locus-tag	class	description
E8L03_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E8L03_RS00020	COG4191	Histidine kinase
E8L03_RS00025	COG2873	o-acetylhomoserine
E8L03_RS00030	COG1278	Cold shock
E8L03_RS00060	COG3260	NADH ubiquinone oxidoreductase 20
E8L03_RS00065	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E8L03_RS00070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E8L03_RS00070	COG2111	Na H antiporter
E8L03_RS00090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E8L03_RS00105	COG0573	inorganic phosphate transmembrane transporter activity
E8L03_RS00110	COG0670	Belongs to the BI1 family
E8L03_RS00115	COG0557	exoribonuclease II activity
E8L03_RS00120	COG0438	transferase activity, transferring glycosyl groups
E8L03_RS00145	COG1088	dTDP-glucose 4,6-dehydratase activity
E8L03_RS00165	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E8L03_RS00170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E8L03_RS00175	COG0129	dihydroxy-acid dehydratase activity
E8L03_RS00190	COG1304	FMN binding
E8L03_RS00195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E8L03_RS00210	COG0569	domain protein
E8L03_RS00215	COG0569	domain protein
E8L03_RS00215	COG0475	glutathione-regulated potassium exporter activity
E8L03_RS00260	COG0714	Associated with various cellular activities
E8L03_RS00295	COG0784	Response regulator, receiver
E8L03_RS00295	COG2205	protein histidine kinase activity
E8L03_RS00300	COG1881	PFAM PEBP family protein
E8L03_RS00305	COG4822	anaerobic cobalamin biosynthetic process
E8L03_RS00315	COG2205	protein histidine kinase activity
E8L03_RS00315	COG0784	Response regulator, receiver
E8L03_RS00365	COG1760	l-serine dehydratase
E8L03_RS00370	COG4957	zinc ion binding
E8L03_RS00375	COG4957	zinc ion binding
E8L03_RS00395	COG1716	ATPase activity
E8L03_RS00395	COG0842	Transport permease protein
E8L03_RS00395	COG1131	(ABC) transporter
E8L03_RS00455	COG2943	transferase activity, transferring hexosyl groups
E8L03_RS00460	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E8L03_RS00475	COG3852	Histidine kinase
E8L03_RS00480	COG0747	negative chemotaxis
E8L03_RS00520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E8L03_RS00525	COG0569	domain protein
E8L03_RS00530	COG1309	transcriptional regulator
E8L03_RS00550	COG2770	Histidine kinase
E8L03_RS00550	COG3437	response regulator, receiver
E8L03_RS00585	COG1136	(ABC) transporter
E8L03_RS00590	COG0577	efflux transmembrane transporter activity
E8L03_RS00610	COG0438	transferase activity, transferring glycosyl groups
E8L03_RS00615	COG0438	transferase activity, transferring glycosyl groups
E8L03_RS00625	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E8L03_RS00655	COG5001	Diguanylate cyclase
E8L03_RS00655	COG3706	GGDEF domain
E8L03_RS00655	COG2203	Gaf domain
E8L03_RS00655	COG4251	negative regulation of phosphorylation
E8L03_RS00670	COG1127	ABC transporter
E8L03_RS00675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E8L03_RS00705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E8L03_RS00710	COG1945	arginine decarboxylase activity
E8L03_RS00725	COG0018	arginyl-trna synthetase
E8L03_RS00730	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E8L03_RS00745	COG1017	nitric oxide dioxygenase activity
E8L03_RS00745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E8L03_RS00755	COG1287	oligosaccharyl transferase activity
E8L03_RS00755	COG1287	oligosaccharyl transferase activity
E8L03_RS00760	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E8L03_RS00780	COG0297	glycogen (starch) synthase activity
E8L03_RS00785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E8L03_RS00795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E8L03_RS00815	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E8L03_RS00820	COG0742	ribosomal rna small subunit methyltransferase
E8L03_RS00830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E8L03_RS00835	COG2385	sporulation resulting in formation of a cellular spore
E8L03_RS00840	COG1774	PSP1 C-terminal conserved region
E8L03_RS00845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8L03_RS00845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8L03_RS00855	COG3949	Membrane
E8L03_RS00875	COG3829	transcription factor binding
E8L03_RS00905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8L03_RS00910	COG1414	Transcriptional regulator
E8L03_RS00915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8L03_RS00925	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8L03_RS00935	COG2721	sulfolactate sulfo-lyase activity
E8L03_RS01005	COG2181	nitrate reductase activity
E8L03_RS01005	COG0247	lactate metabolic process
E8L03_RS01010	COG2181	nitrate reductase activity
E8L03_RS01010	COG0247	lactate metabolic process
E8L03_RS01030	COG1131	(ABC) transporter
E8L03_RS01070	COG1966	Carbon starvation protein
E8L03_RS01075	COG3275	phosphorelay sensor kinase activity
E8L03_RS01080	COG3279	Response regulator of the LytR AlgR family
E8L03_RS01115	COG0651	ATP synthesis coupled electron transport
E8L03_RS01120	COG0651	ATP synthesis coupled electron transport
E8L03_RS01125	COG1006	Multisubunit Na H antiporter MnhC subunit
E8L03_RS01160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E8L03_RS01195	COG1215	transferase activity, transferring glycosyl groups
E8L03_RS01205	COG0463	Glycosyl transferase, family 2
E8L03_RS01205	COG1216	Glycosyl transferase, family 2
E8L03_RS01210	COG0297	glycogen (starch) synthase activity
E8L03_RS01215	COG1216	Glycosyl transferase, family 2
E8L03_RS01220	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E8L03_RS01225	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E8L03_RS01225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E8L03_RS01250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E8L03_RS01260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E8L03_RS01275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E8L03_RS01280	COG3959	Transketolase, thiamine diphosphate binding domain
E8L03_RS01285	COG1088	dTDP-glucose 4,6-dehydratase activity
E8L03_RS01295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E8L03_RS01315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E8L03_RS01320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E8L03_RS01330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E8L03_RS01335	COG0049	tRNA binding
E8L03_RS01340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E8L03_RS01345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E8L03_RS01355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E8L03_RS01360	COG0088	Forms part of the polypeptide exit tunnel
E8L03_RS01365	COG0089	rRNA binding
E8L03_RS01375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E8L03_RS01380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E8L03_RS01385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E8L03_RS01390	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E8L03_RS01395	COG0255	Belongs to the universal ribosomal protein uL29 family
E8L03_RS01400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E8L03_RS01405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E8L03_RS01415	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E8L03_RS01420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E8L03_RS01425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E8L03_RS01430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E8L03_RS01435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E8L03_RS01440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E8L03_RS01445	COG1841	ribosomal large subunit assembly
E8L03_RS01450	COG0200	Binds to the 23S rRNA
E8L03_RS01470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E8L03_RS01480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E8L03_RS01490	COG0203	ribosomal protein L17
E8L03_RS01495	COG0583	DNA-binding transcription factor activity
E8L03_RS01540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E8L03_RS01555	COG1355	regulation of microtubule-based process
E8L03_RS01565	COG3976	FMN-binding domain protein
E8L03_RS01565	COG1053	succinate dehydrogenase
E8L03_RS01580	COG3180	Ammonia monooxygenase
E8L03_RS01595	COG1215	transferase activity, transferring glycosyl groups
E8L03_RS01615	COG5002	protein histidine kinase activity
E8L03_RS01620	COG2205	protein histidine kinase activity
E8L03_RS01620	COG0784	Response regulator, receiver
E8L03_RS01630	COG3267	Type II secretory pathway component ExeA
E8L03_RS01630	COG3409	Peptidoglycan-binding domain 1 protein
E8L03_RS01660	COG1696	Membrane protein involved in D-alanine export
E8L03_RS01670	COG0438	transferase activity, transferring glycosyl groups
E8L03_RS01715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E8L03_RS01730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8L03_RS01740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E8L03_RS01740	COG2010	Cytochrome c
E8L03_RS01745	COG2814	Major facilitator Superfamily
E8L03_RS01770	COG1032	radical SAM domain protein
E8L03_RS01785	COG3944	biosynthesis protein
E8L03_RS01790	COG3267	Type II secretory pathway component ExeA
E8L03_RS01790	COG3409	Peptidoglycan-binding domain 1 protein
E8L03_RS01820	COG0726	polysaccharide deacetylase
E8L03_RS01835	COG1215	transferase activity, transferring glycosyl groups
E8L03_RS01840	COG1216	Glycosyl transferase, family 2
E8L03_RS01875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E8L03_RS01875	COG0425	Belongs to the sulfur carrier protein TusA family
E8L03_RS01890	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8L03_RS01915	COG2210	Belongs to the sulfur carrier protein TusA family
E8L03_RS01925	COG0778	Nitroreductase
E8L03_RS01975	COG2207	Transcriptional regulator
E8L03_RS01995	COG1528	Iron-storage protein
E8L03_RS02010	COG1013	pyruvate-flavodoxin oxidoreductase activity
E8L03_RS02030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E8L03_RS02035	COG0659	secondary active sulfate transmembrane transporter activity
E8L03_RS02045	COG1013	pyruvate-flavodoxin oxidoreductase activity
E8L03_RS02050	COG0674	pyruvate-flavodoxin oxidoreductase activity
E8L03_RS02050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E8L03_RS02070	COG0564	pseudouridine synthase activity
E8L03_RS02075	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E8L03_RS02080	COG2233	PERMEase
E8L03_RS02090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E8L03_RS02100	COG0131	Imidazoleglycerol-phosphate dehydratase
E8L03_RS02120	COG1051	belongs to the nudix hydrolase family
E8L03_RS02135	COG0840	transmembrane signaling receptor activity
E8L03_RS02155	COG4176	ABC-type proline glycine betaine transport system permease component
E8L03_RS02165	COG4134	Bacterial extracellular solute-binding protein
E8L03_RS02170	COG3842	ATPase activity
E8L03_RS02180	COG0310	cobalt ion transport
E8L03_RS02185	COG0310	cobalt ion transport
E8L03_RS02185	COG0310	cobalt ion transport
E8L03_RS02195	COG0038	chloride channel
E8L03_RS02210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E8L03_RS02220	COG0588	phosphoglycerate mutase activity
E8L03_RS02240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E8L03_RS02245	COG5002	protein histidine kinase activity
E8L03_RS02250	COG0745	RESPONSE REGULATOR receiver
E8L03_RS02260	COG2205	protein histidine kinase activity
E8L03_RS02285	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8L03_RS02305	COG4232	protein-disulfide reductase activity
E8L03_RS02310	COG3706	GGDEF domain
E8L03_RS02320	COG1832	CoA-binding protein
E8L03_RS02330	COG0484	heat shock protein binding
E8L03_RS02355	COG0719	Fe-S assembly protein
E8L03_RS02360	COG0396	ATPase activity
E8L03_RS02370	COG1408	metallophosphoesterase
E8L03_RS02380	COG2962	Rard protein
E8L03_RS02385	COG1335	isochorismatase
E8L03_RS02395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E8L03_RS02420	COG0791	NLP P60 protein
E8L03_RS02425	COG2132	Multicopper oxidase
E8L03_RS02460	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E8L03_RS02465	COG2801	Transposase and inactivated derivatives
E8L03_RS02500	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E8L03_RS02505	COG0442	prolyl-tRNA aminoacylation
E8L03_RS02520	COG1722	exodeoxyribonuclease VII activity
E8L03_RS02530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E8L03_RS02535	COG0318	PFAM AMP-dependent synthetase and ligase
E8L03_RS02540	COG0584	glycerophosphoryl diester phosphodiesterase
E8L03_RS02545	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E8L03_RS02550	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E8L03_RS02560	COG0799	negative regulation of ribosome biogenesis
E8L03_RS02565	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E8L03_RS02610	COG0681	Belongs to the peptidase S26 family
E8L03_RS02615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E8L03_RS02650	COG0028	Belongs to the TPP enzyme family
E8L03_RS02655	COG0440	acetolactate synthase activity
