locus-tag	class	description
DP_RS00015	COG1234	tRNA 3'-trailer cleavage
DP_RS00025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DP_RS00035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DP_RS00045	COG2852	Protein conserved in bacteria
DP_RS00070	COG2755	lipolytic protein G-D-S-L family
DP_RS00070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DP_RS00090	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DP_RS00095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DP_RS00105	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DP_RS00115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DP_RS00120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DP_RS00130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DP_RS00135	COG0438	transferase activity, transferring glycosyl groups
DP_RS00140	COG0438	transferase activity, transferring glycosyl groups
DP_RS00145	COG0367	asparagine synthase
DP_RS00200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DP_RS00205	COG1088	dTDP-glucose 4,6-dehydratase activity
DP_RS00215	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DP_RS00245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DP_RS00260	COG1181	Belongs to the D-alanine--D-alanine ligase family
DP_RS00265	COG0277	FAD linked oxidase domain protein
DP_RS00275	COG0617	tRNA 3'-terminal CCA addition
DP_RS00275	COG3620	sequence-specific DNA binding
DP_RS00275	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DP_RS00280	COG1994	Peptidase M50
DP_RS00295	COG1328	CTP reductase activity
DP_RS00295	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DP_RS00300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DP_RS00310	COG1022	Amp-dependent synthetase and ligase
DP_RS00335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DP_RS00350	COG1217	gtp-binding protein TYPA
DP_RS00360	COG0702	epimerase
DP_RS00365	COG3122	Protein conserved in bacteria
DP_RS00375	COG1132	(ABC) transporter
DP_RS00380	COG1132	(ABC) transporter
DP_RS00415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DP_RS00425	COG0204	Acyl-transferase
DP_RS00425	COG0318	PFAM AMP-dependent synthetase and ligase
DP_RS00430	COG0765	amino acid transport
DP_RS00435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DP_RS00440	COG0765	amino acid transport
DP_RS00450	COG0864	Transcriptional regulator
DP_RS00475	COG1757	Na H antiporter
DP_RS00495	COG0149	triose-phosphate isomerase activity
DP_RS00500	COG0126	phosphoglycerate kinase activity
DP_RS00510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DP_RS00515	COG1489	DNA binding
DP_RS00520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DP_RS00525	COG0540	Belongs to the ATCase OTCase family
DP_RS00560	COG1450	Type ii and iii secretion system protein
DP_RS00570	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DP_RS00575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DP_RS00580	COG1832	CoA-binding protein
DP_RS00585	COG0752	glycyl-tRNA synthetase alpha subunit
DP_RS00600	COG1490	D-aminoacyl-tRNA deacylase activity
DP_RS00635	COG0006	proline dipeptidase activity
DP_RS00645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DP_RS00650	COG3620	sequence-specific DNA binding
DP_RS00650	COG0617	tRNA 3'-terminal CCA addition
DP_RS00650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DP_RS00655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DP_RS00670	COG0640	Transcriptional regulator
DP_RS00690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DP_RS00695	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DP_RS00725	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DP_RS00735	COG0528	UMP kinase activity
DP_RS00750	COG0601	transmembrane transport
DP_RS00755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DP_RS00760	COG0444	Belongs to the ABC transporter superfamily
DP_RS00765	COG4608	Belongs to the ABC transporter superfamily
DP_RS00770	COG1607	acyl-coa hydrolase
DP_RS00780	COG1566	PFAM secretion protein HlyD family protein
DP_RS00785	COG2814	Major facilitator Superfamily
DP_RS00820	COG0659	secondary active sulfate transmembrane transporter activity
DP_RS00830	COG0519	Catalyzes the synthesis of GMP from XMP
DP_RS00835	COG0720	synthase
DP_RS00840	COG0602	queuosine metabolic process
DP_RS00845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DP_RS00850	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DP_RS00850	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DP_RS00895	COG0582	viral genome integration into host DNA
DP_RS00930	COG1203	CRISPR-associated helicase, Cas3
DP_RS00955	COG0459	protein refolding
DP_RS00960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DP_RS00965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DP_RS00970	COG0628	permease
DP_RS00975	COG1592	Rubrerythrin
DP_RS00980	COG0789	Transcriptional regulator
DP_RS00990	COG0731	radical SAM domain protein
DP_RS00990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DP_RS01035	COG4175	Glycine betaine
DP_RS01040	COG4176	ABC-type proline glycine betaine transport system permease component
DP_RS01045	COG2113	Glycine betaine
DP_RS01055	COG0668	transmembrane transport
DP_RS01065	COG4822	anaerobic cobalamin biosynthetic process
DP_RS01080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DP_RS01085	COG1120	ATPase activity
DP_RS01095	COG1797	cobyrinic acid a,c-diamide synthase activity
DP_RS01105	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DP_RS01155	COG0387	Pfam Sodium calcium exchanger
DP_RS01160	COG0688	phosphatidylethanolamine metabolic process
DP_RS01165	COG2996	Protein conserved in bacteria
DP_RS01245	COG0318	PFAM AMP-dependent synthetase and ligase
DP_RS01255	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DP_RS01260	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DP_RS01265	COG1169	isochorismate synthase
DP_RS01280	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DP_RS01280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DP_RS01285	COG2195	Cleaves the N-terminal amino acid of tripeptides
DP_RS01290	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DP_RS01310	COG3608	succinylglutamate desuccinylase aspartoacylase
DP_RS01310	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DP_RS01315	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DP_RS01340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DP_RS01340	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DP_RS01355	COG0492	ferredoxin-NADP+ reductase activity
DP_RS01360	COG1238	metal cluster binding
DP_RS01365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DP_RS01375	COG0326	Molecular chaperone. Has ATPase activity
DP_RS01385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DP_RS01395	COG1040	competence protein
DP_RS01400	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DP_RS01410	COG1011	Hydrolase
DP_RS01415	COG0045	succinate-CoA ligase (ADP-forming) activity
DP_RS01420	COG0584	glycerophosphoryl diester phosphodiesterase
DP_RS01425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DP_RS01450	COG2356	endonuclease I
DP_RS01455	COG0840	transmembrane signaling receptor activity
DP_RS01475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DP_RS01480	COG0321	lipoyl(octanoyl) transferase activity
DP_RS01485	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DP_RS01490	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DP_RS01495	COG0509	glycine decarboxylation via glycine cleavage system
DP_RS01500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DP_RS01555	COG3706	GGDEF domain
DP_RS01555	COG4251	negative regulation of phosphorylation
DP_RS01555	COG5001	Diguanylate cyclase
DP_RS01555	COG2203	Gaf domain
DP_RS01560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DP_RS01565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DP_RS01570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DP_RS01575	COG4136	ATPase activity
DP_RS01595	COG4135	transport system, permease component
DP_RS01600	COG4134	Bacterial extracellular solute-binding protein
DP_RS01610	COG0004	ammonium transporteR
DP_RS01615	COG0347	Belongs to the P(II) protein family
DP_RS01630	COG4662	Binding-protein-dependent transport system inner membrane component
DP_RS01655	COG0584	glycerophosphoryl diester phosphodiesterase
DP_RS01705	COG3005	denitrification pathway
DP_RS01710	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
DP_RS01715	COG1119	ATPase activity
DP_RS01720	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DP_RS01750	COG1027	Aspartate ammonia-lyase
DP_RS01755	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DP_RS01780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DP_RS01785	COG3022	response to hydroperoxide
DP_RS01805	COG0023	Translation Initiation Factor
DP_RS01810	COG1278	Cold shock
DP_RS01850	COG2208	phosphoserine phosphatase activity
DP_RS01860	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DP_RS01880	COG3852	Histidine kinase
DP_RS01885	COG2204	response regulator
DP_RS01900	COG1172	Belongs to the binding-protein-dependent transport system permease family
DP_RS01915	COG0589	response to stress
DP_RS01920	COG0730	response to heat
DP_RS01925	COG0076	glutamate decarboxylase activity
DP_RS01930	COG2985	domain, Protein
DP_RS01940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DP_RS01960	COG0861	Integral membrane protein TerC family
DP_RS01980	COG1451	nucleotide metabolic process
DP_RS02020	COG0514	ATP-dependent DNA helicase (RecQ)
DP_RS02050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DP_RS02060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DP_RS02110	COG0582	viral genome integration into host DNA
DP_RS02125	COG0741	lytic transglycosylase activity
DP_RS02130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DP_RS02140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DP_RS02145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DP_RS02150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DP_RS02155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DP_RS02165	COG0165	Argininosuccinate lyase
DP_RS02170	COG0137	argininosuccinate synthase activity
