locus-tag	class	description
FCL46_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FCL46_RS00020	COG0326	Molecular chaperone. Has ATPase activity
FCL46_RS00030	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FCL46_RS00040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL46_RS00045	COG3259	Nickel-dependent hydrogenase
FCL46_RS00060	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FCL46_RS00065	COG3022	response to hydroperoxide
FCL46_RS00080	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FCL46_RS00090	COG1116	anion transmembrane transporter activity
FCL46_RS00100	COG1575	Belongs to the MenA family. Type 1 subfamily
FCL46_RS00110	COG0745	RESPONSE REGULATOR receiver
FCL46_RS00130	COG2848	UPF0210 protein
FCL46_RS00135	COG3830	Belongs to the UPF0237 family
FCL46_RS00145	COG5002	protein histidine kinase activity
FCL46_RS00145	COG2205	protein histidine kinase activity
FCL46_RS00145	COG0784	Response regulator, receiver
FCL46_RS00150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FCL46_RS00160	COG0402	S-adenosylhomocysteine deaminase activity
FCL46_RS00165	COG0012	GTP binding
FCL46_RS00170	COG3481	metal-dependent phosphohydrolase, HD sub domain
FCL46_RS00175	COG0470	DNA polymerase III
FCL46_RS00180	COG1774	PSP1 C-terminal conserved region
FCL46_RS00185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FCL46_RS00185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FCL46_RS00200	COG1872	DUF167
FCL46_RS00205	COG0149	triose-phosphate isomerase activity
FCL46_RS00210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FCL46_RS00215	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FCL46_RS00220	COG1639	'signal transduction protein
FCL46_RS00225	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FCL46_RS00225	COG2199	diguanylate cyclase activity
FCL46_RS00235	COG0358	DNA primase activity
FCL46_RS00240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FCL46_RS00245	COG0758	DNA mediated transformation
FCL46_RS00245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FCL46_RS00250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FCL46_RS00255	COG0166	Belongs to the GPI family
FCL46_RS00260	COG2221	Nitrite and sulphite reductase 4Fe-4S
FCL46_RS00265	COG2221	Nitrite and sulphite reductase 4Fe-4S
FCL46_RS00275	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FCL46_RS00275	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FCL46_RS00280	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FCL46_RS00285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FCL46_RS00315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FCL46_RS00320	COG1691	(AIR) carboxylase
FCL46_RS00340	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FCL46_RS00345	COG0492	ferredoxin-NADP+ reductase activity
FCL46_RS00350	COG3118	belongs to the thioredoxin family
FCL46_RS00355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FCL46_RS00370	COG0356	it plays a direct role in the translocation of protons across the membrane
FCL46_RS00375	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FCL46_RS00380	COG0813	purine-nucleoside phosphorylase activity
FCL46_RS00385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL46_RS00390	COG0776	regulation of translation
FCL46_RS00395	COG1187	pseudouridine synthase activity
FCL46_RS00400	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FCL46_RS00410	COG0432	Pfam Uncharacterised protein family UPF0047
FCL46_RS00415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FCL46_RS00430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FCL46_RS00430	COG0574	Belongs to the PEP-utilizing enzyme family
FCL46_RS00460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FCL46_RS00470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FCL46_RS00475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FCL46_RS00480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FCL46_RS00485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FCL46_RS00490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FCL46_RS00495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FCL46_RS00500	COG0860	N-Acetylmuramoyl-L-alanine amidase
FCL46_RS00505	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FCL46_RS00515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FCL46_RS00530	COG0489	protein tyrosine kinase activity
FCL46_RS00535	COG1032	radical SAM domain protein
FCL46_RS00545	COG0659	secondary active sulfate transmembrane transporter activity
FCL46_RS00555	COG2197	response regulator
FCL46_RS00565	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FCL46_RS00570	COG0445	tRNA wobble uridine modification
FCL46_RS00575	COG2890	protein-(glutamine-N5) methyltransferase activity
FCL46_RS00580	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FCL46_RS00585	COG0594	ribonuclease P activity
FCL46_RS00590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FCL46_RS00595	COG0706	membrane insertase activity
FCL46_RS00605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FCL46_RS00610	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FCL46_RS00645	COG0463	Glycosyl transferase, family 2
FCL46_RS00660	COG0297	glycogen (starch) synthase activity
FCL46_RS00665	COG0297	glycogen (starch) synthase activity
FCL46_RS00665	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS00710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FCL46_RS00730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FCL46_RS00755	COG1091	dTDP-4-dehydrorhamnose reductase activity
FCL46_RS00760	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FCL46_RS00765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FCL46_RS00770	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FCL46_RS00770	COG0662	Cupin 2, conserved barrel domain protein
FCL46_RS00780	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FCL46_RS00785	COG0004	ammonium transporteR
FCL46_RS00810	COG0215	cysteine-tRNA ligase activity
FCL46_RS00830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL46_RS00870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FCL46_RS00930	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS00960	COG0297	glycogen (starch) synthase activity
FCL46_RS00960	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS00965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FCL46_RS00980	COG3206	protein involved in exopolysaccharide biosynthesis
FCL46_RS00980	COG0489	protein tyrosine kinase activity
FCL46_RS01020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FCL46_RS01025	COG2046	Belongs to the sulfate adenylyltransferase family
FCL46_RS01025	COG0529	Catalyzes the synthesis of activated sulfate
FCL46_RS01030	COG1793	dna ligase
FCL46_RS01050	COG0561	phosphatase activity
FCL46_RS01065	COG1842	Phage shock protein A
FCL46_RS01070	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FCL46_RS01090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FCL46_RS01110	COG0508	dehydrogenase complex catalyzes the overall conversion of
FCL46_RS01115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FCL46_RS01120	COG0210	DNA helicase
FCL46_RS01125	COG1280	lysine exporter protein (LysE YggA)
FCL46_RS01130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FCL46_RS01150	COG2900	Belongs to the SlyX family
FCL46_RS01170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FCL46_RS01205	COG3239	Fatty acid desaturase
FCL46_RS01220	COG1773	rubredoxin
FCL46_RS01225	COG0006	proline dipeptidase activity
FCL46_RS01230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FCL46_RS01235	COG3012	SEC-C Motif Domain Protein
FCL46_RS01245	COG3706	GGDEF domain
FCL46_RS01260	COG3385	transposase activity
FCL46_RS01275	COG1132	(ABC) transporter
FCL46_RS01280	COG1132	(ABC) transporter
FCL46_RS01285	COG1136	(ABC) transporter
FCL46_RS01285	COG0577	efflux transmembrane transporter activity
FCL46_RS01340	COG0076	glutamate decarboxylase activity
FCL46_RS01345	COG3122	Protein conserved in bacteria
FCL46_RS01375	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FCL46_RS01410	COG4657	Part of a membrane complex involved in electron transport
FCL46_RS01415	COG4660	Part of a membrane complex involved in electron transport
FCL46_RS01425	COG4658	electron transport chain
FCL46_RS01460	COG0737	Belongs to the 5'-nucleotidase family
FCL46_RS01485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FCL46_RS01495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FCL46_RS01500	COG0587	DNA-directed DNA polymerase activity
FCL46_RS01505	COG1686	Belongs to the peptidase S11 family
FCL46_RS01510	COG1022	Amp-dependent synthetase and ligase
FCL46_RS01520	COG1994	Peptidase M50
FCL46_RS01525	COG0617	tRNA 3'-terminal CCA addition
FCL46_RS01525	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FCL46_RS01525	COG3620	sequence-specific DNA binding
FCL46_RS01530	COG4974	Belongs to the 'phage' integrase family
FCL46_RS01540	COG0277	FAD linked oxidase domain protein
FCL46_RS01545	COG1181	Belongs to the D-alanine--D-alanine ligase family
FCL46_RS01550	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FCL46_RS01570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL46_RS01590	COG0437	4 iron, 4 sulfur cluster binding
FCL46_RS01600	COG0450	alkyl hydroperoxide reductase
FCL46_RS01615	COG0668	transmembrane transport
FCL46_RS01625	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FCL46_RS01630	COG0805	protein transport
FCL46_RS01655	COG1573	uracil-dna glycosylase
FCL46_RS01680	COG1132	(ABC) transporter
FCL46_RS01700	COG1136	(ABC) transporter
FCL46_RS01705	COG0577	efflux transmembrane transporter activity
FCL46_RS01725	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS01750	COG2814	Major facilitator Superfamily
FCL46_RS01755	COG4191	Histidine kinase
FCL46_RS01760	COG1199	ATP-dependent helicase activity
FCL46_RS01765	COG0142	geranyltranstransferase activity
FCL46_RS01770	COG0673	inositol 2-dehydrogenase activity
FCL46_RS01785	COG0138	bifunctional purine biosynthesis protein purh
FCL46_RS01790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FCL46_RS01795	COG1132	(ABC) transporter
FCL46_RS01835	COG0542	response to heat
FCL46_RS01850	COG0205	6-phosphofructokinase activity
FCL46_RS01860	COG1749	Flagellar hook protein flgE
FCL46_RS01870	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FCL46_RS01880	COG0557	exoribonuclease II activity
FCL46_RS01885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FCL46_RS01895	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FCL46_RS01920	COG1792	Involved in formation and maintenance of cell shape
FCL46_RS01935	COG0772	Belongs to the SEDS family
FCL46_RS01940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FCL46_RS01960	COG0352	thiamine-phosphate diphosphorylase activity
FCL46_RS02020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FCL46_RS02020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FCL46_RS02025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FCL46_RS02030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FCL46_RS02035	COG1674	ftsk spoiiie
FCL46_RS02050	COG1233	COG1233 Phytoene dehydrogenase and related
FCL46_RS02085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FCL46_RS02090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FCL46_RS02110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FCL46_RS02115	COG0081	regulation of translation
FCL46_RS02120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FCL46_RS02125	COG0222	ribosome binding
FCL46_RS02130	COG0085	RNA polymerase activity
FCL46_RS02135	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FCL46_RS02140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FCL46_RS02145	COG0049	tRNA binding
FCL46_RS02150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FCL46_RS02155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FCL46_RS02160	COG0051	transcription antitermination factor activity, RNA binding
FCL46_RS02165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FCL46_RS02170	COG0088	Forms part of the polypeptide exit tunnel
FCL46_RS02175	COG0089	rRNA binding
FCL46_RS02180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FCL46_RS02185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FCL46_RS02190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FCL46_RS02195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FCL46_RS02200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FCL46_RS02205	COG0255	Belongs to the universal ribosomal protein uL29 family
FCL46_RS02210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FCL46_RS02215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FCL46_RS02220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FCL46_RS02225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FCL46_RS02230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FCL46_RS02240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FCL46_RS02245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FCL46_RS02250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FCL46_RS02255	COG1841	ribosomal large subunit assembly
FCL46_RS02260	COG0200	Binds to the 23S rRNA
FCL46_RS02265	COG0201	protein transport
FCL46_RS02275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FCL46_RS02280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FCL46_RS02285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FCL46_RS02290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FCL46_RS02295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FCL46_RS02300	COG0202	RNA polymerase activity
FCL46_RS02305	COG0203	ribosomal protein L17
FCL46_RS02315	COG0052	Belongs to the universal ribosomal protein uS2 family
FCL46_RS02320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FCL46_RS02325	COG0528	UMP kinase activity
FCL46_RS02330	COG0233	cytoplasmic translational termination
FCL46_RS02335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FCL46_RS02340	COG4589	Belongs to the CDS family
FCL46_RS02345	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FCL46_RS02350	COG0750	zinc metalloprotease
FCL46_RS02355	COG1214	PFAM Peptidase M22, glycoprotease
FCL46_RS02360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FCL46_RS02365	COG0442	prolyl-tRNA aminoacylation
FCL46_RS02390	COG0840	transmembrane signaling receptor activity
FCL46_RS02395	COG0545	Peptidyl-prolyl cis-trans isomerase
FCL46_RS02410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FCL46_RS02420	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FCL46_RS02425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FCL46_RS02485	COG1278	Cold shock
FCL46_RS02500	COG2207	Transcriptional regulator
FCL46_RS02505	COG1979	alcohol dehydrogenase
FCL46_RS02515	COG0405	Gamma-glutamyltransferase
FCL46_RS02520	COG4191	Histidine kinase
FCL46_RS02525	COG0501	Belongs to the peptidase M48B family
FCL46_RS02570	COG2918	glutathione biosynthetic process
FCL46_RS02575	COG0346	lactoylglutathione lyase activity
FCL46_RS02590	COG4251	negative regulation of phosphorylation
FCL46_RS02595	COG0745	RESPONSE REGULATOR receiver
FCL46_RS02610	COG0398	Pfam SNARE associated Golgi protein
FCL46_RS02670	COG0406	alpha-ribazole phosphatase activity
FCL46_RS02685	COG0716	FMN binding
FCL46_RS02695	COG1704	LemA family
FCL46_RS02720	COG0735	belongs to the Fur family
FCL46_RS02725	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FCL46_RS02735	COG1733	regulation of RNA biosynthetic process
FCL46_RS02755	COG0556	nucleotide-excision repair
FCL46_RS02805	COG2951	lytic endotransglycosylase activity
FCL46_RS02810	COG2885	chlorophyll binding
FCL46_RS02820	COG0527	aspartate kinase activity
FCL46_RS02830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL46_RS02835	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL46_RS02840	COG0649	NAD binding
FCL46_RS02840	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL46_RS02860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FCL46_RS02865	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL46_RS02880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FCL46_RS02885	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL46_RS02890	COG1007	ATP synthesis coupled electron transport
FCL46_RS02905	COG2703	oxygen carrier activity
FCL46_RS02915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FCL46_RS02920	COG0363	glucosamine-6-phosphate deaminase activity
FCL46_RS02925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FCL46_RS02935	COG0437	4 iron, 4 sulfur cluster binding
FCL46_RS02980	COG4895	conserved protein (DUF2196)
FCL46_RS02990	COG0393	Putative heavy-metal-binding
FCL46_RS03005	COG1620	l-lactate permease
FCL46_RS03010	COG0277	FAD linked oxidase domain protein
FCL46_RS03015	COG0247	lactate metabolic process
FCL46_RS03045	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FCL46_RS03055	COG2205	protein histidine kinase activity
FCL46_RS03055	COG0784	Response regulator, receiver
FCL46_RS03055	COG5002	protein histidine kinase activity
FCL46_RS03095	COG2204	response regulator
FCL46_RS03115	COG0384	phenazine biosynthesis protein PhzF
FCL46_RS03140	COG3437	response regulator, receiver
FCL46_RS03145	COG0784	Response regulator, receiver