E8L03_RS02660	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E8L03_RS02695	COG2358	TRAP transporter, solute receptor (TAXI family
E8L03_RS02700	COG0405	Gamma-glutamyltransferase
E8L03_RS02705	COG0840	transmembrane signaling receptor activity
E8L03_RS02710	COG0745	RESPONSE REGULATOR receiver
E8L03_RS02735	COG0840	transmembrane signaling receptor activity
E8L03_RS02755	COG0640	Transcriptional regulator
E8L03_RS02765	COG1141	Ferredoxin
E8L03_RS02770	COG0243	molybdopterin cofactor binding
E8L03_RS02780	COG3842	ATPase activity
E8L03_RS02785	COG3842	ATPase activity
E8L03_RS02790	COG0395	ABC-type sugar transport system, permease component
E8L03_RS02795	COG1175	transmembrane transport
E8L03_RS02820	COG2204	response regulator
E8L03_RS02825	COG1970	mechanosensitive ion channel activity
E8L03_RS02855	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E8L03_RS02880	COG2204	response regulator
E8L03_RS02890	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E8L03_RS02895	COG4778	phosphonate C-P lyase system protein PhnL
E8L03_RS02900	COG4107	phosphonate C-P lyase system protein PhnK
E8L03_RS02905	COG3627	carbon phosphorus lyase activity
E8L03_RS02910	COG3626	phosphonate metabolism
E8L03_RS02920	COG3624	Phosphonate C-P lyase system protein PhnG
E8L03_RS02925	COG2188	Transcriptional regulator
E8L03_RS02930	COG3454	Phosphonate metabolism
E8L03_RS02935	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E8L03_RS02940	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E8L03_RS02945	COG3639	organic phosphonate transmembrane transporter activity
E8L03_RS02950	COG3639	organic phosphonate transmembrane transporter activity
E8L03_RS02960	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E8L03_RS02965	COG3454	Phosphonate metabolism
E8L03_RS02975	COG0784	Response regulator, receiver
E8L03_RS02975	COG2198	Histidine kinase
E8L03_RS02975	COG2205	protein histidine kinase activity
E8L03_RS02980	COG1216	Glycosyl transferase, family 2
E8L03_RS02980	COG0463	Glycosyl transferase, family 2
E8L03_RS02990	COG0438	transferase activity, transferring glycosyl groups
E8L03_RS03010	COG0463	Glycosyl transferase, family 2
E8L03_RS03020	COG0438	transferase activity, transferring glycosyl groups
E8L03_RS03040	COG3267	Type II secretory pathway component ExeA
E8L03_RS03040	COG3409	Peptidoglycan-binding domain 1 protein
E8L03_RS03045	COG0489	protein tyrosine kinase activity
E8L03_RS03055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E8L03_RS03105	COG2204	response regulator
E8L03_RS03140	COG1309	transcriptional regulator
E8L03_RS03150	COG0673	inositol 2-dehydrogenase activity
E8L03_RS03175	COG1882	Formate acetyltransferase
E8L03_RS03185	COG3829	transcription factor binding
E8L03_RS03185	COG3290	protein histidine kinase activity
E8L03_RS03190	COG1178	ABC-type Fe3 transport system permease component
E8L03_RS03195	COG3842	ATPase activity
E8L03_RS03200	COG1840	ABC-type Fe3 transport system, periplasmic component
E8L03_RS03215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E8L03_RS03235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E8L03_RS03250	COG3875	lactate racemase activity
E8L03_RS03255	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E8L03_RS03290	COG2274	protein secretion by the type I secretion system
E8L03_RS03340	COG1857	crispr-associated protein
E8L03_RS03355	COG1518	maintenance of DNA repeat elements
E8L03_RS03360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E8L03_RS03405	COG0047	phosphoribosylformylglycinamidine synthase activity
E8L03_RS03405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E8L03_RS03415	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E8L03_RS03425	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E8L03_RS03430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8L03_RS03435	COG1660	Displays ATPase and GTPase activities
E8L03_RS03455	COG1227	inorganic diphosphatase activity
E8L03_RS03460	COG3706	GGDEF domain
E8L03_RS03470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E8L03_RS03495	COG3706	GGDEF domain
E8L03_RS03505	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E8L03_RS03510	COG4535	Mg2 and Co2 transporter CorC
E8L03_RS03520	COG0445	tRNA wobble uridine modification
E8L03_RS03525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E8L03_RS03540	COG0402	S-adenosylhomocysteine deaminase activity
E8L03_RS03545	COG0402	S-adenosylhomocysteine deaminase activity
E8L03_RS03550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E8L03_RS03560	COG1862	Preprotein translocase
E8L03_RS03565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E8L03_RS03570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E8L03_RS03580	COG1741	Belongs to the pirin family
E8L03_RS03610	COG2239	Acts as a magnesium transporter
E8L03_RS03615	COG3852	Histidine kinase
E8L03_RS03625	COG3237	CsbD-like
E8L03_RS03710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E8L03_RS03750	COG1968	undecaprenyl-diphosphatase activity
E8L03_RS03760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E8L03_RS03770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E8L03_RS03775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E8L03_RS03780	COG1674	ftsk spoiiie
E8L03_RS03800	COG1187	pseudouridine synthase activity
E8L03_RS03805	COG0425	Belongs to the sulfur carrier protein TusA family
E8L03_RS03835	COG0436	Aminotransferase
E8L03_RS03845	COG3620	sequence-specific DNA binding
E8L03_RS03845	COG0617	tRNA 3'-terminal CCA addition
E8L03_RS03845	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E8L03_RS03850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E8L03_RS03875	COG0019	diaminopimelate decarboxylase activity
E8L03_RS03905	COG0149	triose-phosphate isomerase activity
E8L03_RS03920	COG0483	inositol monophosphate 1-phosphatase activity
E8L03_RS03940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E8L03_RS03945	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E8L03_RS03965	COG4953	penicillin-binding protein 1C
E8L03_RS03970	COG2373	Large extracellular alpha-helical protein
E8L03_RS03975	COG0739	heme binding
E8L03_RS03975	COG1196	nuclear chromosome segregation
E8L03_RS03975	COG0741	lytic transglycosylase activity
E8L03_RS03985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8L03_RS04000	COG0438	transferase activity, transferring glycosyl groups
E8L03_RS04010	COG2801	Transposase and inactivated derivatives
E8L03_RS04015	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E8L03_RS04025	COG3273	potassium ion transport
E8L03_RS04025	COG0471	metal ion transport
E8L03_RS04040	COG0515	serine threonine protein kinase
E8L03_RS04040	COG2815	serine threonine protein kinase
E8L03_RS04055	COG0656	L-ascorbic acid biosynthetic process
E8L03_RS04075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E8L03_RS04105	COG1215	transferase activity, transferring glycosyl groups
E8L03_RS04120	COG0730	response to heat
E8L03_RS04130	COG2186	Transcriptional regulator
E8L03_RS04135	COG2203	Gaf domain
E8L03_RS04135	COG3706	GGDEF domain
E8L03_RS04135	COG4251	negative regulation of phosphorylation
E8L03_RS04135	COG5001	Diguanylate cyclase
E8L03_RS04145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E8L03_RS04150	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E8L03_RS04155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E8L03_RS04175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E8L03_RS04180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E8L03_RS04195	COG0456	acetyltransferase
E8L03_RS04235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E8L03_RS04250	COG0037	tRNA processing
E8L03_RS04255	COG0563	adenylate kinase activity
E8L03_RS04275	COG0569	domain protein
E8L03_RS04280	COG0268	Binds directly to 16S ribosomal RNA
E8L03_RS04285	COG0751	glycine-tRNA ligase activity
E8L03_RS04290	COG0752	glycyl-tRNA synthetase alpha subunit
E8L03_RS04295	COG1381	Involved in DNA repair and RecF pathway recombination
E8L03_RS04300	COG1426	Protein conserved in bacteria
E8L03_RS04305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E8L03_RS04320	COG0835	chemotaxis
E8L03_RS04335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E8L03_RS04340	COG0736	holo-[acyl-carrier-protein] synthase activity
E8L03_RS04345	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E8L03_RS04345	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E8L03_RS04355	COG0802	atpase or kinase
E8L03_RS04360	COG0527	aspartate kinase activity
E8L03_RS04365	COG2198	Histidine kinase
E8L03_RS04365	COG2205	protein histidine kinase activity
E8L03_RS04365	COG0784	Response regulator, receiver
E8L03_RS04390	COG0358	DNA primase activity
E8L03_RS04395	COG1193	negative regulation of DNA recombination
E8L03_RS04405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E8L03_RS04420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E8L03_RS04440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E8L03_RS04450	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E8L03_RS04455	COG0492	ferredoxin-NADP+ reductase activity
E8L03_RS04460	COG3118	belongs to the thioredoxin family
E8L03_RS04495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E8L03_RS04500	COG0741	lytic transglycosylase activity
E8L03_RS04505	COG0489	protein tyrosine kinase activity
E8L03_RS04510	COG1238	metal cluster binding
E8L03_RS04515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E8L03_RS04520	COG0517	IMP dehydrogenase activity
E8L03_RS04540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E8L03_RS04540	COG0574	Belongs to the PEP-utilizing enzyme family
E8L03_RS04545	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E8L03_RS04560	COG1073	alpha beta
E8L03_RS04570	COG0215	cysteine-tRNA ligase activity
E8L03_RS04575	COG4783	chaperone-mediated protein folding
E8L03_RS04585	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E8L03_RS04590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E8L03_RS04600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E8L03_RS04605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E8L03_RS04610	COG0193	aminoacyl-tRNA hydrolase activity
E8L03_RS04635	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E8L03_RS04650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8L03_RS04655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E8L03_RS04660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E8L03_RS04675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E8L03_RS04700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E8L03_RS04740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E8L03_RS04780	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E8L03_RS04790	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E8L03_RS04800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E8L03_RS04805	COG1993	acr, cog1993
E8L03_RS04810	COG2201	protein-glutamate methylesterase activity
E8L03_RS04820	COG2198	Histidine kinase
E8L03_RS04820	COG0643	Histidine kinase
E8L03_RS04825	COG0745	RESPONSE REGULATOR receiver
E8L03_RS04835	COG0840	transmembrane signaling receptor activity
E8L03_RS04840	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E8L03_RS04860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E8L03_RS04865	COG0646	methionine synthase
E8L03_RS04865	COG1410	methionine synthase
E8L03_RS04885	COG0698	ribose 5-phosphate isomerase
E8L03_RS04890	COG1494	fructose-1,6-bisphosphatase
E8L03_RS04915	COG2095	MarC family integral membrane protein
E8L03_RS04945	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E8L03_RS04965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E8L03_RS04965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E8L03_RS05005	COG1959	2 iron, 2 sulfur cluster binding
E8L03_RS05010	COG2204	response regulator
E8L03_RS05015	COG2204	response regulator
E8L03_RS05020	COG2204	response regulator
E8L03_RS05030	COG0247	lactate metabolic process
E8L03_RS05035	COG2181	nitrate reductase activity
E8L03_RS05045	COG5557	Pfam Polysulphide reductase, NrfD
E8L03_RS05050	COG0437	4 iron, 4 sulfur cluster binding
E8L03_RS05050	COG3064	Membrane
E8L03_RS05055	COG0484	heat shock protein binding
E8L03_RS05100	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E8L03_RS05105	COG0667	Aldo Keto reductase
E8L03_RS05115	COG3387	PFAM Glycoside hydrolase 15-related
E8L03_RS05120	COG0655	NAD(P)H dehydrogenase (quinone) activity
E8L03_RS05140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E8L03_RS05160	COG0402	S-adenosylhomocysteine deaminase activity
E8L03_RS05180	COG3527	Alpha-acetolactate decarboxylase
E8L03_RS05185	COG0513	Belongs to the DEAD box helicase family
E8L03_RS05190	COG3842	ATPase activity
E8L03_RS05210	COG1131	(ABC) transporter
E8L03_RS05215	COG0842	Transport permease protein
E8L03_RS05225	COG0463	Glycosyl transferase, family 2
E8L03_RS05240	COG0438	transferase activity, transferring glycosyl groups