DP_RS02175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DP_RS02180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DP_RS02185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DP_RS02200	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DP_RS02240	COG0527	aspartate kinase activity
DP_RS02245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DP_RS02255	COG1473	amidohydrolase
DP_RS02260	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DP_RS02275	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DP_RS02280	COG1187	pseudouridine synthase activity
DP_RS02285	COG4145	pantothenate transmembrane transporter activity
DP_RS02315	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DP_RS02325	COG4191	Histidine kinase
DP_RS02330	COG2204	response regulator
DP_RS02365	COG2204	response regulator
DP_RS02370	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DP_RS02380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DP_RS02385	COG3383	formate dehydrogenase (NAD+) activity
DP_RS02390	COG3383	formate dehydrogenase (NAD+) activity
DP_RS02400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DP_RS02405	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DP_RS02415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DP_RS02420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DP_RS02420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DP_RS02430	COG0251	oxidation-reduction process
DP_RS02450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DP_RS02470	COG2226	methyltransferase
DP_RS02475	COG0309	Hydrogenase expression formation protein (HypE)
DP_RS02490	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DP_RS02495	COG1116	anion transmembrane transporter activity
DP_RS02500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DP_RS02505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DP_RS02515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DP_RS02520	COG0069	glutamate synthase activity
DP_RS02535	COG1280	lysine exporter protein (LysE YggA)
DP_RS02560	COG2197	response regulator
DP_RS02585	COG1061	Type III restriction enzyme res subunit
DP_RS02600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DP_RS02610	COG0501	Belongs to the peptidase M48B family
DP_RS02615	COG0419	ATPase involved in DNA repair
DP_RS02625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DP_RS02630	COG1854	S-ribosylhomocysteine lyase activity
DP_RS02645	COG0386	Belongs to the glutathione peroxidase family
DP_RS02675	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DP_RS02685	COG0686	Belongs to the AlaDH PNT family
DP_RS02690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DP_RS02695	COG1454	alcohol dehydrogenase
DP_RS02705	COG0686	Belongs to the AlaDH PNT family
DP_RS02710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DP_RS02715	COG1454	alcohol dehydrogenase
DP_RS02740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DP_RS02765	COG0318	PFAM AMP-dependent synthetase and ligase
DP_RS02780	COG0280	phosphate acetyltransferase
DP_RS02780	COG0857	belongs to the CobB CobQ family
DP_RS02785	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DP_RS02790	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DP_RS02795	COG0725	ABC transporter, periplasmic molybdate-binding protein
DP_RS02805	COG3842	ATPase activity
DP_RS02815	COG1546	Belongs to the CinA family
DP_RS02815	COG1058	Belongs to the CinA family
DP_RS02840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DP_RS02845	COG0124	histidyl-tRNA synthetase
DP_RS02865	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DP_RS02870	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DP_RS02880	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DP_RS02900	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DP_RS02950	COG3681	Belongs to the UPF0597 family
DP_RS02960	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DP_RS02965	COG0501	Belongs to the peptidase M48B family
DP_RS02970	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DP_RS02970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DP_RS02975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DP_RS02975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DP_RS02995	COG5002	protein histidine kinase activity
DP_RS03000	COG0181	hydroxymethylbilane synthase activity
DP_RS03070	COG1448	Aminotransferase
DP_RS03085	COG0438	transferase activity, transferring glycosyl groups
DP_RS03100	COG0826	peptidase U32
DP_RS03125	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DP_RS03140	COG3300	MHYT domain
DP_RS03140	COG5001	Diguanylate cyclase
DP_RS03155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DP_RS03165	COG0714	Associated with various cellular activities
DP_RS03200	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DP_RS03205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DP_RS03210	COG0154	amidase activity
DP_RS03215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DP_RS03220	COG3437	response regulator, receiver
DP_RS03225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DP_RS03235	COG0592	DNA-directed DNA polymerase activity
DP_RS03240	COG0187	DNA topoisomerase II activity
DP_RS03245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DP_RS03250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DP_RS03260	COG2853	Lipoprotein
DP_RS03280	COG4221	oxidoreductase activity
DP_RS03290	COG0427	acetyl-CoA hydrolase
DP_RS03295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DP_RS03300	COG0039	L-malate dehydrogenase activity
DP_RS03305	COG4807	Protein conserved in bacteria
DP_RS03325	COG0850	regulation of cytokinetic process
DP_RS03330	COG2894	cell division
DP_RS03335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DP_RS03340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DP_RS03355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DP_RS03365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DP_RS03380	COG4603	Belongs to the binding-protein-dependent transport system permease family
DP_RS03385	COG1079	Belongs to the binding-protein-dependent transport system permease family
DP_RS03390	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DP_RS03395	COG3845	ABC transporter
DP_RS03400	COG3383	formate dehydrogenase (NAD+) activity
DP_RS03405	COG3383	formate dehydrogenase (NAD+) activity
DP_RS03425	COG0511	ligase activity, forming carbon-carbon bonds
DP_RS03430	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DP_RS03435	COG3008	intermembrane lipid transfer
DP_RS03440	COG2995	paraquat-inducible protein a
DP_RS03460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DP_RS03465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DP_RS03495	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DP_RS03520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DP_RS03525	COG1739	Uncharacterized protein family UPF0029
DP_RS03535	COG0047	phosphoribosylformylglycinamidine synthase activity
DP_RS03535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DP_RS03545	COG1115	amino acid carrier protein
DP_RS03550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DP_RS03555	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DP_RS03580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DP_RS03595	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DP_RS03600	COG2003	Belongs to the UPF0758 family
DP_RS03605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DP_RS03610	COG2954	triphosphatase activity
DP_RS03620	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DP_RS03635	COG0284	orotidine-5'-phosphate decarboxylase activity
DP_RS03640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DP_RS03645	COG0569	domain protein
DP_RS03760	COG1238	metal cluster binding
DP_RS03770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DP_RS03770	COG0116	Belongs to the methyltransferase superfamily
DP_RS03775	COG2205	protein histidine kinase activity
DP_RS03775	COG0784	Response regulator, receiver
DP_RS03780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DP_RS03785	COG1151	hydroxylamine reductase activity
DP_RS03800	COG2358	TRAP transporter, solute receptor (TAXI family
DP_RS03805	COG0242	peptide deformylase activity
DP_RS03810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DP_RS03815	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DP_RS03820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DP_RS03830	COG0745	RESPONSE REGULATOR receiver
DP_RS03850	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DP_RS03855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DP_RS03860	COG1122	ATPase activity
DP_RS03865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DP_RS03875	COG0310	cobalt ion transport
DP_RS03880	COG0310	cobalt ion transport
DP_RS03885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DP_RS03885	COG1017	nitric oxide dioxygenase activity
DP_RS03890	COG1720	tRNA m6t6A37 methyltransferase activity
DP_RS03900	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DP_RS03905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DP_RS03910	COG0504	CTP synthase activity
DP_RS03915	COG0471	metal ion transport
DP_RS03920	COG0471	metal ion transport
DP_RS03930	COG4656	Part of a membrane complex involved in electron transport
DP_RS03935	COG4658	electron transport chain
DP_RS03945	COG4660	Part of a membrane complex involved in electron transport
DP_RS03955	COG2878	Part of a membrane complex involved in electron transport
DP_RS03955	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
DP_RS03960	COG1477	protein flavinylation
DP_RS03970	COG0538	isocitrate dehydrogenase activity
DP_RS03975	COG2848	UPF0210 protein
DP_RS03980	COG3830	Belongs to the UPF0237 family
DP_RS03990	COG0012	GTP binding
DP_RS03995	COG3481	metal-dependent phosphohydrolase, HD sub domain
DP_RS04005	COG1774	PSP1 C-terminal conserved region
DP_RS04010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DP_RS04010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DP_RS04030	COG0149	triose-phosphate isomerase activity
DP_RS04045	COG0358	DNA primase activity