FCL46_RS03145	COG2198	Histidine kinase
FCL46_RS03145	COG2205	protein histidine kinase activity
FCL46_RS03155	COG2354	Protein conserved in bacteria
FCL46_RS03170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FCL46_RS03185	COG2204	response regulator
FCL46_RS03200	COG2204	response regulator
FCL46_RS03205	COG0745	RESPONSE REGULATOR receiver
FCL46_RS03210	COG2204	response regulator
FCL46_RS03215	COG4566	intracellular signal transduction
FCL46_RS03230	COG0501	Belongs to the peptidase M48B family
FCL46_RS03235	COG0840	transmembrane signaling receptor activity
FCL46_RS03285	COG3335	DDE superfamily endonuclease
FCL46_RS03290	COG1234	tRNA 3'-trailer cleavage
FCL46_RS03300	COG2239	Acts as a magnesium transporter
FCL46_RS03305	COG2234	aminopeptidase activity
FCL46_RS03315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FCL46_RS03335	COG0189	ligase activity
FCL46_RS03455	COG0277	FAD linked oxidase domain protein
FCL46_RS03460	COG2208	phosphoserine phosphatase activity
FCL46_RS03475	COG0840	transmembrane signaling receptor activity
FCL46_RS03480	COG3604	Transcriptional regulator
FCL46_RS03515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FCL46_RS03555	COG4106	trans-aconitate 2-methyltransferase activity
FCL46_RS03565	COG3119	arylsulfatase activity
FCL46_RS03595	COG0784	Response regulator, receiver
FCL46_RS03595	COG5002	protein histidine kinase activity
FCL46_RS03610	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FCL46_RS03610	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FCL46_RS03620	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL46_RS03655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FCL46_RS03670	COG0573	inorganic phosphate transmembrane transporter activity
FCL46_RS03675	COG0704	Plays a role in the regulation of phosphate uptake
FCL46_RS03680	COG0745	RESPONSE REGULATOR receiver
FCL46_RS03685	COG5002	protein histidine kinase activity
FCL46_RS03690	COG2205	protein histidine kinase activity
FCL46_RS03690	COG4191	Histidine kinase
FCL46_RS03690	COG0745	RESPONSE REGULATOR receiver
FCL46_RS03700	COG2205	protein histidine kinase activity
FCL46_RS03700	COG3437	response regulator, receiver
FCL46_RS03700	COG3850	Histidine kinase
FCL46_RS03700	COG4999	Histidine kinase
FCL46_RS03715	COG1051	belongs to the nudix hydrolase family
FCL46_RS03735	COG1418	mRNA catabolic process
FCL46_RS03740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FCL46_RS03745	COG0735	belongs to the Fur family
FCL46_RS03765	COG2885	chlorophyll binding
FCL46_RS03775	COG1561	YicC-like family, N-terminal region
FCL46_RS03780	COG2052	Domain of unknown function (DUF370)
FCL46_RS03785	COG0194	GDP metabolic process
FCL46_RS03790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FCL46_RS03815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FCL46_RS03825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FCL46_RS03835	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FCL46_RS03845	COG2205	protein histidine kinase activity
FCL46_RS03880	COG0577	efflux transmembrane transporter activity
FCL46_RS03880	COG1136	(ABC) transporter
FCL46_RS03895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FCL46_RS03900	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FCL46_RS03935	COG0784	Response regulator, receiver
FCL46_RS03935	COG2205	protein histidine kinase activity
FCL46_RS03940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FCL46_RS04010	COG0305	Participates in initiation and elongation during chromosome replication
FCL46_RS04020	COG1484	DNA-dependent DNA replication
FCL46_RS04025	COG4584	PFAM Integrase catalytic
FCL46_RS04050	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FCL46_RS04055	COG0038	chloride channel
FCL46_RS04060	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FCL46_RS04070	COG1321	iron dependent repressor
FCL46_RS04075	COG0497	DNA recombination
FCL46_RS04090	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS04100	COG0668	transmembrane transport
FCL46_RS04105	COG0617	tRNA 3'-terminal CCA addition
FCL46_RS04110	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FCL46_RS04115	COG0217	transcriptional regulatory protein
FCL46_RS04125	COG0632	four-way junction helicase activity
FCL46_RS04130	COG2255	four-way junction helicase activity
FCL46_RS04135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FCL46_RS04140	COG2001	Belongs to the MraZ family
FCL46_RS04145	COG0275	rRNA processing
FCL46_RS04155	COG0768	penicillin binding
FCL46_RS04160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FCL46_RS04165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FCL46_RS04170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FCL46_RS04175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FCL46_RS04180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FCL46_RS04185	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FCL46_RS04200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL46_RS04205	COG4191	Histidine kinase
FCL46_RS04210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FCL46_RS04215	COG0390	transport system, permease component
FCL46_RS04220	COG0446	pyridine nucleotide-disulphide oxidoreductase
FCL46_RS04245	COG0674	pyruvate-flavodoxin oxidoreductase activity
FCL46_RS04245	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FCL46_RS04245	COG1013	pyruvate-flavodoxin oxidoreductase activity
FCL46_RS04245	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FCL46_RS04275	COG1472	Belongs to the glycosyl hydrolase 3 family
FCL46_RS04280	COG3706	GGDEF domain
FCL46_RS04295	COG0285	dihydrofolate synthase activity
FCL46_RS04375	COG0066	3-isopropylmalate dehydratase activity
FCL46_RS04380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FCL46_RS04395	COG2945	thiolester hydrolase activity
FCL46_RS04400	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FCL46_RS04410	COG4191	Histidine kinase
FCL46_RS04410	COG0784	Response regulator, receiver
FCL46_RS04450	COG0729	surface antigen
FCL46_RS04465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FCL46_RS04470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FCL46_RS04470	COG0045	succinate-CoA ligase (ADP-forming) activity
FCL46_RS04470	COG1042	CoA-binding domain protein
FCL46_RS04475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FCL46_RS04490	COG0668	transmembrane transport
FCL46_RS04505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL46_RS04510	COG2204	response regulator
FCL46_RS04520	COG3829	transcription factor binding
FCL46_RS04520	COG3290	protein histidine kinase activity
FCL46_RS04525	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FCL46_RS04530	COG2414	aldehyde ferredoxin oxidoreductase
FCL46_RS04555	COG0517	IMP dehydrogenase activity
FCL46_RS04590	COG3119	arylsulfatase activity
FCL46_RS04605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FCL46_RS04625	COG1803	Methylglyoxal synthase
FCL46_RS04635	COG2226	methyltransferase
FCL46_RS04645	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FCL46_RS04660	COG0356	it plays a direct role in the translocation of protons across the membrane
FCL46_RS04670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FCL46_RS04670	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FCL46_RS04675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FCL46_RS04680	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FCL46_RS04690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL46_RS04690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL46_RS04695	COG1131	(ABC) transporter
FCL46_RS04700	COG0842	Transport permease protein
FCL46_RS04705	COG0842	Transport permease protein
FCL46_RS04725	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FCL46_RS04730	COG2165	general secretion pathway protein
FCL46_RS04735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FCL46_RS04755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FCL46_RS04790	COG0653	protein targeting
FCL46_RS04805	COG0113	porphobilinogen synthase activity
FCL46_RS04810	COG2204	response regulator
FCL46_RS04815	COG5000	phosphorelay sensor kinase activity
FCL46_RS04830	COG1342	Belongs to the UPF0251 family
FCL46_RS04835	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FCL46_RS04850	COG0419	ATPase involved in DNA repair
FCL46_RS04855	COG0420	3'-5' exonuclease activity
FCL46_RS04860	COG1280	lysine exporter protein (LysE YggA)
FCL46_RS04890	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS04900	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
FCL46_RS04925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FCL46_RS04930	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FCL46_RS04935	COG0792	nuclease activity
FCL46_RS04940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FCL46_RS04945	COG0335	large ribosomal subunit rRNA binding
FCL46_RS04950	COG4752	Belongs to the RNA methyltransferase TrmD family
FCL46_RS04955	COG0336	Belongs to the RNA methyltransferase TrmD family
FCL46_RS04960	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FCL46_RS04965	COG1837	Belongs to the UPF0109 family
FCL46_RS04970	COG0228	four-way junction DNA binding
FCL46_RS04975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FCL46_RS04980	COG0714	Associated with various cellular activities
FCL46_RS04985	COG4548	von Willebrand factor, type A
FCL46_RS04995	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FCL46_RS05000	COG4174	ABC transporter (Permease)
FCL46_RS05005	COG4239	(ABC) transporter, permease
FCL46_RS05010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FCL46_RS05045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FCL46_RS05055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FCL46_RS05065	COG2086	electron transfer activity
FCL46_RS05070	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FCL46_RS05080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FCL46_RS05085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FCL46_RS05090	COG0698	ribose 5-phosphate isomerase
FCL46_RS05095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FCL46_RS05100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FCL46_RS05100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FCL46_RS05110	COG0776	regulation of translation
FCL46_RS05125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FCL46_RS05130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FCL46_RS05135	COG0084	hydrolase, TatD family'
FCL46_RS05145	COG1100	Small GTP-binding protein
FCL46_RS05165	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FCL46_RS05170	COG0742	ribosomal rna small subunit methyltransferase
FCL46_RS05175	COG0688	phosphatidylethanolamine metabolic process
FCL46_RS05180	COG0440	acetolactate synthase activity
FCL46_RS05185	COG0028	Belongs to the TPP enzyme family
FCL46_RS05190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FCL46_RS05205	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FCL46_RS05215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FCL46_RS05245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FCL46_RS05255	COG2801	Transposase and inactivated derivatives
FCL46_RS05270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FCL46_RS05275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FCL46_RS05280	COG1088	dTDP-glucose 4,6-dehydratase activity
FCL46_RS05290	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FCL46_RS05310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FCL46_RS05315	COG2244	polysaccharide biosynthetic process
FCL46_RS05325	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS05335	COG0110	maltose O-acetyltransferase activity
FCL46_RS05345	COG3754	Rhamnan synthesis protein F
FCL46_RS05355	COG1216	Glycosyl transferase, family 2
FCL46_RS05360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FCL46_RS05465	COG3045	CreA protein
FCL46_RS05485	COG1151	hydroxylamine reductase activity
FCL46_RS05490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FCL46_RS05495	COG1773	rubredoxin
FCL46_RS05495	COG1592	Rubrerythrin
FCL46_RS05500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL46_RS05500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FCL46_RS05510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FCL46_RS05520	COG0426	domain, Protein
FCL46_RS05540	COG0328	RNA-DNA hybrid ribonuclease activity
FCL46_RS05545	COG0556	nucleotide-excision repair
FCL46_RS05555	COG1797	cobyrinic acid a,c-diamide synthase activity
FCL46_RS05575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FCL46_RS05580	COG0018	arginyl-trna synthetase
FCL46_RS05590	COG0653	protein targeting
FCL46_RS05595	COG0653	protein targeting
FCL46_RS05600	COG2326	polyphosphate kinase activity
FCL46_RS05605	COG2326	polyphosphate kinase activity
FCL46_RS05615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FCL46_RS05625	COG1192	Involved in chromosome partitioning
FCL46_RS05650	COG3977	Valine--pyruvate aminotransferase
FCL46_RS05665	COG1473	amidohydrolase
FCL46_RS05670	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FCL46_RS05675	COG0405	Gamma-glutamyltransferase
FCL46_RS05680	COG1595	DNA-templated transcription, initiation
FCL46_RS05690	COG1918	ferrous iron import across plasma membrane
FCL46_RS05690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FCL46_RS05715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FCL46_RS05720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FCL46_RS05725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FCL46_RS05735	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FCL46_RS05745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FCL46_RS05750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FCL46_RS05755	COG0193	aminoacyl-tRNA hydrolase activity
FCL46_RS05760	COG1329	Transcriptional regulator
FCL46_RS05765	COG0564	pseudouridine synthase activity
FCL46_RS05770	COG0237	dephospho-CoA kinase activity
FCL46_RS05775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FCL46_RS05780	COG0254	rRNA binding
FCL46_RS05785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FCL46_RS05790	COG2890	protein-(glutamine-N5) methyltransferase activity
FCL46_RS05795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FCL46_RS05800	COG0469	pyruvate kinase activity
FCL46_RS05810	COG3852	Histidine kinase
FCL46_RS05815	COG2204	response regulator
FCL46_RS05820	COG2827	Endonuclease containing a URI domain
FCL46_RS05830	COG0805	protein transport
FCL46_RS05855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FCL46_RS05865	COG1722	exodeoxyribonuclease VII activity
FCL46_RS05870	COG4974	Belongs to the 'phage' integrase family
FCL46_RS05875	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FCL46_RS05880	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FCL46_RS05900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FCL46_RS05905	COG0733	neurotransmitter:sodium symporter activity
FCL46_RS05915	COG2081	HI0933 family
FCL46_RS05930	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
FCL46_RS05935	COG0348	domain, Protein
FCL46_RS05945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FCL46_RS05950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FCL46_RS05955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FCL46_RS05960	COG0357	Ribosomal RNA small subunit methyltransferase G
FCL46_RS05965	COG0473	3-isopropylmalate dehydrogenase activity
FCL46_RS05970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FCL46_RS05975	COG2204	response regulator
FCL46_RS06005	COG1136	(ABC) transporter
FCL46_RS06015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FCL46_RS06020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FCL46_RS06030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FCL46_RS06035	COG0443	Heat shock 70 kDa protein
FCL46_RS06050	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FCL46_RS06065	COG2814	Major facilitator Superfamily
FCL46_RS06085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FCL46_RS06095	COG1519	Transferase
FCL46_RS06110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FCL46_RS06120	COG1028	Short-chain dehydrogenase reductase Sdr
FCL46_RS06125	COG0424	maF-like protein
FCL46_RS06165	COG5002	protein histidine kinase activity
FCL46_RS06165	COG2205	protein histidine kinase activity
FCL46_RS06165	COG0784	Response regulator, receiver
FCL46_RS06175	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FCL46_RS06185	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FCL46_RS06190	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FCL46_RS06195	COG1278	Cold shock
FCL46_RS06200	COG0724	RNA recognition motif
FCL46_RS06205	COG0306	phosphate transporter
FCL46_RS06210	COG1392	Phosphate transport regulator
FCL46_RS06220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FCL46_RS06230	COG0493	'glutamate synthase
FCL46_RS06250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FCL46_RS06255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FCL46_RS06260	COG0402	S-adenosylhomocysteine deaminase activity
FCL46_RS06275	COG0799	negative regulation of ribosome biogenesis
FCL46_RS06280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FCL46_RS06280	COG0551	DNA topoisomerase type I activity
FCL46_RS06285	COG0779	Required for maturation of 30S ribosomal subunits
