locus-tag	class	description
XM25_RS00025	COG0730	response to heat
XM25_RS00045	COG1970	mechanosensitive ion channel activity
XM25_RS00050	COG4566	intracellular signal transduction
XM25_RS00055	COG0156	8-amino-7-oxononanoate synthase activity
XM25_RS00060	COG0840	transmembrane signaling receptor activity
XM25_RS00065	COG1917	Cupin 2, conserved barrel domain protein
XM25_RS00065	COG4977	sequence-specific DNA binding
XM25_RS00070	COG1486	melibiose metabolic process
XM25_RS00075	COG0667	Aldo Keto reductase
XM25_RS00085	COG2885	chlorophyll binding
XM25_RS00105	COG1376	ErfK ybiS ycfS ynhG family protein
XM25_RS00130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XM25_RS00150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XM25_RS00155	COG5328	Belongs to the UPF0262 family
XM25_RS00160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XM25_RS00165	COG0424	maF-like protein
XM25_RS00170	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
XM25_RS00200	COG3685	Protein conserved in bacteria
XM25_RS00205	COG1473	amidohydrolase
XM25_RS00215	COG3237	CsbD-like
XM25_RS00225	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS00235	COG1609	Transcriptional regulator
XM25_RS00250	COG3833	ABC-type maltose transport systems, permease component
XM25_RS00260	COG3842	ATPase activity
XM25_RS00265	COG1280	lysine exporter protein (LysE YggA)
XM25_RS00270	COG1744	ABC transporter substrate-binding protein PnrA-like
XM25_RS00275	COG3845	ABC transporter
XM25_RS00280	COG4603	Belongs to the binding-protein-dependent transport system permease family
XM25_RS00285	COG1079	Belongs to the binding-protein-dependent transport system permease family
XM25_RS00315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XM25_RS00320	COG2084	Dehydrogenase
XM25_RS00325	COG2207	Transcriptional regulator
XM25_RS00330	COG0747	negative chemotaxis
XM25_RS00335	COG0601	transmembrane transport
XM25_RS00340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS00345	COG4172	Belongs to the ABC transporter superfamily
XM25_RS00350	COG1486	melibiose metabolic process
XM25_RS00360	COG4977	sequence-specific DNA binding
XM25_RS00380	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XM25_RS00415	COG0366	Alpha amylase catalytic
XM25_RS00425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XM25_RS00430	COG0679	Auxin Efflux Carrier
XM25_RS00440	COG1473	amidohydrolase
XM25_RS00445	COG2086	electron transfer activity
XM25_RS00450	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
XM25_RS00460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XM25_RS00465	COG0489	protein tyrosine kinase activity
XM25_RS00470	COG2723	6-phospho-beta-galactosidase activity
XM25_RS00475	COG2226	methyltransferase
XM25_RS00480	COG1653	transport
XM25_RS00485	COG1175	transmembrane transport
XM25_RS00490	COG0395	ABC-type sugar transport system, permease component
XM25_RS00495	COG1609	Transcriptional regulator
XM25_RS00500	COG0366	Alpha amylase catalytic
XM25_RS00515	COG4172	Belongs to the ABC transporter superfamily
XM25_RS00530	COG0747	negative chemotaxis
XM25_RS00535	COG1178	ABC-type Fe3 transport system permease component
XM25_RS00540	COG1840	ABC-type Fe3 transport system, periplasmic component
XM25_RS00775	COG3750	Belongs to the UPF0335 family
XM25_RS00780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XM25_RS00845	COG1388	LysM domain
XM25_RS00845	COG1376	ErfK ybiS ycfS ynhG family protein
XM25_RS00850	COG2818	Glycosylase
XM25_RS00865	COG0124	histidyl-tRNA synthetase
XM25_RS00870	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
XM25_RS00875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XM25_RS00910	COG1598	PFAM Uncharacterised protein family UPF0150
XM25_RS00915	COG0459	protein refolding
XM25_RS00920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
XM25_RS00935	COG2204	response regulator
XM25_RS00955	COG2267	carboxylic ester hydrolase activity
XM25_RS00960	COG0742	ribosomal rna small subunit methyltransferase
XM25_RS00975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XM25_RS00980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XM25_RS00985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XM25_RS00990	COG0590	tRNA wobble adenosine to inosine editing
XM25_RS00995	COG1752	Esterase of the alpha-beta hydrolase superfamily
XM25_RS01000	COG0151	Belongs to the GarS family
XM25_RS01005	COG1570	exodeoxyribonuclease VII activity
XM25_RS01045	COG0785	Cytochrome C biogenesis protein
XM25_RS01055	COG3185	4-Hydroxyphenylpyruvate dioxygenase
XM25_RS01055	COG1082	Xylose isomerase domain protein TIM barrel
XM25_RS01060	COG1309	transcriptional regulator
XM25_RS01065	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XM25_RS01075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XM25_RS01085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
XM25_RS01090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XM25_RS01100	COG1116	anion transmembrane transporter activity
XM25_RS01105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XM25_RS01125	COG0196	riboflavin kinase activity
XM25_RS01130	COG0446	pyridine nucleotide-disulphide oxidoreductase
XM25_RS01140	COG3453	Protein conserved in bacteria
XM25_RS01140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XM25_RS01155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XM25_RS01160	COG1120	ATPase activity
XM25_RS01185	COG3842	ATPase activity
XM25_RS01205	COG1011	Hydrolase
XM25_RS01210	COG0483	inositol monophosphate 1-phosphatase activity
XM25_RS01220	COG1283	sodium-dependent phosphate transmembrane transporter activity
XM25_RS01230	COG1609	Transcriptional regulator
XM25_RS01235	COG2308	Evidence 4 Homologs of previously reported genes of
XM25_RS01245	COG1305	Transglutaminase-like
XM25_RS01255	COG2249	NAD(P)H dehydrogenase (quinone) activity
XM25_RS01265	COG0402	S-adenosylhomocysteine deaminase activity
XM25_RS01270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XM25_RS01310	COG0446	pyridine nucleotide-disulphide oxidoreductase
XM25_RS01340	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XM25_RS01345	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XM25_RS01355	COG0667	Aldo Keto reductase
XM25_RS01360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XM25_RS01390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XM25_RS01395	COG0109	protoheme IX farnesyltransferase activity
XM25_RS01405	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XM25_RS01430	COG0612	Peptidase, M16
XM25_RS01445	COG1678	Uncharacterized ACR, COG1678
XM25_RS01455	COG0678	peroxiredoxin activity
XM25_RS01465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XM25_RS01470	COG0509	glycine decarboxylation via glycine cleavage system
XM25_RS01475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XM25_RS01480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XM25_RS01505	COG0356	it plays a direct role in the translocation of protons across the membrane
XM25_RS01515	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XM25_RS01535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XM25_RS01540	COG1196	nuclear chromosome segregation
XM25_RS01570	COG1573	uracil-dna glycosylase
XM25_RS01585	COG0521	Mo-molybdopterin cofactor biosynthetic process
XM25_RS01590	COG0142	geranyltranstransferase activity
XM25_RS01595	COG2813	Specifically methylates the guanine in position
XM25_RS01610	COG0752	glycyl-tRNA synthetase alpha subunit
XM25_RS01625	COG1704	LemA family
XM25_RS01640	COG0751	glycine-tRNA ligase activity
XM25_RS01645	COG0328	RNA-DNA hybrid ribonuclease activity
XM25_RS01655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XM25_RS01660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XM25_RS01660	COG0574	Belongs to the PEP-utilizing enzyme family
XM25_RS01675	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
XM25_RS01680	COG0354	folic acid binding
XM25_RS01685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XM25_RS01710	COG0277	FAD linked oxidase domain protein
XM25_RS01715	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XM25_RS01720	COG0406	alpha-ribazole phosphatase activity
XM25_RS01725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XM25_RS01735	COG1722	exodeoxyribonuclease VII activity
XM25_RS01740	COG0123	including yeast histone deacetylase and acetoin utilization protein
XM25_RS01745	COG0009	L-threonylcarbamoyladenylate synthase
XM25_RS01765	COG0259	pyridoxamine-phosphate oxidase activity
XM25_RS01770	COG0484	heat shock protein binding
XM25_RS01790	COG1172	Belongs to the binding-protein-dependent transport system permease family
XM25_RS01795	COG1129	ABC transporter
XM25_RS01835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XM25_RS01840	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
XM25_RS01845	COG0747	negative chemotaxis
XM25_RS01855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS01890	COG3118	belongs to the thioredoxin family
XM25_RS01905	COG1091	dTDP-4-dehydrorhamnose reductase activity
XM25_RS01930	COG0438	transferase activity, transferring glycosyl groups
XM25_RS01950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XM25_RS01960	COG2373	Large extracellular alpha-helical protein
XM25_RS01965	COG4953	penicillin-binding protein 1C
XM25_RS02000	COG0640	Transcriptional regulator
XM25_RS02020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XM25_RS02020	COG3453	Protein conserved in bacteria
XM25_RS02040	COG5002	protein histidine kinase activity
XM25_RS02055	COG4166	transmembrane transport
XM25_RS02065	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS02070	COG2186	Transcriptional regulator
XM25_RS02075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XM25_RS02075	COG0473	3-isopropylmalate dehydrogenase activity
XM25_RS02080	COG1414	Transcriptional regulator
XM25_RS02085	COG1461	Dihydroxyacetone kinase
XM25_RS02090	COG2376	Dihydroxyacetone kinase
XM25_RS02095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XM25_RS02120	COG0747	negative chemotaxis
XM25_RS02125	COG0601	transmembrane transport
XM25_RS02130	COG0444	Belongs to the ABC transporter superfamily
XM25_RS02140	COG2188	Transcriptional regulator
XM25_RS02145	COG1363	Peptidase, m42
XM25_RS02150	COG1846	Transcriptional regulator
XM25_RS02160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XM25_RS02165	COG1917	Cupin 2, conserved barrel domain protein
XM25_RS02170	COG5285	phytanoyl-CoA dioxygenase
XM25_RS02175	COG0527	aspartate kinase activity
XM25_RS02180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XM25_RS02185	COG0765	amino acid transport
XM25_RS02190	COG0765	amino acid transport
XM25_RS02195	COG1126	abc transporter atp-binding protein
XM25_RS02205	COG0583	DNA-binding transcription factor activity
XM25_RS02210	COG2226	methyltransferase
XM25_RS02225	COG0583	DNA-binding transcription factor activity
XM25_RS02240	COG0673	inositol 2-dehydrogenase activity
XM25_RS02250	COG0444	Belongs to the ABC transporter superfamily
XM25_RS02270	COG0601	transmembrane transport
XM25_RS02275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS02280	COG0405	Gamma-glutamyltransferase
XM25_RS02285	COG3842	ATPase activity
XM25_RS02290	COG0395	ABC-type sugar transport system, permease component
XM25_RS02305	COG3976	FMN-binding domain protein
XM25_RS02305	COG1053	succinate dehydrogenase
XM25_RS02310	COG1609	Transcriptional regulator
XM25_RS02325	COG0673	inositol 2-dehydrogenase activity
XM25_RS02330	COG2186	Transcriptional regulator
XM25_RS02335	COG0747	negative chemotaxis
XM25_RS02350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XM25_RS02355	COG0444	Belongs to the ABC transporter superfamily
XM25_RS02365	COG1940	carbohydrate kinase activity
XM25_RS02365	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
XM25_RS02370	COG1136	(ABC) transporter
XM25_RS02395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XM25_RS02410	COG1396	sequence-specific DNA binding
XM25_RS02420	COG1063	alcohol dehydrogenase
XM25_RS02425	COG0673	inositol 2-dehydrogenase activity
XM25_RS02430	COG1802	Transcriptional regulator
XM25_RS02440	COG1760	l-serine dehydratase
XM25_RS02465	COG1175	transmembrane transport
XM25_RS02470	COG0395	ABC-type sugar transport system, permease component
XM25_RS02475	COG3842	ATPase activity
XM25_RS02480	COG0584	glycerophosphoryl diester phosphodiesterase
XM25_RS02485	COG1349	DNA-binding transcription factor activity
XM25_RS02495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XM25_RS02520	COG0433	COG0433 Predicted ATPase
XM25_RS02530	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XM25_RS02545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XM25_RS02555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XM25_RS02560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XM25_RS02560	COG2111	Na H antiporter
XM25_RS02565	COG2111	Na H antiporter
XM25_RS02570	COG1006	Multisubunit Na H antiporter MnhC subunit
XM25_RS02575	COG0651	ATP synthesis coupled electron transport
XM25_RS02580	COG1863	multisubunit Na H antiporter MnhE subunit
XM25_RS02585	COG2212	antiporter activity
XM25_RS02590	COG1320	monovalent cation:proton antiporter activity
XM25_RS02595	COG4957	zinc ion binding
XM25_RS02610	COG2166	iron-sulfur cluster assembly
XM25_RS02620	COG2205	protein histidine kinase activity
XM25_RS02635	COG0596	Alpha beta hydrolase
XM25_RS02635	COG0508	dehydrogenase complex catalyzes the overall conversion of
XM25_RS02640	COG2226	methyltransferase
XM25_RS02690	COG4695	Portal protein
XM25_RS02730	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
XM25_RS02815	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XM25_RS02820	COG1138	Cytochrome C-type biogenesis protein
XM25_RS02825	COG3088	subunit of a heme lyase
XM25_RS02835	COG0745	RESPONSE REGULATOR receiver
XM25_RS02840	COG2205	protein histidine kinase activity
XM25_RS02845	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XM25_RS02855	COG1136	(ABC) transporter
XM25_RS02865	COG2205	protein histidine kinase activity
XM25_RS02865	COG2202	Pas domain
XM25_RS02870	COG0308	aminopeptidase N
XM25_RS02875	COG1132	(ABC) transporter
XM25_RS02880	COG1132	(ABC) transporter
XM25_RS02885	COG1132	(ABC) transporter
XM25_RS02900	COG3250	beta-galactosidase activity