DP_RS04055	COG0758	DNA mediated transformation
DP_RS04060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DP_RS04065	COG0166	Belongs to the GPI family
DP_RS04070	COG2221	Nitrite and sulphite reductase 4Fe-4S
DP_RS04075	COG2221	Nitrite and sulphite reductase 4Fe-4S
DP_RS04090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DP_RS04095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DP_RS04095	COG0517	IMP dehydrogenase activity
DP_RS04115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DP_RS04120	COG1691	(AIR) carboxylase
DP_RS04125	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DP_RS04135	COG3118	belongs to the thioredoxin family
DP_RS04140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DP_RS04155	COG0356	it plays a direct role in the translocation of protons across the membrane
DP_RS04160	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DP_RS04165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DP_RS04170	COG0776	regulation of translation
DP_RS04190	COG0574	Belongs to the PEP-utilizing enzyme family
DP_RS04190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DP_RS04205	COG0733	neurotransmitter:sodium symporter activity
DP_RS04210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DP_RS04220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DP_RS04225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DP_RS04230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DP_RS04235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DP_RS04240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DP_RS04245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DP_RS04250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DP_RS04275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DP_RS04285	COG1032	radical SAM domain protein
DP_RS04290	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DP_RS04295	COG0659	secondary active sulfate transmembrane transporter activity
DP_RS04305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DP_RS04310	COG0445	tRNA wobble uridine modification
DP_RS04315	COG2890	protein-(glutamine-N5) methyltransferase activity
DP_RS04320	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DP_RS04325	COG0594	ribonuclease P activity
DP_RS04330	COG0706	membrane insertase activity
DP_RS04340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DP_RS04345	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DP_RS04370	COG0840	transmembrane signaling receptor activity
DP_RS04400	COG0028	Belongs to the TPP enzyme family
DP_RS04405	COG0348	domain, Protein
DP_RS04415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DP_RS04420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DP_RS04425	COG0512	Glutamine amidotransferase of anthranilate synthase
DP_RS04445	COG0210	DNA helicase
DP_RS04450	COG2205	protein histidine kinase activity
DP_RS04450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DP_RS04460	COG0537	adenosine 5'-monophosphoramidase activity
DP_RS04470	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DP_RS04480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DP_RS04485	COG1971	Probably functions as a manganese efflux pump
DP_RS04495	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DP_RS04495	COG0674	pyruvate-flavodoxin oxidoreductase activity
DP_RS04520	COG0513	Belongs to the DEAD box helicase family
DP_RS04525	COG0539	negative regulation of cytoplasmic translation
DP_RS04530	COG0776	regulation of translation
DP_RS04535	COG0009	L-threonylcarbamoyladenylate synthase
DP_RS04540	COG0517	IMP dehydrogenase activity
DP_RS04540	COG0516	GMP reductase activity
DP_RS04545	COG0519	Catalyzes the synthesis of GMP from XMP
DP_RS04545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DP_RS04555	COG0668	transmembrane transport
DP_RS04575	COG0328	RNA-DNA hybrid ribonuclease activity
DP_RS04590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DP_RS04610	COG0351	phosphomethylpyrimidine kinase
DP_RS04625	COG0531	amino acid
DP_RS04630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DP_RS04640	COG1575	Belongs to the MenA family. Type 1 subfamily
DP_RS04645	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DP_RS04655	COG1294	oxidase, subunit
DP_RS04660	COG1271	oxidase subunit
DP_RS04710	COG4895	conserved protein (DUF2196)
DP_RS04720	COG0513	Belongs to the DEAD box helicase family
DP_RS04725	COG0288	reversible hydration of carbon dioxide
DP_RS04780	COG1454	alcohol dehydrogenase
DP_RS04785	COG1454	alcohol dehydrogenase
DP_RS04790	COG2204	response regulator
DP_RS04795	COG4191	Histidine kinase
DP_RS04800	COG1454	alcohol dehydrogenase
DP_RS04805	COG0814	amino acid
DP_RS04835	COG1278	Cold shock
DP_RS04855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DP_RS04870	COG0659	secondary active sulfate transmembrane transporter activity
DP_RS04880	COG0709	Synthesizes selenophosphate from selenide and ATP
DP_RS04895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DP_RS04900	COG0569	domain protein
DP_RS04910	COG0569	domain protein
DP_RS04910	COG2985	domain, Protein
DP_RS04915	COG0840	transmembrane signaling receptor activity
DP_RS04940	COG2326	polyphosphate kinase activity
DP_RS04945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DP_RS04975	COG0765	amino acid transport
DP_RS05000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DP_RS05005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DP_RS05010	COG2920	part of a sulfur-relay system
DP_RS05025	COG0488	(ABC) transporter
DP_RS05035	COG2815	serine threonine protein kinase
DP_RS05035	COG0515	serine threonine protein kinase
DP_RS05040	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DP_RS05055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DP_RS05065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DP_RS05080	COG0247	lactate metabolic process
DP_RS05100	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DP_RS05105	COG3259	Nickel-dependent hydrogenase
DP_RS05130	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DP_RS05135	COG1139	Iron-sulfur cluster binding protein
DP_RS05140	COG1556	Lactate utilization protein
DP_RS05150	COG0277	FAD linked oxidase domain protein
DP_RS05155	COG1620	l-lactate permease
DP_RS05160	COG2204	response regulator
DP_RS05175	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DP_RS05180	COG0765	amino acid transport
DP_RS05185	COG1126	abc transporter atp-binding protein
DP_RS05200	COG1280	lysine exporter protein (LysE YggA)
DP_RS05205	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DP_RS05215	COG1454	alcohol dehydrogenase
DP_RS05220	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DP_RS05240	COG2204	response regulator
DP_RS05245	COG2205	protein histidine kinase activity
DP_RS05250	COG3260	NADH ubiquinone oxidoreductase 20
DP_RS05255	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DP_RS05255	COG0649	NAD binding
DP_RS05260	COG0651	ATP synthesis coupled electron transport
DP_RS05270	COG0650	Formate hydrogenlyase subunit 4
DP_RS05275	COG0651	ATP synthesis coupled electron transport
DP_RS05330	COG0837	glucose binding
DP_RS05360	COG3108	Peptidase M15
DP_RS05365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DP_RS05435	COG0768	penicillin binding
DP_RS05440	COG0772	Belongs to the SEDS family
DP_RS05445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DP_RS05455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DP_RS05455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DP_RS05465	COG0352	thiamine-phosphate diphosphorylase activity
DP_RS05475	COG0330	HflC and HflK could
DP_RS05485	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DP_RS05495	COG0196	riboflavin kinase activity
DP_RS05520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DP_RS05520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DP_RS05525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DP_RS05530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DP_RS05550	COG1233	COG1233 Phytoene dehydrogenase and related
DP_RS05585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DP_RS05610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DP_RS05615	COG0081	regulation of translation
DP_RS05620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DP_RS05625	COG0222	ribosome binding
DP_RS05630	COG0085	RNA polymerase activity
DP_RS05635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DP_RS05640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DP_RS05645	COG0049	tRNA binding
DP_RS05650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DP_RS05655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DP_RS05660	COG0051	transcription antitermination factor activity, RNA binding
DP_RS05665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DP_RS05670	COG0088	Forms part of the polypeptide exit tunnel
DP_RS05675	COG0089	rRNA binding
DP_RS05680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DP_RS05685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DP_RS05690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DP_RS05695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DP_RS05700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DP_RS05705	COG0255	Belongs to the universal ribosomal protein uL29 family
DP_RS05710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DP_RS05715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DP_RS05720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DP_RS05725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DP_RS05730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DP_RS05745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DP_RS05750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DP_RS05755	COG1841	ribosomal large subunit assembly
DP_RS05760	COG0200	Binds to the 23S rRNA
DP_RS05775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DP_RS05780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DP_RS05785	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DP_RS05790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DP_RS05795	COG0202	RNA polymerase activity