FCL46_RS06290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FCL46_RS06290	COG0195	Participates in both transcription termination and antitermination
FCL46_RS06300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FCL46_RS06300	COG3064	Membrane
FCL46_RS06305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FCL46_RS06315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FCL46_RS06320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FCL46_RS06325	COG1185	polyribonucleotide nucleotidyltransferase activity
FCL46_RS06330	COG0756	dUTP diphosphatase activity
FCL46_RS06335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FCL46_RS06340	COG1534	Rna-binding protein
FCL46_RS06350	COG1388	LysM domain
FCL46_RS06350	COG3942	CHAP domain
FCL46_RS06365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FCL46_RS06390	COG0840	transmembrane signaling receptor activity
FCL46_RS06395	COG2205	protein histidine kinase activity
FCL46_RS06395	COG0784	Response regulator, receiver
FCL46_RS06405	COG1213	nucleotidyl transferase
FCL46_RS06410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FCL46_RS06435	COG2264	protein methyltransferase activity
FCL46_RS06490	COG0437	4 iron, 4 sulfur cluster binding
FCL46_RS06495	COG0243	molybdopterin cofactor binding
FCL46_RS06500	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FCL46_RS06505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FCL46_RS06510	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FCL46_RS06515	COG2205	protein histidine kinase activity
FCL46_RS06520	COG0011	TIGRFAM Protein of
FCL46_RS06530	COG4106	trans-aconitate 2-methyltransferase activity
FCL46_RS06550	COG0252	asparaginase activity
FCL46_RS06555	COG1115	amino acid carrier protein
FCL46_RS06565	COG1178	ABC-type Fe3 transport system permease component
FCL46_RS06570	COG3842	ATPase activity
FCL46_RS06575	COG0084	hydrolase, TatD family'
FCL46_RS06590	COG0243	molybdopterin cofactor binding
FCL46_RS06675	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FCL46_RS06695	COG2996	Protein conserved in bacteria
FCL46_RS06705	COG3706	GGDEF domain
FCL46_RS06705	COG2203	Gaf domain
FCL46_RS06705	COG4251	negative regulation of phosphorylation
FCL46_RS06705	COG5001	Diguanylate cyclase
FCL46_RS06720	COG0686	Belongs to the AlaDH PNT family
FCL46_RS06725	COG1115	amino acid carrier protein
FCL46_RS06735	COG0583	DNA-binding transcription factor activity
FCL46_RS06745	COG2095	MarC family integral membrane protein
FCL46_RS06750	COG0494	nUDIX hydrolase
FCL46_RS06760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FCL46_RS06765	COG0456	acetyltransferase
FCL46_RS06790	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FCL46_RS06805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS06815	COG1115	amino acid carrier protein
FCL46_RS06845	COG0501	Belongs to the peptidase M48B family
FCL46_RS06850	COG1007	ATP synthesis coupled electron transport
FCL46_RS06870	COG0651	ATP synthesis coupled electron transport
FCL46_RS06875	COG0713	ATP synthesis coupled electron transport
FCL46_RS06880	COG0839	Belongs to the complex I subunit 6 family
FCL46_RS06885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL46_RS06890	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FCL46_RS06895	COG0649	NAD binding
FCL46_RS06900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL46_RS06905	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL46_RS06910	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL46_RS06915	COG0583	DNA-binding transcription factor activity
FCL46_RS06920	COG0101	tRNA pseudouridine synthase activity
FCL46_RS06925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FCL46_RS06930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FCL46_RS06935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FCL46_RS06945	COG0131	Imidazoleglycerol-phosphate dehydratase
FCL46_RS06965	COG0017	Asparaginyl-tRNA synthetase
FCL46_RS06975	COG2226	methyltransferase
FCL46_RS06980	COG1022	Amp-dependent synthetase and ligase
FCL46_RS07005	COG0589	response to stress
FCL46_RS07020	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FCL46_RS07025	COG1074	ATP-dependent DNA helicase activity
FCL46_RS07030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FCL46_RS07035	COG0277	FAD linked oxidase domain protein
FCL46_RS07045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FCL46_RS07070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FCL46_RS07075	COG0023	Translation Initiation Factor
FCL46_RS07140	COG1216	Glycosyl transferase, family 2
FCL46_RS07170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS07170	COG4191	Histidine kinase
FCL46_RS07185	COG1366	Belongs to the anti-sigma-factor antagonist family
FCL46_RS07195	COG1366	Belongs to the anti-sigma-factor antagonist family
FCL46_RS07200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FCL46_RS07215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FCL46_RS07215	COG2169	Transcriptional regulator
FCL46_RS07245	COG3875	lactate racemase activity
FCL46_RS07260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL46_RS07275	COG0251	oxidation-reduction process
FCL46_RS07305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FCL46_RS07315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FCL46_RS07315	COG3008	intermembrane lipid transfer
FCL46_RS07325	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FCL46_RS07360	COG0577	efflux transmembrane transporter activity
FCL46_RS07360	COG1136	(ABC) transporter
FCL46_RS07365	COG0577	efflux transmembrane transporter activity
FCL46_RS07365	COG1136	(ABC) transporter
FCL46_RS07375	COG1584	GPR1 FUN34 yaaH family protein
FCL46_RS07385	COG2204	response regulator
FCL46_RS07390	COG0840	transmembrane signaling receptor activity
FCL46_RS07400	COG0045	succinate-CoA ligase (ADP-forming) activity
FCL46_RS07405	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FCL46_RS07410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FCL46_RS07425	COG5016	pyruvate
FCL46_RS07425	COG0511	ligase activity, forming carbon-carbon bonds
FCL46_RS07430	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FCL46_RS07440	COG0604	alcohol dehydrogenase
FCL46_RS07450	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FCL46_RS07480	COG2304	oxidoreductase activity
FCL46_RS07505	COG0714	Associated with various cellular activities
FCL46_RS07510	COG3119	arylsulfatase activity
FCL46_RS07515	COG1451	nucleotide metabolic process
FCL46_RS07540	COG2205	protein histidine kinase activity
FCL46_RS07540	COG2198	Histidine kinase
FCL46_RS07540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS07540	COG0784	Response regulator, receiver
FCL46_RS07555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FCL46_RS07565	COG3437	response regulator, receiver
FCL46_RS07570	COG0683	leucine binding
FCL46_RS07580	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FCL46_RS07600	COG4948	Mandelate Racemase Muconate Lactonizing
FCL46_RS07625	COG2204	response regulator
FCL46_RS07640	COG0437	4 iron, 4 sulfur cluster binding
FCL46_RS07640	COG3064	Membrane
FCL46_RS07645	COG5557	Pfam Polysulphide reductase, NrfD
FCL46_RS07660	COG0123	including yeast histone deacetylase and acetoin utilization protein
FCL46_RS07665	COG1289	transmembrane transporter activity
FCL46_RS07670	COG2203	Gaf domain
FCL46_RS07670	COG4251	negative regulation of phosphorylation
FCL46_RS07670	COG3706	GGDEF domain
FCL46_RS07670	COG5001	Diguanylate cyclase
FCL46_RS07685	COG5012	cobalamin binding
FCL46_RS07695	COG4969	Belongs to the N-Me-Phe pilin family
FCL46_RS07735	COG2022	thiamine diphosphate biosynthetic process
FCL46_RS07755	COG1703	isobutyryl-CoA mutase activity
FCL46_RS07760	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL46_RS07760	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL46_RS07765	COG0346	lactoylglutathione lyase activity
FCL46_RS07775	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FCL46_RS07780	COG0511	ligase activity, forming carbon-carbon bonds
FCL46_RS07790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FCL46_RS07815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FCL46_RS07830	COG0145	ligase activity
FCL46_RS07835	COG0123	including yeast histone deacetylase and acetoin utilization protein
FCL46_RS07865	COG2716	regulation of RNA biosynthetic process
FCL46_RS07870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FCL46_RS07895	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FCL46_RS07905	COG0784	Response regulator, receiver
FCL46_RS07905	COG3437	response regulator, receiver
FCL46_RS07915	COG2261	transglycosylase associated protein
FCL46_RS07945	COG0656	L-ascorbic acid biosynthetic process
FCL46_RS07965	COG0656	L-ascorbic acid biosynthetic process
FCL46_RS07970	COG0667	Aldo Keto reductase
FCL46_RS07975	COG2208	phosphoserine phosphatase activity
FCL46_RS07975	COG2770	Histidine kinase
FCL46_RS07980	COG2207	Transcriptional regulator
FCL46_RS07995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS08015	COG0514	ATP-dependent DNA helicase (RecQ)
FCL46_RS08080	COG1522	sequence-specific DNA binding
FCL46_RS08095	COG0330	HflC and HflK could
FCL46_RS08120	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FCL46_RS08140	COG2204	response regulator
FCL46_RS08160	COG0745	RESPONSE REGULATOR receiver
FCL46_RS08170	COG1022	Amp-dependent synthetase and ligase
FCL46_RS08250	COG0517	IMP dehydrogenase activity
FCL46_RS08250	COG0516	GMP reductase activity
FCL46_RS08260	COG2814	Major facilitator Superfamily
FCL46_RS08265	COG0402	S-adenosylhomocysteine deaminase activity
FCL46_RS08270	COG0840	transmembrane signaling receptor activity
FCL46_RS08295	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FCL46_RS08300	COG3842	ATPase activity
FCL46_RS08305	COG1564	THIamine pyrophosphokinase
FCL46_RS08310	COG0318	PFAM AMP-dependent synthetase and ligase
FCL46_RS08325	COG0418	dihydroorotase activity
FCL46_RS08335	COG0427	acetyl-CoA hydrolase
FCL46_RS08340	COG4585	Histidine kinase
FCL46_RS08350	COG0318	PFAM AMP-dependent synthetase and ligase
FCL46_RS08355	COG1024	Enoyl-CoA hydratase
FCL46_RS08360	COG0183	Belongs to the thiolase family
FCL46_RS08365	COG1250	3-hydroxyacyl-CoA dehydrogenase
FCL46_RS08375	COG1960	acyl-CoA dehydrogenase activity
FCL46_RS08380	COG0247	lactate metabolic process
FCL46_RS08380	COG2181	nitrate reductase activity
FCL46_RS08385	COG2086	electron transfer activity
FCL46_RS08390	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FCL46_RS08395	COG0440	acetolactate synthase activity
FCL46_RS08405	COG0730	response to heat
FCL46_RS08430	COG0583	DNA-binding transcription factor activity
FCL46_RS08435	COG5002	protein histidine kinase activity
FCL46_RS08475	COG4191	Histidine kinase
FCL46_RS08505	COG1233	COG1233 Phytoene dehydrogenase and related
FCL46_RS08575	COG0656	L-ascorbic acid biosynthetic process
FCL46_RS08580	COG5002	protein histidine kinase activity
FCL46_RS08585	COG0437	4 iron, 4 sulfur cluster binding
FCL46_RS08620	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FCL46_RS08625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FCL46_RS08630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FCL46_RS08640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FCL46_RS08655	COG0247	lactate metabolic process
FCL46_RS08665	COG4584	PFAM Integrase catalytic
FCL46_RS08670	COG1484	DNA-dependent DNA replication
FCL46_RS08685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FCL46_RS08690	COG2133	pyrroloquinoline quinone binding
FCL46_RS08700	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FCL46_RS08730	COG1454	alcohol dehydrogenase
FCL46_RS08750	COG2198	Histidine kinase
FCL46_RS08750	COG0643	Histidine kinase
FCL46_RS08750	COG0784	Response regulator, receiver
FCL46_RS08760	COG0745	RESPONSE REGULATOR receiver
FCL46_RS08770	COG0840	transmembrane signaling receptor activity
FCL46_RS08800	COG0708	Exodeoxyribonuclease III
FCL46_RS08805	COG3108	Peptidase M15
FCL46_RS08840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL46_RS08845	COG0463	Glycosyl transferase, family 2
FCL46_RS08860	COG2033	superoxide reductase activity
FCL46_RS08885	COG1845	cytochrome c oxidase, subunit III
FCL46_RS08895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FCL46_RS08900	COG0109	protoheme IX farnesyltransferase activity
FCL46_RS08910	COG1528	Iron-storage protein
FCL46_RS08920	COG0450	alkyl hydroperoxide reductase
FCL46_RS08925	COG1773	rubredoxin
FCL46_RS08935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FCL46_RS08940	COG1546	Belongs to the CinA family
FCL46_RS08940	COG1058	Belongs to the CinA family
FCL46_RS08945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL46_RS08950	COG0482	sulfurtransferase activity
FCL46_RS08960	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FCL46_RS08960	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FCL46_RS08980	COG0626	cystathionine gamma-synthase activity
FCL46_RS08995	COG1640	4-alpha-glucanotransferase
FCL46_RS09005	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FCL46_RS09010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FCL46_RS09015	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FCL46_RS09020	COG0163	prenyltransferase activity
FCL46_RS09025	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FCL46_RS09035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FCL46_RS09040	COG1283	sodium-dependent phosphate transmembrane transporter activity
FCL46_RS09045	COG1090	epimerase
FCL46_RS09055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FCL46_RS09085	COG1028	Short-chain dehydrogenase reductase Sdr
FCL46_RS09090	COG2204	response regulator
FCL46_RS09115	COG2855	membrane
FCL46_RS09115	COG2855	membrane
FCL46_RS09120	COG0612	Peptidase, M16
FCL46_RS09160	COG1120	ATPase activity
FCL46_RS09165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FCL46_RS09180	COG0616	signal peptide processing
FCL46_RS09185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FCL46_RS09190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FCL46_RS09195	COG0784	Response regulator, receiver
FCL46_RS09195	COG2205	protein histidine kinase activity
FCL46_RS09215	COG1538	Outer membrane efflux protein
FCL46_RS09230	COG0745	RESPONSE REGULATOR receiver
FCL46_RS09235	COG2205	protein histidine kinase activity
FCL46_RS09240	COG1309	transcriptional regulator
FCL46_RS09250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FCL46_RS09255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL46_RS09270	COG0693	protein deglycase activity
FCL46_RS09295	COG2197	response regulator
FCL46_RS09305	COG2326	polyphosphate kinase activity
FCL46_RS09335	COG1028	Short-chain dehydrogenase reductase Sdr
FCL46_RS09340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FCL46_RS09350	COG0210	DNA helicase
FCL46_RS09405	COG0506	proline dehydrogenase activity
FCL46_RS09410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL46_RS09420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FCL46_RS09445	COG0784	Response regulator, receiver
FCL46_RS09445	COG4191	Histidine kinase
FCL46_RS09450	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FCL46_RS09455	COG1609	Transcriptional regulator
FCL46_RS09470	COG1172	Belongs to the binding-protein-dependent transport system permease family
FCL46_RS09475	COG1879	ABC-type sugar transport system periplasmic component
FCL46_RS09480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FCL46_RS09485	COG0477	Major facilitator Superfamily
FCL46_RS09515	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FCL46_RS09520	COG0778	Nitroreductase
FCL46_RS09530	COG0842	Transport permease protein
FCL46_RS09535	COG1131	(ABC) transporter
FCL46_RS09540	COG0189	ligase activity
FCL46_RS09555	COG4176	ABC-type proline glycine betaine transport system permease component
FCL46_RS09585	COG4977	sequence-specific DNA binding
FCL46_RS09590	COG0243	molybdopterin cofactor binding
FCL46_RS09610	COG2249	NAD(P)H dehydrogenase (quinone) activity
FCL46_RS09625	COG1070	Carbohydrate kinase
FCL46_RS09630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FCL46_RS09635	COG0205	6-phosphofructokinase activity
FCL46_RS09660	COG0613	PHP domain protein
FCL46_RS09665	COG2204	response regulator
FCL46_RS09670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FCL46_RS09675	COG2835	tetraacyldisaccharide 4'-kinase activity
FCL46_RS09680	COG0574	Belongs to the PEP-utilizing enzyme family
FCL46_RS09680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FCL46_RS09685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FCL46_RS09705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FCL46_RS09730	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FCL46_RS09735	COG1678	Uncharacterized ACR, COG1678
FCL46_RS09745	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FCL46_RS09750	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FCL46_RS09755	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FCL46_RS09760	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FCL46_RS09765	COG4191	Histidine kinase
FCL46_RS09765	COG0784	Response regulator, receiver
FCL46_RS09770	COG1643	Atp-dependent helicase