E8L03_RS05315	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E8L03_RS05320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E8L03_RS05325	COG0497	DNA recombination
E8L03_RS05330	COG4969	Belongs to the N-Me-Phe pilin family
E8L03_RS05350	COG3267	Type II secretory pathway component ExeA
E8L03_RS05350	COG3409	Peptidoglycan-binding domain 1 protein
E8L03_RS05355	COG4796	Type ii and iii secretion system protein
E8L03_RS05400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E8L03_RS05405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E8L03_RS05430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E8L03_RS05435	COG2814	Major facilitator Superfamily
E8L03_RS05450	COG1252	NADH dehydrogenase
E8L03_RS05460	COG0629	single-stranded DNA binding
E8L03_RS05475	COG0825	malonyl-CoA metabolic process
E8L03_RS05480	COG0439	Biotin carboxylase
E8L03_RS05495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E8L03_RS05500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E8L03_RS05520	COG1215	transferase activity, transferring glycosyl groups
E8L03_RS05555	COG0577	efflux transmembrane transporter activity
E8L03_RS05560	COG0156	8-amino-7-oxononanoate synthase activity
E8L03_RS05575	COG0297	glycogen (starch) synthase activity
E8L03_RS05585	COG1063	alcohol dehydrogenase
E8L03_RS05620	COG4172	Belongs to the ABC transporter superfamily
E8L03_RS05625	COG4239	(ABC) transporter, permease
E8L03_RS05630	COG4174	ABC transporter (Permease)
E8L03_RS05635	COG4166	transmembrane transport
E8L03_RS05645	COG0583	DNA-binding transcription factor activity
E8L03_RS05665	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E8L03_RS05670	COG3481	metal-dependent phosphohydrolase, HD sub domain
E8L03_RS05675	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E8L03_RS05700	COG1104	cysteine desulfurase activity
E8L03_RS05705	COG1253	flavin adenine dinucleotide binding
E8L03_RS05715	COG1138	Cytochrome C-type biogenesis protein
E8L03_RS05730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E8L03_RS05770	COG0516	GMP reductase activity
E8L03_RS05770	COG0517	IMP dehydrogenase activity
E8L03_RS05780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E8L03_RS05785	COG0805	protein transport
E8L03_RS05790	COG0205	6-phosphofructokinase activity
E8L03_RS05835	COG4974	Belongs to the 'phage' integrase family
E8L03_RS05840	COG3706	GGDEF domain
E8L03_RS05855	COG0758	DNA mediated transformation
E8L03_RS05875	COG2198	Histidine kinase
E8L03_RS05875	COG0784	Response regulator, receiver
E8L03_RS05875	COG0643	Histidine kinase
E8L03_RS05875	COG2198	Histidine kinase
E8L03_RS05875	COG0784	Response regulator, receiver
E8L03_RS05875	COG0643	Histidine kinase
E8L03_RS05880	COG0745	RESPONSE REGULATOR receiver
E8L03_RS05885	COG0835	chemotaxis
E8L03_RS05890	COG1192	Involved in chromosome partitioning
E8L03_RS05895	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E8L03_RS05905	COG2201	protein-glutamate methylesterase activity
E8L03_RS05920	COG4977	sequence-specific DNA binding
E8L03_RS05925	COG0840	transmembrane signaling receptor activity
E8L03_RS05935	COG0297	glycogen (starch) synthase activity
E8L03_RS05940	COG0589	response to stress
E8L03_RS05955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E8L03_RS05960	COG0701	Predicted permease
E8L03_RS06005	COG0784	Response regulator, receiver
E8L03_RS06005	COG4191	Histidine kinase
E8L03_RS06055	COG2226	methyltransferase
E8L03_RS06080	COG0745	RESPONSE REGULATOR receiver
E8L03_RS06085	COG0509	glycine decarboxylation via glycine cleavage system
E8L03_RS06090	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E8L03_RS06095	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E8L03_RS06100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E8L03_RS06115	COG0450	alkyl hydroperoxide reductase
E8L03_RS06125	COG0628	permease
E8L03_RS06130	COG1785	Belongs to the alkaline phosphatase family
E8L03_RS06150	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E8L03_RS06160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E8L03_RS06165	COG0105	UTP biosynthetic process
E8L03_RS06170	COG2861	carbohydrate metabolic process
E8L03_RS06175	COG0793	Belongs to the peptidase S41A family
E8L03_RS06190	COG2264	protein methyltransferase activity
E8L03_RS06195	COG0765	amino acid transport
E8L03_RS06200	COG0765	amino acid transport
E8L03_RS06205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8L03_RS06225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E8L03_RS06240	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E8L03_RS06275	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E8L03_RS06280	COG5002	protein histidine kinase activity
E8L03_RS06285	COG0745	RESPONSE REGULATOR receiver
E8L03_RS06300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E8L03_RS06305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E8L03_RS06310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E8L03_RS06320	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E8L03_RS06325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E8L03_RS06330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E8L03_RS06340	COG0165	Argininosuccinate lyase
E8L03_RS06345	COG0137	argininosuccinate synthase activity
E8L03_RS06350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E8L03_RS06355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E8L03_RS06370	COG0745	RESPONSE REGULATOR receiver
E8L03_RS06375	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E8L03_RS06380	COG1480	7TM receptor with intracellular HD hydrolase
E8L03_RS06385	COG1702	phosphate starvation-inducible protein PhoH
E8L03_RS06415	COG0243	molybdopterin cofactor binding
E8L03_RS06420	COG1140	nitrate reductase beta subunit
E8L03_RS06460	COG0464	growth
E8L03_RS06460	COG0457	Tetratricopeptide repeat
E8L03_RS06465	COG2920	part of a sulfur-relay system
E8L03_RS06470	COG1250	3-hydroxyacyl-CoA dehydrogenase
E8L03_RS06495	COG0840	transmembrane signaling receptor activity
E8L03_RS06535	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E8L03_RS06540	COG0352	thiamine-phosphate diphosphorylase activity
E8L03_RS06550	COG0542	response to heat
E8L03_RS06565	COG1012	belongs to the aldehyde dehydrogenase family
E8L03_RS06610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E8L03_RS06620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E8L03_RS06630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E8L03_RS06640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E8L03_RS06645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E8L03_RS06655	COG2131	deaminase
E8L03_RS06660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E8L03_RS06660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E8L03_RS06670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E8L03_RS06670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E8L03_RS06675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E8L03_RS06700	COG2003	Belongs to the UPF0758 family
E8L03_RS06705	COG1254	Belongs to the acylphosphatase family
E8L03_RS06710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E8L03_RS06735	COG2204	response regulator
E8L03_RS06740	COG4191	Histidine kinase
E8L03_RS06760	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
E8L03_RS06765	COG4336	lyase activity
E8L03_RS06775	COG1573	uracil-dna glycosylase
E8L03_RS06800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E8L03_RS06805	COG3300	MHYT domain
E8L03_RS06805	COG5001	Diguanylate cyclase
E8L03_RS06840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E8L03_RS06855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E8L03_RS06865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E8L03_RS06880	COG3956	TIGRFAM MazG family protein
E8L03_RS06885	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E8L03_RS06890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E8L03_RS06895	COG0589	response to stress
E8L03_RS06910	COG1058	Belongs to the CinA family
E8L03_RS06910	COG1546	Belongs to the CinA family
E8L03_RS06935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E8L03_RS06940	COG1692	metallophosphoesterase
E8L03_RS06945	COG0303	'Molybdopterin
E8L03_RS06960	COG0784	Response regulator, receiver
E8L03_RS06960	COG2198	Histidine kinase
E8L03_RS06960	COG2205	protein histidine kinase activity
E8L03_RS06965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E8L03_RS06970	COG2205	protein histidine kinase activity
E8L03_RS06970	COG0784	Response regulator, receiver
E8L03_RS06970	COG2198	Histidine kinase
E8L03_RS06975	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E8L03_RS06980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E8L03_RS06990	COG1811	Na channel or pump
E8L03_RS07020	COG0251	oxidation-reduction process
E8L03_RS07025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E8L03_RS07040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E8L03_RS07040	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8L03_RS07045	COG0069	glutamate synthase activity
E8L03_RS07055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E8L03_RS07060	COG0174	glutamine synthetase
E8L03_RS07075	COG3302	dmso reductase anchor subunit
E8L03_RS07085	COG0243	molybdopterin cofactor binding
E8L03_RS07100	COG5002	protein histidine kinase activity
E8L03_RS07100	COG0784	Response regulator, receiver
E8L03_RS07100	COG2205	protein histidine kinase activity
E8L03_RS07110	COG0784	Response regulator, receiver
E8L03_RS07110	COG2198	Histidine kinase
E8L03_RS07110	COG2205	protein histidine kinase activity
E8L03_RS07115	COG3604	Transcriptional regulator
E8L03_RS07120	COG2084	Dehydrogenase
E8L03_RS07125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8L03_RS07150	COG2721	sulfolactate sulfo-lyase activity
E8L03_RS07155	COG2721	sulfolactate sulfo-lyase activity
E8L03_RS07165	COG2048	Heterodisulfide reductase, subunit B
E8L03_RS07170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E8L03_RS07220	COG0723	plastoquinol--plastocyanin reductase activity
E8L03_RS07225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E8L03_RS07240	COG3119	arylsulfatase activity
E8L03_RS07265	COG2207	Transcriptional regulator
E8L03_RS07280	COG0667	Aldo Keto reductase
E8L03_RS07285	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
E8L03_RS07290	COG1606	tRNA processing
E8L03_RS07295	COG1691	(AIR) carboxylase
E8L03_RS07300	COG1346	cytolysis
E8L03_RS07310	COG0583	DNA-binding transcription factor activity
E8L03_RS07325	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8L03_RS07330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8L03_RS07335	COG4565	transcriptional regulatory protein
E8L03_RS07340	COG3290	protein histidine kinase activity
E8L03_RS07350	COG0251	oxidation-reduction process
E8L03_RS07395	COG0191	fructose-bisphosphate aldolase activity
E8L03_RS07415	COG2721	sulfolactate sulfo-lyase activity
E8L03_RS07420	COG2721	sulfolactate sulfo-lyase activity
E8L03_RS07425	COG3875	lactate racemase activity
E8L03_RS07435	COG3604	Transcriptional regulator
E8L03_RS07440	COG0701	Predicted permease
E8L03_RS07460	COG0583	DNA-binding transcription factor activity
E8L03_RS07475	COG0589	response to stress
E8L03_RS07515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8L03_RS07520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8L03_RS07535	COG0277	FAD linked oxidase domain protein
E8L03_RS07540	COG0247	lactate metabolic process
E8L03_RS07550	COG0583	DNA-binding transcription factor activity
E8L03_RS07555	COG0281	malic enzyme
E8L03_RS07560	COG3875	lactate racemase activity
E8L03_RS07565	COG2801	Transposase and inactivated derivatives
E8L03_RS07570	COG1609	Transcriptional regulator
E8L03_RS07575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8L03_RS07580	COG0129	dihydroxy-acid dehydratase activity
E8L03_RS07605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E8L03_RS07610	COG1121	(ABC) transporter
E8L03_RS07620	COG0803	Belongs to the bacterial solute-binding protein 9 family
E8L03_RS07645	COG2217	Heavy metal translocating P-type atpase
E8L03_RS07660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E8L03_RS07670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8L03_RS07675	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8L03_RS07685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E8L03_RS07695	COG0706	membrane insertase activity
E8L03_RS07700	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E8L03_RS07705	COG0594	ribonuclease P activity
E8L03_RS07710	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E8L03_RS07740	COG0612	Peptidase, M16
E8L03_RS07750	COG0330	HflC and HflK could
E8L03_RS07765	COG4822	anaerobic cobalamin biosynthetic process
E8L03_RS07770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8L03_RS07775	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E8L03_RS07800	COG2264	protein methyltransferase activity
E8L03_RS07805	COG0033	Phosphoglucomutase
E8L03_RS07820	COG0720	synthase