DP_RS05800	COG0203	ribosomal protein L17
DP_RS05805	COG0052	Belongs to the universal ribosomal protein uS2 family
DP_RS05810	COG0052	Belongs to the universal ribosomal protein uS2 family
DP_RS05815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DP_RS05820	COG0528	UMP kinase activity
DP_RS05825	COG0233	cytoplasmic translational termination
DP_RS05835	COG4589	Belongs to the CDS family
DP_RS05840	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DP_RS05845	COG0750	zinc metalloprotease
DP_RS05850	COG1214	PFAM Peptidase M22, glycoprotease
DP_RS05855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DP_RS05860	COG0442	prolyl-tRNA aminoacylation
DP_RS05885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DP_RS05925	COG3177	Filamentation induced by cAMP protein fic
DP_RS05940	COG4608	Belongs to the ABC transporter superfamily
DP_RS05945	COG0444	Belongs to the ABC transporter superfamily
DP_RS05950	COG0601	transmembrane transport
DP_RS06000	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DP_RS06045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DP_RS06055	COG0674	pyruvate-flavodoxin oxidoreductase activity
DP_RS06060	COG1013	pyruvate-flavodoxin oxidoreductase activity
DP_RS06065	COG0318	PFAM AMP-dependent synthetase and ligase
DP_RS06080	COG0601	transmembrane transport
DP_RS06085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DP_RS06090	COG4172	Belongs to the ABC transporter superfamily
DP_RS06175	COG1151	hydroxylamine reductase activity
DP_RS06185	COG1151	hydroxylamine reductase activity
DP_RS06190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DP_RS06190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DP_RS06210	COG0573	inorganic phosphate transmembrane transporter activity
DP_RS06220	COG0189	ligase activity
DP_RS06220	COG2918	glutathione biosynthetic process
DP_RS06225	COG0628	permease
DP_RS06235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DP_RS06255	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DP_RS06255	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DP_RS06270	COG2813	Specifically methylates the guanine in position
DP_RS06270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DP_RS06275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DP_RS06290	COG0571	ribonuclease III activity
DP_RS06300	COG0488	(ABC) transporter
DP_RS06320	COG1192	Involved in chromosome partitioning
DP_RS06345	COG1090	epimerase
DP_RS06360	COG1522	sequence-specific DNA binding
DP_RS06370	COG1773	rubredoxin
DP_RS06370	COG1592	Rubrerythrin
DP_RS06375	COG1280	lysine exporter protein (LysE YggA)
DP_RS06380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DP_RS06385	COG0617	tRNA 3'-terminal CCA addition
DP_RS06385	COG0517	IMP dehydrogenase activity
DP_RS06385	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DP_RS06400	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DP_RS06435	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DP_RS06440	COG1115	amino acid carrier protein
DP_RS06445	COG1115	amino acid carrier protein
DP_RS06450	COG0840	transmembrane signaling receptor activity
DP_RS06455	COG1966	Carbon starvation protein
DP_RS06465	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DP_RS06470	COG0535	radical SAM domain protein
DP_RS06475	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DP_RS06480	COG0357	Ribosomal RNA small subunit methyltransferase G
DP_RS06485	COG0473	3-isopropylmalate dehydrogenase activity
DP_RS06495	COG1115	amino acid carrier protein
DP_RS06500	COG1741	Belongs to the pirin family
DP_RS06510	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
DP_RS06515	COG4681	YaeQ
DP_RS06555	COG1115	amino acid carrier protein
DP_RS06585	COG1671	Belongs to the UPF0178 family
DP_RS06630	COG0501	Belongs to the peptidase M48B family
DP_RS06635	COG1007	ATP synthesis coupled electron transport
DP_RS06645	COG0651	ATP synthesis coupled electron transport
DP_RS06655	COG0651	ATP synthesis coupled electron transport
DP_RS06660	COG0713	ATP synthesis coupled electron transport
DP_RS06675	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DP_RS06680	COG0649	NAD binding
DP_RS06685	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DP_RS06690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DP_RS06695	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DP_RS06705	COG0583	DNA-binding transcription factor activity
DP_RS06710	COG0101	tRNA pseudouridine synthase activity
DP_RS06715	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DP_RS06720	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DP_RS06725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DP_RS06735	COG0131	Imidazoleglycerol-phosphate dehydratase
DP_RS06745	COG0037	tRNA processing
DP_RS06750	COG0017	Asparaginyl-tRNA synthetase
DP_RS06755	COG2226	methyltransferase
DP_RS06760	COG1022	Amp-dependent synthetase and ligase
DP_RS06795	COG0589	response to stress
DP_RS06815	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DP_RS06820	COG1074	ATP-dependent DNA helicase activity
DP_RS06825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DP_RS06865	COG3842	ATPase activity
DP_RS06935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DP_RS06945	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DP_RS06960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DP_RS06960	COG0574	Belongs to the PEP-utilizing enzyme family
DP_RS06965	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DP_RS06970	COG1984	allophanate hydrolase subunit 2
DP_RS06975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DP_RS06980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DP_RS06985	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DP_RS06990	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DP_RS07005	COG0697	spore germination
DP_RS07020	COG1979	alcohol dehydrogenase
DP_RS07035	COG1162	GTPase activity
DP_RS07040	COG0251	oxidation-reduction process
DP_RS07045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DP_RS07050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DP_RS07065	COG3829	transcription factor binding
DP_RS07080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DP_RS07090	COG3842	ATPase activity
DP_RS07105	COG1114	Component of the transport system for branched-chain amino acids
DP_RS07165	COG2770	Histidine kinase
DP_RS07165	COG2208	phosphoserine phosphatase activity
DP_RS07190	COG0513	Belongs to the DEAD box helicase family
DP_RS07240	COG0776	regulation of translation
DP_RS07245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DP_RS07245	COG0072	phenylalanine-tRNA ligase activity
DP_RS07250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DP_RS07255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DP_RS07260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DP_RS07265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DP_RS07270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DP_RS07280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DP_RS07285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DP_RS07290	COG0686	Belongs to the AlaDH PNT family
DP_RS07300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DP_RS07310	COG0765	amino acid transport
DP_RS07315	COG1126	abc transporter atp-binding protein
DP_RS07340	COG3273	potassium ion transport
DP_RS07340	COG0471	metal ion transport
DP_RS07345	COG1164	Oligoendopeptidase f
DP_RS07350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DP_RS07370	COG0436	Aminotransferase
DP_RS07390	COG4969	Belongs to the N-Me-Phe pilin family
DP_RS07455	COG4969	Belongs to the N-Me-Phe pilin family
DP_RS07475	COG2046	Belongs to the sulfate adenylyltransferase family
DP_RS07495	COG0590	tRNA wobble adenosine to inosine editing
DP_RS07505	COG0805	protein transport
DP_RS07510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DP_RS07515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DP_RS07520	COG1758	RNA polymerase activity
DP_RS07525	COG0484	heat shock protein binding
DP_RS07530	COG0315	cyclic pyranopterin monophosphate synthase activity
DP_RS07535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DP_RS07540	COG1469	GTP cyclohydrolase I activity
DP_RS07545	COG0751	glycine-tRNA ligase activity
DP_RS07570	COG2204	response regulator
DP_RS07575	COG2204	response regulator
DP_RS07590	COG2252	PERMEase
DP_RS07600	COG1846	Transcriptional regulator
DP_RS07610	COG2223	nitrite transmembrane transporter activity
DP_RS07625	COG0251	oxidation-reduction process
DP_RS07630	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DP_RS07635	COG1301	dicarboxylic acid transport
DP_RS07645	COG0251	oxidation-reduction process
DP_RS07650	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DP_RS07655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DP_RS07660	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DP_RS07665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DP_RS07665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DP_RS07685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DP_RS07705	COG2831	hemolysin activation secretion protein
DP_RS07710	COG2831	hemolysin activation secretion protein
DP_RS07775	COG4964	Belongs to the GSP D family
DP_RS07805	COG0842	Transport permease protein
DP_RS07810	COG0842	Transport permease protein
DP_RS07815	COG1131	(ABC) transporter
DP_RS07845	COG0446	pyridine nucleotide-disulphide oxidoreductase
DP_RS07865	COG2201	protein-glutamate methylesterase activity
DP_RS07890	COG0765	amino acid transport
DP_RS08130	COG4974	Belongs to the 'phage' integrase family
DP_RS08140	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DP_RS08145	COG1702	phosphate starvation-inducible protein PhoH
DP_RS08170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DP_RS08175	COG1469	GTP cyclohydrolase I activity
DP_RS08180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DP_RS08185	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DP_RS08190	COG0138	bifunctional purine biosynthesis protein purh
DP_RS08195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DP_RS08200	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DP_RS08210	COG0268	Binds directly to 16S ribosomal RNA
