locus-tag	class	description
B0537_RS00005	COG1116	anion transmembrane transporter activity
B0537_RS00035	COG4175	Glycine betaine
B0537_RS00035	COG0517	IMP dehydrogenase activity
B0537_RS00040	COG1510	regulation of RNA biosynthetic process
B0537_RS00060	COG2358	TRAP transporter, solute receptor (TAXI family
B0537_RS00085	COG0551	DNA topoisomerase type I activity
B0537_RS00085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B0537_RS00090	COG0531	amino acid
B0537_RS00100	COG3283	Transcriptional regulator of aromatic amino acids metabolism
B0537_RS00120	COG0564	pseudouridine synthase activity
B0537_RS00135	COG0840	transmembrane signaling receptor activity
B0537_RS00150	COG0351	phosphomethylpyrimidine kinase
B0537_RS00155	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B0537_RS00160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B0537_RS00165	COG1162	GTPase activity
B0537_RS00175	COG1378	Sugar-specific transcriptional regulator TrmB
B0537_RS00180	COG0778	Nitroreductase
B0537_RS00210	COG0778	Nitroreductase
B0537_RS00215	COG0840	transmembrane signaling receptor activity
B0537_RS00230	COG2972	Histidine kinase
B0537_RS00240	COG4869	propanediol catabolic process
B0537_RS00245	COG1454	alcohol dehydrogenase
B0537_RS00245	COG1012	belongs to the aldehyde dehydrogenase family
B0537_RS00250	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
B0537_RS00265	COG4656	Part of a membrane complex involved in electron transport
B0537_RS00270	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
B0537_RS00300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B0537_RS00305	COG1882	Formate acetyltransferase
B0537_RS00315	COG1454	alcohol dehydrogenase
B0537_RS00315	COG1012	belongs to the aldehyde dehydrogenase family
B0537_RS00345	COG1573	uracil-dna glycosylase
B0537_RS00350	COG0432	Pfam Uncharacterised protein family UPF0047
B0537_RS00360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B0537_RS00365	COG1215	transferase activity, transferring glycosyl groups
B0537_RS00410	COG2824	Alkylphosphonate utilization operon protein PhnA
B0537_RS00415	COG1757	Na H antiporter
B0537_RS00425	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B0537_RS00430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B0537_RS00445	COG0739	heme binding
B0537_RS00505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B0537_RS00510	COG0305	Participates in initiation and elongation during chromosome replication
B0537_RS00515	COG0470	DNA polymerase III
B0537_RS00515	COG1067	ATP-dependent peptidase activity
B0537_RS00520	COG0359	binds to the 23S rRNA
B0537_RS00525	COG4241	membrane
B0537_RS00530	COG2814	Major facilitator Superfamily
B0537_RS00535	COG1846	Transcriptional regulator
B0537_RS00540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B0537_RS00545	COG0629	single-stranded DNA binding
B0537_RS00550	COG0360	Binds together with S18 to 16S ribosomal RNA
B0537_RS00555	COG4481	Protein conserved in bacteria
B0537_RS00560	COG0668	transmembrane transport
B0537_RS00565	COG1362	aminopeptidase activity
B0537_RS00575	COG3949	Membrane
B0537_RS00595	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
B0537_RS00600	COG1307	EDD domain protein, DegV family
B0537_RS00610	COG1475	DNA binding
B0537_RS00615	COG1192	Involved in chromosome partitioning
B0537_RS00620	COG0357	Ribosomal RNA small subunit methyltransferase G
B0537_RS00625	COG0445	tRNA wobble uridine modification
B0537_RS00630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B0537_RS00635	COG1847	R3H domain protein
B0537_RS00640	COG0706	membrane insertase activity
B0537_RS00645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B0537_RS00650	COG0594	ribonuclease P activity
B0537_RS00655	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B0537_RS00660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B0537_RS00665	COG0592	DNA-directed DNA polymerase activity
B0537_RS00675	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B0537_RS00685	COG0187	DNA topoisomerase II activity
B0537_RS00690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B0537_RS00725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B0537_RS00735	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B0537_RS00740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B0537_RS00745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B0537_RS00790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B0537_RS00795	COG3328	transposase activity
B0537_RS00800	COG0590	tRNA wobble adenosine to inosine editing
B0537_RS00835	COG2801	Transposase and inactivated derivatives
B0537_RS00870	COG1690	Belongs to the RtcB family
B0537_RS00875	COG1205	dead DEAH box helicase
B0537_RS00875	COG1111	helicase
B0537_RS00880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B0537_RS00885	COG4191	Histidine kinase
B0537_RS00895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B0537_RS00910	COG2207	Transcriptional regulator
B0537_RS00915	COG0596	Alpha beta hydrolase
B0537_RS00950	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B0537_RS00955	COG0022	dehydrogenase e1 component
B0537_RS00975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B0537_RS00980	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
B0537_RS00985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B0537_RS00990	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B0537_RS00995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B0537_RS01035	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B0537_RS01050	COG0697	spore germination
B0537_RS01070	COG1982	Orn Lys Arg decarboxylase major
B0537_RS01075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B0537_RS01080	COG0470	DNA polymerase III
B0537_RS01085	COG1774	PSP1 C-terminal conserved region
B0537_RS01095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B0537_RS01105	COG2002	toxin-antitoxin pair type II binding
B0537_RS01110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B0537_RS01110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B0537_RS01115	COG0084	hydrolase, TatD family'
B0537_RS01130	COG3583	domain protein
B0537_RS01130	COG3584	3D domain protein
B0537_RS01135	COG1388	LysM domain
B0537_RS01135	COG3584	3D domain protein
B0537_RS01145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B0537_RS01160	COG2340	Cysteine-rich secretory protein family
B0537_RS01165	COG1388	LysM domain
B0537_RS01180	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B0537_RS01185	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B0537_RS01200	COG1404	Belongs to the peptidase S8 family
B0537_RS01215	COG1115	amino acid carrier protein
B0537_RS01220	COG1376	ErfK ybiS ycfS ynhG family protein
B0537_RS01225	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B0537_RS01230	COG1802	Transcriptional regulator
B0537_RS01240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B0537_RS01245	COG2088	sporulation resulting in formation of a cellular spore
B0537_RS01250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B0537_RS01255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B0537_RS01295	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B0537_RS01300	COG0193	aminoacyl-tRNA hydrolase activity
B0537_RS01310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B0537_RS01315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B0537_RS01320	COG2002	toxin-antitoxin pair type II binding
B0537_RS01325	COG3956	TIGRFAM MazG family protein
B0537_RS01330	COG0776	regulation of translation
B0537_RS01335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B0537_RS01340	COG2385	sporulation resulting in formation of a cellular spore
B0537_RS01360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B0537_RS01365	COG1098	S1 RNA binding domain
B0537_RS01370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B0537_RS01370	COG0248	Ppx GppA phosphatase
B0537_RS01375	COG2208	phosphoserine phosphatase activity
B0537_RS01380	COG0037	tRNA processing
B0537_RS01385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B0537_RS01390	COG0105	UTP biosynthetic process
B0537_RS01395	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B0537_RS01400	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B0537_RS01400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B0537_RS01405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B0537_RS01425	COG0693	protein deglycase activity
B0537_RS01440	COG3829	transcription factor binding
B0537_RS01445	COG1882	Formate acetyltransferase
B0537_RS01450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B0537_RS01470	COG1349	DNA-binding transcription factor activity
B0537_RS01550	COG1691	(AIR) carboxylase
B0537_RS01555	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
B0537_RS01560	COG1606	tRNA processing
B0537_RS01570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B0537_RS01575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B0537_RS01580	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B0537_RS01595	COG2909	trisaccharide binding
B0537_RS01600	COG1929	Belongs to the glycerate kinase type-1 family
B0537_RS01605	COG0617	tRNA 3'-terminal CCA addition
B0537_RS01620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B0537_RS01625	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B0537_RS01630	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B0537_RS01635	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B0537_RS01640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B0537_RS01660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B0537_RS01665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B0537_RS01675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B0537_RS01680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B0537_RS01735	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B0537_RS01740	COG0542	response to heat
B0537_RS01750	COG3344	reverse transcriptase
B0537_RS01755	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B0537_RS01760	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B0537_RS01770	COG1329	Transcriptional regulator
B0537_RS01775	COG4956	integral membrane protein (PIN domain superfamily)
B0537_RS01780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B0537_RS01785	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B0537_RS01800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B0537_RS01805	COG1045	serine acetyltransferase
B0537_RS01810	COG0215	cysteine-tRNA ligase activity
B0537_RS01815	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B0537_RS01820	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B0537_RS01830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B0537_RS01865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B0537_RS01870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B0537_RS01880	COG0250	Participates in transcription elongation, termination and antitermination
B0537_RS01885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B0537_RS01890	COG0081	regulation of translation
B0537_RS01895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B0537_RS01900	COG0222	ribosome binding
B0537_RS01905	COG0085	RNA polymerase activity