E8L03_RS07825	COG2801	Transposase and inactivated derivatives
E8L03_RS07825	COG3415	Transposase
E8L03_RS07835	COG1490	D-aminoacyl-tRNA deacylase activity
E8L03_RS07845	COG2172	sigma factor antagonist activity
E8L03_RS07860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E8L03_RS07885	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E8L03_RS07900	COG0571	ribonuclease III activity
E8L03_RS07910	COG0857	belongs to the CobB CobQ family
E8L03_RS07925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E8L03_RS07940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E8L03_RS07945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E8L03_RS07955	COG0772	Belongs to the SEDS family
E8L03_RS07965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E8L03_RS07970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E8L03_RS07975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E8L03_RS07990	COG0275	rRNA processing
E8L03_RS08050	COG1280	lysine exporter protein (LysE YggA)
E8L03_RS08055	COG0243	molybdopterin cofactor binding
E8L03_RS08070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E8L03_RS08075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E8L03_RS08080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E8L03_RS08100	COG3290	protein histidine kinase activity
E8L03_RS08100	COG0840	transmembrane signaling receptor activity
E8L03_RS08105	COG4191	Histidine kinase
E8L03_RS08105	COG0745	RESPONSE REGULATOR receiver
E8L03_RS08105	COG2205	protein histidine kinase activity
E8L03_RS08180	COG2027	D-alanyl-D-alanine carboxypeptidase
E8L03_RS08200	COG3437	response regulator, receiver
E8L03_RS08200	COG2770	Histidine kinase
E8L03_RS08210	COG1959	2 iron, 2 sulfur cluster binding
E8L03_RS08220	COG2951	lytic endotransglycosylase activity
E8L03_RS08250	COG1192	Involved in chromosome partitioning
E8L03_RS08270	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E8L03_RS08275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E8L03_RS08280	COG5557	Pfam Polysulphide reductase, NrfD
E8L03_RS08285	COG0437	4 iron, 4 sulfur cluster binding
E8L03_RS08290	COG0243	molybdopterin cofactor binding
E8L03_RS08320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E8L03_RS08330	COG0330	HflC and HflK could
E8L03_RS08335	COG0330	HflC and HflK could
E8L03_RS08345	COG0436	Aminotransferase
E8L03_RS08350	COG2204	response regulator
E8L03_RS08355	COG1691	(AIR) carboxylase
E8L03_RS08405	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E8L03_RS08420	COG2755	lipolytic protein G-D-S-L family
E8L03_RS08425	COG2202	Pas domain
E8L03_RS08425	COG2205	protein histidine kinase activity
E8L03_RS08430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E8L03_RS08445	COG0521	Mo-molybdopterin cofactor biosynthetic process
E8L03_RS08450	COG3028	Belongs to the UPF0307 family
E8L03_RS08460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E8L03_RS08480	COG0840	transmembrane signaling receptor activity
E8L03_RS08495	COG0469	pyruvate kinase activity
E8L03_RS08535	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E8L03_RS08535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E8L03_RS08550	COG2208	phosphoserine phosphatase activity
E8L03_RS08550	COG2770	Histidine kinase
E8L03_RS08565	COG5002	protein histidine kinase activity
E8L03_RS08585	COG2210	Belongs to the sulfur carrier protein TusA family
E8L03_RS08595	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E8L03_RS08600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E8L03_RS08630	COG2205	protein histidine kinase activity
E8L03_RS08630	COG0784	Response regulator, receiver
E8L03_RS08635	COG3189	MarR family transcriptional regulator
E8L03_RS08640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E8L03_RS08660	COG3383	formate dehydrogenase (NAD+) activity
E8L03_RS08660	COG0243	molybdopterin cofactor binding
E8L03_RS08665	COG0437	4 iron, 4 sulfur cluster binding
E8L03_RS08680	COG1840	ABC-type Fe3 transport system, periplasmic component
E8L03_RS08685	COG1178	ABC-type Fe3 transport system permease component
E8L03_RS08690	COG3842	ATPase activity
E8L03_RS08775	COG2205	protein histidine kinase activity
E8L03_RS08775	COG0784	Response regulator, receiver
E8L03_RS08815	COG2201	protein-glutamate methylesterase activity
E8L03_RS08835	COG0745	RESPONSE REGULATOR receiver
E8L03_RS08840	COG2205	protein histidine kinase activity
E8L03_RS08855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E8L03_RS08865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E8L03_RS08880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E8L03_RS08885	COG0494	nUDIX hydrolase
E8L03_RS08920	COG1122	ATPase activity
E8L03_RS08965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E8L03_RS08970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E8L03_RS08980	COG0322	excinuclease ABC activity
E8L03_RS09005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E8L03_RS09025	COG0529	Catalyzes the synthesis of activated sulfate
E8L03_RS09030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E8L03_RS09035	COG1088	dTDP-glucose 4,6-dehydratase activity
E8L03_RS09050	COG1083	cytidylyl-transferase
E8L03_RS09070	COG0135	phosphoribosylanthranilate isomerase activity
E8L03_RS09075	COG1119	ATPase activity
E8L03_RS09095	COG0745	RESPONSE REGULATOR receiver
E8L03_RS09115	COG2770	Histidine kinase
E8L03_RS09115	COG2208	phosphoserine phosphatase activity
E8L03_RS09120	COG3457	Alanine racemase
E8L03_RS09130	COG0501	Belongs to the peptidase M48B family
E8L03_RS09135	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E8L03_RS09145	COG2198	Histidine kinase
E8L03_RS09145	COG0784	Response regulator, receiver
E8L03_RS09145	COG5002	protein histidine kinase activity
E8L03_RS09150	COG2201	protein-glutamate methylesterase activity
E8L03_RS09180	COG4175	Glycine betaine
E8L03_RS09180	COG3448	diguanylate cyclase activity
E8L03_RS09200	COG1234	tRNA 3'-trailer cleavage
E8L03_RS09210	COG0058	SHG alpha-glucan phosphorylase activity
E8L03_RS09215	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
E8L03_RS09235	COG4191	Histidine kinase
E8L03_RS09235	COG0784	Response regulator, receiver
E8L03_RS09245	COG0745	RESPONSE REGULATOR receiver
E8L03_RS09295	COG4968	Prepilin-type N-terminal cleavage methylation domain
E8L03_RS09310	COG1595	DNA-templated transcription, initiation
E8L03_RS09315	COG0577	efflux transmembrane transporter activity
E8L03_RS09315	COG1136	(ABC) transporter
E8L03_RS09335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E8L03_RS09365	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E8L03_RS09370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E8L03_RS09375	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E8L03_RS09380	COG0728	peptidoglycan biosynthetic process
E8L03_RS09385	COG0450	alkyl hydroperoxide reductase
E8L03_RS09400	COG0028	Belongs to the TPP enzyme family
E8L03_RS09410	COG0840	transmembrane signaling receptor activity
E8L03_RS09420	COG2205	protein histidine kinase activity
E8L03_RS09420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8L03_RS09425	COG0788	formyltetrahydrofolate deformylase activity
E8L03_RS09430	COG0668	transmembrane transport
E8L03_RS09440	COG2855	membrane
E8L03_RS09445	COG0583	DNA-binding transcription factor activity
E8L03_RS09455	COG0459	protein refolding
E8L03_RS09460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E8L03_RS09465	COG0436	Aminotransferase
E8L03_RS09475	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
E8L03_RS09480	COG0824	Thioesterase
E8L03_RS09490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E8L03_RS09535	COG1028	Short-chain dehydrogenase reductase Sdr
E8L03_RS09555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E8L03_RS09565	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E8L03_RS09570	COG0052	Belongs to the universal ribosomal protein uS2 family
E8L03_RS09580	COG0528	UMP kinase activity
E8L03_RS09600	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E8L03_RS09605	COG0750	zinc metalloprotease
E8L03_RS09610	COG1214	PFAM Peptidase M22, glycoprotease
E8L03_RS09625	COG1516	flagellar protein fliS
E8L03_RS09640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E8L03_RS09660	COG0535	radical SAM domain protein
E8L03_RS09665	COG0113	porphobilinogen synthase activity
E8L03_RS09685	COG2181	nitrate reductase activity
E8L03_RS09710	COG2046	Belongs to the sulfate adenylyltransferase family
E8L03_RS09725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E8L03_RS09730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E8L03_RS09750	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E8L03_RS09755	COG0653	protein targeting
E8L03_RS09765	COG0277	FAD linked oxidase domain protein
E8L03_RS09770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E8L03_RS09780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8L03_RS09790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E8L03_RS09795	COG0792	nuclease activity
E8L03_RS09800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E8L03_RS09805	COG0335	large ribosomal subunit rRNA binding
E8L03_RS09810	COG0336	Belongs to the RNA methyltransferase TrmD family
E8L03_RS09810	COG4752	Belongs to the RNA methyltransferase TrmD family
E8L03_RS09820	COG1837	Belongs to the UPF0109 family
E8L03_RS09825	COG0228	four-way junction DNA binding
E8L03_RS09830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E8L03_RS09840	COG1136	(ABC) transporter
E8L03_RS09840	COG0577	efflux transmembrane transporter activity
E8L03_RS09845	COG0577	efflux transmembrane transporter activity
E8L03_RS09845	COG1136	(ABC) transporter
E8L03_RS09855	COG0328	RNA-DNA hybrid ribonuclease activity
E8L03_RS09890	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E8L03_RS09910	COG0432	Pfam Uncharacterised protein family UPF0047
E8L03_RS09915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E8L03_RS09935	COG1394	ATPase activity, coupled to movement of substances
E8L03_RS09940	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E8L03_RS09945	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E8L03_RS09960	COG2205	protein histidine kinase activity
E8L03_RS09960	COG0784	Response regulator, receiver
E8L03_RS09960	COG5002	protein histidine kinase activity
E8L03_RS10000	COG0724	RNA recognition motif
E8L03_RS10005	COG0728	peptidoglycan biosynthetic process
E8L03_RS10010	COG0493	'glutamate synthase
E8L03_RS10065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E8L03_RS10070	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E8L03_RS10080	COG2205	protein histidine kinase activity
E8L03_RS10080	COG0784	Response regulator, receiver
E8L03_RS10080	COG2198	Histidine kinase
E8L03_RS10150	COG1396	sequence-specific DNA binding
E8L03_RS10170	COG0840	transmembrane signaling receptor activity
E8L03_RS10170	COG3290	protein histidine kinase activity
E8L03_RS10180	COG1744	ABC transporter substrate-binding protein PnrA-like
E8L03_RS10185	COG0076	glutamate decarboxylase activity
E8L03_RS10225	COG0538	isocitrate dehydrogenase activity
E8L03_RS10230	COG1218	3'(2'),5'-bisphosphate nucleotidase
E8L03_RS10255	COG1846	Transcriptional regulator
E8L03_RS10270	COG1132	(ABC) transporter
E8L03_RS10290	COG1294	oxidase, subunit
E8L03_RS10295	COG1271	oxidase subunit
E8L03_RS10300	COG0604	alcohol dehydrogenase
E8L03_RS10310	COG1773	rubredoxin
E8L03_RS10315	COG0840	transmembrane signaling receptor activity
E8L03_RS10320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E8L03_RS10325	COG0142	geranyltranstransferase activity
E8L03_RS10345	COG2226	methyltransferase
E8L03_RS10370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E8L03_RS10380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E8L03_RS10385	COG0432	Pfam Uncharacterised protein family UPF0047
E8L03_RS10400	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E8L03_RS10415	COG1797	cobyrinic acid a,c-diamide synthase activity
E8L03_RS10430	COG4399	Belongs to the UPF0754 family
E8L03_RS10465	COG2414	aldehyde ferredoxin oxidoreductase
E8L03_RS10470	COG1295	ribonuclease BN
E8L03_RS10475	COG1022	Amp-dependent synthetase and ligase
E8L03_RS10520	COG0835	chemotaxis
E8L03_RS10525	COG0840	transmembrane signaling receptor activity
E8L03_RS10560	COG0671	phosphoesterase, PA-phosphatase related
E8L03_RS10570	COG0366	Alpha amylase catalytic
E8L03_RS10580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E8L03_RS10590	COG2801	Transposase and inactivated derivatives
E8L03_RS10615	COG2205	protein histidine kinase activity
E8L03_RS10615	COG0784	Response regulator, receiver
E8L03_RS10625	COG0693	protein deglycase activity
E8L03_RS10630	COG0784	Response regulator, receiver
E8L03_RS10630	COG2205	protein histidine kinase activity
E8L03_RS10685	COG2827	Endonuclease containing a URI domain
E8L03_RS10705	COG1151	hydroxylamine reductase activity
E8L03_RS10710	COG0724	RNA recognition motif
