locus-tag	class	description
DBW_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DBW_RS00020	COG0187	DNA topoisomerase II activity
DBW_RS00035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DBW_RS00050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DBW_RS00070	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DBW_RS00075	COG1469	GTP cyclohydrolase I activity
DBW_RS00085	COG0811	peptide transport
DBW_RS00100	COG0823	Involved in the tonB-independent uptake of proteins
DBW_RS00105	COG2885	chlorophyll binding
DBW_RS00130	COG4520	surface antigen
DBW_RS00155	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DBW_RS00155	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DBW_RS00155	COG1703	isobutyryl-CoA mutase activity
DBW_RS00160	COG2204	response regulator
DBW_RS00175	COG0559	Belongs to the binding-protein-dependent transport system permease family
DBW_RS00200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DBW_RS00205	COG1024	Enoyl-CoA hydratase
DBW_RS00210	COG2086	electron transfer activity
DBW_RS00215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DBW_RS00220	COG0183	Belongs to the thiolase family
DBW_RS00225	COG1250	3-hydroxyacyl-CoA dehydrogenase
DBW_RS00230	COG1024	Enoyl-CoA hydratase
DBW_RS00240	COG1960	acyl-CoA dehydrogenase activity
DBW_RS00250	COG1960	acyl-CoA dehydrogenase activity
DBW_RS00265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DBW_RS00270	COG1024	Enoyl-CoA hydratase
DBW_RS00290	COG0640	Transcriptional regulator
DBW_RS00295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DBW_RS00300	COG0798	PFAM Bile acid sodium symporter
DBW_RS00305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DBW_RS00310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DBW_RS00320	COG3328	transposase activity
DBW_RS00375	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DBW_RS00385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DBW_RS00390	COG0519	Catalyzes the synthesis of GMP from XMP
DBW_RS00390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DBW_RS00395	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DBW_RS00400	COG4149	molybdate abc transporter
DBW_RS00425	COG0725	ABC transporter, periplasmic molybdate-binding protein
DBW_RS00435	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
DBW_RS00440	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
DBW_RS00455	COG0701	Predicted permease
DBW_RS00460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DBW_RS00465	COG0531	amino acid
DBW_RS00470	COG4895	conserved protein (DUF2196)
DBW_RS00480	COG2154	pterin-4-alpha-carbinolamine dehydratase
DBW_RS00495	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
DBW_RS00505	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
DBW_RS00510	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
DBW_RS00515	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
DBW_RS00560	COG1002	Type II restriction enzyme, methylase subunits
DBW_RS00565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DBW_RS00595	COG1720	tRNA m6t6A37 methyltransferase activity
DBW_RS00600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DBW_RS00620	COG1064	alcohol dehydrogenase
DBW_RS00635	COG1959	2 iron, 2 sulfur cluster binding
DBW_RS00640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DBW_RS00650	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DBW_RS00655	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DBW_RS00660	COG4208	sulfate ABC transporter
DBW_RS00675	COG1151	hydroxylamine reductase activity
DBW_RS00680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DBW_RS00680	COG1116	anion transmembrane transporter activity
DBW_RS00685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DBW_RS00690	COG1116	anion transmembrane transporter activity
DBW_RS00715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DBW_RS00720	COG1116	anion transmembrane transporter activity
DBW_RS00735	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DBW_RS00745	COG0121	glutamine amidotransferase
DBW_RS00755	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DBW_RS00760	COG1104	cysteine desulfurase activity
DBW_RS00770	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DBW_RS00785	COG0398	Pfam SNARE associated Golgi protein
DBW_RS00815	COG1215	transferase activity, transferring glycosyl groups
DBW_RS00820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DBW_RS00825	COG1116	anion transmembrane transporter activity
DBW_RS00835	COG5012	cobalamin binding
DBW_RS00840	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DBW_RS00870	COG2205	protein histidine kinase activity
DBW_RS00875	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DBW_RS00880	COG3328	transposase activity
DBW_RS00885	COG0606	chelatase, subunit chli
DBW_RS00915	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DBW_RS00920	COG4191	Histidine kinase
DBW_RS00930	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DBW_RS00955	COG0697	spore germination
DBW_RS00975	COG2217	Heavy metal translocating P-type atpase
DBW_RS00990	COG3258	Cytochrome c
DBW_RS01000	COG2132	Multicopper oxidase
DBW_RS01005	COG0606	chelatase, subunit chli
DBW_RS01035	COG0785	Cytochrome C biogenesis protein
DBW_RS01040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DBW_RS01045	COG0347	Belongs to the P(II) protein family
DBW_RS01080	COG0606	chelatase, subunit chli
DBW_RS01105	COG3852	Histidine kinase
DBW_RS01110	COG2204	response regulator
DBW_RS01120	COG1138	Cytochrome C-type biogenesis protein
DBW_RS01135	COG1131	(ABC) transporter
DBW_RS01145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DBW_RS01185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DBW_RS01185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DBW_RS01190	COG0789	Transcriptional regulator
DBW_RS01210	COG0785	Cytochrome C biogenesis protein
DBW_RS01230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DBW_RS01235	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DBW_RS01240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DBW_RS01265	COG0577	efflux transmembrane transporter activity
DBW_RS01270	COG1136	(ABC) transporter
DBW_RS01275	COG0640	Transcriptional regulator
DBW_RS01285	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DBW_RS01290	COG4191	Histidine kinase
DBW_RS01300	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DBW_RS01335	COG2226	methyltransferase
DBW_RS01420	COG2608	mercury ion transmembrane transporter activity
DBW_RS01440	COG0606	chelatase, subunit chli
DBW_RS01470	COG1476	TRANSCRIPTIONal
DBW_RS01480	COG2135	peptidase activity
DBW_RS01495	COG0419	ATPase involved in DNA repair
DBW_RS01500	COG0420	3'-5' exonuclease activity
DBW_RS01515	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DBW_RS01580	COG0629	single-stranded DNA binding
DBW_RS01635	COG2003	Belongs to the UPF0758 family
DBW_RS01680	COG4974	Belongs to the 'phage' integrase family
DBW_RS01690	COG1525	nuclease
DBW_RS01715	COG3328	transposase activity
DBW_RS01860	COG2932	Transcriptional regulator
DBW_RS01875	COG0686	Belongs to the AlaDH PNT family
DBW_RS01880	COG0492	ferredoxin-NADP+ reductase activity
DBW_RS01895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DBW_RS01900	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DBW_RS01910	COG1420	regulation of RNA biosynthetic process
DBW_RS01915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DBW_RS01920	COG0443	Heat shock 70 kDa protein
DBW_RS01925	COG0484	heat shock protein binding
DBW_RS01940	COG1329	Transcriptional regulator
DBW_RS01945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DBW_RS01950	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DBW_RS01955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DBW_RS01970	COG0840	transmembrane signaling receptor activity
DBW_RS01975	COG2198	Histidine kinase
DBW_RS01975	COG0784	Response regulator, receiver
DBW_RS01975	COG0643	Histidine kinase
DBW_RS01980	COG2201	protein-glutamate methylesterase activity
DBW_RS01985	COG0215	cysteine-tRNA ligase activity
DBW_RS01995	COG0556	nucleotide-excision repair
DBW_RS02040	COG0189	ligase activity
DBW_RS02045	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DBW_RS02055	COG3264	Mechanosensitive ion channel
DBW_RS02055	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DBW_RS02065	COG3005	denitrification pathway
DBW_RS02075	COG0437	4 iron, 4 sulfur cluster binding
DBW_RS02105	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DBW_RS02110	COG0356	it plays a direct role in the translocation of protons across the membrane
DBW_RS02125	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DBW_RS02130	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DBW_RS02140	COG0539	negative regulation of cytoplasmic translation
DBW_RS02145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DBW_RS02150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DBW_RS02160	COG1278	Cold shock
DBW_RS02170	COG1024	Enoyl-CoA hydratase
DBW_RS02175	COG0745	RESPONSE REGULATOR receiver
DBW_RS02180	COG2205	protein histidine kinase activity
DBW_RS02185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DBW_RS02190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DBW_RS02195	COG1022	Amp-dependent synthetase and ligase
DBW_RS02200	COG1250	3-hydroxyacyl-CoA dehydrogenase
DBW_RS02200	COG1024	Enoyl-CoA hydratase
DBW_RS02205	COG0183	Belongs to the thiolase family
DBW_RS02210	COG1960	acyl-CoA dehydrogenase activity
DBW_RS02220	COG0446	pyridine nucleotide-disulphide oxidoreductase
DBW_RS02220	COG1902	pentaerythritol trinitrate reductase activity
DBW_RS02235	COG0789	Transcriptional regulator
DBW_RS02240	COG2181	nitrate reductase activity
DBW_RS02240	COG0247	lactate metabolic process
DBW_RS02245	COG2086	electron transfer activity
DBW_RS02250	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DBW_RS02270	COG4584	PFAM Integrase catalytic
DBW_RS02275	COG1484	DNA-dependent DNA replication
DBW_RS02280	COG3328	transposase activity
DBW_RS02300	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DBW_RS02320	COG4657	Part of a membrane complex involved in electron transport
DBW_RS02330	COG4656	Part of a membrane complex involved in electron transport
DBW_RS02335	COG4658	electron transport chain
DBW_RS02340	COG4659	FMN binding
DBW_RS02345	COG4660	Part of a membrane complex involved in electron transport
DBW_RS02350	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DBW_RS02390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DBW_RS02395	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DBW_RS02420	COG1007	ATP synthesis coupled electron transport
DBW_RS02425	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
DBW_RS02435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DBW_RS02440	COG1127	ABC transporter
DBW_RS02455	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DBW_RS02465	COG1131	(ABC) transporter
DBW_RS02480	COG0308	aminopeptidase N
DBW_RS02535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DBW_RS02540	COG0163	prenyltransferase activity
DBW_RS02545	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DBW_RS02565	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DBW_RS02570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DBW_RS02575	COG1194	a g-specific adenine glycosylase
DBW_RS02580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DBW_RS02600	COG0114	fumarate hydratase activity
DBW_RS02615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DBW_RS02660	COG0653	protein targeting
DBW_RS02665	COG0653	protein targeting