B0537_RS01910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B0537_RS01915	COG1358	cellular component organization or biogenesis
B0537_RS01920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B0537_RS01925	COG0049	tRNA binding
B0537_RS01930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B0537_RS01935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B0537_RS01940	COG0051	transcription antitermination factor activity, RNA binding
B0537_RS01945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B0537_RS01950	COG0088	Forms part of the polypeptide exit tunnel
B0537_RS01955	COG0089	rRNA binding
B0537_RS01960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B0537_RS01965	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B0537_RS01970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B0537_RS01975	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B0537_RS01980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B0537_RS01985	COG0255	Belongs to the universal ribosomal protein uL29 family
B0537_RS01990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B0537_RS01995	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B0537_RS02000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B0537_RS02005	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B0537_RS02010	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B0537_RS02015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B0537_RS02020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B0537_RS02025	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B0537_RS02030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B0537_RS02035	COG1841	ribosomal large subunit assembly
B0537_RS02040	COG0200	Binds to the 23S rRNA
B0537_RS02045	COG0201	protein transport
B0537_RS02060	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B0537_RS02065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B0537_RS02070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B0537_RS02075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B0537_RS02080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B0537_RS02085	COG0202	RNA polymerase activity
B0537_RS02090	COG0203	ribosomal protein L17
B0537_RS02095	COG1122	ATPase activity
B0537_RS02100	COG1122	ATPase activity
B0537_RS02105	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B0537_RS02110	COG0101	tRNA pseudouridine synthase activity
B0537_RS02115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B0537_RS02120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B0537_RS02145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B0537_RS02165	COG3885	ferrous iron binding
B0537_RS02165	COG2078	PFAM AMMECR1 domain protein
B0537_RS02175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B0537_RS02180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B0537_RS02185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B0537_RS02190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B0537_RS02195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B0537_RS02200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B0537_RS02205	COG0137	argininosuccinate synthase activity
B0537_RS02210	COG0165	Argininosuccinate lyase
B0537_RS02215	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B0537_RS02215	COG2199	diguanylate cyclase activity
B0537_RS02225	COG0129	dihydroxy-acid dehydratase activity
B0537_RS02230	COG0028	Belongs to the TPP enzyme family
B0537_RS02235	COG0440	acetolactate synthase activity
B0537_RS02240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B0537_RS02245	COG0028	Belongs to the TPP enzyme family
B0537_RS02250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B0537_RS02255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B0537_RS02260	COG0066	3-isopropylmalate dehydratase activity
B0537_RS02265	COG0473	3-isopropylmalate dehydrogenase activity
B0537_RS02270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B0537_RS02280	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B0537_RS02290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B0537_RS02295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B0537_RS02300	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B0537_RS02365	COG1937	Protein conserved in bacteria
B0537_RS02375	COG4372	Transposase
B0537_RS02430	COG0509	glycine decarboxylation via glycine cleavage system
B0537_RS02450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B0537_RS02455	COG1484	DNA-dependent DNA replication
B0537_RS02505	COG0840	transmembrane signaling receptor activity
B0537_RS02520	COG5002	protein histidine kinase activity
B0537_RS02530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B0537_RS02570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B0537_RS02580	COG3852	Histidine kinase
B0537_RS02585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B0537_RS02600	COG0840	transmembrane signaling receptor activity
B0537_RS02620	COG0697	spore germination
B0537_RS02650	COG1846	Transcriptional regulator
B0537_RS02660	COG1132	(ABC) transporter
B0537_RS02665	COG0488	(ABC) transporter
B0537_RS02695	COG0346	lactoylglutathione lyase activity
B0537_RS02700	COG0840	transmembrane signaling receptor activity
B0537_RS02705	COG0534	Mate efflux family protein
B0537_RS02735	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B0537_RS02735	COG0493	'glutamate synthase
B0537_RS02745	COG2226	methyltransferase
B0537_RS02755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B0537_RS02760	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
B0537_RS02765	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B0537_RS02765	COG3608	succinylglutamate desuccinylase aspartoacylase
B0537_RS02770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B0537_RS02785	COG1012	belongs to the aldehyde dehydrogenase family
B0537_RS02800	COG0745	RESPONSE REGULATOR receiver
B0537_RS02805	COG5002	protein histidine kinase activity
B0537_RS02820	COG3118	belongs to the thioredoxin family
B0537_RS02835	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B0537_RS02840	COG0477	Major facilitator Superfamily
B0537_RS02845	COG2814	Major facilitator Superfamily
B0537_RS02850	COG2086	electron transfer activity
B0537_RS02855	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B0537_RS02875	COG1575	Belongs to the MenA family. Type 1 subfamily
B0537_RS02885	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B0537_RS02890	COG1309	transcriptional regulator
B0537_RS02895	COG0840	transmembrane signaling receptor activity
B0537_RS02900	COG0583	DNA-binding transcription factor activity
B0537_RS02905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B0537_RS02910	COG0321	lipoyl(octanoyl) transferase activity
B0537_RS02915	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B0537_RS02935	COG1136	(ABC) transporter
B0537_RS02940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B0537_RS02945	COG1136	(ABC) transporter
B0537_RS02945	COG0577	efflux transmembrane transporter activity
B0537_RS02955	COG0477	Major facilitator Superfamily
B0537_RS02965	COG0745	RESPONSE REGULATOR receiver
B0537_RS02970	COG2770	Histidine kinase
B0537_RS02970	COG2205	protein histidine kinase activity
B0537_RS02975	COG1307	EDD domain protein, DegV family
B0537_RS02990	COG1592	Rubrerythrin
B0537_RS02990	COG1773	rubredoxin
B0537_RS03005	COG0339	signal peptide processing
B0537_RS03030	COG2855	membrane
B0537_RS03045	COG0861	Integral membrane protein TerC family
B0537_RS03050	COG1253	flavin adenine dinucleotide binding
B0537_RS03055	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B0537_RS03110	COG1252	NADH dehydrogenase
B0537_RS03140	COG0688	phosphatidylethanolamine metabolic process
B0537_RS03145	COG1285	pathogenesis
B0537_RS03150	COG0517	IMP dehydrogenase activity
B0537_RS03180	COG1566	PFAM secretion protein HlyD family protein
B0537_RS03225	COG5557	Pfam Polysulphide reductase, NrfD
B0537_RS03230	COG0437	4 iron, 4 sulfur cluster binding
B0537_RS03230	COG3064	Membrane
B0537_RS03260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B0537_RS03270	COG1950	PFAM Membrane protein of
B0537_RS03290	COG1217	gtp-binding protein TYPA
B0537_RS03295	COG1304	FMN binding
B0537_RS03330	COG0747	negative chemotaxis
B0537_RS03340	COG4572	Cation transport regulator
B0537_RS03350	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B0537_RS03385	COG0756	dUTP diphosphatase activity
B0537_RS03490	COG5002	protein histidine kinase activity
B0537_RS03490	COG3850	Histidine kinase
B0537_RS03495	COG1136	(ABC) transporter
B0537_RS03520	COG0412	Dienelactone hydrolase
B0537_RS03525	COG1215	transferase activity, transferring glycosyl groups
B0537_RS03540	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B0537_RS03550	COG5002	protein histidine kinase activity
B0537_RS03560	COG0824	Thioesterase
B0537_RS03565	COG0493	'glutamate synthase
B0537_RS03570	COG1151	hydroxylamine reductase activity
B0537_RS03590	COG0589	response to stress
B0537_RS03595	COG2962	Rard protein
B0537_RS03610	COG0745	RESPONSE REGULATOR receiver
B0537_RS03630	COG2048	Heterodisulfide reductase, subunit B
B0537_RS03635	COG2046	Belongs to the sulfate adenylyltransferase family
B0537_RS03650	COG1233	COG1233 Phytoene dehydrogenase and related
B0537_RS03665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B0537_RS03670	COG3875	lactate racemase activity
B0537_RS03680	COG2814	Major facilitator Superfamily
B0537_RS03685	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B0537_RS03690	COG3858	chitin binding
B0537_RS03705	COG1686	Belongs to the peptidase S11 family
B0537_RS03710	COG0735	belongs to the Fur family
B0537_RS03720	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B0537_RS03720	COG1918	ferrous iron import across plasma membrane
B0537_RS03735	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B0537_RS03740	COG2001	Belongs to the MraZ family
B0537_RS03745	COG0275	rRNA processing
B0537_RS03755	COG0768	penicillin binding
B0537_RS03760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B0537_RS03765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B0537_RS03770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B0537_RS03775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B0537_RS03780	COG0772	Belongs to the SEDS family
B0537_RS03785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B0537_RS03790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B0537_RS03795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B0537_RS03800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B0537_RS03805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B0537_RS03810	COG3879	Bacterial protein of unknown function (DUF881)
B0537_RS03820	COG3856	small basic protein
B0537_RS03825	COG0849	cell division
B0537_RS03830	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B0537_RS03845	COG1191	sigma factor activity
B0537_RS03850	COG1191	sigma factor activity
B0537_RS03855	COG1873	PFAM PRC-barrel domain
B0537_RS03865	COG1139	Iron-sulfur cluster binding protein
B0537_RS03870	COG2226	methyltransferase
B0537_RS03880	COG1533	DNA photolyase activity
B0537_RS03885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B0537_RS03930	COG1151	hydroxylamine reductase activity