E8L03_RS10715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E8L03_RS10730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E8L03_RS10740	COG3608	succinylglutamate desuccinylase aspartoacylase
E8L03_RS10740	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E8L03_RS10755	COG0784	Response regulator, receiver
E8L03_RS10755	COG2198	Histidine kinase
E8L03_RS10755	COG2205	protein histidine kinase activity
E8L03_RS10790	COG0501	Belongs to the peptidase M48B family
E8L03_RS10810	COG1566	PFAM secretion protein HlyD family protein
E8L03_RS10815	COG2814	Major facilitator Superfamily
E8L03_RS10825	COG2814	Major facilitator Superfamily
E8L03_RS10840	COG3290	protein histidine kinase activity
E8L03_RS10840	COG3829	transcription factor binding
E8L03_RS10850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E8L03_RS10855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E8L03_RS10860	COG1116	anion transmembrane transporter activity
E8L03_RS10900	COG1362	aminopeptidase activity
E8L03_RS10910	COG1921	L-seryl-tRNASec selenium transferase activity
E8L03_RS10915	COG0285	dihydrofolate synthase activity
E8L03_RS10925	COG0582	viral genome integration into host DNA
E8L03_RS10955	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E8L03_RS10975	COG1017	nitric oxide dioxygenase activity
E8L03_RS10975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E8L03_RS10980	COG0840	transmembrane signaling receptor activity
E8L03_RS11000	COG1304	FMN binding
E8L03_RS11010	COG2204	response regulator
E8L03_RS11015	COG1620	l-lactate permease
E8L03_RS11020	COG0277	FAD linked oxidase domain protein
E8L03_RS11025	COG0247	lactate metabolic process
E8L03_RS11030	COG0857	belongs to the CobB CobQ family
E8L03_RS11030	COG0280	phosphate acetyltransferase
E8L03_RS11035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E8L03_RS11055	COG0420	3'-5' exonuclease activity
E8L03_RS11070	COG1083	cytidylyl-transferase
E8L03_RS11125	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E8L03_RS11170	COG0784	Response regulator, receiver
E8L03_RS11170	COG2205	protein histidine kinase activity
E8L03_RS11175	COG2423	ornithine cyclodeaminase activity
E8L03_RS11190	COG2081	HI0933 family
E8L03_RS11210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E8L03_RS11215	COG0348	domain, Protein
E8L03_RS11235	COG0702	epimerase
E8L03_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
E8L03_RS11280	COG1028	Short-chain dehydrogenase reductase Sdr
E8L03_RS11325	COG1268	BioY protein
E8L03_RS11330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E8L03_RS11335	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E8L03_RS11345	COG0210	DNA helicase
E8L03_RS11365	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E8L03_RS11370	COG0315	cyclic pyranopterin monophosphate synthase activity
E8L03_RS11370	COG0746	molybdenum cofactor guanylyltransferase activity
E8L03_RS11375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E8L03_RS11405	COG0655	NAD(P)H dehydrogenase (quinone) activity
E8L03_RS11410	COG3706	GGDEF domain
E8L03_RS11430	COG2815	serine threonine protein kinase
E8L03_RS11430	COG0515	serine threonine protein kinase
E8L03_RS11460	COG2801	Transposase and inactivated derivatives
E8L03_RS11500	COG1414	Transcriptional regulator
E8L03_RS11515	COG1013	pyruvate-flavodoxin oxidoreductase activity
E8L03_RS11535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E8L03_RS11540	COG2076	Multidrug Resistance protein
E8L03_RS11545	COG0277	FAD linked oxidase domain protein
E8L03_RS11550	COG0247	lactate metabolic process
E8L03_RS11605	COG0643	Histidine kinase
E8L03_RS11605	COG2198	Histidine kinase
E8L03_RS11615	COG0835	chemotaxis
E8L03_RS11630	COG1162	GTPase activity
E8L03_RS11635	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E8L03_RS11640	COG1034	ATP synthesis coupled electron transport
E8L03_RS11655	COG0649	NAD binding
E8L03_RS11655	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8L03_RS11655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8L03_RS11660	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8L03_RS11665	COG1271	oxidase subunit
E8L03_RS11675	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8L03_RS11685	COG0713	ATP synthesis coupled electron transport
E8L03_RS11690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E8L03_RS11700	COG1007	ATP synthesis coupled electron transport
E8L03_RS11710	COG2182	Extracellular solute-binding protein
E8L03_RS11715	COG1175	transmembrane transport
E8L03_RS11740	COG1070	Carbohydrate kinase
E8L03_RS11755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8L03_RS11770	COG1122	ATPase activity
E8L03_RS11775	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E8L03_RS11835	COG4690	dipeptidase activity
E8L03_RS11840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E8L03_RS11850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E8L03_RS11855	COG4608	Belongs to the ABC transporter superfamily
E8L03_RS11860	COG0444	Belongs to the ABC transporter superfamily
E8L03_RS11875	COG0747	negative chemotaxis
E8L03_RS11890	COG3842	ATPase activity
E8L03_RS11895	COG0725	ABC transporter, periplasmic molybdate-binding protein
E8L03_RS11900	COG4149	molybdate abc transporter
E8L03_RS11955	COG2226	methyltransferase
E8L03_RS11975	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E8L03_RS11995	COG0543	2 iron, 2 sulfur cluster binding
E8L03_RS12005	COG2204	response regulator
E8L03_RS12015	COG1053	succinate dehydrogenase
E8L03_RS12020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E8L03_RS12035	COG0281	malic enzyme
E8L03_RS12035	COG0280	phosphate acetyltransferase
E8L03_RS12040	COG0471	metal ion transport
E8L03_RS12040	COG0490	domain, Protein
E8L03_RS12050	COG3852	Histidine kinase
E8L03_RS12055	COG2204	response regulator
E8L03_RS12060	COG1454	alcohol dehydrogenase
E8L03_RS12070	COG2048	Heterodisulfide reductase, subunit B
E8L03_RS12075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E8L03_RS12120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E8L03_RS12135	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E8L03_RS12145	COG4191	Histidine kinase
E8L03_RS12150	COG2204	response regulator
E8L03_RS12160	COG2204	response regulator
E8L03_RS12180	COG0574	Belongs to the PEP-utilizing enzyme family
E8L03_RS12180	COG3848	Pyruvate phosphate dikinase
E8L03_RS12185	COG5002	protein histidine kinase activity
E8L03_RS12195	COG0745	RESPONSE REGULATOR receiver
E8L03_RS12210	COG0668	transmembrane transport
E8L03_RS12215	COG0647	UMP catabolic process
E8L03_RS12220	COG0288	reversible hydration of carbon dioxide
E8L03_RS12225	COG2204	response regulator
E8L03_RS12260	COG1181	Belongs to the D-alanine--D-alanine ligase family
E8L03_RS12265	COG1509	lysine 2,3-aminomutase activity
E8L03_RS12275	COG2204	response regulator
E8L03_RS12280	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E8L03_RS12280	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E8L03_RS12310	COG0708	Exodeoxyribonuclease III
E8L03_RS12330	COG1053	succinate dehydrogenase
E8L03_RS12335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E8L03_RS12360	COG0835	chemotaxis
E8L03_RS12360	COG0784	Response regulator, receiver
E8L03_RS12365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E8L03_RS12370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E8L03_RS12375	COG4608	Belongs to the ABC transporter superfamily
E8L03_RS12380	COG0444	Belongs to the ABC transporter superfamily
E8L03_RS12385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E8L03_RS12395	COG0747	negative chemotaxis
E8L03_RS12410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E8L03_RS12415	COG2271	Major facilitator Superfamily
E8L03_RS12435	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8L03_RS12445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E8L03_RS12475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E8L03_RS12505	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E8L03_RS12505	COG1918	ferrous iron import across plasma membrane
E8L03_RS12515	COG1684	flagellar biosynthetic protein fliR
E8L03_RS12520	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E8L03_RS12525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E8L03_RS12530	COG1419	protein localization to endoplasmic reticulum
E8L03_RS12540	COG1191	sigma factor activity
E8L03_RS12565	COG2801	Transposase and inactivated derivatives
E8L03_RS12585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E8L03_RS12605	COG2204	response regulator
E8L03_RS12635	COG2204	response regulator
E8L03_RS12645	COG0643	Histidine kinase
E8L03_RS12645	COG2198	Histidine kinase
E8L03_RS12670	COG2204	response regulator
E8L03_RS12685	COG0693	protein deglycase activity
E8L03_RS12695	COG0641	radical SAM
E8L03_RS12700	COG3119	arylsulfatase activity
E8L03_RS12735	COG4302	ethanolamine ammonia-lyase activity
E8L03_RS12740	COG4303	Ethanolamine ammonia lyase large subunit
E8L03_RS12765	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E8L03_RS12800	COG1280	lysine exporter protein (LysE YggA)
E8L03_RS12805	COG5002	protein histidine kinase activity
E8L03_RS12815	COG4206	TonB-dependent receptor
E8L03_RS12830	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E8L03_RS12840	COG4662	Binding-protein-dependent transport system inner membrane component
E8L03_RS12850	COG0437	4 iron, 4 sulfur cluster binding
E8L03_RS12850	COG3064	Membrane
E8L03_RS12875	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
E8L03_RS12880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E8L03_RS12885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E8L03_RS12885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E8L03_RS12895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8L03_RS12910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E8L03_RS12920	COG1349	DNA-binding transcription factor activity
E8L03_RS12945	COG0481	GTPase activity
E8L03_RS12960	COG3279	Response regulator of the LytR AlgR family
E8L03_RS12965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E8L03_RS12980	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E8L03_RS12985	COG1640	4-alpha-glucanotransferase
E8L03_RS13000	COG0505	Belongs to the CarA family
E8L03_RS13010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E8L03_RS13035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E8L03_RS13040	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E8L03_RS13050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E8L03_RS13060	COG0406	alpha-ribazole phosphatase activity
E8L03_RS13105	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E8L03_RS13110	COG0438	transferase activity, transferring glycosyl groups
E8L03_RS13155	COG1216	Glycosyl transferase, family 2
E8L03_RS13155	COG0438	transferase activity, transferring glycosyl groups
E8L03_RS13165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E8L03_RS13175	COG2801	Transposase and inactivated derivatives
E8L03_RS13180	COG2801	Transposase and inactivated derivatives
E8L03_RS13195	COG0492	ferredoxin-NADP+ reductase activity
E8L03_RS13200	COG3118	belongs to the thioredoxin family
E8L03_RS13210	COG1028	Short-chain dehydrogenase reductase Sdr
E8L03_RS13215	COG0280	phosphate acetyltransferase
E8L03_RS13215	COG0281	malic enzyme
E8L03_RS13220	COG1250	3-hydroxyacyl-CoA dehydrogenase
E8L03_RS13225	COG0410	ABC transporter
E8L03_RS13250	COG1028	Short-chain dehydrogenase reductase Sdr
E8L03_RS13255	COG3875	lactate racemase activity
E8L03_RS13265	COG0126	phosphoglycerate kinase activity
E8L03_RS13275	COG1609	Transcriptional regulator
E8L03_RS13290	COG1012	belongs to the aldehyde dehydrogenase family
E8L03_RS13295	COG0045	succinate-CoA ligase (ADP-forming) activity
E8L03_RS13300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E8L03_RS13320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E8L03_RS13325	COG0543	2 iron, 2 sulfur cluster binding
E8L03_RS13340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E8L03_RS13345	COG3387	PFAM Glycoside hydrolase 15-related
E8L03_RS13355	COG0506	proline dehydrogenase activity
E8L03_RS13365	COG2267	carboxylic ester hydrolase activity
E8L03_RS13400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E8L03_RS13410	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E8L03_RS13420	COG0004	ammonium transporteR
E8L03_RS13425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E8L03_RS13440	COG0004	ammonium transporteR
E8L03_RS13445	COG1830	Aldolase
E8L03_RS13450	COG1830	Aldolase
E8L03_RS13455	COG1465	3-dehydroquinate synthase
E8L03_RS13460	COG1605	Chorismate mutase
E8L03_RS13460	COG0077	Prephenate dehydratase
E8L03_RS13465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E8L03_RS13475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E8L03_RS13480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E8L03_RS13480	COG0512	Glutamine amidotransferase of anthranilate synthase
E8L03_RS13485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E8L03_RS13490	COG0134	indole-3-glycerol-phosphate synthase activity