DBW_RS02690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DBW_RS02695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DBW_RS02700	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DBW_RS02700	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DBW_RS02700	COG1013	pyruvate-flavodoxin oxidoreductase activity
DBW_RS02700	COG0674	pyruvate-flavodoxin oxidoreductase activity
DBW_RS02710	COG1100	Small GTP-binding protein
DBW_RS02725	COG3158	transport of potassium into the cell
DBW_RS02730	COG5002	protein histidine kinase activity
DBW_RS02750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DBW_RS02765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DBW_RS02770	COG0569	domain protein
DBW_RS02785	COG1121	(ABC) transporter
DBW_RS02790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DBW_RS02800	COG1959	2 iron, 2 sulfur cluster binding
DBW_RS02810	COG1271	oxidase subunit
DBW_RS02815	COG1294	oxidase, subunit
DBW_RS02830	COG1047	Peptidyl-prolyl cis-trans
DBW_RS02845	COG1131	(ABC) transporter
DBW_RS02850	COG0842	Transport permease protein
DBW_RS02855	COG0842	Transport permease protein
DBW_RS02860	COG0647	UMP catabolic process
DBW_RS02870	COG1028	Short-chain dehydrogenase reductase Sdr
DBW_RS02875	COG0681	Belongs to the peptidase S26 family
DBW_RS02885	COG3328	transposase activity
DBW_RS02890	COG2234	aminopeptidase activity
DBW_RS02900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DBW_RS02905	COG1272	protein, Hemolysin III
DBW_RS02910	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DBW_RS02930	COG5002	protein histidine kinase activity
DBW_RS02935	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DBW_RS02945	COG0745	RESPONSE REGULATOR receiver
DBW_RS02950	COG5002	protein histidine kinase activity
DBW_RS02960	COG0573	inorganic phosphate transmembrane transporter activity
DBW_RS02965	COG0581	inorganic phosphate transmembrane transporter activity
DBW_RS02970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DBW_RS02975	COG0704	Plays a role in the regulation of phosphate uptake
DBW_RS02985	COG2391	methyltransferase activity
DBW_RS03000	COG2204	response regulator
DBW_RS03005	COG1278	Cold shock
DBW_RS03020	COG0542	response to heat
DBW_RS03025	COG0745	RESPONSE REGULATOR receiver
DBW_RS03035	COG0745	RESPONSE REGULATOR receiver
DBW_RS03040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DBW_RS03055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DBW_RS03060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DBW_RS03065	COG0038	chloride channel
DBW_RS03080	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DBW_RS03110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DBW_RS03115	COG0459	protein refolding
DBW_RS03135	COG2208	phosphoserine phosphatase activity
DBW_RS03140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DBW_RS03150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DBW_RS03150	COG0321	lipoyl(octanoyl) transferase activity
DBW_RS03185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DBW_RS03190	COG0617	tRNA 3'-terminal CCA addition
DBW_RS03210	COG0714	Associated with various cellular activities
DBW_RS03230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DBW_RS03240	COG0045	succinate-CoA ligase (ADP-forming) activity
DBW_RS03245	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DBW_RS03255	COG2132	Multicopper oxidase
DBW_RS03260	COG0242	peptide deformylase activity
DBW_RS03265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DBW_RS03275	COG0501	Belongs to the peptidase M48B family
DBW_RS03280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DBW_RS03280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DBW_RS03285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DBW_RS03300	COG0646	methionine synthase
DBW_RS03300	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DBW_RS03305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DBW_RS03340	COG3344	reverse transcriptase
DBW_RS03350	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DBW_RS03355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DBW_RS03360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DBW_RS03365	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DBW_RS03370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DBW_RS03395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DBW_RS03400	COG1129	ABC transporter
DBW_RS03400	COG0842	Transport permease protein
DBW_RS03405	COG0842	Transport permease protein
DBW_RS03410	COG1846	Transcriptional regulator
DBW_RS03435	COG3384	dioxygenase
DBW_RS03440	COG0655	NAD(P)H dehydrogenase (quinone) activity
DBW_RS03445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DBW_RS03470	COG0328	RNA-DNA hybrid ribonuclease activity
DBW_RS03485	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DBW_RS03485	COG0649	NAD binding
DBW_RS03495	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DBW_RS03505	COG1034	ATP synthesis coupled electron transport
DBW_RS03510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DBW_RS03515	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DBW_RS03525	COG0713	ATP synthesis coupled electron transport
DBW_RS03545	COG2319	Wd-40 repeat
DBW_RS03545	COG4249	Peptidase C14 caspase catalytic subunit p20
DBW_RS03550	COG2319	Wd-40 repeat
DBW_RS03550	COG4249	Peptidase C14 caspase catalytic subunit p20
DBW_RS03555	COG2319	Wd-40 repeat
DBW_RS03555	COG4249	Peptidase C14 caspase catalytic subunit p20
DBW_RS03575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DBW_RS03580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DBW_RS03585	COG0367	asparagine synthase
DBW_RS03645	COG3597	protein domain associated with
DBW_RS03650	COG1064	alcohol dehydrogenase
DBW_RS03665	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DBW_RS03690	COG3328	transposase activity
DBW_RS03730	COG1002	Type II restriction enzyme, methylase subunits
DBW_RS03740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DBW_RS03745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DBW_RS03750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DBW_RS03760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DBW_RS03785	COG4251	negative regulation of phosphorylation
DBW_RS03790	COG1040	competence protein
DBW_RS03795	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DBW_RS03810	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DBW_RS03815	COG0799	negative regulation of ribosome biogenesis
DBW_RS03820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DBW_RS03825	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DBW_RS03830	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DBW_RS03835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DBW_RS03840	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DBW_RS03845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DBW_RS03855	COG4181	ATPase activity
DBW_RS03865	COG1914	H( )-stimulated, divalent metal cation uptake system
DBW_RS03875	COG1530	ribonuclease E activity
DBW_RS03885	COG4191	Histidine kinase
DBW_RS03890	COG2204	response regulator
DBW_RS03895	COG0288	reversible hydration of carbon dioxide
DBW_RS03910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DBW_RS03920	COG0004	ammonium transporteR
DBW_RS03930	COG0069	glutamate synthase activity
DBW_RS03975	COG0129	dihydroxy-acid dehydratase activity
DBW_RS03985	COG0028	Belongs to the TPP enzyme family
DBW_RS03995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DBW_RS04010	COG0037	tRNA processing
DBW_RS04025	COG0745	RESPONSE REGULATOR receiver
DBW_RS04030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DBW_RS04035	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DBW_RS04040	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DBW_RS04045	COG0154	amidase activity
DBW_RS04050	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DBW_RS04055	COG3047	cAMP biosynthetic process
DBW_RS04055	COG2885	chlorophyll binding
DBW_RS04060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DBW_RS04065	COG1028	Short-chain dehydrogenase reductase Sdr
DBW_RS04075	COG0392	lysyltransferase activity
DBW_RS04090	COG0303	'Molybdopterin
DBW_RS04095	COG1763	Mo-molybdopterin cofactor biosynthetic process
DBW_RS04105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DBW_RS04130	COG0243	molybdopterin cofactor binding
DBW_RS04145	COG0488	(ABC) transporter
DBW_RS04165	COG0745	RESPONSE REGULATOR receiver
DBW_RS04190	COG2113	Glycine betaine
DBW_RS04195	COG4176	ABC-type proline glycine betaine transport system permease component
DBW_RS04200	COG4175	Glycine betaine
DBW_RS04205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DBW_RS04230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DBW_RS04230	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DBW_RS04235	COG0670	Belongs to the BI1 family
DBW_RS04255	COG3123	guanosine phosphorylase activity
DBW_RS04265	COG0513	Belongs to the DEAD box helicase family
DBW_RS04290	COG1278	Cold shock
DBW_RS04295	COG0058	SHG alpha-glucan phosphorylase activity
DBW_RS04300	COG3089	Belongs to the UPF0270 family
DBW_RS04335	COG2259	Doxx family
DBW_RS04350	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DBW_RS04365	COG2135	peptidase activity
DBW_RS04385	COG3422	double-strand break repair
DBW_RS04410	COG3328	transposase activity
DBW_RS04425	COG0436	Aminotransferase
DBW_RS04430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DBW_RS04435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DBW_RS04450	COG0165	Argininosuccinate lyase
DBW_RS04460	COG2816	NAD+ diphosphatase activity
DBW_RS04465	COG0137	argininosuccinate synthase activity
DBW_RS04475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DBW_RS04480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DBW_RS04485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DBW_RS04490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DBW_RS04495	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DBW_RS04500	COG5002	protein histidine kinase activity
DBW_RS04510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DBW_RS04515	COG2137	regulation of response to DNA damage stimulus
DBW_RS04525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DBW_RS04535	COG5002	protein histidine kinase activity
DBW_RS04540	COG1058	Belongs to the CinA family
DBW_RS04540	COG1546	Belongs to the CinA family
DBW_RS04545	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DBW_RS04550	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DBW_RS04555	COG1691	(AIR) carboxylase
DBW_RS04560	COG1674	ftsk spoiiie
DBW_RS04565	COG1968	undecaprenyl-diphosphatase activity
DBW_RS04570	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DBW_RS04600	COG1022	Amp-dependent synthetase and ligase
DBW_RS04605	COG0237	dephospho-CoA kinase activity
DBW_RS04615	COG1414	Transcriptional regulator
DBW_RS04630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DBW_RS04640	COG0585	pseudouridine synthase activity
DBW_RS04645	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DBW_RS04675	COG2204	response regulator
DBW_RS04680	COG3852	Histidine kinase
DBW_RS04685	COG0628	permease
DBW_RS04700	COG0322	excinuclease ABC activity
DBW_RS04720	COG5002	protein histidine kinase activity
DBW_RS04725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DBW_RS04730	COG5002	protein histidine kinase activity
DBW_RS04735	COG0017	Asparaginyl-tRNA synthetase
DBW_RS04740	COG1671	Belongs to the UPF0178 family
DBW_RS04755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DBW_RS04810	COG3328	transposase activity
