locus-tag	class	description
DESCA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DESCA_RS00010	COG0592	DNA-directed DNA polymerase activity
DESCA_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DESCA_RS00030	COG0187	DNA topoisomerase II activity
DESCA_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DESCA_RS00070	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DESCA_RS00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DESCA_RS00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DESCA_RS00115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DESCA_RS00120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DESCA_RS00125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DESCA_RS00155	COG0590	tRNA wobble adenosine to inosine editing
DESCA_RS00180	COG0778	Nitroreductase
DESCA_RS00195	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DESCA_RS00200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DESCA_RS00205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DESCA_RS00210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DESCA_RS00255	COG1982	Orn Lys Arg decarboxylase major
DESCA_RS00260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DESCA_RS00265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DESCA_RS00270	COG1774	PSP1 C-terminal conserved region
DESCA_RS00280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DESCA_RS00285	COG2002	toxin-antitoxin pair type II binding
DESCA_RS00290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DESCA_RS00290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DESCA_RS00295	COG0084	hydrolase, TatD family'
DESCA_RS00305	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DESCA_RS00315	COG3584	3D domain protein
DESCA_RS00315	COG3583	domain protein
DESCA_RS00320	COG3583	domain protein
DESCA_RS00320	COG3584	3D domain protein
DESCA_RS00325	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DESCA_RS00330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DESCA_RS00335	COG0156	8-amino-7-oxononanoate synthase activity
DESCA_RS00340	COG2267	carboxylic ester hydrolase activity
DESCA_RS00345	COG4106	trans-aconitate 2-methyltransferase activity
DESCA_RS00355	COG0693	protein deglycase activity
DESCA_RS00365	COG2022	thiamine diphosphate biosynthetic process
DESCA_RS00365	COG2104	thiamine diphosphate biosynthetic process
DESCA_RS00370	COG2022	thiamine diphosphate biosynthetic process
DESCA_RS00375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DESCA_RS00385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DESCA_RS00415	COG2340	Cysteine-rich secretory protein family
DESCA_RS00420	COG1388	LysM domain
DESCA_RS00435	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DESCA_RS00470	COG1376	ErfK ybiS ycfS ynhG family protein
DESCA_RS00475	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DESCA_RS00480	COG1802	Transcriptional regulator
DESCA_RS00490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DESCA_RS00495	COG2088	sporulation resulting in formation of a cellular spore
DESCA_RS00500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DESCA_RS00505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DESCA_RS00540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DESCA_RS00545	COG0193	aminoacyl-tRNA hydrolase activity
DESCA_RS00555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DESCA_RS00560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DESCA_RS00565	COG2002	toxin-antitoxin pair type II binding
DESCA_RS00570	COG3956	TIGRFAM MazG family protein
DESCA_RS00575	COG0776	regulation of translation
DESCA_RS00580	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DESCA_RS00585	COG2385	sporulation resulting in formation of a cellular spore
DESCA_RS00610	COG1098	S1 RNA binding domain
DESCA_RS00615	COG0248	Ppx GppA phosphatase
DESCA_RS00615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DESCA_RS00620	COG2208	phosphoserine phosphatase activity
DESCA_RS00625	COG0037	tRNA processing
DESCA_RS00630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESCA_RS00650	COG0105	UTP biosynthetic process
DESCA_RS00665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DESCA_RS00670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DESCA_RS00675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DESCA_RS00685	COG0247	lactate metabolic process
DESCA_RS00695	COG1349	DNA-binding transcription factor activity
DESCA_RS00705	COG0126	phosphoglycerate kinase activity
DESCA_RS00710	COG0149	triose-phosphate isomerase activity
DESCA_RS00715	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DESCA_RS00720	COG0148	phosphopyruvate hydratase activity
DESCA_RS00745	COG0543	2 iron, 2 sulfur cluster binding
DESCA_RS00775	COG0543	2 iron, 2 sulfur cluster binding
DESCA_RS00805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DESCA_RS00810	COG0778	Nitroreductase
DESCA_RS00815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DESCA_RS00820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DESCA_RS00825	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DESCA_RS00830	COG0617	tRNA 3'-terminal CCA addition
DESCA_RS00840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DESCA_RS00845	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DESCA_RS00850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DESCA_RS00855	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DESCA_RS00860	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DESCA_RS00885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DESCA_RS00905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DESCA_RS00910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DESCA_RS00915	COG5322	oxidoreductase activity
DESCA_RS00915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DESCA_RS00920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DESCA_RS00925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DESCA_RS00975	COG0542	response to heat
DESCA_RS00985	COG0556	nucleotide-excision repair
DESCA_RS00990	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DESCA_RS00995	COG0542	response to heat
DESCA_RS01000	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DESCA_RS01005	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DESCA_RS01015	COG1329	Transcriptional regulator
DESCA_RS01020	COG4956	integral membrane protein (PIN domain superfamily)
DESCA_RS01025	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DESCA_RS01030	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DESCA_RS01035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DESCA_RS01045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DESCA_RS01050	COG1045	serine acetyltransferase
DESCA_RS01055	COG0215	cysteine-tRNA ligase activity
DESCA_RS01060	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DESCA_RS01065	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DESCA_RS01075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DESCA_RS01080	COG3688	RNA-binding protein containing a PIN domain
DESCA_RS01115	COG3344	reverse transcriptase
DESCA_RS01120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DESCA_RS01130	COG0250	Participates in transcription elongation, termination and antitermination
DESCA_RS01135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DESCA_RS01140	COG0081	regulation of translation
DESCA_RS01145	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DESCA_RS01150	COG0222	ribosome binding
DESCA_RS01155	COG0085	RNA polymerase activity
DESCA_RS01160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DESCA_RS01165	COG1358	cellular component organization or biogenesis
DESCA_RS01170	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DESCA_RS01175	COG0049	tRNA binding
DESCA_RS01180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DESCA_RS01185	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DESCA_RS01190	COG0051	transcription antitermination factor activity, RNA binding
DESCA_RS01195	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DESCA_RS01200	COG0088	Forms part of the polypeptide exit tunnel
DESCA_RS01205	COG0089	rRNA binding
DESCA_RS01210	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DESCA_RS01215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DESCA_RS01220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DESCA_RS01225	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DESCA_RS01230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DESCA_RS01235	COG0255	Belongs to the universal ribosomal protein uL29 family
DESCA_RS01240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DESCA_RS01245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DESCA_RS01250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DESCA_RS01255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DESCA_RS01260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DESCA_RS01265	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DESCA_RS01270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DESCA_RS01275	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DESCA_RS01280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DESCA_RS01285	COG1841	ribosomal large subunit assembly
DESCA_RS01290	COG0200	Binds to the 23S rRNA
DESCA_RS01295	COG0201	protein transport
DESCA_RS01310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DESCA_RS01315	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DESCA_RS01320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DESCA_RS01325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DESCA_RS01330	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DESCA_RS01335	COG0202	RNA polymerase activity
DESCA_RS01340	COG0203	ribosomal protein L17
DESCA_RS01345	COG1122	ATPase activity
DESCA_RS01355	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DESCA_RS01360	COG0101	tRNA pseudouridine synthase activity
DESCA_RS01365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DESCA_RS01370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DESCA_RS01375	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESCA_RS01380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DESCA_RS01400	COG3885	ferrous iron binding
DESCA_RS01400	COG2078	PFAM AMMECR1 domain protein