E8L03_RS13495	COG0135	phosphoribosylanthranilate isomerase activity
E8L03_RS13500	COG0133	tryptophan synthase activity
E8L03_RS13505	COG0159	tryptophan synthase activity
E8L03_RS13530	COG0409	Hydrogenase expression formation protein
E8L03_RS13545	COG0411	ABC transporter
E8L03_RS13595	COG1366	Belongs to the anti-sigma-factor antagonist family
E8L03_RS13605	COG4662	Binding-protein-dependent transport system inner membrane component
E8L03_RS13610	COG2998	abc-type tungstate transport system, permease component
E8L03_RS13620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E8L03_RS13625	COG2204	response regulator
E8L03_RS13650	COG1686	Belongs to the peptidase S11 family
E8L03_RS13660	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E8L03_RS13670	COG0138	bifunctional purine biosynthesis protein purh
E8L03_RS13680	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E8L03_RS13690	COG0470	DNA polymerase III
E8L03_RS13695	COG0745	RESPONSE REGULATOR receiver
E8L03_RS13705	COG0251	oxidation-reduction process
E8L03_RS13715	COG0492	ferredoxin-NADP+ reductase activity
E8L03_RS13720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E8L03_RS13725	COG2198	Histidine kinase
E8L03_RS13725	COG2205	protein histidine kinase activity
E8L03_RS13725	COG0784	Response regulator, receiver
E8L03_RS13730	COG3304	Inner membrane component domain
E8L03_RS13735	COG0126	phosphoglycerate kinase activity
E8L03_RS13740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E8L03_RS13745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E8L03_RS13755	COG0072	phenylalanine-tRNA ligase activity
E8L03_RS13755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8L03_RS13760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E8L03_RS13770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E8L03_RS13780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E8L03_RS13815	COG1418	mRNA catabolic process
E8L03_RS13835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E8L03_RS13840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E8L03_RS13850	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E8L03_RS13855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E8L03_RS13860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E8L03_RS13880	COG0772	Belongs to the SEDS family
E8L03_RS13885	COG0768	penicillin binding
E8L03_RS13900	COG1077	Cell shape determining protein MreB Mrl
E8L03_RS13905	COG1242	4 iron, 4 sulfur cluster binding
E8L03_RS13920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E8L03_RS13930	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E8L03_RS13935	COG0148	phosphopyruvate hydratase activity
E8L03_RS13955	COG0564	pseudouridine synthase activity
E8L03_RS13960	COG0280	phosphate acetyltransferase
E8L03_RS13960	COG0281	malic enzyme
E8L03_RS13990	COG2095	MarC family integral membrane protein
E8L03_RS14015	COG2193	ferroxidase activity
E8L03_RS14020	COG1473	amidohydrolase
E8L03_RS14025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8L03_RS14030	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8L03_RS14035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8L03_RS14040	COG0589	response to stress
E8L03_RS14045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8L03_RS14055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E8L03_RS14060	COG2423	ornithine cyclodeaminase activity
E8L03_RS14065	COG0006	proline dipeptidase activity
E8L03_RS14070	COG1522	sequence-specific DNA binding
E8L03_RS14075	COG0686	Belongs to the AlaDH PNT family
E8L03_RS14085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E8L03_RS14100	COG0840	transmembrane signaling receptor activity
E8L03_RS14135	COG0640	Transcriptional regulator
E8L03_RS14155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E8L03_RS14165	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E8L03_RS14170	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E8L03_RS14175	COG1309	transcriptional regulator
E8L03_RS14180	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
E8L03_RS14185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E8L03_RS14210	COG0101	tRNA pseudouridine synthase activity
E8L03_RS14215	COG1111	helicase
E8L03_RS14215	COG1205	dead DEAH box helicase
E8L03_RS14220	COG2204	response regulator
E8L03_RS14225	COG4191	Histidine kinase
E8L03_RS14235	COG1489	DNA binding
E8L03_RS14250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E8L03_RS14260	COG1360	Flagellar Motor Protein
E8L03_RS14285	COG1338	Plays a role in the flagellum-specific transport system
E8L03_RS14290	COG1987	bacterial-type flagellum assembly
E8L03_RS14305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E8L03_RS14310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E8L03_RS14320	COG0674	pyruvate-flavodoxin oxidoreductase activity
E8L03_RS14330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E8L03_RS14340	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E8L03_RS14355	COG0330	HflC and HflK could
E8L03_RS14370	COG1192	Involved in chromosome partitioning
E8L03_RS14380	COG1475	DNA binding
E8L03_RS14385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E8L03_RS14385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E8L03_RS14390	COG2208	phosphoserine phosphatase activity
E8L03_RS14400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E8L03_RS14440	COG0242	peptide deformylase activity
E8L03_RS14445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E8L03_RS14450	COG0124	histidyl-tRNA synthetase
E8L03_RS14455	COG2226	methyltransferase
E8L03_RS14460	COG0129	dihydroxy-acid dehydratase activity
E8L03_RS14465	COG2177	Part of the ABC transporter FtsEX involved in
E8L03_RS14470	COG2884	Cell division ATP-binding protein ftsE
E8L03_RS14480	COG2814	Major facilitator Superfamily
E8L03_RS14485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E8L03_RS14490	COG1842	Phage shock protein A
E8L03_RS14520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E8L03_RS14530	COG0187	DNA topoisomerase II activity
E8L03_RS14535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E8L03_RS14545	COG5002	protein histidine kinase activity
E8L03_RS14545	COG2198	Histidine kinase
E8L03_RS14545	COG0784	Response regulator, receiver
E8L03_RS14565	COG1194	a g-specific adenine glycosylase
E8L03_RS14570	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
E8L03_RS14575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E8L03_RS14595	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E8L03_RS14630	COG2208	phosphoserine phosphatase activity
E8L03_RS14665	COG0835	chemotaxis
E8L03_RS14670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E8L03_RS14675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E8L03_RS14680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E8L03_RS14685	COG0617	tRNA 3'-terminal CCA addition
E8L03_RS14690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E8L03_RS14695	COG0540	Belongs to the ATCase OTCase family
E8L03_RS14700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E8L03_RS14715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E8L03_RS14720	COG0537	adenosine 5'-monophosphoramidase activity
E8L03_RS14730	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E8L03_RS14735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E8L03_RS14745	COG1067	ATP-dependent peptidase activity
E8L03_RS14770	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E8L03_RS14790	COG3706	GGDEF domain
E8L03_RS14795	COG0589	response to stress
E8L03_RS14815	COG0598	Magnesium transport protein CorA
E8L03_RS14820	COG2204	response regulator
E8L03_RS14825	COG4191	Histidine kinase
E8L03_RS14830	COG3678	ATP-independent chaperone mediated protein folding
E8L03_RS14840	COG0501	Belongs to the peptidase M48B family
E8L03_RS14855	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
E8L03_RS14860	COG0347	Belongs to the P(II) protein family
E8L03_RS14865	COG0347	Belongs to the P(II) protein family
E8L03_RS14900	COG1433	Dinitrogenase iron-molybdenum cofactor
E8L03_RS14900	COG0535	radical SAM domain protein
E8L03_RS14920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E8L03_RS14930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E8L03_RS14940	COG0463	Glycosyl transferase, family 2
E8L03_RS14965	COG1690	Belongs to the RtcB family
E8L03_RS14980	COG2911	Protein conserved in bacteria
E8L03_RS14990	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E8L03_RS15005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8L03_RS15010	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8L03_RS15015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8L03_RS15020	COG0649	NAD binding
E8L03_RS15025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E8L03_RS15040	COG0713	ATP synthesis coupled electron transport
E8L03_RS15045	COG0651	ATP synthesis coupled electron transport
E8L03_RS15065	COG1007	ATP synthesis coupled electron transport
E8L03_RS15080	COG2221	Nitrite and sulphite reductase 4Fe-4S
E8L03_RS15085	COG2221	Nitrite and sulphite reductase 4Fe-4S
E8L03_RS15095	COG1797	cobyrinic acid a,c-diamide synthase activity
E8L03_RS15105	COG0515	serine threonine protein kinase
E8L03_RS15120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E8L03_RS15125	COG4619	ABC transporter
E8L03_RS15135	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E8L03_RS15145	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E8L03_RS15150	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E8L03_RS15155	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E8L03_RS15170	COG0860	N-Acetylmuramoyl-L-alanine amidase
E8L03_RS15170	COG2247	cell wall binding repeat
E8L03_RS15175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E8L03_RS15180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E8L03_RS15190	COG3852	Histidine kinase
E8L03_RS15195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E8L03_RS15205	COG0616	signal peptide processing
E8L03_RS15220	COG1773	rubredoxin
E8L03_RS15230	COG0037	tRNA processing
E8L03_RS15240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E8L03_RS15245	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E8L03_RS15265	COG0564	pseudouridine synthase activity
E8L03_RS15290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E8L03_RS15290	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E8L03_RS15295	COG1830	Aldolase
E8L03_RS15310	COG0196	riboflavin kinase activity
E8L03_RS15330	COG1607	acyl-coa hydrolase
E8L03_RS15335	COG0730	response to heat
E8L03_RS15345	COG5002	protein histidine kinase activity
E8L03_RS15400	COG0590	tRNA wobble adenosine to inosine editing
E8L03_RS15550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E8L03_RS15615	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E8L03_RS15620	COG2204	response regulator
E8L03_RS15625	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E8L03_RS15655	COG0745	RESPONSE REGULATOR receiver
E8L03_RS15660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E8L03_RS15660	COG0045	succinate-CoA ligase (ADP-forming) activity
E8L03_RS15660	COG1042	CoA-binding domain protein
E8L03_RS15665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E8L03_RS15690	COG1659	Linocin_M18 bacteriocin protein
E8L03_RS15700	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E8L03_RS15705	COG1518	maintenance of DNA repeat elements
E8L03_RS15735	COG2801	Transposase and inactivated derivatives
E8L03_RS15740	COG0572	uridine kinase
E8L03_RS15765	COG1215	transferase activity, transferring glycosyl groups
E8L03_RS15805	COG3158	transport of potassium into the cell
E8L03_RS15815	COG1414	Transcriptional regulator
E8L03_RS15820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8L03_RS15825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8L03_RS15830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8L03_RS15840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E8L03_RS15850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E8L03_RS15855	COG0840	transmembrane signaling receptor activity
E8L03_RS15875	COG0437	4 iron, 4 sulfur cluster binding
E8L03_RS15895	COG2205	protein histidine kinase activity
E8L03_RS15895	COG0784	Response regulator, receiver
E8L03_RS15930	COG2204	response regulator
E8L03_RS15935	COG2204	response regulator
E8L03_RS15940	COG5002	protein histidine kinase activity
E8L03_RS15950	COG0589	response to stress
E8L03_RS15970	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E8L03_RS15975	COG2204	response regulator
E8L03_RS15985	COG4778	phosphonate C-P lyase system protein PhnL
E8L03_RS15990	COG4107	phosphonate C-P lyase system protein PhnK
E8L03_RS15995	COG3627	carbon phosphorus lyase activity
E8L03_RS16000	COG3626	phosphonate metabolism
E8L03_RS16010	COG3624	Phosphonate C-P lyase system protein PhnG
E8L03_RS16015	COG2188	Transcriptional regulator
E8L03_RS16020	COG3639	organic phosphonate transmembrane transporter activity