DBW_RS04815	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DBW_RS04860	COG2165	general secretion pathway protein
DBW_RS04870	COG1459	type II secretion system
DBW_RS04875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DBW_RS04915	COG1730	sister chromatid segregation
DBW_RS04945	COG1127	ABC transporter
DBW_RS04950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DBW_RS04970	COG2205	protein histidine kinase activity
DBW_RS04975	COG0745	RESPONSE REGULATOR receiver
DBW_RS04985	COG0628	permease
DBW_RS04990	COG2239	Acts as a magnesium transporter
DBW_RS05000	COG1381	Involved in DNA repair and RecF pathway recombination
DBW_RS05005	COG0752	glycyl-tRNA synthetase alpha subunit
DBW_RS05010	COG0751	glycine-tRNA ligase activity
DBW_RS05015	COG0574	Belongs to the PEP-utilizing enzyme family
DBW_RS05015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DBW_RS05020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DBW_RS05030	COG1515	deoxyribonuclease V activity
DBW_RS05035	COG0179	Fumarylacetoacetate (FAA) hydrolase
DBW_RS05045	COG3328	transposase activity
DBW_RS05055	COG2860	membrane
DBW_RS05065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DBW_RS05080	COG3344	reverse transcriptase
DBW_RS05105	COG4771	TonB-dependent receptor
DBW_RS05125	COG0352	thiamine-phosphate diphosphorylase activity
DBW_RS05130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DBW_RS05135	COG2022	thiamine diphosphate biosynthetic process
DBW_RS05145	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DBW_RS05150	COG0535	radical SAM domain protein
DBW_RS05155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DBW_RS05165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DBW_RS05190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DBW_RS05200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DBW_RS05210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DBW_RS05215	COG2853	Lipoprotein
DBW_RS05220	COG2854	intermembrane phospholipid transfer
DBW_RS05225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DBW_RS05235	COG0484	heat shock protein binding
DBW_RS05250	COG0242	peptide deformylase activity
DBW_RS05255	COG3830	Belongs to the UPF0237 family
DBW_RS05280	COG1136	(ABC) transporter
DBW_RS05295	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DBW_RS05300	COG0426	domain, Protein
DBW_RS05325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DBW_RS05330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DBW_RS05340	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DBW_RS05345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DBW_RS05360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DBW_RS05365	COG0442	prolyl-tRNA aminoacylation
DBW_RS05375	COG0284	orotidine-5'-phosphate decarboxylase activity
DBW_RS05380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DBW_RS05405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DBW_RS05410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DBW_RS05430	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DBW_RS05435	COG0081	regulation of translation
DBW_RS05440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DBW_RS05445	COG0222	ribosome binding
DBW_RS05450	COG0085	RNA polymerase activity
DBW_RS05455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DBW_RS05460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DBW_RS05465	COG0049	tRNA binding
DBW_RS05470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DBW_RS05475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DBW_RS05480	COG0051	transcription antitermination factor activity, RNA binding
DBW_RS05485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DBW_RS05490	COG0088	Forms part of the polypeptide exit tunnel
DBW_RS05495	COG0089	rRNA binding
DBW_RS05500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DBW_RS05505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DBW_RS05510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DBW_RS05515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DBW_RS05520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DBW_RS05525	COG0255	Belongs to the universal ribosomal protein uL29 family
DBW_RS05530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DBW_RS05535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DBW_RS05540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DBW_RS05545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DBW_RS05550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DBW_RS05555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DBW_RS05560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DBW_RS05570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DBW_RS05575	COG1841	ribosomal large subunit assembly
DBW_RS05580	COG0200	Binds to the 23S rRNA
DBW_RS05585	COG0201	protein transport
DBW_RS05590	COG0563	adenylate kinase activity
DBW_RS05600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DBW_RS05605	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DBW_RS05610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DBW_RS05615	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DBW_RS05620	COG0202	RNA polymerase activity
DBW_RS05625	COG0203	ribosomal protein L17
DBW_RS05645	COG0708	Exodeoxyribonuclease III
DBW_RS05650	COG2345	Transcriptional regulator
DBW_RS05670	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
DBW_RS05680	COG2801	Transposase and inactivated derivatives
DBW_RS05685	COG3328	transposase activity
DBW_RS05710	COG3328	transposase activity
DBW_RS05720	COG3328	transposase activity
DBW_RS05745	COG0653	protein targeting
DBW_RS05750	COG4584	PFAM Integrase catalytic
DBW_RS05755	COG1484	DNA-dependent DNA replication
DBW_RS05775	COG2361	Protein of unknown function DUF86
DBW_RS05790	COG0700	Nucleoside recognition
DBW_RS05795	COG2715	membrane protein required for spore maturation
DBW_RS05800	COG1619	proteins homologs of microcin C7 resistance protein MccF
DBW_RS05815	COG1752	Esterase of the alpha-beta hydrolase superfamily
DBW_RS05835	COG1793	dna ligase
DBW_RS05850	COG2716	regulation of RNA biosynthetic process
DBW_RS05865	COG4520	surface antigen
DBW_RS05875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DBW_RS05885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DBW_RS05890	COG0134	indole-3-glycerol-phosphate synthase activity
DBW_RS05895	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DBW_RS05900	COG0135	phosphoribosylanthranilate isomerase activity
DBW_RS05910	COG0513	Belongs to the DEAD box helicase family
DBW_RS05920	COG1573	uracil-dna glycosylase
DBW_RS05925	COG0159	tryptophan synthase activity
DBW_RS05935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DBW_RS05945	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DBW_RS05950	COG1596	polysaccharide export
DBW_RS05950	COG1555	photosystem II stabilization
DBW_RS05955	COG3344	reverse transcriptase
DBW_RS05960	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DBW_RS05985	COG3344	reverse transcriptase
DBW_RS05995	COG0037	tRNA processing
DBW_RS06000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DBW_RS06005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DBW_RS06010	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DBW_RS06020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DBW_RS06025	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DBW_RS06030	COG0736	holo-[acyl-carrier-protein] synthase activity
DBW_RS06035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DBW_RS06035	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DBW_RS06040	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DBW_RS06040	COG0617	tRNA 3'-terminal CCA addition
DBW_RS06040	COG0517	IMP dehydrogenase activity
DBW_RS06045	COG0802	atpase or kinase
DBW_RS06050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DBW_RS06055	COG0527	aspartate kinase activity
DBW_RS06060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DBW_RS06070	COG3344	reverse transcriptase
DBW_RS06100	COG0583	DNA-binding transcription factor activity
DBW_RS06110	COG2814	Major facilitator Superfamily
DBW_RS06135	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DBW_RS06145	COG0519	Catalyzes the synthesis of GMP from XMP
DBW_RS06185	COG0667	Aldo Keto reductase
DBW_RS06190	COG0420	3'-5' exonuclease activity
DBW_RS06195	COG0419	ATPase involved in DNA repair
DBW_RS06205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DBW_RS06210	COG0022	dehydrogenase e1 component
DBW_RS06210	COG0508	dehydrogenase complex catalyzes the overall conversion of
DBW_RS06215	COG0508	dehydrogenase complex catalyzes the overall conversion of
DBW_RS06220	COG1067	ATP-dependent peptidase activity
DBW_RS06225	COG3852	Histidine kinase
DBW_RS06245	COG0589	response to stress
DBW_RS06265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DBW_RS06275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DBW_RS06280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DBW_RS06285	COG0193	aminoacyl-tRNA hydrolase activity
DBW_RS06290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DBW_RS06305	COG0360	Binds together with S18 to 16S ribosomal RNA
DBW_RS06310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DBW_RS06320	COG0359	binds to the 23S rRNA
DBW_RS06325	COG0305	Participates in initiation and elongation during chromosome replication
DBW_RS06350	COG4771	TonB-dependent receptor
DBW_RS06360	COG0784	Response regulator, receiver
DBW_RS06360	COG2205	protein histidine kinase activity
DBW_RS06360	COG5002	protein histidine kinase activity
DBW_RS06365	COG2204	response regulator
DBW_RS06370	COG4191	Histidine kinase
DBW_RS06375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DBW_RS06385	COG2226	methyltransferase
DBW_RS06400	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DBW_RS06410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DBW_RS06435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DBW_RS06455	COG0521	Mo-molybdopterin cofactor biosynthetic process
DBW_RS06475	COG0318	PFAM AMP-dependent synthetase and ligase
DBW_RS06485	COG3706	GGDEF domain
DBW_RS06520	COG1518	maintenance of DNA repeat elements
DBW_RS06530	COG1942	4-Oxalocrotonate Tautomerase
DBW_RS06540	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DBW_RS06560	COG1012	belongs to the aldehyde dehydrogenase family
DBW_RS06565	COG4221	oxidoreductase activity
DBW_RS06580	COG3852	Histidine kinase
DBW_RS06590	COG0004	ammonium transporteR
DBW_RS06600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DBW_RS06610	COG0483	inositol monophosphate 1-phosphatase activity
DBW_RS06625	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DBW_RS06635	COG1013	pyruvate-flavodoxin oxidoreductase activity
DBW_RS06640	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DBW_RS06640	COG0674	pyruvate-flavodoxin oxidoreductase activity
DBW_RS06650	COG0039	L-malate dehydrogenase activity
DBW_RS06665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DBW_RS06670	COG0124	histidyl-tRNA synthetase
DBW_RS06685	COG3706	GGDEF domain
DBW_RS06690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DBW_RS06715	COG0840	transmembrane signaling receptor activity
DBW_RS06725	COG0745	RESPONSE REGULATOR receiver
DBW_RS06730	COG2198	Histidine kinase
DBW_RS06730	COG0643	Histidine kinase
DBW_RS06735	COG0840	transmembrane signaling receptor activity
DBW_RS06735	COG3290	protein histidine kinase activity
DBW_RS06740	COG0835	chemotaxis
DBW_RS06750	COG2201	protein-glutamate methylesterase activity