DESCA_RS01410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DESCA_RS01415	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DESCA_RS01420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DESCA_RS01425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DESCA_RS01430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DESCA_RS01435	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DESCA_RS01440	COG0137	argininosuccinate synthase activity
DESCA_RS01445	COG0165	Argininosuccinate lyase
DESCA_RS01470	COG0129	dihydroxy-acid dehydratase activity
DESCA_RS01475	COG0028	Belongs to the TPP enzyme family
DESCA_RS01480	COG0440	acetolactate synthase activity
DESCA_RS01485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DESCA_RS01490	COG0028	Belongs to the TPP enzyme family
DESCA_RS01495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESCA_RS01500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DESCA_RS01505	COG0066	3-isopropylmalate dehydratase activity
DESCA_RS01510	COG0473	3-isopropylmalate dehydrogenase activity
DESCA_RS01515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESCA_RS01520	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DESCA_RS01530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DESCA_RS01535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DESCA_RS01680	COG1733	regulation of RNA biosynthetic process
DESCA_RS01695	COG1785	Belongs to the alkaline phosphatase family
DESCA_RS01705	COG0822	iron-sulfur transferase activity
DESCA_RS01715	COG1388	LysM domain
DESCA_RS01715	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESCA_RS01740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESCA_RS01750	COG0745	RESPONSE REGULATOR receiver
DESCA_RS01755	COG5002	protein histidine kinase activity
DESCA_RS01770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DESCA_RS01775	COG0589	response to stress
DESCA_RS01790	COG0671	phosphoesterase, PA-phosphatase related
DESCA_RS01805	COG1122	ATPase activity
DESCA_RS01815	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
DESCA_RS01820	COG0310	cobalt ion transport
DESCA_RS01825	COG0583	DNA-binding transcription factor activity
DESCA_RS01835	COG1785	Belongs to the alkaline phosphatase family
DESCA_RS01845	COG0651	ATP synthesis coupled electron transport
DESCA_RS01850	COG0650	Formate hydrogenlyase subunit 4
DESCA_RS01855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESCA_RS01865	COG0649	NAD binding
DESCA_RS01865	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESCA_RS01885	COG1151	hydroxylamine reductase activity
DESCA_RS01895	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DESCA_RS01900	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DESCA_RS01905	COG0298	carbon dioxide binding
DESCA_RS01910	COG0409	Hydrogenase expression formation protein
DESCA_RS01920	COG5002	protein histidine kinase activity
DESCA_RS01925	COG0745	RESPONSE REGULATOR receiver
DESCA_RS01930	COG0671	phosphoesterase, PA-phosphatase related
DESCA_RS01940	COG0586	Pfam SNARE associated Golgi protein
DESCA_RS01945	COG1803	Methylglyoxal synthase
DESCA_RS01950	COG0704	Plays a role in the regulation of phosphate uptake
DESCA_RS01955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DESCA_RS01960	COG0581	inorganic phosphate transmembrane transporter activity
DESCA_RS01965	COG0573	inorganic phosphate transmembrane transporter activity
DESCA_RS01985	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DESCA_RS02000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DESCA_RS02005	COG0644	oxidoreductase
DESCA_RS02035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DESCA_RS02050	COG0517	IMP dehydrogenase activity
DESCA_RS02050	COG0516	GMP reductase activity
DESCA_RS02060	COG0745	RESPONSE REGULATOR receiver
DESCA_RS02065	COG2205	protein histidine kinase activity
DESCA_RS02065	COG2770	Histidine kinase
DESCA_RS02080	COG2217	Heavy metal translocating P-type atpase
DESCA_RS02085	COG1937	Protein conserved in bacteria
DESCA_RS02090	COG0318	PFAM AMP-dependent synthetase and ligase
DESCA_RS02095	COG1132	(ABC) transporter
DESCA_RS02105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DESCA_RS02110	COG0321	lipoyl(octanoyl) transferase activity
DESCA_RS02115	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DESCA_RS02150	COG0725	ABC transporter, periplasmic molybdate-binding protein
DESCA_RS02160	COG1151	hydroxylamine reductase activity
DESCA_RS02190	COG1686	Belongs to the peptidase S11 family
DESCA_RS02210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESCA_RS02240	COG1027	Aspartate ammonia-lyase
DESCA_RS02245	COG1151	hydroxylamine reductase activity
DESCA_RS02255	COG0390	transport system, permease component
DESCA_RS02260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DESCA_RS02290	COG0411	ABC transporter
DESCA_RS02300	COG0735	belongs to the Fur family
DESCA_RS02305	COG1773	rubredoxin
DESCA_RS02305	COG1592	Rubrerythrin
DESCA_RS02315	COG1406	Chemotaxis phosphatase CheX
DESCA_RS02330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DESCA_RS02395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DESCA_RS02400	COG0569	domain protein
DESCA_RS02405	COG3546	catalase activity
DESCA_RS02420	COG0166	Belongs to the GPI family
DESCA_RS02435	COG0165	Argininosuccinate lyase
DESCA_RS02435	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DESCA_RS02440	COG0440	acetolactate synthase activity
DESCA_RS02445	COG0864	Transcriptional regulator
DESCA_RS02450	COG2337	Toxic component of a toxin-antitoxin (TA) module
DESCA_RS02455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DESCA_RS02460	COG1228	amidohydrolase
DESCA_RS02470	COG0352	thiamine-phosphate diphosphorylase activity
DESCA_RS02475	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DESCA_RS02485	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DESCA_RS02490	COG0802	atpase or kinase
DESCA_RS02495	COG1214	PFAM Peptidase M22, glycoprotease
DESCA_RS02500	COG0456	acetyltransferase
DESCA_RS02505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DESCA_RS02510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESCA_RS02515	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DESCA_RS02525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DESCA_RS02545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DESCA_RS02555	COG0303	'Molybdopterin
DESCA_RS02560	COG1910	domain protein
DESCA_RS02570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DESCA_RS02575	COG0521	Mo-molybdopterin cofactor biosynthetic process
DESCA_RS02585	COG0459	protein refolding
DESCA_RS02590	COG2807	transmembrane transport
DESCA_RS02600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DESCA_RS02605	COG3275	phosphorelay sensor kinase activity
DESCA_RS02610	COG3279	Response regulator of the LytR AlgR family
DESCA_RS02615	COG0736	holo-[acyl-carrier-protein] synthase activity
DESCA_RS02620	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DESCA_RS02620	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DESCA_RS02625	COG0686	Belongs to the AlaDH PNT family
DESCA_RS02630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DESCA_RS02635	COG2201	protein-glutamate methylesterase activity
DESCA_RS02645	COG1215	transferase activity, transferring glycosyl groups
DESCA_RS02655	COG0840	transmembrane signaling receptor activity
DESCA_RS02660	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DESCA_RS02675	COG1331	Highly conserved protein containing a thioredoxin domain
DESCA_RS02750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DESCA_RS02760	COG0840	transmembrane signaling receptor activity
DESCA_RS02765	COG0367	asparagine synthase
DESCA_RS02800	COG0070	glutamate synthase
DESCA_RS02800	COG0069	glutamate synthase activity
DESCA_RS02800	COG0067	glutamate synthase
DESCA_RS02805	COG0493	'glutamate synthase
DESCA_RS02810	COG0004	ammonium transporteR
DESCA_RS02820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DESCA_RS02825	COG1027	Aspartate ammonia-lyase
DESCA_RS02830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DESCA_RS02830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DESCA_RS02850	COG3409	Peptidoglycan-binding domain 1 protein
DESCA_RS02850	COG3773	Cell wall hydrolase
DESCA_RS02855	COG0039	L-malate dehydrogenase activity
DESCA_RS02890	COG1518	maintenance of DNA repeat elements
DESCA_RS02920	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DESCA_RS02950	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DESCA_RS02965	COG2204	response regulator
DESCA_RS02970	COG4191	Histidine kinase
DESCA_RS02980	COG0730	response to heat
DESCA_RS03005	COG0733	neurotransmitter:sodium symporter activity
DESCA_RS03015	COG0791	NLP P60 protein
DESCA_RS03015	COG1388	LysM domain
DESCA_RS03020	COG1361	Conserved repeat domain
DESCA_RS03035	COG4822	anaerobic cobalamin biosynthetic process
DESCA_RS03040	COG1739	Uncharacterized protein family UPF0029
DESCA_RS03060	COG1337	RAMP superfamily
DESCA_RS03075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DESCA_RS03085	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DESCA_RS03130	COG1492	cobalamin metabolic process
DESCA_RS03140	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DESCA_RS03150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DESCA_RS03195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DESCA_RS03205	COG4865	methylaspartate mutase activity
DESCA_RS03210	COG3799	methylaspartate ammonia-lyase activity
DESCA_RS03225	COG1234	tRNA 3'-trailer cleavage
DESCA_RS03235	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DESCA_RS03240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DESCA_RS03260	COG3973	AAA domain
DESCA_RS03270	COG3835	regulator
DESCA_RS03275	COG0747	negative chemotaxis
DESCA_RS03280	COG0601	transmembrane transport
DESCA_RS03285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DESCA_RS03290	COG0444	Belongs to the ABC transporter superfamily
DESCA_RS03310	COG4608	Belongs to the ABC transporter superfamily
DESCA_RS03330	COG0385	Bile acid
DESCA_RS03335	COG3973	AAA domain
DESCA_RS03350	COG1201	RNA secondary structure unwinding
DESCA_RS03370	COG3344	reverse transcriptase
DESCA_RS03375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DESCA_RS03400	COG2433	Pfam Transposase IS66
DESCA_RS03505	COG4120	Belongs to the binding-protein-dependent transport system permease family
DESCA_RS03510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DESCA_RS03510	COG1116	anion transmembrane transporter activity