DP_RS08220	COG0512	Glutamine amidotransferase of anthranilate synthase
DP_RS08225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DP_RS08230	COG0134	indole-3-glycerol-phosphate synthase activity
DP_RS08235	COG0135	phosphoribosylanthranilate isomerase activity
DP_RS08260	COG1136	(ABC) transporter
DP_RS08265	COG4591	ABC-type transport system involved in lipoprotein release permease component
DP_RS08270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DP_RS08275	COG0159	tryptophan synthase activity
DP_RS08285	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DP_RS08295	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DP_RS08300	COG0726	polysaccharide deacetylase
DP_RS08300	COG1649	PFAM Uncharacterised BCR, COG1649
DP_RS08315	COG1215	transferase activity, transferring glycosyl groups
DP_RS08325	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DP_RS08335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DP_RS08345	COG0443	Heat shock 70 kDa protein
DP_RS08355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DP_RS08360	COG0426	domain, Protein
DP_RS08380	COG0398	Pfam SNARE associated Golgi protein
DP_RS08405	COG1773	rubredoxin
DP_RS08405	COG1592	Rubrerythrin
DP_RS08415	COG1516	flagellar protein fliS
DP_RS08420	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DP_RS08440	COG0587	DNA-directed DNA polymerase activity
DP_RS08450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DP_RS08455	COG1494	fructose-1,6-bisphosphatase
DP_RS08460	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DP_RS08470	COG2033	superoxide reductase activity
DP_RS08480	COG1528	Iron-storage protein
DP_RS08490	COG0501	Belongs to the peptidase M48B family
DP_RS08495	COG0670	Belongs to the BI1 family
DP_RS08500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DP_RS08510	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DP_RS08520	COG0741	lytic transglycosylase activity
DP_RS08520	COG1388	LysM domain
DP_RS08530	COG1534	Rna-binding protein
DP_RS08540	COG0791	NLP P60 protein
DP_RS08545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DP_RS08550	COG1333	cytochrome c biogenesis protein
DP_RS08555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DP_RS08565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DP_RS08580	COG0557	exoribonuclease II activity
DP_RS08585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DP_RS08595	COG0513	Belongs to the DEAD box helicase family
DP_RS08600	COG1921	L-seryl-tRNASec selenium transferase activity
DP_RS08610	COG1611	Belongs to the LOG family
DP_RS08630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DP_RS08635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DP_RS08645	COG2873	o-acetylhomoserine
DP_RS08655	COG1757	Na H antiporter
DP_RS08660	COG0484	heat shock protein binding
DP_RS08665	COG2333	competence protein COMEC
DP_RS08665	COG0658	competence protein
DP_RS08670	COG1519	Transferase
DP_RS08675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DP_RS08685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DP_RS08690	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DP_RS08695	COG0424	maF-like protein
DP_RS08720	COG2963	transposase activity
DP_RS08770	COG0746	molybdenum cofactor guanylyltransferase activity
DP_RS08780	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DP_RS08780	COG2080	2 iron, 2 sulfur cluster binding
DP_RS08815	COG0824	Thioesterase
DP_RS08820	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DP_RS08830	COG0563	adenylate kinase activity
DP_RS08840	COG0318	PFAM AMP-dependent synthetase and ligase
DP_RS08855	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DP_RS08865	COG2022	thiamine diphosphate biosynthetic process
DP_RS08870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DP_RS08875	COG0138	bifunctional purine biosynthesis protein purh
DP_RS08880	COG0142	geranyltranstransferase activity
DP_RS08885	COG1199	ATP-dependent helicase activity
DP_RS08895	COG1943	Transposase
DP_RS08930	COG1136	(ABC) transporter
DP_RS08930	COG0577	efflux transmembrane transporter activity
DP_RS08935	COG1136	(ABC) transporter
DP_RS08985	COG0805	protein transport
DP_RS08990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DP_RS09010	COG0437	4 iron, 4 sulfur cluster binding
DP_RS09015	COG3383	formate dehydrogenase (NAD+) activity
DP_RS09045	COG4585	Histidine kinase
DP_RS09055	COG4651	solute:proton antiporter activity
DP_RS09055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DP_RS09060	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DP_RS09065	COG0798	PFAM Bile acid sodium symporter
DP_RS09125	COG3706	GGDEF domain
DP_RS09125	COG5001	Diguanylate cyclase
DP_RS09125	COG2203	Gaf domain
DP_RS09125	COG4251	negative regulation of phosphorylation
DP_RS09135	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DP_RS09140	COG2205	protein histidine kinase activity
DP_RS09140	COG3437	response regulator, receiver
DP_RS09140	COG3850	Histidine kinase
DP_RS09140	COG4999	Histidine kinase
DP_RS09160	COG0525	valine-tRNA ligase activity
DP_RS09165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DP_RS09170	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DP_RS09175	COG0148	phosphopyruvate hydratase activity
DP_RS09195	COG1805	sodium ion transport
DP_RS09205	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DP_RS09210	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DP_RS09215	COG2871	sodium ion transport
DP_RS09225	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DP_RS09230	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DP_RS09240	COG0439	Biotin carboxylase
DP_RS09245	COG0825	malonyl-CoA metabolic process
DP_RS09255	COG2951	lytic endotransglycosylase activity
DP_RS09260	COG1032	radical SAM domain protein
DP_RS09280	COG4978	Transcriptional regulator
DP_RS09280	COG0789	Transcriptional regulator
DP_RS09295	COG1012	belongs to the aldehyde dehydrogenase family
DP_RS09295	COG1454	alcohol dehydrogenase
DP_RS09300	COG1882	Formate acetyltransferase
DP_RS09305	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DP_RS09365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DP_RS09375	COG1131	(ABC) transporter
DP_RS09390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DP_RS09425	COG1028	Short-chain dehydrogenase reductase Sdr
DP_RS09435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DP_RS09465	COG0535	radical SAM domain protein
DP_RS09480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DP_RS09490	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DP_RS09505	COG2814	Major facilitator Superfamily
DP_RS09530	COG2207	Transcriptional regulator
DP_RS09535	COG1979	alcohol dehydrogenase
DP_RS09540	COG0330	HflC and HflK could
DP_RS09550	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DP_RS09550	COG3608	succinylglutamate desuccinylase aspartoacylase
DP_RS09565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DP_RS09570	COG1272	protein, Hemolysin III
DP_RS09575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DP_RS09585	COG3228	Belongs to the MtfA family
DP_RS09590	COG0251	oxidation-reduction process
DP_RS09595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DP_RS09600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DP_RS09610	COG0581	inorganic phosphate transmembrane transporter activity
DP_RS09615	COG0573	inorganic phosphate transmembrane transporter activity
DP_RS09620	COG0704	Plays a role in the regulation of phosphate uptake
DP_RS09625	COG0745	RESPONSE REGULATOR receiver
DP_RS09630	COG5002	protein histidine kinase activity
DP_RS09635	COG2824	Alkylphosphonate utilization operon protein PhnA
DP_RS09650	COG1132	(ABC) transporter
DP_RS09665	COG1366	Belongs to the anti-sigma-factor antagonist family
DP_RS09695	COG0840	transmembrane signaling receptor activity
DP_RS09705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DP_RS09715	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DP_RS09725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DP_RS09730	COG0557	exoribonuclease II activity
DP_RS09745	COG0205	6-phosphofructokinase activity
DP_RS09755	COG0542	response to heat
DP_RS09785	COG2249	NAD(P)H dehydrogenase (quinone) activity
DP_RS09800	COG1012	belongs to the aldehyde dehydrogenase family
DP_RS09820	COG1794	racemase activity, acting on amino acids and derivatives
DP_RS09860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DP_RS09870	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DP_RS09875	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DP_RS09875	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DP_RS09880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DP_RS09895	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DP_RS09905	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DP_RS09910	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DP_RS09915	COG0673	inositol 2-dehydrogenase activity
DP_RS09920	COG1663	tetraacyldisaccharide 4'-kinase activity
DP_RS09925	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DP_RS09935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DP_RS09940	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DP_RS09945	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DP_RS09970	COG0105	UTP biosynthetic process
DP_RS09975	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DP_RS09990	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DP_RS10010	COG0802	atpase or kinase
DP_RS10020	COG0066	3-isopropylmalate dehydratase activity
DP_RS10025	COG2204	response regulator
DP_RS10055	COG0484	heat shock protein binding
DP_RS10070	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DP_RS10085	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DP_RS10090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DP_RS10095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DP_RS10100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DP_RS10105	COG0513	Belongs to the DEAD box helicase family
DP_RS10135	COG5001	Diguanylate cyclase
DP_RS10135	COG4251	negative regulation of phosphorylation
DP_RS10135	COG2203	Gaf domain
DP_RS10135	COG3706	GGDEF domain
DP_RS10140	COG0840	transmembrane signaling receptor activity
DP_RS10150	COG0765	amino acid transport
DP_RS10170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DP_RS10185	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DP_RS10350	COG3437	response regulator, receiver
DP_RS10350	COG2770	Histidine kinase
DP_RS10415	COG1403	HNH endonuclease
DP_RS10540	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DP_RS10590	COG1278	Cold shock
DP_RS10605	COG0784	Response regulator, receiver
DP_RS10605	COG3437	response regulator, receiver
DP_RS10655	COG1620	l-lactate permease
DP_RS10665	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DP_RS10675	COG1643	Atp-dependent helicase
DP_RS10685	COG0583	DNA-binding transcription factor activity
DP_RS10700	COG0095	Lipoate-protein ligase
DP_RS10710	COG0508	dehydrogenase complex catalyzes the overall conversion of
DP_RS10715	COG0508	dehydrogenase complex catalyzes the overall conversion of
DP_RS10715	COG0022	dehydrogenase e1 component
DP_RS10720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DP_RS10725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DP_RS10740	COG1013	pyruvate-flavodoxin oxidoreductase activity
DP_RS10760	COG0457	Tetratricopeptide repeat
DP_RS10775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DP_RS10780	COG2046	Belongs to the sulfate adenylyltransferase family
DP_RS10795	COG3437	response regulator, receiver
DP_RS10795	COG0784	Response regulator, receiver
DP_RS10820	COG2897	thiosulfate sulfurtransferase activity
DP_RS10845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DP_RS10855	COG1309	transcriptional regulator
DP_RS10875	COG1846	Transcriptional regulator
DP_RS10905	COG4399	Belongs to the UPF0754 family
DP_RS10910	COG0546	phosphoglycolate phosphatase activity
DP_RS10920	COG1053	succinate dehydrogenase
DP_RS10960	COG4221	oxidoreductase activity
DP_RS10975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DP_RS10995	COG3040	lipid binding
DP_RS11020	COG2207	Transcriptional regulator
DP_RS11025	COG1509	lysine 2,3-aminomutase activity
DP_RS11055	COG0308	aminopeptidase N
DP_RS11065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DP_RS11085	COG0037	tRNA processing
DP_RS11090	COG1605	Chorismate mutase
DP_RS11090	COG0077	Prephenate dehydratase
DP_RS11095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DP_RS11100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DP_RS11110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DP_RS11135	COG1227	inorganic diphosphatase activity
DP_RS11150	COG1362	aminopeptidase activity
DP_RS11160	COG0488	(ABC) transporter
DP_RS11165	COG1760	l-serine dehydratase
DP_RS11170	COG0009	L-threonylcarbamoyladenylate synthase
DP_RS11175	COG0151	Belongs to the GarS family
DP_RS11180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DP_RS11195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DP_RS11200	COG0481	GTPase activity
DP_RS11215	COG0697	spore germination
DP_RS11225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DP_RS11230	COG0616	signal peptide processing
DP_RS11235	COG1278	Cold shock
DP_RS11240	COG0646	methionine synthase
DP_RS11240	COG1410	methionine synthase
DP_RS11245	COG0646	methionine synthase
DP_RS11245	COG1410	methionine synthase
DP_RS11250	COG0281	malic enzyme
DP_RS11265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DP_RS11270	COG1643	Atp-dependent helicase
DP_RS11290	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
DP_RS11295	COG3259	Nickel-dependent hydrogenase
DP_RS11300	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DP_RS11310	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DP_RS11315	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DP_RS11325	COG1678	Uncharacterized ACR, COG1678
DP_RS11330	COG0463	Glycosyl transferase, family 2
DP_RS11355	COG0438	transferase activity, transferring glycosyl groups
DP_RS11365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DP_RS11370	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DP_RS11390	COG0033	Phosphoglucomutase
DP_RS11395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DP_RS11400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DP_RS11405	COG2204	response regulator
DP_RS11410	COG0613	PHP domain protein
DP_RS11440	COG0251	oxidation-reduction process
DP_RS11485	COG1720	tRNA m6t6A37 methyltransferase activity
DP_RS11520	COG1914	H( )-stimulated, divalent metal cation uptake system
DP_RS11545	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DP_RS11550	COG0606	chelatase, subunit chli
DP_RS11560	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DP_RS11600	COG1619	proteins homologs of microcin C7 resistance protein MccF
DP_RS11605	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DP_RS11625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DP_RS11630	COG2314	TM2 domain
DP_RS11635	COG2853	Lipoprotein
DP_RS11655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DP_RS11670	COG3437	response regulator, receiver
DP_RS11685	COG1280	lysine exporter protein (LysE YggA)
DP_RS11760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DP_RS11760	COG0515	serine threonine protein kinase
DP_RS11770	COG1309	transcriptional regulator
DP_RS11785	COG1013	pyruvate-flavodoxin oxidoreductase activity
DP_RS11790	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DP_RS11790	COG0674	pyruvate-flavodoxin oxidoreductase activity
DP_RS11800	COG2807	transmembrane transport
DP_RS11805	COG2186	Transcriptional regulator
DP_RS11815	COG0189	ligase activity
DP_RS11830	COG3961	Belongs to the TPP enzyme family
DP_RS11835	COG1012	belongs to the aldehyde dehydrogenase family
DP_RS11845	COG0277	FAD linked oxidase domain protein
DP_RS11845	COG0247	lactate metabolic process
DP_RS11905	COG1802	Transcriptional regulator
DP_RS11925	COG1228	amidohydrolase
DP_RS11930	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DP_RS11935	COG2986	histidine ammonia-lyase
DP_RS11950	COG0101	tRNA pseudouridine synthase activity
DP_RS11970	COG0835	chemotaxis
DP_RS12005	COG2226	methyltransferase
DP_RS12060	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DP_RS12070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DP_RS12085	COG0464	growth
DP_RS12100	COG1968	undecaprenyl-diphosphatase activity
DP_RS12110	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DP_RS12115	COG0114	fumarate hydratase activity
DP_RS12145	COG0189	ligase activity
DP_RS12145	COG4067	protein conserved in archaea
DP_RS12155	COG2731	YhcH YjgK YiaL family protein
DP_RS12160	COG0521	Mo-molybdopterin cofactor biosynthetic process
DP_RS12165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DP_RS12170	COG0728	peptidoglycan biosynthetic process
DP_RS12180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DP_RS12195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DP_RS12200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DP_RS12220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DP_RS12225	COG0811	peptide transport
DP_RS12240	COG0823	Involved in the tonB-independent uptake of proteins
DP_RS12260	COG0708	Exodeoxyribonuclease III
DP_RS12265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DP_RS12300	COG0768	penicillin binding
DP_RS12310	COG0772	Belongs to the SEDS family
DP_RS12390	COG2723	6-phospho-beta-galactosidase activity
DP_RS12405	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
DP_RS12470	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DP_RS12475	COG1454	alcohol dehydrogenase
DP_RS12525	COG0303	'Molybdopterin
DP_RS12530	COG0303	'Molybdopterin
DP_RS12545	COG0322	excinuclease ABC activity
DP_RS12570	COG2257	FlhB HrpN YscU SpaS Family
DP_RS12605	COG1012	belongs to the aldehyde dehydrogenase family
DP_RS12610	COG0506	proline dehydrogenase activity
DP_RS12625	COG1028	Short-chain dehydrogenase reductase Sdr
DP_RS12645	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DP_RS12650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DP_RS12660	COG1090	epimerase
DP_RS12665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DP_RS12690	COG2873	o-acetylhomoserine
DP_RS12695	COG3344	reverse transcriptase
DP_RS12730	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DP_RS12740	COG0840	transmembrane signaling receptor activity
DP_RS12750	COG1584	GPR1 FUN34 yaaH family protein
DP_RS12755	COG2203	Gaf domain
DP_RS12755	COG4251	negative regulation of phosphorylation
DP_RS12755	COG5001	Diguanylate cyclase
DP_RS12755	COG3706	GGDEF domain
DP_RS12760	COG0494	nUDIX hydrolase
DP_RS12780	COG0488	(ABC) transporter
DP_RS12790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DP_RS12795	COG0438	transferase activity, transferring glycosyl groups
DP_RS12805	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DP_RS12810	COG3012	SEC-C Motif Domain Protein
DP_RS12815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DP_RS12830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DP_RS12895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DP_RS12900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DP_RS12905	COG0740	serine-type endopeptidase activity
DP_RS12910	COG0544	peptidyl-prolyl cis-trans isomerase activity
DP_RS12915	COG2239	Acts as a magnesium transporter
DP_RS12940	COG2226	methyltransferase
DP_RS12950	COG0156	8-amino-7-oxononanoate synthase activity
DP_RS12955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DP_RS12955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DP_RS12960	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DP_RS12965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DP_RS12970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DP_RS12975	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DP_RS12980	COG2884	Cell division ATP-binding protein ftsE
DP_RS12985	COG2177	Part of the ABC transporter FtsEX involved in
DP_RS12995	COG0793	Belongs to the peptidase S41A family
DP_RS13085	COG0702	epimerase
DP_RS13090	COG0629	single-stranded DNA binding
DP_RS13095	COG0463	Glycosyl transferase, family 2
DP_RS13095	COG1216	Glycosyl transferase, family 2
DP_RS13100	COG1530	ribonuclease E activity
DP_RS13120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DP_RS13120	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DP_RS13125	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DP_RS13130	COG2201	protein-glutamate methylesterase activity
DP_RS13140	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DP_RS13145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DP_RS13150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DP_RS13155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DP_RS13160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DP_RS13170	COG3956	TIGRFAM MazG family protein
DP_RS13175	COG0360	Binds together with S18 to 16S ribosomal RNA
DP_RS13180	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DP_RS13190	COG0359	binds to the 23S rRNA
DP_RS13195	COG0305	Participates in initiation and elongation during chromosome replication
DP_RS13200	COG0495	leucyl-tRNA aminoacylation
DP_RS13210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DP_RS13220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DP_RS13225	COG1253	flavin adenine dinucleotide binding
DP_RS13230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DP_RS13235	COG0756	dUTP diphosphatase activity
DP_RS13240	COG1185	polyribonucleotide nucleotidyltransferase activity
DP_RS13245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DP_RS13250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DP_RS13260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DP_RS13265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DP_RS13265	COG3064	Membrane
DP_RS13280	COG0779	Required for maturation of 30S ribosomal subunits
DP_RS13300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DP_RS13305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DP_RS13320	COG0492	ferredoxin-NADP+ reductase activity
DP_RS13335	COG1392	Phosphate transport regulator
DP_RS13340	COG0306	phosphate transporter
DP_RS13345	COG4783	chaperone-mediated protein folding
DP_RS13350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DP_RS13355	COG0318	PFAM AMP-dependent synthetase and ligase
DP_RS13360	COG0596	Alpha beta hydrolase
DP_RS13370	COG1132	(ABC) transporter
DP_RS13375	COG3852	Histidine kinase
DP_RS13385	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DP_RS13390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DP_RS13395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DP_RS13400	COG1047	Peptidyl-prolyl cis-trans
DP_RS13405	COG0643	Histidine kinase
DP_RS13405	COG2198	Histidine kinase
DP_RS13405	COG0784	Response regulator, receiver
DP_RS13415	COG2201	protein-glutamate methylesterase activity
DP_RS13420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DP_RS13450	COG0745	RESPONSE REGULATOR receiver
DP_RS13460	COG1815	bacterial-type flagellum-dependent cell motility
DP_RS13465	COG1558	bacterial-type flagellum-dependent cell motility
DP_RS13470	COG1677	Flagellar hook-basal body complex protein FliE
DP_RS13480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DP_RS13490	COG1157	protein secretion by the type III secretion system
DP_RS13510	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DP_RS13525	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DP_RS13540	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DP_RS13555	COG1338	Plays a role in the flagellum-specific transport system
DP_RS13560	COG1987	bacterial-type flagellum assembly
DP_RS13565	COG1684	flagellar biosynthetic protein fliR
DP_RS13570	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DP_RS13575	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DP_RS13580	COG1419	protein localization to endoplasmic reticulum
DP_RS13590	COG1191	sigma factor activity
DP_RS13600	COG4786	Flagellar basal body rod
DP_RS13605	COG4786	Flagellar basal body rod
DP_RS13615	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DP_RS13620	COG1706	bacterial-type flagellum-dependent cell motility
DP_RS13635	COG2747	anti-sigma28 factor FlgM
DP_RS13650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DP_RS13655	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DP_RS13660	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DP_RS13680	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DP_RS13685	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DP_RS13695	COG1722	exodeoxyribonuclease VII activity
DP_RS13705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DP_RS13720	COG0604	alcohol dehydrogenase
DP_RS13735	COG0840	transmembrane signaling receptor activity
DP_RS13740	COG0778	Nitroreductase
DP_RS13750	COG1733	regulation of RNA biosynthetic process
DP_RS13760	COG1309	transcriptional regulator
DP_RS13780	COG3706	GGDEF domain
DP_RS13795	COG0805	protein transport
DP_RS13800	COG2827	Endonuclease containing a URI domain
DP_RS13810	COG3852	Histidine kinase
DP_RS13820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DP_RS13825	COG2890	protein-(glutamine-N5) methyltransferase activity
DP_RS13830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DP_RS13835	COG0254	rRNA binding
DP_RS13840	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DP_RS13845	COG0237	dephospho-CoA kinase activity
DP_RS13850	COG0564	pseudouridine synthase activity
DP_RS13860	COG0193	aminoacyl-tRNA hydrolase activity
DP_RS13865	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DP_RS13870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DP_RS13885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DP_RS13895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DP_RS13900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DP_RS13915	COG0406	alpha-ribazole phosphatase activity
DP_RS13920	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DP_RS13930	COG2326	polyphosphate kinase activity
DP_RS13935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DP_RS13945	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DP_RS13955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DP_RS13965	COG0653	protein targeting
DP_RS13975	COG0018	arginyl-trna synthetase
DP_RS13980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DP_RS14000	COG0564	pseudouridine synthase activity
DP_RS14015	COG2226	methyltransferase
DP_RS14020	COG1797	cobyrinic acid a,c-diamide synthase activity
DP_RS14030	COG0556	nucleotide-excision repair
DP_RS14035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DP_RS14045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DP_RS14050	COG0028	Belongs to the TPP enzyme family
DP_RS14055	COG0440	acetolactate synthase activity
DP_RS14060	COG0688	phosphatidylethanolamine metabolic process
DP_RS14070	COG0742	ribosomal rna small subunit methyltransferase
DP_RS14075	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DP_RS14085	COG1100	Small GTP-binding protein
DP_RS14095	COG0084	hydrolase, TatD family'
DP_RS14100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DP_RS14110	COG1459	type II secretion system
DP_RS14120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DP_RS14120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DP_RS14125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DP_RS14130	COG0698	ribose 5-phosphate isomerase
DP_RS14135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DP_RS14140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DP_RS14145	COG1028	Short-chain dehydrogenase reductase Sdr
DP_RS14155	COG2086	electron transfer activity
DP_RS14160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DP_RS14175	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DP_RS14185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DP_RS14190	COG0228	four-way junction DNA binding
DP_RS14195	COG1837	Belongs to the UPF0109 family
DP_RS14205	COG0336	Belongs to the RNA methyltransferase TrmD family
DP_RS14210	COG4752	Belongs to the RNA methyltransferase TrmD family
DP_RS14210	COG0336	Belongs to the RNA methyltransferase TrmD family
DP_RS14215	COG0335	large ribosomal subunit rRNA binding
DP_RS14220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DP_RS14225	COG0792	nuclease activity
DP_RS14230	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DP_RS14235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DP_RS14260	COG2027	D-alanyl-D-alanine carboxypeptidase
DP_RS14265	COG0438	transferase activity, transferring glycosyl groups
DP_RS14275	COG1519	Transferase
DP_RS14285	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DP_RS14290	COG1342	Belongs to the UPF0251 family
DP_RS14300	COG5000	phosphorelay sensor kinase activity
DP_RS14305	COG2204	response regulator
DP_RS14310	COG0113	porphobilinogen synthase activity
DP_RS14320	COG0653	protein targeting
DP_RS14340	COG0517	IMP dehydrogenase activity
DP_RS14340	COG0516	GMP reductase activity
DP_RS14385	COG2814	Major facilitator Superfamily
DP_RS14390	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DP_RS14395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DP_RS14410	COG0746	molybdenum cofactor guanylyltransferase activity
DP_RS14415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DP_RS14425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DP_RS14435	COG0539	negative regulation of cytoplasmic translation
DP_RS14440	COG2365	Tyrosine phosphatase family
DP_RS14445	COG2365	Tyrosine phosphatase family
DP_RS14455	COG0826	peptidase U32
DP_RS14465	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DP_RS14475	COG0456	acetyltransferase
DP_RS14485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DP_RS14490	COG0194	GDP metabolic process
DP_RS14495	COG2052	Domain of unknown function (DUF370)
DP_RS14500	COG1561	YicC-like family, N-terminal region
DP_RS14510	COG2885	chlorophyll binding
DP_RS14525	COG0735	belongs to the Fur family
DP_RS14535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DP_RS14540	COG1418	mRNA catabolic process
DP_RS14555	COG1051	belongs to the nudix hydrolase family
DP_RS14570	COG1295	ribonuclease BN
DP_RS14570	COG1959	2 iron, 2 sulfur cluster binding
DP_RS14580	COG0285	dihydrofolate synthase activity
DP_RS14585	COG0210	DNA helicase
DP_RS14595	COG1472	Belongs to the glycosyl hydrolase 3 family
DP_RS14620	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DP_RS14620	COG1013	pyruvate-flavodoxin oxidoreductase activity
DP_RS14620	COG0674	pyruvate-flavodoxin oxidoreductase activity
DP_RS14620	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DP_RS14645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DP_RS14650	COG3852	Histidine kinase
DP_RS14655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DP_RS14660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DP_RS14670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DP_RS14675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DP_RS14680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DP_RS14685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DP_RS14690	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DP_RS14695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DP_RS14700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DP_RS14715	COG0275	rRNA processing
DP_RS14720	COG2001	Belongs to the MraZ family
DP_RS14725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DP_RS14730	COG0217	transcriptional regulatory protein
DP_RS14735	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DP_RS14740	COG0617	tRNA 3'-terminal CCA addition
DP_RS14745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DP_RS14755	COG1773	rubredoxin
DP_RS14765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DP_RS14770	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DP_RS14785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DP_RS14785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DP_RS14790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DP_RS14800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DP_RS14805	COG0741	lytic transglycosylase activity
DP_RS14815	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DP_RS14815	COG0662	Cupin 2, conserved barrel domain protein
DP_RS14820	COG2211	Major facilitator Superfamily
DP_RS14825	COG0215	cysteine-tRNA ligase activity
DP_RS14830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DP_RS14850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DP_RS14855	COG0489	protein tyrosine kinase activity
DP_RS14860	COG0552	protein localization to endoplasmic reticulum
DP_RS14865	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DP_RS14870	COG0436	Aminotransferase
DP_RS14885	COG1213	nucleotidyl transferase
DP_RS14895	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DP_RS14900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DP_RS14905	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DP_RS14910	COG3876	Protein conserved in bacteria
DP_RS14915	COG0626	cystathionine gamma-synthase activity
DP_RS14920	COG0133	tryptophan synthase activity
DP_RS14925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DP_RS14930	COG3706	GGDEF domain
DP_RS14940	COG0826	peptidase U32
DP_RS14945	COG0482	sulfurtransferase activity
DP_RS14950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DP_RS14955	COG1058	Belongs to the CinA family
DP_RS14955	COG1546	Belongs to the CinA family
DP_RS14965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DP_RS14985	COG3264	Mechanosensitive ion channel
DP_RS14985	COG1196	nuclear chromosome segregation
DP_RS14990	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
DP_RS15050	COG0848	biopolymer transport protein
DP_RS15080	COG1120	ATPase activity
DP_RS15085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DP_RS15090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DP_RS15095	COG4771	TonB-dependent receptor
DP_RS15115	COG0243	molybdopterin cofactor binding
DP_RS15125	COG0437	4 iron, 4 sulfur cluster binding
DP_RS15140	COG0303	'Molybdopterin
DP_RS15160	COG4625	pathogenesis
DP_RS15160	COG3240	lipase activity
DP_RS15205	COG0753	catalase activity
DP_RS15210	COG0247	lactate metabolic process
DP_RS15215	COG1139	Iron-sulfur cluster binding protein
DP_RS15235	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DP_RS15240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DP_RS15245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DP_RS15250	COG0710	3-dehydroquinate dehydratase activity
DP_RS15260	COG0167	dihydroorotate dehydrogenase activity
DP_RS15265	COG0543	2 iron, 2 sulfur cluster binding
DP_RS15275	COG1607	acyl-coa hydrolase
DP_RS15290	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DP_RS15305	COG1944	ATP diphosphatase activity
DP_RS15310	COG0564	pseudouridine synthase activity
DP_RS15315	COG0731	radical SAM domain protein
DP_RS15315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DP_RS15320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DP_RS15325	COG1882	Formate acetyltransferase
DP_RS15330	COG1012	belongs to the aldehyde dehydrogenase family
DP_RS15340	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
DP_RS15345	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
DP_RS15355	COG4656	Part of a membrane complex involved in electron transport
DP_RS15385	COG1012	belongs to the aldehyde dehydrogenase family
DP_RS15390	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
DP_RS15395	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
DP_RS15410	COG4656	Part of a membrane complex involved in electron transport
DP_RS15440	COG2086	electron transfer activity
DP_RS15445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DP_RS15450	COG0247	lactate metabolic process
DP_RS15450	COG2181	nitrate reductase activity
DP_RS15455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DP_RS15455	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DP_RS15460	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DP_RS15465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DP_RS15480	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DP_RS15485	COG0038	chloride channel
DP_RS15495	COG1121	(ABC) transporter
DP_RS15500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DP_RS15505	COG2068	MobA-Related Protein
DP_RS15510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DP_RS15575	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DP_RS15580	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DP_RS15585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DP_RS15585	COG1648	precorrin-2 dehydrogenase activity
DP_RS15630	COG2226	methyltransferase
DP_RS15635	COG0500	methyltransferase
DP_RS15640	COG2226	methyltransferase
DP_RS15655	COG0505	Belongs to the CarA family
DP_RS15660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DP_RS15665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DP_RS15670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DP_RS15685	COG4120	Belongs to the binding-protein-dependent transport system permease family
DP_RS15690	COG1116	anion transmembrane transporter activity
DP_RS15695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DP_RS15720	COG0564	pseudouridine synthase activity
DP_RS15725	COG5001	Diguanylate cyclase
DP_RS15750	COG0544	peptidyl-prolyl cis-trans isomerase activity
DP_RS15760	COG2081	HI0933 family
DP_RS15765	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DP_RS15820	COG2852	Protein conserved in bacteria
DP_RS16340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DP_RS16395	COG1216	Glycosyl transferase, family 2
DP_RS16410	COG1215	transferase activity, transferring glycosyl groups
DP_RS16445	COG3706	GGDEF domain
DP_RS16455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DP_RS16470	COG2205	protein histidine kinase activity
DP_RS16470	COG2198	Histidine kinase
DP_RS16470	COG0784	Response regulator, receiver
DP_RS16480	COG2770	Histidine kinase
DP_RS16480	COG3437	response regulator, receiver
DP_RS16485	COG2770	Histidine kinase
DP_RS16485	COG3437	response regulator, receiver
DP_RS16530	COG0840	transmembrane signaling receptor activity
DP_RS16535	COG0840	transmembrane signaling receptor activity
DP_RS16545	COG0617	tRNA 3'-terminal CCA addition
DP_RS16575	COG2264	protein methyltransferase activity
DP_RS16580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DP_RS16585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DP_RS16615	COG4657	Part of a membrane complex involved in electron transport
DP_RS16620	COG0470	DNA polymerase III
DP_RS16630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DP_RS16665	COG0739	heme binding
DP_RS16670	COG0668	transmembrane transport
DP_RS16675	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DP_RS16680	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DP_RS16685	COG2885	chlorophyll binding
DP_RS16690	COG0741	lytic transglycosylase activity
DP_RS16695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DP_RS16790	COG0826	peptidase U32
DP_RS16805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DP_RS16810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DP_RS16830	COG0668	transmembrane transport
DP_RS16840	COG0745	RESPONSE REGULATOR receiver
DP_RS16850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DP_RS16865	COG2208	phosphoserine phosphatase activity
DP_RS16910	COG0406	alpha-ribazole phosphatase activity
DP_RS16915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DP_RS16920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DP_RS16950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DP_RS16960	COG3706	GGDEF domain
DP_RS16980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DP_RS16990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DP_RS16990	COG0116	Belongs to the methyltransferase superfamily
DP_RS17000	COG3706	GGDEF domain
DP_RS17005	COG1144	Oxidoreductase
DP_RS17040	COG0515	serine threonine protein kinase
DP_RS17040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DP_RS17065	COG0631	protein serine/threonine phosphatase activity
DP_RS17070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DP_RS17085	COG1749	Flagellar hook protein flgE
DP_RS17125	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DP_RS17145	COG0037	tRNA processing
DP_RS17160	COG0840	transmembrane signaling receptor activity
DP_RS17165	COG1530	ribonuclease E activity