DBW_RS06760	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DBW_RS06770	COG0488	(ABC) transporter
DBW_RS06775	COG1049	propionate catabolic process, 2-methylcitrate cycle
DBW_RS06785	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DBW_RS06800	COG3344	reverse transcriptase
DBW_RS06805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DBW_RS06810	COG4597	amino acid ABC transporter
DBW_RS06815	COG0765	amino acid transport
DBW_RS06820	COG1126	abc transporter atp-binding protein
DBW_RS06825	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DBW_RS06825	COG0617	tRNA 3'-terminal CCA addition
DBW_RS06825	COG0517	IMP dehydrogenase activity
DBW_RS06835	COG4651	solute:proton antiporter activity
DBW_RS06835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DBW_RS06845	COG3530	Putative quorum-sensing-regulated virulence factor
DBW_RS06850	COG2501	S4 domain
DBW_RS06865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DBW_RS06875	COG0791	NLP P60 protein
DBW_RS06880	COG2985	domain, Protein
DBW_RS06880	COG0569	domain protein
DBW_RS06905	COG3132	Protein of unknown function, DUF480
DBW_RS06915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DBW_RS06935	COG1309	transcriptional regulator
DBW_RS06940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DBW_RS06965	COG3852	Histidine kinase
DBW_RS06970	COG2204	response regulator
DBW_RS06975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DBW_RS06980	COG4968	Prepilin-type N-terminal cleavage methylation domain
DBW_RS07010	COG4966	pilus assembly protein PilW
DBW_RS07030	COG0557	exoribonuclease II activity
DBW_RS07035	COG0196	riboflavin kinase activity
DBW_RS07040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DBW_RS07045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DBW_RS07055	COG1459	type II secretion system
DBW_RS07060	COG3852	Histidine kinase
DBW_RS07065	COG2204	response regulator
DBW_RS07070	COG4968	Prepilin-type N-terminal cleavage methylation domain
DBW_RS07080	COG1131	(ABC) transporter
DBW_RS07135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DBW_RS07140	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DBW_RS07155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DBW_RS07160	COG0006	proline dipeptidase activity
DBW_RS07165	COG0511	ligase activity, forming carbon-carbon bonds
DBW_RS07170	COG0439	Biotin carboxylase
DBW_RS07175	COG0095	Lipoate-protein ligase
DBW_RS07210	COG2078	PFAM AMMECR1 domain protein
DBW_RS07215	COG1217	gtp-binding protein TYPA
DBW_RS07220	COG0501	Belongs to the peptidase M48B family
DBW_RS07230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DBW_RS07235	COG2204	response regulator
DBW_RS07245	COG0587	DNA-directed DNA polymerase activity
DBW_RS07255	COG0516	GMP reductase activity
DBW_RS07255	COG0517	IMP dehydrogenase activity
DBW_RS07260	COG0519	Catalyzes the synthesis of GMP from XMP
DBW_RS07260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DBW_RS07265	COG0671	phosphoesterase, PA-phosphatase related
DBW_RS07280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DBW_RS07285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DBW_RS07290	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DBW_RS07295	COG2089	acid synthase
DBW_RS07305	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DBW_RS07310	COG1083	cytidylyl-transferase
DBW_RS07375	COG1086	Polysaccharide biosynthesis protein
DBW_RS07385	COG3328	transposase activity
DBW_RS07405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DBW_RS07415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DBW_RS07425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DBW_RS07450	COG0424	maF-like protein
DBW_RS07455	COG0587	DNA-directed DNA polymerase activity
DBW_RS07460	COG0825	malonyl-CoA metabolic process
DBW_RS07465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DBW_RS07475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DBW_RS07485	COG1484	DNA-dependent DNA replication
DBW_RS07490	COG4584	PFAM Integrase catalytic
DBW_RS07495	COG3328	transposase activity
DBW_RS07500	COG3328	transposase activity
DBW_RS07555	COG3549	Plasmid maintenance system killer
DBW_RS07580	COG3829	transcription factor binding
DBW_RS07580	COG3290	protein histidine kinase activity
DBW_RS07600	COG1129	ABC transporter
DBW_RS07605	COG0410	ABC transporter
DBW_RS07610	COG1454	alcohol dehydrogenase
DBW_RS07620	COG1942	4-Oxalocrotonate Tautomerase
DBW_RS07625	COG0824	Thioesterase
DBW_RS07630	COG2204	response regulator
DBW_RS07635	COG0471	metal ion transport
DBW_RS07640	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DBW_RS07655	COG0205	6-phosphofructokinase activity
DBW_RS07660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DBW_RS07665	COG0612	Peptidase, M16
DBW_RS07670	COG0612	Peptidase, M16
DBW_RS07675	COG2095	MarC family integral membrane protein
DBW_RS07700	COG1959	2 iron, 2 sulfur cluster binding
DBW_RS07700	COG1295	ribonuclease BN
DBW_RS07705	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DBW_RS07710	COG0700	Nucleoside recognition
DBW_RS07715	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DBW_RS07720	COG1942	4-Oxalocrotonate Tautomerase
DBW_RS07730	COG2217	Heavy metal translocating P-type atpase
DBW_RS07745	COG0860	N-Acetylmuramoyl-L-alanine amidase
DBW_RS07755	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DBW_RS07765	COG0702	epimerase
DBW_RS07770	COG0729	surface antigen
DBW_RS07780	COG0105	UTP biosynthetic process
DBW_RS07785	COG1696	Membrane protein involved in D-alanine export
DBW_RS07795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DBW_RS07800	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DBW_RS07820	COG0745	RESPONSE REGULATOR receiver
DBW_RS07830	COG2204	response regulator
DBW_RS07835	COG0589	response to stress
DBW_RS07840	COG4191	Histidine kinase
DBW_RS07845	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DBW_RS07850	COG3481	metal-dependent phosphohydrolase, HD sub domain
DBW_RS07855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DBW_RS07860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DBW_RS07870	COG1573	uracil-dna glycosylase
DBW_RS07875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DBW_RS07880	COG0390	transport system, permease component
DBW_RS07885	COG0668	transmembrane transport
DBW_RS07890	COG2204	response regulator
DBW_RS07900	COG0330	HflC and HflK could
DBW_RS07905	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DBW_RS07935	COG0084	hydrolase, TatD family'
DBW_RS07940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DBW_RS07940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DBW_RS07945	COG1774	PSP1 C-terminal conserved region
DBW_RS07955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DBW_RS07960	COG0571	ribonuclease III activity
DBW_RS07970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DBW_RS07975	COG1160	GTP binding
DBW_RS07980	COG0745	RESPONSE REGULATOR receiver
DBW_RS07985	COG0745	RESPONSE REGULATOR receiver
DBW_RS07990	COG2198	Histidine kinase
DBW_RS07990	COG0643	Histidine kinase
DBW_RS07995	COG3267	Type II secretory pathway component ExeA
DBW_RS07995	COG3409	Peptidoglycan-binding domain 1 protein
DBW_RS08005	COG0745	RESPONSE REGULATOR receiver
DBW_RS08010	COG0835	chemotaxis
DBW_RS08025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DBW_RS08030	COG2201	protein-glutamate methylesterase activity
DBW_RS08040	COG0745	RESPONSE REGULATOR receiver
DBW_RS08045	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DBW_RS08050	COG0495	leucyl-tRNA aminoacylation
DBW_RS08065	COG0268	Binds directly to 16S ribosomal RNA
DBW_RS08075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DBW_RS08080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DBW_RS08095	COG2873	o-acetylhomoserine
DBW_RS08100	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DBW_RS08110	COG3344	reverse transcriptase
DBW_RS08115	COG2315	Protein conserved in bacteria
DBW_RS08120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DBW_RS08130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DBW_RS08185	COG0174	glutamine synthetase
DBW_RS08195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DBW_RS08195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DBW_RS08210	COG0280	phosphate acetyltransferase
DBW_RS08210	COG0281	malic enzyme
DBW_RS08230	COG0811	peptide transport
DBW_RS08235	COG0848	biopolymer transport protein
DBW_RS08250	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DBW_RS08260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DBW_RS08265	COG0860	N-Acetylmuramoyl-L-alanine amidase
DBW_RS08280	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DBW_RS08295	COG0674	pyruvate-flavodoxin oxidoreductase activity
DBW_RS08300	COG1013	pyruvate-flavodoxin oxidoreductase activity
DBW_RS08340	COG4520	surface antigen
DBW_RS08360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DBW_RS08375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DBW_RS08385	COG0779	Required for maturation of 30S ribosomal subunits
DBW_RS08390	COG0195	Participates in both transcription termination and antitermination
DBW_RS08400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DBW_RS08405	COG1550	Protein conserved in bacteria
DBW_RS08410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DBW_RS08415	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DBW_RS08420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DBW_RS08425	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DBW_RS08435	COG1185	polyribonucleotide nucleotidyltransferase activity
DBW_RS08440	COG0612	Peptidase, M16
DBW_RS08445	COG0756	dUTP diphosphatase activity
DBW_RS08450	COG2921	Belongs to the UPF0250 family
DBW_RS08455	COG0009	L-threonylcarbamoyladenylate synthase
DBW_RS08485	COG0149	triose-phosphate isomerase activity
DBW_RS08490	COG0126	phosphoglycerate kinase activity
DBW_RS08500	COG2205	protein histidine kinase activity
DBW_RS08505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DBW_RS08510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DBW_RS08515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DBW_RS08520	COG0047	phosphoribosylformylglycinamidine synthase activity
DBW_RS08525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DBW_RS08530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DBW_RS08575	COG1028	Short-chain dehydrogenase reductase Sdr
DBW_RS08590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DBW_RS08595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DBW_RS08635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DBW_RS08665	COG1032	radical SAM domain protein
DBW_RS08670	COG1216	Glycosyl transferase, family 2
DBW_RS08680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DBW_RS08685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DBW_RS08710	COG1131	(ABC) transporter
DBW_RS08715	COG0842	Transport permease protein
DBW_RS08725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DBW_RS08730	COG1032	radical SAM domain protein
DBW_RS08755	COG0741	lytic transglycosylase activity
DBW_RS08760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DBW_RS08780	COG2361	Protein of unknown function DUF86
DBW_RS08790	COG1234	tRNA 3'-trailer cleavage
DBW_RS08800	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DBW_RS08820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DBW_RS08825	COG0537	adenosine 5'-monophosphoramidase activity
DBW_RS08830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DBW_RS08840	COG2992	FlgJ-related protein
DBW_RS08855	COG3956	TIGRFAM MazG family protein