FCL46_RS09775	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FCL46_RS09780	COG3706	GGDEF domain
FCL46_RS09790	COG0281	malic enzyme
FCL46_RS09795	COG1278	Cold shock
FCL46_RS09800	COG0596	Alpha beta hydrolase
FCL46_RS09805	COG0318	PFAM AMP-dependent synthetase and ligase
FCL46_RS09810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FCL46_RS09815	COG4783	chaperone-mediated protein folding
FCL46_RS09820	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FCL46_RS09830	COG0823	Involved in the tonB-independent uptake of proteins
FCL46_RS09850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FCL46_RS09855	COG1028	Short-chain dehydrogenase reductase Sdr
FCL46_RS09870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FCL46_RS09875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FCL46_RS09890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FCL46_RS09905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FCL46_RS09910	COG0521	Mo-molybdopterin cofactor biosynthetic process
FCL46_RS09915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FCL46_RS09930	COG2239	Acts as a magnesium transporter
FCL46_RS09940	COG1253	flavin adenine dinucleotide binding
FCL46_RS09945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FCL46_RS09960	COG0495	leucyl-tRNA aminoacylation
FCL46_RS09965	COG0305	Participates in initiation and elongation during chromosome replication
FCL46_RS09970	COG0359	binds to the 23S rRNA
FCL46_RS09980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FCL46_RS09985	COG0360	Binds together with S18 to 16S ribosomal RNA
FCL46_RS09990	COG3956	TIGRFAM MazG family protein
FCL46_RS10000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FCL46_RS10005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FCL46_RS10010	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FCL46_RS10015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FCL46_RS10020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FCL46_RS10025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FCL46_RS10030	COG2201	protein-glutamate methylesterase activity
FCL46_RS10035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FCL46_RS10040	COG0516	GMP reductase activity
FCL46_RS10040	COG0517	IMP dehydrogenase activity
FCL46_RS10045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FCL46_RS10045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FCL46_RS10060	COG1530	ribonuclease E activity
FCL46_RS10065	COG1216	Glycosyl transferase, family 2
FCL46_RS10065	COG0463	Glycosyl transferase, family 2
FCL46_RS10075	COG0629	single-stranded DNA binding
FCL46_RS10080	COG0484	heat shock protein binding
FCL46_RS10085	COG0066	3-isopropylmalate dehydratase activity
FCL46_RS10090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FCL46_RS10095	COG4166	transmembrane transport
FCL46_RS10100	COG1278	Cold shock
FCL46_RS10105	COG0802	atpase or kinase
FCL46_RS10110	COG1944	ATP diphosphatase activity
FCL46_RS10145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FCL46_RS10150	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FCL46_RS10160	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FCL46_RS10165	COG1797	cobyrinic acid a,c-diamide synthase activity
FCL46_RS10175	COG0105	UTP biosynthetic process
FCL46_RS10190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FCL46_RS10195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FCL46_RS10205	COG0432	Pfam Uncharacterised protein family UPF0047
FCL46_RS10210	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FCL46_RS10215	COG1663	tetraacyldisaccharide 4'-kinase activity
FCL46_RS10235	COG0411	ABC transporter
FCL46_RS10245	COG0673	inositol 2-dehydrogenase activity
FCL46_RS10250	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FCL46_RS10255	COG1193	negative regulation of DNA recombination
FCL46_RS10260	COG0564	pseudouridine synthase activity
FCL46_RS10265	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FCL46_RS10275	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FCL46_RS10280	COG0606	chelatase, subunit chli
FCL46_RS10295	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FCL46_RS10310	COG2204	response regulator
FCL46_RS10335	COG1205	dead DEAH box helicase
FCL46_RS10335	COG1111	helicase
FCL46_RS10345	COG1619	proteins homologs of microcin C7 resistance protein MccF
FCL46_RS10350	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FCL46_RS10385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL46_RS10395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FCL46_RS10400	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FCL46_RS10400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FCL46_RS10405	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FCL46_RS10415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FCL46_RS10420	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FCL46_RS10430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FCL46_RS10435	COG0572	uridine kinase
FCL46_RS10575	COG5002	protein histidine kinase activity
FCL46_RS10655	COG1028	Short-chain dehydrogenase reductase Sdr
FCL46_RS10665	COG0546	phosphoglycolate phosphatase activity
FCL46_RS10665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FCL46_RS10670	COG3437	response regulator, receiver
FCL46_RS10670	COG0784	Response regulator, receiver
FCL46_RS10680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL46_RS10695	COG3852	Histidine kinase
FCL46_RS10705	COG0028	Belongs to the TPP enzyme family
FCL46_RS10710	COG0440	acetolactate synthase activity
FCL46_RS10725	COG5001	Diguanylate cyclase
FCL46_RS10735	COG3300	MHYT domain
FCL46_RS10735	COG5001	Diguanylate cyclase
FCL46_RS10780	COG4172	Belongs to the ABC transporter superfamily
FCL46_RS10790	COG0601	transmembrane transport
FCL46_RS10805	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FCL46_RS10825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL46_RS10830	COG4302	ethanolamine ammonia-lyase activity
FCL46_RS10840	COG1902	pentaerythritol trinitrate reductase activity
FCL46_RS10855	COG2116	formate transmembrane transporter activity
FCL46_RS10870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FCL46_RS10895	COG1484	DNA-dependent DNA replication
FCL46_RS10900	COG4584	PFAM Integrase catalytic
FCL46_RS10920	COG3089	Belongs to the UPF0270 family
FCL46_RS10925	COG0024	Methionine aminopeptidase
FCL46_RS10940	COG1760	l-serine dehydratase
FCL46_RS10965	COG1028	Short-chain dehydrogenase reductase Sdr
FCL46_RS10975	COG0625	glutathione transferase activity
FCL46_RS10980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FCL46_RS11015	COG2384	SAM-dependent methyltransferase
FCL46_RS11025	COG2855	membrane
FCL46_RS11065	COG0589	response to stress
FCL46_RS11075	COG2239	Acts as a magnesium transporter
FCL46_RS11080	COG0589	response to stress
FCL46_RS11110	COG0829	nickel cation binding
FCL46_RS11115	COG0831	urea catabolic process
FCL46_RS11120	COG0832	Belongs to the urease beta subunit family
FCL46_RS11125	COG0804	urea catabolic process
FCL46_RS11130	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FCL46_RS11135	COG0830	nickel cation binding
FCL46_RS11140	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FCL46_RS11170	COG3264	Mechanosensitive ion channel
FCL46_RS11170	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FCL46_RS11175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FCL46_RS11210	COG1484	DNA-dependent DNA replication
FCL46_RS11215	COG4584	PFAM Integrase catalytic
FCL46_RS11225	COG2801	Transposase and inactivated derivatives
FCL46_RS11240	COG0598	Magnesium transport protein CorA
FCL46_RS11245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FCL46_RS11260	COG2239	Acts as a magnesium transporter
FCL46_RS11265	COG3153	acetyltransferase
FCL46_RS11265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FCL46_RS11275	COG0189	ligase activity
FCL46_RS11280	COG0189	ligase activity
FCL46_RS11280	COG4067	protein conserved in archaea
FCL46_RS11305	COG3103	Sh3 type 3 domain protein
FCL46_RS11305	COG1388	LysM domain
FCL46_RS11305	COG0791	NLP P60 protein
FCL46_RS11310	COG1450	Type ii and iii secretion system protein
FCL46_RS11320	COG0730	response to heat
FCL46_RS11345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FCL46_RS11355	COG3119	arylsulfatase activity
FCL46_RS11370	COG2202	Pas domain
FCL46_RS11370	COG1366	Belongs to the anti-sigma-factor antagonist family
FCL46_RS11375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FCL46_RS11485	COG0741	lytic transglycosylase activity
FCL46_RS11485	COG1196	nuclear chromosome segregation
FCL46_RS11485	COG0739	heme binding
FCL46_RS11540	COG4974	Belongs to the 'phage' integrase family
FCL46_RS11590	COG0471	metal ion transport
FCL46_RS11590	COG3273	potassium ion transport
FCL46_RS11600	COG0564	pseudouridine synthase activity
FCL46_RS11610	COG4399	Belongs to the UPF0754 family
FCL46_RS11615	COG0546	phosphoglycolate phosphatase activity
FCL46_RS11625	COG1053	succinate dehydrogenase
FCL46_RS11650	COG0308	aminopeptidase N
FCL46_RS11655	COG0436	Aminotransferase
FCL46_RS11660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FCL46_RS11670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FCL46_RS11675	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FCL46_RS11680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL46_RS11700	COG0107	imidazoleglycerol-phosphate synthase activity
FCL46_RS11725	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FCL46_RS11735	COG1606	tRNA processing
FCL46_RS11745	COG1605	Chorismate mutase
FCL46_RS11745	COG0077	Prephenate dehydratase
FCL46_RS11750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FCL46_RS11760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FCL46_RS11765	COG1979	alcohol dehydrogenase
FCL46_RS11795	COG1227	inorganic diphosphatase activity
FCL46_RS11835	COG0243	molybdopterin cofactor binding
FCL46_RS11845	COG0488	(ABC) transporter
FCL46_RS11855	COG0009	L-threonylcarbamoyladenylate synthase
FCL46_RS11860	COG0151	Belongs to the GarS family
FCL46_RS11865	COG1309	transcriptional regulator
FCL46_RS11870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FCL46_RS11885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FCL46_RS11890	COG0481	GTPase activity
FCL46_RS11925	COG1012	belongs to the aldehyde dehydrogenase family
FCL46_RS11930	COG0506	proline dehydrogenase activity
FCL46_RS11940	COG2205	protein histidine kinase activity
FCL46_RS11950	COG2204	response regulator
FCL46_RS11965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FCL46_RS11980	COG0156	8-amino-7-oxononanoate synthase activity
FCL46_RS11990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FCL46_RS11995	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FCL46_RS12000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FCL46_RS12005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FCL46_RS12010	COG2884	Cell division ATP-binding protein ftsE
FCL46_RS12015	COG2177	Part of the ABC transporter FtsEX involved in
FCL46_RS12025	COG0793	Belongs to the peptidase S41A family
FCL46_RS12040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FCL46_RS12045	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FCL46_RS12065	COG1279	arginine transmembrane transporter activity
FCL46_RS12080	COG1683	Conserved Protein
FCL46_RS12100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FCL46_RS12105	COG1333	cytochrome c biogenesis protein
FCL46_RS12120	COG0751	glycine-tRNA ligase activity
FCL46_RS12125	COG1469	GTP cyclohydrolase I activity
FCL46_RS12140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FCL46_RS12145	COG0315	cyclic pyranopterin monophosphate synthase activity
FCL46_RS12150	COG0484	heat shock protein binding
FCL46_RS12155	COG1758	RNA polymerase activity
FCL46_RS12160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FCL46_RS12165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FCL46_RS12170	COG0805	protein transport
FCL46_RS12180	COG0590	tRNA wobble adenosine to inosine editing
FCL46_RS12180	COG0037	tRNA processing
FCL46_RS12205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FCL46_RS12210	COG2046	Belongs to the sulfate adenylyltransferase family
FCL46_RS12215	COG2217	Heavy metal translocating P-type atpase
FCL46_RS12250	COG2204	response regulator
FCL46_RS12255	COG3852	Histidine kinase
FCL46_RS12320	COG4969	Belongs to the N-Me-Phe pilin family
FCL46_RS12335	COG4968	Prepilin-type N-terminal cleavage methylation domain
FCL46_RS12370	COG1131	(ABC) transporter
FCL46_RS12390	COG1216	Glycosyl transferase, family 2
FCL46_RS12395	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS12400	COG1216	Glycosyl transferase, family 2
FCL46_RS12435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FCL46_RS12445	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FCL46_RS12475	COG2204	response regulator
FCL46_RS12480	COG2807	transmembrane transport
FCL46_RS12485	COG0215	cysteine-tRNA ligase activity
FCL46_RS12490	COG1355	regulation of microtubule-based process
FCL46_RS12505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FCL46_RS12520	COG0037	tRNA processing
FCL46_RS12530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL46_RS12535	COG0489	protein tyrosine kinase activity
FCL46_RS12540	COG0552	protein localization to endoplasmic reticulum
FCL46_RS12545	COG0484	heat shock protein binding
FCL46_RS12550	COG0436	Aminotransferase
FCL46_RS12565	COG1213	nucleotidyl transferase
FCL46_RS12575	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FCL46_RS12580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FCL46_RS12585	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FCL46_RS12590	COG3876	Protein conserved in bacteria
FCL46_RS12595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FCL46_RS12600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FCL46_RS12620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FCL46_RS12620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FCL46_RS12625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FCL46_RS12630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FCL46_RS12635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FCL46_RS12640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FCL46_RS12655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FCL46_RS12660	COG0045	succinate-CoA ligase (ADP-forming) activity
FCL46_RS12670	COG1013	pyruvate-flavodoxin oxidoreductase activity
FCL46_RS12675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FCL46_RS12675	COG0674	pyruvate-flavodoxin oxidoreductase activity
FCL46_RS12685	COG1802	Transcriptional regulator
FCL46_RS12690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FCL46_RS12695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FCL46_RS12710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FCL46_RS12715	COG3012	SEC-C Motif Domain Protein
FCL46_RS12720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FCL46_RS12745	COG0463	Glycosyl transferase, family 2
FCL46_RS12765	COG1215	transferase activity, transferring glycosyl groups
FCL46_RS12770	COG1404	Belongs to the peptidase S8 family
FCL46_RS12775	COG1216	Glycosyl transferase, family 2
FCL46_RS12800	COG0463	Glycosyl transferase, family 2
FCL46_RS12815	COG0463	Glycosyl transferase, family 2
FCL46_RS12830	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS12855	COG2089	acid synthase
FCL46_RS12860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FCL46_RS12865	COG1083	cytidylyl-transferase
FCL46_RS12870	COG1012	belongs to the aldehyde dehydrogenase family
FCL46_RS12875	COG1028	Short-chain dehydrogenase reductase Sdr
FCL46_RS12880	COG1216	Glycosyl transferase, family 2
FCL46_RS12905	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS12955	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS12960	COG1215	transferase activity, transferring glycosyl groups
FCL46_RS12985	COG1682	transport, permease protein
FCL46_RS12995	COG1132	(ABC) transporter
FCL46_RS13000	COG3307	-O-antigen
FCL46_RS13005	COG4191	Histidine kinase
FCL46_RS13015	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FCL46_RS13020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FCL46_RS13025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FCL46_RS13030	COG1047	Peptidyl-prolyl cis-trans
FCL46_RS13035	COG0643	Histidine kinase
FCL46_RS13035	COG2198	Histidine kinase
FCL46_RS13035	COG0784	Response regulator, receiver
FCL46_RS13040	COG0835	chemotaxis
FCL46_RS13045	COG2201	protein-glutamate methylesterase activity
FCL46_RS13050	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FCL46_RS13055	COG2204	response regulator
FCL46_RS13070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FCL46_RS13075	COG2204	response regulator
FCL46_RS13090	COG3335	DDE superfamily endonuclease
FCL46_RS13100	COG0745	RESPONSE REGULATOR receiver
FCL46_RS13115	COG1558	bacterial-type flagellum-dependent cell motility
FCL46_RS13120	COG1677	Flagellar hook-basal body complex protein FliE
FCL46_RS13130	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FCL46_RS13140	COG1157	protein secretion by the type III secretion system
FCL46_RS13160	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FCL46_RS13170	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FCL46_RS13175	COG1360	Flagellar Motor Protein
