locus-tag	class	description
APS40_RS00030	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APS40_RS00035	COG0395	ABC-type sugar transport system, permease component
APS40_RS00040	COG3458	cephalosporin-C deacetylase activity
APS40_RS00045	COG1609	Transcriptional regulator
APS40_RS00050	COG3250	beta-galactosidase activity
APS40_RS00060	COG1175	transmembrane transport
APS40_RS00065	COG0395	ABC-type sugar transport system, permease component
APS40_RS00070	COG0477	Major facilitator Superfamily
APS40_RS00090	COG2814	Major facilitator Superfamily
APS40_RS00100	COG1132	(ABC) transporter
APS40_RS00110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APS40_RS00135	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APS40_RS00150	COG0440	acetolactate synthase activity
APS40_RS00155	COG0028	Belongs to the TPP enzyme family
APS40_RS00175	COG0488	(ABC) transporter
APS40_RS00190	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS00210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APS40_RS00215	COG1360	Flagellar Motor Protein
APS40_RS00220	COG1278	Cold shock
APS40_RS00240	COG0534	Mate efflux family protein
APS40_RS00245	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APS40_RS00250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APS40_RS00255	COG0560	Phosphoserine phosphatase
APS40_RS00255	COG3830	Belongs to the UPF0237 family
APS40_RS00260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APS40_RS00265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APS40_RS00275	COG0330	HflC and HflK could
APS40_RS00280	COG0330	HflC and HflK could
APS40_RS00305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APS40_RS00335	COG0697	spore germination
APS40_RS00350	COG2264	protein methyltransferase activity
APS40_RS00375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APS40_RS00385	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APS40_RS00395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APS40_RS00400	COG0849	cell division
APS40_RS00405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APS40_RS00410	COG1181	Belongs to the D-alanine--D-alanine ligase family
APS40_RS00415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APS40_RS00420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APS40_RS00425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APS40_RS00435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APS40_RS00440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APS40_RS00445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APS40_RS00465	COG0604	alcohol dehydrogenase
APS40_RS00470	COG1476	TRANSCRIPTIONal
APS40_RS00480	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APS40_RS00495	COG0640	Transcriptional regulator
APS40_RS00505	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
APS40_RS00510	COG0583	DNA-binding transcription factor activity
APS40_RS00525	COG2962	Rard protein
APS40_RS00540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APS40_RS00560	COG4106	trans-aconitate 2-methyltransferase activity
APS40_RS00565	COG0137	argininosuccinate synthase activity
APS40_RS00570	COG0488	(ABC) transporter
APS40_RS00575	COG3273	potassium ion transport
APS40_RS00575	COG0471	metal ion transport
APS40_RS00590	COG2515	1-aminocyclopropane-1-carboxylate deaminase
APS40_RS00605	COG0243	molybdopterin cofactor binding
APS40_RS00625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APS40_RS00645	COG0559	Belongs to the binding-protein-dependent transport system permease family
APS40_RS00665	COG0829	nickel cation binding
APS40_RS00670	COG0831	urea catabolic process
APS40_RS00675	COG0832	Belongs to the urease beta subunit family
APS40_RS00700	COG0804	urea catabolic process
APS40_RS00715	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
APS40_RS00720	COG0830	nickel cation binding
APS40_RS00730	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APS40_RS00735	COG0456	acetyltransferase
APS40_RS00745	COG0033	Phosphoglucomutase
APS40_RS00755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APS40_RS00760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APS40_RS00765	COG0058	SHG alpha-glucan phosphorylase activity
APS40_RS00770	COG0475	glutathione-regulated potassium exporter activity
APS40_RS00770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APS40_RS00775	COG0628	permease
APS40_RS00780	COG1957	nucleoside hydrolase
APS40_RS00800	COG1280	lysine exporter protein (LysE YggA)
APS40_RS00805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APS40_RS00815	COG2094	Belongs to the DNA glycosylase MPG family
APS40_RS00855	COG2968	Membrane
APS40_RS00870	COG2261	transglycosylase associated protein
APS40_RS00880	COG0730	response to heat
APS40_RS00940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APS40_RS00950	COG1295	ribonuclease BN
APS40_RS00965	COG2814	Major facilitator Superfamily
APS40_RS00985	COG0505	Belongs to the CarA family
APS40_RS01000	COG3706	GGDEF domain
APS40_RS01010	COG2321	neutral zinc metallopeptidase
APS40_RS01015	COG0737	Belongs to the 5'-nucleotidase family
APS40_RS01020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APS40_RS01040	COG2814	Major facilitator Superfamily
APS40_RS01050	COG2814	Major facilitator Superfamily
APS40_RS01095	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APS40_RS01145	COG0110	maltose O-acetyltransferase activity
APS40_RS01165	COG2226	methyltransferase
APS40_RS01170	COG1278	Cold shock
APS40_RS01180	COG1309	transcriptional regulator
APS40_RS01185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APS40_RS01190	COG0492	ferredoxin-NADP+ reductase activity
APS40_RS01195	COG0583	DNA-binding transcription factor activity
APS40_RS01210	COG0598	Magnesium transport protein CorA
APS40_RS01215	COG0656	L-ascorbic acid biosynthetic process
APS40_RS01225	COG2852	Protein conserved in bacteria
APS40_RS01235	COG0436	Aminotransferase
APS40_RS01255	COG0517	IMP dehydrogenase activity
APS40_RS01255	COG0516	GMP reductase activity
APS40_RS01260	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APS40_RS01270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APS40_RS01275	COG0305	Participates in initiation and elongation during chromosome replication
APS40_RS01295	COG1435	thymidine kinase activity
APS40_RS01300	COG1607	acyl-coa hydrolase
APS40_RS01340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APS40_RS01360	COG2814	Major facilitator Superfamily
APS40_RS01365	COG0556	nucleotide-excision repair
APS40_RS01470	COG0477	Major facilitator Superfamily
APS40_RS01480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APS40_RS01490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APS40_RS01515	COG0583	DNA-binding transcription factor activity
APS40_RS01520	COG2814	Major facilitator Superfamily
APS40_RS01525	COG0667	Aldo Keto reductase
APS40_RS01530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APS40_RS01535	COG1846	Transcriptional regulator
APS40_RS01540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APS40_RS01570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APS40_RS01580	COG1496	oxidoreductase activity
APS40_RS01585	COG3415	Transposase
APS40_RS01585	COG2801	Transposase and inactivated derivatives
APS40_RS01595	COG3795	YCII-related domain
APS40_RS01600	COG0346	lactoylglutathione lyase activity
APS40_RS01610	COG3795	YCII-related domain
APS40_RS01615	COG4941	Belongs to the sigma-70 factor family
APS40_RS01620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APS40_RS01625	COG0193	aminoacyl-tRNA hydrolase activity
APS40_RS01630	COG2826	transposase and inactivated derivatives, IS30 family
APS40_RS01635	COG0012	GTP binding
APS40_RS01650	COG2030	dehydratase
APS40_RS01660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APS40_RS01670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APS40_RS01670	COG2857	Cytochrome c1
APS40_RS01675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APS40_RS01675	COG2857	Cytochrome c1
APS40_RS01680	COG0723	plastoquinol--plastocyanin reductase activity
APS40_RS01685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APS40_RS01690	COG0408	coproporphyrinogen oxidase activity
APS40_RS01740	COG0494	nUDIX hydrolase
APS40_RS01750	COG1365	unkown
APS40_RS01755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APS40_RS01765	COG0604	alcohol dehydrogenase
APS40_RS01795	COG0789	Transcriptional regulator
APS40_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS01810	COG1063	alcohol dehydrogenase
APS40_RS01835	COG5001	Diguanylate cyclase
APS40_RS01840	COG2852	Protein conserved in bacteria
APS40_RS01850	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
APS40_RS01860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APS40_RS01865	COG0402	S-adenosylhomocysteine deaminase activity
APS40_RS01880	COG1079	Belongs to the binding-protein-dependent transport system permease family
APS40_RS01885	COG4603	Belongs to the binding-protein-dependent transport system permease family
APS40_RS01890	COG3845	ABC transporter
APS40_RS01910	COG2351	hydroxyisourate hydrolase activity
APS40_RS01920	COG0640	Transcriptional regulator
APS40_RS01975	COG3257	ureidoglycine aminohydrolase activity
APS40_RS01990	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
APS40_RS02010	COG0513	Belongs to the DEAD box helicase family
APS40_RS02025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APS40_RS02055	COG0737	Belongs to the 5'-nucleotidase family
APS40_RS02070	COG0673	inositol 2-dehydrogenase activity
APS40_RS02075	COG0673	inositol 2-dehydrogenase activity
APS40_RS02100	COG1653	transport
APS40_RS02105	COG1609	Transcriptional regulator
APS40_RS02155	COG2897	thiosulfate sulfurtransferase activity
APS40_RS02170	COG4214	carbohydrate transport
APS40_RS02175	COG1129	ABC transporter
APS40_RS02180	COG4213	ABC transporter substrate-binding protein
APS40_RS02185	COG2186	Transcriptional regulator
APS40_RS02190	COG1012	belongs to the aldehyde dehydrogenase family
APS40_RS02195	COG1177	transmembrane transport
APS40_RS02200	COG1176	ABC-type spermidine putrescine transport system, permease component I
APS40_RS02205	COG3842	ATPase activity
APS40_RS02210	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APS40_RS02215	COG0583	DNA-binding transcription factor activity
APS40_RS02240	COG2307	Protein conserved in bacteria
APS40_RS02240	COG2308	Evidence 4 Homologs of previously reported genes of
APS40_RS02245	COG1305	Transglutaminase-like
APS40_RS02270	COG3920	Histidine kinase
APS40_RS02295	COG0784	Response regulator, receiver
APS40_RS02325	COG4160	amino acid transport
APS40_RS02340	COG1312	Catalyzes the dehydration of D-mannonate
APS40_RS02345	COG1802	Transcriptional regulator
APS40_RS02350	COG1454	alcohol dehydrogenase
APS40_RS02360	COG2860	membrane
APS40_RS02375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS40_RS02390	COG0673	inositol 2-dehydrogenase activity
APS40_RS02395	COG1309	transcriptional regulator
APS40_RS02400	COG1653	transport
APS40_RS02405	COG1175	transmembrane transport
APS40_RS02410	COG0395	ABC-type sugar transport system, permease component
APS40_RS02425	COG0673	inositol 2-dehydrogenase activity
APS40_RS02430	COG3842	ATPase activity
APS40_RS02435	COG0506	proline dehydrogenase activity
APS40_RS02435	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APS40_RS02435	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APS40_RS02445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APS40_RS02455	COG4254	PFAM FecR protein
APS40_RS02465	COG1132	(ABC) transporter
APS40_RS02470	COG1132	(ABC) transporter
APS40_RS02515	COG0395	ABC-type sugar transport system, permease component
APS40_RS02520	COG1175	transmembrane transport
APS40_RS02530	COG1802	Transcriptional regulator
APS40_RS02535	COG5441	Belongs to the UPF0261 family
APS40_RS02540	COG5564	TIM-barrel signal transduction protein
APS40_RS02545	COG2971	BadF BadG BcrA BcrD
APS40_RS02565	COG1116	anion transmembrane transporter activity
APS40_RS02570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APS40_RS02600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APS40_RS02615	COG4176	ABC-type proline glycine betaine transport system permease component
APS40_RS02620	COG0517	IMP dehydrogenase activity
APS40_RS02620	COG4175	Glycine betaine
APS40_RS02625	COG0589	response to stress
APS40_RS02635	COG2813	Specifically methylates the guanine in position
APS40_RS02685	COG0306	phosphate transporter
APS40_RS02690	COG1392	Phosphate transport regulator
APS40_RS02700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APS40_RS02715	COG0656	L-ascorbic acid biosynthetic process
APS40_RS02755	COG0071	Belongs to the small heat shock protein (HSP20) family
APS40_RS02795	COG1278	Cold shock
APS40_RS02810	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APS40_RS02850	COG3920	Histidine kinase
APS40_RS02855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APS40_RS02860	COG3685	Protein conserved in bacteria
APS40_RS02870	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APS40_RS02880	COG0438	transferase activity, transferring glycosyl groups
APS40_RS02895	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APS40_RS02915	COG0438	transferase activity, transferring glycosyl groups
APS40_RS03045	COG0459	protein refolding
APS40_RS03050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APS40_RS03055	COG5425	PFAM Usg family protein
APS40_RS03060	COG0071	Belongs to the small heat shock protein (HSP20) family
APS40_RS03085	COG0402	S-adenosylhomocysteine deaminase activity
APS40_RS03090	COG0402	S-adenosylhomocysteine deaminase activity
APS40_RS03105	COG0395	ABC-type sugar transport system, permease component
APS40_RS03110	COG1175	transmembrane transport
APS40_RS03120	COG3842	ATPase activity
APS40_RS03135	COG4608	Belongs to the ABC transporter superfamily
APS40_RS03145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS03150	COG0601	transmembrane transport
APS40_RS03155	COG0747	negative chemotaxis
APS40_RS03170	COG0477	Major facilitator Superfamily
APS40_RS03190	COG0642	Histidine kinase
APS40_RS03215	COG0395	ABC-type sugar transport system, permease component
APS40_RS03225	COG1129	ABC transporter
APS40_RS03240	COG0673	inositol 2-dehydrogenase activity
APS40_RS03245	COG1609	Transcriptional regulator
APS40_RS03250	COG0395	ABC-type sugar transport system, permease component
APS40_RS03255	COG1175	transmembrane transport
APS40_RS03275	COG1609	Transcriptional regulator
APS40_RS03280	COG4608	Belongs to the ABC transporter superfamily
APS40_RS03285	COG0444	Belongs to the ABC transporter superfamily
APS40_RS03290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS03305	COG3507	Belongs to the glycosyl hydrolase 43 family
APS40_RS03310	COG3920	Histidine kinase
APS40_RS03315	COG2183	response to ionizing radiation
APS40_RS03345	COG0601	transmembrane transport
APS40_RS03350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS03360	COG0444	Belongs to the ABC transporter superfamily
APS40_RS03365	COG4608	Belongs to the ABC transporter superfamily
APS40_RS03370	COG1228	amidohydrolase
APS40_RS03375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APS40_RS03385	COG0438	transferase activity, transferring glycosyl groups
APS40_RS03390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS40_RS03410	COG0463	Glycosyl transferase, family 2
APS40_RS03445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APS40_RS03450	COG4993	Dehydrogenase
APS40_RS03455	COG2863	cytochrome
APS40_RS03470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APS40_RS03475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APS40_RS03475	COG2010	Cytochrome c
APS40_RS03480	COG3038	cytochrome b561
APS40_RS03485	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS03525	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS03530	COG2971	BadF BadG BcrA BcrD
APS40_RS03540	COG0395	ABC-type sugar transport system, permease component
APS40_RS03545	COG1175	transmembrane transport
APS40_RS03560	COG1940	carbohydrate kinase activity
APS40_RS03565	COG1132	(ABC) transporter
APS40_RS03580	COG0642	Histidine kinase
APS40_RS03585	COG0745	RESPONSE REGULATOR receiver
APS40_RS03595	COG1253	flavin adenine dinucleotide binding
APS40_RS03605	COG3795	YCII-related domain
APS40_RS03615	COG0697	spore germination
APS40_RS03620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APS40_RS03670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APS40_RS03690	COG0250	Participates in transcription elongation, termination and antitermination
APS40_RS03695	COG0640	Transcriptional regulator
APS40_RS03725	COG0583	DNA-binding transcription factor activity
APS40_RS03760	COG0395	ABC-type sugar transport system, permease component
APS40_RS03765	COG1175	transmembrane transport
APS40_RS03770	COG1653	transport
APS40_RS03775	COG1940	carbohydrate kinase activity
APS40_RS03785	COG3842	ATPase activity
APS40_RS03825	COG1278	Cold shock
APS40_RS03840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APS40_RS03885	COG1278	Cold shock
APS40_RS03915	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS03920	COG1129	ABC transporter
APS40_RS03935	COG1228	amidohydrolase
APS40_RS03940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APS40_RS03945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APS40_RS03955	COG0300	oxidoreductase activity
APS40_RS03970	COG2207	Transcriptional regulator
APS40_RS03975	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
APS40_RS03990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APS40_RS03995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS40_RS04000	COG0840	transmembrane signaling receptor activity
APS40_RS04200	COG0745	RESPONSE REGULATOR receiver
APS40_RS04205	COG2205	protein histidine kinase activity
APS40_RS04220	COG1136	(ABC) transporter
APS40_RS04220	COG0577	efflux transmembrane transporter activity
APS40_RS04235	COG0765	amino acid transport
APS40_RS04245	COG1473	amidohydrolase
APS40_RS04265	COG0395	ABC-type sugar transport system, permease component
APS40_RS04270	COG1175	transmembrane transport
APS40_RS04285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS40_RS04290	COG1486	melibiose metabolic process
APS40_RS04295	COG2188	Transcriptional regulator
APS40_RS04305	COG0395	ABC-type sugar transport system, permease component
APS40_RS04310	COG1175	transmembrane transport
APS40_RS04325	COG1609	Transcriptional regulator
APS40_RS04330	COG0667	Aldo Keto reductase
APS40_RS04335	COG1940	carbohydrate kinase activity
APS40_RS04340	COG2084	Dehydrogenase
APS40_RS04350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS04355	COG0601	transmembrane transport
APS40_RS04365	COG0747	negative chemotaxis
APS40_RS04370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APS40_RS04385	COG2197	response regulator
APS40_RS04395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APS40_RS04415	COG0444	Belongs to the ABC transporter superfamily
APS40_RS04420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS04425	COG0601	transmembrane transport
APS40_RS04455	COG0601	transmembrane transport
APS40_RS04460	COG0747	negative chemotaxis
APS40_RS04485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS40_RS04490	COG4172	Belongs to the ABC transporter superfamily
APS40_RS04495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS04500	COG0601	transmembrane transport
APS40_RS04505	COG0747	negative chemotaxis
APS40_RS04510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APS40_RS04515	COG1312	Catalyzes the dehydration of D-mannonate
APS40_RS04520	COG2186	Transcriptional regulator
APS40_RS04540	COG1802	Transcriptional regulator
APS40_RS04550	COG1335	isochorismatase
APS40_RS04560	COG3845	ABC transporter
APS40_RS04570	COG1079	Belongs to the binding-protein-dependent transport system permease family
APS40_RS04600	COG2852	Protein conserved in bacteria
APS40_RS04610	COG1609	Transcriptional regulator
APS40_RS04615	COG1744	ABC transporter substrate-binding protein PnrA-like
APS40_RS04620	COG3845	ABC transporter
APS40_RS04625	COG4603	Belongs to the binding-protein-dependent transport system permease family
APS40_RS04630	COG1079	Belongs to the binding-protein-dependent transport system permease family
APS40_RS04665	COG0179	Fumarylacetoacetate (FAA) hydrolase
APS40_RS04670	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
APS40_RS04680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APS40_RS04685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APS40_RS04690	COG1012	belongs to the aldehyde dehydrogenase family
APS40_RS04710	COG0673	inositol 2-dehydrogenase activity
APS40_RS04750	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS04765	COG2186	Transcriptional regulator
APS40_RS04770	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APS40_RS04775	COG0746	molybdenum cofactor guanylyltransferase activity
APS40_RS04780	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APS40_RS04785	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
APS40_RS04790	COG2080	2 iron, 2 sulfur cluster binding
APS40_RS04805	COG2222	sugar isomerase
APS40_RS04810	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
APS40_RS04820	COG3608	succinylglutamate desuccinylase aspartoacylase
APS40_RS04825	COG1414	Transcriptional regulator
APS40_RS04830	COG3254	rhamnose metabolic process
APS40_RS04835	COG0395	ABC-type sugar transport system, permease component
APS40_RS04840	COG1175	transmembrane transport
APS40_RS04845	COG1653	transport
APS40_RS04865	COG1609	Transcriptional regulator
APS40_RS04870	COG0129	dihydroxy-acid dehydratase activity
APS40_RS04875	COG0473	3-isopropylmalate dehydrogenase activity
APS40_RS04875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APS40_RS04920	COG3254	rhamnose metabolic process
APS40_RS04925	COG3618	amidohydrolase
APS40_RS04930	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS04935	COG0747	negative chemotaxis
APS40_RS04940	COG0601	transmembrane transport
APS40_RS04950	COG0444	Belongs to the ABC transporter superfamily
APS40_RS04955	COG4608	Belongs to the ABC transporter superfamily
APS40_RS04980	COG0395	ABC-type sugar transport system, permease component
APS40_RS04985	COG1175	transmembrane transport
APS40_RS04995	COG1609	Transcriptional regulator
APS40_RS05005	COG1175	transmembrane transport
APS40_RS05010	COG0395	ABC-type sugar transport system, permease component
APS40_RS05020	COG2951	lytic endotransglycosylase activity
APS40_RS05025	COG1609	Transcriptional regulator
APS40_RS05030	COG3250	beta-galactosidase activity
APS40_RS05040	COG4166	transmembrane transport
APS40_RS05045	COG0601	transmembrane transport
APS40_RS05055	COG0444	Belongs to the ABC transporter superfamily
APS40_RS05065	COG1312	Catalyzes the dehydration of D-mannonate
APS40_RS05080	COG4953	penicillin-binding protein 1C
APS40_RS05085	COG2373	Large extracellular alpha-helical protein
APS40_RS05090	COG0243	molybdopterin cofactor binding
APS40_RS05095	COG2146	nitrite reductase [NAD(P)H] activity
APS40_RS05100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APS40_RS05105	COG1116	anion transmembrane transporter activity
APS40_RS05110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APS40_RS05115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APS40_RS05120	COG1116	anion transmembrane transporter activity
APS40_RS05120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APS40_RS05125	COG0745	RESPONSE REGULATOR receiver
APS40_RS05145	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS05150	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS05165	COG0456	acetyltransferase
APS40_RS05170	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APS40_RS05175	COG0395	ABC-type sugar transport system, permease component
APS40_RS05180	COG1175	transmembrane transport
APS40_RS05190	COG2188	Transcriptional regulator
APS40_RS05195	COG4821	SIS domain
APS40_RS05210	COG2816	NAD+ diphosphatase activity
APS40_RS05235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APS40_RS05240	COG1120	ATPase activity
APS40_RS05250	COG0625	glutathione transferase activity
APS40_RS05260	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
APS40_RS05265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APS40_RS05285	COG0346	lactoylglutathione lyase activity
APS40_RS05290	COG2304	oxidoreductase activity
APS40_RS05305	COG0482	sulfurtransferase activity
APS40_RS05325	COG0625	glutathione transferase activity
APS40_RS05330	COG1766	The M ring may be actively involved in energy transduction
APS40_RS05335	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APS40_RS05345	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APS40_RS05350	COG2204	response regulator
APS40_RS05355	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APS40_RS05365	COG2153	protein acetylation
APS40_RS05390	COG0745	RESPONSE REGULATOR receiver
APS40_RS05405	COG0745	RESPONSE REGULATOR receiver
APS40_RS05435	COG0564	pseudouridine synthase activity
APS40_RS05460	COG1178	ABC-type Fe3 transport system permease component
APS40_RS05465	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
APS40_RS05470	COG2826	transposase and inactivated derivatives, IS30 family
APS40_RS05475	COG0110	maltose O-acetyltransferase activity
APS40_RS05520	COG0596	Alpha beta hydrolase
APS40_RS05525	COG2826	transposase and inactivated derivatives, IS30 family
APS40_RS05530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APS40_RS05535	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APS40_RS05610	COG1879	ABC-type sugar transport system periplasmic component
APS40_RS05615	COG4214	carbohydrate transport
APS40_RS05625	COG1609	Transcriptional regulator
APS40_RS05635	COG1175	transmembrane transport
APS40_RS05640	COG0395	ABC-type sugar transport system, permease component
APS40_RS05655	COG3842	ATPase activity
APS40_RS05660	COG0395	ABC-type sugar transport system, permease component
APS40_RS05665	COG1175	transmembrane transport
APS40_RS05675	COG1609	Transcriptional regulator
APS40_RS05690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APS40_RS05690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APS40_RS05700	COG1802	Transcriptional regulator
APS40_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS05725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APS40_RS05735	COG4957	zinc ion binding
APS40_RS05760	COG5425	PFAM Usg family protein
APS40_RS05795	COG0210	DNA helicase
APS40_RS05820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APS40_RS05825	COG2226	methyltransferase
APS40_RS05835	COG0037	tRNA processing
APS40_RS05845	COG2885	chlorophyll binding
APS40_RS05850	COG0823	Involved in the tonB-independent uptake of proteins
APS40_RS05860	COG0848	biopolymer transport protein
APS40_RS05875	COG0824	Thioesterase
APS40_RS05885	COG2255	four-way junction helicase activity
APS40_RS05900	COG0632	four-way junction helicase activity
APS40_RS05905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APS40_RS05910	COG3706	GGDEF domain
APS40_RS05915	COG3706	GGDEF domain
APS40_RS05920	COG0217	transcriptional regulatory protein
APS40_RS05925	COG1692	metallophosphoesterase
APS40_RS05950	COG3609	addiction module antidote protein, CC2985 family
APS40_RS05955	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
APS40_RS05990	COG0126	phosphoglycerate kinase activity
APS40_RS06000	COG3588	fructose-bisphosphate aldolase
APS40_RS06015	COG0483	inositol monophosphate 1-phosphatase activity
APS40_RS06030	COG1132	(ABC) transporter
APS40_RS06035	COG0254	rRNA binding
APS40_RS06085	COG1309	transcriptional regulator
APS40_RS06095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APS40_RS06100	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APS40_RS06170	COG2204	response regulator
APS40_RS06205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS06215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APS40_RS06235	COG3300	MHYT domain
APS40_RS06235	COG5001	Diguanylate cyclase
APS40_RS06240	COG3750	Belongs to the UPF0335 family
APS40_RS06250	COG0469	pyruvate kinase activity
APS40_RS06260	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APS40_RS06270	COG4608	Belongs to the ABC transporter superfamily
APS40_RS06275	COG0444	Belongs to the ABC transporter superfamily
APS40_RS06280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS06285	COG0601	transmembrane transport
APS40_RS06290	COG4166	transmembrane transport
APS40_RS06300	COG1024	Enoyl-CoA hydratase
APS40_RS06300	COG1250	3-hydroxyacyl-CoA dehydrogenase
APS40_RS06305	COG1960	acyl-CoA dehydrogenase activity
APS40_RS06310	COG0318	PFAM AMP-dependent synthetase and ligase
APS40_RS06315	COG0789	Transcriptional regulator
APS40_RS06325	COG1793	dna ligase
APS40_RS06345	COG0667	Aldo Keto reductase
APS40_RS06350	COG5265	(ABC) transporter
APS40_RS06355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APS40_RS06430	COG0071	Belongs to the small heat shock protein (HSP20) family
APS40_RS06440	COG0783	Belongs to the Dps family
APS40_RS06455	COG0069	glutamate synthase activity
APS40_RS06455	COG0070	glutamate synthase
APS40_RS06455	COG0067	glutamate synthase
APS40_RS06465	COG1764	response to oxidative stress
APS40_RS06470	COG1846	Transcriptional regulator
APS40_RS06495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APS40_RS06510	COG0330	HflC and HflK could
APS40_RS06515	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
APS40_RS06525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APS40_RS06530	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APS40_RS06560	COG0800	Aldolase
APS40_RS06565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
APS40_RS06570	COG3422	double-strand break repair
APS40_RS06575	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APS40_RS06595	COG2207	Transcriptional regulator
APS40_RS06640	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
APS40_RS06690	COG1012	belongs to the aldehyde dehydrogenase family
APS40_RS06695	COG3386	PFAM SMP-30 Gluconolaconase
APS40_RS06705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APS40_RS06710	COG1254	Belongs to the acylphosphatase family
APS40_RS06715	COG2721	sulfolactate sulfo-lyase activity
APS40_RS06745	COG0251	oxidation-reduction process
APS40_RS06750	COG0586	Pfam SNARE associated Golgi protein
APS40_RS06755	COG0586	Pfam SNARE associated Golgi protein
APS40_RS06780	COG0400	carboxylic ester hydrolase activity
APS40_RS06785	COG0346	lactoylglutathione lyase activity
APS40_RS06790	COG3622	Belongs to the hyi family
APS40_RS06795	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APS40_RS06800	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS06805	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS06815	COG1070	Carbohydrate kinase
APS40_RS06820	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS06825	COG1129	ABC transporter
APS40_RS06830	COG1879	ABC-type sugar transport system periplasmic component
APS40_RS06835	COG0673	inositol 2-dehydrogenase activity
APS40_RS06840	COG4166	transmembrane transport
APS40_RS06850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS06855	COG0444	Belongs to the ABC transporter superfamily
APS40_RS06860	COG4608	Belongs to the ABC transporter superfamily
APS40_RS06865	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS06880	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APS40_RS06890	COG1414	Transcriptional regulator
APS40_RS06905	COG1414	Transcriptional regulator
APS40_RS06920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APS40_RS06925	COG0583	DNA-binding transcription factor activity
APS40_RS06935	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APS40_RS06940	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
APS40_RS06945	COG0535	radical SAM domain protein
APS40_RS06950	COG0535	radical SAM domain protein
APS40_RS06985	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
APS40_RS07000	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS07005	COG1129	ABC transporter
APS40_RS07030	COG0673	inositol 2-dehydrogenase activity
APS40_RS07060	COG3842	ATPase activity
APS40_RS07065	COG0395	ABC-type sugar transport system, permease component
APS40_RS07070	COG1175	transmembrane transport
APS40_RS07085	COG0395	ABC-type sugar transport system, permease component
APS40_RS07090	COG1175	transmembrane transport
APS40_RS07105	COG1802	Transcriptional regulator
APS40_RS07130	COG0395	ABC-type sugar transport system, permease component
APS40_RS07145	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS07150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APS40_RS07160	COG1940	carbohydrate kinase activity
APS40_RS07165	COG0395	ABC-type sugar transport system, permease component
APS40_RS07170	COG1175	transmembrane transport
APS40_RS07180	COG2188	Transcriptional regulator
APS40_RS07190	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
APS40_RS07200	COG0395	ABC-type sugar transport system, permease component
APS40_RS07205	COG1175	transmembrane transport
APS40_RS07220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APS40_RS07235	COG2376	Dihydroxyacetone kinase
APS40_RS07245	COG2813	Specifically methylates the guanine in position
APS40_RS07260	COG0667	Aldo Keto reductase
APS40_RS07305	COG0667	Aldo Keto reductase
APS40_RS07320	COG0842	Transport permease protein
APS40_RS07325	COG1131	(ABC) transporter
APS40_RS07330	COG1793	dna ligase
APS40_RS07360	COG0739	heme binding
APS40_RS07365	COG0477	Major facilitator Superfamily
APS40_RS07375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APS40_RS07395	COG1131	(ABC) transporter
APS40_RS07410	COG2890	protein-(glutamine-N5) methyltransferase activity
APS40_RS07415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APS40_RS07420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APS40_RS07430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APS40_RS07440	COG0667	Aldo Keto reductase
APS40_RS07450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APS40_RS07455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APS40_RS07465	COG2226	methyltransferase
APS40_RS07475	COG0494	nUDIX hydrolase
APS40_RS07485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APS40_RS07495	COG1309	transcriptional regulator
APS40_RS07500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APS40_RS07540	COG0697	spore germination
APS40_RS07555	COG3034	peptidoglycan biosynthetic process
APS40_RS07560	COG3034	peptidoglycan biosynthetic process
APS40_RS07565	COG0825	malonyl-CoA metabolic process
APS40_RS07575	COG4974	Belongs to the 'phage' integrase family
APS40_RS07585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APS40_RS07590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APS40_RS07595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APS40_RS07625	COG2226	methyltransferase
APS40_RS07645	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APS40_RS07650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APS40_RS07670	COG4581	dead DEAH box helicase
APS40_RS07685	COG1329	Transcriptional regulator
APS40_RS07730	COG1764	response to oxidative stress
APS40_RS07735	COG3034	peptidoglycan biosynthetic process
APS40_RS07760	COG2378	regulation of single-species biofilm formation
APS40_RS07775	COG1733	regulation of RNA biosynthetic process
APS40_RS07785	COG0667	Aldo Keto reductase
APS40_RS07790	COG0789	Transcriptional regulator
APS40_RS07795	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS07800	COG1309	transcriptional regulator
APS40_RS07805	COG0534	Mate efflux family protein
APS40_RS07810	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS07850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APS40_RS07870	COG0400	carboxylic ester hydrolase activity
APS40_RS07880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APS40_RS07900	COG2096	Adenosyltransferase
APS40_RS07920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS40_RS07925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APS40_RS07930	COG0165	Argininosuccinate lyase
APS40_RS07940	COG0019	diaminopimelate decarboxylase activity
APS40_RS07945	COG1346	cytolysis
APS40_RS07950	COG1380	Effector of murein hydrolase LrgA
APS40_RS07960	COG2204	response regulator
APS40_RS07970	COG2884	Cell division ATP-binding protein ftsE
APS40_RS08000	COG0287	Prephenate dehydrogenase
APS40_RS08005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APS40_RS08020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APS40_RS08040	COG0114	fumarate hydratase activity
APS40_RS08045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APS40_RS08050	COG0142	geranyltranstransferase activity
APS40_RS08075	COG3339	Conserved Protein
APS40_RS08085	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
APS40_RS08095	COG0454	-acetyltransferase
APS40_RS08095	COG0456	acetyltransferase
APS40_RS08100	COG5001	Diguanylate cyclase
APS40_RS08100	COG3300	MHYT domain
APS40_RS08110	COG0683	leucine binding
APS40_RS08115	COG4221	oxidoreductase activity
APS40_RS08125	COG5654	RES domain protein
APS40_RS08170	COG0840	transmembrane signaling receptor activity
APS40_RS08175	COG0840	transmembrane signaling receptor activity
APS40_RS08180	COG0745	RESPONSE REGULATOR receiver
APS40_RS08185	COG2201	protein-glutamate methylesterase activity
APS40_RS08195	COG0840	transmembrane signaling receptor activity
APS40_RS08200	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
APS40_RS08210	COG3844	kynureninase activity
APS40_RS08225	COG4214	carbohydrate transport
APS40_RS08235	COG0657	acetylesterase activity
APS40_RS08240	COG3842	ATPase activity
APS40_RS08245	COG3639	organic phosphonate transmembrane transporter activity
APS40_RS08250	COG3639	organic phosphonate transmembrane transporter activity
APS40_RS08255	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
APS40_RS08260	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
APS40_RS08270	COG4778	phosphonate C-P lyase system protein PhnL
APS40_RS08275	COG4107	phosphonate C-P lyase system protein PhnK
APS40_RS08280	COG3627	carbon phosphorus lyase activity
APS40_RS08290	COG3626	phosphonate metabolism
APS40_RS08295	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
APS40_RS08300	COG3624	Phosphonate C-P lyase system protein PhnG
APS40_RS08305	COG2188	Transcriptional regulator
APS40_RS08310	COG0673	inositol 2-dehydrogenase activity
APS40_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS08320	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS08325	COG3254	rhamnose metabolic process
APS40_RS08330	COG2186	Transcriptional regulator
APS40_RS08335	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS08340	COG1129	ABC transporter
APS40_RS08355	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS08360	COG2186	Transcriptional regulator
APS40_RS08380	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS08385	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS08390	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS08395	COG1129	ABC transporter
APS40_RS08400	COG1879	ABC-type sugar transport system periplasmic component
APS40_RS08405	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS08410	COG1129	ABC transporter
APS40_RS08420	COG2072	flavoprotein involved in K transport
APS40_RS08435	COG3842	ATPase activity
APS40_RS08440	COG0395	ABC-type sugar transport system, permease component
APS40_RS08445	COG1175	transmembrane transport
APS40_RS08450	COG1653	transport
APS40_RS08455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APS40_RS08460	COG2072	flavoprotein involved in K transport
APS40_RS08465	COG1737	Transcriptional regulator
APS40_RS08470	COG1116	anion transmembrane transporter activity
APS40_RS08485	COG0673	inositol 2-dehydrogenase activity
APS40_RS08490	COG3964	amidohydrolase
APS40_RS08500	COG0673	inositol 2-dehydrogenase activity
APS40_RS08505	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS08515	COG1737	Transcriptional regulator
APS40_RS08515	COG0837	glucose binding
APS40_RS08520	COG1760	l-serine dehydratase
APS40_RS08545	COG0671	phosphoesterase, PA-phosphatase related
APS40_RS08550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS40_RS08560	COG2205	protein histidine kinase activity
APS40_RS08565	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
APS40_RS08570	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APS40_RS08575	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APS40_RS08585	COG0657	acetylesterase activity
APS40_RS08585	COG2755	lipolytic protein G-D-S-L family
APS40_RS08595	COG2186	Transcriptional regulator
APS40_RS08605	COG1129	ABC transporter
APS40_RS08610	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS08635	COG4608	Belongs to the ABC transporter superfamily
APS40_RS08640	COG0444	Belongs to the ABC transporter superfamily
APS40_RS08645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS08650	COG0601	transmembrane transport
APS40_RS08660	COG1349	DNA-binding transcription factor activity
APS40_RS08665	COG3959	Transketolase, thiamine diphosphate binding domain
APS40_RS08670	COG3958	Transketolase
APS40_RS08675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APS40_RS08680	COG1082	Xylose isomerase domain protein TIM barrel
APS40_RS08685	COG1312	Catalyzes the dehydration of D-mannonate
APS40_RS08695	COG2186	Transcriptional regulator
APS40_RS08700	COG0753	catalase activity
APS40_RS08725	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APS40_RS08730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APS40_RS08760	COG2010	Cytochrome c
APS40_RS08790	COG1136	(ABC) transporter
APS40_RS08790	COG0577	efflux transmembrane transporter activity
APS40_RS08795	COG1136	(ABC) transporter
APS40_RS08795	COG0577	efflux transmembrane transporter activity
APS40_RS08835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APS40_RS08835	COG0574	Belongs to the PEP-utilizing enzyme family
APS40_RS08845	COG3118	belongs to the thioredoxin family
APS40_RS08890	COG0596	Alpha beta hydrolase
APS40_RS08945	COG0045	succinate-CoA ligase (ADP-forming) activity
APS40_RS08945	COG1042	CoA-binding domain protein
APS40_RS08945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APS40_RS08950	COG0459	protein refolding
APS40_RS08965	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS08980	COG1477	protein flavinylation
APS40_RS09000	COG2205	protein histidine kinase activity
APS40_RS09035	COG0589	response to stress
APS40_RS09045	COG0071	Belongs to the small heat shock protein (HSP20) family
APS40_RS09080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APS40_RS09125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APS40_RS09125	COG3743	rRNA binding
APS40_RS09130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APS40_RS09140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APS40_RS09150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APS40_RS09155	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APS40_RS09170	COG0799	negative regulation of ribosome biogenesis
APS40_RS09175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APS40_RS09185	COG0793	Belongs to the peptidase S41A family
APS40_RS09195	COG0494	nUDIX hydrolase
APS40_RS09200	COG1794	racemase activity, acting on amino acids and derivatives
APS40_RS09210	COG0840	transmembrane signaling receptor activity
APS40_RS09215	COG0840	transmembrane signaling receptor activity
APS40_RS09220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APS40_RS09225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APS40_RS09230	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APS40_RS09240	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APS40_RS09255	COG1376	ErfK ybiS ycfS ynhG family protein
APS40_RS09265	COG4974	Belongs to the 'phage' integrase family
APS40_RS09270	COG1802	Transcriptional regulator
APS40_RS09285	COG0508	dehydrogenase complex catalyzes the overall conversion of
APS40_RS09295	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APS40_RS09300	COG0045	succinate-CoA ligase (ADP-forming) activity
APS40_RS09310	COG0039	L-malate dehydrogenase activity
APS40_RS09315	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APS40_RS09405	COG0288	reversible hydration of carbon dioxide
APS40_RS09415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APS40_RS09420	COG2081	HI0933 family
APS40_RS09460	COG1609	Transcriptional regulator
APS40_RS09465	COG4166	transmembrane transport
APS40_RS09470	COG0601	transmembrane transport
APS40_RS09475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS09480	COG0444	Belongs to the ABC transporter superfamily
APS40_RS09485	COG4608	Belongs to the ABC transporter superfamily
APS40_RS09495	COG1136	(ABC) transporter
APS40_RS09515	COG2313	pseudouridylate synthase activity
APS40_RS09520	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APS40_RS09525	COG3842	ATPase activity
APS40_RS09530	COG1176	ABC-type spermidine putrescine transport system, permease component I
APS40_RS09535	COG1177	transmembrane transport
APS40_RS09540	COG0697	spore germination
APS40_RS09545	COG0673	inositol 2-dehydrogenase activity
APS40_RS09555	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS09560	COG0673	inositol 2-dehydrogenase activity
APS40_RS09565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS40_RS09570	COG3962	Belongs to the TPP enzyme family
APS40_RS09575	COG1082	Xylose isomerase domain protein TIM barrel
APS40_RS09580	COG3718	enzyme involved in inositol metabolism
APS40_RS09590	COG0702	epimerase
APS40_RS09595	COG1733	regulation of RNA biosynthetic process
APS40_RS09605	COG3706	GGDEF domain
APS40_RS09610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APS40_RS09615	COG4208	sulfate ABC transporter
APS40_RS09620	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APS40_RS09625	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APS40_RS09630	COG1959	2 iron, 2 sulfur cluster binding
APS40_RS09635	COG4651	solute:proton antiporter activity
APS40_RS09635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APS40_RS09640	COG1063	alcohol dehydrogenase
APS40_RS09645	COG2154	pterin-4-alpha-carbinolamine dehydratase
APS40_RS09660	COG5001	Diguanylate cyclase
APS40_RS09680	COG0395	ABC-type sugar transport system, permease component
APS40_RS09690	COG1653	transport
APS40_RS09715	COG2188	Transcriptional regulator
APS40_RS09770	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APS40_RS09775	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APS40_RS09810	COG0501	Belongs to the peptidase M48B family
APS40_RS09825	COG0138	bifunctional purine biosynthesis protein purh
APS40_RS09830	COG2902	Dehydrogenase
APS40_RS09835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APS40_RS09850	COG2199	diguanylate cyclase activity
APS40_RS09865	COG0813	purine-nucleoside phosphorylase activity
APS40_RS09870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APS40_RS09875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APS40_RS09880	COG0347	Belongs to the P(II) protein family
APS40_RS09885	COG0004	ammonium transporteR
APS40_RS09890	COG0004	ammonium transporteR
APS40_RS09895	COG5265	(ABC) transporter
APS40_RS09900	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APS40_RS09905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APS40_RS09930	COG0473	3-isopropylmalate dehydrogenase activity
APS40_RS09935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APS40_RS09945	COG0066	3-isopropylmalate dehydratase activity
APS40_RS09950	COG2835	tetraacyldisaccharide 4'-kinase activity
APS40_RS09960	COG3118	belongs to the thioredoxin family
APS40_RS09970	COG0596	Alpha beta hydrolase
APS40_RS09980	COG1079	Belongs to the binding-protein-dependent transport system permease family
APS40_RS09985	COG4603	Belongs to the binding-protein-dependent transport system permease family
APS40_RS09990	COG3845	ABC transporter
APS40_RS09995	COG1744	ABC transporter substrate-binding protein PnrA-like
APS40_RS10035	COG1131	(ABC) transporter
APS40_RS10065	COG0583	DNA-binding transcription factor activity
APS40_RS10100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APS40_RS10115	COG0251	oxidation-reduction process
APS40_RS10125	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
APS40_RS10145	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS10155	COG0148	phosphopyruvate hydratase activity
APS40_RS10160	COG1609	Transcriptional regulator
APS40_RS10165	COG0129	dihydroxy-acid dehydratase activity
APS40_RS10190	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APS40_RS10195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APS40_RS10200	COG0277	FAD linked oxidase domain protein
APS40_RS10205	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
APS40_RS10210	COG1695	Transcriptional regulator
APS40_RS10215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APS40_RS10225	COG0335	large ribosomal subunit rRNA binding
APS40_RS10245	COG0336	Belongs to the RNA methyltransferase TrmD family
APS40_RS10250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APS40_RS10255	COG0228	four-way junction DNA binding
APS40_RS10260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APS40_RS10265	COG0275	rRNA processing
APS40_RS10280	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APS40_RS10285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APS40_RS10290	COG0552	protein localization to endoplasmic reticulum
APS40_RS10295	COG2917	probably involved in intracellular septation
APS40_RS10305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APS40_RS10310	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APS40_RS10315	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APS40_RS10320	COG4133	protoheme IX ABC transporter activity
APS40_RS10325	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APS40_RS10345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APS40_RS10355	COG0670	Belongs to the BI1 family
APS40_RS10360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
APS40_RS10375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APS40_RS10380	COG2814	Major facilitator Superfamily
APS40_RS10390	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APS40_RS10395	COG1280	lysine exporter protein (LysE YggA)
APS40_RS10425	COG5001	Diguanylate cyclase
APS40_RS10440	COG1217	gtp-binding protein TYPA
APS40_RS10445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APS40_RS10450	COG0586	Pfam SNARE associated Golgi protein
APS40_RS10455	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APS40_RS10465	COG1073	alpha beta
APS40_RS10475	COG0456	acetyltransferase
APS40_RS10480	COG1872	DUF167
APS40_RS10490	COG4221	oxidoreductase activity
APS40_RS10500	COG3795	YCII-related domain
APS40_RS10515	COG1846	Transcriptional regulator
APS40_RS10530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APS40_RS10535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APS40_RS10540	COG2814	Major facilitator Superfamily
APS40_RS10560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APS40_RS10570	COG0393	Putative heavy-metal-binding
APS40_RS10575	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APS40_RS10590	COG0587	DNA-directed DNA polymerase activity
APS40_RS10595	COG0835	chemotaxis
APS40_RS10600	COG2198	Histidine kinase
APS40_RS10600	COG0643	Histidine kinase
APS40_RS10605	COG0745	RESPONSE REGULATOR receiver
APS40_RS10615	COG1024	Enoyl-CoA hydratase
APS40_RS10625	COG0604	alcohol dehydrogenase
APS40_RS10635	COG1131	(ABC) transporter
APS40_RS10685	COG0745	RESPONSE REGULATOR receiver
APS40_RS10690	COG1609	Transcriptional regulator
APS40_RS10700	COG0395	ABC-type sugar transport system, permease component
APS40_RS10710	COG1501	Belongs to the glycosyl hydrolase 31 family
APS40_RS10715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APS40_RS10725	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APS40_RS10730	COG0495	leucyl-tRNA aminoacylation
APS40_RS10740	COG1466	dna polymerase III delta subunit
APS40_RS10760	COG0445	tRNA wobble uridine modification
APS40_RS10765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APS40_RS10770	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APS40_RS10775	COG1981	membrane
APS40_RS10780	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APS40_RS10790	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APS40_RS10795	COG0237	dephospho-CoA kinase activity
APS40_RS10800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APS40_RS10805	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APS40_RS10810	COG3030	protein affecting phage T7 exclusion by the F plasmid
APS40_RS10825	COG1396	sequence-specific DNA binding
APS40_RS10840	COG1132	(ABC) transporter
APS40_RS10850	COG0436	Aminotransferase
APS40_RS10855	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APS40_RS10865	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APS40_RS10870	COG0131	Imidazoleglycerol-phosphate dehydratase
APS40_RS10880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APS40_RS10885	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APS40_RS10900	COG0107	imidazoleglycerol-phosphate synthase activity
APS40_RS10905	COG0140	phosphoribosyl-ATP diphosphatase activity
APS40_RS10910	COG1072	(Pantothenic acid kinase))
APS40_RS10915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS40_RS10940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APS40_RS10945	COG0588	phosphoglycerate mutase activity
APS40_RS10950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APS40_RS10955	COG0284	orotidine-5'-phosphate decarboxylase activity
APS40_RS10975	COG0484	heat shock protein binding
APS40_RS10980	COG0657	acetylesterase activity
APS40_RS11015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APS40_RS11020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APS40_RS11025	COG1420	regulation of RNA biosynthetic process
APS40_RS11035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APS40_RS11040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APS40_RS11045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APS40_RS11050	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
APS40_RS11055	COG0402	S-adenosylhomocysteine deaminase activity
APS40_RS11070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APS40_RS11090	COG4941	Belongs to the sigma-70 factor family
APS40_RS11110	COG1609	Transcriptional regulator
APS40_RS11130	COG0745	RESPONSE REGULATOR receiver
APS40_RS11135	COG2205	protein histidine kinase activity
APS40_RS11145	COG0667	Aldo Keto reductase
APS40_RS11150	COG0477	Major facilitator Superfamily
APS40_RS11160	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
APS40_RS11165	COG0779	Required for maturation of 30S ribosomal subunits
APS40_RS11180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APS40_RS11195	COG0740	serine-type endopeptidase activity
APS40_RS11205	COG0640	Transcriptional regulator
APS40_RS11210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APS40_RS11235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APS40_RS11240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APS40_RS11245	COG3920	Histidine kinase
APS40_RS11250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APS40_RS11255	COG1185	polyribonucleotide nucleotidyltransferase activity
APS40_RS11265	COG1309	transcriptional regulator
APS40_RS11290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APS40_RS11295	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APS40_RS11300	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APS40_RS11310	COG1253	flavin adenine dinucleotide binding
APS40_RS11315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APS40_RS11320	COG1702	phosphate starvation-inducible protein PhoH
APS40_RS11325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APS40_RS11355	COG1214	PFAM Peptidase M22, glycoprotease
APS40_RS11360	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
APS40_RS11370	COG0180	Tryptophanyl-tRNA synthetase
APS40_RS11375	COG1063	alcohol dehydrogenase
APS40_RS11380	COG0156	8-amino-7-oxononanoate synthase activity
APS40_RS11395	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
APS40_RS11400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APS40_RS11405	COG3507	Belongs to the glycosyl hydrolase 43 family
APS40_RS11415	COG1070	Carbohydrate kinase
APS40_RS11420	COG1609	Transcriptional regulator
APS40_RS11435	COG0596	Alpha beta hydrolase
APS40_RS11440	COG2378	regulation of single-species biofilm formation
APS40_RS11445	COG0596	Alpha beta hydrolase
APS40_RS11475	COG3655	Transcriptional regulator
APS40_RS11485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APS40_RS11515	COG1609	Transcriptional regulator
APS40_RS11520	COG1653	transport
APS40_RS11530	COG0395	ABC-type sugar transport system, permease component
APS40_RS11540	COG1621	beta-fructofuranosidase activity
APS40_RS11555	COG3179	chitinase
APS40_RS11580	COG0606	chelatase, subunit chli
APS40_RS11600	COG1414	Transcriptional regulator
APS40_RS11605	COG4209	transmembrane transport
APS40_RS11610	COG0395	ABC-type sugar transport system, permease component
APS40_RS11625	COG3757	hydrolase, family 25
APS40_RS11630	COG2095	MarC family integral membrane protein
APS40_RS11655	COG0792	nuclease activity
APS40_RS11660	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APS40_RS11675	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
APS40_RS11680	COG2259	Doxx family
APS40_RS11685	COG0354	folic acid binding
APS40_RS11690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APS40_RS11705	COG1051	belongs to the nudix hydrolase family
APS40_RS11710	COG2135	peptidase activity
APS40_RS11730	COG0432	Pfam Uncharacterised protein family UPF0047
APS40_RS11740	COG1957	nucleoside hydrolase
APS40_RS11750	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
APS40_RS11755	COG1609	Transcriptional regulator
APS40_RS11770	COG0395	ABC-type sugar transport system, permease component
APS40_RS11775	COG1175	transmembrane transport
APS40_RS11785	COG0277	FAD linked oxidase domain protein
APS40_RS11790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APS40_RS11820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APS40_RS11835	COG1999	signal sequence binding
APS40_RS11840	COG1722	exodeoxyribonuclease VII activity
APS40_RS11845	COG0123	including yeast histone deacetylase and acetoin utilization protein
APS40_RS11850	COG0009	L-threonylcarbamoyladenylate synthase
APS40_RS11855	COG0484	heat shock protein binding
APS40_RS11860	COG0259	pyridoxamine-phosphate oxidase activity
APS40_RS11870	COG0501	Belongs to the peptidase M48B family
APS40_RS11880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APS40_RS11905	COG2205	protein histidine kinase activity
APS40_RS11915	COG4964	Belongs to the GSP D family
APS40_RS11930	COG1737	Transcriptional regulator
APS40_RS11960	COG4172	Belongs to the ABC transporter superfamily
APS40_RS11970	COG1609	Transcriptional regulator
APS40_RS11985	COG0395	ABC-type sugar transport system, permease component
APS40_RS11990	COG1653	transport
APS40_RS12010	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
APS40_RS12035	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APS40_RS12040	COG0673	inositol 2-dehydrogenase activity
APS40_RS12045	COG0395	ABC-type sugar transport system, permease component
APS40_RS12050	COG1175	transmembrane transport
APS40_RS12060	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APS40_RS12070	COG1414	Transcriptional regulator
APS40_RS12095	COG0601	transmembrane transport
APS40_RS12100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS12105	COG0444	Belongs to the ABC transporter superfamily
APS40_RS12110	COG4608	Belongs to the ABC transporter superfamily
APS40_RS12115	COG4166	transmembrane transport
APS40_RS12130	COG3634	alkyl hydroperoxide reductase activity
APS40_RS12135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS40_RS12155	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
APS40_RS12165	COG0295	cytidine deaminase activity
APS40_RS12170	COG0402	S-adenosylhomocysteine deaminase activity
APS40_RS12180	COG1744	ABC transporter substrate-binding protein PnrA-like
APS40_RS12185	COG3845	ABC transporter
APS40_RS12190	COG4603	Belongs to the binding-protein-dependent transport system permease family
APS40_RS12195	COG1079	Belongs to the binding-protein-dependent transport system permease family
APS40_RS12220	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS12225	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS12230	COG1129	ABC transporter
APS40_RS12235	COG1879	ABC-type sugar transport system periplasmic component
APS40_RS12245	COG3347	Dehydrogenase
APS40_RS12245	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS12250	COG4952	isomerase
APS40_RS12265	COG0583	DNA-binding transcription factor activity
APS40_RS12275	COG0738	Major facilitator superfamily
APS40_RS12280	COG0738	Major facilitator superfamily
APS40_RS12295	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
APS40_RS12320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APS40_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS12330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APS40_RS12335	COG2207	Transcriptional regulator
APS40_RS12345	COG1742	UPF0060 membrane protein
APS40_RS12360	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APS40_RS12375	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APS40_RS12380	COG0268	Binds directly to 16S ribosomal RNA
APS40_RS12385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APS40_RS12390	COG2226	methyltransferase
APS40_RS12395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APS40_RS12405	COG0756	dUTP diphosphatase activity
APS40_RS12420	COG0667	Aldo Keto reductase
APS40_RS12425	COG0488	(ABC) transporter
APS40_RS12430	COG1959	2 iron, 2 sulfur cluster binding
APS40_RS12435	COG0667	Aldo Keto reductase
APS40_RS12445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APS40_RS12465	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS12480	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS12485	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS12505	COG3534	alpha-L-arabinofuranosidase
APS40_RS12550	COG1609	Transcriptional regulator
APS40_RS12565	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS12590	COG3842	ATPase activity
APS40_RS12595	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS12600	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS12605	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS12630	COG1312	Catalyzes the dehydration of D-mannonate
APS40_RS12640	COG1175	transmembrane transport
APS40_RS12670	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS12675	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS12680	COG1414	Transcriptional regulator
APS40_RS12685	COG3254	rhamnose metabolic process
APS40_RS12690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APS40_RS12705	COG1294	oxidase, subunit
APS40_RS12715	COG4988	ABC transporter
APS40_RS12720	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APS40_RS12735	COG1136	(ABC) transporter
APS40_RS12740	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
APS40_RS12745	COG2223	nitrite transmembrane transporter activity
APS40_RS12775	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
APS40_RS12785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APS40_RS12815	COG0450	alkyl hydroperoxide reductase
APS40_RS12850	COG2885	chlorophyll binding
APS40_RS12875	COG0387	Pfam Sodium calcium exchanger
APS40_RS12915	COG0116	Belongs to the methyltransferase superfamily
APS40_RS12920	COG0583	DNA-binding transcription factor activity
APS40_RS12930	COG1597	lipid kinase activity
APS40_RS12935	COG2808	Putative FMN-binding domain
APS40_RS12945	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
APS40_RS12970	COG0583	DNA-binding transcription factor activity
APS40_RS12975	COG1054	Belongs to the UPF0176 family
APS40_RS12980	COG0667	Aldo Keto reductase
APS40_RS12990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APS40_RS12990	COG0072	phenylalanine-tRNA ligase activity
APS40_RS13000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APS40_RS13005	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APS40_RS13010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APS40_RS13025	COG0583	DNA-binding transcription factor activity
APS40_RS13040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APS40_RS13070	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APS40_RS13080	COG1968	undecaprenyl-diphosphatase activity
APS40_RS13085	COG3142	Participates in the control of copper homeostasis
APS40_RS13090	COG1940	carbohydrate kinase activity
APS40_RS13100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS40_RS13105	COG1446	asparaginase
APS40_RS13115	COG0765	amino acid transport
APS40_RS13120	COG0765	amino acid transport
APS40_RS13125	COG1388	LysM domain
APS40_RS13125	COG1376	ErfK ybiS ycfS ynhG family protein
APS40_RS13145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS40_RS13155	COG1215	transferase activity, transferring glycosyl groups
APS40_RS13160	COG1215	transferase activity, transferring glycosyl groups
APS40_RS13180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS40_RS13185	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APS40_RS13190	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
APS40_RS13195	COG1137	ATPase activity
APS40_RS13210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APS40_RS13220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APS40_RS13230	COG2873	o-acetylhomoserine
APS40_RS13235	COG1247	-acetyltransferase
APS40_RS13265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APS40_RS13280	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS13300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS40_RS13315	COG0601	transmembrane transport
APS40_RS13325	COG0444	Belongs to the ABC transporter superfamily
APS40_RS13330	COG4608	Belongs to the ABC transporter superfamily
APS40_RS13335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APS40_RS13345	COG1304	FMN binding
APS40_RS13360	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APS40_RS13370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APS40_RS13395	COG2378	regulation of single-species biofilm formation
APS40_RS13405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APS40_RS13415	COG1904	glucuronate isomerase
APS40_RS13420	COG1917	Cupin 2, conserved barrel domain protein
APS40_RS13435	COG0443	Heat shock 70 kDa protein
APS40_RS13475	COG0640	Transcriptional regulator
APS40_RS13505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APS40_RS13510	COG0539	negative regulation of cytoplasmic translation
APS40_RS13530	COG2826	transposase and inactivated derivatives, IS30 family
APS40_RS13535	COG0616	signal peptide processing
APS40_RS13550	COG0135	phosphoribosylanthranilate isomerase activity
APS40_RS13555	COG0133	tryptophan synthase activity
APS40_RS13565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APS40_RS13570	COG0285	dihydrofolate synthase activity
APS40_RS13585	COG3118	belongs to the thioredoxin family
APS40_RS13590	COG1074	ATP-dependent DNA helicase activity
APS40_RS13600	COG0802	atpase or kinase
APS40_RS13605	COG2205	protein histidine kinase activity
APS40_RS13620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS40_RS13625	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APS40_RS13625	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APS40_RS13630	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APS40_RS13635	COG0642	Histidine kinase
APS40_RS13640	COG0745	RESPONSE REGULATOR receiver
APS40_RS13645	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
APS40_RS13655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APS40_RS13700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APS40_RS13700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APS40_RS13725	COG2197	response regulator
APS40_RS13745	COG0564	pseudouridine synthase activity
APS40_RS13795	COG3938	Belongs to the proline racemase family
APS40_RS13800	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS13805	COG3938	Belongs to the proline racemase family
APS40_RS13810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS40_RS13830	COG0559	Belongs to the binding-protein-dependent transport system permease family
APS40_RS13840	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS13850	COG0395	ABC-type sugar transport system, permease component
APS40_RS13860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APS40_RS13905	COG0395	ABC-type sugar transport system, permease component
APS40_RS13930	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS13945	COG0745	RESPONSE REGULATOR receiver
APS40_RS13950	COG0643	Histidine kinase
APS40_RS13950	COG2198	Histidine kinase
APS40_RS13955	COG0835	chemotaxis
APS40_RS13960	COG0840	transmembrane signaling receptor activity
APS40_RS13970	COG0835	chemotaxis
APS40_RS13980	COG2201	protein-glutamate methylesterase activity
APS40_RS14000	COG1609	Transcriptional regulator
APS40_RS14005	COG4209	transmembrane transport
APS40_RS14010	COG0395	ABC-type sugar transport system, permease component
APS40_RS14020	COG1397	ADP-ribosylglycohydrolase
APS40_RS14030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APS40_RS14040	COG3300	MHYT domain
APS40_RS14040	COG5001	Diguanylate cyclase
APS40_RS14045	COG2207	Transcriptional regulator
APS40_RS14050	COG1486	melibiose metabolic process
APS40_RS14060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APS40_RS14080	COG5001	Diguanylate cyclase
APS40_RS14095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APS40_RS14100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APS40_RS14105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APS40_RS14110	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APS40_RS14120	COG2852	Protein conserved in bacteria
APS40_RS14140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APS40_RS14145	COG1309	transcriptional regulator
APS40_RS14170	COG0697	spore germination
APS40_RS14195	COG0493	'glutamate synthase
APS40_RS14200	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APS40_RS14215	COG3454	Phosphonate metabolism
APS40_RS14220	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
APS40_RS14250	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS14260	COG0667	Aldo Keto reductase
APS40_RS14265	COG0346	lactoylglutathione lyase activity
APS40_RS14270	COG0747	negative chemotaxis
APS40_RS14275	COG0601	transmembrane transport
APS40_RS14280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS14285	COG0444	Belongs to the ABC transporter superfamily
APS40_RS14290	COG4608	Belongs to the ABC transporter superfamily
APS40_RS14295	COG5001	Diguanylate cyclase
APS40_RS14305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APS40_RS14310	COG1121	(ABC) transporter
APS40_RS14325	COG3634	alkyl hydroperoxide reductase activity
APS40_RS14390	COG1301	dicarboxylic acid transport
APS40_RS14395	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APS40_RS14455	COG1492	cobalamin metabolic process
APS40_RS14470	COG2971	BadF BadG BcrA BcrD
APS40_RS14475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APS40_RS14480	COG0363	glucosamine-6-phosphate deaminase activity
APS40_RS14485	COG0129	dihydroxy-acid dehydratase activity
APS40_RS14495	COG1846	Transcriptional regulator
APS40_RS14510	COG0640	Transcriptional regulator
APS40_RS14550	COG3845	ABC transporter
APS40_RS14555	COG4603	Belongs to the binding-protein-dependent transport system permease family
APS40_RS14560	COG1079	Belongs to the binding-protein-dependent transport system permease family
APS40_RS14565	COG0295	cytidine deaminase activity
APS40_RS14570	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APS40_RS14575	COG1012	belongs to the aldehyde dehydrogenase family
APS40_RS14585	COG1566	PFAM secretion protein HlyD family protein
APS40_RS14605	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
APS40_RS14610	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
APS40_RS14615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APS40_RS14635	COG4964	Belongs to the GSP D family
APS40_RS14655	COG4964	Belongs to the GSP D family
APS40_RS14685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APS40_RS14695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APS40_RS14700	COG3474	cytochrome
APS40_RS14705	COG1605	Chorismate mutase
APS40_RS14705	COG0077	Prephenate dehydratase
APS40_RS14720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APS40_RS14725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APS40_RS14730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APS40_RS14740	COG3300	MHYT domain
APS40_RS14740	COG5001	Diguanylate cyclase
APS40_RS14750	COG0242	peptide deformylase activity
APS40_RS14760	COG0101	tRNA pseudouridine synthase activity
APS40_RS14780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APS40_RS14785	COG2171	N-acyltransferase activity
APS40_RS14805	COG0477	Major facilitator Superfamily
APS40_RS14820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APS40_RS14835	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APS40_RS14840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APS40_RS14845	COG0519	Catalyzes the synthesis of GMP from XMP
APS40_RS14850	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APS40_RS14860	COG0706	membrane insertase activity
APS40_RS14870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APS40_RS14880	COG2205	protein histidine kinase activity
APS40_RS14900	COG2084	Dehydrogenase
APS40_RS14905	COG3622	Belongs to the hyi family
APS40_RS14915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS14920	COG0601	transmembrane transport
APS40_RS14930	COG0747	negative chemotaxis
APS40_RS14935	COG1609	Transcriptional regulator
APS40_RS14940	COG1609	Transcriptional regulator
APS40_RS14950	COG1653	transport
APS40_RS14960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS40_RS14970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APS40_RS14990	COG1175	transmembrane transport
APS40_RS15005	COG5002	protein histidine kinase activity
APS40_RS15015	COG0745	RESPONSE REGULATOR receiver
APS40_RS15020	COG1396	sequence-specific DNA binding
APS40_RS15020	COG3800	Transcriptional regulator
APS40_RS15035	COG4603	Belongs to the binding-protein-dependent transport system permease family
APS40_RS15105	COG3391	amine dehydrogenase activity
APS40_RS15130	COG4608	Belongs to the ABC transporter superfamily
APS40_RS15135	COG0444	Belongs to the ABC transporter superfamily
APS40_RS15140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS15145	COG0601	transmembrane transport
APS40_RS15155	COG2205	protein histidine kinase activity
APS40_RS15185	COG1609	Transcriptional regulator
APS40_RS15190	COG1129	ABC transporter
APS40_RS15195	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS15200	COG1879	ABC-type sugar transport system periplasmic component
APS40_RS15225	COG0395	ABC-type sugar transport system, permease component
APS40_RS15230	COG1175	transmembrane transport
APS40_RS15240	COG3842	ATPase activity
APS40_RS15245	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS15285	COG0395	ABC-type sugar transport system, permease component
APS40_RS15295	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS15310	COG3833	ABC-type maltose transport systems, permease component
APS40_RS15315	COG1175	transmembrane transport
APS40_RS15335	COG3454	Phosphonate metabolism
APS40_RS15350	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS15355	COG1172	Belongs to the binding-protein-dependent transport system permease family
APS40_RS15360	COG1129	ABC transporter
APS40_RS15365	COG1879	ABC-type sugar transport system periplasmic component
APS40_RS15370	COG2188	Transcriptional regulator
APS40_RS15375	COG0508	dehydrogenase complex catalyzes the overall conversion of
APS40_RS15385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APS40_RS15395	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS15405	COG3959	Transketolase, thiamine diphosphate binding domain
APS40_RS15410	COG3958	Transketolase
APS40_RS15415	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS15420	COG1609	Transcriptional regulator
APS40_RS15435	COG1129	ABC transporter
APS40_RS15440	COG2017	converts alpha-aldose to the beta-anomer
APS40_RS15450	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS15460	COG4178	(ABC) transporter
APS40_RS15465	COG4771	TonB-dependent receptor
APS40_RS15475	COG0748	coenzyme F420 binding
APS40_RS15505	COG2304	oxidoreductase activity
APS40_RS15515	COG0714	Associated with various cellular activities
APS40_RS15520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APS40_RS15530	COG2943	transferase activity, transferring hexosyl groups
APS40_RS15535	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
APS40_RS15555	COG0596	Alpha beta hydrolase
APS40_RS15585	COG0514	ATP-dependent DNA helicase (RecQ)
APS40_RS15595	COG1643	Atp-dependent helicase
APS40_RS15605	COG5001	Diguanylate cyclase
APS40_RS15610	COG2309	aminopeptidase activity
APS40_RS15630	COG5564	TIM-barrel signal transduction protein
APS40_RS15650	COG1175	transmembrane transport
APS40_RS15665	COG3842	ATPase activity
APS40_RS15670	COG3842	ATPase activity
APS40_RS15680	COG0673	inositol 2-dehydrogenase activity
APS40_RS15685	COG1082	Xylose isomerase domain protein TIM barrel
APS40_RS15690	COG2706	6-phosphogluconolactonase activity
APS40_RS15695	COG2223	nitrite transmembrane transporter activity
APS40_RS15700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS40_RS15705	COG1725	Transcriptional regulator
APS40_RS15730	COG1063	alcohol dehydrogenase
APS40_RS15760	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS15775	COG0583	DNA-binding transcription factor activity
APS40_RS15780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APS40_RS15785	COG0246	Mannitol dehydrogenase
APS40_RS15800	COG1012	belongs to the aldehyde dehydrogenase family
APS40_RS15805	COG0174	glutamine synthetase
APS40_RS15810	COG0531	amino acid
APS40_RS15820	COG2326	polyphosphate kinase activity
APS40_RS15825	COG5002	protein histidine kinase activity
APS40_RS15830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APS40_RS15835	COG0573	inorganic phosphate transmembrane transporter activity
APS40_RS15840	COG0581	inorganic phosphate transmembrane transporter activity
APS40_RS15845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APS40_RS15850	COG0704	Plays a role in the regulation of phosphate uptake
APS40_RS15855	COG0745	RESPONSE REGULATOR receiver
APS40_RS15860	COG0154	amidase activity
APS40_RS15875	COG0412	Dienelactone hydrolase
APS40_RS15895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APS40_RS15900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APS40_RS15920	COG1136	(ABC) transporter
APS40_RS15920	COG0577	efflux transmembrane transporter activity
APS40_RS15925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS40_RS15965	COG0717	Belongs to the dCTP deaminase family
APS40_RS16010	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
APS40_RS16010	COG1672	PFAM Archaeal ATPase
APS40_RS16015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APS40_RS16020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APS40_RS16025	COG1845	cytochrome c oxidase, subunit III
APS40_RS16065	COG1175	transmembrane transport
APS40_RS16070	COG0395	ABC-type sugar transport system, permease component
APS40_RS16090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APS40_RS16095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS40_RS16105	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
APS40_RS16115	COG0167	dihydroorotate dehydrogenase activity
APS40_RS16120	COG0534	Mate efflux family protein
APS40_RS16130	COG1201	RNA secondary structure unwinding
APS40_RS16150	COG0730	response to heat
APS40_RS16180	COG2205	protein histidine kinase activity
APS40_RS16185	COG1970	mechanosensitive ion channel activity
APS40_RS16200	COG0156	8-amino-7-oxononanoate synthase activity
APS40_RS16220	COG2885	chlorophyll binding
APS40_RS16230	COG1388	LysM domain
APS40_RS16230	COG1376	ErfK ybiS ycfS ynhG family protein
APS40_RS16245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APS40_RS16250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APS40_RS16265	COG1072	(Pantothenic acid kinase))
APS40_RS16275	COG4608	Belongs to the ABC transporter superfamily
APS40_RS16280	COG0444	Belongs to the ABC transporter superfamily
APS40_RS16285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS16290	COG0601	transmembrane transport
APS40_RS16295	COG4166	transmembrane transport
APS40_RS16310	COG4821	SIS domain
APS40_RS16315	COG1653	transport
APS40_RS16320	COG1175	transmembrane transport
APS40_RS16325	COG0395	ABC-type sugar transport system, permease component
APS40_RS16335	COG0745	RESPONSE REGULATOR receiver
APS40_RS16340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS40_RS16360	COG1320	monovalent cation:proton antiporter activity
APS40_RS16365	COG2212	antiporter activity
APS40_RS16370	COG1863	multisubunit Na H antiporter MnhE subunit
APS40_RS16375	COG0651	ATP synthesis coupled electron transport
APS40_RS16380	COG1006	Multisubunit Na H antiporter MnhC subunit
APS40_RS16385	COG2111	Na H antiporter
APS40_RS16385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APS40_RS16395	COG2249	NAD(P)H dehydrogenase (quinone) activity
APS40_RS16410	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
APS40_RS16415	COG0424	maF-like protein
APS40_RS16420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APS40_RS16425	COG5328	Belongs to the UPF0262 family
APS40_RS16430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APS40_RS16440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APS40_RS16560	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APS40_RS16575	COG0601	transmembrane transport
APS40_RS16580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS16585	COG1454	alcohol dehydrogenase
APS40_RS16590	COG2186	Transcriptional regulator
APS40_RS16600	COG4172	Belongs to the ABC transporter superfamily
APS40_RS16620	COG2897	thiosulfate sulfurtransferase activity
APS40_RS16640	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APS40_RS16655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS16660	COG0601	transmembrane transport
APS40_RS16665	COG0747	negative chemotaxis
APS40_RS16670	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APS40_RS16675	COG1737	Transcriptional regulator
APS40_RS16695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS16700	COG0444	Belongs to the ABC transporter superfamily
APS40_RS16715	COG4608	Belongs to the ABC transporter superfamily
APS40_RS16725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS16730	COG0601	transmembrane transport
APS40_RS16735	COG0747	negative chemotaxis
APS40_RS16750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APS40_RS16760	COG1653	transport
APS40_RS16770	COG0395	ABC-type sugar transport system, permease component
APS40_RS16775	COG3842	ATPase activity
APS40_RS16780	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS16790	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS16795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APS40_RS16805	COG2308	Evidence 4 Homologs of previously reported genes of
APS40_RS16820	COG0679	Auxin Efflux Carrier
APS40_RS16835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APS40_RS16840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APS40_RS16845	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS16850	COG0366	Alpha amylase catalytic
APS40_RS16865	COG1473	amidohydrolase
APS40_RS16870	COG2086	electron transfer activity
APS40_RS16885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APS40_RS16890	COG0489	protein tyrosine kinase activity
APS40_RS16915	COG0730	response to heat
APS40_RS16920	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APS40_RS16925	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APS40_RS16930	COG0124	histidyl-tRNA synthetase
APS40_RS16945	COG2818	Glycosylase
APS40_RS16950	COG0745	RESPONSE REGULATOR receiver
APS40_RS16960	COG1388	LysM domain
APS40_RS16960	COG1376	ErfK ybiS ycfS ynhG family protein
APS40_RS16990	COG1840	ABC-type Fe3 transport system, periplasmic component
APS40_RS16995	COG1840	ABC-type Fe3 transport system, periplasmic component
APS40_RS17000	COG1178	ABC-type Fe3 transport system permease component
APS40_RS17005	COG0601	transmembrane transport
APS40_RS17015	COG0366	Alpha amylase catalytic
APS40_RS17020	COG0459	protein refolding
APS40_RS17030	COG0463	Glycosyl transferase, family 2
APS40_RS17040	COG2204	response regulator
APS40_RS17055	COG0196	riboflavin kinase activity
APS40_RS17060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APS40_RS17065	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APS40_RS17075	COG1187	pseudouridine synthase activity
APS40_RS17080	COG0742	ribosomal rna small subunit methyltransferase
APS40_RS17090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APS40_RS17095	COG0590	tRNA wobble adenosine to inosine editing
APS40_RS17105	COG1752	Esterase of the alpha-beta hydrolase superfamily
APS40_RS17110	COG0151	Belongs to the GarS family
APS40_RS17115	COG1570	exodeoxyribonuclease VII activity
APS40_RS17135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APS40_RS17145	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APS40_RS17150	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APS40_RS17150	COG0517	IMP dehydrogenase activity
APS40_RS17175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APS40_RS17185	COG3572	ergothioneine biosynthetic process
APS40_RS17210	COG1846	Transcriptional regulator
APS40_RS17215	COG0583	DNA-binding transcription factor activity
APS40_RS17235	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APS40_RS17240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APS40_RS17245	COG0109	protoheme IX farnesyltransferase activity
APS40_RS17250	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
APS40_RS17270	COG3346	SURF1 family
APS40_RS17280	COG0612	Peptidase, M16
APS40_RS17295	COG1678	Uncharacterized ACR, COG1678
APS40_RS17305	COG0678	peroxiredoxin activity
APS40_RS17305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APS40_RS17315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APS40_RS17320	COG0509	glycine decarboxylation via glycine cleavage system
APS40_RS17325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APS40_RS17330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APS40_RS17345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APS40_RS17350	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APS40_RS17355	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APS40_RS17360	COG0356	it plays a direct role in the translocation of protons across the membrane
APS40_RS17370	COG1196	nuclear chromosome segregation
APS40_RS17375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APS40_RS17385	COG1194	a g-specific adenine glycosylase
APS40_RS17390	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APS40_RS17395	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APS40_RS17410	COG0751	glycine-tRNA ligase activity
APS40_RS17420	COG1704	LemA family
APS40_RS17430	COG0521	Mo-molybdopterin cofactor biosynthetic process
APS40_RS17450	COG1573	uracil-dna glycosylase
APS40_RS17465	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APS40_RS17475	COG0142	geranyltranstransferase activity
APS40_RS17500	COG0752	glycyl-tRNA synthetase alpha subunit
APS40_RS17515	COG0328	RNA-DNA hybrid ribonuclease activity
APS40_RS17525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APS40_RS17530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APS40_RS17530	COG0574	Belongs to the PEP-utilizing enzyme family
APS40_RS17540	COG2249	NAD(P)H dehydrogenase (quinone) activity
APS40_RS17550	COG0402	S-adenosylhomocysteine deaminase activity
APS40_RS17555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APS40_RS17580	COG2986	histidine ammonia-lyase
APS40_RS17585	COG1732	Glycine betaine
APS40_RS17590	COG1174	glycine betaine transport
APS40_RS17595	COG1125	glycine betaine transport
APS40_RS17600	COG1174	glycine betaine transport
APS40_RS17605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APS40_RS17625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
APS40_RS17630	COG4166	transmembrane transport
APS40_RS17635	COG4172	Belongs to the ABC transporter superfamily
APS40_RS17640	COG4239	(ABC) transporter, permease
APS40_RS17645	COG4174	ABC transporter (Permease)
APS40_RS17655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS40_RS17690	COG0433	COG0433 Predicted ATPase
APS40_RS17700	COG1733	regulation of RNA biosynthetic process
APS40_RS17715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APS40_RS17725	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APS40_RS17730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APS40_RS17730	COG2111	Na H antiporter
APS40_RS17735	COG2111	Na H antiporter
APS40_RS17740	COG1006	Multisubunit Na H antiporter MnhC subunit
APS40_RS17745	COG0651	ATP synthesis coupled electron transport
APS40_RS17750	COG1863	multisubunit Na H antiporter MnhE subunit
APS40_RS17755	COG2212	antiporter activity
APS40_RS17760	COG1320	monovalent cation:proton antiporter activity
APS40_RS17765	COG4957	zinc ion binding
APS40_RS17775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APS40_RS17790	COG2166	iron-sulfur cluster assembly
APS40_RS17800	COG2205	protein histidine kinase activity
APS40_RS17835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APS40_RS17840	COG2983	Belongs to the UPF0260 family
APS40_RS17845	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS17850	COG3250	beta-galactosidase activity
APS40_RS17865	COG0395	ABC-type sugar transport system, permease component
APS40_RS17870	COG4209	transmembrane transport
APS40_RS17875	COG1609	Transcriptional regulator
APS40_RS17880	COG1473	amidohydrolase
APS40_RS17910	COG0395	ABC-type sugar transport system, permease component
APS40_RS17915	COG1175	transmembrane transport
APS40_RS17925	COG1802	Transcriptional regulator
APS40_RS17950	COG0395	ABC-type sugar transport system, permease component
APS40_RS17955	COG1175	transmembrane transport
APS40_RS17960	COG2182	Extracellular solute-binding protein
APS40_RS17965	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APS40_RS17995	COG0583	DNA-binding transcription factor activity
APS40_RS18060	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
APS40_RS18065	COG1138	Cytochrome C-type biogenesis protein
APS40_RS18070	COG3088	subunit of a heme lyase
APS40_RS18080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APS40_RS18085	COG0745	RESPONSE REGULATOR receiver
APS40_RS18090	COG0642	Histidine kinase
APS40_RS18100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
APS40_RS18110	COG2378	regulation of single-species biofilm formation
APS40_RS18125	COG2202	Pas domain
APS40_RS18125	COG2205	protein histidine kinase activity
APS40_RS18130	COG0308	aminopeptidase N
APS40_RS18135	COG1132	(ABC) transporter
APS40_RS18140	COG1132	(ABC) transporter
APS40_RS18145	COG1132	(ABC) transporter
APS40_RS18170	COG0640	Transcriptional regulator
APS40_RS18185	COG1733	regulation of RNA biosynthetic process
APS40_RS18195	COG0697	spore germination
APS40_RS18200	COG0697	spore germination
APS40_RS18220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APS40_RS18225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APS40_RS18230	COG1121	(ABC) transporter
APS40_RS18235	COG0803	Belongs to the bacterial solute-binding protein 9 family
APS40_RS18240	COG1914	H( )-stimulated, divalent metal cation uptake system
APS40_RS18250	COG1278	Cold shock
APS40_RS18255	COG1252	NADH dehydrogenase
APS40_RS18260	COG1733	regulation of RNA biosynthetic process
APS40_RS18270	COG1566	PFAM secretion protein HlyD family protein
APS40_RS18280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APS40_RS18310	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
APS40_RS18325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APS40_RS18330	COG2205	protein histidine kinase activity
APS40_RS18330	COG2202	Pas domain
APS40_RS18340	COG1522	sequence-specific DNA binding
APS40_RS18345	COG1073	alpha beta
APS40_RS18360	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS18365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APS40_RS18370	COG1376	ErfK ybiS ycfS ynhG family protein
APS40_RS18375	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APS40_RS18390	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
APS40_RS18415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APS40_RS18430	COG0215	cysteine-tRNA ligase activity
APS40_RS18465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APS40_RS18470	COG1652	LysM domain
APS40_RS18480	COG5265	(ABC) transporter
APS40_RS18490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APS40_RS18520	COG3800	Transcriptional regulator
APS40_RS18520	COG1396	sequence-specific DNA binding
APS40_RS18525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APS40_RS18530	COG2852	Protein conserved in bacteria
APS40_RS18535	COG4770	biotin carboxylase activity
APS40_RS18540	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
APS40_RS18540	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
APS40_RS18545	COG0346	lactoylglutathione lyase activity
APS40_RS18585	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APS40_RS18590	COG1091	dTDP-4-dehydrorhamnose reductase activity
APS40_RS18605	COG1869	D-ribose catabolic process
APS40_RS18615	COG1175	transmembrane transport
APS40_RS18635	COG1363	Peptidase, m42
APS40_RS18640	COG0434	BtpA family
APS40_RS18650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APS40_RS18655	COG4821	SIS domain
APS40_RS18660	COG2188	Transcriptional regulator
APS40_RS18670	COG0395	ABC-type sugar transport system, permease component
APS40_RS18675	COG1175	transmembrane transport
APS40_RS18680	COG2182	Extracellular solute-binding protein
APS40_RS18695	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS18715	COG0248	Ppx GppA phosphatase
APS40_RS18720	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APS40_RS18725	COG0477	Major facilitator Superfamily
APS40_RS18730	COG0477	Major facilitator Superfamily
APS40_RS18740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APS40_RS18765	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
APS40_RS18785	COG0519	Catalyzes the synthesis of GMP from XMP
APS40_RS18785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APS40_RS18815	COG1160	GTP binding
APS40_RS18820	COG0667	Aldo Keto reductase
APS40_RS18825	COG2207	Transcriptional regulator
APS40_RS18830	COG1253	flavin adenine dinucleotide binding
APS40_RS18835	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS18840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APS40_RS18860	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS18895	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APS40_RS18900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APS40_RS18935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APS40_RS18940	COG0360	Binds together with S18 to 16S ribosomal RNA
APS40_RS18955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APS40_RS18960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APS40_RS18975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APS40_RS18980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APS40_RS18985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APS40_RS18990	COG1561	YicC-like family, N-terminal region
APS40_RS18995	COG0194	GDP metabolic process
APS40_RS19010	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APS40_RS19025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APS40_RS19045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APS40_RS19065	COG0488	(ABC) transporter
APS40_RS19080	COG0105	UTP biosynthetic process
APS40_RS19090	COG1942	4-Oxalocrotonate Tautomerase
APS40_RS19095	COG1942	4-Oxalocrotonate Tautomerase
APS40_RS19100	COG2066	Belongs to the glutaminase family
APS40_RS19110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APS40_RS19155	COG0243	molybdopterin cofactor binding
APS40_RS19160	COG0730	response to heat
APS40_RS19170	COG0625	glutathione transferase activity
APS40_RS19185	COG0702	epimerase
APS40_RS19195	COG0662	Cupin 2, conserved barrel domain protein
APS40_RS19195	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
APS40_RS19205	COG0431	NADPH-dependent FMN reductase
APS40_RS19210	COG1959	2 iron, 2 sulfur cluster binding
APS40_RS19225	COG4172	Belongs to the ABC transporter superfamily
APS40_RS19240	COG0747	negative chemotaxis
APS40_RS19275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APS40_RS19305	COG0438	transferase activity, transferring glycosyl groups
APS40_RS19310	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
APS40_RS19325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APS40_RS19330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APS40_RS19335	COG0483	inositol monophosphate 1-phosphatase activity
APS40_RS19345	COG3842	ATPase activity
APS40_RS19365	COG0673	inositol 2-dehydrogenase activity
APS40_RS19380	COG3842	ATPase activity
APS40_RS19385	COG0395	ABC-type sugar transport system, permease component
APS40_RS19420	COG0747	negative chemotaxis
APS40_RS19425	COG0601	transmembrane transport
APS40_RS19430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS19435	COG4172	Belongs to the ABC transporter superfamily
APS40_RS19440	COG1486	melibiose metabolic process
APS40_RS19450	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
APS40_RS19500	COG0673	inositol 2-dehydrogenase activity
APS40_RS19505	COG2188	Transcriptional regulator
APS40_RS19510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APS40_RS19515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APS40_RS19525	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS19545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APS40_RS19545	COG3743	rRNA binding
APS40_RS19555	COG0741	lytic transglycosylase activity
APS40_RS19565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APS40_RS19570	COG1073	alpha beta
APS40_RS19575	COG1573	uracil-dna glycosylase
APS40_RS19585	COG1758	RNA polymerase activity
APS40_RS19595	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APS40_RS19600	COG0736	holo-[acyl-carrier-protein] synthase activity
APS40_RS19605	COG0681	Belongs to the peptidase S26 family
APS40_RS19610	COG0571	ribonuclease III activity
APS40_RS19615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APS40_RS19620	COG1381	Involved in DNA repair and RecF pathway recombination
APS40_RS19650	COG0113	porphobilinogen synthase activity
APS40_RS19660	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
APS40_RS19675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APS40_RS19690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APS40_RS19695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APS40_RS19700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APS40_RS19705	COG2814	Major facilitator Superfamily
APS40_RS19725	COG0416	fatty acid biosynthetic process
APS40_RS19730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APS40_RS19735	COG0776	regulation of translation
APS40_RS19765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APS40_RS19775	COG0768	penicillin binding
APS40_RS19805	COG0489	protein tyrosine kinase activity
APS40_RS19805	COG3206	protein involved in exopolysaccharide biosynthesis
APS40_RS19825	COG1612	heme a metabolic process
APS40_RS19845	COG0438	transferase activity, transferring glycosyl groups
APS40_RS19850	COG0640	Transcriptional regulator
APS40_RS19860	COG0436	Aminotransferase
APS40_RS19875	COG1494	fructose-1,6-bisphosphatase
APS40_RS19890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APS40_RS19895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APS40_RS19920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APS40_RS19925	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APS40_RS19930	COG1120	ATPase activity
APS40_RS19950	COG0640	Transcriptional regulator
APS40_RS19965	COG0673	inositol 2-dehydrogenase activity
APS40_RS19970	COG0667	Aldo Keto reductase
APS40_RS19975	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS20040	COG1272	protein, Hemolysin III
APS40_RS20045	COG0640	Transcriptional regulator
APS40_RS20060	COG1132	(ABC) transporter
APS40_RS20080	COG1609	Transcriptional regulator
APS40_RS20085	COG1653	transport
APS40_RS20090	COG1175	transmembrane transport
APS40_RS20095	COG0395	ABC-type sugar transport system, permease component
APS40_RS20100	COG3842	ATPase activity
APS40_RS20130	COG0673	inositol 2-dehydrogenase activity
APS40_RS20160	COG0626	cystathionine gamma-synthase activity
APS40_RS20165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS40_RS20170	COG4597	amino acid ABC transporter
APS40_RS20175	COG0765	amino acid transport
APS40_RS20180	COG1126	abc transporter atp-binding protein
APS40_RS20185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS40_RS20190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APS40_RS20200	COG0415	Belongs to the DNA photolyase family
APS40_RS20205	COG0175	sulfate reduction
APS40_RS20260	COG1696	Membrane protein involved in D-alanine export
APS40_RS20295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APS40_RS20305	COG0463	Glycosyl transferase, family 2
APS40_RS20310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APS40_RS20350	COG4608	Belongs to the ABC transporter superfamily
APS40_RS20355	COG0444	Belongs to the ABC transporter superfamily
APS40_RS20360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS20365	COG0601	transmembrane transport
APS40_RS20370	COG0747	negative chemotaxis
APS40_RS20405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APS40_RS20430	COG0598	Magnesium transport protein CorA
APS40_RS20435	COG0129	dihydroxy-acid dehydratase activity
APS40_RS20450	COG0708	Exodeoxyribonuclease III
APS40_RS20465	COG0316	Belongs to the HesB IscA family
APS40_RS20470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APS40_RS20475	COG0018	arginyl-trna synthetase
APS40_RS20485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APS40_RS20495	COG3842	ATPase activity
APS40_RS20500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APS40_RS20505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APS40_RS20520	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APS40_RS20550	COG1862	Preprotein translocase
APS40_RS20560	COG3737	Protein of unknown function (DUF498/DUF598)
APS40_RS20575	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
APS40_RS20585	COG0625	glutathione transferase activity
APS40_RS20600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APS40_RS20605	COG0629	single-stranded DNA binding
APS40_RS20625	COG2203	Gaf domain
APS40_RS20625	COG3706	GGDEF domain
APS40_RS20625	COG4251	negative regulation of phosphorylation
APS40_RS20625	COG5001	Diguanylate cyclase
APS40_RS20640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APS40_RS20645	COG1280	lysine exporter protein (LysE YggA)
APS40_RS20650	COG1280	lysine exporter protein (LysE YggA)
APS40_RS20660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APS40_RS20680	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APS40_RS20690	COG0343	queuine tRNA-ribosyltransferase activity
APS40_RS20695	COG0166	Belongs to the GPI family
APS40_RS20705	COG0024	Methionine aminopeptidase
APS40_RS20745	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS20795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APS40_RS20800	COG0028	Belongs to the TPP enzyme family
APS40_RS20815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APS40_RS20820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APS40_RS20845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APS40_RS20870	COG1253	flavin adenine dinucleotide binding
APS40_RS20970	COG0582	viral genome integration into host DNA
APS40_RS20990	COG0596	Alpha beta hydrolase
APS40_RS21000	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
APS40_RS21005	COG1984	allophanate hydrolase subunit 2
APS40_RS21010	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
APS40_RS21015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APS40_RS21025	COG2239	Acts as a magnesium transporter
APS40_RS21030	COG0625	glutathione transferase activity
APS40_RS21045	COG1192	Involved in chromosome partitioning
APS40_RS21055	COG1686	Belongs to the peptidase S11 family
APS40_RS21070	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS21075	COG0659	secondary active sulfate transmembrane transporter activity
APS40_RS21090	COG0537	adenosine 5'-monophosphoramidase activity
APS40_RS21115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APS40_RS21125	COG0784	Response regulator, receiver
APS40_RS21135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APS40_RS21145	COG0557	exoribonuclease II activity
APS40_RS21150	COG1754	DNA topoisomerase type I activity
APS40_RS21150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APS40_RS21155	COG0758	DNA mediated transformation
APS40_RS21160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APS40_RS21170	COG0540	Belongs to the ATCase OTCase family
APS40_RS21175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APS40_RS21195	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APS40_RS21205	COG0154	amidase activity
APS40_RS21215	COG3811	Belongs to the UPF0386 family
APS40_RS21230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APS40_RS21275	COG0456	acetyltransferase
APS40_RS21275	COG0454	-acetyltransferase
APS40_RS21280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APS40_RS21285	COG3265	gluconokinase activity
APS40_RS21290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APS40_RS21295	COG0628	permease
APS40_RS21300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APS40_RS21305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APS40_RS21310	COG0248	Ppx GppA phosphatase
APS40_RS21315	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APS40_RS21320	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APS40_RS21325	COG2200	EAL domain
APS40_RS21330	COG0281	malic enzyme
APS40_RS21330	COG0280	phosphate acetyltransferase
APS40_RS21345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APS40_RS21365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APS40_RS21370	COG3416	Protein conserved in bacteria
APS40_RS21375	COG3932	Exopolysaccharide synthesis, ExoD
APS40_RS21380	COG3773	Cell wall hydrolase
APS40_RS21420	COG0747	negative chemotaxis
APS40_RS21430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS21450	COG2267	carboxylic ester hydrolase activity
APS40_RS21460	COG3191	aminopeptidase activity
APS40_RS21485	COG1671	Belongs to the UPF0178 family
APS40_RS21500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APS40_RS21505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APS40_RS21510	COG0601	transmembrane transport
APS40_RS21520	COG4166	transmembrane transport
APS40_RS21525	COG4166	transmembrane transport
APS40_RS21565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APS40_RS21570	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APS40_RS21605	COG3920	Histidine kinase
APS40_RS21615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APS40_RS21620	COG0784	Response regulator, receiver
APS40_RS21620	COG2198	Histidine kinase
APS40_RS21620	COG2205	protein histidine kinase activity
APS40_RS21640	COG0668	transmembrane transport
APS40_RS21645	COG4989	oxidoreductase activity
APS40_RS21650	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APS40_RS21675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APS40_RS21710	COG0640	Transcriptional regulator
APS40_RS21725	COG4221	oxidoreductase activity
APS40_RS21735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APS40_RS21750	COG0511	ligase activity, forming carbon-carbon bonds
APS40_RS21765	COG0436	Aminotransferase
APS40_RS21780	COG2378	regulation of single-species biofilm formation
APS40_RS21785	COG1530	ribonuclease E activity
APS40_RS21800	COG0242	peptide deformylase activity
APS40_RS21820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APS40_RS21835	COG1653	transport
APS40_RS21840	COG1175	transmembrane transport
APS40_RS21845	COG0395	ABC-type sugar transport system, permease component
APS40_RS21855	COG1609	Transcriptional regulator
APS40_RS21865	COG4948	Mandelate Racemase Muconate Lactonizing
APS40_RS21870	COG0583	DNA-binding transcription factor activity
APS40_RS21895	COG2204	response regulator
APS40_RS21910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APS40_RS21915	COG0081	regulation of translation
APS40_RS21925	COG0222	ribosome binding
APS40_RS21930	COG0085	RNA polymerase activity
APS40_RS21935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APS40_RS21950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APS40_RS21955	COG0049	tRNA binding
APS40_RS21960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APS40_RS21965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APS40_RS21970	COG0051	transcription antitermination factor activity, RNA binding
APS40_RS21975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APS40_RS21980	COG0088	Forms part of the polypeptide exit tunnel
APS40_RS21985	COG0089	rRNA binding
APS40_RS21990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APS40_RS21995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APS40_RS22000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APS40_RS22015	COG0255	Belongs to the universal ribosomal protein uL29 family
APS40_RS22020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APS40_RS22025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APS40_RS22030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APS40_RS22035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APS40_RS22040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APS40_RS22050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APS40_RS22055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APS40_RS22060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APS40_RS22070	COG0200	Binds to the 23S rRNA
APS40_RS22080	COG0563	adenylate kinase activity
APS40_RS22085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APS40_RS22090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APS40_RS22095	COG0202	RNA polymerase activity
APS40_RS22100	COG0203	ribosomal protein L17
APS40_RS22105	COG3320	Male sterility
APS40_RS22105	COG1022	Amp-dependent synthetase and ligase
APS40_RS22110	COG0277	FAD linked oxidase domain protein
APS40_RS22135	COG0148	phosphopyruvate hydratase activity
APS40_RS22150	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APS40_RS22155	COG0508	dehydrogenase complex catalyzes the overall conversion of
APS40_RS22155	COG0022	dehydrogenase e1 component
APS40_RS22165	COG0508	dehydrogenase complex catalyzes the overall conversion of
APS40_RS22185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APS40_RS22200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APS40_RS22220	COG1058	Belongs to the CinA family
APS40_RS22220	COG1546	Belongs to the CinA family
APS40_RS22225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APS40_RS22225	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APS40_RS22230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APS40_RS22235	COG3852	Histidine kinase
APS40_RS22240	COG2204	response regulator
APS40_RS22245	COG5000	phosphorelay sensor kinase activity
APS40_RS22250	COG2204	response regulator
APS40_RS22255	COG1923	regulation of RNA biosynthetic process
APS40_RS22260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APS40_RS22265	COG3956	TIGRFAM MazG family protein
APS40_RS22285	COG0084	hydrolase, TatD family'
APS40_RS22290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APS40_RS22295	COG0470	DNA polymerase III
APS40_RS22300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APS40_RS22305	COG1686	Belongs to the peptidase S11 family
APS40_RS22340	COG0789	Transcriptional regulator
APS40_RS22355	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APS40_RS22360	COG0321	lipoyl(octanoyl) transferase activity
APS40_RS22375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APS40_RS22380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APS40_RS22390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APS40_RS22400	COG0546	phosphoglycolate phosphatase activity
APS40_RS22405	COG0546	phosphoglycolate phosphatase activity
APS40_RS22420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APS40_RS22425	COG2268	Band 7 protein
APS40_RS22435	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APS40_RS22450	COG0386	Belongs to the glutathione peroxidase family
APS40_RS22455	COG2771	luxR family
APS40_RS22480	COG0504	CTP synthase activity
APS40_RS22490	COG0149	triose-phosphate isomerase activity
APS40_RS22500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APS40_RS22510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APS40_RS22515	COG0134	indole-3-glycerol-phosphate synthase activity
APS40_RS22520	COG0315	cyclic pyranopterin monophosphate synthase activity
APS40_RS22525	COG0303	'Molybdopterin
APS40_RS22530	COG4208	sulfate ABC transporter
APS40_RS22580	COG2223	nitrite transmembrane transporter activity
APS40_RS22585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APS40_RS22590	COG3734	2-keto-3-deoxy-galactonokinase
APS40_RS22595	COG0800	Aldolase
APS40_RS22600	COG3386	PFAM SMP-30 Gluconolaconase
APS40_RS22620	COG0372	Belongs to the citrate synthase family
APS40_RS22625	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APS40_RS22635	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APS40_RS22640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APS40_RS22645	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APS40_RS22655	COG0750	zinc metalloprotease
APS40_RS22660	COG4589	Belongs to the CDS family
APS40_RS22665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APS40_RS22670	COG0233	cytoplasmic translational termination
APS40_RS22675	COG0528	UMP kinase activity
APS40_RS22680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APS40_RS22685	COG0052	Belongs to the universal ribosomal protein uS2 family
APS40_RS22705	COG1136	(ABC) transporter
APS40_RS22745	COG1007	ATP synthesis coupled electron transport
APS40_RS22770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APS40_RS22775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APS40_RS22785	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
APS40_RS22790	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APS40_RS22795	COG0649	NAD binding
APS40_RS22800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APS40_RS22810	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APS40_RS22835	COG0776	regulation of translation
APS40_RS22850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APS40_RS22855	COG0372	Belongs to the citrate synthase family
APS40_RS22860	COG0372	Belongs to the citrate synthase family
APS40_RS22880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APS40_RS22885	COG0740	serine-type endopeptidase activity
APS40_RS22915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APS40_RS22915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APS40_RS22920	COG0544	peptidyl-prolyl cis-trans isomerase activity
APS40_RS22935	COG0347	Belongs to the P(II) protein family
APS40_RS22940	COG0174	glutamine synthetase
APS40_RS22950	COG2354	Protein conserved in bacteria
APS40_RS22955	COG2826	transposase and inactivated derivatives, IS30 family
APS40_RS22960	COG0596	Alpha beta hydrolase
APS40_RS22975	COG1280	lysine exporter protein (LysE YggA)
APS40_RS22985	COG0488	(ABC) transporter
APS40_RS23000	COG0187	DNA topoisomerase II activity
APS40_RS23005	COG0513	Belongs to the DEAD box helicase family
APS40_RS23015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APS40_RS23020	COG0316	Belongs to the HesB IscA family
APS40_RS23025	COG2151	metal-sulfur cluster biosynthetic enzyme
APS40_RS23030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APS40_RS23035	COG0719	Fe-S assembly protein
APS40_RS23040	COG0396	ATPase activity
APS40_RS23055	COG0662	Cupin 2, conserved barrel domain protein
APS40_RS23060	COG0719	Fe-S assembly protein
APS40_RS23070	COG2945	thiolester hydrolase activity
APS40_RS23075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APS40_RS23090	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APS40_RS23095	COG0739	heme binding
APS40_RS23100	COG0022	dehydrogenase e1 component
APS40_RS23115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APS40_RS23140	COG3795	YCII-related domain
APS40_RS23145	COG3795	YCII-related domain
APS40_RS23150	COG4941	Belongs to the sigma-70 factor family
APS40_RS23170	COG0662	Cupin 2, conserved barrel domain protein
APS40_RS23175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APS40_RS23185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APS40_RS23195	COG0302	gtp cyclohydrolase
APS40_RS23200	COG2207	Transcriptional regulator
APS40_RS23205	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APS40_RS23210	COG2900	Belongs to the SlyX family
APS40_RS23275	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APS40_RS23280	COG1028	Short-chain dehydrogenase reductase Sdr
APS40_RS23285	COG3265	gluconokinase activity
APS40_RS23295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APS40_RS23320	COG3237	CsbD-like
APS40_RS23370	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APS40_RS23375	COG1546	Belongs to the CinA family
APS40_RS23375	COG1058	Belongs to the CinA family
APS40_RS23380	COG0024	Methionine aminopeptidase
APS40_RS23385	COG2003	Belongs to the UPF0758 family
APS40_RS23390	COG0785	Cytochrome C biogenesis protein
APS40_RS23405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APS40_RS23430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APS40_RS23435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APS40_RS23445	COG0047	phosphoribosylformylglycinamidine synthase activity
APS40_RS23465	COG2954	triphosphatase activity
APS40_RS23470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APS40_RS23475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APS40_RS23485	COG2852	Protein conserved in bacteria
APS40_RS23495	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APS40_RS23520	COG2814	Major facilitator Superfamily
APS40_RS23530	COG0483	inositol monophosphate 1-phosphatase activity
APS40_RS23535	COG0037	tRNA processing
APS40_RS23540	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
APS40_RS23555	COG0318	PFAM AMP-dependent synthetase and ligase
APS40_RS23565	COG2814	Major facilitator Superfamily
APS40_RS23585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APS40_RS23605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APS40_RS23610	COG1846	Transcriptional regulator
APS40_RS23615	COG0538	isocitrate dehydrogenase activity
APS40_RS23620	COG1442	glycosyl transferase family 8
APS40_RS23640	COG0697	spore germination
APS40_RS23645	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APS40_RS23650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APS40_RS23665	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
APS40_RS23670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APS40_RS23695	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APS40_RS23700	COG1684	flagellar biosynthetic protein fliR
APS40_RS23705	COG1987	bacterial-type flagellum assembly
APS40_RS23710	COG1677	Flagellar hook-basal body complex protein FliE
APS40_RS23715	COG1558	bacterial-type flagellum-dependent cell motility
APS40_RS23720	COG1815	bacterial-type flagellum-dependent cell motility
APS40_RS23730	COG1338	Plays a role in the flagellum-specific transport system
APS40_RS23755	COG1580	Controls the rotational direction of flagella during chemotaxis
APS40_RS23760	COG4786	Flagellar basal body rod
APS40_RS23765	COG4786	Flagellar basal body rod
APS40_RS23775	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
APS40_RS23780	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
APS40_RS23790	COG0488	(ABC) transporter
APS40_RS23800	COG4214	carbohydrate transport
APS40_RS23830	COG0596	Alpha beta hydrolase
APS40_RS23870	COG1706	bacterial-type flagellum-dependent cell motility
APS40_RS23885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APS40_RS23890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APS40_RS23895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APS40_RS23900	COG5443	negative regulation of bacterial-type flagellum assembly
APS40_RS23940	COG4208	sulfate ABC transporter
APS40_RS23960	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
APS40_RS23980	COG3106	COG3106 Predicted ATPase
APS40_RS24005	COG0697	spore germination
APS40_RS24010	COG1733	regulation of RNA biosynthetic process
APS40_RS24015	COG0431	NADPH-dependent FMN reductase
APS40_RS24025	COG0633	Ferredoxin
APS40_RS24030	COG0492	ferredoxin-NADP+ reductase activity
APS40_RS24035	COG0175	sulfate reduction
APS40_RS24040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APS40_RS24065	COG0633	Ferredoxin
APS40_RS24085	COG2814	Major facilitator Superfamily
APS40_RS24090	COG0438	transferase activity, transferring glycosyl groups
APS40_RS24110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APS40_RS24120	COG0861	Integral membrane protein TerC family
APS40_RS24135	COG0668	transmembrane transport
APS40_RS24140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APS40_RS24145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APS40_RS24190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APS40_RS24215	COG0667	Aldo Keto reductase
APS40_RS24220	COG0384	phenazine biosynthesis protein PhzF
APS40_RS24225	COG4702	Belongs to the UPF0303 family
APS40_RS24245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APS40_RS24250	COG1309	transcriptional regulator
APS40_RS24255	COG0667	Aldo Keto reductase
APS40_RS24280	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APS40_RS24285	COG0395	ABC-type sugar transport system, permease component
APS40_RS24290	COG3458	cephalosporin-C deacetylase activity
APS40_RS24295	COG1609	Transcriptional regulator
APS40_RS24300	COG3250	beta-galactosidase activity