DBW_RS08865	COG0416	fatty acid biosynthetic process
DBW_RS08870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DBW_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
DBW_RS08885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DBW_RS08890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DBW_RS08895	COG0698	ribose 5-phosphate isomerase
DBW_RS08900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DBW_RS08905	COG2131	deaminase
DBW_RS08910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DBW_RS08915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DBW_RS08915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DBW_RS08925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DBW_RS08925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DBW_RS08930	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DBW_RS08935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DBW_RS08950	COG2067	long-chain fatty acid transport protein
DBW_RS08970	COG0318	PFAM AMP-dependent synthetase and ligase
DBW_RS08980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DBW_RS08985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DBW_RS08990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DBW_RS08995	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DBW_RS09000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DBW_RS09005	COG0072	phenylalanine-tRNA ligase activity
DBW_RS09020	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DBW_RS09025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DBW_RS09060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DBW_RS09130	COG0517	IMP dehydrogenase activity
DBW_RS09130	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DBW_RS09130	COG0617	tRNA 3'-terminal CCA addition
DBW_RS09140	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DBW_RS09150	COG1414	Transcriptional regulator
DBW_RS09170	COG3267	Type II secretory pathway component ExeA
DBW_RS09170	COG3409	Peptidoglycan-binding domain 1 protein
DBW_RS09210	COG0577	efflux transmembrane transporter activity
DBW_RS09210	COG1136	(ABC) transporter
DBW_RS09215	COG1136	(ABC) transporter
DBW_RS09230	COG3852	Histidine kinase
DBW_RS09235	COG2204	response regulator
DBW_RS09245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DBW_RS09250	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DBW_RS09290	COG1074	ATP-dependent DNA helicase activity
DBW_RS09295	COG1285	pathogenesis
DBW_RS09325	COG2204	response regulator
DBW_RS09330	COG4191	Histidine kinase
DBW_RS09335	COG3409	Peptidoglycan-binding domain 1 protein
DBW_RS09335	COG3267	Type II secretory pathway component ExeA
DBW_RS09355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DBW_RS09380	COG0776	regulation of translation
DBW_RS09395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DBW_RS09405	COG1283	sodium-dependent phosphate transmembrane transporter activity
DBW_RS09410	COG0248	Ppx GppA phosphatase
DBW_RS09425	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DBW_RS09450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DBW_RS09460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DBW_RS09465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DBW_RS09470	COG0505	Belongs to the CarA family
DBW_RS09480	COG0540	Belongs to the ATCase OTCase family
DBW_RS09485	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DBW_RS09495	COG0481	GTPase activity
DBW_RS09500	COG0784	Response regulator, receiver
DBW_RS09500	COG2205	protein histidine kinase activity
DBW_RS09500	COG5002	protein histidine kinase activity
DBW_RS09505	COG0346	lactoylglutathione lyase activity
DBW_RS09510	COG0784	Response regulator, receiver
DBW_RS09520	COG1534	Rna-binding protein
DBW_RS09525	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DBW_RS09530	COG0742	ribosomal rna small subunit methyltransferase
DBW_RS09535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DBW_RS09555	COG0602	queuosine metabolic process
DBW_RS09560	COG0720	synthase
DBW_RS09565	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DBW_RS09580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DBW_RS09580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DBW_RS09590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DBW_RS09595	COG2827	Endonuclease containing a URI domain
DBW_RS09600	COG3012	SEC-C Motif Domain Protein
DBW_RS09605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DBW_RS09645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DBW_RS09655	COG3344	reverse transcriptase
DBW_RS09665	COG0617	tRNA 3'-terminal CCA addition
DBW_RS09675	COG0679	Auxin Efflux Carrier
DBW_RS09700	COG3842	ATPase activity
DBW_RS09705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DBW_RS09730	COG3344	reverse transcriptase
DBW_RS09745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DBW_RS09750	COG1355	regulation of microtubule-based process
DBW_RS09755	COG0730	response to heat
DBW_RS09765	COG1403	HNH endonuclease
DBW_RS09810	COG1484	DNA-dependent DNA replication
DBW_RS09815	COG4584	PFAM Integrase catalytic
DBW_RS09940	COG2852	Protein conserved in bacteria
DBW_RS09965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DBW_RS09980	COG0076	glutamate decarboxylase activity
DBW_RS09985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DBW_RS09990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DBW_RS10000	COG2902	Dehydrogenase
DBW_RS10005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DBW_RS10010	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DBW_RS10020	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DBW_RS10025	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DBW_RS10105	COG2204	response regulator
DBW_RS10110	COG3706	GGDEF domain
DBW_RS10115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DBW_RS10120	COG3328	transposase activity
DBW_RS10130	COG3328	transposase activity
DBW_RS10150	COG3239	Fatty acid desaturase
DBW_RS10170	COG1335	isochorismatase
DBW_RS10185	COG3047	cAMP biosynthetic process
DBW_RS10190	COG2824	Alkylphosphonate utilization operon protein PhnA
DBW_RS10195	COG0505	Belongs to the CarA family
DBW_RS10215	COG1720	tRNA m6t6A37 methyltransferase activity
DBW_RS10245	COG0861	Integral membrane protein TerC family
DBW_RS10260	COG2204	response regulator
DBW_RS10265	COG4191	Histidine kinase
DBW_RS10275	COG1376	ErfK ybiS ycfS ynhG family protein
DBW_RS10280	COG3034	peptidoglycan biosynthetic process
DBW_RS10305	COG2270	Major facilitator Superfamily
DBW_RS10310	COG0564	pseudouridine synthase activity
DBW_RS10315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DBW_RS10320	COG0482	sulfurtransferase activity
DBW_RS10325	COG0822	iron-sulfur transferase activity
DBW_RS10335	COG1959	2 iron, 2 sulfur cluster binding
DBW_RS10340	COG1045	serine acetyltransferase
DBW_RS10345	COG2205	protein histidine kinase activity
DBW_RS10350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DBW_RS10370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DBW_RS10380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DBW_RS10415	COG2132	Multicopper oxidase
DBW_RS10415	COG2132	Multicopper oxidase
DBW_RS10435	COG1404	Belongs to the peptidase S8 family
DBW_RS10440	COG2204	response regulator
DBW_RS10445	COG4191	Histidine kinase
DBW_RS10445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DBW_RS10460	COG0601	transmembrane transport
DBW_RS10495	COG2208	phosphoserine phosphatase activity
DBW_RS10510	COG0546	phosphoglycolate phosphatase activity
DBW_RS10515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DBW_RS10520	COG0564	pseudouridine synthase activity
DBW_RS10530	COG0776	regulation of translation
DBW_RS10535	COG0616	signal peptide processing
DBW_RS10540	COG0539	negative regulation of cytoplasmic translation
DBW_RS10540	COG2183	response to ionizing radiation
DBW_RS10545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DBW_RS10550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DBW_RS10555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DBW_RS10560	COG0287	Prephenate dehydrogenase
DBW_RS10565	COG1605	Chorismate mutase
DBW_RS10565	COG0077	Prephenate dehydratase
DBW_RS10570	COG0436	Aminotransferase
DBW_RS10575	COG2116	formate transmembrane transporter activity
DBW_RS10580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DBW_RS10580	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DBW_RS10595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DBW_RS10600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DBW_RS10605	COG1862	Preprotein translocase
DBW_RS10610	COG0343	queuine tRNA-ribosyltransferase activity
DBW_RS10615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DBW_RS10635	COG1032	radical SAM domain protein
DBW_RS10645	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DBW_RS10650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DBW_RS10655	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DBW_RS10660	COG0101	tRNA pseudouridine synthase activity
DBW_RS10665	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DBW_RS10675	COG0473	3-isopropylmalate dehydrogenase activity
DBW_RS10695	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DBW_RS10700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DBW_RS10705	COG0688	phosphatidylethanolamine metabolic process
DBW_RS10710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DBW_RS10715	COG0440	acetolactate synthase activity
DBW_RS10720	COG0028	Belongs to the TPP enzyme family
DBW_RS10725	COG0129	dihydroxy-acid dehydratase activity
DBW_RS10740	COG0750	zinc metalloprotease
DBW_RS10745	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DBW_RS10750	COG4589	Belongs to the CDS family
DBW_RS10755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DBW_RS10765	COG0233	cytoplasmic translational termination
DBW_RS10770	COG0528	UMP kinase activity
DBW_RS10775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DBW_RS10780	COG0052	Belongs to the universal ribosomal protein uS2 family
DBW_RS10805	COG2226	methyltransferase
DBW_RS10815	COG0463	Glycosyl transferase, family 2
DBW_RS10820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DBW_RS10825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DBW_RS10835	COG3716	PTS system mannose fructose sorbose family IID component
DBW_RS10845	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DBW_RS10855	COG1660	Displays ATPase and GTPase activities
DBW_RS10860	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DBW_RS10865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DBW_RS10875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DBW_RS10895	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DBW_RS10900	COG0517	IMP dehydrogenase activity
DBW_RS10900	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DBW_RS10905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DBW_RS10910	COG0504	CTP synthase activity
DBW_RS10915	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DBW_RS10920	COG0433	COG0433 Predicted ATPase
DBW_RS10930	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DBW_RS10940	COG0785	Cytochrome C biogenesis protein
DBW_RS10945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DBW_RS10960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DBW_RS10965	COG2204	response regulator
DBW_RS10970	COG4191	Histidine kinase
DBW_RS11005	COG1151	hydroxylamine reductase activity
DBW_RS11010	COG0668	transmembrane transport
DBW_RS11055	COG0778	Nitroreductase
DBW_RS11065	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DBW_RS11070	COG0033	Phosphoglucomutase
DBW_RS11085	COG1346	cytolysis
DBW_RS11090	COG1380	Effector of murein hydrolase LrgA
DBW_RS11105	COG1923	regulation of RNA biosynthetic process
DBW_RS11110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DBW_RS11115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DBW_RS11120	COG3409	Peptidoglycan-binding domain 1 protein
DBW_RS11120	COG3267	Type II secretory pathway component ExeA
DBW_RS11130	COG1187	pseudouridine synthase activity
DBW_RS11135	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DBW_RS11140	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DBW_RS11145	COG1994	Peptidase M50
DBW_RS11150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DBW_RS11150	COG0617	tRNA 3'-terminal CCA addition
DBW_RS11150	COG3620	sequence-specific DNA binding
DBW_RS11170	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DBW_RS11175	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DBW_RS11190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DBW_RS11200	COG0438	transferase activity, transferring glycosyl groups
DBW_RS11205	COG0561	phosphatase activity
DBW_RS11205	COG3100	YcgL domain-containing protein
DBW_RS11235	COG3344	reverse transcriptase
DBW_RS11240	COG1758	RNA polymerase activity
DBW_RS11245	COG0194	GDP metabolic process
DBW_RS11250	COG1561	YicC-like family, N-terminal region
DBW_RS11260	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DBW_RS11265	COG1091	dTDP-4-dehydrorhamnose reductase activity
DBW_RS11280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DBW_RS11285	COG0463	Glycosyl transferase, family 2
DBW_RS11295	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DBW_RS11295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DBW_RS11305	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DBW_RS11320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DBW_RS11350	COG0463	Glycosyl transferase, family 2
DBW_RS11350	COG1216	Glycosyl transferase, family 2
DBW_RS11355	COG0297	glycogen (starch) synthase activity
DBW_RS11365	COG1663	tetraacyldisaccharide 4'-kinase activity
DBW_RS11370	COG1519	Transferase
DBW_RS11380	COG1132	(ABC) transporter
DBW_RS11385	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DBW_RS11395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DBW_RS11400	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DBW_RS11410	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DBW_RS11415	COG1136	(ABC) transporter
DBW_RS11425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DBW_RS11435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DBW_RS11440	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DBW_RS11450	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DBW_RS11455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DBW_RS11460	COG1480	7TM receptor with intracellular HD hydrolase
DBW_RS11470	COG0148	phosphopyruvate hydratase activity
DBW_RS11495	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DBW_RS11500	COG1053	succinate dehydrogenase
DBW_RS11510	COG0343	queuine tRNA-ribosyltransferase activity
DBW_RS11520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DBW_RS11525	COG1970	mechanosensitive ion channel activity
DBW_RS11535	COG3852	Histidine kinase
DBW_RS11545	COG0142	geranyltranstransferase activity
DBW_RS11550	COG4191	Histidine kinase
DBW_RS11555	COG3278	Belongs to the heme-copper respiratory oxidase family
DBW_RS11580	COG2217	Heavy metal translocating P-type atpase
DBW_RS11610	COG1181	Belongs to the D-alanine--D-alanine ligase family
DBW_RS11615	COG1181	Belongs to the D-alanine--D-alanine ligase family
DBW_RS11635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DBW_RS11640	COG0446	pyridine nucleotide-disulphide oxidoreductase
DBW_RS11650	COG1024	Enoyl-CoA hydratase
DBW_RS11650	COG1250	3-hydroxyacyl-CoA dehydrogenase
DBW_RS11670	COG1659	Linocin_M18 bacteriocin protein
DBW_RS11715	COG2308	Evidence 4 Homologs of previously reported genes of
DBW_RS11740	COG1331	Highly conserved protein containing a thioredoxin domain
DBW_RS11745	COG0517	IMP dehydrogenase activity
DBW_RS11745	COG1227	inorganic diphosphatase activity
DBW_RS11760	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DBW_RS11765	COG2226	methyltransferase
DBW_RS11770	COG2267	carboxylic ester hydrolase activity
DBW_RS11775	COG0156	8-amino-7-oxononanoate synthase activity
DBW_RS11780	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
DBW_RS11795	COG2204	response regulator
DBW_RS11800	COG1238	metal cluster binding
DBW_RS11810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DBW_RS11820	COG1722	exodeoxyribonuclease VII activity
DBW_RS11825	COG1196	nuclear chromosome segregation
DBW_RS11825	COG0741	lytic transglycosylase activity
DBW_RS11825	COG0739	heme binding
DBW_RS11830	COG1570	exodeoxyribonuclease VII activity
DBW_RS11835	COG1192	Involved in chromosome partitioning
DBW_RS11840	COG2861	carbohydrate metabolic process
DBW_RS11845	COG0793	Belongs to the peptidase S41A family
DBW_RS11855	COG2177	Part of the ABC transporter FtsEX involved in
DBW_RS11860	COG2884	Cell division ATP-binding protein ftsE
DBW_RS11875	COG4796	Type ii and iii secretion system protein
DBW_RS11900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DBW_RS11905	COG1459	type II secretion system
DBW_RS11925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DBW_RS11950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DBW_RS11955	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DBW_RS11960	COG0740	serine-type endopeptidase activity
DBW_RS11965	COG0544	peptidyl-prolyl cis-trans isomerase activity
DBW_RS12000	COG0011	TIGRFAM Protein of
DBW_RS12010	COG1643	Atp-dependent helicase
DBW_RS12020	COG2195	Cleaves the N-terminal amino acid of tripeptides
DBW_RS12035	COG1388	LysM domain
DBW_RS12035	COG0791	NLP P60 protein
DBW_RS12060	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DBW_RS12080	COG0577	efflux transmembrane transporter activity
DBW_RS12080	COG1136	(ABC) transporter
DBW_RS12090	COG1136	(ABC) transporter
DBW_RS12090	COG0577	efflux transmembrane transporter activity
DBW_RS12115	COG2885	chlorophyll binding
DBW_RS12135	COG1993	acr, cog1993
DBW_RS12140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DBW_RS12145	COG0166	Belongs to the GPI family
DBW_RS12150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DBW_RS12165	COG4584	PFAM Integrase catalytic
DBW_RS12170	COG1484	DNA-dependent DNA replication
DBW_RS12205	COG0714	Associated with various cellular activities
DBW_RS12220	COG2304	oxidoreductase activity
DBW_RS12240	COG0427	acetyl-CoA hydrolase
DBW_RS12245	COG2204	response regulator
DBW_RS12270	COG3188	usher protein
DBW_RS12285	COG0450	alkyl hydroperoxide reductase
DBW_RS12290	COG4974	Belongs to the 'phage' integrase family
DBW_RS12295	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DBW_RS12300	COG0432	Pfam Uncharacterised protein family UPF0047
DBW_RS12305	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DBW_RS12315	COG1410	methionine synthase
DBW_RS12315	COG0646	methionine synthase
DBW_RS12320	COG0646	methionine synthase
DBW_RS12320	COG1410	methionine synthase
DBW_RS12325	COG1773	rubredoxin
DBW_RS12335	COG1349	DNA-binding transcription factor activity
DBW_RS12360	COG3437	response regulator, receiver
DBW_RS12360	COG0784	Response regulator, receiver
DBW_RS12375	COG1940	carbohydrate kinase activity
DBW_RS12395	COG0590	tRNA wobble adenosine to inosine editing
DBW_RS12395	COG0037	tRNA processing
DBW_RS12405	COG1335	isochorismatase
DBW_RS12420	COG0116	Belongs to the methyltransferase superfamily
DBW_RS12420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DBW_RS12425	COG0613	PHP domain protein
DBW_RS12435	COG2183	response to ionizing radiation
DBW_RS12440	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DBW_RS12450	COG4191	Histidine kinase
DBW_RS12465	COG2181	nitrate reductase activity
DBW_RS12475	COG1140	nitrate reductase beta subunit
DBW_RS12480	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DBW_RS12490	COG0444	Belongs to the ABC transporter superfamily
DBW_RS12495	COG4608	Belongs to the ABC transporter superfamily
DBW_RS12505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DBW_RS12520	COG5557	Pfam Polysulphide reductase, NrfD
DBW_RS12525	COG0437	4 iron, 4 sulfur cluster binding
DBW_RS12525	COG3064	Membrane
DBW_RS12560	COG4191	Histidine kinase
DBW_RS12570	COG0628	permease
DBW_RS12605	COG1388	LysM domain
DBW_RS12605	COG0791	NLP P60 protein
DBW_RS12615	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DBW_RS12630	COG1971	Probably functions as a manganese efflux pump
DBW_RS12670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DBW_RS12675	COG0772	Belongs to the SEDS family
DBW_RS12680	COG0768	penicillin binding
DBW_RS12695	COG1077	Cell shape determining protein MreB Mrl
DBW_RS12705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DBW_RS12715	COG2252	PERMEase
DBW_RS12725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DBW_RS12735	COG0488	(ABC) transporter
DBW_RS12740	COG2264	protein methyltransferase activity
DBW_RS12755	COG2814	Major facilitator Superfamily
DBW_RS12775	COG1846	Transcriptional regulator
DBW_RS12800	COG0745	RESPONSE REGULATOR receiver
DBW_RS12805	COG2205	protein histidine kinase activity
DBW_RS12810	COG3344	reverse transcriptase
DBW_RS12830	COG0488	(ABC) transporter
DBW_RS12835	COG1530	ribonuclease E activity
DBW_RS12845	COG0525	valine-tRNA ligase activity
DBW_RS12865	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DBW_RS12885	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DBW_RS12890	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DBW_RS12895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DBW_RS12900	COG0653	protein targeting
DBW_RS12905	COG0739	heme binding
DBW_RS12910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DBW_RS12915	COG0497	DNA recombination
DBW_RS12920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DBW_RS12925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DBW_RS12940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DBW_RS12955	COG0584	glycerophosphoryl diester phosphodiesterase
DBW_RS12965	COG1494	fructose-1,6-bisphosphatase
DBW_RS12975	COG0217	transcriptional regulatory protein
DBW_RS12980	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DBW_RS12985	COG0632	four-way junction helicase activity
DBW_RS12990	COG2255	four-way junction helicase activity
DBW_RS13010	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DBW_RS13020	COG1752	Esterase of the alpha-beta hydrolase superfamily
DBW_RS13030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DBW_RS13035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DBW_RS13040	COG5000	phosphorelay sensor kinase activity
DBW_RS13045	COG2204	response regulator
DBW_RS13050	COG3344	reverse transcriptase
DBW_RS13055	COG1484	DNA-dependent DNA replication
DBW_RS13060	COG4584	PFAM Integrase catalytic
DBW_RS13065	COG3328	transposase activity
DBW_RS13120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DBW_RS13125	COG1692	metallophosphoesterase
DBW_RS13130	COG1418	mRNA catabolic process
DBW_RS13135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DBW_RS13140	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DBW_RS13150	COG0552	protein localization to endoplasmic reticulum
DBW_RS13160	COG1196	nuclear chromosome segregation
DBW_RS13165	COG0564	pseudouridine synthase activity
DBW_RS13175	COG2226	methyltransferase
DBW_RS13180	COG0494	nUDIX hydrolase
DBW_RS13200	COG0517	IMP dehydrogenase activity
DBW_RS13200	COG0516	GMP reductase activity
DBW_RS13215	COG0543	2 iron, 2 sulfur cluster binding
DBW_RS13260	COG0189	ligase activity
DBW_RS13280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DBW_RS13285	COG2768	binding domain, Protein
DBW_RS13290	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DBW_RS13300	COG0280	phosphate acetyltransferase
DBW_RS13310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DBW_RS13320	COG0509	glycine decarboxylation via glycine cleavage system
DBW_RS13325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DBW_RS13340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DBW_RS13370	COG0651	ATP synthesis coupled electron transport
DBW_RS13380	COG0651	ATP synthesis coupled electron transport
DBW_RS13395	COG0651	ATP synthesis coupled electron transport
DBW_RS13400	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
DBW_RS13400	COG3261	NADH dehydrogenase
DBW_RS13405	COG3260	NADH ubiquinone oxidoreductase 20
DBW_RS13410	COG4251	negative regulation of phosphorylation
DBW_RS13460	COG3328	transposase activity
DBW_RS13520	COG3550	peptidyl-serine autophosphorylation
DBW_RS13525	COG1921	L-seryl-tRNASec selenium transferase activity
DBW_RS13535	COG0709	Synthesizes selenophosphate from selenide and ATP
DBW_RS13585	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DBW_RS13610	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DBW_RS13620	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DBW_RS13625	COG1181	Belongs to the D-alanine--D-alanine ligase family
DBW_RS13630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DBW_RS13635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DBW_RS13640	COG0772	Belongs to the SEDS family
DBW_RS13645	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DBW_RS13650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DBW_RS13655	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DBW_RS13660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DBW_RS13670	COG3116	cell division
DBW_RS13675	COG0275	rRNA processing
DBW_RS13680	COG2001	Belongs to the MraZ family
DBW_RS13685	COG4536	flavin adenine dinucleotide binding
DBW_RS13690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DBW_RS13695	COG1254	Belongs to the acylphosphatase family
DBW_RS13705	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DBW_RS13715	COG0792	nuclease activity
DBW_RS13720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DBW_RS13725	COG0335	large ribosomal subunit rRNA binding
DBW_RS13730	COG4752	Belongs to the RNA methyltransferase TrmD family
DBW_RS13735	COG0336	Belongs to the RNA methyltransferase TrmD family
DBW_RS13740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DBW_RS13745	COG1837	Belongs to the UPF0109 family
DBW_RS13750	COG0228	four-way junction DNA binding
DBW_RS13755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DBW_RS13770	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DBW_RS13775	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DBW_RS13795	COG1216	Glycosyl transferase, family 2
DBW_RS13800	COG0297	glycogen (starch) synthase activity
DBW_RS13815	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DBW_RS13860	COG0463	Glycosyl transferase, family 2
DBW_RS13895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DBW_RS13900	COG1333	cytochrome c biogenesis protein
DBW_RS13905	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DBW_RS13910	COG0151	Belongs to the GarS family
DBW_RS13915	COG0138	bifunctional purine biosynthesis protein purh
DBW_RS13925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DBW_RS13935	COG0351	phosphomethylpyrimidine kinase
DBW_RS13935	COG0352	thiamine-phosphate diphosphorylase activity
DBW_RS13940	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DBW_RS13950	COG1166	arginine decarboxylase activity
DBW_RS13970	COG1476	TRANSCRIPTIONal
DBW_RS13975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DBW_RS13980	COG0191	fructose-bisphosphate aldolase activity
DBW_RS13990	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DBW_RS14020	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DBW_RS14025	COG0542	response to heat
DBW_RS14030	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DBW_RS14050	COG1322	Protein conserved in bacteria
DBW_RS14060	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DBW_RS14070	COG1323	Belongs to the UPF0348 family
DBW_RS14075	COG1489	DNA binding
DBW_RS14080	COG0560	Phosphoserine phosphatase
DBW_RS14080	COG3830	Belongs to the UPF0237 family
DBW_RS14110	COG4584	PFAM Integrase catalytic
DBW_RS14115	COG1484	DNA-dependent DNA replication
DBW_RS14150	COG1872	DUF167
DBW_RS14165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DBW_RS14180	COG0579	oxidoreductase
DBW_RS14200	COG0023	Translation Initiation Factor
DBW_RS14295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DBW_RS14310	COG1162	GTPase activity
DBW_RS14320	COG5002	protein histidine kinase activity
DBW_RS14330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DBW_RS14350	COG1484	DNA-dependent DNA replication
DBW_RS14355	COG4584	PFAM Integrase catalytic
DBW_RS14370	COG2132	Multicopper oxidase
DBW_RS14395	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DBW_RS14400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DBW_RS14415	COG0493	'glutamate synthase
DBW_RS14420	COG0069	glutamate synthase activity
DBW_RS14420	COG0070	glutamate synthase
DBW_RS14420	COG0067	glutamate synthase
DBW_RS14440	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DBW_RS14485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DBW_RS14495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DBW_RS14535	COG1305	Transglutaminase-like
DBW_RS14540	COG3394	polysaccharide catabolic process
DBW_RS14545	COG0438	transferase activity, transferring glycosyl groups
DBW_RS14550	COG1136	(ABC) transporter
DBW_RS14550	COG0577	efflux transmembrane transporter activity
DBW_RS14555	COG1136	(ABC) transporter
DBW_RS14555	COG0577	efflux transmembrane transporter activity
DBW_RS14560	COG0577	efflux transmembrane transporter activity
DBW_RS14560	COG1136	(ABC) transporter
DBW_RS14565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DBW_RS14570	COG1073	alpha beta
DBW_RS14575	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DBW_RS14580	COG2176	DNA-directed DNA polymerase activity
DBW_RS14580	COG5002	protein histidine kinase activity
DBW_RS14590	COG2223	nitrite transmembrane transporter activity
DBW_RS14595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DBW_RS14600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DBW_RS14605	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DBW_RS14615	COG0514	ATP-dependent DNA helicase (RecQ)
DBW_RS14635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DBW_RS14670	COG0109	protoheme IX farnesyltransferase activity
DBW_RS14675	COG1592	Rubrerythrin
DBW_RS14680	COG2033	superoxide reductase activity
DBW_RS14700	COG0745	RESPONSE REGULATOR receiver
DBW_RS14720	COG0598	Magnesium transport protein CorA
DBW_RS14730	COG3264	Mechanosensitive ion channel
DBW_RS14730	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DBW_RS14735	COG0415	Belongs to the DNA photolyase family
DBW_RS14740	COG0586	Pfam SNARE associated Golgi protein
DBW_RS14745	COG2267	carboxylic ester hydrolase activity
DBW_RS14755	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DBW_RS14770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DBW_RS14780	COG2192	nodulation
DBW_RS14805	COG2204	response regulator
DBW_RS14810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DBW_RS14810	COG4191	Histidine kinase
DBW_RS14860	COG2204	response regulator
DBW_RS14865	COG3852	Histidine kinase
DBW_RS14875	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DBW_RS14880	COG3959	Transketolase, thiamine diphosphate binding domain
DBW_RS14890	COG0646	methionine synthase
DBW_RS14890	COG1410	methionine synthase
DBW_RS14900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DBW_RS14935	COG0864	Transcriptional regulator
DBW_RS14940	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DBW_RS14945	COG1122	ATPase activity
DBW_RS14950	COG3328	transposase activity
DBW_RS14965	COG0411	ABC transporter
DBW_RS14975	COG0559	Belongs to the binding-protein-dependent transport system permease family
DBW_RS14985	COG2050	protein possibly involved in aromatic compounds catabolism
DBW_RS14990	COG2363	Small membrane protein
DBW_RS15000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DBW_RS15005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DBW_RS15015	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DBW_RS15020	COG1492	cobalamin metabolic process
DBW_RS15065	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DBW_RS15070	COG1122	ATPase activity
DBW_RS15075	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DBW_RS15080	COG0310	cobalt ion transport
DBW_RS15085	COG0310	cobalt ion transport
DBW_RS15100	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DBW_RS15105	COG1797	cobyrinic acid a,c-diamide synthase activity
DBW_RS15115	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DBW_RS15120	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DBW_RS15130	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DBW_RS15135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DBW_RS15155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DBW_RS15175	COG3706	GGDEF domain
DBW_RS15180	COG1028	Short-chain dehydrogenase reductase Sdr
DBW_RS15210	COG0488	(ABC) transporter
DBW_RS15230	COG0697	spore germination
DBW_RS15290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DBW_RS15295	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DBW_RS15320	COG2814	Major facilitator Superfamily
DBW_RS15345	COG1492	cobalamin metabolic process
DBW_RS15350	COG1272	protein, Hemolysin III
DBW_RS15365	COG1959	2 iron, 2 sulfur cluster binding
DBW_RS15370	COG1606	tRNA processing
DBW_RS15385	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DBW_RS15400	COG0668	transmembrane transport
DBW_RS15415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DBW_RS15495	COG0513	Belongs to the DEAD box helicase family
DBW_RS15525	COG0494	nUDIX hydrolase
DBW_RS15530	COG1597	lipid kinase activity
DBW_RS15535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DBW_RS15545	COG0463	Glycosyl transferase, family 2
DBW_RS15555	COG0826	peptidase U32
DBW_RS15570	COG0758	DNA mediated transformation
DBW_RS15580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DBW_RS15585	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DBW_RS15590	COG0424	maF-like protein
DBW_RS15595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DBW_RS15600	COG0546	phosphoglycolate phosphatase activity
DBW_RS15615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DBW_RS15645	COG1242	4 iron, 4 sulfur cluster binding
DBW_RS15650	COG5002	protein histidine kinase activity
DBW_RS15655	COG0745	RESPONSE REGULATOR receiver
DBW_RS15660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DBW_RS15670	COG0297	glycogen (starch) synthase activity
DBW_RS15685	COG0569	domain protein
DBW_RS15690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DBW_RS15710	COG1496	oxidoreductase activity
DBW_RS15715	COG0564	pseudouridine synthase activity
DBW_RS15730	COG1396	sequence-specific DNA binding
DBW_RS15735	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DBW_RS15750	COG1773	rubredoxin
DBW_RS15760	COG0321	lipoyl(octanoyl) transferase activity
DBW_RS15765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DBW_RS15790	COG1376	ErfK ybiS ycfS ynhG family protein
DBW_RS15790	COG1388	LysM domain
DBW_RS15805	COG0508	dehydrogenase complex catalyzes the overall conversion of
DBW_RS15845	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DBW_RS15860	COG0358	DNA primase activity
DBW_RS15865	COG1193	negative regulation of DNA recombination
DBW_RS15880	COG0140	phosphoribosyl-ATP diphosphatase activity
DBW_RS15885	COG0107	imidazoleglycerol-phosphate synthase activity
DBW_RS15890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DBW_RS15895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DBW_RS15900	COG0131	Imidazoleglycerol-phosphate dehydratase
DBW_RS15905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DBW_RS15910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DBW_RS15915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DBW_RS15920	COG2890	protein-(glutamine-N5) methyltransferase activity
DBW_RS15925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DBW_RS15930	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DBW_RS15935	COG0254	rRNA binding
DBW_RS15940	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DBW_RS15950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DBW_RS15960	COG1959	2 iron, 2 sulfur cluster binding
DBW_RS15965	COG0004	ammonium transporteR
DBW_RS15970	COG0175	sulfate reduction
DBW_RS15975	COG0175	sulfate reduction
DBW_RS15985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DBW_RS15990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DBW_RS15995	COG0626	cystathionine gamma-synthase activity
DBW_RS16000	COG0626	cystathionine gamma-synthase activity
DBW_RS16005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DBW_RS16025	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DBW_RS16035	COG4251	negative regulation of phosphorylation
DBW_RS16040	COG0784	Response regulator, receiver
DBW_RS16075	COG1368	sulfuric ester hydrolase activity
DBW_RS16115	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DBW_RS16140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DBW_RS16150	COG0281	malic enzyme
DBW_RS16170	COG1408	metallophosphoesterase
DBW_RS16195	COG3328	transposase activity
DBW_RS16215	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DBW_RS16245	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DBW_RS16250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DBW_RS16285	COG5557	Pfam Polysulphide reductase, NrfD
DBW_RS16290	COG3064	Membrane
DBW_RS16290	COG0437	4 iron, 4 sulfur cluster binding
DBW_RS16310	COG2204	response regulator
DBW_RS16315	COG0375	protein maturation
DBW_RS16320	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DBW_RS16325	COG0298	carbon dioxide binding
DBW_RS16335	COG0309	Hydrogenase expression formation protein (HypE)
DBW_RS16365	COG0116	Belongs to the methyltransferase superfamily
DBW_RS16365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DBW_RS16375	COG0604	alcohol dehydrogenase
DBW_RS16385	COG4191	Histidine kinase
DBW_RS16390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DBW_RS16405	COG0315	cyclic pyranopterin monophosphate synthase activity
DBW_RS16410	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DBW_RS16425	COG3875	lactate racemase activity
DBW_RS16430	COG0277	FAD linked oxidase domain protein
DBW_RS16440	COG2340	Cysteine-rich secretory protein family
DBW_RS16445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DBW_RS16455	COG0482	sulfurtransferase activity
DBW_RS16465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DBW_RS16470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DBW_RS16495	COG0688	phosphatidylethanolamine metabolic process
DBW_RS16510	COG1785	Belongs to the alkaline phosphatase family
DBW_RS16525	COG2062	phosphohistidine phosphatase, SixA
DBW_RS16530	COG2326	polyphosphate kinase activity
DBW_RS16545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DBW_RS16555	COG0248	Ppx GppA phosphatase
DBW_RS16580	COG2188	Transcriptional regulator
DBW_RS16585	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DBW_RS16595	COG3639	organic phosphonate transmembrane transporter activity
DBW_RS16620	COG3627	carbon phosphorus lyase activity
DBW_RS16625	COG4107	phosphonate C-P lyase system protein PhnK
DBW_RS16630	COG4778	phosphonate C-P lyase system protein PhnL
DBW_RS16655	COG0671	phosphoesterase, PA-phosphatase related
DBW_RS16665	COG0745	RESPONSE REGULATOR receiver
DBW_RS16680	COG1960	acyl-CoA dehydrogenase activity
DBW_RS16690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DBW_RS16695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DBW_RS16700	COG1309	transcriptional regulator
DBW_RS16705	COG0475	glutathione-regulated potassium exporter activity
DBW_RS16705	COG0569	domain protein
DBW_RS16710	COG0569	domain protein
DBW_RS16720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DBW_RS16725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DBW_RS16750	COG0330	HflC and HflK could
DBW_RS16755	COG0612	Peptidase, M16
DBW_RS16765	COG0113	porphobilinogen synthase activity
DBW_RS16820	COG3328	transposase activity
DBW_RS16835	COG3420	alginic acid biosynthetic process
DBW_RS16865	COG2823	Periplasmic or secreted lipoprotein
DBW_RS16870	COG2205	protein histidine kinase activity
DBW_RS16890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DBW_RS16910	COG0356	it plays a direct role in the translocation of protons across the membrane
DBW_RS16920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DBW_RS16925	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DBW_RS16930	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DBW_RS16935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DBW_RS16940	COG3437	response regulator, receiver
DBW_RS16940	COG0784	Response regulator, receiver
DBW_RS16960	COG0181	hydroxymethylbilane synthase activity
DBW_RS16970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DBW_RS16980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DBW_RS16985	COG3118	belongs to the thioredoxin family
DBW_RS16995	COG1490	D-aminoacyl-tRNA deacylase activity
DBW_RS17000	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DBW_RS17025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DBW_RS17040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DBW_RS17045	COG2264	protein methyltransferase activity
DBW_RS17050	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DBW_RS17060	COG5002	protein histidine kinase activity
DBW_RS17070	COG2197	response regulator
DBW_RS17075	COG2188	Transcriptional regulator
DBW_RS17080	COG0310	cobalt ion transport
DBW_RS17085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DBW_RS17095	COG0247	lactate metabolic process
DBW_RS17100	COG0277	FAD linked oxidase domain protein
DBW_RS17120	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DBW_RS17125	COG1028	Short-chain dehydrogenase reductase Sdr
DBW_RS17150	COG0840	transmembrane signaling receptor activity
DBW_RS17160	COG3108	Peptidase M15
DBW_RS17180	COG2003	Belongs to the UPF0758 family
DBW_RS17185	COG0826	peptidase U32
DBW_RS17200	COG1047	Peptidyl-prolyl cis-trans
DBW_RS17235	COG1741	Belongs to the pirin family
DBW_RS17245	COG4399	Belongs to the UPF0754 family
DBW_RS17260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DBW_RS17265	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DBW_RS17275	COG1132	(ABC) transporter
DBW_RS17280	COG1132	(ABC) transporter
DBW_RS17300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DBW_RS17305	COG1666	GTP binding
DBW_RS17315	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DBW_RS17320	COG1776	CheC inhibitor of MCP methylation
DBW_RS17325	COG0643	Histidine kinase
DBW_RS17325	COG2198	Histidine kinase
DBW_RS17330	COG2201	protein-glutamate methylesterase activity
DBW_RS17335	COG0835	chemotaxis
DBW_RS17340	COG0840	transmembrane signaling receptor activity
DBW_RS17345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DBW_RS17350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DBW_RS17355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DBW_RS17365	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DBW_RS17370	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DBW_RS17380	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DBW_RS17385	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
DBW_RS17435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DBW_RS17440	COG1199	ATP-dependent helicase activity
DBW_RS17450	COG0793	Belongs to the peptidase S41A family
DBW_RS17455	COG2181	nitrate reductase activity
DBW_RS17455	COG0247	lactate metabolic process
DBW_RS17460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DBW_RS17475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DBW_RS17495	COG0436	Aminotransferase
DBW_RS17500	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DBW_RS17510	COG1333	cytochrome c biogenesis protein
DBW_RS17515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DBW_RS17525	COG0348	domain, Protein
DBW_RS17540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DBW_RS17545	COG0346	lactoylglutathione lyase activity
DBW_RS17550	COG1703	isobutyryl-CoA mutase activity
DBW_RS17555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DBW_RS17555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DBW_RS17560	COG1396	sequence-specific DNA binding
DBW_RS17570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DBW_RS17575	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DBW_RS17585	COG0439	Biotin carboxylase
DBW_RS17590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DBW_RS17595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DBW_RS17605	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DBW_RS17625	COG0730	response to heat
DBW_RS17630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DBW_RS17675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DBW_RS17685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DBW_RS17690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DBW_RS17715	COG1592	Rubrerythrin
DBW_RS17730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DBW_RS17735	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DBW_RS17740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DBW_RS17745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DBW_RS17755	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DBW_RS17760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DBW_RS17765	COG0805	protein transport
DBW_RS17770	COG3706	GGDEF domain
DBW_RS17775	COG2096	Adenosyltransferase
DBW_RS17780	COG1131	(ABC) transporter
DBW_RS17785	COG0842	Transport permease protein
DBW_RS17800	COG2186	Transcriptional regulator
DBW_RS17815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DBW_RS17820	COG2186	Transcriptional regulator
DBW_RS17825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DBW_RS17830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DBW_RS17835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DBW_RS17840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DBW_RS17845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DBW_RS17850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DBW_RS17865	COG1475	DNA binding
DBW_RS17870	COG1192	Involved in chromosome partitioning
DBW_RS17875	COG0357	Ribosomal RNA small subunit methyltransferase G
DBW_RS17880	COG0445	tRNA wobble uridine modification
DBW_RS17885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DBW_RS17890	COG0706	membrane insertase activity
DBW_RS17900	COG0230	Belongs to the bacterial ribosomal protein bL34 family