E8L03_RS16025	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E8L03_RS16040	COG3177	Filamentation induced by cAMP protein fic
E8L03_RS16050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E8L03_RS16055	COG1846	Transcriptional regulator
E8L03_RS16090	COG1328	CTP reductase activity
E8L03_RS16090	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E8L03_RS16120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E8L03_RS16125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E8L03_RS16130	COG2391	methyltransferase activity
E8L03_RS16145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E8L03_RS16145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E8L03_RS16170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E8L03_RS16180	COG2885	chlorophyll binding
E8L03_RS16185	COG0596	Alpha beta hydrolase
E8L03_RS16190	COG0668	transmembrane transport
E8L03_RS16200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8L03_RS16205	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E8L03_RS16210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E8L03_RS16240	COG0840	transmembrane signaling receptor activity
E8L03_RS16245	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
E8L03_RS16255	COG0071	Belongs to the small heat shock protein (HSP20) family
E8L03_RS16260	COG0840	transmembrane signaling receptor activity
E8L03_RS16265	COG1012	belongs to the aldehyde dehydrogenase family
E8L03_RS16270	COG1522	sequence-specific DNA binding
E8L03_RS16275	COG2200	EAL domain
E8L03_RS16280	COG0284	orotidine-5'-phosphate decarboxylase activity
E8L03_RS16285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E8L03_RS16290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E8L03_RS16300	COG0438	transferase activity, transferring glycosyl groups
E8L03_RS16310	COG0739	heme binding
E8L03_RS16315	COG0037	tRNA processing
E8L03_RS16350	COG0315	cyclic pyranopterin monophosphate synthase activity
E8L03_RS16370	COG2801	Transposase and inactivated derivatives
E8L03_RS16395	COG2801	Transposase and inactivated derivatives
E8L03_RS16400	COG0107	imidazoleglycerol-phosphate synthase activity
E8L03_RS16405	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E8L03_RS16410	COG0668	transmembrane transport
E8L03_RS16420	COG2801	Transposase and inactivated derivatives
E8L03_RS16435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E8L03_RS16440	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E8L03_RS16445	COG5002	protein histidine kinase activity
E8L03_RS16460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E8L03_RS16485	COG0640	Transcriptional regulator
E8L03_RS16505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E8L03_RS16525	COG1924	4 iron, 4 sulfur cluster binding
E8L03_RS16535	COG0728	peptidoglycan biosynthetic process
E8L03_RS16545	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E8L03_RS16555	COG0180	Tryptophanyl-tRNA synthetase
E8L03_RS16560	COG1994	Peptidase M50
E8L03_RS16580	COG0037	tRNA processing
E8L03_RS16595	COG2135	peptidase activity
E8L03_RS16600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E8L03_RS16610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E8L03_RS16635	COG2204	response regulator
E8L03_RS16640	COG4191	Histidine kinase
E8L03_RS16645	COG2205	protein histidine kinase activity
E8L03_RS16645	COG2198	Histidine kinase
E8L03_RS16645	COG0784	Response regulator, receiver
E8L03_RS16660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E8L03_RS16670	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E8L03_RS16675	COG1136	(ABC) transporter
E8L03_RS16685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E8L03_RS16695	COG2226	methyltransferase
E8L03_RS16705	COG0840	transmembrane signaling receptor activity
E8L03_RS16710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E8L03_RS16715	COG2801	Transposase and inactivated derivatives
E8L03_RS16720	COG1881	PFAM PEBP family protein
E8L03_RS16725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E8L03_RS16740	COG0318	PFAM AMP-dependent synthetase and ligase
E8L03_RS16745	COG0175	sulfate reduction
E8L03_RS16870	COG1335	isochorismatase
E8L03_RS16875	COG0017	Asparaginyl-tRNA synthetase
E8L03_RS16885	COG0667	Aldo Keto reductase
E8L03_RS16895	COG2801	Transposase and inactivated derivatives
E8L03_RS16905	COG0138	bifunctional purine biosynthesis protein purh
E8L03_RS16925	COG1677	Flagellar hook-basal body complex protein FliE
E8L03_RS16930	COG1766	The M ring may be actively involved in energy transduction
E8L03_RS16935	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E8L03_RS16945	COG1157	protein secretion by the type III secretion system
E8L03_RS16965	COG0433	COG0433 Predicted ATPase
E8L03_RS16980	COG0588	phosphoglycerate mutase activity
E8L03_RS16985	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E8L03_RS16995	COG3872	metal-dependent enzyme
E8L03_RS17000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E8L03_RS17005	COG2890	protein-(glutamine-N5) methyltransferase activity
E8L03_RS17030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E8L03_RS17045	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E8L03_RS17050	COG0250	Participates in transcription elongation, termination and antitermination
E8L03_RS17055	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E8L03_RS17060	COG0081	regulation of translation
E8L03_RS17065	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E8L03_RS17070	COG0222	ribosome binding
E8L03_RS17075	COG0085	RNA polymerase activity
E8L03_RS17080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E8L03_RS17085	COG1090	epimerase
E8L03_RS17090	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E8L03_RS17095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E8L03_RS17105	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E8L03_RS17120	COG2192	nodulation
E8L03_RS17125	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E8L03_RS17140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E8L03_RS17145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E8L03_RS17150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E8L03_RS17160	COG0084	hydrolase, TatD family'
E8L03_RS17165	COG0552	protein localization to endoplasmic reticulum
E8L03_RS17175	COG2801	Transposase and inactivated derivatives
E8L03_RS17180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E8L03_RS17185	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E8L03_RS17190	COG1530	ribonuclease E activity
E8L03_RS17205	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E8L03_RS17215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E8L03_RS17220	COG2309	aminopeptidase activity
E8L03_RS17230	COG1360	Flagellar Motor Protein
E8L03_RS17235	COG1234	tRNA 3'-trailer cleavage
E8L03_RS17245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8L03_RS17255	COG2205	protein histidine kinase activity
E8L03_RS17255	COG0784	Response regulator, receiver
E8L03_RS17270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E8L03_RS17280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E8L03_RS17285	COG0359	binds to the 23S rRNA
E8L03_RS17290	COG0305	Participates in initiation and elongation during chromosome replication
E8L03_RS17295	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E8L03_RS17310	COG0517	IMP dehydrogenase activity
E8L03_RS17320	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
E8L03_RS17335	COG2835	tetraacyldisaccharide 4'-kinase activity
E8L03_RS17340	COG1331	Highly conserved protein containing a thioredoxin domain
E8L03_RS17345	COG0343	queuine tRNA-ribosyltransferase activity
E8L03_RS17360	COG0525	valine-tRNA ligase activity
E8L03_RS17365	COG1587	Uroporphyrinogen-III synthase
E8L03_RS17365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E8L03_RS17370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E8L03_RS17375	COG2078	PFAM AMMECR1 domain protein
E8L03_RS17390	COG2204	response regulator
E8L03_RS17390	COG2204	response regulator
E8L03_RS17405	COG0437	4 iron, 4 sulfur cluster binding
E8L03_RS17415	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E8L03_RS17420	COG0784	Response regulator, receiver
E8L03_RS17420	COG0835	chemotaxis
E8L03_RS17425	COG0776	regulation of translation
E8L03_RS17440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E8L03_RS17445	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E8L03_RS17460	COG0473	3-isopropylmalate dehydrogenase activity
E8L03_RS17485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E8L03_RS17500	COG1749	Flagellar hook protein flgE
E8L03_RS17505	COG2204	response regulator
E8L03_RS17515	COG1355	regulation of microtubule-based process
E8L03_RS17520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E8L03_RS17530	COG0181	hydroxymethylbilane synthase activity
E8L03_RS17550	COG0574	Belongs to the PEP-utilizing enzyme family
E8L03_RS17550	COG3848	Pyruvate phosphate dikinase
E8L03_RS17565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E8L03_RS17570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E8L03_RS17575	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E8L03_RS17580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E8L03_RS17590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E8L03_RS17590	COG3266	domain, Protein
E8L03_RS17600	COG0195	Participates in both transcription termination and antitermination
E8L03_RS17615	COG4786	Flagellar basal body rod
E8L03_RS17630	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E8L03_RS17635	COG1706	bacterial-type flagellum-dependent cell motility
E8L03_RS17640	COG0739	heme binding
E8L03_RS17650	COG1256	bacterial-type flagellum assembly
E8L03_RS17650	COG4786	Flagellar basal body rod
E8L03_RS17660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E8L03_RS17685	COG0424	maF-like protein
E8L03_RS17710	COG2226	methyltransferase
E8L03_RS17735	COG1309	transcriptional regulator
E8L03_RS17750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E8L03_RS17755	COG0789	Transcriptional regulator
E8L03_RS17780	COG2205	protein histidine kinase activity
E8L03_RS17780	COG0784	Response regulator, receiver
E8L03_RS17790	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E8L03_RS17815	COG0741	lytic transglycosylase activity
E8L03_RS17835	COG0631	protein serine/threonine phosphatase activity
E8L03_RS17840	COG0631	protein serine/threonine phosphatase activity
E8L03_RS17845	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E8L03_RS17850	COG0519	Catalyzes the synthesis of GMP from XMP
E8L03_RS17855	COG2885	chlorophyll binding
E8L03_RS17860	COG0823	Involved in the tonB-independent uptake of proteins
E8L03_RS17875	COG0811	peptide transport
E8L03_RS17880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E8L03_RS17895	COG5002	protein histidine kinase activity
E8L03_RS17920	COG0529	Catalyzes the synthesis of activated sulfate
E8L03_RS17930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E8L03_RS17935	COG1324	tolerance protein
E8L03_RS17940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E8L03_RS17975	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E8L03_RS17980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E8L03_RS17985	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E8L03_RS17990	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E8L03_RS18000	COG0351	phosphomethylpyrimidine kinase
E8L03_RS18000	COG0352	thiamine-phosphate diphosphorylase activity
E8L03_RS18030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E8L03_RS18055	COG1305	Transglutaminase-like
E8L03_RS18065	COG0714	Associated with various cellular activities
E8L03_RS18085	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E8L03_RS18085	COG0644	oxidoreductase
E8L03_RS18090	COG2205	protein histidine kinase activity
E8L03_RS18090	COG0784	Response regulator, receiver
E8L03_RS18105	COG0367	asparagine synthase
E8L03_RS18120	COG1192	Involved in chromosome partitioning
E8L03_RS18130	COG2203	Gaf domain
E8L03_RS18130	COG2200	EAL domain
E8L03_RS18130	COG2199	diguanylate cyclase activity
E8L03_RS18140	COG0745	RESPONSE REGULATOR receiver
E8L03_RS18150	COG1749	Flagellar hook protein flgE
E8L03_RS18165	COG1129	ABC transporter
E8L03_RS18200	COG2119	membrane
E8L03_RS18225	COG0837	glucose binding
E8L03_RS18230	COG0363	glucosamine-6-phosphate deaminase activity
E8L03_RS18235	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E8L03_RS18240	COG0784	Response regulator, receiver
E8L03_RS18240	COG2198	Histidine kinase
E8L03_RS18240	COG2205	protein histidine kinase activity
E8L03_RS18245	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E8L03_RS18260	COG2181	nitrate reductase activity
E8L03_RS18265	COG0247	lactate metabolic process
E8L03_RS18275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E8L03_RS18280	COG1830	Aldolase
E8L03_RS18290	COG1944	ATP diphosphatase activity
E8L03_RS18300	COG4181	ATPase activity
E8L03_RS18345	COG0006	proline dipeptidase activity