B0537_RS03935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B0537_RS03950	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
B0537_RS03955	COG1333	cytochrome c biogenesis protein
B0537_RS03960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B0537_RS03980	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B0537_RS03985	COG1496	oxidoreductase activity
B0537_RS03990	COG0745	RESPONSE REGULATOR receiver
B0537_RS03995	COG5002	protein histidine kinase activity
B0537_RS04000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B0537_RS04015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B0537_RS04020	COG1799	cell septum assembly
B0537_RS04025	COG0762	integral membrane protein
B0537_RS04035	COG3599	regulation of cell shape
B0537_RS04050	COG0303	'Molybdopterin
B0537_RS04065	COG3383	formate dehydrogenase (NAD+) activity
B0537_RS04065	COG0243	molybdopterin cofactor binding
B0537_RS04070	COG0437	4 iron, 4 sulfur cluster binding
B0537_RS04075	COG5557	Pfam Polysulphide reductase, NrfD
B0537_RS04085	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B0537_RS04095	COG0765	amino acid transport
B0537_RS04100	COG1126	abc transporter atp-binding protein
B0537_RS04110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B0537_RS04115	COG0509	glycine decarboxylation via glycine cleavage system
B0537_RS04120	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B0537_RS04125	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B0537_RS04130	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B0537_RS04140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B0537_RS04145	COG0765	amino acid transport
B0537_RS04160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B0537_RS04160	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B0537_RS04165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B0537_RS04170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B0537_RS04175	COG1490	D-aminoacyl-tRNA deacylase activity
B0537_RS04180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B0537_RS04195	COG2720	vancomycin resistance protein
B0537_RS04200	COG0622	Phosphoesterase
B0537_RS04220	COG0546	phosphoglycolate phosphatase activity
B0537_RS04225	COG4224	UPF0291 protein
B0537_RS04230	COG0124	histidyl-tRNA synthetase
B0537_RS04235	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B0537_RS04245	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B0537_RS04250	COG3118	belongs to the thioredoxin family
B0537_RS04255	COG1959	2 iron, 2 sulfur cluster binding
B0537_RS04260	COG1104	cysteine desulfurase activity
B0537_RS04265	COG0822	iron-sulfur transferase activity
B0537_RS04270	COG0482	sulfurtransferase activity
B0537_RS04275	COG0628	permease
B0537_RS04280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B0537_RS04295	COG4472	Bacterial protein of unknown function (DUF965)
B0537_RS04305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B0537_RS04310	COG3906	Belongs to the UPF0473 family
B0537_RS04315	COG2720	vancomycin resistance protein
B0537_RS04320	COG3290	protein histidine kinase activity
B0537_RS04320	COG0840	transmembrane signaling receptor activity
B0537_RS04340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B0537_RS04345	COG0826	peptidase U32
B0537_RS04350	COG0768	penicillin binding
B0537_RS04355	COG1395	domain, Protein
B0537_RS04360	COG3118	belongs to the thioredoxin family
B0537_RS04385	COG2203	Gaf domain
B0537_RS04385	COG3706	GGDEF domain
B0537_RS04385	COG4251	negative regulation of phosphorylation
B0537_RS04385	COG5001	Diguanylate cyclase
B0537_RS04390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B0537_RS04395	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B0537_RS04450	COG1518	maintenance of DNA repeat elements
B0537_RS04455	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B0537_RS04530	COG1725	Transcriptional regulator
B0537_RS04535	COG1131	(ABC) transporter
B0537_RS04550	COG3328	transposase activity
B0537_RS04690	COG1819	glycosyl
B0537_RS04730	COG3409	Peptidoglycan-binding domain 1 protein
B0537_RS04730	COG5632	N-Acetylmuramoyl-L-alanine amidase
B0537_RS04735	COG1388	LysM domain
B0537_RS04735	COG0791	NLP P60 protein
B0537_RS04780	COG4372	Transposase
B0537_RS04800	COG1686	Belongs to the peptidase S11 family
B0537_RS04825	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B0537_RS04830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B0537_RS04835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B0537_RS04840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B0537_RS04845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B0537_RS04850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B0537_RS04860	COG1459	type II secretion system
B0537_RS04870	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B0537_RS04910	COG0312	modulator of DNA gyrase
B0537_RS04920	COG0312	modulator of DNA gyrase
B0537_RS04925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B0537_RS04930	COG0006	proline dipeptidase activity
B0537_RS04935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B0537_RS04945	COG0077	Prephenate dehydratase
B0537_RS04945	COG1605	Chorismate mutase
B0537_RS04950	COG0446	pyridine nucleotide-disulphide oxidoreductase
B0537_RS04955	COG3854	ATPases associated with a variety of cellular activities
B0537_RS05000	COG5016	pyruvate
B0537_RS05000	COG0511	ligase activity, forming carbon-carbon bonds
B0537_RS05005	COG0439	Biotin carboxylase
B0537_RS05010	COG1302	Protein conserved in bacteria
B0537_RS05025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B0537_RS05035	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B0537_RS05035	COG0493	'glutamate synthase
B0537_RS05040	COG1570	exodeoxyribonuclease VII activity
B0537_RS05045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B0537_RS05055	COG1722	exodeoxyribonuclease VII activity
B0537_RS05070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B0537_RS05075	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B0537_RS05085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B0537_RS05095	COG1438	arginine binding
B0537_RS05100	COG0497	DNA recombination
B0537_RS05105	COG0750	zinc metalloprotease
B0537_RS05110	COG0745	RESPONSE REGULATOR receiver
B0537_RS05130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B0537_RS05160	COG2195	Cleaves the N-terminal amino acid of tripeptides
B0537_RS05180	COG1300	Membrane
B0537_RS05190	COG2707	UPF0756 membrane protein
B0537_RS05205	COG4974	Belongs to the 'phage' integrase family
B0537_RS05210	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B0537_RS05220	COG1686	Belongs to the peptidase S11 family
B0537_RS05230	COG2172	sigma factor antagonist activity
B0537_RS05245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B0537_RS05260	COG0697	spore germination
B0537_RS05265	COG0746	molybdenum cofactor guanylyltransferase activity
B0537_RS05270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B0537_RS05285	COG0437	4 iron, 4 sulfur cluster binding
B0537_RS05285	COG3064	Membrane
B0537_RS05290	COG5557	Pfam Polysulphide reductase, NrfD
B0537_RS05300	COG0805	protein transport
B0537_RS05305	COG0733	neurotransmitter:sodium symporter activity
B0537_RS05340	COG1924	4 iron, 4 sulfur cluster binding
B0537_RS05350	COG2183	response to ionizing radiation
B0537_RS05375	COG0697	spore germination
B0537_RS05385	COG0019	diaminopimelate decarboxylase activity
B0537_RS05390	COG3620	sequence-specific DNA binding
B0537_RS05390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B0537_RS05390	COG0617	tRNA 3'-terminal CCA addition
B0537_RS05395	COG1994	Peptidase M50
B0537_RS05400	COG0180	Tryptophanyl-tRNA synthetase
B0537_RS05410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B0537_RS05430	COG3874	Sporulation protein YtfJ
B0537_RS05435	COG3852	Histidine kinase
B0537_RS05440	COG2715	membrane protein required for spore maturation
B0537_RS05445	COG0700	Nucleoside recognition
B0537_RS05450	COG1187	pseudouridine synthase activity
B0537_RS05480	COG0436	Aminotransferase
B0537_RS05485	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B0537_RS05490	COG0287	Prephenate dehydrogenase
B0537_RS05495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B0537_RS05500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B0537_RS05505	COG0204	Acyl-transferase
B0537_RS05510	COG0539	negative regulation of cytoplasmic translation
B0537_RS05510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B0537_RS05540	COG1160	GTP binding
B0537_RS05545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B0537_RS05550	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B0537_RS05560	COG3328	transposase activity
B0537_RS05565	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B0537_RS05570	COG4492	Belongs to the UPF0735 family
B0537_RS05575	COG0460	homoserine dehydrogenase
B0537_RS05580	COG0083	homoserine kinase activity
B0537_RS05590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B0537_RS05595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B0537_RS05600	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B0537_RS05625	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
B0537_RS05640	COG0840	transmembrane signaling receptor activity
B0537_RS05645	COG2720	vancomycin resistance protein
B0537_RS05650	COG0248	Ppx GppA phosphatase
B0537_RS05680	COG0428	transporter
B0537_RS05685	COG0840	transmembrane signaling receptor activity
B0537_RS05735	COG0531	amino acid
B0537_RS05740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B0537_RS05745	COG2357	RelA SpoT domain protein
B0537_RS05770	COG0681	Belongs to the peptidase S26 family
B0537_RS05780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B0537_RS05790	COG2814	Major facilitator Superfamily
B0537_RS05815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B0537_RS05820	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B0537_RS05830	COG0425	Belongs to the sulfur carrier protein TusA family
B0537_RS05840	COG1122	ATPase activity
B0537_RS05845	COG1122	ATPase activity
B0537_RS05850	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B0537_RS05875	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B0537_RS05875	COG0493	'glutamate synthase
B0537_RS05895	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B0537_RS05900	COG1846	Transcriptional regulator
B0537_RS05905	COG1760	l-serine dehydratase
B0537_RS05910	COG1760	l-serine dehydratase
B0537_RS05945	COG1304	FMN binding
B0537_RS05950	COG1376	ErfK ybiS ycfS ynhG family protein
B0537_RS05955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B0537_RS05985	COG1414	Transcriptional regulator
B0537_RS05990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B0537_RS05995	COG2233	PERMEase
B0537_RS06000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B0537_RS06020	COG0513	Belongs to the DEAD box helicase family
B0537_RS06035	COG3901	Regulator of nitric oxide reductase transcription
B0537_RS06035	COG0348	domain, Protein
B0537_RS06045	COG1461	Dihydroxyacetone kinase
B0537_RS06060	COG0501	Belongs to the peptidase M48B family
B0537_RS06080	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
B0537_RS06085	COG1924	4 iron, 4 sulfur cluster binding
B0537_RS06090	COG0017	Asparaginyl-tRNA synthetase
B0537_RS06105	COG0632	four-way junction helicase activity
B0537_RS06135	COG3546	catalase activity
B0537_RS06155	COG0735	belongs to the Fur family
B0537_RS06160	COG0803	Belongs to the bacterial solute-binding protein 9 family
B0537_RS06165	COG1121	(ABC) transporter
B0537_RS06170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B0537_RS06180	COG3852	Histidine kinase
B0537_RS06185	COG2204	response regulator
B0537_RS06200	COG0427	acetyl-CoA hydrolase
B0537_RS06210	COG0730	response to heat
B0537_RS06215	COG2233	PERMEase
B0537_RS06220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B0537_RS06230	COG1799	cell septum assembly
B0537_RS06235	COG0037	tRNA processing
B0537_RS06295	COG3773	Cell wall hydrolase
B0537_RS06295	COG3409	Peptidoglycan-binding domain 1 protein
B0537_RS06310	COG1983	PspC domain protein
B0537_RS06320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B0537_RS06325	COG1342	Belongs to the UPF0251 family
B0537_RS06345	COG0489	protein tyrosine kinase activity
B0537_RS06360	COG0427	acetyl-CoA hydrolase
B0537_RS06370	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B0537_RS06385	COG0640	Transcriptional regulator
B0537_RS06395	COG0402	S-adenosylhomocysteine deaminase activity
B0537_RS06410	COG0564	pseudouridine synthase activity
B0537_RS06425	COG1494	fructose-1,6-bisphosphatase
B0537_RS06445	COG1131	(ABC) transporter
B0537_RS06455	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B0537_RS06460	COG1242	4 iron, 4 sulfur cluster binding
B0537_RS06465	COG1067	ATP-dependent peptidase activity
B0537_RS06480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B0537_RS06505	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B0537_RS06510	COG0644	oxidoreductase
B0537_RS06520	COG1151	hydroxylamine reductase activity
B0537_RS06540	COG1671	Belongs to the UPF0178 family
B0537_RS06545	COG0277	FAD linked oxidase domain protein
B0537_RS06555	COG0833	amino acid
B0537_RS06560	COG2340	Cysteine-rich secretory protein family
B0537_RS06565	COG1126	abc transporter atp-binding protein
B0537_RS06570	COG0765	amino acid transport
B0537_RS06575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B0537_RS06580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B0537_RS06635	COG0732	type I restriction modification DNA specificity domain
B0537_RS06655	COG2076	Multidrug Resistance protein
B0537_RS06660	COG2076	Multidrug Resistance protein
B0537_RS06670	COG5337	Spore coat protein CotH
B0537_RS06685	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B0537_RS06700	COG0573	inorganic phosphate transmembrane transporter activity
B0537_RS06710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B0537_RS06725	COG4106	trans-aconitate 2-methyltransferase activity
B0537_RS06735	COG0463	Glycosyl transferase, family 2
B0537_RS06735	COG1216	Glycosyl transferase, family 2
B0537_RS06750	COG0463	Glycosyl transferase, family 2
B0537_RS06750	COG1216	Glycosyl transferase, family 2
B0537_RS06760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B0537_RS06765	COG0436	Aminotransferase
B0537_RS06775	COG0028	Belongs to the TPP enzyme family
B0537_RS06785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B0537_RS06815	COG0457	Tetratricopeptide repeat
B0537_RS06815	COG0463	Glycosyl transferase, family 2
B0537_RS06845	COG3103	Sh3 type 3 domain protein
B0537_RS06845	COG1388	LysM domain
B0537_RS06845	COG0791	NLP P60 protein
B0537_RS06855	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B0537_RS06860	COG1074	ATP-dependent DNA helicase activity
B0537_RS06890	COG2813	Specifically methylates the guanine in position
B0537_RS06950	COG0534	Mate efflux family protein
B0537_RS06955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B0537_RS06960	COG0840	transmembrane signaling receptor activity
B0537_RS06970	COG0488	(ABC) transporter
B0537_RS06990	COG2827	Endonuclease containing a URI domain
B0537_RS06995	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B0537_RS07000	COG2081	HI0933 family
B0537_RS07020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B0537_RS07025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B0537_RS07030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B0537_RS07040	COG0247	lactate metabolic process
B0537_RS07060	COG5557	Pfam Polysulphide reductase, NrfD
B0537_RS07065	COG3064	Membrane
B0537_RS07065	COG0437	4 iron, 4 sulfur cluster binding
B0537_RS07075	COG0583	DNA-binding transcription factor activity
B0537_RS07080	COG4122	O-methyltransferase activity
B0537_RS07100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B0537_RS07110	COG2855	membrane
B0537_RS07115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B0537_RS07120	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B0537_RS07125	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B0537_RS07130	COG0297	glycogen (starch) synthase activity
B0537_RS07135	COG3103	Sh3 type 3 domain protein
B0537_RS07135	COG0366	Alpha amylase catalytic
B0537_RS07145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B0537_RS07145	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B0537_RS07165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B0537_RS07175	COG2323	membrane
B0537_RS07190	COG2323	membrane
B0537_RS07205	COG0326	Molecular chaperone. Has ATPase activity
B0537_RS07215	COG0840	transmembrane signaling receptor activity
B0537_RS07225	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B0537_RS07235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B0537_RS07270	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B0537_RS07285	COG3852	Histidine kinase
B0537_RS07290	COG1575	Belongs to the MenA family. Type 1 subfamily
B0537_RS07300	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B0537_RS07305	COG3852	Histidine kinase
B0537_RS07310	COG2860	membrane
B0537_RS07325	COG5002	protein histidine kinase activity
B0537_RS07325	COG5001	Diguanylate cyclase
B0537_RS07335	COG5002	protein histidine kinase activity
B0537_RS07335	COG5001	Diguanylate cyclase
B0537_RS07335	COG3447	MASE1 domain protein
B0537_RS07340	COG1238	metal cluster binding
B0537_RS07345	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B0537_RS07345	COG3608	succinylglutamate desuccinylase aspartoacylase
B0537_RS07350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B0537_RS07370	COG0251	oxidation-reduction process
B0537_RS07385	COG0351	phosphomethylpyrimidine kinase
B0537_RS07405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B0537_RS07410	COG1131	(ABC) transporter
B0537_RS07415	COG1131	(ABC) transporter
B0537_RS07420	COG0842	Transport permease protein
B0537_RS07425	COG1309	transcriptional regulator
B0537_RS07430	COG0840	transmembrane signaling receptor activity
B0537_RS07430	COG3290	protein histidine kinase activity
B0537_RS07435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B0537_RS07445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B0537_RS07455	COG0237	dephospho-CoA kinase activity
B0537_RS07460	COG1971	Probably functions as a manganese efflux pump
B0537_RS07465	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B0537_RS07475	COG3409	Peptidoglycan-binding domain 1 protein
B0537_RS07475	COG0793	Belongs to the peptidase S41A family
B0537_RS07480	COG0586	Pfam SNARE associated Golgi protein
B0537_RS07490	COG0398	Pfam SNARE associated Golgi protein
B0537_RS07510	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
B0537_RS07515	COG1333	cytochrome c biogenesis protein
B0537_RS07520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B0537_RS07530	COG1686	Belongs to the peptidase S11 family
B0537_RS07560	COG1115	amino acid carrier protein
B0537_RS07585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B0537_RS07590	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B0537_RS07595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B0537_RS07600	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B0537_RS07605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B0537_RS07610	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B0537_RS07615	COG0072	phenylalanine-tRNA ligase activity
B0537_RS07615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B0537_RS07620	COG0564	pseudouridine synthase activity
B0537_RS07625	COG5002	protein histidine kinase activity
B0537_RS07630	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B0537_RS07635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B0537_RS07635	COG1796	DNA polymerase
B0537_RS07640	COG2094	Belongs to the DNA glycosylase MPG family
B0537_RS07650	COG0826	peptidase U32
B0537_RS07655	COG1193	negative regulation of DNA recombination
B0537_RS07660	COG1271	oxidase subunit
B0537_RS07665	COG1294	oxidase, subunit
B0537_RS07670	COG4988	ABC transporter
B0537_RS07675	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B0537_RS07685	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B0537_RS07695	COG2032	superoxide dismutase activity
B0537_RS07710	COG1131	(ABC) transporter
B0537_RS07720	COG1757	Na H antiporter
B0537_RS07730	COG4499	WXG100 protein secretion system (Wss), protein YukC
B0537_RS07730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B0537_RS07735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B0537_RS07765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B0537_RS07765	COG2111	Na H antiporter
B0537_RS07770	COG2111	Na H antiporter
B0537_RS07775	COG1006	Multisubunit Na H antiporter MnhC subunit
B0537_RS07780	COG0651	ATP synthesis coupled electron transport
B0537_RS07785	COG1863	multisubunit Na H antiporter MnhE subunit
B0537_RS07790	COG2212	antiporter activity
B0537_RS07795	COG1320	monovalent cation:proton antiporter activity
B0537_RS07855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B0537_RS07860	COG0217	transcriptional regulatory protein
B0537_RS07870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B0537_RS07875	COG0632	four-way junction helicase activity
B0537_RS07880	COG2255	four-way junction helicase activity
B0537_RS07885	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B0537_RS07895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B0537_RS07900	COG0343	queuine tRNA-ribosyltransferase activity
B0537_RS07905	COG1862	Preprotein translocase
B0537_RS07915	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B0537_RS07920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B0537_RS07925	COG3830	Belongs to the UPF0237 family
B0537_RS07930	COG2848	UPF0210 protein
B0537_RS07935	COG0564	pseudouridine synthase activity
B0537_RS07940	COG1252	NADH dehydrogenase
B0537_RS07950	COG2707	UPF0756 membrane protein
B0537_RS07955	COG1809	phosphosulfolactate synthase activity
B0537_RS07960	COG2814	Major facilitator Superfamily
B0537_RS07970	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B0537_RS07975	COG0540	Belongs to the ATCase OTCase family
B0537_RS07980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B0537_RS07990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B0537_RS07995	COG0543	2 iron, 2 sulfur cluster binding
B0537_RS08000	COG0167	dihydroorotate dehydrogenase activity
B0537_RS08005	COG0284	orotidine-5'-phosphate decarboxylase activity
B0537_RS08015	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B0537_RS08035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B0537_RS08040	COG3344	reverse transcriptase
B0537_RS08050	COG0840	transmembrane signaling receptor activity
B0537_RS08055	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B0537_RS08060	COG0436	Aminotransferase
B0537_RS08070	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B0537_RS08075	COG1561	YicC-like family, N-terminal region
B0537_RS08080	COG2052	Domain of unknown function (DUF370)
B0537_RS08085	COG0194	GDP metabolic process
B0537_RS08090	COG1758	RNA polymerase activity
B0537_RS08095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B0537_RS08100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B0537_RS08105	COG0242	peptide deformylase activity
B0537_RS08110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B0537_RS08120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B0537_RS08120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B0537_RS08125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B0537_RS08130	COG1716	ATPase activity
B0537_RS08135	COG1716	ATPase activity
B0537_RS08140	COG0631	protein serine/threonine phosphatase activity
B0537_RS08145	COG0772	Belongs to the SEDS family
B0537_RS08150	COG0768	penicillin binding
B0537_RS08155	COG0515	serine threonine protein kinase
B0537_RS08155	COG2815	serine threonine protein kinase
B0537_RS08160	COG1162	GTPase activity
B0537_RS08165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B0537_RS08175	COG0563	adenylate kinase activity
B0537_RS08185	COG0559	Belongs to the binding-protein-dependent transport system permease family
B0537_RS08205	COG2204	response regulator
B0537_RS08235	COG3290	protein histidine kinase activity
B0537_RS08235	COG3829	transcription factor binding
B0537_RS08270	COG2414	aldehyde ferredoxin oxidoreductase
B0537_RS08285	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B0537_RS08285	COG0674	pyruvate-flavodoxin oxidoreductase activity
B0537_RS08290	COG1013	pyruvate-flavodoxin oxidoreductase activity
B0537_RS08320	COG0697	spore germination
B0537_RS08340	COG0492	ferredoxin-NADP+ reductase activity
B0537_RS08365	COG0045	succinate-CoA ligase (ADP-forming) activity
B0537_RS08370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B0537_RS08375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B0537_RS08390	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
B0537_RS08405	COG0500	methyltransferase
B0537_RS08410	COG0071	Belongs to the small heat shock protein (HSP20) family
B0537_RS08415	COG1247	-acetyltransferase
B0537_RS08425	COG1484	DNA-dependent DNA replication
B0537_RS08445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B0537_RS08455	COG1199	ATP-dependent helicase activity
B0537_RS08455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B0537_RS08460	COG1183	phosphatidylcholine synthase activity
B0537_RS08465	COG3852	Histidine kinase
B0537_RS08485	COG2217	Heavy metal translocating P-type atpase
B0537_RS08490	COG2608	mercury ion transmembrane transporter activity
B0537_RS08515	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B0537_RS08525	COG0602	queuosine metabolic process
B0537_RS08530	COG0302	gtp cyclohydrolase
B0537_RS08540	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B0537_RS08550	COG2244	polysaccharide biosynthetic process
B0537_RS08555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B0537_RS08560	COG3344	reverse transcriptase
B0537_RS08595	COG0789	Transcriptional regulator
B0537_RS08605	COG0105	UTP biosynthetic process
B0537_RS08630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B0537_RS08635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B0537_RS08640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B0537_RS08645	COG2081	HI0933 family
B0537_RS08650	COG0247	lactate metabolic process
B0537_RS08660	COG1349	DNA-binding transcription factor activity
B0537_RS08670	COG0126	phosphoglycerate kinase activity
B0537_RS08675	COG0149	triose-phosphate isomerase activity
B0537_RS08680	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B0537_RS08690	COG3344	reverse transcriptase
B0537_RS08735	COG0543	2 iron, 2 sulfur cluster binding
B0537_RS08745	COG3344	reverse transcriptase
B0537_RS08755	COG1181	Belongs to the D-alanine--D-alanine ligase family
B0537_RS08765	COG1615	UPF0182 protein
B0537_RS08795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B0537_RS08800	COG1610	YqeY-like protein
B0537_RS08810	COG2080	2 iron, 2 sulfur cluster binding
B0537_RS08810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B0537_RS08830	COG0488	(ABC) transporter
B0537_RS08855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B0537_RS08885	COG0004	ammonium transporteR
B0537_RS08930	COG0310	cobalt ion transport
B0537_RS08935	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
B0537_RS08945	COG1122	ATPase activity
B0537_RS08950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B0537_RS08960	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B0537_RS08965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B0537_RS08980	COG4120	Belongs to the binding-protein-dependent transport system permease family
B0537_RS08995	COG0367	asparagine synthase
B0537_RS09010	COG0067	glutamate synthase
B0537_RS09010	COG0069	glutamate synthase activity
B0537_RS09010	COG0070	glutamate synthase
B0537_RS09015	COG0493	'glutamate synthase
B0537_RS09065	COG0556	nucleotide-excision repair
B0537_RS09085	COG3279	Response regulator of the LytR AlgR family
B0537_RS09090	COG1966	Carbon starvation protein
B0537_RS09100	COG0701	Predicted permease
B0537_RS09110	COG0640	Transcriptional regulator
B0537_RS09125	COG0798	PFAM Bile acid sodium symporter
B0537_RS09130	COG0640	Transcriptional regulator
B0537_RS09140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B0537_RS09145	COG3426	butyrate kinase activity
B0537_RS09150	COG0280	phosphate acetyltransferase
B0537_RS09170	COG2855	membrane
B0537_RS09180	COG4585	Histidine kinase
B0537_RS09185	COG2197	response regulator
B0537_RS09195	COG2855	membrane
B0537_RS09200	COG0039	L-malate dehydrogenase activity
B0537_RS09205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B0537_RS09210	COG1053	succinate dehydrogenase
B0537_RS09215	COG2009	succinate dehydrogenase
B0537_RS09220	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B0537_RS09235	COG3829	transcription factor binding
B0537_RS09235	COG3290	protein histidine kinase activity
B0537_RS09240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B0537_RS09245	COG0789	Transcriptional regulator
B0537_RS09265	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B0537_RS09265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B0537_RS09270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B0537_RS09275	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B0537_RS09280	COG0464	growth
B0537_RS09285	COG1923	regulation of RNA biosynthetic process
B0537_RS09290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B0537_RS09295	COG2521	methyltransferase
B0537_RS09295	COG2136	Putative SAM-dependent methyltransferase
B0537_RS09300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B0537_RS09315	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B0537_RS09325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B0537_RS09330	COG2135	peptidase activity
B0537_RS09350	COG0028	Belongs to the TPP enzyme family
B0537_RS09355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B0537_RS09360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B0537_RS09365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B0537_RS09370	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B0537_RS09375	COG0463	Glycosyl transferase, family 2
B0537_RS09385	COG0850	regulation of cytokinetic process
B0537_RS09390	COG0494	nUDIX hydrolase
B0537_RS09405	COG0454	-acetyltransferase
B0537_RS09410	COG0516	GMP reductase activity
B0537_RS09410	COG0517	IMP dehydrogenase activity
B0537_RS09440	COG0436	Aminotransferase
B0537_RS09445	COG0613	PHP domain protein
B0537_RS09455	COG2359	stage V sporulation protein S
B0537_RS09460	COG1692	metallophosphoesterase
B0537_RS09470	COG1418	mRNA catabolic process
B0537_RS09475	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B0537_RS09480	COG0513	Belongs to the DEAD box helicase family
B0537_RS09485	COG1058	Belongs to the CinA family
B0537_RS09485	COG1546	Belongs to the CinA family
B0537_RS09490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B0537_RS09500	COG5002	protein histidine kinase activity
B0537_RS09505	COG0745	RESPONSE REGULATOR receiver
B0537_RS09510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B0537_RS09515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B0537_RS09520	COG1666	GTP binding
B0537_RS09525	COG0758	DNA mediated transformation
B0537_RS09540	COG1426	Protein conserved in bacteria
B0537_RS09545	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B0537_RS09550	COG1674	ftsk spoiiie
B0537_RS09570	COG0740	serine-type endopeptidase activity
B0537_RS09575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B0537_RS09580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B0537_RS09585	COG0527	aspartate kinase activity
B0537_RS09590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B0537_RS09595	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B0537_RS09600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B0537_RS09620	COG0612	Peptidase, M16
B0537_RS09625	COG0726	polysaccharide deacetylase
B0537_RS09635	COG1185	polyribonucleotide nucleotidyltransferase activity
B0537_RS09640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B0537_RS09655	COG0196	riboflavin kinase activity
B0537_RS09660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B0537_RS09665	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B0537_RS09670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B0537_RS09675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B0537_RS09685	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B0537_RS09690	COG0195	Participates in both transcription termination and antitermination
B0537_RS09695	COG0779	Required for maturation of 30S ribosomal subunits
B0537_RS09720	COG2176	DNA-directed DNA polymerase activity
B0537_RS09725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B0537_RS09730	COG0442	prolyl-tRNA aminoacylation
B0537_RS09735	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B0537_RS09740	COG0750	zinc metalloprotease
B0537_RS09745	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B0537_RS09750	COG0628	permease
B0537_RS09755	COG4589	Belongs to the CDS family
B0537_RS09775	COG0233	cytoplasmic translational termination
B0537_RS09780	COG0528	UMP kinase activity
B0537_RS09785	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B0537_RS09790	COG0052	Belongs to the universal ribosomal protein uS2 family
B0537_RS09800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B0537_RS09805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B0537_RS09810	COG4974	Belongs to the 'phage' integrase family
B0537_RS09815	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B0537_RS09820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B0537_RS09825	COG0758	DNA mediated transformation
B0537_RS09855	COG0659	secondary active sulfate transmembrane transporter activity
B0537_RS09870	COG3852	Histidine kinase
B0537_RS09875	COG2204	response regulator
B0537_RS09880	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B0537_RS09885	COG2719	SpoVR family
B0537_RS09890	COG2718	Belongs to the UPF0229 family
B0537_RS09895	COG2766	serine protein kinase
B0537_RS09910	COG2839	Protein conserved in bacteria
B0537_RS09915	COG0072	phenylalanine-tRNA ligase activity
B0537_RS09915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B0537_RS09920	COG1484	DNA-dependent DNA replication
B0537_RS09960	COG1433	Dinitrogenase iron-molybdenum cofactor
B0537_RS09960	COG0535	radical SAM domain protein
B0537_RS09965	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
B0537_RS09985	COG0347	Belongs to the P(II) protein family
B0537_RS09990	COG0347	Belongs to the P(II) protein family
B0537_RS09995	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
B0537_RS10020	COG1114	Component of the transport system for branched-chain amino acids
B0537_RS10050	COG0606	chelatase, subunit chli
B0537_RS10075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B0537_RS10090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B0537_RS10100	COG0792	nuclease activity
B0537_RS10105	COG1007	ATP synthesis coupled electron transport
B0537_RS10110	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B0537_RS10115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B0537_RS10130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B0537_RS10135	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B0537_RS10140	COG0649	NAD binding
B0537_RS10145	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B0537_RS10150	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B0537_RS10155	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B0537_RS10160	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B0537_RS10165	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B0537_RS10170	COG0681	Belongs to the peptidase S26 family
B0537_RS10175	COG0335	large ribosomal subunit rRNA binding
B0537_RS10180	COG0336	Belongs to the RNA methyltransferase TrmD family
B0537_RS10185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B0537_RS10200	COG0228	four-way junction DNA binding
B0537_RS10205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B0537_RS10210	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B0537_RS10240	COG0024	Methionine aminopeptidase
B0537_RS10285	COG0402	S-adenosylhomocysteine deaminase activity
B0537_RS10295	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B0537_RS10300	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B0537_RS10305	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B0537_RS10315	COG0552	protein localization to endoplasmic reticulum
B0537_RS10320	COG1196	nuclear chromosome segregation
B0537_RS10325	COG0571	ribonuclease III activity
B0537_RS10330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B0537_RS10335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B0537_RS10340	COG1028	Short-chain dehydrogenase reductase Sdr
B0537_RS10345	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B0537_RS10350	COG2070	2-Nitropropane dioxygenase
B0537_RS10355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B0537_RS10360	COG0416	fatty acid biosynthetic process
B0537_RS10365	COG2030	dehydratase
B0537_RS10370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B0537_RS10380	COG3314	Sporulation integral membrane protein YlbJ
B0537_RS10390	COG0857	belongs to the CobB CobQ family
B0537_RS10405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B0537_RS10410	COG0742	ribosomal rna small subunit methyltransferase
B0537_RS10415	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B0537_RS10425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B0537_RS10430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B0537_RS10435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B0537_RS10440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B0537_RS10440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B0537_RS10465	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B0537_RS10470	COG4869	propanediol catabolic process
B0537_RS10490	COG3328	transposase activity
B0537_RS10500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B0537_RS10510	COG3773	Cell wall hydrolase
B0537_RS10515	COG3935	DnaD domain protein
B0537_RS10520	COG0581	inorganic phosphate transmembrane transporter activity
B0537_RS10525	COG0573	inorganic phosphate transmembrane transporter activity
B0537_RS10530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B0537_RS10545	COG2197	response regulator
B0537_RS10560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B0537_RS10565	COG0154	amidase activity
B0537_RS10570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B0537_RS10575	COG0840	transmembrane signaling receptor activity
B0537_RS10575	COG3290	protein histidine kinase activity
B0537_RS10580	COG0840	transmembrane signaling receptor activity
B0537_RS10600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B0537_RS10655	COG1509	lysine 2,3-aminomutase activity
B0537_RS10670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B0537_RS10675	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B0537_RS10680	COG1027	Aspartate ammonia-lyase
B0537_RS10690	COG0835	chemotaxis
B0537_RS10695	COG0393	Putative heavy-metal-binding
B0537_RS10705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B0537_RS10710	COG1522	sequence-specific DNA binding
B0537_RS10715	COG1522	sequence-specific DNA binding
B0537_RS10720	COG0535	radical SAM domain protein
B0537_RS10725	COG0113	porphobilinogen synthase activity
B0537_RS10730	COG0535	radical SAM domain protein
B0537_RS10740	COG0181	hydroxymethylbilane synthase activity
B0537_RS10745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B0537_RS10750	COG1648	precorrin-2 dehydrogenase activity
B0537_RS10750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B0537_RS10755	COG0142	geranyltranstransferase activity
B0537_RS10825	COG3344	reverse transcriptase
B0537_RS10840	COG2267	carboxylic ester hydrolase activity
B0537_RS10855	COG5278	phosphoserine phosphatase activity
B0537_RS10855	COG0840	transmembrane signaling receptor activity
B0537_RS10890	COG0589	response to stress
B0537_RS10900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B0537_RS10905	COG1079	Belongs to the binding-protein-dependent transport system permease family
B0537_RS10910	COG4603	Belongs to the binding-protein-dependent transport system permease family
B0537_RS10925	COG1278	Cold shock
B0537_RS10935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B0537_RS10955	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B0537_RS10965	COG1921	L-seryl-tRNASec selenium transferase activity
B0537_RS10970	COG2186	Transcriptional regulator
B0537_RS10975	COG1620	l-lactate permease
B0537_RS10990	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B0537_RS10995	COG1592	Rubrerythrin
B0537_RS11000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B0537_RS11020	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B0537_RS11030	COG0438	transferase activity, transferring glycosyl groups
B0537_RS11055	COG1410	methionine synthase
B0537_RS11055	COG0646	methionine synthase
B0537_RS11065	COG2081	HI0933 family
B0537_RS11070	COG0012	GTP binding
B0537_RS11075	COG0733	neurotransmitter:sodium symporter activity
B0537_RS11080	COG3033	Beta-eliminating lyase
B0537_RS11090	COG0531	amino acid
B0537_RS11095	COG3706	GGDEF domain
B0537_RS11100	COG1592	Rubrerythrin
B0537_RS11120	COG3290	protein histidine kinase activity
B0537_RS11120	COG0840	transmembrane signaling receptor activity
B0537_RS11125	COG0024	Methionine aminopeptidase
B0537_RS11130	COG2315	Protein conserved in bacteria
B0537_RS11135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B0537_RS11150	COG0494	nUDIX hydrolase
B0537_RS11165	COG1028	Short-chain dehydrogenase reductase Sdr
B0537_RS11180	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B0537_RS11190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B0537_RS11215	COG3328	transposase activity
B0537_RS11225	COG0662	Cupin 2, conserved barrel domain protein
B0537_RS11235	COG0778	Nitroreductase
B0537_RS11240	COG0655	NAD(P)H dehydrogenase (quinone) activity
B0537_RS11270	COG4974	Belongs to the 'phage' integrase family
B0537_RS11275	COG0582	viral genome integration into host DNA
B0537_RS11280	COG4974	Belongs to the 'phage' integrase family
B0537_RS11310	COG0640	Transcriptional regulator
B0537_RS11315	COG0640	Transcriptional regulator
B0537_RS11325	COG0640	Transcriptional regulator
B0537_RS11330	COG0798	PFAM Bile acid sodium symporter
B0537_RS11365	COG3344	reverse transcriptase
B0537_RS11385	COG0840	transmembrane signaling receptor activity
B0537_RS11385	COG5278	phosphoserine phosphatase activity
B0537_RS11390	COG2217	Heavy metal translocating P-type atpase
B0537_RS11400	COG5002	protein histidine kinase activity
B0537_RS11405	COG0745	RESPONSE REGULATOR receiver
B0537_RS11475	COG0390	transport system, permease component
B0537_RS11480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B0537_RS11500	COG3464	Transposase
B0537_RS11530	COG5632	N-Acetylmuramoyl-L-alanine amidase
B0537_RS11530	COG3409	Peptidoglycan-binding domain 1 protein
B0537_RS11625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B0537_RS11640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B0537_RS11650	COG0315	cyclic pyranopterin monophosphate synthase activity
B0537_RS11655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B0537_RS11660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B0537_RS11685	COG2204	response regulator
B0537_RS11700	COG1454	alcohol dehydrogenase
B0537_RS11705	COG0737	Belongs to the 5'-nucleotidase family
B0537_RS11710	COG3706	GGDEF domain
B0537_RS11720	COG0860	N-Acetylmuramoyl-L-alanine amidase
B0537_RS11735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B0537_RS11740	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B0537_RS11760	COG0582	viral genome integration into host DNA
B0537_RS11835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B0537_RS11865	COG1321	iron dependent repressor
B0537_RS11885	COG2252	PERMEase
B0537_RS11900	COG0598	Magnesium transport protein CorA
B0537_RS11905	COG4447	cellulose binding
B0537_RS11910	COG1191	sigma factor activity
B0537_RS11915	COG0159	tryptophan synthase activity
B0537_RS11920	COG0133	tryptophan synthase activity
B0537_RS11925	COG0135	phosphoribosylanthranilate isomerase activity
B0537_RS11930	COG0134	indole-3-glycerol-phosphate synthase activity
B0537_RS11935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B0537_RS11940	COG0512	Glutamine amidotransferase of anthranilate synthase
B0537_RS11940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B0537_RS11970	COG0205	6-phosphofructokinase activity
B0537_RS11975	COG0825	malonyl-CoA metabolic process
B0537_RS11980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B0537_RS12010	COG0791	NLP P60 protein
B0537_RS12020	COG0438	transferase activity, transferring glycosyl groups
B0537_RS12025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B0537_RS12030	COG1543	Belongs to the glycosyl hydrolase 57 family
B0537_RS12045	COG2431	L-lysine efflux transmembrane transporter activity
B0537_RS12055	COG1832	CoA-binding protein
B0537_RS12060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B0537_RS12065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B0537_RS12070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B0537_RS12075	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B0537_RS12090	COG0473	3-isopropylmalate dehydrogenase activity
B0537_RS12095	COG0066	3-isopropylmalate dehydratase activity
B0537_RS12100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B0537_RS12105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B0537_RS12115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B0537_RS12120	COG0154	amidase activity
B0537_RS12125	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B0537_RS12130	COG0251	oxidation-reduction process
B0537_RS12135	COG3266	domain, Protein
B0537_RS12135	COG2911	Protein conserved in bacteria
B0537_RS12135	COG1361	Conserved repeat domain
B0537_RS12145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B0537_RS12160	COG0140	phosphoribosyl-ATP diphosphatase activity
B0537_RS12160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B0537_RS12165	COG0107	imidazoleglycerol-phosphate synthase activity
B0537_RS12170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B0537_RS12175	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B0537_RS12180	COG0131	Imidazoleglycerol-phosphate dehydratase
B0537_RS12185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B0537_RS12195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B0537_RS12200	COG0124	histidyl-tRNA synthetase
B0537_RS12205	COG4496	protein, YerC YecD
B0537_RS12215	COG0138	bifunctional purine biosynthesis protein purh
B0537_RS12220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B0537_RS12225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B0537_RS12230	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B0537_RS12235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B0537_RS12240	COG0047	phosphoribosylformylglycinamidine synthase activity
B0537_RS12245	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B0537_RS12250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B0537_RS12255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B0537_RS12260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B0537_RS12265	COG2252	PERMEase
B0537_RS12270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B0537_RS12280	COG0519	Catalyzes the synthesis of GMP from XMP
B0537_RS12280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B0537_RS12285	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B0537_RS12285	COG0037	tRNA processing
B0537_RS12295	COG1694	Mazg nucleotide pyrophosphohydrolase
B0537_RS12305	COG1776	CheC inhibitor of MCP methylation
B0537_RS12305	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B0537_RS12310	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B0537_RS12315	COG2201	protein-glutamate methylesterase activity
B0537_RS12320	COG1776	CheC inhibitor of MCP methylation
B0537_RS12325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B0537_RS12330	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B0537_RS12340	COG4786	Flagellar basal body rod
B0537_RS12345	COG1191	sigma factor activity
B0537_RS12360	COG1419	protein localization to endoplasmic reticulum
B0537_RS12365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B0537_RS12370	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B0537_RS12375	COG1684	flagellar biosynthetic protein fliR
B0537_RS12385	COG1338	Plays a role in the flagellum-specific transport system
B0537_RS12405	COG4786	Flagellar basal body rod
B0537_RS12415	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B0537_RS12420	COG3144	bacterial-type flagellum assembly
B0537_RS12430	COG1157	protein secretion by the type III secretion system
B0537_RS12440	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B0537_RS12445	COG1766	The M ring may be actively involved in energy transduction
B0537_RS12450	COG1677	Flagellar hook-basal body complex protein FliE
B0537_RS12460	COG1815	bacterial-type flagellum-dependent cell motility
B0537_RS12490	COG1516	flagellar protein fliS
B0537_RS12495	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B0537_RS12500	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B0537_RS12505	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B0537_RS12510	COG0133	tryptophan synthase activity
B0537_RS12520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B0537_RS12540	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B0537_RS12560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B0537_RS12580	COG2201	protein-glutamate methylesterase activity
B0537_RS12585	COG0643	Histidine kinase
B0537_RS12585	COG2198	Histidine kinase
B0537_RS12600	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B0537_RS12605	COG2045	Belongs to the ComB family
B0537_RS12625	COG2364	Membrane
B0537_RS12630	COG3706	GGDEF domain
B0537_RS12635	COG4608	Belongs to the ABC transporter superfamily
B0537_RS12640	COG0444	Belongs to the ABC transporter superfamily
B0537_RS12645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B0537_RS12650	COG0601	transmembrane transport
B0537_RS12655	COG0747	negative chemotaxis
B0537_RS12675	COG1773	rubredoxin
B0537_RS12675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B0537_RS12685	COG0328	RNA-DNA hybrid ribonuclease activity
B0537_RS12690	COG1164	Oligoendopeptidase f
B0537_RS12700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B0537_RS12705	COG2384	SAM-dependent methyltransferase
B0537_RS12710	COG0840	transmembrane signaling receptor activity
B0537_RS12740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B0537_RS12745	COG0358	DNA primase activity
B0537_RS12750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B0537_RS12760	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B0537_RS12775	COG5002	protein histidine kinase activity
B0537_RS12780	COG0745	RESPONSE REGULATOR receiver
B0537_RS12795	COG0463	Glycosyl transferase, family 2
B0537_RS12800	COG0463	Glycosyl transferase, family 2
B0537_RS12805	COG0457	Tetratricopeptide repeat
B0537_RS12805	COG0463	Glycosyl transferase, family 2
B0537_RS12825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B0537_RS12825	COG0574	Belongs to the PEP-utilizing enzyme family
B0537_RS12830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B0537_RS12835	COG0517	IMP dehydrogenase activity
B0537_RS12840	COG0751	glycine-tRNA ligase activity
B0537_RS12845	COG0752	glycyl-tRNA synthetase alpha subunit
B0537_RS12855	COG1381	Involved in DNA repair and RecF pathway recombination
B0537_RS12860	COG2239	Acts as a magnesium transporter
B0537_RS12865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B0537_RS12875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B0537_RS12880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B0537_RS12885	COG1480	7TM receptor with intracellular HD hydrolase
B0537_RS12890	COG1702	phosphate starvation-inducible protein PhoH
B0537_RS12915	COG1030	water channel activity
B0537_RS12920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B0537_RS12925	COG0537	adenosine 5'-monophosphoramidase activity
B0537_RS12930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B0537_RS12935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B0537_RS12940	COG2264	protein methyltransferase activity
B0537_RS12945	COG0484	heat shock protein binding
B0537_RS12950	COG0443	Heat shock 70 kDa protein
B0537_RS12960	COG0459	protein refolding
B0537_RS12965	COG1420	regulation of RNA biosynthetic process
B0537_RS12970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B0537_RS12980	COG0481	GTPase activity
B0537_RS13000	COG0268	Binds directly to 16S ribosomal RNA
B0537_RS13010	COG0011	TIGRFAM Protein of
B0537_RS13025	COG2333	competence protein COMEC
B0537_RS13025	COG0658	competence protein
B0537_RS13030	COG0741	lytic transglycosylase activity
B0537_RS13035	COG1555	photosystem II stabilization
B0537_RS13040	COG2323	membrane
B0537_RS13045	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B0537_RS13050	COG0495	leucyl-tRNA aminoacylation
B0537_RS13055	COG0318	PFAM AMP-dependent synthetase and ligase
B0537_RS13060	COG0799	negative regulation of ribosome biogenesis
B0537_RS13065	COG1713	HD superfamily hydrolase involved in NAD metabolism
B0537_RS13070	COG0724	RNA recognition motif
B0537_RS13075	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B0537_RS13090	COG1879	ABC-type sugar transport system periplasmic component
B0537_RS13095	COG1172	Belongs to the binding-protein-dependent transport system permease family
B0537_RS13100	COG1129	ABC transporter
B0537_RS13105	COG1869	D-ribose catabolic process
B0537_RS13110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B0537_RS13115	COG1609	Transcriptional regulator
B0537_RS13120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B0537_RS13145	COG0840	transmembrane signaling receptor activity
B0537_RS13160	COG1489	DNA binding
B0537_RS13165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B0537_RS13175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B0537_RS13180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B0537_RS13185	COG1530	ribonuclease E activity
B0537_RS13200	COG1994	Peptidase M50
B0537_RS13210	COG0772	Belongs to the SEDS family
B0537_RS13215	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B0537_RS13220	COG2894	cell division
B0537_RS13225	COG0850	regulation of cytokinetic process
B0537_RS13230	COG0768	penicillin binding
B0537_RS13240	COG1792	Involved in formation and maintenance of cell shape
B0537_RS13245	COG1077	Cell shape determining protein MreB Mrl
B0537_RS13250	COG2003	Belongs to the UPF0758 family
B0537_RS13255	COG0424	maF-like protein
B0537_RS13265	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B0537_RS13270	COG0285	dihydrofolate synthase activity
B0537_RS13275	COG1598	PFAM Uncharacterised protein family UPF0150
B0537_RS13280	COG0525	valine-tRNA ligase activity
B0537_RS13300	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B0537_RS13305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B0537_RS13310	COG1067	ATP-dependent peptidase activity
B0537_RS13310	COG0470	DNA polymerase III
B0537_RS13320	COG0740	serine-type endopeptidase activity
B0537_RS13325	COG0544	peptidyl-prolyl cis-trans isomerase activity
B0537_RS13350	COG1122	ATPase activity
B0537_RS13365	COG0310	cobalt ion transport
B0537_RS13380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B0537_RS13390	COG0419	ATPase involved in DNA repair
B0537_RS13395	COG0420	3'-5' exonuclease activity
B0537_RS13415	COG0658	competence protein
B0537_RS13415	COG2333	competence protein COMEC
B0537_RS13425	COG0860	N-Acetylmuramoyl-L-alanine amidase
B0537_RS13460	COG5002	protein histidine kinase activity
B0537_RS13465	COG3328	transposase activity
B0537_RS13475	COG0501	Belongs to the peptidase M48B family
B0537_RS13480	COG4326	sporulation control protein
B0537_RS13485	COG0789	Transcriptional regulator
B0537_RS13500	COG5002	protein histidine kinase activity
B0537_RS13500	COG5001	Diguanylate cyclase