XM25_RS02905	COG0697	spore germination
XM25_RS02915	COG2271	Major facilitator Superfamily
XM25_RS02920	COG1309	transcriptional regulator
XM25_RS02945	COG1233	COG1233 Phytoene dehydrogenase and related
XM25_RS02950	COG2814	Major facilitator Superfamily
XM25_RS02955	COG1846	Transcriptional regulator
XM25_RS02960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XM25_RS02975	COG0625	glutathione transferase activity
XM25_RS02980	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
XM25_RS02985	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XM25_RS02990	COG2202	Pas domain
XM25_RS02990	COG2205	protein histidine kinase activity
XM25_RS03000	COG1522	sequence-specific DNA binding
XM25_RS03005	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XM25_RS03010	COG1376	ErfK ybiS ycfS ynhG family protein
XM25_RS03015	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XM25_RS03030	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XM25_RS03035	COG0784	Response regulator, receiver
XM25_RS03050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XM25_RS03065	COG0215	cysteine-tRNA ligase activity
XM25_RS03085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XM25_RS03100	COG5265	(ABC) transporter
XM25_RS03135	COG1609	Transcriptional regulator
XM25_RS03145	COG3842	ATPase activity
XM25_RS03155	COG1175	transmembrane transport
XM25_RS03160	COG0395	ABC-type sugar transport system, permease component
XM25_RS03165	COG2186	Transcriptional regulator
XM25_RS03175	COG0535	radical SAM domain protein
XM25_RS03180	COG0535	radical SAM domain protein
XM25_RS03185	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XM25_RS03200	COG0583	DNA-binding transcription factor activity
XM25_RS03205	COG0583	DNA-binding transcription factor activity
XM25_RS03220	COG0126	phosphoglycerate kinase activity
XM25_RS03225	COG0191	fructose-bisphosphate aldolase activity
XM25_RS03250	COG0546	phosphoglycolate phosphatase activity
XM25_RS03260	COG1228	amidohydrolase
XM25_RS03265	COG4608	Belongs to the ABC transporter superfamily
XM25_RS03270	COG0444	Belongs to the ABC transporter superfamily
XM25_RS03280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS03285	COG0601	transmembrane transport
XM25_RS03305	COG0667	Aldo Keto reductase
XM25_RS03310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
XM25_RS03320	COG0789	Transcriptional regulator
XM25_RS03330	COG0738	Major facilitator superfamily
XM25_RS03350	COG0395	ABC-type sugar transport system, permease component
XM25_RS03365	COG1737	Transcriptional regulator
XM25_RS03395	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XM25_RS03400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XM25_RS03405	COG0346	lactoylglutathione lyase activity
XM25_RS03410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XM25_RS03410	COG2111	Na H antiporter
XM25_RS03415	COG1006	Multisubunit Na H antiporter MnhC subunit
XM25_RS03420	COG0651	ATP synthesis coupled electron transport
XM25_RS03425	COG1863	multisubunit Na H antiporter MnhE subunit
XM25_RS03430	COG2212	antiporter activity
XM25_RS03435	COG1320	monovalent cation:proton antiporter activity
XM25_RS03440	COG0586	Pfam SNARE associated Golgi protein
XM25_RS03460	COG2207	Transcriptional regulator
XM25_RS03465	COG1120	ATPase activity
XM25_RS03495	COG1012	belongs to the aldehyde dehydrogenase family
XM25_RS03510	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS03515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XM25_RS03520	COG1012	belongs to the aldehyde dehydrogenase family
XM25_RS03530	COG5441	Belongs to the UPF0261 family
XM25_RS03555	COG3842	ATPase activity
XM25_RS03590	COG0523	cobalamin synthesis protein
XM25_RS03595	COG0402	S-adenosylhomocysteine deaminase activity
XM25_RS03605	COG3273	potassium ion transport
XM25_RS03605	COG0471	metal ion transport
XM25_RS03615	COG3971	2-oxopent-4-enoate hydratase activity
XM25_RS03650	COG1846	Transcriptional regulator
XM25_RS03660	COG0531	amino acid
XM25_RS03670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
XM25_RS03700	COG1177	transmembrane transport
XM25_RS03705	COG1176	ABC-type spermidine putrescine transport system, permease component I
XM25_RS03710	COG3842	ATPase activity
XM25_RS03715	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XM25_RS03750	COG1609	Transcriptional regulator
XM25_RS03755	COG1609	Transcriptional regulator
XM25_RS03760	COG0363	glucosamine-6-phosphate deaminase activity
XM25_RS03765	COG4821	SIS domain
XM25_RS03785	COG1175	transmembrane transport
XM25_RS03790	COG0395	ABC-type sugar transport system, permease component
XM25_RS03800	COG3842	ATPase activity
XM25_RS03805	COG0246	Mannitol dehydrogenase
XM25_RS03810	COG1312	Catalyzes the dehydration of D-mannonate
XM25_RS03845	COG3842	ATPase activity
XM25_RS03855	COG0395	ABC-type sugar transport system, permease component
XM25_RS03860	COG1175	transmembrane transport
XM25_RS03865	COG1653	transport
XM25_RS03870	COG1609	Transcriptional regulator
XM25_RS03875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XM25_RS03880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XM25_RS03885	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XM25_RS03890	COG2205	protein histidine kinase activity
XM25_RS03895	COG0745	RESPONSE REGULATOR receiver
XM25_RS03915	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
XM25_RS03925	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
XM25_RS03930	COG0395	ABC-type sugar transport system, permease component
XM25_RS03935	COG1175	transmembrane transport
XM25_RS03940	COG1653	transport
XM25_RS03950	COG0747	negative chemotaxis
XM25_RS03960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS03965	COG4172	Belongs to the ABC transporter superfamily
XM25_RS03970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XM25_RS03975	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XM25_RS03980	COG0454	-acetyltransferase
XM25_RS03990	COG1215	transferase activity, transferring glycosyl groups
XM25_RS04010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XM25_RS04025	COG0747	negative chemotaxis
XM25_RS04030	COG0601	transmembrane transport
XM25_RS04060	COG1175	transmembrane transport
XM25_RS04065	COG0395	ABC-type sugar transport system, permease component
XM25_RS04070	COG0402	S-adenosylhomocysteine deaminase activity
XM25_RS04075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XM25_RS04090	COG0402	S-adenosylhomocysteine deaminase activity
XM25_RS04110	COG4266	Belongs to the allantoicase family
XM25_RS04130	COG0601	transmembrane transport
XM25_RS04135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS04165	COG1175	transmembrane transport
XM25_RS04175	COG0395	ABC-type sugar transport system, permease component
XM25_RS04190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XM25_RS04195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XM25_RS04200	COG4948	Mandelate Racemase Muconate Lactonizing
XM25_RS04205	COG3842	ATPase activity
XM25_RS04210	COG0395	ABC-type sugar transport system, permease component
XM25_RS04230	COG4948	Mandelate Racemase Muconate Lactonizing
XM25_RS04235	COG4948	Mandelate Racemase Muconate Lactonizing
XM25_RS04255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XM25_RS04280	COG1079	Belongs to the binding-protein-dependent transport system permease family
XM25_RS04290	COG3845	ABC transporter
XM25_RS04295	COG1744	ABC transporter substrate-binding protein PnrA-like
XM25_RS04310	COG0747	negative chemotaxis
XM25_RS04315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS04320	COG0601	transmembrane transport
XM25_RS04335	COG1737	Transcriptional regulator
XM25_RS04345	COG0747	negative chemotaxis
XM25_RS04350	COG0601	transmembrane transport
XM25_RS04355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS04360	COG0444	Belongs to the ABC transporter superfamily
XM25_RS04365	COG4608	Belongs to the ABC transporter superfamily
XM25_RS04380	COG1132	(ABC) transporter
XM25_RS04385	COG1132	(ABC) transporter
XM25_RS04445	COG2814	Major facilitator Superfamily
XM25_RS04450	COG0583	DNA-binding transcription factor activity
XM25_RS04455	COG0667	Aldo Keto reductase
XM25_RS04470	COG3842	ATPase activity
XM25_RS04475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XM25_RS04480	COG3540	Alkaline phosphatase
XM25_RS04485	COG0584	glycerophosphoryl diester phosphodiesterase
XM25_RS04490	COG0395	ABC-type sugar transport system, permease component
XM25_RS04495	COG1175	transmembrane transport
XM25_RS04500	COG1653	transport
XM25_RS04505	COG0783	Belongs to the Dps family
XM25_RS04510	COG2140	Oxalate decarboxylase
XM25_RS04520	COG0745	RESPONSE REGULATOR receiver
XM25_RS04525	COG4566	intracellular signal transduction
XM25_RS04530	COG4191	Histidine kinase
XM25_RS04535	COG2205	protein histidine kinase activity
XM25_RS04550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XM25_RS04560	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS04585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XM25_RS04595	COG0583	DNA-binding transcription factor activity
XM25_RS04605	COG0514	ATP-dependent DNA helicase (RecQ)
XM25_RS04630	COG1715	Restriction endonuclease
XM25_RS04640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XM25_RS04660	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XM25_RS04695	COG0477	Major facilitator Superfamily
XM25_RS04700	COG0477	Major facilitator Superfamily
XM25_RS04720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XM25_RS04720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XM25_RS04725	COG1490	D-aminoacyl-tRNA deacylase activity
XM25_RS04730	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
XM25_RS04740	COG0519	Catalyzes the synthesis of GMP from XMP
XM25_RS04740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XM25_RS04785	COG1253	flavin adenine dinucleotide binding
XM25_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS04795	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
XM25_RS04820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XM25_RS04825	COG0305	Participates in initiation and elongation during chromosome replication
XM25_RS04835	COG2855	membrane
XM25_RS04855	COG1846	Transcriptional regulator
XM25_RS04860	COG0583	DNA-binding transcription factor activity
XM25_RS04875	COG0798	PFAM Bile acid sodium symporter
XM25_RS04880	COG1393	Belongs to the ArsC family
XM25_RS04890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XM25_RS04895	COG0360	Binds together with S18 to 16S ribosomal RNA
XM25_RS04905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XM25_RS04915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XM25_RS04920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XM25_RS04925	COG2207	Transcriptional regulator
XM25_RS04930	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS04935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XM25_RS04940	COG1561	YicC-like family, N-terminal region
XM25_RS04945	COG0194	GDP metabolic process
XM25_RS04960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XM25_RS04970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XM25_RS04990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XM25_RS05020	COG0488	(ABC) transporter
XM25_RS05030	COG0105	UTP biosynthetic process
XM25_RS05035	COG0513	Belongs to the DEAD box helicase family
XM25_RS05040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XM25_RS05065	COG0243	molybdopterin cofactor binding
XM25_RS05070	COG0730	response to heat
XM25_RS05080	COG0625	glutathione transferase activity
XM25_RS05090	COG1228	amidohydrolase
XM25_RS05115	COG0444	Belongs to the ABC transporter superfamily
XM25_RS05120	COG0601	transmembrane transport
XM25_RS05125	COG0747	negative chemotaxis
XM25_RS05130	COG0667	Aldo Keto reductase
XM25_RS05135	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS05140	COG1063	alcohol dehydrogenase
XM25_RS05155	COG1349	DNA-binding transcription factor activity
XM25_RS05170	COG3842	ATPase activity
XM25_RS05200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XM25_RS05235	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS05245	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS05265	COG0601	transmembrane transport
XM25_RS05275	COG0444	Belongs to the ABC transporter superfamily
XM25_RS05280	COG4608	Belongs to the ABC transporter superfamily
XM25_RS05300	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XM25_RS05310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XM25_RS05315	COG4988	ABC transporter
XM25_RS05325	COG1294	oxidase, subunit
XM25_RS05360	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XM25_RS05360	COG0662	Cupin 2, conserved barrel domain protein
XM25_RS05380	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
XM25_RS05385	COG2188	Transcriptional regulator
XM25_RS05390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XM25_RS05395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XM25_RS05400	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS05410	COG2885	chlorophyll binding
XM25_RS05410	COG3047	cAMP biosynthetic process
XM25_RS05415	COG3743	rRNA binding
XM25_RS05415	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XM25_RS05425	COG0741	lytic transglycosylase activity
XM25_RS05435	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XM25_RS05440	COG1573	uracil-dna glycosylase
XM25_RS05450	COG1758	RNA polymerase activity
XM25_RS05460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XM25_RS05465	COG0736	holo-[acyl-carrier-protein] synthase activity
XM25_RS05470	COG0681	Belongs to the peptidase S26 family
XM25_RS05475	COG0571	ribonuclease III activity
XM25_RS05480	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XM25_RS05490	COG1381	Involved in DNA repair and RecF pathway recombination
XM25_RS05495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
XM25_RS05510	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XM25_RS05530	COG1609	Transcriptional regulator
XM25_RS05535	COG0113	porphobilinogen synthase activity
XM25_RS05575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XM25_RS05585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XM25_RS05605	COG0416	fatty acid biosynthetic process
XM25_RS05610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XM25_RS05615	COG0776	regulation of translation
XM25_RS05635	COG0477	Major facilitator Superfamily
XM25_RS05655	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS05660	COG3254	rhamnose metabolic process
XM25_RS05685	COG1596	polysaccharide export
XM25_RS05705	COG1612	heme a metabolic process
XM25_RS05710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XM25_RS05720	COG5658	integral membrane protein
XM25_RS05725	COG1823	symporter activity
XM25_RS05730	COG1819	glycosyl
XM25_RS05735	COG0436	Aminotransferase
XM25_RS05745	COG1494	fructose-1,6-bisphosphatase
XM25_RS05760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XM25_RS05765	COG4221	oxidoreductase activity
XM25_RS05775	COG0129	dihydroxy-acid dehydratase activity
XM25_RS05795	COG2197	response regulator
XM25_RS05805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XM25_RS05810	COG0579	oxidoreductase
XM25_RS05850	COG2207	Transcriptional regulator
XM25_RS05855	COG0300	oxidoreductase activity
XM25_RS05860	COG0412	Dienelactone hydrolase
XM25_RS05880	COG0346	lactoylglutathione lyase activity
XM25_RS05885	COG1278	Cold shock
XM25_RS05895	COG1272	protein, Hemolysin III
XM25_RS05915	COG0052	Belongs to the universal ribosomal protein uS2 family
XM25_RS05920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XM25_RS05925	COG0528	UMP kinase activity
XM25_RS05930	COG0233	cytoplasmic translational termination
XM25_RS05935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XM25_RS05940	COG0575	Belongs to the CDS family
XM25_RS05945	COG0750	zinc metalloprotease
XM25_RS05955	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XM25_RS05960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XM25_RS05965	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XM25_RS05970	COG3494	Protein of unknown function (DUF1009)
XM25_RS05975	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XM25_RS05980	COG0372	Belongs to the citrate synthase family
XM25_RS06000	COG3386	PFAM SMP-30 Gluconolaconase
XM25_RS06005	COG0800	Aldolase
XM25_RS06010	COG3734	2-keto-3-deoxy-galactonokinase
XM25_RS06015	COG0129	dihydroxy-acid dehydratase activity
XM25_RS06020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XM25_RS06030	COG1289	transmembrane transporter activity
XM25_RS06045	COG0303	'Molybdopterin
XM25_RS06050	COG0315	cyclic pyranopterin monophosphate synthase activity
XM25_RS06055	COG0134	indole-3-glycerol-phosphate synthase activity
XM25_RS06060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XM25_RS06070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XM25_RS06080	COG0149	triose-phosphate isomerase activity
XM25_RS06085	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XM25_RS06090	COG0504	CTP synthase activity
XM25_RS06100	COG2202	Pas domain
XM25_RS06100	COG3920	Histidine kinase
XM25_RS06105	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XM25_RS06110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XM25_RS06115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XM25_RS06125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XM25_RS06140	COG1253	flavin adenine dinucleotide binding
XM25_RS06165	COG1984	allophanate hydrolase subunit 2
XM25_RS06170	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
XM25_RS06175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XM25_RS06215	COG1172	Belongs to the binding-protein-dependent transport system permease family
XM25_RS06225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XM25_RS06230	COG1940	carbohydrate kinase activity
XM25_RS06235	COG1215	transferase activity, transferring glycosyl groups
XM25_RS06260	COG3842	ATPase activity
XM25_RS06290	COG4176	ABC-type proline glycine betaine transport system permease component
XM25_RS06295	COG0517	IMP dehydrogenase activity
XM25_RS06295	COG4175	Glycine betaine
XM25_RS06300	COG1942	4-Oxalocrotonate Tautomerase
XM25_RS06310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XM25_RS06315	COG2072	flavoprotein involved in K transport
XM25_RS06320	COG1737	Transcriptional regulator
XM25_RS06325	COG1116	anion transmembrane transporter activity
XM25_RS06330	COG2011	ABC-type metal ion transport system permease component
XM25_RS06340	COG0673	inositol 2-dehydrogenase activity
XM25_RS06345	COG3964	amidohydrolase
XM25_RS06355	COG5002	protein histidine kinase activity
XM25_RS06365	COG0745	RESPONSE REGULATOR receiver
XM25_RS06390	COG1129	ABC transporter
XM25_RS06400	COG0395	ABC-type sugar transport system, permease component
XM25_RS06405	COG1175	transmembrane transport
XM25_RS06415	COG3250	beta-galactosidase activity
XM25_RS06420	COG1609	Transcriptional regulator
XM25_RS06425	COG1522	sequence-specific DNA binding
XM25_RS06455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
XM25_RS06460	COG4948	Mandelate Racemase Muconate Lactonizing
XM25_RS06485	COG1137	ATPase activity
XM25_RS06495	COG1012	belongs to the aldehyde dehydrogenase family
XM25_RS06515	COG0183	Belongs to the thiolase family
XM25_RS06520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XM25_RS06525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XM25_RS06530	COG3485	protocatechuate 3,4-dioxygenase
XM25_RS06535	COG3485	protocatechuate 3,4-dioxygenase
XM25_RS06540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XM25_RS06550	COG0583	DNA-binding transcription factor activity
XM25_RS06555	COG3842	ATPase activity
XM25_RS06575	COG0683	leucine binding
XM25_RS06605	COG0084	hydrolase, TatD family'
XM25_RS06620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XM25_RS06625	COG1686	Belongs to the peptidase S11 family
XM25_RS06640	COG3956	TIGRFAM MazG family protein
XM25_RS06650	COG1923	regulation of RNA biosynthetic process
XM25_RS06655	COG2204	response regulator
XM25_RS06660	COG5000	phosphorelay sensor kinase activity
XM25_RS06665	COG2204	response regulator
XM25_RS06670	COG3852	Histidine kinase
XM25_RS06675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XM25_RS06680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XM25_RS06680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XM25_RS06685	COG1058	Belongs to the CinA family
XM25_RS06685	COG1546	Belongs to the CinA family
XM25_RS06695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XM25_RS06705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XM25_RS06715	COG0508	dehydrogenase complex catalyzes the overall conversion of
XM25_RS06720	COG0022	dehydrogenase e1 component
XM25_RS06720	COG0508	dehydrogenase complex catalyzes the overall conversion of
XM25_RS06725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XM25_RS06745	COG0148	phosphopyruvate hydratase activity
XM25_RS06760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XM25_RS06800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XM25_RS06815	COG0024	Methionine aminopeptidase
XM25_RS06820	COG0166	Belongs to the GPI family
XM25_RS06825	COG0343	queuine tRNA-ribosyltransferase activity
XM25_RS06835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XM25_RS06850	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XM25_RS06875	COG1136	(ABC) transporter
XM25_RS06885	COG0442	prolyl-tRNA aminoacylation
XM25_RS06890	COG2264	protein methyltransferase activity
XM25_RS06910	COG1007	ATP synthesis coupled electron transport
XM25_RS06925	COG0713	ATP synthesis coupled electron transport
XM25_RS06935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XM25_RS06940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XM25_RS06960	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XM25_RS06965	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XM25_RS06975	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XM25_RS06985	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XM25_RS07010	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS07015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XM25_RS07020	COG1879	ABC-type sugar transport system periplasmic component
XM25_RS07035	COG1132	(ABC) transporter
XM25_RS07040	COG1132	(ABC) transporter
XM25_RS07075	COG0776	regulation of translation
XM25_RS07090	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS07100	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
XM25_RS07105	COG0372	Belongs to the citrate synthase family
XM25_RS07120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XM25_RS07125	COG0740	serine-type endopeptidase activity
XM25_RS07135	COG2124	cytochrome p450
XM25_RS07150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XM25_RS07150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XM25_RS07165	COG0347	Belongs to the P(II) protein family
XM25_RS07170	COG0174	glutamine synthetase
XM25_RS07175	COG0488	(ABC) transporter
XM25_RS07180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
XM25_RS07185	COG1733	regulation of RNA biosynthetic process
XM25_RS07190	COG0702	epimerase
XM25_RS07210	COG0629	single-stranded DNA binding
XM25_RS07215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XM25_RS07220	COG0625	glutathione transferase activity
XM25_RS07225	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
XM25_RS07260	COG1862	Preprotein translocase
XM25_RS07275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XM25_RS07280	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XM25_RS07285	COG0805	protein transport
XM25_RS07290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XM25_RS07295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XM25_RS07300	COG3842	ATPase activity
XM25_RS07305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XM25_RS07310	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XM25_RS07320	COG0018	arginyl-trna synthetase
XM25_RS07325	COG0232	Belongs to the dGTPase family. Type 2 subfamily
XM25_RS07330	COG0316	Belongs to the HesB IscA family
XM25_RS07355	COG0525	valine-tRNA ligase activity
XM25_RS07370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XM25_RS07385	COG3842	ATPase activity
XM25_RS07390	COG0395	ABC-type sugar transport system, permease component
XM25_RS07430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XM25_RS07440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XM25_RS07445	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
XM25_RS07465	COG1999	signal sequence binding
XM25_RS07500	COG0625	glutathione transferase activity
XM25_RS07505	COG3135	benzoate transporter
XM25_RS07510	COG0746	molybdenum cofactor guanylyltransferase activity
XM25_RS07540	COG2274	protein secretion by the type I secretion system
XM25_RS07550	COG1271	oxidase subunit
XM25_RS07555	COG1294	oxidase, subunit
XM25_RS07570	COG0175	sulfate reduction
XM25_RS07575	COG0415	Belongs to the DNA photolyase family
XM25_RS07580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XM25_RS07585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XM25_RS07590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XM25_RS07595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XM25_RS07600	COG1126	abc transporter atp-binding protein
XM25_RS07605	COG0765	amino acid transport
XM25_RS07610	COG4597	amino acid ABC transporter
XM25_RS07615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XM25_RS07620	COG0626	cystathionine gamma-synthase activity
XM25_RS07625	COG0671	phosphoesterase, PA-phosphatase related
XM25_RS07645	COG0673	inositol 2-dehydrogenase activity
XM25_RS07665	COG3842	ATPase activity
XM25_RS07670	COG0395	ABC-type sugar transport system, permease component
XM25_RS07675	COG1175	transmembrane transport
XM25_RS07680	COG1653	transport
XM25_RS07685	COG1609	Transcriptional regulator
XM25_RS07705	COG2003	Belongs to the UPF0758 family
XM25_RS07925	COG0629	single-stranded DNA binding
XM25_RS08080	COG0187	DNA topoisomerase II activity
XM25_RS08085	COG0513	Belongs to the DEAD box helicase family
XM25_RS08090	COG3706	GGDEF domain
XM25_RS08095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XM25_RS08100	COG0316	Belongs to the HesB IscA family
XM25_RS08110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XM25_RS08115	COG0719	Fe-S assembly protein
XM25_RS08120	COG0396	ATPase activity
XM25_RS08125	COG0719	Fe-S assembly protein
XM25_RS08135	COG2945	thiolester hydrolase activity
XM25_RS08140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XM25_RS08150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XM25_RS08155	COG0739	heme binding
XM25_RS08165	COG0242	peptide deformylase activity
XM25_RS08170	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XM25_RS08180	COG1530	ribonuclease E activity
XM25_RS08195	COG0436	Aminotransferase
XM25_RS08210	COG0511	ligase activity, forming carbon-carbon bonds
XM25_RS08220	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XM25_RS08255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XM25_RS08275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
XM25_RS08280	COG1780	Probably involved in ribonucleotide reductase function
XM25_RS08300	COG0640	Transcriptional regulator
XM25_RS08315	COG2911	Protein conserved in bacteria
XM25_RS08315	COG3210	domain, Protein
XM25_RS08340	COG0395	ABC-type sugar transport system, permease component
XM25_RS08345	COG1175	transmembrane transport
XM25_RS08355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XM25_RS08360	COG0183	Belongs to the thiolase family
XM25_RS08390	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS08415	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XM25_RS08420	COG1653	transport
XM25_RS08440	COG1653	transport
XM25_RS08450	COG0395	ABC-type sugar transport system, permease component
XM25_RS08460	COG3842	ATPase activity
XM25_RS08465	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
XM25_RS08490	COG0356	it plays a direct role in the translocation of protons across the membrane
XM25_RS08515	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
XM25_RS08520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XM25_RS08535	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS08550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XM25_RS08555	COG0574	Belongs to the PEP-utilizing enzyme family
XM25_RS08555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XM25_RS08560	COG0837	glucose binding
XM25_RS08565	COG0517	IMP dehydrogenase activity
XM25_RS08570	COG1105	Belongs to the carbohydrate kinase PfkB family
XM25_RS08575	COG1830	Aldolase
XM25_RS08635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XM25_RS08650	COG1596	polysaccharide export
XM25_RS08655	COG2273	Hydrolase Family 16
XM25_RS08680	COG1215	transferase activity, transferring glycosyl groups
XM25_RS08700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XM25_RS08705	COG3206	protein involved in exopolysaccharide biosynthesis
XM25_RS08705	COG0489	protein tyrosine kinase activity
XM25_RS08710	COG1215	transferase activity, transferring glycosyl groups
XM25_RS08715	COG1215	transferase activity, transferring glycosyl groups
XM25_RS08720	COG0438	transferase activity, transferring glycosyl groups
XM25_RS08730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XM25_RS08730	COG0473	3-isopropylmalate dehydrogenase activity
XM25_RS08735	COG0747	negative chemotaxis
XM25_RS08745	COG4174	ABC transporter (Permease)
XM25_RS08750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS08755	COG0444	Belongs to the ABC transporter superfamily
XM25_RS08760	COG4608	Belongs to the ABC transporter superfamily
XM25_RS08765	COG1414	Transcriptional regulator
XM25_RS08770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XM25_RS08775	COG3971	2-oxopent-4-enoate hydratase activity
XM25_RS08790	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XM25_RS08805	COG0659	secondary active sulfate transmembrane transporter activity
XM25_RS08810	COG3300	MHYT domain
XM25_RS08810	COG5001	Diguanylate cyclase
XM25_RS08820	COG0395	ABC-type sugar transport system, permease component
XM25_RS08825	COG1175	transmembrane transport
XM25_RS08835	COG2188	Transcriptional regulator
XM25_RS08845	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
XM25_RS08860	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
XM25_RS08875	COG4608	Belongs to the ABC transporter superfamily
XM25_RS08880	COG0444	Belongs to the ABC transporter superfamily
XM25_RS08885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS08890	COG0601	transmembrane transport
XM25_RS08895	COG0747	negative chemotaxis
XM25_RS08930	COG0246	Mannitol dehydrogenase
XM25_RS08950	COG1176	ABC-type spermidine putrescine transport system, permease component I
XM25_RS08960	COG3842	ATPase activity
XM25_RS08970	COG0483	inositol monophosphate 1-phosphatase activity
XM25_RS08975	COG0671	phosphoesterase, PA-phosphatase related
XM25_RS08990	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
XM25_RS08995	COG3416	Protein conserved in bacteria
XM25_RS09005	COG1216	Glycosyl transferase, family 2
XM25_RS09005	COG1442	glycosyl transferase family 8
XM25_RS09010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XM25_RS09015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XM25_RS09025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
XM25_RS09030	COG0280	phosphate acetyltransferase
XM25_RS09030	COG0281	malic enzyme
XM25_RS09035	COG2200	EAL domain
XM25_RS09040	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XM25_RS09045	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
XM25_RS09050	COG0248	Ppx GppA phosphatase
XM25_RS09055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XM25_RS09065	COG0628	permease
XM25_RS09070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XM25_RS09075	COG3265	gluconokinase activity
XM25_RS09080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XM25_RS09085	COG0456	acetyltransferase
XM25_RS09100	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
XM25_RS09120	COG3811	Belongs to the UPF0386 family
XM25_RS09135	COG0154	amidase activity
XM25_RS09145	COG0454	-acetyltransferase
XM25_RS09150	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
XM25_RS09160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XM25_RS09170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XM25_RS09175	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
XM25_RS09180	COG0758	DNA mediated transformation
XM25_RS09190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XM25_RS09190	COG1754	DNA topoisomerase type I activity
XM25_RS09195	COG0557	exoribonuclease II activity
XM25_RS09205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XM25_RS09225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XM25_RS09250	COG0537	adenosine 5'-monophosphoramidase activity
XM25_RS09280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XM25_RS09285	COG1686	Belongs to the peptidase S11 family
XM25_RS09295	COG3706	GGDEF domain
XM25_RS09300	COG1192	Involved in chromosome partitioning
XM25_RS09310	COG0625	glutathione transferase activity
XM25_RS09315	COG2239	Acts as a magnesium transporter
XM25_RS09335	COG0386	Belongs to the glutathione peroxidase family
XM25_RS09360	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
XM25_RS09365	COG0321	lipoyl(octanoyl) transferase activity
XM25_RS09375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XM25_RS09380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XM25_RS09390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XM25_RS09400	COG0546	phosphoglycolate phosphatase activity
XM25_RS09410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XM25_RS09425	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XM25_RS09430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XM25_RS09445	COG0203	ribosomal protein L17
XM25_RS09450	COG0202	RNA polymerase activity
XM25_RS09455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XM25_RS09460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XM25_RS09465	COG0563	adenylate kinase activity
XM25_RS09470	COG0201	protein transport
XM25_RS09475	COG0200	Binds to the 23S rRNA
XM25_RS09485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XM25_RS09490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XM25_RS09495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XM25_RS09500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XM25_RS09505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XM25_RS09510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XM25_RS09515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XM25_RS09520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XM25_RS09525	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XM25_RS09530	COG0255	Belongs to the universal ribosomal protein uL29 family
XM25_RS09535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XM25_RS09540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XM25_RS09545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XM25_RS09550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XM25_RS09555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XM25_RS09560	COG0089	rRNA binding
XM25_RS09565	COG0088	Forms part of the polypeptide exit tunnel
XM25_RS09570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XM25_RS09575	COG0051	transcription antitermination factor activity, RNA binding
XM25_RS09580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XM25_RS09585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XM25_RS09590	COG0049	tRNA binding
XM25_RS09595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XM25_RS09605	COG4122	O-methyltransferase activity
XM25_RS09610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XM25_RS09615	COG0085	RNA polymerase activity
XM25_RS09620	COG0222	ribosome binding
XM25_RS09625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XM25_RS09630	COG0081	regulation of translation
XM25_RS09635	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XM25_RS09645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XM25_RS09650	COG0589	response to stress
XM25_RS09685	COG2261	transglycosylase associated protein
XM25_RS09720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XM25_RS09730	COG1671	Belongs to the UPF0178 family
XM25_RS09740	COG1129	ABC transporter
XM25_RS09745	COG4214	carbohydrate transport
XM25_RS09750	COG4213	ABC transporter substrate-binding protein
XM25_RS09755	COG1940	carbohydrate kinase activity
XM25_RS09755	COG1846	Transcriptional regulator
XM25_RS09760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XM25_RS09800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XM25_RS09825	COG0745	RESPONSE REGULATOR receiver
XM25_RS09830	COG2205	protein histidine kinase activity
XM25_RS09850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XM25_RS09855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XM25_RS09865	COG0302	gtp cyclohydrolase
XM25_RS09870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XM25_RS09920	COG2267	carboxylic ester hydrolase activity
XM25_RS09940	COG0456	acetyltransferase
XM25_RS09940	COG0454	-acetyltransferase
XM25_RS09950	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS09955	COG3265	gluconokinase activity
XM25_RS09985	COG2814	Major facilitator Superfamily
XM25_RS09990	COG0583	DNA-binding transcription factor activity
XM25_RS10010	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
XM25_RS10015	COG1058	Belongs to the CinA family
XM25_RS10015	COG1546	Belongs to the CinA family
XM25_RS10020	COG0024	Methionine aminopeptidase
XM25_RS10025	COG2003	Belongs to the UPF0758 family
XM25_RS10035	COG0785	Cytochrome C biogenesis protein
XM25_RS10045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
XM25_RS10065	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XM25_RS10070	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XM25_RS10080	COG0047	phosphoribosylformylglycinamidine synthase activity
XM25_RS10090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XM25_RS10125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XM25_RS10135	COG2814	Major facilitator Superfamily
XM25_RS10140	COG0483	inositol monophosphate 1-phosphatase activity
XM25_RS10145	COG0037	tRNA processing
XM25_RS10150	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
XM25_RS10155	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XM25_RS10165	COG2814	Major facilitator Superfamily
XM25_RS10170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XM25_RS10185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XM25_RS10205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XM25_RS10215	COG0693	protein deglycase activity
XM25_RS10225	COG0538	isocitrate dehydrogenase activity
XM25_RS10235	COG4221	oxidoreductase activity
XM25_RS10260	COG0697	spore germination
XM25_RS10265	COG0697	spore germination
XM25_RS10270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XM25_RS10275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XM25_RS10285	COG1172	Belongs to the binding-protein-dependent transport system permease family
XM25_RS10290	COG1129	ABC transporter
XM25_RS10310	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XM25_RS10315	COG1684	flagellar biosynthetic protein fliR
XM25_RS10320	COG1987	bacterial-type flagellum assembly
XM25_RS10325	COG1677	Flagellar hook-basal body complex protein FliE
XM25_RS10330	COG1558	bacterial-type flagellum-dependent cell motility
XM25_RS10335	COG1815	bacterial-type flagellum-dependent cell motility
XM25_RS10340	COG3190	flagellar
XM25_RS10345	COG1338	Plays a role in the flagellum-specific transport system
XM25_RS10375	COG4786	Flagellar basal body rod
XM25_RS10380	COG4786	Flagellar basal body rod
XM25_RS10390	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XM25_RS10395	COG0625	glutathione transferase activity
XM25_RS10400	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
XM25_RS10405	COG0488	(ABC) transporter
XM25_RS10420	COG1706	bacterial-type flagellum-dependent cell motility
XM25_RS10440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XM25_RS10445	COG5443	negative regulation of bacterial-type flagellum assembly
XM25_RS10465	COG1749	Flagellar hook protein flgE
XM25_RS10475	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
XM25_RS10485	COG3106	COG3106 Predicted ATPase
XM25_RS10490	COG3768	UPF0283 membrane protein
XM25_RS10500	COG1733	regulation of RNA biosynthetic process
XM25_RS10515	COG0492	ferredoxin-NADP+ reductase activity
XM25_RS10520	COG0175	sulfate reduction
XM25_RS10525	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XM25_RS10535	COG1648	precorrin-2 dehydrogenase activity
XM25_RS10535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XM25_RS10540	COG0395	ABC-type sugar transport system, permease component
XM25_RS10545	COG0633	Ferredoxin
XM25_RS10550	COG2199	diguanylate cyclase activity
XM25_RS10595	COG0438	transferase activity, transferring glycosyl groups
XM25_RS10610	COG1472	Belongs to the glycosyl hydrolase 3 family
XM25_RS10620	COG2259	Doxx family
XM25_RS10625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XM25_RS10645	COG0861	Integral membrane protein TerC family
XM25_RS10650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XM25_RS10655	COG4174	ABC transporter (Permease)
XM25_RS10660	COG4239	(ABC) transporter, permease
XM25_RS10665	COG4172	Belongs to the ABC transporter superfamily
XM25_RS10670	COG4166	transmembrane transport
XM25_RS10680	COG0668	transmembrane transport
XM25_RS10685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XM25_RS10690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XM25_RS10695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XM25_RS10705	COG0384	phenazine biosynthesis protein PhzF
XM25_RS10710	COG4702	Belongs to the UPF0303 family
XM25_RS10725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XM25_RS10730	COG1309	transcriptional regulator
XM25_RS10740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XM25_RS10755	COG1278	Cold shock
XM25_RS10760	COG2249	NAD(P)H dehydrogenase (quinone) activity
XM25_RS10765	COG0640	Transcriptional regulator
XM25_RS10795	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XM25_RS10805	COG2814	Major facilitator Superfamily
XM25_RS10830	COG0440	acetolactate synthase activity
XM25_RS10835	COG0028	Belongs to the TPP enzyme family
XM25_RS10845	COG1280	lysine exporter protein (LysE YggA)
XM25_RS10855	COG5002	protein histidine kinase activity
XM25_RS10860	COG0745	RESPONSE REGULATOR receiver
XM25_RS10870	COG1278	Cold shock
XM25_RS10895	COG0534	Mate efflux family protein
XM25_RS10900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XM25_RS10905	COG0560	Phosphoserine phosphatase
XM25_RS10905	COG3830	Belongs to the UPF0237 family
XM25_RS10915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XM25_RS10920	COG0330	HflC and HflK could
XM25_RS10925	COG0330	HflC and HflK could
XM25_RS10935	COG0456	acetyltransferase
XM25_RS10950	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XM25_RS10980	COG0443	Heat shock 70 kDa protein
XM25_RS11005	COG2186	Transcriptional regulator
XM25_RS11020	COG2983	Belongs to the UPF0260 family
XM25_RS11070	COG2264	protein methyltransferase activity
XM25_RS11075	COG0006	proline dipeptidase activity
XM25_RS11100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XM25_RS11110	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XM25_RS11120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
XM25_RS11130	COG0849	cell division
XM25_RS11135	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XM25_RS11140	COG1181	Belongs to the D-alanine--D-alanine ligase family
XM25_RS11145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XM25_RS11150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XM25_RS11160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XM25_RS11165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XM25_RS11170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XM25_RS11200	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XM25_RS11210	COG2873	o-acetylhomoserine
XM25_RS11230	COG0640	Transcriptional regulator
XM25_RS11245	COG0753	catalase activity
XM25_RS11255	COG2962	Rard protein
XM25_RS11270	COG4106	trans-aconitate 2-methyltransferase activity
XM25_RS11275	COG0488	(ABC) transporter
XM25_RS11305	COG1522	sequence-specific DNA binding
XM25_RS11310	COG0686	Belongs to the AlaDH PNT family
XM25_RS11360	COG0411	ABC transporter
XM25_RS11370	COG0829	nickel cation binding
XM25_RS11375	COG0831	urea catabolic process
XM25_RS11380	COG0832	Belongs to the urease beta subunit family
XM25_RS11395	COG0804	urea catabolic process
XM25_RS11415	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
XM25_RS11420	COG0830	nickel cation binding
XM25_RS11430	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
XM25_RS11445	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XM25_RS11450	COG1523	belongs to the glycosyl hydrolase 13 family
XM25_RS11455	COG0033	Phosphoglucomutase
XM25_RS11460	COG0297	glycogen (starch) synthase activity
XM25_RS11465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
XM25_RS11470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XM25_RS11475	COG0058	SHG alpha-glucan phosphorylase activity
XM25_RS11480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XM25_RS11480	COG0475	glutathione-regulated potassium exporter activity
XM25_RS11490	COG1957	nucleoside hydrolase
XM25_RS11495	COG1280	lysine exporter protein (LysE YggA)
XM25_RS11500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XM25_RS11505	COG2094	Belongs to the DNA glycosylase MPG family
XM25_RS11530	COG2755	lipolytic protein G-D-S-L family
XM25_RS11530	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XM25_RS11535	COG3458	cephalosporin-C deacetylase activity
XM25_RS11540	COG1132	(ABC) transporter
XM25_RS11570	COG2814	Major facilitator Superfamily
XM25_RS11575	COG1609	Transcriptional regulator
XM25_RS11580	COG1129	ABC transporter
XM25_RS11585	COG1172	Belongs to the binding-protein-dependent transport system permease family
XM25_RS11590	COG1879	ABC-type sugar transport system periplasmic component
XM25_RS11615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XM25_RS11620	COG0471	metal ion transport
XM25_RS11620	COG0490	domain, Protein
XM25_RS11625	COG2195	Cleaves the N-terminal amino acid of tripeptides
XM25_RS11630	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
XM25_RS11650	COG1278	Cold shock
XM25_RS11675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XM25_RS11680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XM25_RS11700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XM25_RS11710	COG3454	Phosphonate metabolism
XM25_RS11720	COG3639	organic phosphonate transmembrane transporter activity
XM25_RS11725	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
XM25_RS11730	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
XM25_RS11740	COG4778	phosphonate C-P lyase system protein PhnL
XM25_RS11745	COG4107	phosphonate C-P lyase system protein PhnK
XM25_RS11750	COG3627	carbon phosphorus lyase activity
XM25_RS11755	COG3626	phosphonate metabolism
XM25_RS11760	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
XM25_RS11765	COG3624	Phosphonate C-P lyase system protein PhnG
XM25_RS11770	COG2188	Transcriptional regulator
XM25_RS11775	COG1012	belongs to the aldehyde dehydrogenase family
XM25_RS11795	COG0432	Pfam Uncharacterised protein family UPF0047
XM25_RS11810	COG0640	Transcriptional regulator
XM25_RS11820	COG2862	Uncharacterized protein family, UPF0114
XM25_RS11855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XM25_RS11875	COG2814	Major facilitator Superfamily
XM25_RS11885	COG0505	Belongs to the CarA family
XM25_RS11895	COG2321	neutral zinc metallopeptidase
XM25_RS11900	COG0737	Belongs to the 5'-nucleotidase family
XM25_RS11905	COG1846	Transcriptional regulator
XM25_RS11910	COG1764	response to oxidative stress
XM25_RS11915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XM25_RS11925	COG2814	Major facilitator Superfamily
XM25_RS11940	COG0656	L-ascorbic acid biosynthetic process
XM25_RS11970	COG0110	maltose O-acetyltransferase activity
XM25_RS11975	COG3706	GGDEF domain
XM25_RS11985	COG1278	Cold shock
XM25_RS11990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XM25_RS11995	COG0492	ferredoxin-NADP+ reductase activity
XM25_RS12000	COG0583	DNA-binding transcription factor activity
XM25_RS12010	COG0598	Magnesium transport protein CorA
XM25_RS12025	COG0436	Aminotransferase
XM25_RS12040	COG0516	GMP reductase activity
XM25_RS12040	COG0517	IMP dehydrogenase activity
XM25_RS12060	COG2205	protein histidine kinase activity
XM25_RS12065	COG1435	thymidine kinase activity
XM25_RS12075	COG4941	Belongs to the sigma-70 factor family
XM25_RS12130	COG0556	nucleotide-excision repair
XM25_RS12175	COG5342	invasion associated locus B
XM25_RS12185	COG0322	excinuclease ABC activity
XM25_RS12190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XM25_RS12195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XM25_RS12205	COG0314	molybdopterin synthase activity
XM25_RS12215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XM25_RS12220	COG1846	Transcriptional regulator
XM25_RS12230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XM25_RS12255	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XM25_RS12275	COG3795	YCII-related domain
XM25_RS12280	COG3795	YCII-related domain
XM25_RS12285	COG3795	YCII-related domain
XM25_RS12300	COG0193	aminoacyl-tRNA hydrolase activity
XM25_RS12305	COG0012	GTP binding
XM25_RS12350	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XM25_RS12355	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XM25_RS12355	COG2857	Cytochrome c1
XM25_RS12360	COG2857	Cytochrome c1
XM25_RS12360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XM25_RS12365	COG0723	plastoquinol--plastocyanin reductase activity
XM25_RS12370	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XM25_RS12405	COG0435	Glutathione S-transferase
XM25_RS12410	COG2814	Major facilitator Superfamily
XM25_RS12420	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XM25_RS12440	COG1365	unkown
XM25_RS12445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XM25_RS12455	COG0346	lactoylglutathione lyase activity
XM25_RS12460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
XM25_RS12460	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
XM25_RS12465	COG4770	biotin carboxylase activity
XM25_RS12470	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
XM25_RS12475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XM25_RS12480	COG0604	alcohol dehydrogenase
XM25_RS12495	COG5001	Diguanylate cyclase
XM25_RS12495	COG3300	MHYT domain
XM25_RS12510	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS12515	COG1063	alcohol dehydrogenase
XM25_RS12540	COG5001	Diguanylate cyclase
XM25_RS12540	COG3300	MHYT domain
XM25_RS12545	COG3300	MHYT domain
XM25_RS12545	COG5001	Diguanylate cyclase
XM25_RS12560	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
XM25_RS12565	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XM25_RS12570	COG0402	S-adenosylhomocysteine deaminase activity
XM25_RS12585	COG1079	Belongs to the binding-protein-dependent transport system permease family
XM25_RS12590	COG4603	Belongs to the binding-protein-dependent transport system permease family
XM25_RS12595	COG3845	ABC transporter
XM25_RS12615	COG2351	hydroxyisourate hydrolase activity
XM25_RS12625	COG0737	Belongs to the 5'-nucleotidase family
XM25_RS12640	COG0640	Transcriptional regulator
XM25_RS12655	COG4266	Belongs to the allantoicase family
XM25_RS12660	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
XM25_RS12680	COG0513	Belongs to the DEAD box helicase family
XM25_RS12685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XM25_RS12715	COG0673	inositol 2-dehydrogenase activity
XM25_RS12745	COG3693	PFAM glycoside hydrolase, family 10
XM25_RS12745	COG2382	esterase
XM25_RS12765	COG3842	ATPase activity
XM25_RS12770	COG2897	thiosulfate sulfurtransferase activity
XM25_RS12780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XM25_RS12785	COG4214	carbohydrate transport
XM25_RS12790	COG1129	ABC transporter
XM25_RS12795	COG4213	ABC transporter substrate-binding protein
XM25_RS12800	COG2188	Transcriptional regulator
XM25_RS12810	COG1012	belongs to the aldehyde dehydrogenase family
XM25_RS12815	COG1177	transmembrane transport
XM25_RS12820	COG1176	ABC-type spermidine putrescine transport system, permease component I
XM25_RS12825	COG3842	ATPase activity
XM25_RS12830	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XM25_RS12835	COG0583	DNA-binding transcription factor activity
XM25_RS12860	COG3920	Histidine kinase
XM25_RS12860	COG2202	Pas domain
XM25_RS12895	COG0784	Response regulator, receiver
XM25_RS12915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XM25_RS12920	COG4215	(ABC) transporter
XM25_RS12925	COG4160	amino acid transport
XM25_RS12935	COG5001	Diguanylate cyclase
XM25_RS12935	COG3300	MHYT domain
XM25_RS12940	COG0156	8-amino-7-oxononanoate synthase activity
XM25_RS12950	COG0784	Response regulator, receiver
XM25_RS12950	COG5002	protein histidine kinase activity
XM25_RS12960	COG2860	membrane
XM25_RS12965	COG3842	ATPase activity
XM25_RS12980	COG1653	transport
XM25_RS12985	COG1609	Transcriptional regulator
XM25_RS12990	COG2301	Belongs to the HpcH HpaI aldolase family
XM25_RS12995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
XM25_RS13005	COG1397	ADP-ribosylglycohydrolase
XM25_RS13015	COG0395	ABC-type sugar transport system, permease component
XM25_RS13020	COG4209	transmembrane transport
XM25_RS13025	COG1609	Transcriptional regulator
XM25_RS13035	COG2378	regulation of single-species biofilm formation
XM25_RS13095	COG1131	(ABC) transporter
XM25_RS13125	COG0583	DNA-binding transcription factor activity
XM25_RS13140	COG0395	ABC-type sugar transport system, permease component
XM25_RS13190	COG2188	Transcriptional regulator
XM25_RS13195	COG1940	carbohydrate kinase activity
XM25_RS13200	COG0395	ABC-type sugar transport system, permease component
XM25_RS13205	COG1175	transmembrane transport
XM25_RS13215	COG5265	(ABC) transporter
XM25_RS13235	COG1131	(ABC) transporter
XM25_RS13270	COG0387	Pfam Sodium calcium exchanger
XM25_RS13285	COG1442	glycosyl transferase family 8
XM25_RS13290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XM25_RS13300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XM25_RS13320	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS13325	COG0179	Fumarylacetoacetate (FAA) hydrolase
XM25_RS13330	COG0251	oxidation-reduction process
XM25_RS13335	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
XM25_RS13355	COG4608	Belongs to the ABC transporter superfamily
XM25_RS13360	COG0444	Belongs to the ABC transporter superfamily
XM25_RS13365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS13370	COG0601	transmembrane transport
XM25_RS13375	COG4166	transmembrane transport
XM25_RS13400	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XM25_RS13410	COG2274	protein secretion by the type I secretion system
XM25_RS13420	COG0523	cobalamin synthesis protein
XM25_RS13455	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
XM25_RS13460	COG2223	nitrite transmembrane transporter activity
XM25_RS13475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XM25_RS13480	COG3842	ATPase activity
XM25_RS13485	COG0395	ABC-type sugar transport system, permease component
XM25_RS13490	COG1175	transmembrane transport
XM25_RS13510	COG1609	Transcriptional regulator
XM25_RS13520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XM25_RS13530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
XM25_RS13550	COG4608	Belongs to the ABC transporter superfamily
XM25_RS13555	COG0444	Belongs to the ABC transporter superfamily
XM25_RS13560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS13565	COG0601	transmembrane transport
XM25_RS13575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XM25_RS13580	COG0747	negative chemotaxis
XM25_RS13585	COG0583	DNA-binding transcription factor activity
XM25_RS13595	COG0300	oxidoreductase activity
XM25_RS13600	COG4948	Mandelate Racemase Muconate Lactonizing
XM25_RS13605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XM25_RS13610	COG0395	ABC-type sugar transport system, permease component
XM25_RS13615	COG1175	transmembrane transport
XM25_RS13645	COG3734	2-keto-3-deoxy-galactonokinase
XM25_RS13670	COG0346	lactoylglutathione lyase activity
XM25_RS13675	COG3706	GGDEF domain
XM25_RS13695	COG2304	oxidoreductase activity
XM25_RS13705	COG0482	sulfurtransferase activity
XM25_RS13730	COG1766	The M ring may be actively involved in energy transduction
XM25_RS13735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
XM25_RS13745	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
XM25_RS13750	COG2204	response regulator
XM25_RS13755	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XM25_RS13760	COG2153	protein acetylation
XM25_RS13765	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
XM25_RS13805	COG1609	Transcriptional regulator
XM25_RS13810	COG0745	RESPONSE REGULATOR receiver
XM25_RS13840	COG0564	pseudouridine synthase activity
XM25_RS13845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XM25_RS13850	COG3093	addiction module antidote protein HigA
XM25_RS13875	COG1178	ABC-type Fe3 transport system permease component
XM25_RS13890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XM25_RS13905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XM25_RS13915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XM25_RS13940	COG1126	abc transporter atp-binding protein
XM25_RS13985	COG1121	(ABC) transporter
XM25_RS14010	COG1012	belongs to the aldehyde dehydrogenase family
XM25_RS14040	COG1126	abc transporter atp-binding protein
XM25_RS14065	COG1737	Transcriptional regulator
XM25_RS14095	COG0444	Belongs to the ABC transporter superfamily
XM25_RS14145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XM25_RS14155	COG0583	DNA-binding transcription factor activity
XM25_RS14175	COG3214	Protein conserved in bacteria
XM25_RS14190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XM25_RS14195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XM25_RS14200	COG0037	tRNA processing
XM25_RS14210	COG2885	chlorophyll binding
XM25_RS14215	COG0823	Involved in the tonB-independent uptake of proteins
XM25_RS14225	COG0848	biopolymer transport protein
XM25_RS14235	COG0824	Thioesterase
XM25_RS14245	COG2255	four-way junction helicase activity
XM25_RS14250	COG0632	four-way junction helicase activity
XM25_RS14255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XM25_RS14260	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
XM25_RS14275	COG1692	metallophosphoesterase
XM25_RS14280	COG0217	transcriptional regulatory protein
XM25_RS14285	COG5002	protein histidine kinase activity
XM25_RS14285	COG5001	Diguanylate cyclase
XM25_RS14285	COG3447	MASE1 domain protein
XM25_RS14315	COG0126	phosphoglycerate kinase activity
XM25_RS14320	COG3588	fructose-bisphosphate aldolase
XM25_RS14335	COG0483	inositol monophosphate 1-phosphatase activity
XM25_RS14355	COG1132	(ABC) transporter
XM25_RS14360	COG0254	rRNA binding
XM25_RS14405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
XM25_RS14410	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XM25_RS14450	COG0789	Transcriptional regulator
XM25_RS14480	COG2204	response regulator
XM25_RS14490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XM25_RS14510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS14515	COG0601	transmembrane transport
XM25_RS14520	COG4166	transmembrane transport
XM25_RS14525	COG0183	Belongs to the thiolase family
XM25_RS14530	COG1024	Enoyl-CoA hydratase
XM25_RS14530	COG1250	3-hydroxyacyl-CoA dehydrogenase
XM25_RS14535	COG1960	acyl-CoA dehydrogenase activity
XM25_RS14540	COG0318	PFAM AMP-dependent synthetase and ligase
XM25_RS14545	COG0789	Transcriptional regulator
XM25_RS14550	COG0322	excinuclease ABC activity
XM25_RS14560	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XM25_RS14560	COG1793	dna ligase
XM25_RS14575	COG0667	Aldo Keto reductase
XM25_RS14580	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XM25_RS14585	COG1643	Atp-dependent helicase
XM25_RS14600	COG2199	diguanylate cyclase activity
XM25_RS14640	COG0067	glutamate synthase
XM25_RS14640	COG0069	glutamate synthase activity
XM25_RS14640	COG0070	glutamate synthase
XM25_RS14645	COG0625	glutathione transferase activity
XM25_RS14675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XM25_RS14685	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
XM25_RS14690	COG0330	HflC and HflK could
XM25_RS14695	COG1585	Membrane protein implicated in regulation of membrane protease activity
XM25_RS14700	COG1360	Flagellar Motor Protein
XM25_RS14705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XM25_RS14715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XM25_RS14720	COG1914	H( )-stimulated, divalent metal cation uptake system
XM25_RS14730	COG0708	Exodeoxyribonuclease III
XM25_RS14745	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
XM25_RS14760	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
XM25_RS14765	COG0583	DNA-binding transcription factor activity
XM25_RS14775	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
XM25_RS14780	COG0800	Aldolase
XM25_RS14795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XM25_RS14810	COG2721	sulfolactate sulfo-lyase activity
XM25_RS14815	COG1254	Belongs to the acylphosphatase family
XM25_RS14820	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XM25_RS14840	COG1396	sequence-specific DNA binding
XM25_RS14850	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
XM25_RS14875	COG1304	FMN binding
XM25_RS14915	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XM25_RS14920	COG0179	Fumarylacetoacetate (FAA) hydrolase
XM25_RS14940	COG0251	oxidation-reduction process
XM25_RS14945	COG0586	Pfam SNARE associated Golgi protein
XM25_RS14950	COG0457	Tetratricopeptide repeat
XM25_RS14965	COG1454	alcohol dehydrogenase
XM25_RS14970	COG0400	carboxylic ester hydrolase activity
XM25_RS14975	COG0346	lactoylglutathione lyase activity
XM25_RS14980	COG2375	cellular response to nickel ion
XM25_RS14995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XM25_RS15015	COG2183	response to ionizing radiation
XM25_RS15020	COG3264	Mechanosensitive ion channel
XM25_RS15020	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
XM25_RS15025	COG3938	Belongs to the proline racemase family
XM25_RS15035	COG1609	Transcriptional regulator
XM25_RS15040	COG0747	negative chemotaxis
XM25_RS15045	COG0601	transmembrane transport
XM25_RS15050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS15060	COG4608	Belongs to the ABC transporter superfamily
XM25_RS15085	COG1802	Transcriptional regulator
XM25_RS15090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XM25_RS15100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
XM25_RS15105	COG1312	Catalyzes the dehydration of D-mannonate
XM25_RS15415	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XM25_RS15450	COG0739	heme binding
XM25_RS15455	COG0477	Major facilitator Superfamily
XM25_RS15465	COG0542	response to heat
XM25_RS15475	COG2890	protein-(glutamine-N5) methyltransferase activity
XM25_RS15480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XM25_RS15490	COG0527	aspartate kinase activity
XM25_RS15495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XM25_RS15520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XM25_RS15525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
XM25_RS15535	COG2226	methyltransferase
XM25_RS15545	COG0494	nUDIX hydrolase
XM25_RS15550	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
XM25_RS15565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XM25_RS15570	COG0653	protein targeting
XM25_RS15575	COG3034	peptidoglycan biosynthetic process
XM25_RS15580	COG0825	malonyl-CoA metabolic process
XM25_RS15585	COG4974	Belongs to the 'phage' integrase family
XM25_RS15595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XM25_RS15600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XM25_RS15630	COG2226	methyltransferase
XM25_RS15645	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XM25_RS15650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
XM25_RS15680	COG1329	Transcriptional regulator
XM25_RS15685	COG4783	chaperone-mediated protein folding
XM25_RS15705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
XM25_RS15710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
XM25_RS15715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XM25_RS15720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XM25_RS15725	COG1120	ATPase activity
XM25_RS15770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XM25_RS15775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XM25_RS15780	COG0444	Belongs to the ABC transporter superfamily
XM25_RS15785	COG4608	Belongs to the ABC transporter superfamily
XM25_RS15790	COG3395	kinase activity
XM25_RS15795	COG2186	Transcriptional regulator
XM25_RS15810	COG4166	transmembrane transport
XM25_RS15815	COG0601	transmembrane transport
XM25_RS15820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS15825	COG1454	alcohol dehydrogenase
XM25_RS15845	COG0071	Belongs to the small heat shock protein (HSP20) family
XM25_RS15850	COG1686	Belongs to the peptidase S11 family
XM25_RS15855	COG2378	regulation of single-species biofilm formation
XM25_RS15870	COG1733	regulation of RNA biosynthetic process
XM25_RS15880	COG0534	Mate efflux family protein
XM25_RS15900	COG1595	DNA-templated transcription, initiation
XM25_RS15990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XM25_RS16010	COG2096	Adenosyltransferase
XM25_RS16025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XM25_RS16030	COG0165	Argininosuccinate lyase
XM25_RS16035	COG0019	diaminopimelate decarboxylase activity
XM25_RS16040	COG1346	cytolysis
XM25_RS16060	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XM25_RS16065	COG4208	sulfate ABC transporter
XM25_RS16070	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XM25_RS16075	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XM25_RS16080	COG1959	2 iron, 2 sulfur cluster binding
XM25_RS16085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XM25_RS16085	COG4651	solute:proton antiporter activity
XM25_RS16095	COG4948	Mandelate Racemase Muconate Lactonizing
XM25_RS16100	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS16105	COG4948	Mandelate Racemase Muconate Lactonizing
XM25_RS16110	COG3842	ATPase activity
XM25_RS16115	COG0395	ABC-type sugar transport system, permease component
XM25_RS16120	COG1175	transmembrane transport
XM25_RS16140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XM25_RS16175	COG3254	rhamnose metabolic process
XM25_RS16190	COG2186	Transcriptional regulator
XM25_RS16195	COG1846	Transcriptional regulator
XM25_RS16215	COG0840	transmembrane signaling receptor activity
XM25_RS16235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
XM25_RS16240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
XM25_RS16250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XM25_RS16270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XM25_RS16275	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XM25_RS16280	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XM25_RS16290	COG0799	negative regulation of ribosome biogenesis
XM25_RS16295	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XM25_RS16300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XM25_RS16305	COG0277	FAD linked oxidase domain protein
XM25_RS16310	COG1695	Transcriptional regulator
XM25_RS16315	COG0335	large ribosomal subunit rRNA binding
XM25_RS16335	COG1999	signal sequence binding
XM25_RS16340	COG0336	Belongs to the RNA methyltransferase TrmD family
XM25_RS16345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XM25_RS16350	COG0228	four-way junction DNA binding
XM25_RS16355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XM25_RS16375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XM25_RS16380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XM25_RS16385	COG0552	protein localization to endoplasmic reticulum
XM25_RS16390	COG2917	probably involved in intracellular septation
XM25_RS16400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XM25_RS16405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XM25_RS16410	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XM25_RS16415	COG4133	protoheme IX ABC transporter activity
XM25_RS16420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
XM25_RS16445	COG0670	Belongs to the BI1 family
XM25_RS16450	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
XM25_RS16465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XM25_RS16480	COG0793	Belongs to the peptidase S41A family
XM25_RS16485	COG2861	carbohydrate metabolic process
XM25_RS16490	COG0494	nUDIX hydrolase
XM25_RS16500	COG1794	racemase activity, acting on amino acids and derivatives
XM25_RS16515	COG0745	RESPONSE REGULATOR receiver
XM25_RS16520	COG2201	protein-glutamate methylesterase activity
XM25_RS16525	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XM25_RS16530	COG0840	transmembrane signaling receptor activity
XM25_RS16535	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XM25_RS16545	COG0835	chemotaxis
XM25_RS16550	COG2198	Histidine kinase
XM25_RS16550	COG0643	Histidine kinase
XM25_RS16555	COG0745	RESPONSE REGULATOR receiver
XM25_RS16565	COG1024	Enoyl-CoA hydratase
XM25_RS16590	COG0842	Transport permease protein
XM25_RS16595	COG1131	(ABC) transporter
XM25_RS16605	COG1309	transcriptional regulator
XM25_RS16635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XM25_RS16640	COG2313	pseudouridylate synthase activity
XM25_RS16645	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XM25_RS16650	COG3842	ATPase activity
XM25_RS16655	COG1176	ABC-type spermidine putrescine transport system, permease component I
XM25_RS16660	COG1177	transmembrane transport
XM25_RS16670	COG0697	spore germination
XM25_RS16675	COG0673	inositol 2-dehydrogenase activity
XM25_RS16680	COG1879	ABC-type sugar transport system periplasmic component
XM25_RS16685	COG1172	Belongs to the binding-protein-dependent transport system permease family
XM25_RS16700	COG0673	inositol 2-dehydrogenase activity
XM25_RS16705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XM25_RS16710	COG3962	Belongs to the TPP enzyme family
XM25_RS16715	COG1082	Xylose isomerase domain protein TIM barrel
XM25_RS16720	COG3718	enzyme involved in inositol metabolism
XM25_RS16725	COG1956	GAF domain-containing protein
XM25_RS16745	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XM25_RS16750	COG1280	lysine exporter protein (LysE YggA)
XM25_RS16760	COG0137	argininosuccinate synthase activity
XM25_RS16765	COG5001	Diguanylate cyclase
XM25_RS16770	COG1217	gtp-binding protein TYPA
XM25_RS16775	COG0586	Pfam SNARE associated Golgi protein
XM25_RS16780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XM25_RS16790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XM25_RS16795	COG0287	Prephenate dehydrogenase
XM25_RS16805	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
XM25_RS16825	COG2884	Cell division ATP-binding protein ftsE
XM25_RS16835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XM25_RS16840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XM25_RS16855	COG2258	MOSC domain
XM25_RS16865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XM25_RS16880	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
XM25_RS16890	COG5001	Diguanylate cyclase
XM25_RS16890	COG3300	MHYT domain
XM25_RS16940	COG0840	transmembrane signaling receptor activity
XM25_RS16945	COG0840	transmembrane signaling receptor activity
XM25_RS16950	COG0840	transmembrane signaling receptor activity
XM25_RS16960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XM25_RS16965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XM25_RS16970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XM25_RS16975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XM25_RS16980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XM25_RS16990	COG4974	Belongs to the 'phage' integrase family
XM25_RS16995	COG0697	spore germination
XM25_RS17000	COG5001	Diguanylate cyclase
XM25_RS17000	COG3300	MHYT domain
XM25_RS17020	COG0395	ABC-type sugar transport system, permease component
XM25_RS17035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XM25_RS17075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XM25_RS17080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XM25_RS17085	COG2350	Protein conserved in bacteria
XM25_RS17105	COG0501	Belongs to the peptidase M48B family
XM25_RS17110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XM25_RS17110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XM25_RS17130	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XM25_RS17155	COG1872	DUF167
XM25_RS17160	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XM25_RS17180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XM25_RS17220	COG0587	DNA-directed DNA polymerase activity
XM25_RS17225	COG2154	pterin-4-alpha-carbinolamine dehydratase
XM25_RS17235	COG1280	lysine exporter protein (LysE YggA)
XM25_RS17245	COG0508	dehydrogenase complex catalyzes the overall conversion of
XM25_RS17255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XM25_RS17260	COG0662	Cupin 2, conserved barrel domain protein
XM25_RS17265	COG0045	succinate-CoA ligase (ADP-forming) activity
XM25_RS17270	COG0039	L-malate dehydrogenase activity
XM25_RS17275	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XM25_RS17325	COG0494	nUDIX hydrolase
XM25_RS17335	COG0288	reversible hydration of carbon dioxide
XM25_RS17355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XM25_RS17360	COG2081	HI0933 family
XM25_RS17375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XM25_RS17380	COG0473	3-isopropylmalate dehydrogenase activity
XM25_RS17385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
XM25_RS17400	COG0066	3-isopropylmalate dehydratase activity
XM25_RS17405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XM25_RS17415	COG0813	purine-nucleoside phosphorylase activity
XM25_RS17430	COG1172	Belongs to the binding-protein-dependent transport system permease family
XM25_RS17435	COG4941	Belongs to the sigma-70 factor family
XM25_RS17445	COG3795	YCII-related domain
XM25_RS17465	COG3795	YCII-related domain
XM25_RS17485	COG3118	belongs to the thioredoxin family
XM25_RS17490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
XM25_RS17495	COG2835	tetraacyldisaccharide 4'-kinase activity
XM25_RS17500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XM25_RS17505	COG0347	Belongs to the P(II) protein family
XM25_RS17510	COG0004	ammonium transporteR
XM25_RS17545	COG0745	RESPONSE REGULATOR receiver
XM25_RS17550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XM25_RS17565	COG1466	dna polymerase III delta subunit
XM25_RS17580	COG0357	Ribosomal RNA small subunit methyltransferase G
XM25_RS17590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XM25_RS17595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XM25_RS17600	COG1981	membrane
XM25_RS17605	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XM25_RS17610	COG0424	maF-like protein
XM25_RS17615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XM25_RS17620	COG0237	dephospho-CoA kinase activity
XM25_RS17625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XM25_RS17630	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XM25_RS17640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XM25_RS17655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XM25_RS17660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XM25_RS17670	COG0107	imidazoleglycerol-phosphate synthase activity
XM25_RS17675	COG0140	phosphoribosyl-ATP diphosphatase activity
XM25_RS17680	COG1072	(Pantothenic acid kinase))
XM25_RS17700	COG0284	orotidine-5'-phosphate decarboxylase activity
XM25_RS17705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XM25_RS17710	COG0588	phosphoglycerate mutase activity
XM25_RS17715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XM25_RS17735	COG1309	transcriptional regulator
XM25_RS17740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XM25_RS17745	COG0484	heat shock protein binding
XM25_RS17750	COG0657	acetylesterase activity
XM25_RS17755	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
XM25_RS17780	COG1335	isochorismatase
XM25_RS17785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XM25_RS17790	COG1420	regulation of RNA biosynthetic process
XM25_RS17795	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XM25_RS17800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XM25_RS17805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XM25_RS17820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XM25_RS17825	COG0792	nuclease activity
XM25_RS17830	COG0189	ligase activity
XM25_RS17835	COG2095	MarC family integral membrane protein
XM25_RS17845	COG0606	chelatase, subunit chli
XM25_RS17850	COG1079	Belongs to the binding-protein-dependent transport system permease family
XM25_RS17855	COG4603	Belongs to the binding-protein-dependent transport system permease family
XM25_RS17860	COG3845	ABC transporter
XM25_RS17875	COG0402	S-adenosylhomocysteine deaminase activity
XM25_RS17880	COG0295	cytidine deaminase activity
XM25_RS17890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
XM25_RS17895	COG1609	Transcriptional regulator
XM25_RS17905	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XM25_RS17920	COG0456	acetyltransferase
XM25_RS17935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XM25_RS17940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XM25_RS17945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XM25_RS17960	COG2852	Protein conserved in bacteria
XM25_RS17975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XM25_RS17980	COG1309	transcriptional regulator
XM25_RS18000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XM25_RS18005	COG1959	2 iron, 2 sulfur cluster binding
XM25_RS18015	COG0493	'glutamate synthase
XM25_RS18020	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XM25_RS18030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XM25_RS18035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XM25_RS18040	COG0815	Transfers the fatty acyl group on membrane lipoproteins
XM25_RS18050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XM25_RS18055	COG1702	phosphate starvation-inducible protein PhoH
XM25_RS18060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XM25_RS18075	COG0454	-acetyltransferase
XM25_RS18075	COG0456	acetyltransferase
XM25_RS18080	COG1214	PFAM Peptidase M22, glycoprotease
XM25_RS18085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XM25_RS18100	COG0180	Tryptophanyl-tRNA synthetase
XM25_RS18110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XM25_RS18115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XM25_RS18120	COG3507	Belongs to the glycosyl hydrolase 43 family
XM25_RS18125	COG2115	Belongs to the xylose isomerase family
XM25_RS18130	COG1070	Carbohydrate kinase
XM25_RS18145	COG0667	Aldo Keto reductase
XM25_RS18150	COG0779	Required for maturation of 30S ribosomal subunits
XM25_RS18155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XM25_RS18155	COG0195	Participates in both transcription termination and antitermination
XM25_RS18165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XM25_RS18170	COG1376	ErfK ybiS ycfS ynhG family protein
XM25_RS18175	COG0740	serine-type endopeptidase activity
XM25_RS18190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XM25_RS18195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XM25_RS18205	COG3920	Histidine kinase
XM25_RS18220	COG0640	Transcriptional regulator
XM25_RS18250	COG0477	Major facilitator Superfamily
XM25_RS18270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XM25_RS18300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XM25_RS18305	COG2226	methyltransferase
XM25_RS18310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XM25_RS18315	COG0268	Binds directly to 16S ribosomal RNA
XM25_RS18320	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XM25_RS18330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XM25_RS18345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XM25_RS18370	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XM25_RS18385	COG0738	Major facilitator superfamily
XM25_RS18395	COG0667	Aldo Keto reductase
XM25_RS18400	COG2378	regulation of single-species biofilm formation
XM25_RS18405	COG0596	Alpha beta hydrolase
XM25_RS18430	COG3655	Transcriptional regulator
XM25_RS18440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XM25_RS18450	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
XM25_RS18465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XM25_RS18475	COG1012	belongs to the aldehyde dehydrogenase family
XM25_RS18485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS18490	COG0601	transmembrane transport
XM25_RS18500	COG2186	Transcriptional regulator
XM25_RS18525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XM25_RS18530	COG2159	amidohydrolase
XM25_RS18545	COG0473	3-isopropylmalate dehydrogenase activity
XM25_RS18545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XM25_RS18550	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XM25_RS18560	COG1448	Aminotransferase
XM25_RS18590	COG0110	maltose O-acetyltransferase activity
XM25_RS18595	COG0583	DNA-binding transcription factor activity
XM25_RS18605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XM25_RS18620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
XM25_RS18630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XM25_RS18640	COG2226	methyltransferase
XM25_RS18660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XM25_RS18675	COG0367	asparagine synthase
XM25_RS18685	COG0438	transferase activity, transferring glycosyl groups
XM25_RS18690	COG0438	transferase activity, transferring glycosyl groups
XM25_RS18695	COG0367	asparagine synthase
XM25_RS18710	COG2226	methyltransferase
XM25_RS18720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XM25_RS18730	COG2226	methyltransferase
XM25_RS18735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XM25_RS18740	COG2226	methyltransferase
XM25_RS18750	COG0367	asparagine synthase
XM25_RS18770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
XM25_RS18775	COG4974	Belongs to the 'phage' integrase family
XM25_RS18780	COG1204	response to ionizing radiation
XM25_RS18845	COG1475	DNA binding
XM25_RS18880	COG5489	Protein of unknown function (DUF736)
XM25_RS18910	COG1192	Involved in chromosome partitioning
XM25_RS18955	COG4566	intracellular signal transduction
XM25_RS18960	COG4191	Histidine kinase
XM25_RS18975	COG0140	phosphoribosyl-ATP diphosphatase activity
XM25_RS18995	COG4962	Type ii secretion system protein e
XM25_RS19010	COG3451	type IV secretory pathway VirB4
XM25_RS19025	COG3846	protein secretion by the type IV secretion system
XM25_RS19040	COG2948	multi-organism process
XM25_RS19050	COG4566	intracellular signal transduction
XM25_RS19055	COG4191	Histidine kinase
XM25_RS19095	COG0745	RESPONSE REGULATOR receiver
XM25_RS19150	COG4964	Belongs to the GSP D family
XM25_RS19170	COG4964	Belongs to the GSP D family
XM25_RS19190	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XM25_RS19195	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
XM25_RS19200	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
XM25_RS19205	COG1012	belongs to the aldehyde dehydrogenase family
XM25_RS19220	COG1079	Belongs to the binding-protein-dependent transport system permease family
XM25_RS19225	COG1079	Belongs to the binding-protein-dependent transport system permease family
XM25_RS19230	COG3845	ABC transporter
XM25_RS19235	COG1744	ABC transporter substrate-binding protein PnrA-like
XM25_RS19270	COG0469	pyruvate kinase activity
XM25_RS19280	COG3750	Belongs to the UPF0335 family
XM25_RS19285	COG1309	transcriptional regulator
XM25_RS19290	COG0765	amino acid transport
XM25_RS19295	COG0765	amino acid transport
XM25_RS19305	COG1446	asparaginase
XM25_RS19310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XM25_RS19315	COG1609	Transcriptional regulator
XM25_RS19320	COG1940	carbohydrate kinase activity
XM25_RS19325	COG3142	Participates in the control of copper homeostasis
XM25_RS19335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XM25_RS19350	COG2989	Protein conserved in bacteria
XM25_RS19355	COG0129	dihydroxy-acid dehydratase activity
XM25_RS19360	COG0363	glucosamine-6-phosphate deaminase activity
XM25_RS19365	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XM25_RS19370	COG2971	BadF BadG BcrA BcrD
XM25_RS19380	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XM25_RS19385	COG1492	cobalamin metabolic process
XM25_RS19390	COG1797	cobyrinic acid a,c-diamide synthase activity
XM25_RS19400	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
XM25_RS19430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
XM25_RS19435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XM25_RS19440	COG0159	tryptophan synthase activity