E8L03_RS18380	COG0438	transferase activity, transferring glycosyl groups
E8L03_RS18390	COG0602	queuosine metabolic process
E8L03_RS18395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E8L03_RS18405	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E8L03_RS18430	COG0745	RESPONSE REGULATOR receiver
E8L03_RS18450	COG2205	protein histidine kinase activity
E8L03_RS18450	COG0784	Response regulator, receiver
E8L03_RS18465	COG2205	protein histidine kinase activity
E8L03_RS18465	COG0784	Response regulator, receiver
E8L03_RS18480	COG0574	Belongs to the PEP-utilizing enzyme family
E8L03_RS18480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E8L03_RS18485	COG0039	L-malate dehydrogenase activity
E8L03_RS18495	COG3285	dna ligase
E8L03_RS18495	COG1793	dna ligase
E8L03_RS18510	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E8L03_RS18520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E8L03_RS18550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E8L03_RS18575	COG1615	UPF0182 protein
E8L03_RS18590	COG1846	Transcriptional regulator
E8L03_RS18595	COG0697	spore germination
E8L03_RS18600	COG2207	Transcriptional regulator
E8L03_RS18610	COG2205	protein histidine kinase activity
E8L03_RS18610	COG0784	Response regulator, receiver
E8L03_RS18615	COG0735	belongs to the Fur family
E8L03_RS18625	COG1773	rubredoxin
E8L03_RS18640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8L03_RS18645	COG0735	belongs to the Fur family
E8L03_RS18650	COG2193	ferroxidase activity
E8L03_RS18655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E8L03_RS18655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E8L03_RS18675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8L03_RS18690	COG0840	transmembrane signaling receptor activity
E8L03_RS18700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E8L03_RS18720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E8L03_RS18725	COG2186	Transcriptional regulator
E8L03_RS18730	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E8L03_RS18735	COG1012	belongs to the aldehyde dehydrogenase family
E8L03_RS18760	COG1136	(ABC) transporter
E8L03_RS18765	COG4591	ABC-type transport system involved in lipoprotein release permease component
E8L03_RS18785	COG0840	transmembrane signaling receptor activity
E8L03_RS18810	COG0395	ABC-type sugar transport system, permease component
E8L03_RS18820	COG3842	ATPase activity
E8L03_RS18825	COG3842	ATPase activity
E8L03_RS18830	COG1349	DNA-binding transcription factor activity
E8L03_RS18835	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E8L03_RS18855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E8L03_RS18860	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E8L03_RS18870	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E8L03_RS18875	COG0022	dehydrogenase e1 component
E8L03_RS18880	COG2205	protein histidine kinase activity
E8L03_RS18885	COG0745	RESPONSE REGULATOR receiver
E8L03_RS18910	COG4786	Flagellar basal body rod
E8L03_RS18910	COG1256	bacterial-type flagellum assembly
E8L03_RS18920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E8L03_RS18930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8L03_RS18935	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8L03_RS18940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8L03_RS18945	COG4251	negative regulation of phosphorylation
E8L03_RS18960	COG0697	spore germination
E8L03_RS18970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E8L03_RS18975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E8L03_RS18980	COG1027	Aspartate ammonia-lyase
E8L03_RS19005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E8L03_RS19005	COG4624	Iron only hydrogenase large subunit, C-terminal domain
E8L03_RS19015	COG0747	negative chemotaxis
E8L03_RS19020	COG0601	transmembrane transport
E8L03_RS19025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E8L03_RS19035	COG1124	(ABC) transporter
E8L03_RS19050	COG0326	Molecular chaperone. Has ATPase activity
E8L03_RS19095	COG4120	Belongs to the binding-protein-dependent transport system permease family
E8L03_RS19100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E8L03_RS19100	COG1116	anion transmembrane transporter activity
E8L03_RS19120	COG0321	lipoyl(octanoyl) transferase activity
E8L03_RS19125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E8L03_RS19130	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E8L03_RS19130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E8L03_RS19145	COG0194	GDP metabolic process
E8L03_RS19150	COG2052	Domain of unknown function (DUF370)
E8L03_RS19160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E8L03_RS19165	COG0482	sulfurtransferase activity
E8L03_RS19170	COG0154	amidase activity
E8L03_RS19175	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E8L03_RS19185	COG0443	Heat shock 70 kDa protein
E8L03_RS19190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E8L03_RS19195	COG1420	regulation of RNA biosynthetic process
E8L03_RS19205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E8L03_RS19225	COG1492	cobalamin metabolic process
E8L03_RS19260	COG2801	Transposase and inactivated derivatives
E8L03_RS19315	COG0390	transport system, permease component
E8L03_RS19325	COG5002	protein histidine kinase activity
E8L03_RS19325	COG0784	Response regulator, receiver
E8L03_RS19325	COG2198	Histidine kinase
E8L03_RS19330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E8L03_RS19350	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E8L03_RS19355	COG0277	FAD linked oxidase domain protein
E8L03_RS19365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E8L03_RS19370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E8L03_RS19380	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E8L03_RS19390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E8L03_RS19420	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E8L03_RS19425	COG0668	transmembrane transport
E8L03_RS19430	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E8L03_RS19430	COG0493	'glutamate synthase
E8L03_RS19435	COG0543	2 iron, 2 sulfur cluster binding
E8L03_RS19445	COG0191	fructose-bisphosphate aldolase activity
E8L03_RS19470	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E8L03_RS19475	COG0301	tRNA thio-modification
E8L03_RS19515	COG0167	dihydroorotate dehydrogenase activity
E8L03_RS19520	COG0543	2 iron, 2 sulfur cluster binding
E8L03_RS19540	COG0163	prenyltransferase activity
E8L03_RS19545	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E8L03_RS19575	COG1116	anion transmembrane transporter activity
E8L03_RS19595	COG4771	TonB-dependent receptor
E8L03_RS19605	COG4608	Belongs to the ABC transporter superfamily
E8L03_RS19610	COG0444	Belongs to the ABC transporter superfamily
E8L03_RS19615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E8L03_RS19620	COG0601	transmembrane transport
E8L03_RS19625	COG0747	negative chemotaxis
E8L03_RS19655	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E8L03_RS19655	COG1918	ferrous iron import across plasma membrane
E8L03_RS19680	COG0745	RESPONSE REGULATOR receiver
E8L03_RS19685	COG2198	Histidine kinase
E8L03_RS19685	COG0784	Response regulator, receiver
E8L03_RS19685	COG2205	protein histidine kinase activity
E8L03_RS19695	COG0519	Catalyzes the synthesis of GMP from XMP
E8L03_RS19730	COG2113	Glycine betaine
E8L03_RS19735	COG4176	ABC-type proline glycine betaine transport system permease component
E8L03_RS19740	COG4175	Glycine betaine
E8L03_RS19745	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E8L03_RS19750	COG3005	denitrification pathway
E8L03_RS19775	COG0842	Transport permease protein
E8L03_RS19780	COG0842	Transport permease protein
E8L03_RS19785	COG1131	(ABC) transporter
E8L03_RS19795	COG1309	transcriptional regulator
E8L03_RS19810	COG1592	Rubrerythrin
E8L03_RS19820	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E8L03_RS19845	COG4191	Histidine kinase
E8L03_RS19850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E8L03_RS19855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8L03_RS19875	COG0840	transmembrane signaling receptor activity
E8L03_RS19885	COG2205	protein histidine kinase activity
E8L03_RS19890	COG1032	radical SAM domain protein
E8L03_RS19895	COG2249	NAD(P)H dehydrogenase (quinone) activity
E8L03_RS19900	COG1278	Cold shock
E8L03_RS19905	COG1047	Peptidyl-prolyl cis-trans
E8L03_RS19945	COG2198	Histidine kinase
E8L03_RS19945	COG5002	protein histidine kinase activity
E8L03_RS19945	COG0784	Response regulator, receiver
E8L03_RS19975	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E8L03_RS19985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E8L03_RS20010	COG1666	GTP binding
E8L03_RS20020	COG1704	LemA family
E8L03_RS20030	COG1704	LemA family
E8L03_RS20045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E8L03_RS20055	COG1472	Belongs to the glycosyl hydrolase 3 family
E8L03_RS20070	COG1366	Belongs to the anti-sigma-factor antagonist family
E8L03_RS20075	COG4591	ABC-type transport system involved in lipoprotein release permease component
E8L03_RS20085	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E8L03_RS20120	COG2205	protein histidine kinase activity
E8L03_RS20120	COG2198	Histidine kinase
E8L03_RS20120	COG0784	Response regulator, receiver
E8L03_RS20140	COG1846	Transcriptional regulator
E8L03_RS20155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E8L03_RS20155	COG3153	acetyltransferase
E8L03_RS20160	COG0583	DNA-binding transcription factor activity
E8L03_RS20190	COG0765	amino acid transport
E8L03_RS20205	COG0765	amino acid transport
E8L03_RS20210	COG2988	succinylglutamate desuccinylase activity
E8L03_RS20240	COG2198	Histidine kinase
E8L03_RS20240	COG2205	protein histidine kinase activity
E8L03_RS20240	COG0784	Response regulator, receiver
E8L03_RS20245	COG2204	response regulator
E8L03_RS20280	COG4464	protein tyrosine phosphatase activity
E8L03_RS20310	COG0297	glycogen (starch) synthase activity
E8L03_RS20315	COG0438	transferase activity, transferring glycosyl groups
E8L03_RS20320	COG2770	Histidine kinase
E8L03_RS20320	COG3437	response regulator, receiver
E8L03_RS20325	COG2885	chlorophyll binding
E8L03_RS20325	COG3047	cAMP biosynthetic process
E8L03_RS20345	COG2089	acid synthase
E8L03_RS20350	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E8L03_RS20355	COG1122	ATPase activity
E8L03_RS20365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E8L03_RS20370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E8L03_RS20380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E8L03_RS20385	COG1121	(ABC) transporter
E8L03_RS20405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E8L03_RS20410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E8L03_RS20415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8L03_RS20425	COG2205	protein histidine kinase activity
E8L03_RS20425	COG0784	Response regulator, receiver
E8L03_RS20440	COG0166	Belongs to the GPI family
E8L03_RS20445	COG1247	-acetyltransferase
E8L03_RS20460	COG1686	Belongs to the peptidase S11 family
E8L03_RS20465	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E8L03_RS20475	COG3639	organic phosphonate transmembrane transporter activity
E8L03_RS20490	COG0437	4 iron, 4 sulfur cluster binding
E8L03_RS20530	COG2957	Belongs to the agmatine deiminase family
E8L03_RS20545	COG0616	signal peptide processing
E8L03_RS20555	COG0489	protein tyrosine kinase activity
E8L03_RS20560	COG2894	cell division
E8L03_RS20565	COG0489	protein tyrosine kinase activity
E8L03_RS20590	COG0375	protein maturation
E8L03_RS20605	COG0318	PFAM AMP-dependent synthetase and ligase
E8L03_RS20670	COG0347	Belongs to the P(II) protein family
E8L03_RS20690	COG0765	amino acid transport
E8L03_RS20700	COG2188	Transcriptional regulator
E8L03_RS20710	COG4948	Mandelate Racemase Muconate Lactonizing
E8L03_RS20725	COG2721	sulfolactate sulfo-lyase activity
E8L03_RS20730	COG2721	sulfolactate sulfo-lyase activity
E8L03_RS20745	COG2199	diguanylate cyclase activity
E8L03_RS20745	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E8L03_RS20750	COG2226	methyltransferase
E8L03_RS20760	COG2304	oxidoreductase activity
E8L03_RS20765	COG0745	RESPONSE REGULATOR receiver
E8L03_RS20770	COG2205	protein histidine kinase activity
E8L03_RS20780	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E8L03_RS20785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E8L03_RS20790	COG3959	Transketolase, thiamine diphosphate binding domain
E8L03_RS20795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E8L03_RS20820	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E8L03_RS20825	COG0217	transcriptional regulatory protein
E8L03_RS20830	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E8L03_RS20835	COG0632	four-way junction helicase activity
E8L03_RS20845	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant