoreductase activity
FCL45_RS03240	COG0714	Associated with various cellular activities
FCL45_RS03245	COG0546	phosphoglycolate phosphatase activity
FCL45_RS03270	COG4191	Histidine kinase
FCL45_RS03275	COG0745	RESPONSE REGULATOR receiver
FCL45_RS03290	COG1215	transferase activity, transferring glycosyl groups
FCL45_RS03295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FCL45_RS03300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FCL45_RS03330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FCL45_RS03335	COG1137	ATPase activity
FCL45_RS03345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FCL45_RS03350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FCL45_RS03355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FCL45_RS03360	COG0137	argininosuccinate synthase activity
FCL45_RS03365	COG0165	Argininosuccinate lyase
FCL45_RS03375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FCL45_RS03380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FCL45_RS03385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FCL45_RS03400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FCL45_RS03405	COG0741	lytic transglycosylase activity
FCL45_RS03410	COG0659	secondary active sulfate transmembrane transporter activity
FCL45_RS03420	COG4974	Belongs to the 'phage' integrase family
FCL45_RS03435	COG0537	adenosine 5'-monophosphoramidase activity
FCL45_RS03505	COG2433	Pfam Transposase IS66
FCL45_RS03545	COG3437	response regulator, receiver
FCL45_RS03545	COG0784	Response regulator, receiver
FCL45_RS03555	COG2040	homocysteine
FCL45_RS03565	COG1151	hydroxylamine reductase activity
FCL45_RS03570	COG0583	DNA-binding transcription factor activity
FCL45_RS03585	COG3852	Histidine kinase
FCL45_RS03590	COG2204	response regulator
FCL45_RS03595	COG2204	response regulator
FCL45_RS03645	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FCL45_RS03650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL45_RS03680	COG1960	acyl-CoA dehydrogenase activity
FCL45_RS03700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FCL45_RS03745	COG0745	RESPONSE REGULATOR receiver
FCL45_RS03750	COG2205	protein histidine kinase activity
FCL45_RS03780	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FCL45_RS03815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FCL45_RS03815	COG0546	phosphoglycolate phosphatase activity
FCL45_RS03820	COG1024	Enoyl-CoA hydratase
FCL45_RS03830	COG0437	4 iron, 4 sulfur cluster binding
FCL45_RS03835	COG0243	molybdopterin cofactor binding
FCL45_RS03845	COG2197	response regulator
FCL45_RS03850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FCL45_RS03855	COG0589	response to stress
FCL45_RS03895	COG3119	arylsulfatase activity
FCL45_RS03895	COG3408	Glycogen debranching enzyme
FCL45_RS03920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FCL45_RS03925	COG1793	dna ligase
FCL45_RS03950	COG2207	Transcriptional regulator
FCL45_RS03965	COG1136	(ABC) transporter
FCL45_RS03965	COG0577	efflux transmembrane transporter activity
FCL45_RS03990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FCL45_RS04000	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FCL45_RS04005	COG2703	oxygen carrier activity
FCL45_RS04040	COG2267	carboxylic ester hydrolase activity
FCL45_RS04060	COG1525	nuclease
FCL45_RS04065	COG1834	amidinotransferase
FCL45_RS04070	COG1181	Belongs to the D-alanine--D-alanine ligase family
FCL45_RS04075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FCL45_RS04075	COG0519	Catalyzes the synthesis of GMP from XMP
FCL45_RS04080	COG2723	6-phospho-beta-galactosidase activity
FCL45_RS04160	COG2208	phosphoserine phosphatase activity
FCL45_RS04165	COG1132	(ABC) transporter
FCL45_RS04165	COG1132	(ABC) transporter
FCL45_RS04180	COG1366	Belongs to the anti-sigma-factor antagonist family
FCL45_RS04200	COG3706	GGDEF domain
FCL45_RS04205	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FCL45_RS04210	COG2195	Cleaves the N-terminal amino acid of tripeptides
FCL45_RS04215	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FCL45_RS04215	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FCL45_RS04230	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FCL45_RS04240	COG0501	Belongs to the peptidase M48B family
FCL45_RS04245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FCL45_RS04250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FCL45_RS04255	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FCL45_RS04265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FCL45_RS04275	COG0247	lactate metabolic process
FCL45_RS04285	COG0149	triose-phosphate isomerase activity
FCL45_RS04285	COG0126	phosphoglycerate kinase activity
FCL45_RS04290	COG0126	phosphoglycerate kinase activity
FCL45_RS04295	COG0148	phosphopyruvate hydratase activity
FCL45_RS04310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FCL45_RS04315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FCL45_RS04340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FCL45_RS04400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FCL45_RS04405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FCL45_RS04410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FCL45_RS04415	COG0242	peptide deformylase activity
FCL45_RS04420	COG2358	TRAP transporter, solute receptor (TAXI family
FCL45_RS04435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FCL45_RS04440	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS04440	COG0604	alcohol dehydrogenase
FCL45_RS04440	COG3321	synthase
FCL45_RS04475	COG1592	Rubrerythrin
FCL45_RS04485	COG3040	lipid binding
FCL45_RS04505	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
FCL45_RS04510	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FCL45_RS04515	COG1620	l-lactate permease
FCL45_RS04525	COG1620	l-lactate permease
FCL45_RS04530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FCL45_RS04545	COG0395	ABC-type sugar transport system, permease component
FCL45_RS04555	COG3842	ATPase activity
FCL45_RS04580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FCL45_RS04585	COG2233	PERMEase
FCL45_RS04590	COG0747	negative chemotaxis
FCL45_RS04595	COG0601	transmembrane transport
FCL45_RS04600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FCL45_RS04605	COG0444	Belongs to the ABC transporter superfamily
FCL45_RS04610	COG4608	Belongs to the ABC transporter superfamily
FCL45_RS04615	COG1414	Transcriptional regulator
FCL45_RS04620	COG3958	Transketolase
FCL45_RS04625	COG1280	lysine exporter protein (LysE YggA)
FCL45_RS04640	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FCL45_RS04640	COG0778	Nitroreductase
FCL45_RS04655	COG0471	metal ion transport
FCL45_RS04655	COG0490	domain, Protein
FCL45_RS04665	COG0179	Fumarylacetoacetate (FAA) hydrolase
FCL45_RS04680	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FCL45_RS04685	COG0730	response to heat
FCL45_RS04695	COG2186	Transcriptional regulator
FCL45_RS04705	COG0693	protein deglycase activity
FCL45_RS04715	COG0655	NAD(P)H dehydrogenase (quinone) activity
FCL45_RS04720	COG0659	secondary active sulfate transmembrane transporter activity
FCL45_RS04745	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FCL45_RS04770	COG1012	belongs to the aldehyde dehydrogenase family
FCL45_RS04775	COG2249	NAD(P)H dehydrogenase (quinone) activity
FCL45_RS04780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FCL45_RS04785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FCL45_RS04800	COG0356	it plays a direct role in the translocation of protons across the membrane
FCL45_RS04810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FCL45_RS04810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FCL45_RS04815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FCL45_RS04825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL45_RS04850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FCL45_RS04865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FCL45_RS04875	COG0456	acetyltransferase
FCL45_RS04880	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FCL45_RS04890	COG2249	NAD(P)H dehydrogenase (quinone) activity
FCL45_RS04895	COG2824	Alkylphosphonate utilization operon protein PhnA
FCL45_RS04920	COG0765	amino acid transport
FCL45_RS04945	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FCL45_RS04965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FCL45_RS04975	COG0247	lactate metabolic process
FCL45_RS04980	COG0277	FAD linked oxidase domain protein
FCL45_RS05000	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FCL45_RS05010	COG0039	L-malate dehydrogenase activity
FCL45_RS05050	COG3848	Pyruvate phosphate dikinase
FCL45_RS05050	COG0574	Belongs to the PEP-utilizing enzyme family
FCL45_RS05050	COG0574	Belongs to the PEP-utilizing enzyme family
FCL45_RS05050	COG3848	Pyruvate phosphate dikinase
FCL45_RS05055	COG3272	Protein of unknown function (DUF1722)
FCL45_RS05060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FCL45_RS05065	COG0427	acetyl-CoA hydrolase
FCL45_RS05075	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FCL45_RS05085	COG1659	Linocin_M18 bacteriocin protein
FCL45_RS05090	COG3046	protein related to deoxyribodipyrimidine photolyase
FCL45_RS05100	COG0415	Belongs to the DNA photolyase family
FCL45_RS05105	COG3301	Polysulphide reductase, NrfD
FCL45_RS05110	COG0437	4 iron, 4 sulfur cluster binding
FCL45_RS05125	COG2186	Transcriptional regulator
FCL45_RS05130	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FCL45_RS05160	COG1022	Amp-dependent synthetase and ligase
FCL45_RS05195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FCL45_RS05215	COG1111	helicase
FCL45_RS05215	COG1205	dead DEAH box helicase
FCL45_RS05230	COG0305	Participates in initiation and elongation during chromosome replication
FCL45_RS05285	COG0583	DNA-binding transcription factor activity
FCL45_RS05295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FCL45_RS05295	COG2199	diguanylate cyclase activity
FCL45_RS05345	COG0427	acetyl-CoA hydrolase
FCL45_RS05365	COG1309	transcriptional regulator
FCL45_RS05375	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FCL45_RS05385	COG1024	Enoyl-CoA hydratase
FCL45_RS05455	COG1253	flavin adenine dinucleotide binding
FCL45_RS05465	COG0398	Pfam SNARE associated Golgi protein
FCL45_RS05495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL45_RS05500	COG4597	amino acid ABC transporter
FCL45_RS05505	COG0765	amino acid transport
FCL45_RS05510	COG1126	abc transporter atp-binding protein
FCL45_RS05530	COG3273	potassium ion transport
FCL45_RS05530	COG0471	metal ion transport
FCL45_RS05535	COG0604	alcohol dehydrogenase
FCL45_RS05540	COG0583	DNA-binding transcription factor activity
FCL45_RS05550	COG3384	dioxygenase
FCL45_RS05565	COG2855	membrane
FCL45_RS05580	COG3852	Histidine kinase
FCL45_RS05585	COG2204	response regulator
FCL45_RS05600	COG2204	response regulator
FCL45_RS05610	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FCL45_RS05645	COG1304	FMN binding
FCL45_RS05660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FCL45_RS05670	COG0765	amino acid transport
FCL45_RS05695	COG3976	FMN-binding domain protein
FCL45_RS05695	COG1053	succinate dehydrogenase
FCL45_RS05760	COG0471	metal ion transport
FCL45_RS05760	COG0490	domain, Protein
FCL45_RS05765	COG2204	response regulator
FCL45_RS05770	COG4566	intracellular signal transduction
FCL45_RS05790	COG0745	RESPONSE REGULATOR receiver
FCL45_RS05795	COG2067	long-chain fatty acid transport protein
FCL45_RS05820	COG4191	Histidine kinase
FCL45_RS05835	COG0484	heat shock protein binding
FCL45_RS05845	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
FCL45_RS05880	COG0730	response to heat
FCL45_RS05945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS05960	COG0277	FAD linked oxidase domain protein
FCL45_RS05975	COG1278	Cold shock
FCL45_RS06005	COG2205	protein histidine kinase activity
FCL45_RS06005	COG2198	Histidine kinase
FCL45_RS06005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL45_RS06005	COG0784	Response regulator, receiver
FCL45_RS06020	COG2226	methyltransferase
FCL45_RS06080	COG3033	Beta-eliminating lyase
FCL45_RS06090	COG1522	sequence-specific DNA binding
FCL45_RS06100	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FCL45_RS06110	COG4294	response to UV
FCL45_RS06135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FCL45_RS06145	COG1012	belongs to the aldehyde dehydrogenase family
FCL45_RS06155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FCL45_RS06160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FCL45_RS06165	COG0459	protein refolding
FCL45_RS06175	COG1061	Type III restriction enzyme res subunit
FCL45_RS06225	COG0514	ATP-dependent DNA helicase (RecQ)
FCL45_RS06245	COG3273	potassium ion transport
FCL45_RS06245	COG0471	metal ion transport
FCL45_RS06270	COG0752	glycyl-tRNA synthetase alpha subunit
FCL45_RS06280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FCL45_RS06285	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FCL45_RS06330	COG0540	Belongs to the ATCase OTCase family
FCL45_RS06335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FCL45_RS06340	COG1489	DNA binding
FCL45_RS06345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FCL45_RS06355	COG0126	phosphoglycerate kinase activity
FCL45_RS06360	COG0149	triose-phosphate isomerase activity
FCL45_RS06375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FCL45_RS06380	COG1151	hydroxylamine reductase activity
FCL45_RS06385	COG1584	GPR1 FUN34 yaaH family protein
FCL45_RS06395	COG0673	inositol 2-dehydrogenase activity
FCL45_RS06420	COG0281	malic enzyme
FCL45_RS06435	COG1126	abc transporter atp-binding protein
FCL45_RS06440	COG2390	Transcriptional regulator
FCL45_RS06445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FCL45_RS06450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS06460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FCL45_RS06495	COG2204	response regulator
FCL45_RS06500	COG3852	Histidine kinase
FCL45_RS06510	COG2855	membrane
FCL45_RS06520	COG2855	membrane
FCL45_RS06550	COG0517	IMP dehydrogenase activity
FCL45_RS06560	COG4974	Belongs to the 'phage' integrase family
FCL45_RS06565	COG3385	transposase activity
FCL45_RS06610	COG0430	RNA-3'-phosphate cyclase activity
FCL45_RS06615	COG3005	denitrification pathway
FCL45_RS06620	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FCL45_RS06655	COG1509	lysine 2,3-aminomutase activity
FCL45_RS06665	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FCL45_RS06675	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FCL45_RS06680	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FCL45_RS06700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FCL45_RS06705	COG1116	anion transmembrane transporter activity
FCL45_RS06705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FCL45_RS06715	COG3706	GGDEF domain
FCL45_RS06720	COG2076	Multidrug Resistance protein
FCL45_RS06725	COG2207	Transcriptional regulator
FCL45_RS06725	COG1917	Cupin 2, conserved barrel domain protein
FCL45_RS06740	COG0243	molybdopterin cofactor binding
FCL45_RS06755	COG0437	4 iron, 4 sulfur cluster binding
FCL45_RS06760	COG5557	Pfam Polysulphide reductase, NrfD
FCL45_RS06765	COG1451	nucleotide metabolic process
FCL45_RS06800	COG0811	peptide transport
FCL45_RS06865	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FCL45_RS06890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FCL45_RS06900	COG5002	protein histidine kinase activity
FCL45_RS06905	COG0745	RESPONSE REGULATOR receiver
FCL45_RS06910	COG0463	Glycosyl transferase, family 2
FCL45_RS06915	COG3153	acetyltransferase
FCL45_RS06915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FCL45_RS06920	COG0864	Transcriptional regulator
FCL45_RS06935	COG0765	amino acid transport
FCL45_RS06940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL45_RS06945	COG0765	amino acid transport
FCL45_RS06960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FCL45_RS07005	COG2264	protein methyltransferase activity
FCL45_RS07015	COG3852	Histidine kinase
FCL45_RS07020	COG2204	response regulator
FCL45_RS07030	COG0318	PFAM AMP-dependent synthetase and ligase
FCL45_RS07030	COG0204	Acyl-transferase
FCL45_RS07045	COG3852	Histidine kinase
FCL45_RS07050	COG2204	response regulator
FCL45_RS07060	COG0437	4 iron, 4 sulfur cluster binding
FCL45_RS07120	COG1733	regulation of RNA biosynthetic process
FCL45_RS07130	COG1522	sequence-specific DNA binding
FCL45_RS07140	COG3622	Belongs to the hyi family
FCL45_RS07145	COG2084	Dehydrogenase
FCL45_RS07150	COG0840	transmembrane signaling receptor activity
FCL45_RS07165	COG4302	ethanolamine ammonia-lyase activity
FCL45_RS07170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS07185	COG2433	Pfam Transposase IS66
FCL45_RS07270	COG0693	protein deglycase activity
FCL45_RS07275	COG3257	ureidoglycine aminohydrolase activity
FCL45_RS07280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FCL45_RS07295	COG0765	amino acid transport
FCL45_RS07300	COG0765	amino acid transport
FCL45_RS07315	COG1322	Protein conserved in bacteria
FCL45_RS07340	COG1993	acr, cog1993
FCL45_RS07360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS07365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FCL45_RS07370	COG0537	adenosine 5'-monophosphoramidase activity
FCL45_RS07375	COG0475	glutathione-regulated potassium exporter activity
FCL45_RS07375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FCL45_RS07380	COG0542	response to heat
FCL45_RS07385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FCL45_RS07400	COG0598	Magnesium transport protein CorA
FCL45_RS07410	COG3264	Mechanosensitive ion channel
FCL45_RS07410	COG1196	nuclear chromosome segregation
FCL45_RS07425	COG1971	Probably functions as a manganese efflux pump
FCL45_RS07435	COG0674	pyruvate-flavodoxin oxidoreductase activity
FCL45_RS07435	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FCL45_RS07445	COG0129	dihydroxy-acid dehydratase activity
FCL45_RS07460	COG0513	Belongs to the DEAD box helicase family
FCL45_RS07465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FCL45_RS07470	COG0539	negative regulation of cytoplasmic translation
FCL45_RS07475	COG0776	regulation of translation
FCL45_RS07480	COG0009	L-threonylcarbamoyladenylate synthase
FCL45_RS07485	COG0516	GMP reductase activity
FCL45_RS07485	COG0517	IMP dehydrogenase activity
FCL45_RS07490	COG0519	Catalyzes the synthesis of GMP from XMP
FCL45_RS07490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FCL45_RS07500	COG0668	transmembrane transport
FCL45_RS07505	COG0837	glucose binding
FCL45_RS07535	COG0328	RNA-DNA hybrid ribonuclease activity
FCL45_RS07570	COG4628	conserved protein (DUF2132)
FCL45_RS07575	COG0513	Belongs to the DEAD box helicase family
FCL45_RS07585	COG2205	protein histidine kinase activity
FCL45_RS07585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL45_RS07585	COG2198	Histidine kinase
FCL45_RS07585	COG0784	Response regulator, receiver
FCL45_RS07590	COG0583	DNA-binding transcription factor activity
FCL45_RS07595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FCL45_RS07600	COG1854	S-ribosylhomocysteine lyase activity
FCL45_RS07625	COG2186	Transcriptional regulator
FCL45_RS07640	COG3401	FG-GAP repeat protein
FCL45_RS07650	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FCL45_RS07660	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FCL45_RS07665	COG2204	response regulator
FCL45_RS07670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FCL45_RS07675	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FCL45_RS07680	COG1027	Aspartate ammonia-lyase
FCL45_RS07685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FCL45_RS07700	COG3639	organic phosphonate transmembrane transporter activity
FCL45_RS07705	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FCL45_RS07710	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FCL45_RS07720	COG1858	cytochrome C peroxidase
FCL45_RS07735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FCL45_RS07765	COG0393	Putative heavy-metal-binding
FCL45_RS07795	COG1917	Cupin 2, conserved barrel domain protein
FCL45_RS07795	COG2207	Transcriptional regulator
FCL45_RS07810	COG0402	S-adenosylhomocysteine deaminase activity
FCL45_RS07820	COG0243	molybdopterin cofactor binding
FCL45_RS07825	COG1140	nitrate reductase beta subunit
FCL45_RS07845	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FCL45_RS07850	COG2204	response regulator
FCL45_RS07855	COG0405	Gamma-glutamyltransferase
FCL45_RS07865	COG0747	negative chemotaxis
FCL45_RS07880	COG0444	Belongs to the ABC transporter superfamily
FCL45_RS07885	COG4608	Belongs to the ABC transporter superfamily
FCL45_RS07890	COG1509	lysine 2,3-aminomutase activity
FCL45_RS07895	COG4106	trans-aconitate 2-methyltransferase activity
FCL45_RS07905	COG2226	methyltransferase
FCL45_RS07925	COG1022	Amp-dependent synthetase and ligase
FCL45_RS07945	COG0688	phosphatidylethanolamine metabolic process
FCL45_RS07970	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS07975	COG0183	Belongs to the thiolase family
FCL45_RS07980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FCL45_RS08000	COG0484	heat shock protein binding
FCL45_RS08005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FCL45_RS08010	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FCL45_RS08015	COG1321	iron dependent repressor
FCL45_RS08020	COG0538	isocitrate dehydrogenase activity
FCL45_RS08025	COG1049	propionate catabolic process, 2-methylcitrate cycle
FCL45_RS08035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FCL45_RS08045	COG0517	IMP dehydrogenase activity
FCL45_RS08085	COG1652	LysM domain
FCL45_RS08105	COG3119	arylsulfatase activity
FCL45_RS08145	COG0824	Thioesterase
FCL45_RS08150	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
FCL45_RS08160	COG0563	adenylate kinase activity
FCL45_RS08210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FCL45_RS08215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FCL45_RS08220	COG2920	part of a sulfur-relay system
FCL45_RS08225	COG0189	ligase activity
FCL45_RS08225	COG4067	protein conserved in archaea
FCL45_RS08240	COG0739	heme binding
FCL45_RS08245	COG0488	(ABC) transporter
FCL45_RS08255	COG2815	serine threonine protein kinase
FCL45_RS08255	COG0515	serine threonine protein kinase
FCL45_RS08260	COG4191	Histidine kinase
FCL45_RS08260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL45_RS08265	COG2204	response regulator
FCL45_RS08285	COG3069	C4-dicarboxylate transmembrane transporter activity
FCL45_RS08295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FCL45_RS08300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FCL45_RS08305	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FCL45_RS08330	COG3385	transposase activity
FCL45_RS08345	COG1216	Glycosyl transferase, family 2
FCL45_RS08355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FCL45_RS08365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FCL45_RS08445	COG0517	IMP dehydrogenase activity
FCL45_RS08485	COG0698	ribose 5-phosphate isomerase
FCL45_RS08500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FCL45_RS08505	COG3842	ATPase activity
FCL45_RS08510	COG1178	ABC-type Fe3 transport system permease component
FCL45_RS08535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FCL45_RS08550	COG0038	chloride channel
FCL45_RS08560	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FCL45_RS08565	COG2992	FlgJ-related protein
FCL45_RS08570	COG2816	NAD+ diphosphatase activity
FCL45_RS08580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FCL45_RS08590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FCL45_RS08595	COG0439	Biotin carboxylase
FCL45_RS08600	COG1253	flavin adenine dinucleotide binding
FCL45_RS08605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FCL45_RS08625	COG0686	Belongs to the AlaDH PNT family
FCL45_RS08640	COG2871	sodium ion transport
FCL45_RS08645	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FCL45_RS08650	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FCL45_RS08655	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FCL45_RS08660	COG1805	sodium ion transport
FCL45_RS08665	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FCL45_RS08695	COG1704	LemA family
FCL45_RS08705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL45_RS08720	COG2814	Major facilitator Superfamily
FCL45_RS08730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FCL45_RS08765	COG0148	phosphopyruvate hydratase activity
FCL45_RS08775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FCL45_RS08785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FCL45_RS08795	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FCL45_RS08800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FCL45_RS08810	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FCL45_RS08820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS08825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FCL45_RS08835	COG1802	Transcriptional regulator
FCL45_RS08850	COG1301	dicarboxylic acid transport
FCL45_RS08855	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FCL45_RS08860	COG0251	oxidation-reduction process
FCL45_RS08880	COG1234	tRNA 3'-trailer cleavage
FCL45_RS08890	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FCL45_RS08895	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FCL45_RS08900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FCL45_RS08940	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FCL45_RS08940	COG0674	pyruvate-flavodoxin oxidoreductase activity
FCL45_RS08945	COG1013	pyruvate-flavodoxin oxidoreductase activity
FCL45_RS08950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FCL45_RS08955	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FCL45_RS08970	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FCL45_RS08975	COG0525	valine-tRNA ligase activity
FCL45_RS09020	COG2205	protein histidine kinase activity
FCL45_RS09020	COG0784	Response regulator, receiver
FCL45_RS09040	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FCL45_RS09045	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS09065	COG1802	Transcriptional regulator
FCL45_RS09080	COG1773	rubredoxin
FCL45_RS09085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FCL45_RS09095	COG2826	transposase and inactivated derivatives, IS30 family
FCL45_RS09100	COG2963	transposase activity
FCL45_RS09130	COG0789	Transcriptional regulator
FCL45_RS09140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FCL45_RS09160	COG3706	GGDEF domain
FCL45_RS09160	COG5001	Diguanylate cyclase
FCL45_RS09160	COG4251	negative regulation of phosphorylation
FCL45_RS09160	COG2203	Gaf domain
FCL45_RS09195	COG1013	pyruvate-flavodoxin oxidoreductase activity
FCL45_RS09220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FCL45_RS09225	COG2076	Multidrug Resistance protein
FCL45_RS09230	COG0058	SHG alpha-glucan phosphorylase activity
FCL45_RS09245	COG0588	phosphoglycerate mutase activity
FCL45_RS09260	COG3829	transcription factor binding
FCL45_RS09260	COG3290	protein histidine kinase activity
FCL45_RS09275	COG1454	alcohol dehydrogenase
FCL45_RS09280	COG2414	aldehyde ferredoxin oxidoreductase
FCL45_RS09290	COG1301	dicarboxylic acid transport
FCL45_RS09295	COG0387	Pfam Sodium calcium exchanger
FCL45_RS09305	COG2208	phosphoserine phosphatase activity
FCL45_RS09310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FCL45_RS09335	COG3437	response regulator, receiver
FCL45_RS09345	COG3021	interspecies interaction between organisms
FCL45_RS09350	COG1811	Na channel or pump
FCL45_RS09360	COG2132	Multicopper oxidase
FCL45_RS09365	COG1234	tRNA 3'-trailer cleavage
FCL45_RS09420	COG2234	aminopeptidase activity
FCL45_RS09445	COG2226	methyltransferase
FCL45_RS09465	COG1803	Methylglyoxal synthase
FCL45_RS09495	COG1024	Enoyl-CoA hydratase
FCL45_RS09495	COG1250	3-hydroxyacyl-CoA dehydrogenase
FCL45_RS09500	COG0183	Belongs to the thiolase family
FCL45_RS09505	COG1960	acyl-CoA dehydrogenase activity
FCL45_RS09515	COG0446	pyridine nucleotide-disulphide oxidoreductase
FCL45_RS09515	COG1902	pentaerythritol trinitrate reductase activity
FCL45_RS09545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FCL45_RS09555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS09560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FCL45_RS09625	COG0513	Belongs to the DEAD box helicase family
FCL45_RS09635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FCL45_RS09655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS09665	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS09675	COG4302	ethanolamine ammonia-lyase activity
FCL45_RS09685	COG1349	DNA-binding transcription factor activity
FCL45_RS09690	COG1840	ABC-type Fe3 transport system, periplasmic component
FCL45_RS09695	COG3842	ATPase activity
FCL45_RS09720	COG0745	RESPONSE REGULATOR receiver
FCL45_RS09725	COG2205	protein histidine kinase activity
FCL45_RS09730	COG0517	IMP dehydrogenase activity
FCL45_RS09740	COG4974	Belongs to the 'phage' integrase family
FCL45_RS09750	COG1122	ATPase activity
FCL45_RS09770	COG1177	transmembrane transport
FCL45_RS09775	COG1176	ABC-type spermidine putrescine transport system, permease component I
FCL45_RS09780	COG3842	ATPase activity
FCL45_RS09785	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FCL45_RS09790	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS09795	COG1744	ABC transporter substrate-binding protein PnrA-like
FCL45_RS09805	COG4603	Belongs to the binding-protein-dependent transport system permease family
FCL45_RS09815	COG0402	S-adenosylhomocysteine deaminase activity
FCL45_RS09820	COG1714	RDD family
FCL45_RS09845	COG2814	Major facilitator Superfamily
FCL45_RS09865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FCL45_RS09870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FCL45_RS09875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS09895	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FCL45_RS09905	COG4608	Belongs to the ABC transporter superfamily
FCL45_RS09910	COG0444	Belongs to the ABC transporter superfamily
FCL45_RS09920	COG0601	transmembrane transport
FCL45_RS09925	COG0747	negative chemotaxis
FCL45_RS09945	COG2918	glutathione biosynthetic process
FCL45_RS09945	COG1181	Belongs to the D-alanine--D-alanine ligase family
FCL45_RS09970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS09975	COG1335	isochorismatase
FCL45_RS09980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FCL45_RS09985	COG4574	serine-type endopeptidase inhibitor activity
FCL45_RS09990	COG0439	Biotin carboxylase
FCL45_RS09995	COG5016	pyruvate
FCL45_RS09995	COG0511	ligase activity, forming carbon-carbon bonds
FCL45_RS10000	COG2226	methyltransferase
FCL45_RS10005	COG0789	Transcriptional regulator
FCL45_RS10010	COG1960	acyl-CoA dehydrogenase activity
FCL45_RS10015	COG2181	nitrate reductase activity
FCL45_RS10015	COG0247	lactate metabolic process
FCL45_RS10020	COG2086	electron transfer activity
FCL45_RS10025	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FCL45_RS10035	COG0824	Thioesterase
FCL45_RS10040	COG2067	long-chain fatty acid transport protein
FCL45_RS10050	COG1902	pentaerythritol trinitrate reductase activity
FCL45_RS10050	COG0446	pyridine nucleotide-disulphide oxidoreductase
FCL45_RS10055	COG0179	Fumarylacetoacetate (FAA) hydrolase
FCL45_RS10075	COG1121	(ABC) transporter
FCL45_RS10080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FCL45_RS10085	COG0531	amino acid
FCL45_RS10100	COG2205	protein histidine kinase activity
FCL45_RS10100	COG3437	response regulator, receiver
FCL45_RS10100	COG3850	Histidine kinase
FCL45_RS10100	COG4999	Histidine kinase
FCL45_RS10105	COG1063	alcohol dehydrogenase
FCL45_RS10110	COG0156	8-amino-7-oxononanoate synthase activity
FCL45_RS10130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL45_RS10135	COG0765	amino acid transport
FCL45_RS10150	COG1121	(ABC) transporter
FCL45_RS10155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FCL45_RS10160	COG1294	oxidase, subunit
FCL45_RS10165	COG1271	oxidase subunit
FCL45_RS10170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FCL45_RS10180	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FCL45_RS10225	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS10240	COG0191	fructose-bisphosphate aldolase activity
FCL45_RS10260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FCL45_RS10275	COG1047	Peptidyl-prolyl cis-trans
FCL45_RS10295	COG0259	pyridoxamine-phosphate oxidase activity
FCL45_RS10300	COG1280	lysine exporter protein (LysE YggA)
FCL45_RS10325	COG3290	protein histidine kinase activity
FCL45_RS10325	COG3829	transcription factor binding
FCL45_RS10335	COG1760	l-serine dehydratase
FCL45_RS10340	COG2414	aldehyde ferredoxin oxidoreductase
FCL45_RS10355	COG0596	Alpha beta hydrolase
FCL45_RS10365	COG1690	Belongs to the RtcB family
FCL45_RS10370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FCL45_RS10385	COG0395	ABC-type sugar transport system, permease component
FCL45_RS10390	COG1175	transmembrane transport
FCL45_RS10400	COG0564	pseudouridine synthase activity
FCL45_RS10410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FCL45_RS10415	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FCL45_RS10420	COG2201	protein-glutamate methylesterase activity
FCL45_RS10425	COG0534	Mate efflux family protein
FCL45_RS10440	COG1660	Displays ATPase and GTPase activities
FCL45_RS10465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL45_RS10475	COG4120	Belongs to the binding-protein-dependent transport system permease family
FCL45_RS10485	COG4807	Protein conserved in bacteria
FCL45_RS10520	COG2204	response regulator
FCL45_RS10530	COG3852	Histidine kinase
FCL45_RS10535	COG2204	response regulator
FCL45_RS10620	COG0504	CTP synthase activity
FCL45_RS10635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FCL45_RS10635	COG2169	Transcriptional regulator
FCL45_RS10640	COG1309	transcriptional regulator
FCL45_RS10665	COG0784	Response regulator, receiver
FCL45_RS10665	COG2205	protein histidine kinase activity
FCL45_RS10675	COG1595	DNA-templated transcription, initiation
FCL45_RS10695	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
FCL45_RS10700	COG3119	arylsulfatase activity
FCL45_RS10710	COG0723	plastoquinol--plastocyanin reductase activity
FCL45_RS10735	COG0494	nUDIX hydrolase
FCL45_RS10755	COG0517	IMP dehydrogenase activity
FCL45_RS10780	COG3385	transposase activity
FCL45_RS10815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FCL45_RS10820	COG2208	phosphoserine phosphatase activity
FCL45_RS10835	COG1335	isochorismatase
FCL45_RS10840	COG0471	metal ion transport
FCL45_RS10855	COG0446	pyridine nucleotide-disulphide oxidoreductase
FCL45_RS10890	COG1960	acyl-CoA dehydrogenase activity
FCL45_RS10895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FCL45_RS10900	COG1024	Enoyl-CoA hydratase
FCL45_RS10915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FCL45_RS10990	COG2208	phosphoserine phosphatase activity
FCL45_RS11015	COG0671	phosphoesterase, PA-phosphatase related
FCL45_RS11020	COG0493	'glutamate synthase
FCL45_RS11025	COG0070	glutamate synthase
FCL45_RS11025	COG0069	glutamate synthase activity
FCL45_RS11025	COG0067	glutamate synthase
FCL45_RS11040	COG0778	Nitroreductase
FCL45_RS11045	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FCL45_RS11055	COG0765	amino acid transport
FCL45_RS11065	COG0765	amino acid transport
FCL45_RS11070	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FCL45_RS11105	COG1846	Transcriptional regulator
FCL45_RS11110	COG0564	pseudouridine synthase activity
FCL45_RS11115	COG0513	Belongs to the DEAD box helicase family
FCL45_RS11135	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FCL45_RS11165	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FCL45_RS11175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FCL45_RS11195	COG2855	membrane
FCL45_RS11205	COG1785	Belongs to the alkaline phosphatase family
FCL45_RS11215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FCL45_RS11225	COG2195	Cleaves the N-terminal amino acid of tripeptides
FCL45_RS11230	COG0488	(ABC) transporter
FCL45_RS11235	COG0488	(ABC) transporter
FCL45_RS11240	COG1703	isobutyryl-CoA mutase activity
FCL45_RS11240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL45_RS11240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL45_RS11255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FCL45_RS11260	COG0508	dehydrogenase complex catalyzes the overall conversion of
FCL45_RS11265	COG0022	dehydrogenase e1 component
FCL45_RS11285	COG1966	Carbon starvation protein
FCL45_RS11300	COG0573	inorganic phosphate transmembrane transporter activity
FCL45_RS11305	COG0581	inorganic phosphate transmembrane transporter activity
FCL45_RS11310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FCL45_RS11355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FCL45_RS11395	COG2354	Protein conserved in bacteria
FCL45_RS11435	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FCL45_RS11440	COG0352	thiamine-phosphate diphosphorylase activity
FCL45_RS11445	COG1116	anion transmembrane transporter activity
FCL45_RS11450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FCL45_RS11455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FCL45_RS11505	COG1309	transcriptional regulator
FCL45_RS11515	COG2962	Rard protein
FCL45_RS11525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FCL45_RS11535	COG1085	galactose-1-phosphate uridylyltransferase
FCL45_RS11540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FCL45_RS11545	COG1609	Transcriptional regulator
FCL45_RS11550	COG3842	ATPase activity
FCL45_RS11565	COG0395	ABC-type sugar transport system, permease component
FCL45_RS11575	COG2183	response to ionizing radiation
FCL45_RS11585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FCL45_RS11590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FCL45_RS11595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FCL45_RS11600	COG0505	Belongs to the CarA family
FCL45_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS11615	COG0500	methyltransferase
FCL45_RS11620	COG2226	methyltransferase
FCL45_RS11655	COG1381	Involved in DNA repair and RecF pathway recombination
FCL45_RS11665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FCL45_RS11680	COG1968	undecaprenyl-diphosphatase activity
FCL45_RS11690	COG1648	precorrin-2 dehydrogenase activity
FCL45_RS11690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FCL45_RS11700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FCL45_RS11715	COG0793	Belongs to the peptidase S41A family
FCL45_RS11760	COG0543	2 iron, 2 sulfur cluster binding
FCL45_RS11765	COG0167	dihydroorotate dehydrogenase activity
FCL45_RS11770	COG0710	3-dehydroquinate dehydratase activity
FCL45_RS11775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FCL45_RS11780	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FCL45_RS11795	COG2951	lytic endotransglycosylase activity
FCL45_RS11805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FCL45_RS11810	COG1530	ribonuclease E activity
FCL45_RS11860	COG2204	response regulator
FCL45_RS11880	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FCL45_RS11890	COG2897	thiosulfate sulfurtransferase activity
FCL45_RS11920	COG4964	Belongs to the GSP D family
FCL45_RS11985	COG3267	Type II secretory pathway component ExeA
FCL45_RS11985	COG3409	Peptidoglycan-binding domain 1 protein
FCL45_RS11990	COG1459	type II secretion system
FCL45_RS12020	COG3156	type II secretion system protein K
FCL45_RS12045	COG1450	Type ii and iii secretion system protein
FCL45_RS12060	COG0346	lactoylglutathione lyase activity
FCL45_RS12065	COG0438	transferase activity, transferring glycosyl groups
FCL45_RS12070	COG0438	transferase activity, transferring glycosyl groups
FCL45_RS12075	COG0583	DNA-binding transcription factor activity
FCL45_RS12085	COG1045	serine acetyltransferase
FCL45_RS12090	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FCL45_RS12095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FCL45_RS12110	COG0058	SHG alpha-glucan phosphorylase activity
FCL45_RS12120	COG0589	response to stress
FCL45_RS12135	COG0571	ribonuclease III activity
FCL45_RS12145	COG0488	(ABC) transporter
FCL45_RS12165	COG0577	efflux transmembrane transporter activity
FCL45_RS12165	COG1136	(ABC) transporter
FCL45_RS12185	COG0786	glutamate:sodium symporter activity
FCL45_RS12195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FCL45_RS12200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL45_RS12205	COG1136	(ABC) transporter
FCL45_RS12210	COG0577	efflux transmembrane transporter activity
FCL45_RS12210	COG1136	(ABC) transporter
FCL45_RS12215	COG1136	(ABC) transporter
FCL45_RS12215	COG0577	efflux transmembrane transporter activity
FCL45_RS12230	COG1404	Belongs to the peptidase S8 family
FCL45_RS12240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FCL45_RS12245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FCL45_RS12250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FCL45_RS12250	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FCL45_RS12255	COG0517	IMP dehydrogenase activity
FCL45_RS12270	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FCL45_RS12280	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FCL45_RS12290	COG4067	protein conserved in archaea
FCL45_RS12290	COG0189	ligase activity
FCL45_RS12295	COG0189	ligase activity
FCL45_RS12295	COG0569	domain protein
FCL45_RS12300	COG3608	succinylglutamate desuccinylase aspartoacylase
FCL45_RS12305	COG2239	Acts as a magnesium transporter
FCL45_RS12340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS12345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS12350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FCL45_RS12365	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FCL45_RS12385	COG0733	neurotransmitter:sodium symporter activity
FCL45_RS12390	COG2081	HI0933 family
FCL45_RS12400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FCL45_RS12405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FCL45_RS12410	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FCL45_RS12415	COG0357	Ribosomal RNA small subunit methyltransferase G
FCL45_RS12420	COG0473	3-isopropylmalate dehydrogenase activity
FCL45_RS12425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FCL45_RS12430	COG2204	response regulator
FCL45_RS12445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FCL45_RS12450	COG1136	(ABC) transporter
FCL45_RS12460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FCL45_RS12465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FCL45_RS12480	COG0252	asparaginase activity
FCL45_RS12495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FCL45_RS12500	COG0443	Heat shock 70 kDa protein
FCL45_RS12600	COG1012	belongs to the aldehyde dehydrogenase family
FCL45_RS12615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FCL45_RS12620	COG0583	DNA-binding transcription factor activity
FCL45_RS12660	COG0517	IMP dehydrogenase activity
FCL45_RS12705	COG1047	Peptidyl-prolyl cis-trans
FCL45_RS12710	COG2814	Major facilitator Superfamily
FCL45_RS12715	COG0747	negative chemotaxis
FCL45_RS12720	COG0601	transmembrane transport
FCL45_RS12730	COG0444	Belongs to the ABC transporter superfamily
FCL45_RS12735	COG4608	Belongs to the ABC transporter superfamily
FCL45_RS12740	COG0791	NLP P60 protein
FCL45_RS12770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FCL45_RS12775	COG1519	Transferase
FCL45_RS12790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FCL45_RS12805	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS12810	COG0424	maF-like protein
FCL45_RS12820	COG0305	Participates in initiation and elongation during chromosome replication
FCL45_RS12825	COG5001	Diguanylate cyclase
FCL45_RS12830	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FCL45_RS12840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FCL45_RS12845	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FCL45_RS12850	COG0306	phosphate transporter
FCL45_RS12855	COG1392	Phosphate transport regulator
FCL45_RS12865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FCL45_RS12870	COG0493	'glutamate synthase
FCL45_RS12885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FCL45_RS12890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FCL45_RS12895	COG0402	S-adenosylhomocysteine deaminase activity
FCL45_RS12910	COG0799	negative regulation of ribosome biogenesis
FCL45_RS12920	COG0779	Required for maturation of 30S ribosomal subunits
FCL45_RS12925	COG0195	Participates in both transcription termination and antitermination
FCL45_RS12925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FCL45_RS12935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FCL45_RS12935	COG3064	Membrane
FCL45_RS12940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FCL45_RS12950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FCL45_RS12955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FCL45_RS12960	COG1185	polyribonucleotide nucleotidyltransferase activity
FCL45_RS12965	COG0756	dUTP diphosphatase activity
FCL45_RS12970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FCL45_RS12975	COG1534	Rna-binding protein
FCL45_RS12985	COG1388	LysM domain
FCL45_RS12985	COG0791	NLP P60 protein
FCL45_RS13000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FCL45_RS13015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL45_RS13035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FCL45_RS13045	COG0011	TIGRFAM Protein of
FCL45_RS13060	COG0084	hydrolase, TatD family'
FCL45_RS13080	COG0243	molybdopterin cofactor binding
FCL45_RS13085	COG0583	DNA-binding transcription factor activity
FCL45_RS13095	COG2095	MarC family integral membrane protein
FCL45_RS13115	COG0318	PFAM AMP-dependent synthetase and ligase
FCL45_RS13125	COG1515	deoxyribonuclease V activity
FCL45_RS13135	COG5002	protein histidine kinase activity
FCL45_RS13160	COG1233	COG1233 Phytoene dehydrogenase and related
FCL45_RS13175	COG5002	protein histidine kinase activity
FCL45_RS13245	COG3328	transposase activity
FCL45_RS13255	COG2132	Multicopper oxidase
FCL45_RS13265	COG2918	glutathione biosynthetic process
FCL45_RS13265	COG0189	ligase activity
FCL45_RS13290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FCL45_RS13300	COG0445	tRNA wobble uridine modification
FCL45_RS13350	COG5002	protein histidine kinase activity
FCL45_RS13390	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FCL45_RS13395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FCL45_RS13410	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FCL45_RS13415	COG1556	Lactate utilization protein
FCL45_RS13420	COG1139	Iron-sulfur cluster binding protein
FCL45_RS13425	COG0247	lactate metabolic process
FCL45_RS13480	COG2046	Belongs to the sulfate adenylyltransferase family
FCL45_RS13480	COG0529	Catalyzes the synthesis of activated sulfate
FCL45_RS13490	COG1454	alcohol dehydrogenase
FCL45_RS13505	COG0784	Response regulator, receiver
FCL45_RS13505	COG0643	Histidine kinase
FCL45_RS13505	COG2198	Histidine kinase
FCL45_RS13515	COG0745	RESPONSE REGULATOR receiver
FCL45_RS13530	COG0840	transmembrane signaling receptor activity
FCL45_RS13540	COG0708	Exodeoxyribonuclease III
FCL45_RS13545	COG3108	Peptidase M15
FCL45_RS13575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL45_RS13580	COG0463	Glycosyl transferase, family 2
FCL45_RS13590	COG2033	superoxide reductase activity
FCL45_RS13615	COG1845	cytochrome c oxidase, subunit III
FCL45_RS13630	COG0109	protoheme IX farnesyltransferase activity
FCL45_RS13645	COG1773	rubredoxin
FCL45_RS13650	COG0492	ferredoxin-NADP+ reductase activity
FCL45_RS13655	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FCL45_RS13660	COG1546	Belongs to the CinA family
FCL45_RS13660	COG1058	Belongs to the CinA family
FCL45_RS13665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL45_RS13670	COG0482	sulfurtransferase activity
FCL45_RS13680	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FCL45_RS13680	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FCL45_RS13690	COG0436	Aminotransferase
FCL45_RS13695	COG0784	Response regulator, receiver
FCL45_RS13695	COG3437	response regulator, receiver
FCL45_RS13705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FCL45_RS13725	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FCL45_RS13765	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FCL45_RS13770	COG3842	ATPase activity
FCL45_RS13790	COG1881	PFAM PEBP family protein
FCL45_RS13795	COG0626	cystathionine gamma-synthase activity
FCL45_RS13800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS13815	COG0745	RESPONSE REGULATOR receiver
FCL45_RS13820	COG2205	protein histidine kinase activity
FCL45_RS13850	COG1640	4-alpha-glucanotransferase
FCL45_RS13860	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FCL45_RS13865	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FCL45_RS13875	COG0163	prenyltransferase activity
FCL45_RS13880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FCL45_RS13890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FCL45_RS13895	COG1090	epimerase
FCL45_RS13905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FCL45_RS13935	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS13940	COG0612	Peptidase, M16
FCL45_RS13960	COG1120	ATPase activity
FCL45_RS13965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FCL45_RS13975	COG0616	signal peptide processing
FCL45_RS13980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FCL45_RS13985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FCL45_RS14010	COG0613	PHP domain protein
FCL45_RS14015	COG2204	response regulator
FCL45_RS14020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FCL45_RS14025	COG2835	tetraacyldisaccharide 4'-kinase activity
FCL45_RS14030	COG0574	Belongs to the PEP-utilizing enzyme family
FCL45_RS14030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FCL45_RS14035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FCL45_RS14055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FCL45_RS14085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FCL45_RS14090	COG1678	Uncharacterized ACR, COG1678
FCL45_RS14100	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FCL45_RS14105	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FCL45_RS14110	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FCL45_RS14115	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FCL45_RS14130	COG1643	Atp-dependent helicase
FCL45_RS14135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FCL45_RS14140	COG1509	lysine 2,3-aminomutase activity
FCL45_RS14145	COG0281	malic enzyme
FCL45_RS14150	COG1278	Cold shock
FCL45_RS14155	COG0596	Alpha beta hydrolase
FCL45_RS14160	COG0318	PFAM AMP-dependent synthetase and ligase
FCL45_RS14165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FCL45_RS14175	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FCL45_RS14185	COG0823	Involved in the tonB-independent uptake of proteins
FCL45_RS14205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FCL45_RS14210	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS14225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FCL45_RS14230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FCL45_RS14240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FCL45_RS14250	COG0728	peptidoglycan biosynthetic process
FCL45_RS14255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FCL45_RS14260	COG0521	Mo-molybdopterin cofactor biosynthetic process
FCL45_RS14265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FCL45_RS14275	COG4106	trans-aconitate 2-methyltransferase activity
FCL45_RS14280	COG2239	Acts as a magnesium transporter
FCL45_RS14290	COG1253	flavin adenine dinucleotide binding
FCL45_RS14295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FCL45_RS14300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FCL45_RS14310	COG0495	leucyl-tRNA aminoacylation
FCL45_RS14315	COG0305	Participates in initiation and elongation during chromosome replication
FCL45_RS14320	COG0359	binds to the 23S rRNA
FCL45_RS14330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FCL45_RS14335	COG0360	Binds together with S18 to 16S ribosomal RNA
FCL45_RS14340	COG3956	TIGRFAM MazG family protein
FCL45_RS14350	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FCL45_RS14355	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FCL45_RS14360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FCL45_RS14365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FCL45_RS14370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FCL45_RS14375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FCL45_RS14380	COG2201	protein-glutamate methylesterase activity
FCL45_RS14385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FCL45_RS14390	COG0517	IMP dehydrogenase activity
FCL45_RS14390	COG0516	GMP reductase activity
FCL45_RS14395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FCL45_RS14395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FCL45_RS14410	COG1530	ribonuclease E activity
FCL45_RS14415	COG1215	transferase activity, transferring glycosyl groups
FCL45_RS14430	COG3385	transposase activity
FCL45_RS14450	COG0517	IMP dehydrogenase activity
FCL45_RS14475	COG3385	transposase activity
FCL45_RS14485	COG0484	heat shock protein binding
FCL45_RS14495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FCL45_RS14500	COG4166	transmembrane transport
FCL45_RS14505	COG1278	Cold shock
FCL45_RS14510	COG0802	atpase or kinase
FCL45_RS14530	COG0745	RESPONSE REGULATOR receiver
FCL45_RS14560	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FCL45_RS14565	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FCL45_RS14575	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FCL45_RS14580	COG1797	cobyrinic acid a,c-diamide synthase activity
FCL45_RS14590	COG0105	UTP biosynthetic process
FCL45_RS14605	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FCL45_RS14610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FCL45_RS14620	COG0432	Pfam Uncharacterised protein family UPF0047
FCL45_RS14625	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FCL45_RS14630	COG1663	tetraacyldisaccharide 4'-kinase activity
FCL45_RS14635	COG0683	leucine binding
FCL45_RS14660	COG0673	inositol 2-dehydrogenase activity
FCL45_RS14665	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FCL45_RS14670	COG1193	negative regulation of DNA recombination
FCL45_RS14675	COG0564	pseudouridine synthase activity
FCL45_RS14680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FCL45_RS14685	COG0720	synthase
FCL45_RS14695	COG0606	chelatase, subunit chli
FCL45_RS14710	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FCL45_RS14745	COG1122	ATPase activity
FCL45_RS14770	COG1403	HNH endonuclease
FCL45_RS14775	COG0517	IMP dehydrogenase activity
FCL45_RS14845	COG1205	dead DEAH box helicase
FCL45_RS14845	COG1111	helicase
FCL45_RS14855	COG1619	proteins homologs of microcin C7 resistance protein MccF
FCL45_RS14860	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FCL45_RS14885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL45_RS14895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FCL45_RS14900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FCL45_RS14900	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FCL45_RS14905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FCL45_RS14915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FCL45_RS14920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FCL45_RS14930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FCL45_RS14940	COG0259	pyridoxamine-phosphate oxidase activity
FCL45_RS14945	COG3260	NADH ubiquinone oxidoreductase 20
FCL45_RS14950	COG0649	NAD binding
FCL45_RS14950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL45_RS14950	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL45_RS14955	COG0651	ATP synthesis coupled electron transport
FCL45_RS14970	COG0651	ATP synthesis coupled electron transport
FCL45_RS14995	COG4399	Belongs to the UPF0754 family
FCL45_RS15000	COG0546	phosphoglycolate phosphatase activity
FCL45_RS15010	COG1053	succinate dehydrogenase
FCL45_RS15020	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
FCL45_RS15045	COG0308	aminopeptidase N
FCL45_RS15050	COG0436	Aminotransferase
FCL45_RS15055	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FCL45_RS15065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FCL45_RS15070	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FCL45_RS15075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS15080	COG2204	response regulator
FCL45_RS15090	COG0107	imidazoleglycerol-phosphate synthase activity
FCL45_RS15100	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FCL45_RS15115	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FCL45_RS15130	COG0077	Prephenate dehydratase
FCL45_RS15130	COG1605	Chorismate mutase
FCL45_RS15135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FCL45_RS15145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FCL45_RS15150	COG1979	alcohol dehydrogenase
FCL45_RS15160	COG2501	S4 domain
FCL45_RS15170	COG1227	inorganic diphosphatase activity
FCL45_RS15190	COG0243	molybdopterin cofactor binding
FCL45_RS15200	COG0488	(ABC) transporter
FCL45_RS15210	COG0009	L-threonylcarbamoyladenylate synthase
FCL45_RS15215	COG0151	Belongs to the GarS family
FCL45_RS15220	COG1309	transcriptional regulator
FCL45_RS15225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FCL45_RS15240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FCL45_RS15245	COG0481	GTPase activity
FCL45_RS15265	COG1012	belongs to the aldehyde dehydrogenase family
FCL45_RS15300	COG1760	l-serine dehydratase
FCL45_RS15310	COG2205	protein histidine kinase activity
FCL45_RS15320	COG2204	response regulator
FCL45_RS15330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FCL45_RS15335	COG4106	trans-aconitate 2-methyltransferase activity
FCL45_RS15345	COG0156	8-amino-7-oxononanoate synthase activity
FCL45_RS15355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FCL45_RS15365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FCL45_RS15370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FCL45_RS15375	COG2884	Cell division ATP-binding protein ftsE
FCL45_RS15380	COG2177	Part of the ABC transporter FtsEX involved in
FCL45_RS15390	COG0793	Belongs to the peptidase S41A family
FCL45_RS15405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FCL45_RS15430	COG1279	arginine transmembrane transporter activity
FCL45_RS15435	COG0583	DNA-binding transcription factor activity
FCL45_RS15445	COG1683	Conserved Protein
FCL45_RS15465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FCL45_RS15470	COG1333	cytochrome c biogenesis protein
FCL45_RS15485	COG0751	glycine-tRNA ligase activity
FCL45_RS15490	COG1469	GTP cyclohydrolase I activity
FCL45_RS15495	COG2204	response regulator
FCL45_RS15505	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FCL45_RS15510	COG0315	cyclic pyranopterin monophosphate synthase activity
FCL45_RS15515	COG0484	heat shock protein binding
FCL45_RS15520	COG1758	RNA polymerase activity
FCL45_RS15525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FCL45_RS15530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FCL45_RS15535	COG0805	protein transport
FCL45_RS15570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FCL45_RS15575	COG2046	Belongs to the sulfate adenylyltransferase family
FCL45_RS15585	COG2608	mercury ion transmembrane transporter activity
FCL45_RS15625	COG3852	Histidine kinase
FCL45_RS15655	COG2433	Pfam Transposase IS66
FCL45_RS15690	COG1131	(ABC) transporter
FCL45_RS15740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FCL45_RS15750	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FCL45_RS15760	COG0778	Nitroreductase
FCL45_RS15775	COG2204	response regulator
FCL45_RS15780	COG2807	transmembrane transport
FCL45_RS15785	COG0215	cysteine-tRNA ligase activity
FCL45_RS15790	COG1355	regulation of microtubule-based process
FCL45_RS15805	COG1410	methionine synthase
FCL45_RS15805	COG0646	methionine synthase
FCL45_RS15810	COG1410	methionine synthase
FCL45_RS15810	COG0646	methionine synthase
FCL45_RS15825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FCL45_RS15840	COG0037	tRNA processing
FCL45_RS15850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL45_RS15855	COG0489	protein tyrosine kinase activity
FCL45_RS15860	COG0552	protein localization to endoplasmic reticulum
FCL45_RS15870	COG0436	Aminotransferase
FCL45_RS15890	COG1213	nucleotidyl transferase
FCL45_RS15895	COG3494	Protein of unknown function (DUF1009)
FCL45_RS15900	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FCL45_RS15905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FCL45_RS15910	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FCL45_RS15915	COG3876	Protein conserved in bacteria
FCL45_RS15920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FCL45_RS15925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FCL45_RS15950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FCL45_RS15950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FCL45_RS15955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FCL45_RS15960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FCL45_RS15965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FCL45_RS15970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FCL45_RS15985	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FCL45_RS15990	COG0045	succinate-CoA ligase (ADP-forming) activity
FCL45_RS16000	COG1013	pyruvate-flavodoxin oxidoreductase activity
FCL45_RS16005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FCL45_RS16005	COG0674	pyruvate-flavodoxin oxidoreductase activity
FCL45_RS16015	COG1802	Transcriptional regulator
FCL45_RS16020	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FCL45_RS16030	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FCL45_RS16035	COG3012	SEC-C Motif Domain Protein
FCL45_RS16040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FCL45_RS16045	COG0670	Belongs to the BI1 family
FCL45_RS16055	COG1215	transferase activity, transferring glycosyl groups
FCL45_RS16065	COG1215	transferase activity, transferring glycosyl groups
FCL45_RS16070	COG0463	Glycosyl transferase, family 2
FCL45_RS16090	COG1216	Glycosyl transferase, family 2
FCL45_RS16125	COG2433	Pfam Transposase IS66
FCL45_RS16145	COG0110	maltose O-acetyltransferase activity
FCL45_RS16160	COG0463	Glycosyl transferase, family 2
FCL45_RS16165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FCL45_RS16175	COG1132	(ABC) transporter
FCL45_RS16185	COG4191	Histidine kinase
FCL45_RS16195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FCL45_RS16200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FCL45_RS16205	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FCL45_RS16210	COG1047	Peptidyl-prolyl cis-trans
FCL45_RS16220	COG1525	nuclease
FCL45_RS16225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FCL45_RS16290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FCL45_RS16295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FCL45_RS16300	COG0740	serine-type endopeptidase activity
FCL45_RS16305	COG0544	peptidyl-prolyl cis-trans isomerase activity
FCL45_RS16315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FCL45_RS16315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FCL45_RS16320	COG1702	phosphate starvation-inducible protein PhoH
FCL45_RS16325	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FCL45_RS16335	COG0582	viral genome integration into host DNA
FCL45_RS16445	COG0517	IMP dehydrogenase activity
FCL45_RS16450	COG2356	endonuclease I
FCL45_RS16475	COG2433	Pfam Transposase IS66
FCL45_RS16565	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FCL45_RS16570	COG0135	phosphoribosylanthranilate isomerase activity
FCL45_RS16575	COG0134	indole-3-glycerol-phosphate synthase activity
FCL45_RS16580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FCL45_RS16585	COG0512	Glutamine amidotransferase of anthranilate synthase
FCL45_RS16595	COG0268	Binds directly to 16S ribosomal RNA
FCL45_RS16610	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FCL45_RS16615	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FCL45_RS16620	COG0138	bifunctional purine biosynthesis protein purh
FCL45_RS16625	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FCL45_RS16630	COG1469	GTP cyclohydrolase I activity
FCL45_RS16645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FCL45_RS16650	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FCL45_RS16665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FCL45_RS16675	COG0791	NLP P60 protein
FCL45_RS16680	COG3028	Belongs to the UPF0307 family
FCL45_RS16695	COG0303	'Molybdopterin
FCL45_RS16700	COG1910	domain protein
FCL45_RS16720	COG1254	Belongs to the acylphosphatase family
FCL45_RS16725	COG4172	Belongs to the ABC transporter superfamily
FCL45_RS16730	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FCL45_RS16735	COG0322	excinuclease ABC activity
FCL45_RS16745	COG1216	Glycosyl transferase, family 2
FCL45_RS16745	COG0438	transferase activity, transferring glycosyl groups
FCL45_RS16755	COG1519	Transferase
FCL45_RS16760	COG2333	competence protein COMEC
FCL45_RS16760	COG0658	competence protein
FCL45_RS16770	COG1611	Belongs to the LOG family
FCL45_RS16780	COG1921	L-seryl-tRNASec selenium transferase activity
FCL45_RS16810	COG1115	amino acid carrier protein
FCL45_RS16820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL45_RS16825	COG4215	(ABC) transporter
FCL45_RS16865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FCL45_RS16880	COG0058	SHG alpha-glucan phosphorylase activity
FCL45_RS16890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FCL45_RS16895	COG0129	dihydroxy-acid dehydratase activity
FCL45_RS16900	COG3181	Tripartite tricarboxylate transporter family receptor
FCL45_RS16915	COG1609	Transcriptional regulator
FCL45_RS16920	COG1691	(AIR) carboxylase
FCL45_RS16930	COG2721	sulfolactate sulfo-lyase activity
FCL45_RS16935	COG2721	sulfolactate sulfo-lyase activity
FCL45_RS16945	COG0446	pyridine nucleotide-disulphide oxidoreductase
FCL45_RS16955	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FCL45_RS16960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL45_RS16970	COG2414	aldehyde ferredoxin oxidoreductase
FCL45_RS16975	COG2721	sulfolactate sulfo-lyase activity
FCL45_RS16980	COG2721	sulfolactate sulfo-lyase activity
FCL45_RS16995	COG0482	sulfurtransferase activity
FCL45_RS17015	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FCL45_RS17020	COG1067	ATP-dependent peptidase activity
FCL45_RS17030	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS17035	COG1611	Belongs to the LOG family
FCL45_RS17040	COG0133	tryptophan synthase activity
FCL45_RS17050	COG0243	molybdopterin cofactor binding
FCL45_RS17055	COG0437	4 iron, 4 sulfur cluster binding
FCL45_RS17060	COG3381	protein complex oligomerization
FCL45_RS17075	COG1671	Belongs to the UPF0178 family
FCL45_RS17090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FCL45_RS17115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FCL45_RS17120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FCL45_RS17125	COG0778	Nitroreductase
FCL45_RS17130	COG0569	domain protein
FCL45_RS17130	COG2985	domain, Protein
FCL45_RS17140	COG0517	IMP dehydrogenase activity
FCL45_RS17150	COG4974	Belongs to the 'phage' integrase family
FCL45_RS17165	COG1228	amidohydrolase
FCL45_RS17170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FCL45_RS17175	COG2986	histidine ammonia-lyase
FCL45_RS17190	COG2414	aldehyde ferredoxin oxidoreductase
FCL45_RS17230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FCL45_RS17235	COG2204	response regulator
FCL45_RS17260	COG0697	spore germination
FCL45_RS17265	COG3530	Putative quorum-sensing-regulated virulence factor
FCL45_RS17290	COG0543	2 iron, 2 sulfur cluster binding
FCL45_RS17320	COG0646	methionine synthase
FCL45_RS17320	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FCL45_RS17335	COG1233	COG1233 Phytoene dehydrogenase and related
FCL45_RS17370	COG3852	Histidine kinase
FCL45_RS17375	COG0247	lactate metabolic process
FCL45_RS17375	COG2181	nitrate reductase activity
FCL45_RS17415	COG1151	hydroxylamine reductase activity
FCL45_RS17445	COG1151	hydroxylamine reductase activity
FCL45_RS17465	COG1592	Rubrerythrin
FCL45_RS17480	COG2873	o-acetylhomoserine
FCL45_RS17490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FCL45_RS17495	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FCL45_RS17520	COG2239	Acts as a magnesium transporter
FCL45_RS17555	COG3385	transposase activity
FCL45_RS17590	COG4372	Transposase
FCL45_RS17610	COG4974	Belongs to the 'phage' integrase family
FCL45_RS17615	COG0427	acetyl-CoA hydrolase
FCL45_RS17630	COG1388	LysM domain
FCL45_RS17630	COG1376	ErfK ybiS ycfS ynhG family protein
FCL45_RS17635	COG1960	acyl-CoA dehydrogenase activity
FCL45_RS17640	COG1024	Enoyl-CoA hydratase
FCL45_RS17655	COG1250	3-hydroxyacyl-CoA dehydrogenase
FCL45_RS17665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FCL45_RS17670	COG1960	acyl-CoA dehydrogenase activity
FCL45_RS17675	COG1309	transcriptional regulator
FCL45_RS17680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL45_RS17680	COG1703	isobutyryl-CoA mutase activity
FCL45_RS17680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL45_RS17750	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FCL45_RS17760	COG2204	response regulator
FCL45_RS17770	COG0574	Belongs to the PEP-utilizing enzyme family
FCL45_RS17770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FCL45_RS17780	COG0730	response to heat
FCL45_RS17790	COG4251	negative regulation of phosphorylation
FCL45_RS17790	COG3706	GGDEF domain
FCL45_RS17790	COG2203	Gaf domain
FCL45_RS17790	COG5001	Diguanylate cyclase
FCL45_RS17800	COG0243	molybdopterin cofactor binding
FCL45_RS17805	COG2201	protein-glutamate methylesterase activity
FCL45_RS17810	COG4191	Histidine kinase
FCL45_RS17820	COG1846	Transcriptional regulator
FCL45_RS17825	COG1511	domain protein
FCL45_RS17825	COG3264	Mechanosensitive ion channel
FCL45_RS17845	COG0517	IMP dehydrogenase activity
FCL45_RS17845	COG0516	GMP reductase activity
FCL45_RS17855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FCL45_RS17865	COG0511	ligase activity, forming carbon-carbon bonds
FCL45_RS17870	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FCL45_RS17880	COG0346	lactoylglutathione lyase activity
FCL45_RS17885	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL45_RS17885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL45_RS17890	COG1703	isobutyryl-CoA mutase activity
FCL45_RS17895	COG0628	permease
FCL45_RS17930	COG0631	protein serine/threonine phosphatase activity
FCL45_RS17945	COG4191	Histidine kinase
FCL45_RS17955	COG0517	IMP dehydrogenase activity
FCL45_RS17985	COG0358	DNA primase activity
FCL45_RS17990	COG4974	Belongs to the 'phage' integrase family
FCL45_RS18000	COG0517	IMP dehydrogenase activity
FCL45_RS18005	COG4974	Belongs to the 'phage' integrase family
FCL45_RS18015	COG0517	IMP dehydrogenase activity
FCL45_RS18020	COG3385	transposase activity
FCL45_RS18050	COG4974	Belongs to the 'phage' integrase family
FCL45_RS18070	COG0588	phosphoglycerate mutase activity
FCL45_RS18085	COG0058	SHG alpha-glucan phosphorylase activity
FCL45_RS18090	COG3647	Membrane
FCL45_RS18120	COG4948	Mandelate Racemase Muconate Lactonizing
FCL45_RS18130	COG0741	lytic transglycosylase activity
FCL45_RS18135	COG0628	permease
FCL45_RS18150	COG1566	PFAM secretion protein HlyD family protein
FCL45_RS18160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FCL45_RS18165	COG0418	dihydroorotase activity
FCL45_RS18170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FCL45_RS18190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FCL45_RS18195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FCL45_RS18200	COG0045	succinate-CoA ligase (ADP-forming) activity
FCL45_RS18215	COG2204	response regulator
FCL45_RS18220	COG1584	GPR1 FUN34 yaaH family protein
FCL45_RS18225	COG0577	efflux transmembrane transporter activity
FCL45_RS18225	COG1136	(ABC) transporter
FCL45_RS18230	COG1136	(ABC) transporter
FCL45_RS18230	COG0577	efflux transmembrane transporter activity
FCL45_RS18260	COG1960	acyl-CoA dehydrogenase activity
FCL45_RS18285	COG0023	Translation Initiation Factor
FCL45_RS18290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FCL45_RS18315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FCL45_RS18320	COG0277	FAD linked oxidase domain protein
FCL45_RS18325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FCL45_RS18330	COG1074	ATP-dependent DNA helicase activity
FCL45_RS18335	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FCL45_RS18350	COG0589	response to stress
FCL45_RS18365	COG1022	Amp-dependent synthetase and ligase
FCL45_RS18370	COG2226	methyltransferase
FCL45_RS18380	COG0017	Asparaginyl-tRNA synthetase
FCL45_RS18400	COG0131	Imidazoleglycerol-phosphate dehydratase
FCL45_RS18410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FCL45_RS18415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FCL45_RS18420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FCL45_RS18425	COG0101	tRNA pseudouridine synthase activity
FCL45_RS18430	COG0583	DNA-binding transcription factor activity
FCL45_RS18435	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL45_RS18440	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL45_RS18445	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL45_RS18450	COG0649	NAD binding
FCL45_RS18455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FCL45_RS18465	COG0839	Belongs to the complex I subunit 6 family
FCL45_RS18470	COG0713	ATP synthesis coupled electron transport
FCL45_RS18475	COG0651	ATP synthesis coupled electron transport
FCL45_RS18495	COG1007	ATP synthesis coupled electron transport
FCL45_RS18500	COG0501	Belongs to the peptidase M48B family
FCL45_RS18555	COG4656	Part of a membrane complex involved in electron transport
FCL45_RS18560	COG4658	electron transport chain
FCL45_RS18565	COG4659	FMN binding
FCL45_RS18570	COG4660	Part of a membrane complex involved in electron transport
FCL45_RS18575	COG4657	Part of a membrane complex involved in electron transport
FCL45_RS18580	COG0493	'glutamate synthase
FCL45_RS18585	COG4978	Transcriptional regulator
FCL45_RS18585	COG0789	Transcriptional regulator
FCL45_RS18605	COG1454	alcohol dehydrogenase
FCL45_RS18605	COG1012	belongs to the aldehyde dehydrogenase family
FCL45_RS18610	COG1882	Formate acetyltransferase
FCL45_RS18615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FCL45_RS18625	COG1454	alcohol dehydrogenase
FCL45_RS18625	COG1012	belongs to the aldehyde dehydrogenase family
FCL45_RS18635	COG4869	propanediol catabolic process
FCL45_RS18640	COG4820	ethanolamine utilization protein (EutJ)
FCL45_RS18695	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FCL45_RS18700	COG4149	molybdate abc transporter
FCL45_RS18705	COG0725	ABC transporter, periplasmic molybdate-binding protein
FCL45_RS18730	COG0330	HflC and HflK could
FCL45_RS18735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FCL45_RS18740	COG0205	6-phosphofructokinase activity
FCL45_RS18750	COG0640	Transcriptional regulator
FCL45_RS18755	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FCL45_RS18765	COG1164	Oligoendopeptidase f
FCL45_RS18790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FCL45_RS18795	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FCL45_RS18800	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FCL45_RS18810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FCL45_RS18815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FCL45_RS18820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FCL45_RS18825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FCL45_RS18830	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FCL45_RS18835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FCL45_RS18835	COG0072	phenylalanine-tRNA ligase activity
FCL45_RS18890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FCL45_RS18905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FCL45_RS18905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FCL45_RS18915	COG1879	ABC-type sugar transport system periplasmic component
FCL45_RS18935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FCL45_RS18945	COG2205	protein histidine kinase activity
FCL45_RS18945	COG0784	Response regulator, receiver
FCL45_RS18965	COG2172	sigma factor antagonist activity
FCL45_RS18970	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FCL45_RS18975	COG1494	fructose-1,6-bisphosphatase
FCL45_RS19000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FCL45_RS19005	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FCL45_RS19015	COG0587	DNA-directed DNA polymerase activity
FCL45_RS19030	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FCL45_RS19035	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FCL45_RS19040	COG4974	Belongs to the 'phage' integrase family
FCL45_RS19045	COG1722	exodeoxyribonuclease VII activity
FCL45_RS19055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FCL45_RS19080	COG0805	protein transport
FCL45_RS19090	COG2827	Endonuclease containing a URI domain
FCL45_RS19100	COG3852	Histidine kinase
FCL45_RS19130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FCL45_RS19140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FCL45_RS19145	COG0254	rRNA binding
FCL45_RS19150	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FCL45_RS19155	COG0237	dephospho-CoA kinase activity
FCL45_RS19160	COG0564	pseudouridine synthase activity
FCL45_RS19165	COG1329	Transcriptional regulator
FCL45_RS19170	COG0193	aminoacyl-tRNA hydrolase activity
FCL45_RS19175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FCL45_RS19180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FCL45_RS19190	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FCL45_RS19200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FCL45_RS19205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FCL45_RS19210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FCL45_RS19225	COG1918	ferrous iron import across plasma membrane
FCL45_RS19225	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FCL45_RS19235	COG1595	DNA-templated transcription, initiation
FCL45_RS19250	COG3977	Valine--pyruvate aminotransferase
FCL45_RS19260	COG0406	alpha-ribazole phosphatase activity
FCL45_RS19265	COG1192	Involved in chromosome partitioning