FCL46_RS13180	COG1580	Controls the rotational direction of flagella during chemotaxis
FCL46_RS13200	COG1338	Plays a role in the flagellum-specific transport system
FCL46_RS13205	COG1987	bacterial-type flagellum assembly
FCL46_RS13210	COG1684	flagellar biosynthetic protein fliR
FCL46_RS13215	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FCL46_RS13220	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FCL46_RS13235	COG1191	sigma factor activity
FCL46_RS13245	COG4786	Flagellar basal body rod
FCL46_RS13250	COG4786	Flagellar basal body rod
FCL46_RS13260	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FCL46_RS13265	COG1706	bacterial-type flagellum-dependent cell motility
FCL46_RS13275	COG4191	Histidine kinase
FCL46_RS13275	COG0784	Response regulator, receiver
FCL46_RS13290	COG2747	anti-sigma28 factor FlgM
FCL46_RS13300	COG4786	Flagellar basal body rod
FCL46_RS13310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FCL46_RS13315	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
FCL46_RS13350	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FCL46_RS13355	COG1516	flagellar protein fliS
FCL46_RS13385	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FCL46_RS13405	COG0543	2 iron, 2 sulfur cluster binding
FCL46_RS13430	COG0646	methionine synthase
FCL46_RS13430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FCL46_RS13445	COG1233	COG1233 Phytoene dehydrogenase and related
FCL46_RS13465	COG0745	RESPONSE REGULATOR receiver
FCL46_RS13480	COG3852	Histidine kinase
FCL46_RS13485	COG0247	lactate metabolic process
FCL46_RS13485	COG2181	nitrate reductase activity
FCL46_RS13510	COG0840	transmembrane signaling receptor activity
FCL46_RS13530	COG1151	hydroxylamine reductase activity
FCL46_RS13560	COG1151	hydroxylamine reductase activity
FCL46_RS13580	COG1592	Rubrerythrin
FCL46_RS13605	COG0840	transmembrane signaling receptor activity
FCL46_RS13610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FCL46_RS13610	COG2199	diguanylate cyclase activity
FCL46_RS13615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FCL46_RS13620	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FCL46_RS13640	COG0427	acetyl-CoA hydrolase
FCL46_RS13655	COG1376	ErfK ybiS ycfS ynhG family protein
FCL46_RS13655	COG1388	LysM domain
FCL46_RS13660	COG1960	acyl-CoA dehydrogenase activity
FCL46_RS13665	COG1024	Enoyl-CoA hydratase
FCL46_RS13680	COG1250	3-hydroxyacyl-CoA dehydrogenase
FCL46_RS13685	COG0183	Belongs to the thiolase family
FCL46_RS13690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FCL46_RS13695	COG1960	acyl-CoA dehydrogenase activity
FCL46_RS13700	COG2086	electron transfer activity
FCL46_RS13705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FCL46_RS13710	COG1309	transcriptional regulator
FCL46_RS13715	COG1703	isobutyryl-CoA mutase activity
FCL46_RS13715	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL46_RS13715	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL46_RS13725	COG0723	plastoquinol--plastocyanin reductase activity
FCL46_RS13730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FCL46_RS13735	COG3119	arylsulfatase activity
FCL46_RS13750	COG3594	Acyltransferase
FCL46_RS13755	COG3842	ATPase activity
FCL46_RS13760	COG0436	Aminotransferase
FCL46_RS13765	COG1760	l-serine dehydratase
FCL46_RS13770	COG2985	domain, Protein
FCL46_RS13770	COG0569	domain protein
FCL46_RS13775	COG1187	pseudouridine synthase activity
FCL46_RS13790	COG0437	4 iron, 4 sulfur cluster binding
FCL46_RS13830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FCL46_RS13835	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FCL46_RS13840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL46_RS13850	COG1418	mRNA catabolic process
FCL46_RS13855	COG2204	response regulator
FCL46_RS13865	COG1067	ATP-dependent peptidase activity
FCL46_RS13885	COG1028	Short-chain dehydrogenase reductase Sdr
FCL46_RS13890	COG1611	Belongs to the LOG family
FCL46_RS13895	COG0133	tryptophan synthase activity
FCL46_RS13910	COG1307	EDD domain protein, DegV family
FCL46_RS13915	COG1126	abc transporter atp-binding protein
FCL46_RS13920	COG0765	amino acid transport
FCL46_RS13925	COG4597	amino acid ABC transporter
FCL46_RS13930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS13935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS13950	COG1126	abc transporter atp-binding protein
FCL46_RS13960	COG3257	ureidoglycine aminohydrolase activity
FCL46_RS13990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FCL46_RS14010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FCL46_RS14015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FCL46_RS14020	COG0778	Nitroreductase
FCL46_RS14025	COG1741	Belongs to the pirin family
FCL46_RS14040	COG3852	Histidine kinase
FCL46_RS14045	COG0745	RESPONSE REGULATOR receiver
FCL46_RS14050	COG0243	molybdopterin cofactor binding
FCL46_RS14060	COG5001	Diguanylate cyclase
FCL46_RS14060	COG4251	negative regulation of phosphorylation
FCL46_RS14060	COG3706	GGDEF domain
FCL46_RS14060	COG2203	Gaf domain
FCL46_RS14085	COG2204	response regulator
FCL46_RS14100	COG1228	amidohydrolase
FCL46_RS14105	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FCL46_RS14110	COG2986	histidine ammonia-lyase
FCL46_RS14120	COG3530	Putative quorum-sensing-regulated virulence factor
FCL46_RS14175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FCL46_RS14180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FCL46_RS14185	COG0740	serine-type endopeptidase activity
FCL46_RS14190	COG0544	peptidyl-prolyl cis-trans isomerase activity
FCL46_RS14205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FCL46_RS14205	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FCL46_RS14210	COG1702	phosphate starvation-inducible protein PhoH
FCL46_RS14215	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FCL46_RS14285	COG3597	protein domain associated with
FCL46_RS14310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS14325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FCL46_RS14330	COG0135	phosphoribosylanthranilate isomerase activity
FCL46_RS14335	COG0134	indole-3-glycerol-phosphate synthase activity
FCL46_RS14340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FCL46_RS14345	COG0512	Glutamine amidotransferase of anthranilate synthase
FCL46_RS14350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FCL46_RS14355	COG0268	Binds directly to 16S ribosomal RNA
FCL46_RS14370	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FCL46_RS14375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FCL46_RS14380	COG0138	bifunctional purine biosynthesis protein purh
FCL46_RS14385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FCL46_RS14390	COG1469	GTP cyclohydrolase I activity
FCL46_RS14405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FCL46_RS14410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FCL46_RS14425	COG0776	regulation of translation
FCL46_RS14445	COG0668	transmembrane transport
FCL46_RS14455	COG1032	radical SAM domain protein
FCL46_RS14465	COG1794	racemase activity, acting on amino acids and derivatives
FCL46_RS14520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FCL46_RS14530	COG0791	NLP P60 protein
FCL46_RS14535	COG3028	Belongs to the UPF0307 family
FCL46_RS14550	COG0303	'Molybdopterin
FCL46_RS14555	COG0303	'Molybdopterin
FCL46_RS14575	COG1254	Belongs to the acylphosphatase family
FCL46_RS14580	COG4172	Belongs to the ABC transporter superfamily
FCL46_RS14585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FCL46_RS14590	COG0322	excinuclease ABC activity
FCL46_RS14600	COG1216	Glycosyl transferase, family 2
FCL46_RS14600	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS14610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FCL46_RS14620	COG0658	competence protein
FCL46_RS14620	COG2333	competence protein COMEC
FCL46_RS14640	COG1921	L-seryl-tRNASec selenium transferase activity
FCL46_RS14685	COG2204	response regulator
FCL46_RS14705	COG0745	RESPONSE REGULATOR receiver
FCL46_RS14720	COG2204	response regulator
FCL46_RS14735	COG0745	RESPONSE REGULATOR receiver
FCL46_RS14750	COG0205	6-phosphofructokinase activity
FCL46_RS14760	COG0640	Transcriptional regulator
FCL46_RS14765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FCL46_RS14775	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
FCL46_RS14780	COG0133	tryptophan synthase activity
FCL46_RS14785	COG0159	tryptophan synthase activity
FCL46_RS14790	COG1164	Oligoendopeptidase f
FCL46_RS14795	COG2204	response regulator
FCL46_RS14815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FCL46_RS14820	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FCL46_RS14825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FCL46_RS14835	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FCL46_RS14840	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FCL46_RS14845	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FCL46_RS14850	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FCL46_RS14855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FCL46_RS14860	COG0072	phenylalanine-tRNA ligase activity
FCL46_RS14860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FCL46_RS14880	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FCL46_RS14910	COG3591	Belongs to the peptidase S1B family
FCL46_RS15000	COG2205	protein histidine kinase activity
FCL46_RS15000	COG0784	Response regulator, receiver
FCL46_RS15010	COG0745	RESPONSE REGULATOR receiver
FCL46_RS15015	COG1366	Belongs to the anti-sigma-factor antagonist family
FCL46_RS15025	COG0058	SHG alpha-glucan phosphorylase activity
FCL46_RS15035	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FCL46_RS15040	COG1494	fructose-1,6-bisphosphatase
FCL46_RS15065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FCL46_RS15075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FCL46_RS15105	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FCL46_RS15115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL46_RS15140	COG0191	fructose-bisphosphate aldolase activity
FCL46_RS15145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FCL46_RS15160	COG0484	heat shock protein binding
FCL46_RS15165	COG0501	Belongs to the peptidase M48B family
FCL46_RS15200	COG3119	arylsulfatase activity
FCL46_RS15275	COG3976	FMN-binding domain protein
FCL46_RS15275	COG1053	succinate dehydrogenase
FCL46_RS15290	COG4134	Bacterial extracellular solute-binding protein
FCL46_RS15300	COG2264	protein methyltransferase activity
FCL46_RS15310	COG0583	DNA-binding transcription factor activity
FCL46_RS15335	COG0492	ferredoxin-NADP+ reductase activity
FCL46_RS15340	COG3118	belongs to the thioredoxin family
FCL46_RS15365	COG2909	trisaccharide binding
FCL46_RS15370	COG0668	transmembrane transport
FCL46_RS15385	COG4659	FMN binding
FCL46_RS15435	COG0281	malic enzyme
FCL46_RS15440	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FCL46_RS15450	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FCL46_RS15465	COG0517	IMP dehydrogenase activity
FCL46_RS15470	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FCL46_RS15470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FCL46_RS15490	COG1136	(ABC) transporter
FCL46_RS15510	COG0488	(ABC) transporter
FCL46_RS15520	COG0571	ribonuclease III activity
FCL46_RS15530	COG0058	SHG alpha-glucan phosphorylase activity
FCL46_RS15545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FCL46_RS15550	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FCL46_RS15555	COG1045	serine acetyltransferase
FCL46_RS15560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FCL46_RS15570	COG0583	DNA-binding transcription factor activity
FCL46_RS15575	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS15585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FCL46_RS15645	COG1459	type II secretion system
FCL46_RS15650	COG3267	Type II secretory pathway component ExeA
FCL46_RS15650	COG3409	Peptidoglycan-binding domain 1 protein
FCL46_RS15665	COG2205	protein histidine kinase activity
FCL46_RS15665	COG0784	Response regulator, receiver
FCL46_RS15675	COG1744	ABC transporter substrate-binding protein PnrA-like
FCL46_RS15700	COG4303	Ethanolamine ammonia lyase large subunit
FCL46_RS15705	COG4302	ethanolamine ammonia-lyase activity
FCL46_RS15725	COG2414	aldehyde ferredoxin oxidoreductase
FCL46_RS15730	COG3254	rhamnose metabolic process
FCL46_RS15735	COG1172	Belongs to the binding-protein-dependent transport system permease family
FCL46_RS15740	COG1172	Belongs to the binding-protein-dependent transport system permease family
FCL46_RS15745	COG1129	ABC transporter
FCL46_RS15750	COG1879	ABC-type sugar transport system periplasmic component
FCL46_RS15755	COG0235	Class ii aldolase
FCL46_RS15760	COG4806	L-rhamnose isomerase
FCL46_RS15765	COG1070	Carbohydrate kinase
FCL46_RS15775	COG1053	succinate dehydrogenase
FCL46_RS15775	COG3976	FMN-binding domain protein
FCL46_RS15780	COG1053	succinate dehydrogenase
FCL46_RS15795	COG0427	acetyl-CoA hydrolase
FCL46_RS15830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FCL46_RS15845	COG4221	oxidoreductase activity
FCL46_RS15880	COG1530	ribonuclease E activity
FCL46_RS15885	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FCL46_RS15895	COG2951	lytic endotransglycosylase activity
FCL46_RS15910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FCL46_RS15915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FCL46_RS15925	COG0543	2 iron, 2 sulfur cluster binding
FCL46_RS15945	COG0437	4 iron, 4 sulfur cluster binding
FCL46_RS15985	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FCL46_RS15990	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FCL46_RS15995	COG1648	precorrin-2 dehydrogenase activity
FCL46_RS15995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FCL46_RS16005	COG1968	undecaprenyl-diphosphatase activity
FCL46_RS16015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FCL46_RS16020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FCL46_RS16030	COG1381	Involved in DNA repair and RecF pathway recombination
FCL46_RS16060	COG2226	methyltransferase
FCL46_RS16065	COG0500	methyltransferase
FCL46_RS16075	COG1028	Short-chain dehydrogenase reductase Sdr
FCL46_RS16080	COG0505	Belongs to the CarA family
FCL46_RS16085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FCL46_RS16090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FCL46_RS16095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FCL46_RS16105	COG2183	response to ionizing radiation
FCL46_RS16115	COG0395	ABC-type sugar transport system, permease component
FCL46_RS16130	COG3842	ATPase activity
FCL46_RS16135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FCL46_RS16155	COG5002	protein histidine kinase activity
FCL46_RS16170	COG1309	transcriptional regulator
FCL46_RS16175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL46_RS16195	COG2205	protein histidine kinase activity
FCL46_RS16195	COG5002	protein histidine kinase activity
FCL46_RS16195	COG0784	Response regulator, receiver
FCL46_RS16210	COG3437	response regulator, receiver
FCL46_RS16210	COG0784	Response regulator, receiver
FCL46_RS16225	COG2801	Transposase and inactivated derivatives
FCL46_RS16235	COG1960	acyl-CoA dehydrogenase activity
FCL46_RS16240	COG2223	nitrite transmembrane transporter activity
FCL46_RS16260	COG0318	PFAM AMP-dependent synthetase and ligase
FCL46_RS16265	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FCL46_RS16275	COG0247	lactate metabolic process
FCL46_RS16275	COG2181	nitrate reductase activity
FCL46_RS16355	COG0386	Belongs to the glutathione peroxidase family
FCL46_RS16385	COG0702	epimerase
FCL46_RS16395	COG1309	transcriptional regulator
FCL46_RS16405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FCL46_RS16410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FCL46_RS16415	COG1116	anion transmembrane transporter activity
FCL46_RS16420	COG0352	thiamine-phosphate diphosphorylase activity
FCL46_RS16425	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FCL46_RS16430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FCL46_RS16450	COG0022	dehydrogenase e1 component
FCL46_RS16460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FCL46_RS16465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FCL46_RS16475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL46_RS16475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL46_RS16475	COG1703	isobutyryl-CoA mutase activity
FCL46_RS16500	COG0488	(ABC) transporter
FCL46_RS16505	COG0488	(ABC) transporter
FCL46_RS16510	COG0725	ABC transporter, periplasmic molybdate-binding protein
FCL46_RS16515	COG4149	molybdate abc transporter
FCL46_RS16520	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FCL46_RS16525	COG2195	Cleaves the N-terminal amino acid of tripeptides
FCL46_RS16535	COG0693	protein deglycase activity
FCL46_RS16555	COG0513	Belongs to the DEAD box helicase family
FCL46_RS16615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FCL46_RS16620	COG2204	response regulator
FCL46_RS16640	COG0437	4 iron, 4 sulfur cluster binding
FCL46_RS16655	COG3775	system Galactitol-specific IIC component
FCL46_RS16670	COG0598	Magnesium transport protein CorA
FCL46_RS16675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FCL46_RS16675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL46_RS16695	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FCL46_RS16735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL46_RS16765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL46_RS16790	COG2358	TRAP transporter, solute receptor (TAXI family
FCL46_RS16800	COG0277	FAD linked oxidase domain protein
FCL46_RS16810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FCL46_RS16815	COG0583	DNA-binding transcription factor activity
FCL46_RS16820	COG1027	Aspartate ammonia-lyase
FCL46_RS16830	COG0667	Aldo Keto reductase
FCL46_RS16835	COG2414	aldehyde ferredoxin oxidoreductase
FCL46_RS16840	COG1012	belongs to the aldehyde dehydrogenase family
FCL46_RS16845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FCL46_RS16855	COG1882	Formate acetyltransferase
FCL46_RS16865	COG2204	response regulator
FCL46_RS16875	COG2814	Major facilitator Superfamily
FCL46_RS16890	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL46_RS16900	COG1140	nitrate reductase beta subunit
FCL46_RS16905	COG0243	molybdopterin cofactor binding
FCL46_RS16920	COG3123	guanosine phosphorylase activity
FCL46_RS16925	COG2130	NADP-dependent
FCL46_RS16940	COG3789	protein conserved in bacteria
FCL46_RS16945	COG1842	Phage shock protein A
FCL46_RS16960	COG5463	Belongs to the UPF0441 family
FCL46_RS16965	COG0754	glutathionylspermidine amidase activity
FCL46_RS16985	COG0569	domain protein
FCL46_RS16990	COG3260	NADH ubiquinone oxidoreductase 20
FCL46_RS16995	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL46_RS16995	COG0649	NAD binding
FCL46_RS16995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL46_RS17000	COG0651	ATP synthesis coupled electron transport
FCL46_RS17015	COG0651	ATP synthesis coupled electron transport
FCL46_RS17115	COG4191	Histidine kinase
FCL46_RS17120	COG0303	'Molybdopterin
FCL46_RS17125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FCL46_RS17130	COG2084	Dehydrogenase
FCL46_RS17135	COG0784	Response regulator, receiver
FCL46_RS17135	COG5002	protein histidine kinase activity
FCL46_RS17135	COG2205	protein histidine kinase activity
FCL46_RS17155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FCL46_RS17170	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FCL46_RS17175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FCL46_RS17180	COG1960	acyl-CoA dehydrogenase activity
FCL46_RS17195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL46_RS17205	COG0446	pyridine nucleotide-disulphide oxidoreductase
FCL46_RS17210	COG1090	epimerase
FCL46_RS17230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FCL46_RS17275	COG0149	triose-phosphate isomerase activity
FCL46_RS17290	COG3842	ATPase activity
FCL46_RS17295	COG3842	ATPase activity
FCL46_RS17305	COG0395	ABC-type sugar transport system, permease component
FCL46_RS17320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FCL46_RS17340	COG0471	metal ion transport
FCL46_RS17360	COG1854	S-ribosylhomocysteine lyase activity
FCL46_RS17365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FCL46_RS17370	COG0583	DNA-binding transcription factor activity
FCL46_RS17390	COG3384	dioxygenase
FCL46_RS17400	COG0745	RESPONSE REGULATOR receiver
FCL46_RS17425	COG0583	DNA-binding transcription factor activity
FCL46_RS17440	COG3437	response regulator, receiver
FCL46_RS17440	COG2770	Histidine kinase
FCL46_RS17460	COG2319	Wd-40 repeat
FCL46_RS17460	COG4249	Peptidase C14 caspase catalytic subunit p20
FCL46_RS17490	COG0604	alcohol dehydrogenase
FCL46_RS17495	COG2208	phosphoserine phosphatase activity
FCL46_RS17530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FCL46_RS17535	COG2267	carboxylic ester hydrolase activity
FCL46_RS17545	COG3706	GGDEF domain
FCL46_RS17600	COG1802	Transcriptional regulator
FCL46_RS17640	COG0564	pseudouridine synthase activity
FCL46_RS17645	COG0513	Belongs to the DEAD box helicase family
FCL46_RS17660	COG2197	response regulator
FCL46_RS17665	COG4585	Histidine kinase
FCL46_RS17670	COG4214	carbohydrate transport
FCL46_RS17680	COG4213	ABC transporter substrate-binding protein
FCL46_RS17685	COG1940	carbohydrate kinase activity
FCL46_RS17695	COG1070	Carbohydrate kinase
FCL46_RS17720	COG0659	secondary active sulfate transmembrane transporter activity
FCL46_RS17725	COG4807	Protein conserved in bacteria
FCL46_RS17735	COG4120	Belongs to the binding-protein-dependent transport system permease family
FCL46_RS17745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL46_RS17765	COG1660	Displays ATPase and GTPase activities
FCL46_RS17775	COG0534	Mate efflux family protein
FCL46_RS17780	COG2201	protein-glutamate methylesterase activity
FCL46_RS17785	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FCL46_RS17795	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FCL46_RS17805	COG0564	pseudouridine synthase activity
FCL46_RS17815	COG1160	GTP binding
FCL46_RS17825	COG1690	Belongs to the RtcB family
FCL46_RS17830	COG0259	pyridoxamine-phosphate oxidase activity
FCL46_RS17845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL46_RS17850	COG1047	Peptidyl-prolyl cis-trans
FCL46_RS17870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FCL46_RS17880	COG1104	cysteine desulfurase activity
FCL46_RS17915	COG1819	glycosyl
FCL46_RS17925	COG0346	lactoylglutathione lyase activity
FCL46_RS17940	COG1234	tRNA 3'-trailer cleavage
FCL46_RS17950	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FCL46_RS17960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FCL46_RS17965	COG0745	RESPONSE REGULATOR receiver
FCL46_RS17975	COG5002	protein histidine kinase activity
FCL46_RS18055	COG1528	Iron-storage protein
FCL46_RS18065	COG1271	oxidase subunit
FCL46_RS18070	COG1294	oxidase, subunit
FCL46_RS18080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FCL46_RS18085	COG1121	(ABC) transporter
FCL46_RS18105	COG0765	amino acid transport
FCL46_RS18110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS18120	COG0156	8-amino-7-oxononanoate synthase activity
FCL46_RS18125	COG1063	alcohol dehydrogenase
FCL46_RS18140	COG0531	amino acid
FCL46_RS18155	COG1121	(ABC) transporter
FCL46_RS18190	COG2304	oxidoreductase activity
FCL46_RS18195	COG0745	RESPONSE REGULATOR receiver
FCL46_RS18200	COG5002	protein histidine kinase activity
FCL46_RS18210	COG0347	Belongs to the P(II) protein family
FCL46_RS18225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FCL46_RS18230	COG3273	potassium ion transport
FCL46_RS18230	COG0471	metal ion transport
FCL46_RS18245	COG0725	ABC transporter, periplasmic molybdate-binding protein
FCL46_RS18255	COG0560	Phosphoserine phosphatase
FCL46_RS18255	COG3830	Belongs to the UPF0237 family
FCL46_RS18260	COG0179	Fumarylacetoacetate (FAA) hydrolase
FCL46_RS18265	COG1902	pentaerythritol trinitrate reductase activity
FCL46_RS18265	COG0446	pyridine nucleotide-disulphide oxidoreductase
FCL46_RS18275	COG2067	long-chain fatty acid transport protein
FCL46_RS18280	COG0824	Thioesterase
FCL46_RS18290	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FCL46_RS18295	COG2086	electron transfer activity
FCL46_RS18300	COG2181	nitrate reductase activity
FCL46_RS18300	COG0247	lactate metabolic process
FCL46_RS18305	COG1960	acyl-CoA dehydrogenase activity
FCL46_RS18325	COG0511	ligase activity, forming carbon-carbon bonds
FCL46_RS18325	COG5016	pyruvate
FCL46_RS18330	COG0439	Biotin carboxylase
FCL46_RS18385	COG0243	molybdopterin cofactor binding
FCL46_RS18400	COG0437	4 iron, 4 sulfur cluster binding
FCL46_RS18425	COG1902	pentaerythritol trinitrate reductase activity
FCL46_RS18425	COG0446	pyridine nucleotide-disulphide oxidoreductase
FCL46_RS18435	COG1960	acyl-CoA dehydrogenase activity
FCL46_RS18440	COG0183	Belongs to the thiolase family
FCL46_RS18445	COG1024	Enoyl-CoA hydratase
FCL46_RS18445	COG1250	3-hydroxyacyl-CoA dehydrogenase
FCL46_RS18455	COG0183	Belongs to the thiolase family
FCL46_RS18460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FCL46_RS18465	COG5002	protein histidine kinase activity
FCL46_RS18465	COG2205	protein histidine kinase activity
FCL46_RS18465	COG0784	Response regulator, receiver
FCL46_RS18470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FCL46_RS18475	COG1811	Na channel or pump
FCL46_RS18500	COG0589	response to stress
FCL46_RS18520	COG2197	response regulator
FCL46_RS18535	COG1335	isochorismatase
FCL46_RS18540	COG0513	Belongs to the DEAD box helicase family
FCL46_RS18545	COG2204	response regulator
FCL46_RS18560	COG2204	response regulator
FCL46_RS18570	COG2204	response regulator
FCL46_RS18575	COG0745	RESPONSE REGULATOR receiver
FCL46_RS18590	COG2204	response regulator
FCL46_RS18605	COG1024	Enoyl-CoA hydratase
FCL46_RS18630	COG3118	belongs to the thioredoxin family
FCL46_RS18660	COG4584	PFAM Integrase catalytic
FCL46_RS18665	COG1484	DNA-dependent DNA replication
FCL46_RS18680	COG0789	Transcriptional regulator
FCL46_RS18680	COG4978	Transcriptional regulator
FCL46_RS18700	COG1012	belongs to the aldehyde dehydrogenase family
FCL46_RS18700	COG1454	alcohol dehydrogenase
FCL46_RS18705	COG1882	Formate acetyltransferase
FCL46_RS18710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FCL46_RS18720	COG1012	belongs to the aldehyde dehydrogenase family
FCL46_RS18720	COG1454	alcohol dehydrogenase
FCL46_RS18730	COG4869	propanediol catabolic process
FCL46_RS18770	COG4656	Part of a membrane complex involved in electron transport
FCL46_RS18810	COG3706	GGDEF domain
FCL46_RS18845	COG1012	belongs to the aldehyde dehydrogenase family
FCL46_RS18850	COG0673	inositol 2-dehydrogenase activity
FCL46_RS18875	COG1012	belongs to the aldehyde dehydrogenase family
FCL46_RS18880	COG1953	Uracil, thiamine, allantoin
FCL46_RS18895	COG0589	response to stress
FCL46_RS18950	COG0525	valine-tRNA ligase activity
FCL46_RS18955	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FCL46_RS18980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FCL46_RS19005	COG0674	pyruvate-flavodoxin oxidoreductase activity
FCL46_RS19005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FCL46_RS19030	COG4964	Belongs to the GSP D family
FCL46_RS19085	COG0702	epimerase
FCL46_RS19090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FCL46_RS19105	COG1309	transcriptional regulator
FCL46_RS19110	COG0500	methyltransferase
FCL46_RS19120	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FCL46_RS19200	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FCL46_RS19205	COG2814	Major facilitator Superfamily
FCL46_RS19215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FCL46_RS19220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL46_RS19245	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FCL46_RS19250	COG1805	sodium ion transport
FCL46_RS19260	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FCL46_RS19265	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FCL46_RS19270	COG2871	sodium ion transport
FCL46_RS19285	COG0686	Belongs to the AlaDH PNT family
FCL46_RS19320	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FCL46_RS19325	COG4535	Mg2 and Co2 transporter CorC
FCL46_RS19330	COG0439	Biotin carboxylase
FCL46_RS19335	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FCL46_RS19345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FCL46_RS19385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FCL46_RS19390	COG0038	chloride channel
FCL46_RS19395	COG0493	'glutamate synthase
FCL46_RS19400	COG0069	glutamate synthase activity
FCL46_RS19400	COG0067	glutamate synthase
FCL46_RS19400	COG0070	glutamate synthase
FCL46_RS19410	COG1744	ABC transporter substrate-binding protein PnrA-like
FCL46_RS19475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FCL46_RS19530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FCL46_RS19545	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FCL46_RS19550	COG2815	serine threonine protein kinase
FCL46_RS19550	COG0515	serine threonine protein kinase
FCL46_RS19560	COG0488	(ABC) transporter
FCL46_RS19565	COG0739	heme binding
FCL46_RS19585	COG2920	part of a sulfur-relay system
FCL46_RS19590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FCL46_RS19595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FCL46_RS19610	COG0563	adenylate kinase activity
FCL46_RS19620	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
FCL46_RS19625	COG0824	Thioesterase
FCL46_RS19645	COG0826	peptidase U32
FCL46_RS19655	COG0534	Mate efflux family protein
FCL46_RS19660	COG1966	Carbon starvation protein
FCL46_RS19665	COG3275	phosphorelay sensor kinase activity
FCL46_RS19670	COG3279	Response regulator of the LytR AlgR family
FCL46_RS19705	COG0686	Belongs to the AlaDH PNT family
FCL46_RS19715	COG0028	Belongs to the TPP enzyme family
FCL46_RS19725	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FCL46_RS19730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL46_RS19735	COG2423	ornithine cyclodeaminase activity
FCL46_RS19750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FCL46_RS19770	COG0517	IMP dehydrogenase activity
FCL46_RS19855	COG0596	Alpha beta hydrolase
FCL46_RS19860	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FCL46_RS19885	COG1151	hydroxylamine reductase activity
FCL46_RS19890	COG2205	protein histidine kinase activity
FCL46_RS19890	COG0784	Response regulator, receiver
FCL46_RS19895	COG1049	propionate catabolic process, 2-methylcitrate cycle
FCL46_RS19920	COG3290	protein histidine kinase activity
FCL46_RS19925	COG4565	transcriptional regulatory protein
FCL46_RS19930	COG1321	iron dependent repressor
FCL46_RS19940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FCL46_RS19945	COG0484	heat shock protein binding
FCL46_RS19985	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FCL46_RS19990	COG0393	Putative heavy-metal-binding
FCL46_RS20015	COG0328	RNA-DNA hybrid ribonuclease activity
FCL46_RS20030	COG0343	queuine tRNA-ribosyltransferase activity
FCL46_RS20045	COG0837	glucose binding
FCL46_RS20055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FCL46_RS20055	COG0519	Catalyzes the synthesis of GMP from XMP
FCL46_RS20060	COG0516	GMP reductase activity
FCL46_RS20060	COG0517	IMP dehydrogenase activity
FCL46_RS20065	COG0009	L-threonylcarbamoyladenylate synthase
FCL46_RS20070	COG0776	regulation of translation
FCL46_RS20075	COG0539	negative regulation of cytoplasmic translation
FCL46_RS20080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FCL46_RS20085	COG0513	Belongs to the DEAD box helicase family
FCL46_RS20100	COG0129	dihydroxy-acid dehydratase activity
FCL46_RS20110	COG0674	pyruvate-flavodoxin oxidoreductase activity
FCL46_RS20110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FCL46_RS20140	COG0840	transmembrane signaling receptor activity
FCL46_RS20145	COG1466	dna polymerase III delta subunit
FCL46_RS20150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FCL46_RS20155	COG0542	response to heat
FCL46_RS20165	COG0537	adenosine 5'-monophosphoramidase activity
FCL46_RS20170	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FCL46_RS20175	COG1322	Protein conserved in bacteria
FCL46_RS20190	COG2204	response regulator
FCL46_RS20195	COG4191	Histidine kinase
FCL46_RS20210	COG0204	Acyl-transferase
FCL46_RS20210	COG0318	PFAM AMP-dependent synthetase and ligase
FCL46_RS20215	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FCL46_RS20230	COG2204	response regulator
FCL46_RS20235	COG3852	Histidine kinase
FCL46_RS20245	COG2264	protein methyltransferase activity
FCL46_RS20265	COG0765	amino acid transport
FCL46_RS20270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS20275	COG0765	amino acid transport
FCL46_RS20285	COG0864	Transcriptional regulator
FCL46_RS20310	COG3852	Histidine kinase
FCL46_RS20355	COG0149	triose-phosphate isomerase activity
FCL46_RS20360	COG0456	acetyltransferase
FCL46_RS20360	COG1214	PFAM Peptidase M22, glycoprotease
FCL46_RS20365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FCL46_RS20370	COG1489	DNA binding
FCL46_RS20375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FCL46_RS20380	COG0540	Belongs to the ATCase OTCase family
FCL46_RS20385	COG0681	Belongs to the peptidase S26 family
FCL46_RS20425	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FCL46_RS20430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FCL46_RS20435	COG1832	CoA-binding protein
FCL46_RS20440	COG0752	glycyl-tRNA synthetase alpha subunit
FCL46_RS20470	COG0800	Aldolase
FCL46_RS20475	COG3734	2-keto-3-deoxy-galactonokinase
FCL46_RS20480	COG4948	Mandelate Racemase Muconate Lactonizing
FCL46_RS20490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL46_RS20500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FCL46_RS20505	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FCL46_RS20510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FCL46_RS20520	COG0459	protein refolding
FCL46_RS20525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FCL46_RS20530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FCL46_RS20535	COG0628	permease
FCL46_RS20570	COG4294	response to UV
FCL46_RS20580	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FCL46_RS20590	COG1522	sequence-specific DNA binding
FCL46_RS20610	COG2205	protein histidine kinase activity
FCL46_RS20610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS20615	COG3033	Beta-eliminating lyase
FCL46_RS20645	COG1408	metallophosphoesterase
FCL46_RS20655	COG4628	conserved protein (DUF2132)
FCL46_RS20665	COG0101	tRNA pseudouridine synthase activity
FCL46_RS20685	COG2226	methyltransferase
FCL46_RS20710	COG1278	Cold shock
FCL46_RS20720	COG0148	phosphopyruvate hydratase activity
FCL46_RS20735	COG0501	Belongs to the peptidase M48B family
FCL46_RS20745	COG4221	oxidoreductase activity
FCL46_RS20765	COG1882	Formate acetyltransferase
FCL46_RS20770	COG0668	transmembrane transport
FCL46_RS20780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL46_RS20785	COG2249	NAD(P)H dehydrogenase (quinone) activity
FCL46_RS20795	COG3300	MHYT domain
FCL46_RS20795	COG5001	Diguanylate cyclase
FCL46_RS20810	COG3063	Type IV pilus biogenesis stability protein PilW
FCL46_RS20825	COG5002	protein histidine kinase activity
FCL46_RS20825	COG0784	Response regulator, receiver
FCL46_RS20825	COG2205	protein histidine kinase activity
FCL46_RS20835	COG0295	cytidine deaminase activity
FCL46_RS20840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FCL46_RS20875	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FCL46_RS20955	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
FCL46_RS20960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS20965	COG4597	amino acid ABC transporter
FCL46_RS20970	COG0765	amino acid transport
FCL46_RS20975	COG1126	abc transporter atp-binding protein
FCL46_RS20985	COG2186	Transcriptional regulator
FCL46_RS20990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FCL46_RS21005	COG1556	Lactate utilization protein
FCL46_RS21010	COG1139	Iron-sulfur cluster binding protein
FCL46_RS21050	COG1744	ABC transporter substrate-binding protein PnrA-like
FCL46_RS21080	COG3209	COG3209 Rhs family protein
FCL46_RS21095	COG3119	arylsulfatase activity
FCL46_RS21165	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FCL46_RS21170	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FCL46_RS21230	COG2909	trisaccharide binding
FCL46_RS21265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FCL46_RS21275	COG3021	interspecies interaction between organisms
FCL46_RS21285	COG0628	permease
FCL46_RS21300	COG1566	PFAM secretion protein HlyD family protein
FCL46_RS21320	COG2205	protein histidine kinase activity
FCL46_RS21320	COG2198	Histidine kinase
FCL46_RS21320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS21320	COG0784	Response regulator, receiver
FCL46_RS21350	COG1802	Transcriptional regulator
FCL46_RS21355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FCL46_RS21360	COG1882	Formate acetyltransferase
FCL46_RS21370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FCL46_RS21375	COG3639	organic phosphonate transmembrane transporter activity
FCL46_RS21380	COG3639	organic phosphonate transmembrane transporter activity
FCL46_RS21385	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FCL46_RS21440	COG0189	ligase activity
FCL46_RS21445	COG0372	Belongs to the citrate synthase family
FCL46_RS21450	COG2204	response regulator
FCL46_RS21455	COG0745	RESPONSE REGULATOR receiver
FCL46_RS21460	COG2205	protein histidine kinase activity
FCL46_RS21505	COG3385	transposase activity
FCL46_RS21520	COG1744	ABC transporter substrate-binding protein PnrA-like
FCL46_RS21530	COG4603	Belongs to the binding-protein-dependent transport system permease family
FCL46_RS21540	COG0402	S-adenosylhomocysteine deaminase activity
FCL46_RS21550	COG1032	radical SAM domain protein
FCL46_RS21560	COG1013	pyruvate-flavodoxin oxidoreductase activity
FCL46_RS21565	COG0674	pyruvate-flavodoxin oxidoreductase activity
FCL46_RS21575	COG0071	Belongs to the small heat shock protein (HSP20) family
FCL46_RS21600	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FCL46_RS21625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FCL46_RS21630	COG1022	Amp-dependent synthetase and ligase
FCL46_RS21665	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FCL46_RS21670	COG2186	Transcriptional regulator
FCL46_RS21680	COG0045	succinate-CoA ligase (ADP-forming) activity
FCL46_RS21680	COG1042	CoA-binding domain protein
FCL46_RS21680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FCL46_RS21685	COG0427	acetyl-CoA hydrolase
FCL46_RS21690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FCL46_RS21695	COG3272	Protein of unknown function (DUF1722)
FCL46_RS21700	COG3437	response regulator, receiver
FCL46_RS21700	COG0784	Response regulator, receiver
FCL46_RS21705	COG3848	Pyruvate phosphate dikinase
FCL46_RS21705	COG0574	Belongs to the PEP-utilizing enzyme family
FCL46_RS21740	COG0039	L-malate dehydrogenase activity
FCL46_RS21750	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FCL46_RS21760	COG0840	transmembrane signaling receptor activity
FCL46_RS21770	COG0277	FAD linked oxidase domain protein
FCL46_RS21775	COG0247	lactate metabolic process
FCL46_RS21890	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FCL46_RS21895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FCL46_RS21920	COG1129	ABC transporter
FCL46_RS21925	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FCL46_RS21935	COG0765	amino acid transport
FCL46_RS21950	COG0697	spore germination
FCL46_RS21955	COG2153	protein acetylation
FCL46_RS21960	COG2824	Alkylphosphonate utilization operon protein PhnA
FCL46_RS21965	COG0456	acetyltransferase
FCL46_RS21975	COG0850	regulation of cytokinetic process
FCL46_RS21980	COG2894	cell division
FCL46_RS21985	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FCL46_RS21995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FCL46_RS22030	COG2186	Transcriptional regulator
FCL46_RS22040	COG0730	response to heat
FCL46_RS22050	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FCL46_RS22065	COG0179	Fumarylacetoacetate (FAA) hydrolase
FCL46_RS22080	COG0471	metal ion transport
FCL46_RS22080	COG0490	domain, Protein
FCL46_RS22090	COG3243	poly(R)-hydroxyalkanoic acid synthase
FCL46_RS22095	COG0778	Nitroreductase
FCL46_RS22095	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FCL46_RS22120	COG1280	lysine exporter protein (LysE YggA)
FCL46_RS22135	COG4608	Belongs to the ABC transporter superfamily
FCL46_RS22140	COG0444	Belongs to the ABC transporter superfamily
FCL46_RS22145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FCL46_RS22150	COG0601	transmembrane transport
FCL46_RS22155	COG0747	negative chemotaxis
FCL46_RS22160	COG2233	PERMEase
FCL46_RS22165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FCL46_RS22185	COG3842	ATPase activity
FCL46_RS22200	COG0395	ABC-type sugar transport system, permease component
FCL46_RS22215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FCL46_RS22220	COG1620	l-lactate permease
FCL46_RS22225	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FCL46_RS22250	COG3040	lipid binding
FCL46_RS22255	COG1592	Rubrerythrin
FCL46_RS22260	COG4566	intracellular signal transduction
FCL46_RS22265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL46_RS22270	COG2274	protein secretion by the type I secretion system
FCL46_RS22290	COG1538	Outer membrane efflux protein
FCL46_RS22305	COG3321	synthase
FCL46_RS22305	COG1028	Short-chain dehydrogenase reductase Sdr
FCL46_RS22305	COG0604	alcohol dehydrogenase
FCL46_RS22315	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FCL46_RS22320	COG3437	response regulator, receiver
FCL46_RS22340	COG2358	TRAP transporter, solute receptor (TAXI family
FCL46_RS22345	COG0242	peptide deformylase activity
FCL46_RS22350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FCL46_RS22355	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
FCL46_RS22360	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FCL46_RS22365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FCL46_RS22395	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FCL46_RS22430	COG1305	Transglutaminase-like
FCL46_RS22440	COG0714	Associated with various cellular activities
FCL46_RS22500	COG1294	oxidase, subunit
FCL46_RS22505	COG1271	oxidase subunit
FCL46_RS22520	COG0347	Belongs to the P(II) protein family
FCL46_RS22525	COG0004	ammonium transporteR
FCL46_RS22535	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
FCL46_RS22540	COG0347	Belongs to the P(II) protein family
FCL46_RS22590	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FCL46_RS22630	COG0310	cobalt ion transport
FCL46_RS22635	COG0310	cobalt ion transport
FCL46_RS22650	COG1122	ATPase activity
FCL46_RS22655	COG3409	Peptidoglycan-binding domain 1 protein
FCL46_RS22655	COG3267	Type II secretory pathway component ExeA
FCL46_RS22670	COG0535	radical SAM domain protein
FCL46_RS22670	COG1433	Dinitrogenase iron-molybdenum cofactor
FCL46_RS22685	COG0427	acetyl-CoA hydrolase
FCL46_RS22690	COG0857	belongs to the CobB CobQ family
FCL46_RS22690	COG0280	phosphate acetyltransferase
FCL46_RS22700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FCL46_RS22715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FCL46_RS22735	COG0515	serine threonine protein kinase
FCL46_RS22735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FCL46_RS22750	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FCL46_RS22755	COG0745	RESPONSE REGULATOR receiver
FCL46_RS22760	COG2205	protein histidine kinase activity
FCL46_RS22790	COG1566	PFAM secretion protein HlyD family protein
FCL46_RS22810	COG1238	metal cluster binding
FCL46_RS22820	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS22830	COG2204	response regulator
FCL46_RS22835	COG1556	Lactate utilization protein
FCL46_RS22840	COG1139	Iron-sulfur cluster binding protein
FCL46_RS22865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FCL46_RS22895	COG1053	succinate dehydrogenase
FCL46_RS22900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FCL46_RS22905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FCL46_RS22920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FCL46_RS22950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FCL46_RS22970	COG1028	Short-chain dehydrogenase reductase Sdr
FCL46_RS22995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FCL46_RS23005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FCL46_RS23045	COG0784	Response regulator, receiver
FCL46_RS23045	COG2198	Histidine kinase
FCL46_RS23045	COG5002	protein histidine kinase activity
FCL46_RS23065	COG2080	2 iron, 2 sulfur cluster binding
FCL46_RS23065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FCL46_RS23070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FCL46_RS23075	COG2068	MobA-Related Protein
FCL46_RS23080	COG3608	succinylglutamate desuccinylase aspartoacylase
FCL46_RS23080	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FCL46_RS23085	COG3608	succinylglutamate desuccinylase aspartoacylase
FCL46_RS23085	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FCL46_RS23095	COG1047	Peptidyl-prolyl cis-trans
FCL46_RS23110	COG0012	GTP binding
FCL46_RS23135	COG0047	phosphoribosylformylglycinamidine synthase activity
FCL46_RS23135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FCL46_RS23160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FCL46_RS23165	COG1120	ATPase activity
FCL46_RS23175	COG0640	Transcriptional regulator
FCL46_RS23180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FCL46_RS23185	COG0798	PFAM Bile acid sodium symporter
FCL46_RS23200	COG1739	Uncharacterized protein family UPF0029
FCL46_RS23230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FCL46_RS23260	COG0514	ATP-dependent DNA helicase (RecQ)
FCL46_RS23295	COG0653	protein targeting
FCL46_RS23320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FCL46_RS23415	COG0494	nUDIX hydrolase
FCL46_RS23440	COG1401	restriction endodeoxyribonuclease activity
FCL46_RS23465	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FCL46_RS23470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FCL46_RS23475	COG1205	dead DEAH box helicase
FCL46_RS23475	COG1111	helicase
FCL46_RS23480	COG2814	Major facilitator Superfamily
FCL46_RS23490	COG2814	Major facilitator Superfamily
FCL46_RS23495	COG0076	glutamate decarboxylase activity
FCL46_RS23500	COG0251	oxidation-reduction process
FCL46_RS23505	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FCL46_RS23510	COG1301	dicarboxylic acid transport
FCL46_RS23515	COG1802	Transcriptional regulator
FCL46_RS23565	COG4279	zinc finger
FCL46_RS23570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FCL46_RS23595	COG0069	glutamate synthase activity
FCL46_RS23605	COG0584	glycerophosphoryl diester phosphodiesterase
FCL46_RS23610	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FCL46_RS23625	COG0318	PFAM AMP-dependent synthetase and ligase
FCL46_RS23655	COG2197	response regulator
FCL46_RS23695	COG4251	negative regulation of phosphorylation
FCL46_RS23695	COG3706	GGDEF domain
FCL46_RS23695	COG2203	Gaf domain
FCL46_RS23695	COG5001	Diguanylate cyclase
FCL46_RS23735	COG2308	Evidence 4 Homologs of previously reported genes of
FCL46_RS23770	COG1085	galactose-1-phosphate uridylyltransferase
FCL46_RS23775	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FCL46_RS23785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FCL46_RS23805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FCL46_RS23810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FCL46_RS23815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FCL46_RS23820	COG0183	Belongs to the thiolase family
FCL46_RS23830	COG1122	ATPase activity
FCL46_RS23850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FCL46_RS23865	COG1129	ABC transporter
FCL46_RS23880	COG4608	Belongs to the ABC transporter superfamily
FCL46_RS23885	COG1136	(ABC) transporter
FCL46_RS23885	COG0577	efflux transmembrane transporter activity
FCL46_RS23890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FCL46_RS23895	COG0601	transmembrane transport
FCL46_RS23915	COG3622	Belongs to the hyi family
FCL46_RS23920	COG2084	Dehydrogenase
FCL46_RS23940	COG1858	cytochrome C peroxidase
FCL46_RS23965	COG3011	Protein conserved in bacteria
FCL46_RS23985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FCL46_RS24020	COG4974	Belongs to the 'phage' integrase family
FCL46_RS24045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FCL46_RS24050	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FCL46_RS24065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FCL46_RS24070	COG0045	succinate-CoA ligase (ADP-forming) activity
FCL46_RS24080	COG1013	pyruvate-flavodoxin oxidoreductase activity
FCL46_RS24085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FCL46_RS24085	COG0674	pyruvate-flavodoxin oxidoreductase activity
FCL46_RS24100	COG0679	Auxin Efflux Carrier
FCL46_RS24105	COG0028	Belongs to the TPP enzyme family
FCL46_RS24120	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FCL46_RS24130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FCL46_RS24135	COG1414	Transcriptional regulator
FCL46_RS24140	COG0741	lytic transglycosylase activity
FCL46_RS24145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FCL46_RS24155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FCL46_RS24160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FCL46_RS24165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FCL46_RS24170	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FCL46_RS24180	COG0165	Argininosuccinate lyase
FCL46_RS24185	COG0137	argininosuccinate synthase activity
FCL46_RS24190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FCL46_RS24195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FCL46_RS24200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FCL46_RS24210	COG1137	ATPase activity
FCL46_RS24245	COG2363	Small membrane protein
FCL46_RS24250	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FCL46_RS24255	COG1215	transferase activity, transferring glycosyl groups
FCL46_RS24270	COG0745	RESPONSE REGULATOR receiver
FCL46_RS24275	COG2770	Histidine kinase
FCL46_RS24275	COG2205	protein histidine kinase activity
FCL46_RS24325	COG0745	RESPONSE REGULATOR receiver
FCL46_RS24330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FCL46_RS24340	COG1132	(ABC) transporter
FCL46_RS24360	COG1752	Esterase of the alpha-beta hydrolase superfamily
FCL46_RS24365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FCL46_RS24380	COG0489	protein tyrosine kinase activity
FCL46_RS24385	COG0489	protein tyrosine kinase activity
FCL46_RS24390	COG2920	part of a sulfur-relay system
FCL46_RS24395	COG2226	methyltransferase
FCL46_RS24400	COG0714	Associated with various cellular activities
FCL46_RS24435	COG2703	oxygen carrier activity
FCL46_RS24445	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FCL46_RS24455	COG2264	protein methyltransferase activity
FCL46_RS24475	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FCL46_RS24485	COG0583	DNA-binding transcription factor activity
FCL46_RS24505	COG1333	cytochrome c biogenesis protein
FCL46_RS24510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FCL46_RS24530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FCL46_RS24540	COG2954	triphosphatase activity
FCL46_RS24545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FCL46_RS24550	COG2003	Belongs to the UPF0758 family
FCL46_RS24555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FCL46_RS24600	COG1192	Involved in chromosome partitioning
FCL46_RS24605	COG1475	DNA binding
FCL46_RS24610	COG4991	sh3 domain protein
FCL46_RS24610	COG3103	Sh3 type 3 domain protein
FCL46_RS24610	COG0860	N-Acetylmuramoyl-L-alanine amidase
FCL46_RS24630	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FCL46_RS24635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FCL46_RS24640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FCL46_RS24645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FCL46_RS24650	COG0187	DNA topoisomerase II activity
FCL46_RS24655	COG0592	DNA-directed DNA polymerase activity
FCL46_RS24660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FCL46_RS24680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FCL46_RS24680	COG0425	Belongs to the sulfur carrier protein TusA family
FCL46_RS24685	COG2391	methyltransferase activity
FCL46_RS24695	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FCL46_RS24700	COG0154	amidase activity
FCL46_RS24705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FCL46_RS24710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FCL46_RS24715	COG2885	chlorophyll binding
FCL46_RS24725	COG0116	Belongs to the methyltransferase superfamily
FCL46_RS24725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FCL46_RS24745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FCL46_RS24765	COG4191	Histidine kinase
FCL46_RS24775	COG1720	tRNA m6t6A37 methyltransferase activity
FCL46_RS24785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FCL46_RS24790	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FCL46_RS24795	COG0504	CTP synthase activity
FCL46_RS24800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FCL46_RS24800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FCL46_RS24820	COG2321	neutral zinc metallopeptidase
FCL46_RS24840	COG4771	TonB-dependent receptor
FCL46_RS24845	COG0010	Belongs to the arginase family
FCL46_RS24860	COG1166	arginine decarboxylase activity
FCL46_RS24870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FCL46_RS24870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FCL46_RS24875	COG2205	protein histidine kinase activity
FCL46_RS24880	COG0745	RESPONSE REGULATOR receiver
FCL46_RS24885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FCL46_RS24900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FCL46_RS24925	COG0789	Transcriptional regulator
FCL46_RS24960	COG2203	Gaf domain
FCL46_RS24960	COG4251	negative regulation of phosphorylation
FCL46_RS24960	COG5001	Diguanylate cyclase
FCL46_RS24960	COG3706	GGDEF domain
FCL46_RS24995	COG1136	(ABC) transporter
FCL46_RS24995	COG0577	efflux transmembrane transporter activity
FCL46_RS25005	COG1136	(ABC) transporter
FCL46_RS25025	COG1012	belongs to the aldehyde dehydrogenase family
FCL46_RS25025	COG1454	alcohol dehydrogenase
FCL46_RS25040	COG4869	propanediol catabolic process
FCL46_RS25050	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
FCL46_RS25060	COG4656	Part of a membrane complex involved in electron transport
FCL46_RS25070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FCL46_RS25075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FCL46_RS25085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FCL46_RS25125	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FCL46_RS25140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FCL46_RS25155	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FCL46_RS25160	COG0511	ligase activity, forming carbon-carbon bonds
FCL46_RS25175	COG2304	oxidoreductase activity
FCL46_RS25190	COG0284	orotidine-5'-phosphate decarboxylase activity
FCL46_RS25205	COG2186	Transcriptional regulator
FCL46_RS25220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FCL46_RS25260	COG1151	hydroxylamine reductase activity
FCL46_RS25265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FCL46_RS25265	COG0617	tRNA 3'-terminal CCA addition
FCL46_RS25265	COG0517	IMP dehydrogenase activity
FCL46_RS25270	COG1556	Lactate utilization protein
FCL46_RS25275	COG1139	Iron-sulfur cluster binding protein
FCL46_RS25280	COG0247	lactate metabolic process
FCL46_RS25285	COG3604	Transcriptional regulator
FCL46_RS25295	COG0655	NAD(P)H dehydrogenase (quinone) activity
FCL46_RS25370	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FCL46_RS25385	COG1132	(ABC) transporter
FCL46_RS25385	COG1132	(ABC) transporter
FCL46_RS25400	COG1366	Belongs to the anti-sigma-factor antagonist family
FCL46_RS25420	COG3706	GGDEF domain
FCL46_RS25425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FCL46_RS25430	COG2195	Cleaves the N-terminal amino acid of tripeptides
FCL46_RS25435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FCL46_RS25435	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FCL46_RS25450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FCL46_RS25465	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FCL46_RS25470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FCL46_RS25475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FCL46_RS25500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FCL46_RS25515	COG0784	Response regulator, receiver
FCL46_RS25515	COG2198	Histidine kinase
FCL46_RS25515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS25515	COG2205	protein histidine kinase activity
FCL46_RS25530	COG1671	Belongs to the UPF0178 family
FCL46_RS25550	COG0569	domain protein
FCL46_RS25560	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FCL46_RS25570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FCL46_RS25580	COG2239	Acts as a magnesium transporter
FCL46_RS25605	COG2153	protein acetylation
FCL46_RS25610	COG0589	response to stress
FCL46_RS25640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FCL46_RS25645	COG1773	rubredoxin
FCL46_RS25655	COG1610	YqeY-like protein
FCL46_RS25660	COG0277	FAD linked oxidase domain protein
FCL46_RS25670	COG0601	transmembrane transport
FCL46_RS25675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FCL46_RS25680	COG0444	Belongs to the ABC transporter superfamily
FCL46_RS25685	COG4608	Belongs to the ABC transporter superfamily
FCL46_RS25720	COG1484	DNA-dependent DNA replication
FCL46_RS25725	COG4584	PFAM Integrase catalytic
FCL46_RS25735	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
FCL46_RS25740	COG3259	Nickel-dependent hydrogenase
FCL46_RS25750	COG0519	Catalyzes the synthesis of GMP from XMP
FCL46_RS25760	COG3273	potassium ion transport
FCL46_RS25760	COG0471	metal ion transport
FCL46_RS25765	COG3961	Belongs to the TPP enzyme family
FCL46_RS25770	COG4822	anaerobic cobalamin biosynthetic process
FCL46_RS25785	COG3279	Response regulator of the LytR AlgR family
FCL46_RS25790	COG3275	phosphorelay sensor kinase activity
FCL46_RS25805	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FCL46_RS25810	COG0280	phosphate acetyltransferase
FCL46_RS25810	COG0857	belongs to the CobB CobQ family
FCL46_RS25815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FCL46_RS25840	COG0778	Nitroreductase
FCL46_RS25840	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FCL46_RS25870	COG2208	phosphoserine phosphatase activity
FCL46_RS25875	COG1448	Aminotransferase
FCL46_RS25940	COG0351	phosphomethylpyrimidine kinase
FCL46_RS25955	COG1454	alcohol dehydrogenase
FCL46_RS25960	COG0028	Belongs to the TPP enzyme family
FCL46_RS25965	COG0440	acetolactate synthase activity
FCL46_RS25970	COG1278	Cold shock
FCL46_RS25980	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FCL46_RS25985	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FCL46_RS26010	COG4670	ketone body catabolic process
FCL46_RS26015	COG1028	Short-chain dehydrogenase reductase Sdr
FCL46_RS26020	COG0183	Belongs to the thiolase family
FCL46_RS26045	COG0826	peptidase U32
FCL46_RS26055	COG4974	Belongs to the 'phage' integrase family
FCL46_RS26120	COG2095	MarC family integral membrane protein
FCL46_RS26155	COG0412	Dienelactone hydrolase
FCL46_RS26160	COG0641	radical SAM
FCL46_RS26170	COG3576	pyridoxamine 5-phosphate
FCL46_RS26175	COG1959	2 iron, 2 sulfur cluster binding
FCL46_RS26180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FCL46_RS26195	COG1902	pentaerythritol trinitrate reductase activity
FCL46_RS26205	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FCL46_RS26210	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FCL46_RS26215	COG3639	organic phosphonate transmembrane transporter activity
FCL46_RS26250	COG0489	protein tyrosine kinase activity
FCL46_RS26260	COG0484	heat shock protein binding
FCL46_RS26305	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS26310	COG0463	Glycosyl transferase, family 2
FCL46_RS26315	COG2264	protein methyltransferase activity
FCL46_RS26325	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS26325	COG0297	glycogen (starch) synthase activity
FCL46_RS26330	COG0367	asparagine synthase
FCL46_RS26335	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS26340	COG0667	Aldo Keto reductase
FCL46_RS26345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FCL46_RS26350	COG0589	response to stress
FCL46_RS26365	COG1690	Belongs to the RtcB family
FCL46_RS26370	COG4650	regulator
FCL46_RS26385	COG3008	intermembrane lipid transfer
FCL46_RS26390	COG2995	paraquat-inducible protein a
FCL46_RS26415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FCL46_RS26425	COG1522	sequence-specific DNA binding
FCL46_RS26435	COG0508	dehydrogenase complex catalyzes the overall conversion of
FCL46_RS26440	COG1272	protein, Hemolysin III
FCL46_RS26445	COG0840	transmembrane signaling receptor activity
FCL46_RS26455	COG2084	Dehydrogenase
FCL46_RS26470	COG3852	Histidine kinase
FCL46_RS26480	COG0243	molybdopterin cofactor binding
FCL46_RS26490	COG0437	4 iron, 4 sulfur cluster binding
FCL46_RS26495	COG0348	domain, Protein
FCL46_RS26505	COG2832	Protein of unknown function (DUF454)
FCL46_RS26510	COG3681	Belongs to the UPF0597 family
FCL46_RS26515	COG0251	oxidation-reduction process
FCL46_RS26530	COG2719	SpoVR family
FCL46_RS26540	COG4822	anaerobic cobalamin biosynthetic process
FCL46_RS26560	COG5002	protein histidine kinase activity
FCL46_RS26570	COG0181	hydroxymethylbilane synthase activity
FCL46_RS26585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FCL46_RS26590	COG3620	sequence-specific DNA binding
FCL46_RS26600	COG0277	FAD linked oxidase domain protein
FCL46_RS26650	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FCL46_RS26655	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
FCL46_RS26660	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FCL46_RS26665	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FCL46_RS26670	COG0617	tRNA 3'-terminal CCA addition
FCL46_RS26675	COG2070	2-Nitropropane dioxygenase
FCL46_RS26680	COG0124	histidyl-tRNA synthetase
FCL46_RS26685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FCL46_RS26700	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FCL46_RS26735	COG1643	Atp-dependent helicase
FCL46_RS26750	COG0167	dihydroorotate dehydrogenase activity
FCL46_RS26755	COG4656	Part of a membrane complex involved in electron transport
FCL46_RS26760	COG4658	electron transport chain
FCL46_RS26765	COG4659	FMN binding
FCL46_RS26770	COG4660	Part of a membrane complex involved in electron transport
FCL46_RS26775	COG4657	Part of a membrane complex involved in electron transport
FCL46_RS26780	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
FCL46_RS26780	COG2878	Part of a membrane complex involved in electron transport
FCL46_RS26805	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS26820	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FCL46_RS26840	COG1477	protein flavinylation
FCL46_RS26850	COG0656	L-ascorbic acid biosynthetic process
FCL46_RS26855	COG1794	racemase activity, acting on amino acids and derivatives
FCL46_RS26860	COG0697	spore germination
FCL46_RS26865	COG1119	ATPase activity
FCL46_RS26875	COG1607	acyl-coa hydrolase
FCL46_RS26885	COG0697	spore germination
FCL46_RS26890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FCL46_RS26895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FCL46_RS26925	COG0730	response to heat
FCL46_RS26940	COG2186	Transcriptional regulator
FCL46_RS26970	COG3360	Dodecin
FCL46_RS26980	COG1733	regulation of RNA biosynthetic process
FCL46_RS26985	COG0655	NAD(P)H dehydrogenase (quinone) activity
FCL46_RS27015	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FCL46_RS27020	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FCL46_RS27055	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FCL46_RS27060	COG0483	inositol monophosphate 1-phosphatase activity
FCL46_RS27065	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FCL46_RS27070	COG1053	succinate dehydrogenase
FCL46_RS27075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FCL46_RS27090	COG0617	tRNA 3'-terminal CCA addition
FCL46_RS27090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FCL46_RS27090	COG3620	sequence-specific DNA binding
FCL46_RS27105	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FCL46_RS27110	COG0006	proline dipeptidase activity
FCL46_RS27120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FCL46_RS27120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FCL46_RS27125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL46_RS27145	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FCL46_RS27155	COG4574	serine-type endopeptidase inhibitor activity
FCL46_RS27175	COG0110	maltose O-acetyltransferase activity
FCL46_RS27185	COG0367	asparagine synthase
FCL46_RS27200	COG2192	nodulation
FCL46_RS27205	COG2755	lipolytic protein G-D-S-L family
FCL46_RS27205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FCL46_RS27230	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FCL46_RS27230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FCL46_RS27235	COG1063	alcohol dehydrogenase
FCL46_RS27240	COG1105	Belongs to the carbohydrate kinase PfkB family
FCL46_RS27245	COG0191	fructose-bisphosphate aldolase activity
FCL46_RS27255	COG0148	phosphopyruvate hydratase activity
FCL46_RS27260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FCL46_RS27305	COG2204	response regulator
FCL46_RS27315	COG2205	protein histidine kinase activity
FCL46_RS27315	COG4191	Histidine kinase
FCL46_RS27315	COG0745	RESPONSE REGULATOR receiver
FCL46_RS27335	COG2205	protein histidine kinase activity
FCL46_RS27345	COG0438	transferase activity, transferring glycosyl groups
FCL46_RS27355	COG1752	Esterase of the alpha-beta hydrolase superfamily
FCL46_RS27375	COG0071	Belongs to the small heat shock protein (HSP20) family
FCL46_RS27415	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FCL46_RS27435	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FCL46_RS27440	COG2315	Protein conserved in bacteria
FCL46_RS27445	COG1592	Rubrerythrin
FCL46_RS27470	COG1490	D-aminoacyl-tRNA deacylase activity
FCL46_RS27490	COG2204	response regulator
FCL46_RS27495	COG5002	protein histidine kinase activity
FCL46_RS27500	COG1846	Transcriptional regulator
FCL46_RS27520	COG4662	Binding-protein-dependent transport system inner membrane component
FCL46_RS27570	COG2205	protein histidine kinase activity
FCL46_RS27575	COG0745	RESPONSE REGULATOR receiver
FCL46_RS27585	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FCL46_RS27585	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FCL46_RS27590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FCL46_RS27600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FCL46_RS27605	COG4134	Bacterial extracellular solute-binding protein
FCL46_RS27610	COG4135	transport system, permease component
FCL46_RS27615	COG4136	ATPase activity
FCL46_RS27620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FCL46_RS27630	COG3409	Peptidoglycan-binding domain 1 protein
FCL46_RS27630	COG3267	Type II secretory pathway component ExeA
FCL46_RS27650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FCL46_RS27655	COG0509	glycine decarboxylation via glycine cleavage system
FCL46_RS27660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FCL46_RS27665	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FCL46_RS27670	COG0321	lipoyl(octanoyl) transferase activity
FCL46_RS27675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FCL46_RS27710	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FCL46_RS27730	COG1473	amidohydrolase
FCL46_RS27745	COG0429	hydrolase of the alpha beta-hydrolase fold
FCL46_RS27765	COG3132	Protein of unknown function, DUF480
FCL46_RS27770	COG2897	thiosulfate sulfurtransferase activity
FCL46_RS27775	COG2186	Transcriptional regulator
FCL46_RS27800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FCL46_RS27815	COG2270	Major facilitator Superfamily
FCL46_RS27880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FCL46_RS27885	COG0584	glycerophosphoryl diester phosphodiesterase
FCL46_RS27890	COG1011	Hydrolase
FCL46_RS27900	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FCL46_RS27905	COG1040	competence protein