B0537_RS13505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B0537_RS13520	COG4191	Histidine kinase
B0537_RS13525	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B0537_RS13535	COG0072	phenylalanine-tRNA ligase activity
B0537_RS13535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B0537_RS13550	COG1360	Flagellar Motor Protein
B0537_RS13555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B0537_RS13565	COG0840	transmembrane signaling receptor activity
B0537_RS13595	COG1131	(ABC) transporter
B0537_RS13600	COG1725	Transcriptional regulator
B0537_RS13620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B0537_RS13625	COG2011	ABC-type metal ion transport system permease component
B0537_RS13630	COG1464	Belongs to the NlpA lipoprotein family
B0537_RS13635	COG1191	sigma factor activity
B0537_RS13640	COG1392	Phosphate transport regulator
B0537_RS13645	COG0306	phosphate transporter
B0537_RS13680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B0537_RS13685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B0537_RS13695	COG1695	Transcriptional regulator
B0537_RS13715	COG3852	Histidine kinase
B0537_RS13735	COG2247	cell wall binding repeat
B0537_RS13735	COG0860	N-Acetylmuramoyl-L-alanine amidase
B0537_RS13750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B0537_RS13755	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B0537_RS13765	COG1234	tRNA 3'-trailer cleavage
B0537_RS13780	COG3799	methylaspartate ammonia-lyase activity
B0537_RS13785	COG4865	methylaspartate mutase activity
B0537_RS13795	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B0537_RS13800	COG0860	N-Acetylmuramoyl-L-alanine amidase
B0537_RS13800	COG2247	cell wall binding repeat
B0537_RS13805	COG1376	ErfK ybiS ycfS ynhG family protein
B0537_RS13820	COG2373	Large extracellular alpha-helical protein
B0537_RS13830	COG2340	Cysteine-rich secretory protein family
B0537_RS13865	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B0537_RS13870	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B0537_RS13875	COG1492	cobalamin metabolic process
B0537_RS13920	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
B0537_RS13930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B0537_RS13940	COG1739	Uncharacterized protein family UPF0029
B0537_RS13945	COG4822	anaerobic cobalamin biosynthetic process
B0537_RS13955	COG5401	PFAM Sporulation and spore germination
B0537_RS13970	COG1388	LysM domain
B0537_RS13970	COG0791	NLP P60 protein
B0537_RS13980	COG0733	neurotransmitter:sodium symporter activity
B0537_RS13995	COG1283	sodium-dependent phosphate transmembrane transporter activity
B0537_RS14005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B0537_RS14020	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B0537_RS14030	COG3942	CHAP domain
B0537_RS14030	COG1388	LysM domain
B0537_RS14080	COG0569	domain protein
B0537_RS14085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B0537_RS14090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B0537_RS14105	COG0425	Belongs to the sulfur carrier protein TusA family
B0537_RS14120	COG1331	Highly conserved protein containing a thioredoxin domain
B0537_RS14135	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B0537_RS14140	COG0840	transmembrane signaling receptor activity
B0537_RS14165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B0537_RS14180	COG0686	Belongs to the AlaDH PNT family
B0537_RS14220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B0537_RS14220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B0537_RS14225	COG0736	holo-[acyl-carrier-protein] synthase activity
B0537_RS14235	COG3275	phosphorelay sensor kinase activity
B0537_RS14240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B0537_RS14260	COG0459	protein refolding
B0537_RS14270	COG0521	Mo-molybdopterin cofactor biosynthetic process
B0537_RS14275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B0537_RS14290	COG1910	domain protein
B0537_RS14295	COG0303	'Molybdopterin
B0537_RS14305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B0537_RS14315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B0537_RS14325	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
B0537_RS14330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B0537_RS14335	COG0456	acetyltransferase
B0537_RS14340	COG1214	PFAM Peptidase M22, glycoprotease
B0537_RS14345	COG0802	atpase or kinase
B0537_RS14355	COG2204	response regulator
B0537_RS14365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B0537_RS14370	COG2337	Toxic component of a toxin-antitoxin (TA) module
B0537_RS14375	COG0864	Transcriptional regulator
B0537_RS14380	COG0440	acetolactate synthase activity
B0537_RS14410	COG0166	Belongs to the GPI family
B0537_RS14415	COG0840	transmembrane signaling receptor activity
B0537_RS14445	COG3546	catalase activity
B0537_RS14455	COG0725	ABC transporter, periplasmic molybdate-binding protein
B0537_RS14475	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B0537_RS14500	COG1203	CRISPR-associated helicase, Cas3
B0537_RS14525	COG0569	domain protein
B0537_RS14645	COG0116	Belongs to the methyltransferase superfamily
B0537_RS14650	COG1151	hydroxylamine reductase activity
B0537_RS14710	COG1309	transcriptional regulator
B0537_RS14730	COG1686	Belongs to the peptidase S11 family
B0537_RS14745	COG1309	transcriptional regulator
B0537_RS14770	COG4948	Mandelate Racemase Muconate Lactonizing
B0537_RS14780	COG1473	amidohydrolase
B0537_RS14790	COG1592	Rubrerythrin
B0537_RS14795	COG0840	transmembrane signaling receptor activity
B0537_RS14800	COG0318	PFAM AMP-dependent synthetase and ligase
B0537_RS14805	COG1959	2 iron, 2 sulfur cluster binding
B0537_RS14810	COG2205	protein histidine kinase activity
B0537_RS14820	COG1802	Transcriptional regulator
B0537_RS14840	COG4120	Belongs to the binding-protein-dependent transport system permease family
B0537_RS14845	COG1122	ATPase activity
B0537_RS14915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B0537_RS15030	COG1396	sequence-specific DNA binding
B0537_RS15060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B0537_RS15075	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B0537_RS15080	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B0537_RS15085	COG0148	phosphopyruvate hydratase activity
B0537_RS15090	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B0537_RS15095	COG0149	triose-phosphate isomerase activity
B0537_RS15100	COG0126	phosphoglycerate kinase activity
B0537_RS15110	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B0537_RS15120	COG1481	regulation of sporulation
B0537_RS15130	COG0726	polysaccharide deacetylase
B0537_RS15135	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B0537_RS15140	COG1660	Displays ATPase and GTPase activities
B0537_RS15150	COG0561	phosphatase activity
B0537_RS15155	COG0322	excinuclease ABC activity
B0537_RS15165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B0537_RS15170	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B0537_RS15185	COG2852	Protein conserved in bacteria
B0537_RS15190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B0537_RS15200	COG0556	nucleotide-excision repair
B0537_RS15210	COG1573	uracil-dna glycosylase
B0537_RS15220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B0537_RS15225	COG3409	Peptidoglycan-binding domain 1 protein
B0537_RS15225	COG0793	Belongs to the peptidase S41A family
B0537_RS15230	COG0739	heme binding
B0537_RS15235	COG2177	Part of the ABC transporter FtsEX involved in
B0537_RS15240	COG2884	Cell division ATP-binding protein ftsE
B0537_RS15250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B0537_RS15255	COG3959	Transketolase, thiamine diphosphate binding domain
B0537_RS15260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B0537_RS15265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B0537_RS15270	COG0653	protein targeting
B0537_RS15280	COG1278	Cold shock
B0537_RS15285	COG1040	competence protein
B0537_RS15310	COG3706	GGDEF domain
B0537_RS15315	COG0463	Glycosyl transferase, family 2
B0537_RS15320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B0537_RS15325	COG1873	PFAM PRC-barrel domain
B0537_RS15330	COG0728	peptidoglycan biosynthetic process
B0537_RS15345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B0537_RS15350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B0537_RS15355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B0537_RS15360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B0537_RS15365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B0537_RS15405	COG0445	tRNA wobble uridine modification
B0537_RS15410	COG1316	TRANSCRIPTIONal
B0537_RS15460	COG0367	asparagine synthase
B0537_RS15500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B0537_RS15535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B0537_RS15575	COG1077	Cell shape determining protein MreB Mrl
B0537_RS15580	COG1609	Transcriptional regulator
B0537_RS15590	COG2385	sporulation resulting in formation of a cellular spore
B0537_RS15595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B0537_RS15600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B0537_RS15605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B0537_RS15610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B0537_RS15615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B0537_RS15620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B0537_RS15625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B0537_RS15630	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B0537_RS15635	COG0356	it plays a direct role in the translocation of protons across the membrane
B0537_RS15650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B0537_RS15660	COG0590	tRNA wobble adenosine to inosine editing
B0537_RS15665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B0537_RS15675	COG1971	Probably functions as a manganese efflux pump
B0537_RS15680	COG0009	L-threonylcarbamoyladenylate synthase
B0537_RS15690	COG1876	peptidase activity
B0537_RS15695	COG2890	protein-(glutamine-N5) methyltransferase activity
B0537_RS15700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B0537_RS15705	COG0254	rRNA binding
B0537_RS15720	COG0739	heme binding
B0537_RS15720	COG1196	nuclear chromosome segregation
B0537_RS15720	COG0741	lytic transglycosylase activity
B0537_RS15725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B0537_RS15735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B0537_RS15750	COG2204	response regulator
B0537_RS15760	COG0616	signal peptide processing
B0537_RS15765	COG0504	CTP synthase activity
B0537_RS15775	COG0018	arginyl-trna synthetase
B0537_RS15790	COG2221	Nitrite and sulphite reductase 4Fe-4S
B0537_RS15795	COG2221	Nitrite and sulphite reductase 4Fe-4S
B0537_RS15815	COG4145	pantothenate transmembrane transporter activity
B0537_RS15820	COG0436	Aminotransferase
B0537_RS15825	COG1522	sequence-specific DNA binding
B0537_RS15830	COG2959	enzyme of heme biosynthesis
B0537_RS15840	COG1797	cobyrinic acid a,c-diamide synthase activity
B0537_RS15845	COG2920	part of a sulfur-relay system
B0537_RS15850	COG0247	lactate metabolic process
B0537_RS15870	COG0514	ATP-dependent DNA helicase (RecQ)