DESCA_RS03525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DESCA_RS03535	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESCA_RS03545	COG2333	competence protein COMEC
DESCA_RS03545	COG0658	competence protein
DESCA_RS03555	COG2155	Conserved Protein
DESCA_RS03560	COG2210	Belongs to the sulfur carrier protein TusA family
DESCA_RS03570	COG0446	pyridine nucleotide-disulphide oxidoreductase
DESCA_RS03585	COG0420	3'-5' exonuclease activity
DESCA_RS03625	COG0544	peptidyl-prolyl cis-trans isomerase activity
DESCA_RS03630	COG0740	serine-type endopeptidase activity
DESCA_RS03635	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DESCA_RS03640	COG0470	DNA polymerase III
DESCA_RS03640	COG1067	ATP-dependent peptidase activity
DESCA_RS03645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DESCA_RS03650	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DESCA_RS03660	COG0697	spore germination
DESCA_RS03675	COG0697	spore germination
DESCA_RS03705	COG0525	valine-tRNA ligase activity
DESCA_RS03710	COG1598	PFAM Uncharacterised protein family UPF0150
DESCA_RS03715	COG0285	dihydrofolate synthase activity
DESCA_RS03720	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DESCA_RS03730	COG0424	maF-like protein
DESCA_RS03735	COG2003	Belongs to the UPF0758 family
DESCA_RS03740	COG1077	Cell shape determining protein MreB Mrl
DESCA_RS03745	COG1792	Involved in formation and maintenance of cell shape
DESCA_RS03755	COG0768	penicillin binding
DESCA_RS03760	COG0850	regulation of cytokinetic process
DESCA_RS03765	COG2894	cell division
DESCA_RS03770	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DESCA_RS03775	COG0772	Belongs to the SEDS family
DESCA_RS03785	COG1994	Peptidase M50
DESCA_RS03805	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DESCA_RS03810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DESCA_RS03820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DESCA_RS03825	COG1489	DNA binding
DESCA_RS03855	COG1203	CRISPR-associated helicase, Cas3
DESCA_RS03865	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DESCA_RS03880	COG1484	DNA-dependent DNA replication
DESCA_RS03915	COG0411	ABC transporter
DESCA_RS03925	COG0831	urea catabolic process
DESCA_RS03930	COG0832	Belongs to the urease beta subunit family
DESCA_RS03935	COG0804	urea catabolic process
DESCA_RS04010	COG3835	regulator
DESCA_RS04015	COG2610	gluconate transmembrane transporter activity
DESCA_RS04020	COG1929	Belongs to the glycerate kinase type-1 family
DESCA_RS04045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DESCA_RS04060	COG5002	protein histidine kinase activity
DESCA_RS04065	COG0745	RESPONSE REGULATOR receiver
DESCA_RS04085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DESCA_RS04090	COG0022	dehydrogenase e1 component
DESCA_RS04095	COG3199	ATP-NAD kinase
DESCA_RS04100	COG0321	lipoyl(octanoyl) transferase activity
DESCA_RS04105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DESCA_RS04110	COG0508	dehydrogenase complex catalyzes the overall conversion of
DESCA_RS04150	COG0501	Belongs to the peptidase M48B family
DESCA_RS04170	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DESCA_RS04180	COG0017	Asparaginyl-tRNA synthetase
DESCA_RS04225	COG0735	belongs to the Fur family
DESCA_RS04235	COG3852	Histidine kinase
DESCA_RS04240	COG2204	response regulator
DESCA_RS04255	COG0427	acetyl-CoA hydrolase
DESCA_RS04275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DESCA_RS04285	COG1799	cell septum assembly
DESCA_RS04290	COG0037	tRNA processing
DESCA_RS04300	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DESCA_RS04320	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DESCA_RS04320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DESCA_RS04350	COG2059	Chromate
DESCA_RS04355	COG1802	Transcriptional regulator
DESCA_RS04365	COG1342	Belongs to the UPF0251 family
DESCA_RS04405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DESCA_RS04410	COG0243	molybdopterin cofactor binding
DESCA_RS04420	COG0564	pseudouridine synthase activity
DESCA_RS04435	COG1494	fructose-1,6-bisphosphatase
DESCA_RS04470	COG1242	4 iron, 4 sulfur cluster binding
DESCA_RS04475	COG1067	ATP-dependent peptidase activity
DESCA_RS04480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DESCA_RS04485	COG1113	amino acid transport
DESCA_RS04500	COG2414	aldehyde ferredoxin oxidoreductase
DESCA_RS04510	COG2720	vancomycin resistance protein
DESCA_RS04535	COG1671	Belongs to the UPF0178 family
DESCA_RS04550	COG0277	FAD linked oxidase domain protein
DESCA_RS04560	COG0840	transmembrane signaling receptor activity
DESCA_RS04570	COG2200	EAL domain
DESCA_RS04575	COG0745	RESPONSE REGULATOR receiver
DESCA_RS04580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DESCA_RS04590	COG0833	amino acid
DESCA_RS04595	COG1126	abc transporter atp-binding protein
DESCA_RS04600	COG0765	amino acid transport
DESCA_RS04605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESCA_RS04640	COG0463	Glycosyl transferase, family 2
DESCA_RS04640	COG1216	Glycosyl transferase, family 2
DESCA_RS04650	COG1091	dTDP-4-dehydrorhamnose reductase activity
DESCA_RS04660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DESCA_RS04665	COG1216	Glycosyl transferase, family 2
DESCA_RS04665	COG0438	transferase activity, transferring glycosyl groups
DESCA_RS04670	COG0457	Tetratricopeptide repeat
DESCA_RS04670	COG0463	Glycosyl transferase, family 2
DESCA_RS04675	COG0457	Tetratricopeptide repeat
DESCA_RS04675	COG0463	Glycosyl transferase, family 2
DESCA_RS04700	COG0463	Glycosyl transferase, family 2
DESCA_RS04700	COG0457	Tetratricopeptide repeat
DESCA_RS04705	COG0463	Glycosyl transferase, family 2
DESCA_RS04705	COG0457	Tetratricopeptide repeat
DESCA_RS04730	COG1982	Orn Lys Arg decarboxylase major
DESCA_RS04735	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DESCA_RS04740	COG1074	ATP-dependent DNA helicase activity
DESCA_RS04750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESCA_RS04780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DESCA_RS04790	COG0488	(ABC) transporter
DESCA_RS04795	COG2226	methyltransferase
DESCA_RS04860	COG0398	Pfam SNARE associated Golgi protein
DESCA_RS04865	COG2897	thiosulfate sulfurtransferase activity
DESCA_RS04890	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DESCA_RS04895	COG2081	HI0933 family
DESCA_RS04925	COG5557	Pfam Polysulphide reductase, NrfD
DESCA_RS04930	COG3064	Membrane
DESCA_RS04930	COG0437	4 iron, 4 sulfur cluster binding
DESCA_RS04940	COG0583	DNA-binding transcription factor activity
DESCA_RS04945	COG4122	O-methyltransferase activity
DESCA_RS04965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DESCA_RS04970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DESCA_RS04975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DESCA_RS04980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DESCA_RS04985	COG0297	glycogen (starch) synthase activity
DESCA_RS05005	COG0477	Major facilitator Superfamily
DESCA_RS05010	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DESCA_RS05030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DESCA_RS05040	COG2323	membrane
DESCA_RS05055	COG2323	membrane
DESCA_RS05070	COG3279	Response regulator of the LytR AlgR family
DESCA_RS05075	COG1966	Carbon starvation protein
DESCA_RS05085	COG0326	Molecular chaperone. Has ATPase activity
DESCA_RS05155	COG1757	Na H antiporter
DESCA_RS05180	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DESCA_RS05190	COG1397	ADP-ribosylglycohydrolase
DESCA_RS05195	COG1902	pentaerythritol trinitrate reductase activity
DESCA_RS05210	COG0280	phosphate acetyltransferase
DESCA_RS05215	COG3426	butyrate kinase activity
DESCA_RS05225	COG5002	protein histidine kinase activity
DESCA_RS05225	COG5001	Diguanylate cyclase
DESCA_RS05225	COG3447	MASE1 domain protein
DESCA_RS05240	COG5002	protein histidine kinase activity
DESCA_RS05240	COG5001	Diguanylate cyclase
DESCA_RS05280	COG5278	phosphoserine phosphatase activity
DESCA_RS05280	COG0840	transmembrane signaling receptor activity
DESCA_RS05300	COG0798	PFAM Bile acid sodium symporter
DESCA_RS05310	COG0640	Transcriptional regulator
DESCA_RS05320	COG0640	Transcriptional regulator
DESCA_RS05325	COG0640	Transcriptional regulator
DESCA_RS05370	COG3383	formate dehydrogenase (NAD+) activity
DESCA_RS05385	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DESCA_RS05390	COG0739	heme binding
DESCA_RS05390	COG1196	nuclear chromosome segregation
DESCA_RS05390	COG0741	lytic transglycosylase activity
DESCA_RS05395	COG0237	dephospho-CoA kinase activity
DESCA_RS05400	COG1971	Probably functions as a manganese efflux pump
DESCA_RS05405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DESCA_RS05415	COG0793	Belongs to the peptidase S41A family
DESCA_RS05415	COG3409	Peptidoglycan-binding domain 1 protein
DESCA_RS05420	COG0586	Pfam SNARE associated Golgi protein
DESCA_RS05425	COG0398	Pfam SNARE associated Golgi protein
DESCA_RS05435	COG1686	Belongs to the peptidase S11 family
DESCA_RS05455	COG0789	Transcriptional regulator
DESCA_RS05475	COG4399	Belongs to the UPF0754 family
DESCA_RS05480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DESCA_RS05495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DESCA_RS05500	COG1116	anion transmembrane transporter activity
DESCA_RS05505	COG0010	Belongs to the arginase family
DESCA_RS05515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DESCA_RS05520	COG1335	isochorismatase
DESCA_RS05530	COG0010	Belongs to the arginase family
DESCA_RS05545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DESCA_RS05550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DESCA_RS05555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DESCA_RS05580	COG4869	propanediol catabolic process
DESCA_RS05585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DESCA_RS05610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DESCA_RS05610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DESCA_RS05620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DESCA_RS05620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DESCA_RS05625	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DESCA_RS05630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DESCA_RS05635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DESCA_RS05645	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DESCA_RS05650	COG0742	ribosomal rna small subunit methyltransferase
DESCA_RS05655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DESCA_RS05665	COG0857	belongs to the CobB CobQ family
DESCA_RS05670	COG0045	succinate-CoA ligase (ADP-forming) activity
DESCA_RS05670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DESCA_RS05670	COG1042	CoA-binding domain protein
DESCA_RS05675	COG3314	Sporulation integral membrane protein YlbJ
DESCA_RS05685	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DESCA_RS05695	COG0416	fatty acid biosynthetic process
DESCA_RS05700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DESCA_RS05705	COG2070	2-Nitropropane dioxygenase
DESCA_RS05710	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DESCA_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
DESCA_RS05720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DESCA_RS05725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DESCA_RS05730	COG0571	ribonuclease III activity
DESCA_RS05735	COG1196	nuclear chromosome segregation
DESCA_RS05740	COG0552	protein localization to endoplasmic reticulum
DESCA_RS05745	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DESCA_RS05750	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DESCA_RS05755	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DESCA_RS05765	COG0402	S-adenosylhomocysteine deaminase activity
DESCA_RS05780	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DESCA_RS05785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DESCA_RS05790	COG0228	four-way junction DNA binding
DESCA_RS05805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DESCA_RS05810	COG0336	Belongs to the RNA methyltransferase TrmD family
DESCA_RS05815	COG0335	large ribosomal subunit rRNA binding
DESCA_RS05820	COG0681	Belongs to the peptidase S26 family
DESCA_RS05825	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DESCA_RS05830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DESCA_RS05835	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESCA_RS05840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESCA_RS05845	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESCA_RS05850	COG0649	NAD binding
DESCA_RS05855	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DESCA_RS05875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DESCA_RS05880	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DESCA_RS05885	COG1007	ATP synthesis coupled electron transport
DESCA_RS05890	COG0792	nuclease activity
DESCA_RS05900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESCA_RS05910	COG3328	transposase activity
DESCA_RS05920	COG0606	chelatase, subunit chli
DESCA_RS05965	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
DESCA_RS05970	COG0347	Belongs to the P(II) protein family
DESCA_RS05975	COG0347	Belongs to the P(II) protein family
DESCA_RS06000	COG1433	Dinitrogenase iron-molybdenum cofactor
DESCA_RS06000	COG0535	radical SAM domain protein
DESCA_RS06010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESCA_RS06035	COG1151	hydroxylamine reductase activity
DESCA_RS06060	COG1484	DNA-dependent DNA replication
DESCA_RS06065	COG3328	transposase activity
DESCA_RS06075	COG2839	Protein conserved in bacteria
DESCA_RS06090	COG2766	serine protein kinase
DESCA_RS06095	COG2718	Belongs to the UPF0229 family
DESCA_RS06100	COG2719	SpoVR family
DESCA_RS06105	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DESCA_RS06110	COG1793	dna ligase
DESCA_RS06110	COG3285	dna ligase
DESCA_RS06115	COG2204	response regulator
DESCA_RS06120	COG3852	Histidine kinase
DESCA_RS06145	COG0659	secondary active sulfate transmembrane transporter activity
DESCA_RS06200	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DESCA_RS06250	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DESCA_RS06290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DESCA_RS06295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DESCA_RS06300	COG0569	domain protein
DESCA_RS06305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DESCA_RS06310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DESCA_RS06315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DESCA_RS06315	COG0072	phenylalanine-tRNA ligase activity
DESCA_RS06320	COG0730	response to heat
DESCA_RS06325	COG0352	thiamine-phosphate diphosphorylase activity
DESCA_RS06330	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DESCA_RS06335	COG1796	DNA polymerase
DESCA_RS06335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DESCA_RS06340	COG2094	Belongs to the DNA glycosylase MPG family
DESCA_RS06350	COG0826	peptidase U32
DESCA_RS06355	COG1193	negative regulation of DNA recombination
DESCA_RS06360	COG0501	Belongs to the peptidase M48B family
DESCA_RS06365	COG2032	superoxide dismutase activity
DESCA_RS06375	COG1115	amino acid carrier protein
DESCA_RS06380	COG1757	Na H antiporter
DESCA_RS06390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DESCA_RS06390	COG4499	WXG100 protein secretion system (Wss), protein YukC
DESCA_RS06395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DESCA_RS06460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DESCA_RS06465	COG0217	transcriptional regulatory protein
DESCA_RS06475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DESCA_RS06480	COG0632	four-way junction helicase activity
DESCA_RS06485	COG2255	four-way junction helicase activity
DESCA_RS06495	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DESCA_RS06505	COG2385	sporulation resulting in formation of a cellular spore
DESCA_RS06510	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DESCA_RS06515	COG0343	queuine tRNA-ribosyltransferase activity
DESCA_RS06520	COG1862	Preprotein translocase
DESCA_RS06530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DESCA_RS06535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DESCA_RS06545	COG2848	UPF0210 protein
DESCA_RS06550	COG0564	pseudouridine synthase activity
DESCA_RS06565	COG2707	UPF0756 membrane protein
DESCA_RS06570	COG3773	Cell wall hydrolase
DESCA_RS06570	COG3409	Peptidoglycan-binding domain 1 protein
DESCA_RS06575	COG1809	phosphosulfolactate synthase activity
DESCA_RS06580	COG2814	Major facilitator Superfamily
DESCA_RS06590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DESCA_RS06595	COG0540	Belongs to the ATCase OTCase family
DESCA_RS06600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DESCA_RS06605	COG0505	Belongs to the CarA family
DESCA_RS06610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DESCA_RS06615	COG0543	2 iron, 2 sulfur cluster binding
DESCA_RS06620	COG0167	dihydroorotate dehydrogenase activity
DESCA_RS06625	COG0284	orotidine-5'-phosphate decarboxylase activity
DESCA_RS06630	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DESCA_RS06635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DESCA_RS06645	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DESCA_RS06650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DESCA_RS06660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DESCA_RS06665	COG0436	Aminotransferase
DESCA_RS06675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DESCA_RS06680	COG1561	YicC-like family, N-terminal region
DESCA_RS06685	COG2052	Domain of unknown function (DUF370)
DESCA_RS06690	COG0194	GDP metabolic process
DESCA_RS06695	COG1758	RNA polymerase activity
DESCA_RS06700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DESCA_RS06705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DESCA_RS06710	COG0242	peptide deformylase activity
DESCA_RS06715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DESCA_RS06725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DESCA_RS06725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DESCA_RS06730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DESCA_RS06735	COG1716	ATPase activity
DESCA_RS06740	COG1716	ATPase activity
DESCA_RS06745	COG0631	protein serine/threonine phosphatase activity
DESCA_RS06750	COG0772	Belongs to the SEDS family
DESCA_RS06755	COG0768	penicillin binding
DESCA_RS06760	COG2815	serine threonine protein kinase
DESCA_RS06760	COG0515	serine threonine protein kinase
DESCA_RS06765	COG1162	GTPase activity
DESCA_RS06770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DESCA_RS06780	COG0563	adenylate kinase activity
DESCA_RS06785	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DESCA_RS06795	COG0559	Belongs to the binding-protein-dependent transport system permease family
DESCA_RS06805	COG0411	ABC transporter
DESCA_RS06815	COG2204	response regulator
DESCA_RS06845	COG3829	transcription factor binding
DESCA_RS06845	COG3290	protein histidine kinase activity
DESCA_RS06855	COG0446	pyridine nucleotide-disulphide oxidoreductase
DESCA_RS06880	COG2414	aldehyde ferredoxin oxidoreductase
DESCA_RS06895	COG0674	pyruvate-flavodoxin oxidoreductase activity
DESCA_RS06895	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DESCA_RS06900	COG1013	pyruvate-flavodoxin oxidoreductase activity
DESCA_RS06910	COG0697	spore germination
DESCA_RS06930	COG0492	ferredoxin-NADP+ reductase activity
DESCA_RS06935	COG0045	succinate-CoA ligase (ADP-forming) activity
DESCA_RS06940	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DESCA_RS06945	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DESCA_RS06950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DESCA_RS06960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DESCA_RS06960	COG1199	ATP-dependent helicase activity
DESCA_RS06965	COG1183	phosphatidylcholine synthase activity
DESCA_RS06970	COG4191	Histidine kinase
DESCA_RS06990	COG0492	ferredoxin-NADP+ reductase activity
DESCA_RS07005	COG0720	synthase
DESCA_RS07010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DESCA_RS07020	COG0602	queuosine metabolic process
DESCA_RS07025	COG0302	gtp cyclohydrolase
DESCA_RS07035	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DESCA_RS07045	COG2244	polysaccharide biosynthetic process
DESCA_RS07050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DESCA_RS07070	COG1181	Belongs to the D-alanine--D-alanine ligase family
DESCA_RS07080	COG1615	UPF0182 protein
DESCA_RS07125	COG1610	YqeY-like protein
DESCA_RS07140	COG0531	amino acid
DESCA_RS07155	COG3829	transcription factor binding
DESCA_RS07165	COG3048	D-serine ammonia-lyase activity
DESCA_RS07175	COG0617	tRNA 3'-terminal CCA addition
DESCA_RS07175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DESCA_RS07175	COG0517	IMP dehydrogenase activity
DESCA_RS07185	COG1966	Carbon starvation protein
DESCA_RS07190	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DESCA_RS07205	COG3328	transposase activity
DESCA_RS07215	COG0039	L-malate dehydrogenase activity
DESCA_RS07220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DESCA_RS07225	COG1053	succinate dehydrogenase
DESCA_RS07250	COG3829	transcription factor binding
DESCA_RS07250	COG3290	protein histidine kinase activity
DESCA_RS07270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DESCA_RS07300	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DESCA_RS07300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DESCA_RS07310	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DESCA_RS07315	COG0464	growth
DESCA_RS07320	COG1923	regulation of RNA biosynthetic process
DESCA_RS07325	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DESCA_RS07330	COG2136	Putative SAM-dependent methyltransferase
DESCA_RS07330	COG2521	methyltransferase
DESCA_RS07335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DESCA_RS07350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DESCA_RS07355	COG3679	Belongs to the UPF0342 family
DESCA_RS07360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESCA_RS07365	COG2855	membrane
DESCA_RS07375	COG2197	response regulator
DESCA_RS07380	COG4585	Histidine kinase
DESCA_RS07385	COG2855	membrane
DESCA_RS07385	COG2855	membrane
DESCA_RS07400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DESCA_RS07405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DESCA_RS07410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DESCA_RS07415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DESCA_RS07420	COG0463	Glycosyl transferase, family 2
DESCA_RS07430	COG0850	regulation of cytokinetic process
DESCA_RS07435	COG0494	nUDIX hydrolase
DESCA_RS07440	COG5002	protein histidine kinase activity
DESCA_RS07445	COG0745	RESPONSE REGULATOR receiver
DESCA_RS07450	COG3328	transposase activity
DESCA_RS07455	COG0489	protein tyrosine kinase activity
DESCA_RS07465	COG0454	-acetyltransferase
DESCA_RS07470	COG0516	GMP reductase activity
DESCA_RS07470	COG0517	IMP dehydrogenase activity
DESCA_RS07505	COG0436	Aminotransferase
DESCA_RS07510	COG0613	PHP domain protein
DESCA_RS07520	COG2359	stage V sporulation protein S
DESCA_RS07525	COG1692	metallophosphoesterase
DESCA_RS07535	COG1418	mRNA catabolic process
DESCA_RS07540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DESCA_RS07545	COG0513	Belongs to the DEAD box helicase family
DESCA_RS07550	COG1058	Belongs to the CinA family
DESCA_RS07550	COG1546	Belongs to the CinA family
DESCA_RS07555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DESCA_RS07565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DESCA_RS07570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESCA_RS07575	COG1666	GTP binding
DESCA_RS07580	COG0758	DNA mediated transformation
DESCA_RS07595	COG1426	Protein conserved in bacteria
DESCA_RS07600	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DESCA_RS07605	COG1674	ftsk spoiiie
DESCA_RS07625	COG0740	serine-type endopeptidase activity
DESCA_RS07630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DESCA_RS07635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DESCA_RS07640	COG0527	aspartate kinase activity
DESCA_RS07645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DESCA_RS07650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DESCA_RS07655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DESCA_RS07675	COG0612	Peptidase, M16
DESCA_RS07680	COG0726	polysaccharide deacetylase
DESCA_RS07690	COG1185	polyribonucleotide nucleotidyltransferase activity
DESCA_RS07695	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DESCA_RS07710	COG0196	riboflavin kinase activity
DESCA_RS07715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DESCA_RS07720	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DESCA_RS07725	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DESCA_RS07730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DESCA_RS07740	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DESCA_RS07745	COG0195	Participates in both transcription termination and antitermination
DESCA_RS07750	COG0779	Required for maturation of 30S ribosomal subunits
DESCA_RS07775	COG0442	prolyl-tRNA aminoacylation
DESCA_RS07780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DESCA_RS07785	COG0750	zinc metalloprotease
DESCA_RS07790	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DESCA_RS07795	COG0628	permease
DESCA_RS07800	COG0575	Belongs to the CDS family
DESCA_RS07820	COG0233	cytoplasmic translational termination
DESCA_RS07825	COG0528	UMP kinase activity
DESCA_RS07830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DESCA_RS07835	COG0052	Belongs to the universal ribosomal protein uS2 family
DESCA_RS07845	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DESCA_RS07850	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DESCA_RS07855	COG4974	Belongs to the 'phage' integrase family
DESCA_RS07860	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DESCA_RS07865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DESCA_RS07870	COG0758	DNA mediated transformation
DESCA_RS07870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DESCA_RS07875	COG1793	dna ligase
DESCA_RS07875	COG3285	dna ligase
DESCA_RS07885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DESCA_RS07935	COG1509	lysine 2,3-aminomutase activity
DESCA_RS07950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DESCA_RS07960	COG0835	chemotaxis
DESCA_RS07965	COG0393	Putative heavy-metal-binding
DESCA_RS07975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DESCA_RS07980	COG1522	sequence-specific DNA binding
DESCA_RS07985	COG1522	sequence-specific DNA binding
DESCA_RS07990	COG0535	radical SAM domain protein
DESCA_RS07995	COG0113	porphobilinogen synthase activity
DESCA_RS08000	COG0535	radical SAM domain protein
DESCA_RS08010	COG0181	hydroxymethylbilane synthase activity
DESCA_RS08015	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DESCA_RS08020	COG1648	precorrin-2 dehydrogenase activity
DESCA_RS08020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DESCA_RS08025	COG0142	geranyltranstransferase activity
DESCA_RS08055	COG0589	response to stress
DESCA_RS08065	COG1278	Cold shock
DESCA_RS08075	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DESCA_RS08080	COG4149	molybdate abc transporter
DESCA_RS08085	COG0725	ABC transporter, periplasmic molybdate-binding protein
DESCA_RS08090	COG1910	domain protein
DESCA_RS08095	COG0588	phosphoglycerate mutase activity
DESCA_RS08100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DESCA_RS08105	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DESCA_RS08105	COG3608	succinylglutamate desuccinylase aspartoacylase
DESCA_RS08110	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DESCA_RS08115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DESCA_RS08125	COG2226	methyltransferase
DESCA_RS08180	COG1921	L-seryl-tRNASec selenium transferase activity
DESCA_RS08185	COG2186	Transcriptional regulator
DESCA_RS08190	COG1620	l-lactate permease
DESCA_RS08200	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DESCA_RS08205	COG1592	Rubrerythrin
DESCA_RS08210	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DESCA_RS08215	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DESCA_RS08220	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DESCA_RS08225	COG0109	protoheme IX farnesyltransferase activity
DESCA_RS08230	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DESCA_RS08235	COG2226	methyltransferase
DESCA_RS08245	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DESCA_RS08280	COG0646	methionine synthase
DESCA_RS08280	COG1410	methionine synthase
DESCA_RS08290	COG2081	HI0933 family
DESCA_RS08295	COG0012	GTP binding
DESCA_RS08300	COG1592	Rubrerythrin
DESCA_RS08310	COG3706	GGDEF domain
DESCA_RS08315	COG0463	Glycosyl transferase, family 2
DESCA_RS08385	COG3328	transposase activity
DESCA_RS08415	COG5278	phosphoserine phosphatase activity
DESCA_RS08415	COG0840	transmembrane signaling receptor activity
DESCA_RS08425	COG2217	Heavy metal translocating P-type atpase
DESCA_RS08435	COG5002	protein histidine kinase activity
DESCA_RS08440	COG0745	RESPONSE REGULATOR receiver
DESCA_RS08515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DESCA_RS08525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DESCA_RS08540	COG2814	Major facilitator Superfamily
DESCA_RS08550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DESCA_RS08560	COG0315	cyclic pyranopterin monophosphate synthase activity
DESCA_RS08565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DESCA_RS08570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DESCA_RS08590	COG2204	response regulator
DESCA_RS08610	COG3344	reverse transcriptase
DESCA_RS08620	COG1454	alcohol dehydrogenase
DESCA_RS08625	COG3706	GGDEF domain
DESCA_RS08630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DESCA_RS08635	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESCA_RS08645	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DESCA_RS08675	COG0598	Magnesium transport protein CorA
DESCA_RS08680	COG2755	lipolytic protein G-D-S-L family
DESCA_RS08685	COG1191	sigma factor activity
DESCA_RS08690	COG0159	tryptophan synthase activity
DESCA_RS08695	COG0133	tryptophan synthase activity
DESCA_RS08700	COG0135	phosphoribosylanthranilate isomerase activity
DESCA_RS08705	COG0134	indole-3-glycerol-phosphate synthase activity
DESCA_RS08710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DESCA_RS08715	COG0512	Glutamine amidotransferase of anthranilate synthase
DESCA_RS08715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DESCA_RS08750	COG0205	6-phosphofructokinase activity
DESCA_RS08755	COG0825	malonyl-CoA metabolic process
DESCA_RS08760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DESCA_RS08790	COG0791	NLP P60 protein
DESCA_RS08815	COG0438	transferase activity, transferring glycosyl groups
DESCA_RS08820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DESCA_RS08825	COG1543	Belongs to the glycosyl hydrolase 57 family
DESCA_RS08835	COG2431	L-lysine efflux transmembrane transporter activity
DESCA_RS08845	COG1832	CoA-binding protein
DESCA_RS08850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DESCA_RS08855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DESCA_RS08865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DESCA_RS08880	COG1842	Phage shock protein A
DESCA_RS08900	COG0473	3-isopropylmalate dehydrogenase activity
DESCA_RS08905	COG0066	3-isopropylmalate dehydratase activity
DESCA_RS08910	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DESCA_RS08915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESCA_RS08920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DESCA_RS08925	COG0154	amidase activity
DESCA_RS08930	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DESCA_RS08940	COG1361	Conserved repeat domain
DESCA_RS08940	COG3266	domain, Protein
DESCA_RS08940	COG2911	Protein conserved in bacteria
DESCA_RS08950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DESCA_RS08970	COG0107	imidazoleglycerol-phosphate synthase activity
DESCA_RS08975	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DESCA_RS08980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DESCA_RS08985	COG0131	Imidazoleglycerol-phosphate dehydratase
DESCA_RS09000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DESCA_RS09015	COG0124	histidyl-tRNA synthetase
DESCA_RS09020	COG4496	protein, YerC YecD
DESCA_RS09030	COG0138	bifunctional purine biosynthesis protein purh
DESCA_RS09035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DESCA_RS09040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DESCA_RS09050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DESCA_RS09055	COG0047	phosphoribosylformylglycinamidine synthase activity
DESCA_RS09060	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DESCA_RS09065	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DESCA_RS09070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DESCA_RS09075	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DESCA_RS09080	COG2252	PERMEase
DESCA_RS09090	COG0519	Catalyzes the synthesis of GMP from XMP
DESCA_RS09090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DESCA_RS09095	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DESCA_RS09105	COG1694	Mazg nucleotide pyrophosphohydrolase
DESCA_RS09115	COG1776	CheC inhibitor of MCP methylation
DESCA_RS09115	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DESCA_RS09120	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DESCA_RS09125	COG2201	protein-glutamate methylesterase activity
DESCA_RS09135	COG1776	CheC inhibitor of MCP methylation
DESCA_RS09140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DESCA_RS09145	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DESCA_RS09155	COG4786	Flagellar basal body rod
DESCA_RS09160	COG1191	sigma factor activity
DESCA_RS09175	COG1419	protein localization to endoplasmic reticulum
DESCA_RS09180	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DESCA_RS09185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DESCA_RS09190	COG1684	flagellar biosynthetic protein fliR
DESCA_RS09195	COG1987	bacterial-type flagellum assembly
DESCA_RS09200	COG1338	Plays a role in the flagellum-specific transport system
DESCA_RS09220	COG4786	Flagellar basal body rod
DESCA_RS09230	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DESCA_RS09235	COG3144	bacterial-type flagellum assembly
DESCA_RS09245	COG1157	protein secretion by the type III secretion system
DESCA_RS09250	COG1317	bacterial-type flagellum organization
DESCA_RS09255	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DESCA_RS09260	COG1766	The M ring may be actively involved in energy transduction
DESCA_RS09265	COG1677	Flagellar hook-basal body complex protein FliE
DESCA_RS09275	COG1815	bacterial-type flagellum-dependent cell motility
DESCA_RS09280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DESCA_RS09305	COG1516	flagellar protein fliS
DESCA_RS09310	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DESCA_RS09315	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DESCA_RS09320	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DESCA_RS09395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DESCA_RS09415	COG1256	bacterial-type flagellum assembly
DESCA_RS09415	COG4786	Flagellar basal body rod
DESCA_RS09430	COG2201	protein-glutamate methylesterase activity
DESCA_RS09435	COG0643	Histidine kinase
DESCA_RS09435	COG2198	Histidine kinase
DESCA_RS09455	COG3547	Transposase (IS116 IS110 IS902 family)
DESCA_RS09460	COG2045	Belongs to the ComB family
DESCA_RS09485	COG0546	phosphoglycolate phosphatase activity
DESCA_RS09500	COG3706	GGDEF domain
DESCA_RS09515	COG0328	RNA-DNA hybrid ribonuclease activity
DESCA_RS09520	COG1164	Oligoendopeptidase f
DESCA_RS09525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DESCA_RS09530	COG2384	SAM-dependent methyltransferase
DESCA_RS09535	COG0840	transmembrane signaling receptor activity
DESCA_RS09560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DESCA_RS09565	COG0358	DNA primase activity
DESCA_RS09570	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DESCA_RS09575	COG0431	NADPH-dependent FMN reductase
DESCA_RS09580	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DESCA_RS09585	COG0574	Belongs to the PEP-utilizing enzyme family
DESCA_RS09585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DESCA_RS09590	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DESCA_RS09595	COG0517	IMP dehydrogenase activity
DESCA_RS09600	COG0751	glycine-tRNA ligase activity
DESCA_RS09605	COG0752	glycyl-tRNA synthetase alpha subunit
DESCA_RS09615	COG1381	Involved in DNA repair and RecF pathway recombination
DESCA_RS09620	COG1773	rubredoxin
DESCA_RS09620	COG1592	Rubrerythrin
DESCA_RS09630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DESCA_RS09640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DESCA_RS09645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DESCA_RS09650	COG1480	7TM receptor with intracellular HD hydrolase
DESCA_RS09655	COG1702	phosphate starvation-inducible protein PhoH
DESCA_RS09670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DESCA_RS09675	COG0537	adenosine 5'-monophosphoramidase activity
DESCA_RS09680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DESCA_RS09685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DESCA_RS09690	COG2264	protein methyltransferase activity
DESCA_RS09695	COG0484	heat shock protein binding
DESCA_RS09700	COG0443	Heat shock 70 kDa protein
DESCA_RS09705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DESCA_RS09710	COG0459	protein refolding
DESCA_RS09715	COG1420	regulation of RNA biosynthetic process
DESCA_RS09720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DESCA_RS09725	COG0481	GTPase activity
DESCA_RS09745	COG0268	Binds directly to 16S ribosomal RNA
DESCA_RS09755	COG0011	TIGRFAM Protein of
DESCA_RS09760	COG0860	N-Acetylmuramoyl-L-alanine amidase
DESCA_RS09760	COG2247	cell wall binding repeat
DESCA_RS09765	COG0658	competence protein
DESCA_RS09765	COG2333	competence protein COMEC
DESCA_RS09770	COG0741	lytic transglycosylase activity
DESCA_RS09775	COG1555	photosystem II stabilization
DESCA_RS09780	COG2323	membrane
DESCA_RS09785	COG0495	leucyl-tRNA aminoacylation
DESCA_RS09790	COG0318	PFAM AMP-dependent synthetase and ligase
DESCA_RS09795	COG0799	negative regulation of ribosome biogenesis
DESCA_RS09800	COG1713	HD superfamily hydrolase involved in NAD metabolism
DESCA_RS09805	COG0724	RNA recognition motif
DESCA_RS09810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DESCA_RS09825	COG1879	ABC-type sugar transport system periplasmic component
DESCA_RS09830	COG1172	Belongs to the binding-protein-dependent transport system permease family
DESCA_RS09835	COG1129	ABC transporter
DESCA_RS09840	COG1869	D-ribose catabolic process
DESCA_RS09845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DESCA_RS09875	COG1484	DNA-dependent DNA replication
DESCA_RS09890	COG0477	Major facilitator Superfamily
DESCA_RS09905	COG1122	ATPase activity
DESCA_RS09915	COG0310	cobalt ion transport
DESCA_RS09920	COG3135	benzoate transporter
DESCA_RS09935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DESCA_RS09940	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DESCA_RS09960	COG1414	Transcriptional regulator
DESCA_RS09970	COG0006	proline dipeptidase activity
DESCA_RS09980	COG1691	(AIR) carboxylase
DESCA_RS09990	COG1606	tRNA processing
DESCA_RS09995	COG0840	transmembrane signaling receptor activity
DESCA_RS10005	COG2414	aldehyde ferredoxin oxidoreductase
DESCA_RS10050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DESCA_RS10085	COG1773	rubredoxin
DESCA_RS10085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DESCA_RS10090	COG0352	thiamine-phosphate diphosphorylase activity
DESCA_RS10090	COG0351	phosphomethylpyrimidine kinase
DESCA_RS10095	COG1846	Transcriptional regulator
DESCA_RS10100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DESCA_RS10110	COG1760	l-serine dehydratase
DESCA_RS10115	COG1760	l-serine dehydratase
DESCA_RS10140	COG0493	'glutamate synthase
DESCA_RS10170	COG0425	Belongs to the sulfur carrier protein TusA family
DESCA_RS10175	COG0709	Synthesizes selenophosphate from selenide and ATP
DESCA_RS10185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DESCA_RS10200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DESCA_RS10235	COG0248	Ppx GppA phosphatase
DESCA_RS10245	COG3290	protein histidine kinase activity
DESCA_RS10245	COG0840	transmembrane signaling receptor activity
DESCA_RS10260	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DESCA_RS10290	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DESCA_RS10295	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DESCA_RS10335	COG0083	homoserine kinase activity
DESCA_RS10340	COG0460	homoserine dehydrogenase
DESCA_RS10345	COG4492	Belongs to the UPF0735 family
DESCA_RS10350	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DESCA_RS10360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DESCA_RS10365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DESCA_RS10370	COG1160	GTP binding
DESCA_RS10375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESCA_RS10400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DESCA_RS10400	COG0539	negative regulation of cytoplasmic translation
DESCA_RS10405	COG0204	Acyl-transferase
DESCA_RS10410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DESCA_RS10415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DESCA_RS10420	COG0287	Prephenate dehydrogenase
DESCA_RS10425	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DESCA_RS10430	COG0436	Aminotransferase
DESCA_RS10435	COG4401	Chorismate mutase type I
DESCA_RS10460	COG1187	pseudouridine synthase activity
DESCA_RS10465	COG0700	Nucleoside recognition
DESCA_RS10470	COG2715	membrane protein required for spore maturation
DESCA_RS10475	COG3852	Histidine kinase
DESCA_RS10480	COG3874	Sporulation protein YtfJ
DESCA_RS10495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DESCA_RS10505	COG0180	Tryptophanyl-tRNA synthetase
DESCA_RS10510	COG1994	Peptidase M50
DESCA_RS10515	COG3620	sequence-specific DNA binding
DESCA_RS10515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DESCA_RS10515	COG0617	tRNA 3'-terminal CCA addition
DESCA_RS10520	COG0019	diaminopimelate decarboxylase activity
DESCA_RS10540	COG0697	spore germination
DESCA_RS10550	COG2183	response to ionizing radiation
DESCA_RS10555	COG1924	4 iron, 4 sulfur cluster binding
DESCA_RS10575	COG3383	formate dehydrogenase (NAD+) activity
DESCA_RS10580	COG3383	formate dehydrogenase (NAD+) activity
DESCA_RS10590	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DESCA_RS10595	COG0805	protein transport
DESCA_RS10605	COG5557	Pfam Polysulphide reductase, NrfD
DESCA_RS10610	COG0437	4 iron, 4 sulfur cluster binding
DESCA_RS10635	COG0697	spore germination
DESCA_RS10655	COG1366	Belongs to the anti-sigma-factor antagonist family
DESCA_RS10660	COG1686	Belongs to the peptidase S11 family
DESCA_RS10670	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DESCA_RS10675	COG4974	Belongs to the 'phage' integrase family
DESCA_RS10690	COG2707	UPF0756 membrane protein
DESCA_RS10720	COG2195	Cleaves the N-terminal amino acid of tripeptides
DESCA_RS10770	COG0745	RESPONSE REGULATOR receiver
DESCA_RS10775	COG0750	zinc metalloprotease
DESCA_RS10780	COG0497	DNA recombination
DESCA_RS10785	COG1438	arginine binding
DESCA_RS10790	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DESCA_RS10795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DESCA_RS10805	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DESCA_RS10810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DESCA_RS10815	COG4988	ABC transporter
DESCA_RS10820	COG1294	oxidase, subunit
DESCA_RS10825	COG1271	oxidase subunit
DESCA_RS10830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DESCA_RS10845	COG1722	exodeoxyribonuclease VII activity
DESCA_RS10855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DESCA_RS10860	COG1570	exodeoxyribonuclease VII activity
DESCA_RS10865	COG0493	'glutamate synthase
DESCA_RS10865	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DESCA_RS10875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DESCA_RS10890	COG1302	Protein conserved in bacteria
DESCA_RS10895	COG0439	Biotin carboxylase
DESCA_RS10940	COG3854	ATPases associated with a variety of cellular activities
DESCA_RS10950	COG0446	pyridine nucleotide-disulphide oxidoreductase
DESCA_RS10960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DESCA_RS10965	COG0006	proline dipeptidase activity
DESCA_RS10970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DESCA_RS10975	COG0312	modulator of DNA gyrase
DESCA_RS10985	COG0477	Major facilitator Superfamily
DESCA_RS11010	COG1113	amino acid transport
DESCA_RS11015	COG0686	Belongs to the AlaDH PNT family
DESCA_RS11020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DESCA_RS11025	COG2011	ABC-type metal ion transport system permease component
DESCA_RS11035	COG1191	sigma factor activity
DESCA_RS11045	COG1392	Phosphate transport regulator
DESCA_RS11050	COG0306	phosphate transporter
DESCA_RS11065	COG2814	Major facilitator Superfamily
DESCA_RS11075	COG2962	Rard protein
DESCA_RS11090	COG3328	transposase activity
DESCA_RS11105	COG1482	cell wall glycoprotein biosynthetic process
DESCA_RS11130	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DESCA_RS11135	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
DESCA_RS11140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DESCA_RS11150	COG0071	Belongs to the small heat shock protein (HSP20) family
DESCA_RS11165	COG0312	modulator of DNA gyrase
DESCA_RS11225	COG1459	type II secretion system
DESCA_RS11235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DESCA_RS11240	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DESCA_RS11245	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DESCA_RS11250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DESCA_RS11255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DESCA_RS11260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DESCA_RS11265	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DESCA_RS11275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DESCA_RS11355	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DESCA_RS11355	COG2199	diguanylate cyclase activity
DESCA_RS11380	COG3118	belongs to the thioredoxin family
DESCA_RS11385	COG1395	domain, Protein
DESCA_RS11390	COG0768	penicillin binding
DESCA_RS11395	COG0826	peptidase U32
DESCA_RS11400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DESCA_RS11410	COG1959	2 iron, 2 sulfur cluster binding
DESCA_RS11425	COG0277	FAD linked oxidase domain protein
DESCA_RS11435	COG2086	electron transfer activity
DESCA_RS11440	COG2720	vancomycin resistance protein
DESCA_RS11445	COG3906	Belongs to the UPF0473 family
DESCA_RS11450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DESCA_RS11455	COG0667	Aldo Keto reductase
DESCA_RS11460	COG4472	Bacterial protein of unknown function (DUF965)
DESCA_RS11475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DESCA_RS11480	COG0628	permease
DESCA_RS11485	COG0482	sulfurtransferase activity
DESCA_RS11490	COG0822	iron-sulfur transferase activity
DESCA_RS11500	COG1959	2 iron, 2 sulfur cluster binding
DESCA_RS11510	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DESCA_RS11515	COG3850	Histidine kinase
DESCA_RS11515	COG5002	protein histidine kinase activity
DESCA_RS11520	COG0745	RESPONSE REGULATOR receiver
DESCA_RS11525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESCA_RS11530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DESCA_RS11535	COG0124	histidyl-tRNA synthetase
DESCA_RS11560	COG5001	Diguanylate cyclase
DESCA_RS11560	COG5002	protein histidine kinase activity
DESCA_RS11585	COG1028	Short-chain dehydrogenase reductase Sdr
DESCA_RS11590	COG1309	transcriptional regulator
DESCA_RS11595	COG1511	domain protein
DESCA_RS11600	COG0531	amino acid
DESCA_RS11605	COG0622	Phosphoesterase
DESCA_RS11615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DESCA_RS11620	COG1490	D-aminoacyl-tRNA deacylase activity
DESCA_RS11630	COG0789	Transcriptional regulator
DESCA_RS11635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DESCA_RS11640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DESCA_RS11645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DESCA_RS11645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DESCA_RS11660	COG0765	amino acid transport
DESCA_RS11665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DESCA_RS11685	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DESCA_RS11690	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DESCA_RS11695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DESCA_RS11700	COG0509	glycine decarboxylation via glycine cleavage system
DESCA_RS11705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DESCA_RS11720	COG2855	membrane
DESCA_RS11725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DESCA_RS11730	COG1872	DUF167
DESCA_RS11735	COG3599	regulation of cell shape
DESCA_RS11745	COG0762	integral membrane protein
DESCA_RS11750	COG1799	cell septum assembly
DESCA_RS11755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DESCA_RS11815	COG5002	protein histidine kinase activity
DESCA_RS11820	COG0745	RESPONSE REGULATOR receiver
DESCA_RS11830	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DESCA_RS11845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DESCA_RS11850	COG1333	cytochrome c biogenesis protein
DESCA_RS11855	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
DESCA_RS11870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DESCA_RS11900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DESCA_RS11910	COG1533	DNA photolyase activity
DESCA_RS11915	COG1139	Iron-sulfur cluster binding protein
DESCA_RS11925	COG1873	PFAM PRC-barrel domain
DESCA_RS11930	COG1191	sigma factor activity
DESCA_RS11935	COG1191	sigma factor activity
DESCA_RS11950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DESCA_RS11955	COG0849	cell division
DESCA_RS11960	COG3856	small basic protein
DESCA_RS11970	COG3879	Bacterial protein of unknown function (DUF881)
DESCA_RS11980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DESCA_RS11985	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DESCA_RS11990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DESCA_RS11995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DESCA_RS12000	COG0772	Belongs to the SEDS family
DESCA_RS12005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DESCA_RS12010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DESCA_RS12015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DESCA_RS12020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DESCA_RS12025	COG0768	penicillin binding
DESCA_RS12035	COG0275	rRNA processing
DESCA_RS12040	COG2001	Belongs to the MraZ family
DESCA_RS12045	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DESCA_RS12075	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DESCA_RS12075	COG1918	ferrous iron import across plasma membrane
DESCA_RS12080	COG0735	belongs to the Fur family
DESCA_RS12085	COG1686	Belongs to the peptidase S11 family
DESCA_RS12100	COG3858	chitin binding
DESCA_RS12105	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DESCA_RS12110	COG2814	Major facilitator Superfamily
DESCA_RS12120	COG3875	lactate racemase activity
DESCA_RS12125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESCA_RS12155	COG1233	COG1233 Phytoene dehydrogenase and related
DESCA_RS12170	COG2046	Belongs to the sulfate adenylyltransferase family
DESCA_RS12175	COG2048	Heterodisulfide reductase, subunit B
DESCA_RS12195	COG0745	RESPONSE REGULATOR receiver
DESCA_RS12200	COG0697	spore germination
DESCA_RS12215	COG2720	vancomycin resistance protein
DESCA_RS12255	COG1361	Conserved repeat domain
DESCA_RS12265	COG0701	Predicted permease
DESCA_RS12270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DESCA_RS12275	COG0785	Cytochrome C biogenesis protein
DESCA_RS12305	COG1191	sigma factor activity
DESCA_RS12325	COG0745	RESPONSE REGULATOR receiver
DESCA_RS12355	COG0672	)-iron permease
DESCA_RS12400	COG0756	dUTP diphosphatase activity
DESCA_RS12430	COG0010	Belongs to the arginase family
DESCA_RS12435	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DESCA_RS12445	COG4572	Cation transport regulator
DESCA_RS12455	COG0747	negative chemotaxis
DESCA_RS12490	COG1304	FMN binding
DESCA_RS12495	COG1217	gtp-binding protein TYPA
DESCA_RS12500	COG1115	amino acid carrier protein
DESCA_RS12515	COG1950	PFAM Membrane protein of
DESCA_RS12525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DESCA_RS12565	COG3064	Membrane
DESCA_RS12565	COG0437	4 iron, 4 sulfur cluster binding
DESCA_RS12570	COG5557	Pfam Polysulphide reductase, NrfD
DESCA_RS12595	COG2814	Major facilitator Superfamily
DESCA_RS12600	COG1566	PFAM secretion protein HlyD family protein
DESCA_RS12605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESCA_RS12610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DESCA_RS12620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DESCA_RS12625	COG1121	(ABC) transporter
DESCA_RS12630	COG0803	Belongs to the bacterial solute-binding protein 9 family
DESCA_RS12640	COG0247	lactate metabolic process
DESCA_RS12645	COG2081	HI0933 family
DESCA_RS12650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DESCA_RS12665	COG3328	transposase activity
DESCA_RS12675	COG0861	Integral membrane protein TerC family
DESCA_RS12680	COG0517	IMP dehydrogenase activity
DESCA_RS12685	COG0688	phosphatidylethanolamine metabolic process
DESCA_RS12695	COG0531	amino acid
DESCA_RS12710	COG0514	ATP-dependent DNA helicase (RecQ)
DESCA_RS12735	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DESCA_RS12745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DESCA_RS12750	COG0251	oxidation-reduction process
DESCA_RS12795	COG3829	transcription factor binding
DESCA_RS12810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DESCA_RS12825	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DESCA_RS12830	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DESCA_RS12835	COG0148	phosphopyruvate hydratase activity
DESCA_RS12840	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DESCA_RS12845	COG0149	triose-phosphate isomerase activity
DESCA_RS12850	COG0126	phosphoglycerate kinase activity
DESCA_RS12860	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DESCA_RS12870	COG0110	maltose O-acetyltransferase activity
DESCA_RS12880	COG1481	regulation of sporulation
DESCA_RS12885	COG0726	polysaccharide deacetylase
DESCA_RS12890	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DESCA_RS12895	COG1660	Displays ATPase and GTPase activities
DESCA_RS12900	COG1940	carbohydrate kinase activity
DESCA_RS12910	COG0561	phosphatase activity
DESCA_RS12915	COG0322	excinuclease ABC activity
DESCA_RS12920	COG1309	transcriptional regulator
DESCA_RS12925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DESCA_RS12930	COG1136	(ABC) transporter
DESCA_RS12945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DESCA_RS12950	COG0556	nucleotide-excision repair
DESCA_RS12980	COG0697	spore germination
DESCA_RS12985	COG0697	spore germination
DESCA_RS12990	COG1573	uracil-dna glycosylase
DESCA_RS13010	COG0793	Belongs to the peptidase S41A family
DESCA_RS13010	COG3409	Peptidoglycan-binding domain 1 protein
DESCA_RS13015	COG0739	heme binding
DESCA_RS13020	COG2177	Part of the ABC transporter FtsEX involved in
DESCA_RS13025	COG2884	Cell division ATP-binding protein ftsE
DESCA_RS13040	COG3958	Transketolase
DESCA_RS13045	COG3959	Transketolase, thiamine diphosphate binding domain
DESCA_RS13050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DESCA_RS13055	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DESCA_RS13060	COG0653	protein targeting
DESCA_RS13095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DESCA_RS13100	COG1278	Cold shock
DESCA_RS13105	COG1040	competence protein
DESCA_RS13140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DESCA_RS13160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DESCA_RS13170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DESCA_RS13175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DESCA_RS13180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DESCA_RS13185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DESCA_RS13230	COG1316	TRANSCRIPTIONal
DESCA_RS13380	COG1091	dTDP-4-dehydrorhamnose reductase activity
DESCA_RS13415	COG1077	Cell shape determining protein MreB Mrl
DESCA_RS13420	COG1609	Transcriptional regulator
DESCA_RS13435	COG2385	sporulation resulting in formation of a cellular spore
DESCA_RS13440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DESCA_RS13445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DESCA_RS13450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DESCA_RS13455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DESCA_RS13460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DESCA_RS13465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DESCA_RS13470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DESCA_RS13475	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DESCA_RS13480	COG0356	it plays a direct role in the translocation of protons across the membrane
DESCA_RS13495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DESCA_RS13510	COG2131	deaminase
DESCA_RS13515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DESCA_RS13525	COG0698	ribose 5-phosphate isomerase
DESCA_RS13530	COG1971	Probably functions as a manganese efflux pump
DESCA_RS13535	COG0009	L-threonylcarbamoyladenylate synthase
DESCA_RS13540	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
DESCA_RS13550	COG2890	protein-(glutamine-N5) methyltransferase activity
DESCA_RS13555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DESCA_RS13560	COG3872	metal-dependent enzyme
DESCA_RS13565	COG0254	rRNA binding
DESCA_RS13570	COG5632	N-Acetylmuramoyl-L-alanine amidase
DESCA_RS13570	COG3409	Peptidoglycan-binding domain 1 protein
DESCA_RS13575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DESCA_RS13585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DESCA_RS13600	COG2204	response regulator
DESCA_RS13610	COG0616	signal peptide processing
DESCA_RS13615	COG0504	CTP synthase activity
DESCA_RS13625	COG0018	arginyl-trna synthetase
DESCA_RS13640	COG2221	Nitrite and sulphite reductase 4Fe-4S
DESCA_RS13645	COG2221	Nitrite and sulphite reductase 4Fe-4S
DESCA_RS13665	COG4145	pantothenate transmembrane transporter activity
DESCA_RS13670	COG0436	Aminotransferase
DESCA_RS13675	COG1522	sequence-specific DNA binding
DESCA_RS13680	COG2959	enzyme of heme biosynthesis
DESCA_RS13690	COG1797	cobyrinic acid a,c-diamide synthase activity
DESCA_RS13695	COG2920	part of a sulfur-relay system
DESCA_RS13700	COG0247	lactate metabolic process
DESCA_RS13705	COG2181	nitrate reductase activity
DESCA_RS13730	COG2358	TRAP transporter, solute receptor (TAXI family
DESCA_RS13745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DESCA_RS13745	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DESCA_RS13750	COG1115	amino acid carrier protein
DESCA_RS13760	COG2816	NAD+ diphosphatase activity
DESCA_RS13770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DESCA_RS13770	COG2199	diguanylate cyclase activity
DESCA_RS13790	COG2200	EAL domain
DESCA_RS13795	COG1115	amino acid carrier protein
DESCA_RS13800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DESCA_RS13805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DESCA_RS13810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DESCA_RS13810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DESCA_RS13810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DESCA_RS13820	COG1105	Belongs to the carbohydrate kinase PfkB family
DESCA_RS13825	COG1349	DNA-binding transcription factor activity
DESCA_RS13830	COG0432	Pfam Uncharacterised protein family UPF0047
DESCA_RS13840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DESCA_RS13840	COG0519	Catalyzes the synthesis of GMP from XMP
DESCA_RS13845	COG0778	Nitroreductase
DESCA_RS13855	COG0640	Transcriptional regulator
DESCA_RS13865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DESCA_RS13870	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DESCA_RS13875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DESCA_RS13890	COG0739	heme binding
DESCA_RS13915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DESCA_RS13920	COG0305	Participates in initiation and elongation during chromosome replication
DESCA_RS13925	COG1067	ATP-dependent peptidase activity
DESCA_RS13925	COG0470	DNA polymerase III
DESCA_RS13930	COG0359	binds to the 23S rRNA
DESCA_RS13940	COG2814	Major facilitator Superfamily
DESCA_RS13945	COG1846	Transcriptional regulator
DESCA_RS13950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DESCA_RS13955	COG0629	single-stranded DNA binding
DESCA_RS13960	COG0360	Binds together with S18 to 16S ribosomal RNA
DESCA_RS13965	COG4481	Protein conserved in bacteria
DESCA_RS13970	COG0668	transmembrane transport
DESCA_RS13975	COG1362	aminopeptidase activity
DESCA_RS13985	COG3949	Membrane
DESCA_RS14010	COG1811	Na channel or pump
DESCA_RS14015	COG1475	DNA binding
DESCA_RS14020	COG1192	Involved in chromosome partitioning
DESCA_RS14025	COG0357	Ribosomal RNA small subunit methyltransferase G
DESCA_RS14030	COG0445	tRNA wobble uridine modification
DESCA_RS14035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DESCA_RS14040	COG1847	R3H domain protein
DESCA_RS14055	COG0706	membrane insertase activity
DESCA_RS14060	COG0594	ribonuclease P activity
DESCA_RS14075	COG3852	Histidine kinase
DESCA_RS14090	COG1595	DNA-templated transcription, initiation
DESCA_RS14105	COG3437	response regulator, receiver
DESCA_RS14120	COG1216	Glycosyl transferase, family 2
DESCA_RS14125	COG5002	protein histidine kinase activity
DESCA_RS14155	COG1012	belongs to the aldehyde dehydrogenase family
DESCA_RS14160	COG1012	belongs to the aldehyde dehydrogenase family
DESCA_RS14175	COG1454	alcohol dehydrogenase
DESCA_RS14190	COG1376	ErfK ybiS ycfS ynhG family protein
DESCA_RS14210	COG0438	transferase activity, transferring glycosyl groups