FCL45_RS19275	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FCL45_RS19290	COG2326	polyphosphate kinase activity
FCL45_RS19295	COG0653	protein targeting
FCL45_RS19305	COG0018	arginyl-trna synthetase
FCL45_RS19310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FCL45_RS19330	COG1797	cobyrinic acid a,c-diamide synthase activity
FCL45_RS19340	COG0556	nucleotide-excision repair
FCL45_RS19365	COG0426	domain, Protein
FCL45_RS19375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FCL45_RS19380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL45_RS19380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FCL45_RS19390	COG1773	rubredoxin
FCL45_RS19390	COG1592	Rubrerythrin
FCL45_RS19395	COG2226	methyltransferase
FCL45_RS19400	COG1151	hydroxylamine reductase activity
FCL45_RS19405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FCL45_RS19420	COG3045	CreA protein
FCL45_RS19465	COG3206	protein involved in exopolysaccharide biosynthesis
FCL45_RS19465	COG0489	protein tyrosine kinase activity
FCL45_RS19485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FCL45_RS19520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FCL45_RS19540	COG0604	alcohol dehydrogenase
FCL45_RS19540	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS19540	COG3321	synthase
FCL45_RS19545	COG0110	maltose O-acetyltransferase activity
FCL45_RS19580	COG1215	transferase activity, transferring glycosyl groups
FCL45_RS19600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FCL45_RS19605	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FCL45_RS19610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FCL45_RS19645	COG0367	asparagine synthase
FCL45_RS19680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FCL45_RS19685	COG0028	Belongs to the TPP enzyme family
FCL45_RS19690	COG0440	acetolactate synthase activity
FCL45_RS19695	COG0688	phosphatidylethanolamine metabolic process
FCL45_RS19710	COG1183	phosphatidylcholine synthase activity
FCL45_RS19715	COG0742	ribosomal rna small subunit methyltransferase
FCL45_RS19720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FCL45_RS19740	COG1100	Small GTP-binding protein
FCL45_RS19750	COG0084	hydrolase, TatD family'
FCL45_RS19760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FCL45_RS19785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FCL45_RS19785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FCL45_RS19790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FCL45_RS19795	COG0698	ribose 5-phosphate isomerase
FCL45_RS19800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FCL45_RS19810	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS19815	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FCL45_RS19820	COG2086	electron transfer activity
FCL45_RS19830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FCL45_RS19840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FCL45_RS19865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FCL45_RS19870	COG1127	ABC transporter
FCL45_RS19875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FCL45_RS19880	COG4239	(ABC) transporter, permease
FCL45_RS19885	COG4174	ABC transporter (Permease)
FCL45_RS19890	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FCL45_RS19905	COG4548	von Willebrand factor, type A
FCL45_RS19910	COG0714	Associated with various cellular activities
FCL45_RS19920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FCL45_RS19925	COG0228	four-way junction DNA binding
FCL45_RS19930	COG1837	Belongs to the UPF0109 family
FCL45_RS19935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FCL45_RS19940	COG0336	Belongs to the RNA methyltransferase TrmD family
FCL45_RS19945	COG4752	Belongs to the RNA methyltransferase TrmD family
FCL45_RS19950	COG0335	large ribosomal subunit rRNA binding
FCL45_RS19955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FCL45_RS19965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FCL45_RS19970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FCL45_RS19990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL45_RS20000	COG0438	transferase activity, transferring glycosyl groups
FCL45_RS20000	COG0297	glycogen (starch) synthase activity
FCL45_RS20025	COG1280	lysine exporter protein (LysE YggA)
FCL45_RS20030	COG0420	3'-5' exonuclease activity
FCL45_RS20035	COG0419	ATPase involved in DNA repair
FCL45_RS20050	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FCL45_RS20055	COG1342	Belongs to the UPF0251 family
FCL45_RS20070	COG5000	phosphorelay sensor kinase activity
FCL45_RS20075	COG2204	response regulator
FCL45_RS20080	COG0113	porphobilinogen synthase activity
FCL45_RS20090	COG0653	protein targeting
FCL45_RS20100	COG0596	Alpha beta hydrolase
FCL45_RS20105	COG1151	hydroxylamine reductase activity
FCL45_RS20135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL45_RS20160	COG0346	lactoylglutathione lyase activity
FCL45_RS20355	COG0285	dihydrofolate synthase activity
FCL45_RS20360	COG0210	DNA helicase
FCL45_RS20395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FCL45_RS20400	COG1013	pyruvate-flavodoxin oxidoreductase activity
FCL45_RS20400	COG0674	pyruvate-flavodoxin oxidoreductase activity
FCL45_RS20400	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FCL45_RS20400	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FCL45_RS20420	COG0446	pyridine nucleotide-disulphide oxidoreductase
FCL45_RS20425	COG0390	transport system, permease component
FCL45_RS20430	COG4619	ABC transporter
FCL45_RS20435	COG4191	Histidine kinase
FCL45_RS20440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL45_RS20455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FCL45_RS20460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FCL45_RS20465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FCL45_RS20470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FCL45_RS20475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FCL45_RS20480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FCL45_RS20495	COG0275	rRNA processing
FCL45_RS20500	COG2001	Belongs to the MraZ family
FCL45_RS20505	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FCL45_RS20510	COG2255	four-way junction helicase activity
FCL45_RS20515	COG0632	four-way junction helicase activity
FCL45_RS20520	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FCL45_RS20525	COG0217	transcriptional regulatory protein
FCL45_RS20530	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FCL45_RS20535	COG0617	tRNA 3'-terminal CCA addition
FCL45_RS20540	COG0668	transmembrane transport
FCL45_RS20550	COG0778	Nitroreductase
FCL45_RS20555	COG0679	Auxin Efflux Carrier
FCL45_RS20565	COG0497	DNA recombination
FCL45_RS20580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FCL45_RS20585	COG0038	chloride channel
FCL45_RS20615	COG0210	DNA helicase
FCL45_RS20645	COG2356	endonuclease I
FCL45_RS20650	COG4974	Belongs to the 'phage' integrase family
FCL45_RS20660	COG0517	IMP dehydrogenase activity
FCL45_RS20705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FCL45_RS20710	COG4983	Phage plasmid primase, P4 family domain protein
FCL45_RS20720	COG4974	Belongs to the 'phage' integrase family
FCL45_RS20725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FCL45_RS20735	COG0277	FAD linked oxidase domain protein
FCL45_RS20760	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FCL45_RS20765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FCL45_RS20780	COG1136	(ABC) transporter
FCL45_RS20780	COG0577	efflux transmembrane transporter activity
FCL45_RS20810	COG0746	molybdenum cofactor guanylyltransferase activity
FCL45_RS20815	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FCL45_RS20825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FCL45_RS20835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FCL45_RS20845	COG1032	radical SAM domain protein
FCL45_RS20855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FCL45_RS20860	COG0194	GDP metabolic process
FCL45_RS20865	COG2052	Domain of unknown function (DUF370)
FCL45_RS20870	COG1561	YicC-like family, N-terminal region
FCL45_RS20880	COG2885	chlorophyll binding
FCL45_RS20885	COG0058	SHG alpha-glucan phosphorylase activity
FCL45_RS20900	COG0735	belongs to the Fur family
FCL45_RS20905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FCL45_RS20910	COG1418	mRNA catabolic process
FCL45_RS20930	COG1051	belongs to the nudix hydrolase family
FCL45_RS20960	COG1295	ribonuclease BN
FCL45_RS20965	COG5002	protein histidine kinase activity
FCL45_RS20970	COG5002	protein histidine kinase activity
FCL45_RS20975	COG0745	RESPONSE REGULATOR receiver
FCL45_RS20980	COG0704	Plays a role in the regulation of phosphate uptake
FCL45_RS20985	COG0573	inorganic phosphate transmembrane transporter activity
FCL45_RS21000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FCL45_RS21005	COG3005	denitrification pathway
FCL45_RS21010	COG2204	response regulator
FCL45_RS21015	COG0440	acetolactate synthase activity
FCL45_RS21020	COG4895	conserved protein (DUF2196)
FCL45_RS21075	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FCL45_RS21085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FCL45_RS21095	COG0709	Synthesizes selenophosphate from selenide and ATP
FCL45_RS21100	COG0516	GMP reductase activity
FCL45_RS21105	COG1007	ATP synthesis coupled electron transport
FCL45_RS21110	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL45_RS21115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FCL45_RS21125	COG0839	Belongs to the complex I subunit 6 family
FCL45_RS21130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL45_RS21135	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FCL45_RS21140	COG1034	ATP synthesis coupled electron transport
FCL45_RS21155	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL45_RS21155	COG0649	NAD binding
FCL45_RS21160	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL45_RS21165	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL45_RS21170	COG0527	aspartate kinase activity
FCL45_RS21180	COG2951	lytic endotransglycosylase activity
FCL45_RS21225	COG2916	Histone family protein nucleoid-structuring protein H-NS
FCL45_RS21240	COG0745	RESPONSE REGULATOR receiver
FCL45_RS21255	COG2204	response regulator
FCL45_RS21260	COG0745	RESPONSE REGULATOR receiver
FCL45_RS21265	COG2204	response regulator
FCL45_RS21290	COG0501	Belongs to the peptidase M48B family
FCL45_RS21295	COG1307	EDD domain protein, DegV family
FCL45_RS21315	COG0667	Aldo Keto reductase
FCL45_RS21320	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
FCL45_RS21360	COG0454	-acetyltransferase
FCL45_RS21375	COG0058	SHG alpha-glucan phosphorylase activity
FCL45_RS21390	COG0588	phosphoglycerate mutase activity
FCL45_RS21405	COG2067	long-chain fatty acid transport protein
FCL45_RS21435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FCL45_RS21440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FCL45_RS21445	COG2022	thiamine diphosphate biosynthetic process
FCL45_RS21450	COG0352	thiamine-phosphate diphosphorylase activity
FCL45_RS21465	COG2261	transglycosylase associated protein
FCL45_RS21485	COG1733	regulation of RNA biosynthetic process
FCL45_RS21490	COG0243	molybdopterin cofactor binding
FCL45_RS21505	COG3239	Fatty acid desaturase
FCL45_RS21510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FCL45_RS21535	COG1486	melibiose metabolic process
FCL45_RS21540	COG1172	Belongs to the binding-protein-dependent transport system permease family
FCL45_RS21555	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FCL45_RS21560	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FCL45_RS21570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FCL45_RS21605	COG3385	transposase activity
FCL45_RS21655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FCL45_RS21660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FCL45_RS21670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FCL45_RS21685	COG0545	Peptidyl-prolyl cis-trans isomerase
FCL45_RS21700	COG0442	prolyl-tRNA aminoacylation
FCL45_RS21705	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FCL45_RS21710	COG1214	PFAM Peptidase M22, glycoprotease
FCL45_RS21715	COG0750	zinc metalloprotease
FCL45_RS21720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FCL45_RS21725	COG4589	Belongs to the CDS family
FCL45_RS21730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FCL45_RS21735	COG0233	cytoplasmic translational termination
FCL45_RS21740	COG0528	UMP kinase activity
FCL45_RS21745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FCL45_RS21750	COG0052	Belongs to the universal ribosomal protein uS2 family
FCL45_RS21760	COG0203	ribosomal protein L17
FCL45_RS21765	COG0202	RNA polymerase activity
FCL45_RS21770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FCL45_RS21775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FCL45_RS21780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FCL45_RS21785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FCL45_RS21790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FCL45_RS21805	COG0200	Binds to the 23S rRNA
FCL45_RS21810	COG1841	ribosomal large subunit assembly
FCL45_RS21815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FCL45_RS21820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FCL45_RS21825	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FCL45_RS21835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FCL45_RS21840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FCL45_RS21845	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FCL45_RS21850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FCL45_RS21855	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FCL45_RS21860	COG0255	Belongs to the universal ribosomal protein uL29 family
FCL45_RS21865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FCL45_RS21870	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FCL45_RS21875	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FCL45_RS21880	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FCL45_RS21885	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FCL45_RS21890	COG0089	rRNA binding
FCL45_RS21895	COG0088	Forms part of the polypeptide exit tunnel
FCL45_RS21900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FCL45_RS21905	COG0051	transcription antitermination factor activity, RNA binding
FCL45_RS21910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FCL45_RS21915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FCL45_RS21920	COG0049	tRNA binding
FCL45_RS21925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FCL45_RS21930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FCL45_RS21935	COG0085	RNA polymerase activity
FCL45_RS21940	COG0222	ribosome binding
FCL45_RS21945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FCL45_RS21950	COG0081	regulation of translation
FCL45_RS21955	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FCL45_RS21975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FCL45_RS21980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FCL45_RS22015	COG1233	COG1233 Phytoene dehydrogenase and related
FCL45_RS22030	COG1674	ftsk spoiiie
FCL45_RS22035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FCL45_RS22040	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FCL45_RS22045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FCL45_RS22045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FCL45_RS22090	COG0330	HflC and HflK could
FCL45_RS22105	COG0372	Belongs to the citrate synthase family
FCL45_RS22120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FCL45_RS22125	COG0772	Belongs to the SEDS family
FCL45_RS22130	COG0768	penicillin binding
FCL45_RS22160	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FCL45_RS22170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FCL45_RS22175	COG0557	exoribonuclease II activity
FCL45_RS22200	COG0205	6-phosphofructokinase activity
FCL45_RS22215	COG0542	response to heat
FCL45_RS22265	COG2433	Pfam Transposase IS66
FCL45_RS22280	COG1132	(ABC) transporter
FCL45_RS22285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FCL45_RS22290	COG0138	bifunctional purine biosynthesis protein purh
FCL45_RS22300	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FCL45_RS22310	COG0142	geranyltranstransferase activity
FCL45_RS22315	COG1199	ATP-dependent helicase activity
FCL45_RS22320	COG5002	protein histidine kinase activity
FCL45_RS22325	COG2814	Major facilitator Superfamily
FCL45_RS22350	COG0438	transferase activity, transferring glycosyl groups
FCL45_RS22370	COG0577	efflux transmembrane transporter activity
FCL45_RS22370	COG1136	(ABC) transporter
FCL45_RS22375	COG1136	(ABC) transporter
FCL45_RS22435	COG0805	protein transport
FCL45_RS22440	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FCL45_RS22445	COG0668	transmembrane transport
FCL45_RS22460	COG0450	alkyl hydroperoxide reductase
FCL45_RS22470	COG0437	4 iron, 4 sulfur cluster binding
FCL45_RS22500	COG4585	Histidine kinase
FCL45_RS22510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FCL45_RS22515	COG1181	Belongs to the D-alanine--D-alanine ligase family
FCL45_RS22520	COG0277	FAD linked oxidase domain protein
FCL45_RS22535	COG3620	sequence-specific DNA binding
FCL45_RS22535	COG0617	tRNA 3'-terminal CCA addition
FCL45_RS22535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FCL45_RS22540	COG1994	Peptidase M50
FCL45_RS22545	COG1022	Amp-dependent synthetase and ligase
FCL45_RS22550	COG1686	Belongs to the peptidase S11 family
FCL45_RS22555	COG0587	DNA-directed DNA polymerase activity
FCL45_RS22560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FCL45_RS22570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FCL45_RS22585	COG0159	tryptophan synthase activity
FCL45_RS22590	COG0133	tryptophan synthase activity
FCL45_RS22600	COG2204	response regulator
FCL45_RS22605	COG0372	Belongs to the citrate synthase family
FCL45_RS22645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FCL45_RS22670	COG0556	nucleotide-excision repair
FCL45_RS22680	COG3122	Protein conserved in bacteria
FCL45_RS22710	COG2894	cell division
FCL45_RS22735	COG2204	response regulator
FCL45_RS22745	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FCL45_RS22750	COG4181	ATPase activity
FCL45_RS22755	COG1132	(ABC) transporter
FCL45_RS22760	COG1132	(ABC) transporter
FCL45_RS22780	COG3706	GGDEF domain
FCL45_RS22785	COG3012	SEC-C Motif Domain Protein
FCL45_RS22790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FCL45_RS22805	COG1773	rubredoxin
FCL45_RS22835	COG2113	Glycine betaine
FCL45_RS22840	COG4176	ABC-type proline glycine betaine transport system permease component
FCL45_RS22865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FCL45_RS22870	COG2900	Belongs to the SlyX family
FCL45_RS22880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FCL45_RS22885	COG1280	lysine exporter protein (LysE YggA)
FCL45_RS22895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FCL45_RS22900	COG0508	dehydrogenase complex catalyzes the overall conversion of
FCL45_RS22920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FCL45_RS22930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FCL45_RS22935	COG1842	Phage shock protein A
FCL45_RS22950	COG0561	phosphatase activity
FCL45_RS22960	COG1047	Peptidyl-prolyl cis-trans
FCL45_RS22970	COG2321	neutral zinc metallopeptidase
FCL45_RS22975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FCL45_RS23010	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS23020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FCL45_RS23030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FCL45_RS23080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FCL45_RS23085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FCL45_RS23110	COG0716	FMN binding
FCL45_RS23125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL45_RS23130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FCL45_RS23145	COG0745	RESPONSE REGULATOR receiver
FCL45_RS23150	COG5002	protein histidine kinase activity
FCL45_RS23215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FCL45_RS23215	COG1328	CTP reductase activity
FCL45_RS23220	COG0602	queuosine metabolic process
FCL45_RS23250	COG1309	transcriptional regulator
FCL45_RS23255	COG2130	NADP-dependent
FCL45_RS23280	COG1278	Cold shock
FCL45_RS23290	COG0215	cysteine-tRNA ligase activity
FCL45_RS23315	COG0004	ammonium transporteR
FCL45_RS23320	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FCL45_RS23335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FCL45_RS23340	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FCL45_RS23345	COG1091	dTDP-4-dehydrorhamnose reductase activity
FCL45_RS23370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FCL45_RS23395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FCL45_RS23455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FCL45_RS23460	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FCL45_RS23465	COG1216	Glycosyl transferase, family 2
FCL45_RS23470	COG2076	Multidrug Resistance protein
FCL45_RS23475	COG1215	transferase activity, transferring glycosyl groups
FCL45_RS23480	COG0438	transferase activity, transferring glycosyl groups
FCL45_RS23490	COG0463	Glycosyl transferase, family 2
FCL45_RS23495	COG2246	polysaccharide biosynthetic process
FCL45_RS23505	COG0438	transferase activity, transferring glycosyl groups
FCL45_RS23510	COG1216	Glycosyl transferase, family 2
FCL45_RS23530	COG1215	transferase activity, transferring glycosyl groups
FCL45_RS23545	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FCL45_RS23585	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FCL45_RS23590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FCL45_RS23600	COG0706	membrane insertase activity
FCL45_RS23605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FCL45_RS23610	COG0594	ribonuclease P activity
FCL45_RS23615	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FCL45_RS23620	COG0500	methyltransferase
FCL45_RS23625	COG0445	tRNA wobble uridine modification
FCL45_RS23630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FCL45_RS23640	COG2197	response regulator
FCL45_RS23650	COG0659	secondary active sulfate transmembrane transporter activity
FCL45_RS23655	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FCL45_RS23660	COG1032	radical SAM domain protein
FCL45_RS23665	COG0489	protein tyrosine kinase activity
FCL45_RS23675	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FCL45_RS23680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FCL45_RS23690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FCL45_RS23700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FCL45_RS23705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FCL45_RS23710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FCL45_RS23715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FCL45_RS23720	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FCL45_RS23725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FCL45_RS23735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FCL45_RS23760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FCL45_RS23760	COG0574	Belongs to the PEP-utilizing enzyme family
FCL45_RS23770	COG0297	glycogen (starch) synthase activity
FCL45_RS23775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FCL45_RS23780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FCL45_RS23785	COG0432	Pfam Uncharacterised protein family UPF0047
FCL45_RS23795	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FCL45_RS23800	COG1187	pseudouridine synthase activity
FCL45_RS23805	COG0776	regulation of translation
FCL45_RS23810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL45_RS23820	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FCL45_RS23825	COG0356	it plays a direct role in the translocation of protons across the membrane
FCL45_RS23840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FCL45_RS23845	COG3118	belongs to the thioredoxin family
FCL45_RS23850	COG0492	ferredoxin-NADP+ reductase activity
FCL45_RS23855	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FCL45_RS23875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FCL45_RS23905	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FCL45_RS23910	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FCL45_RS23925	COG2221	Nitrite and sulphite reductase 4Fe-4S
FCL45_RS23930	COG2221	Nitrite and sulphite reductase 4Fe-4S
FCL45_RS23935	COG0166	Belongs to the GPI family
FCL45_RS23940	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FCL45_RS23945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FCL45_RS23945	COG0758	DNA mediated transformation
FCL45_RS23955	COG0358	DNA primase activity
FCL45_RS23970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FCL45_RS23975	COG0149	triose-phosphate isomerase activity
FCL45_RS23995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FCL45_RS23995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FCL45_RS24000	COG1774	PSP1 C-terminal conserved region
FCL45_RS24010	COG3481	metal-dependent phosphohydrolase, HD sub domain
FCL45_RS24015	COG0012	GTP binding
FCL45_RS24020	COG0402	S-adenosylhomocysteine deaminase activity
FCL45_RS24025	COG1028	Short-chain dehydrogenase reductase Sdr
FCL45_RS24035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FCL45_RS24040	COG0778	Nitroreductase
FCL45_RS24075	COG4659	FMN binding
FCL45_RS24105	COG1053	succinate dehydrogenase
FCL45_RS24115	COG2909	trisaccharide binding
FCL45_RS24145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FCL45_RS24155	COG3830	Belongs to the UPF0237 family
FCL45_RS24160	COG2848	UPF0210 protein
FCL45_RS24165	COG0589	response to stress
FCL45_RS24185	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FCL45_RS24200	COG0745	RESPONSE REGULATOR receiver
FCL45_RS24210	COG1575	Belongs to the MenA family. Type 1 subfamily
FCL45_RS24220	COG1116	anion transmembrane transporter activity
FCL45_RS24230	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FCL45_RS24245	COG3022	response to hydroperoxide
FCL45_RS24265	COG3259	Nickel-dependent hydrogenase
FCL45_RS24280	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FCL45_RS24290	COG0326	Molecular chaperone. Has ATPase activity