XM25_RS19445	COG0133	tryptophan synthase activity
XM25_RS19450	COG0135	phosphoribosylanthranilate isomerase activity
XM25_RS19460	COG0776	regulation of translation
XM25_RS19465	COG0616	signal peptide processing
XM25_RS19475	COG0539	negative regulation of cytoplasmic translation
XM25_RS19480	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XM25_RS19525	COG3142	Participates in the control of copper homeostasis
XM25_RS19530	COG2378	regulation of single-species biofilm formation
XM25_RS19550	COG1054	Belongs to the UPF0176 family
XM25_RS19555	COG0667	Aldo Keto reductase
XM25_RS19570	COG1442	glycosyl transferase family 8
XM25_RS19580	COG0072	phenylalanine-tRNA ligase activity
XM25_RS19580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XM25_RS19595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XM25_RS19600	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XM25_RS19605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XM25_RS19610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XM25_RS19635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XM25_RS19655	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XM25_RS19665	COG1968	undecaprenyl-diphosphatase activity
XM25_RS19805	COG1598	PFAM Uncharacterised protein family UPF0150
XM25_RS20005	COG0604	alcohol dehydrogenase
XM25_RS20025	COG3795	YCII-related domain
XM25_RS20030	COG1376	ErfK ybiS ycfS ynhG family protein
XM25_RS20055	COG1137	ATPase activity
XM25_RS20060	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
XM25_RS20065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
XM25_RS20070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XM25_RS20080	COG0071	Belongs to the small heat shock protein (HSP20) family
XM25_RS20115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
XM25_RS20120	COG0745	RESPONSE REGULATOR receiver
XM25_RS20125	COG2205	protein histidine kinase activity
XM25_RS20135	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XM25_RS20135	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
XM25_RS20155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XM25_RS20160	COG4952	isomerase
XM25_RS20165	COG3347	Dehydrogenase
XM25_RS20165	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS20170	COG1349	DNA-binding transcription factor activity
XM25_RS20175	COG1879	ABC-type sugar transport system periplasmic component
XM25_RS20180	COG1129	ABC transporter
XM25_RS20185	COG1172	Belongs to the binding-protein-dependent transport system permease family
XM25_RS20205	COG1609	Transcriptional regulator
XM25_RS20215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XM25_RS20215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XM25_RS20225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XM25_RS20235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XM25_RS20240	COG3474	cytochrome
XM25_RS20245	COG1605	Chorismate mutase
XM25_RS20245	COG0077	Prephenate dehydratase
XM25_RS20250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XM25_RS20250	COG0519	Catalyzes the synthesis of GMP from XMP
XM25_RS20255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XM25_RS20260	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XM25_RS20275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XM25_RS20280	COG1846	Transcriptional regulator
XM25_RS20290	COG0477	Major facilitator Superfamily
XM25_RS20320	COG2171	N-acyltransferase activity
XM25_RS20330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XM25_RS20340	COG0101	tRNA pseudouridine synthase activity
XM25_RS20350	COG0242	peptide deformylase activity
XM25_RS20355	COG1322	Protein conserved in bacteria
XM25_RS20365	COG0667	Aldo Keto reductase
XM25_RS20370	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS20405	COG0583	DNA-binding transcription factor activity
XM25_RS20450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XM25_RS20465	COG3454	Phosphonate metabolism
XM25_RS20470	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
XM25_RS20475	COG0583	DNA-binding transcription factor activity
XM25_RS20480	COG2986	histidine ammonia-lyase
XM25_RS20485	COG1732	Glycine betaine
XM25_RS20490	COG1174	glycine betaine transport
XM25_RS20495	COG1125	glycine betaine transport
XM25_RS20500	COG1174	glycine betaine transport
XM25_RS20505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XM25_RS20520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XM25_RS20525	COG0251	oxidation-reduction process
XM25_RS20535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XM25_RS20540	COG1959	2 iron, 2 sulfur cluster binding
XM25_RS20550	COG0803	Belongs to the bacterial solute-binding protein 9 family
XM25_RS20555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XM25_RS20575	COG0523	cobalamin synthesis protein
XM25_RS20625	COG3795	YCII-related domain
XM25_RS20630	COG4941	Belongs to the sigma-70 factor family
XM25_RS20645	COG0789	Transcriptional regulator
XM25_RS20650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XM25_RS20660	COG0747	negative chemotaxis
XM25_RS20665	COG1917	Cupin 2, conserved barrel domain protein
XM25_RS20665	COG1396	sequence-specific DNA binding
XM25_RS20670	COG0601	transmembrane transport
XM25_RS20675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS20680	COG0444	Belongs to the ABC transporter superfamily
XM25_RS20685	COG4608	Belongs to the ABC transporter superfamily
XM25_RS20695	COG0729	surface antigen
XM25_RS20720	COG2197	response regulator
XM25_RS20755	COG0673	inositol 2-dehydrogenase activity
XM25_RS20770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XM25_RS20775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XM25_RS20780	COG1596	polysaccharide export
XM25_RS20805	COG1940	carbohydrate kinase activity
XM25_RS20810	COG2182	Extracellular solute-binding protein
XM25_RS20815	COG1175	transmembrane transport
XM25_RS20820	COG0395	ABC-type sugar transport system, permease component
XM25_RS20825	COG0165	Argininosuccinate lyase
XM25_RS20830	COG3842	ATPase activity
XM25_RS20845	COG3842	ATPase activity
XM25_RS20855	COG1176	ABC-type spermidine putrescine transport system, permease component I
XM25_RS20870	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XM25_RS20875	COG0583	DNA-binding transcription factor activity
XM25_RS20880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XM25_RS20895	COG3806	Anti-sigma factor
XM25_RS20900	COG1595	DNA-templated transcription, initiation
XM25_RS20915	COG0300	oxidoreductase activity
XM25_RS20925	COG1121	(ABC) transporter
XM25_RS20930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XM25_RS20935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XM25_RS20945	COG1802	Transcriptional regulator
XM25_RS20955	COG1175	transmembrane transport
XM25_RS20960	COG0395	ABC-type sugar transport system, permease component
XM25_RS20975	COG3707	response regulator
XM25_RS20980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XM25_RS20980	COG1116	anion transmembrane transporter activity
XM25_RS20985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XM25_RS20990	COG2146	nitrite reductase [NAD(P)H] activity
XM25_RS20995	COG2116	formate transmembrane transporter activity
XM25_RS21000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XM25_RS21000	COG1648	precorrin-2 dehydrogenase activity
XM25_RS21005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
XM25_RS21015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XM25_RS21020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XM25_RS21025	COG1120	ATPase activity
XM25_RS21040	COG0385	Bile acid
XM25_RS21045	COG0747	negative chemotaxis
XM25_RS21055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS21080	COG1024	Enoyl-CoA hydratase
XM25_RS21085	COG1022	Amp-dependent synthetase and ligase
XM25_RS21085	COG3320	Male sterility
XM25_RS21100	COG0477	Major facilitator Superfamily
XM25_RS21120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XM25_RS21140	COG0450	alkyl hydroperoxide reductase
XM25_RS21155	COG0765	amino acid transport
XM25_RS21165	COG3422	double-strand break repair
XM25_RS21180	COG1017	nitric oxide dioxygenase activity
XM25_RS21180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XM25_RS21205	COG3654	unkown
XM25_RS21225	COG0481	GTPase activity
XM25_RS21230	COG0583	DNA-binding transcription factor activity
XM25_RS21235	COG0667	Aldo Keto reductase
XM25_RS21245	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS21270	COG2223	nitrite transmembrane transporter activity
XM25_RS21300	COG0346	lactoylglutathione lyase activity
XM25_RS21305	COG0747	negative chemotaxis
XM25_RS21310	COG0601	transmembrane transport
XM25_RS21315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS21320	COG0444	Belongs to the ABC transporter superfamily
XM25_RS21325	COG4608	Belongs to the ABC transporter superfamily
XM25_RS21335	COG0488	(ABC) transporter
XM25_RS21345	COG2205	protein histidine kinase activity
XM25_RS21350	COG0802	atpase or kinase
XM25_RS21355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XM25_RS21365	COG1074	ATP-dependent DNA helicase activity
XM25_RS21370	COG3118	belongs to the thioredoxin family
XM25_RS21380	COG3118	belongs to the thioredoxin family
XM25_RS21385	COG0285	dihydrofolate synthase activity
XM25_RS21390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XM25_RS21395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XM25_RS21400	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
XM25_RS21410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XM25_RS21415	COG0706	membrane insertase activity
XM25_RS21420	COG0594	ribonuclease P activity
XM25_RS21425	COG0230	Belongs to the bacterial ribosomal protein bL34 family
XM25_RS21435	COG3852	Histidine kinase
XM25_RS21470	COG1120	ATPase activity
XM25_RS21475	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XM25_RS21480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XM25_RS21495	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
XM25_RS21530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS21535	COG0444	Belongs to the ABC transporter superfamily
XM25_RS21555	COG3473	Maleate cis-trans isomerase
XM25_RS21560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XM25_RS21565	COG0179	Fumarylacetoacetate (FAA) hydrolase
XM25_RS21575	COG1802	Transcriptional regulator
XM25_RS21590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
XM25_RS21595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XM25_RS21615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS21620	COG4172	Belongs to the ABC transporter superfamily
XM25_RS21625	COG0747	negative chemotaxis
XM25_RS21650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XM25_RS21680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XM25_RS21685	COG4608	Belongs to the ABC transporter superfamily
XM25_RS21695	COG4166	transmembrane transport
XM25_RS21700	COG0601	transmembrane transport
XM25_RS21705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS21715	COG2267	carboxylic ester hydrolase activity
XM25_RS21720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XM25_RS21725	COG1176	ABC-type spermidine putrescine transport system, permease component I
XM25_RS21730	COG1177	transmembrane transport
XM25_RS21735	COG3842	ATPase activity
XM25_RS21740	COG0402	S-adenosylhomocysteine deaminase activity
XM25_RS21750	COG1473	amidohydrolase
XM25_RS21755	COG1040	competence protein
XM25_RS21765	COG0745	RESPONSE REGULATOR receiver
XM25_RS21770	COG0643	Histidine kinase
XM25_RS21770	COG2198	Histidine kinase
XM25_RS21775	COG0835	chemotaxis
XM25_RS21785	COG0835	chemotaxis
XM25_RS21795	COG2201	protein-glutamate methylesterase activity
XM25_RS21840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XM25_RS21865	COG0714	Associated with various cellular activities
XM25_RS21900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XM25_RS21905	COG4166	transmembrane transport
XM25_RS21910	COG4608	Belongs to the ABC transporter superfamily
XM25_RS21915	COG0444	Belongs to the ABC transporter superfamily
XM25_RS21920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS21925	COG0601	transmembrane transport
XM25_RS21935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XM25_RS21940	COG0514	ATP-dependent DNA helicase (RecQ)
XM25_RS21945	COG1960	acyl-CoA dehydrogenase activity
XM25_RS21960	COG1082	Xylose isomerase domain protein TIM barrel
XM25_RS21965	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS21970	COG0745	RESPONSE REGULATOR receiver
XM25_RS21975	COG5002	protein histidine kinase activity
XM25_RS21990	COG1073	alpha beta
XM25_RS22000	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS22040	COG3622	Belongs to the hyi family
XM25_RS22055	COG3842	ATPase activity
XM25_RS22060	COG0673	inositol 2-dehydrogenase activity
XM25_RS22070	COG0395	ABC-type sugar transport system, permease component
XM25_RS22075	COG1175	transmembrane transport
XM25_RS22085	COG0583	DNA-binding transcription factor activity
XM25_RS22090	COG1309	transcriptional regulator
XM25_RS22095	COG0673	inositol 2-dehydrogenase activity
XM25_RS22110	COG4821	SIS domain
XM25_RS22115	COG2188	Transcriptional regulator
XM25_RS22120	COG0456	acetyltransferase
XM25_RS22125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XM25_RS22140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XM25_RS22145	COG4172	Belongs to the ABC transporter superfamily
XM25_RS22150	COG1012	belongs to the aldehyde dehydrogenase family
XM25_RS22160	COG2267	carboxylic ester hydrolase activity
XM25_RS22170	COG3191	aminopeptidase activity
XM25_RS22180	COG1063	alcohol dehydrogenase
XM25_RS22185	COG2514	catechol 2,3-dioxygenase activity
XM25_RS22200	COG2207	Transcriptional regulator
XM25_RS22235	COG1028	Short-chain dehydrogenase reductase Sdr
XM25_RS22240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XM25_RS22250	COG1012	belongs to the aldehyde dehydrogenase family
XM25_RS22255	COG0174	glutamine synthetase
XM25_RS22260	COG0531	amino acid
XM25_RS22275	COG0745	RESPONSE REGULATOR receiver
XM25_RS22280	COG0704	Plays a role in the regulation of phosphate uptake
XM25_RS22285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XM25_RS22295	COG0573	inorganic phosphate transmembrane transporter activity
XM25_RS22300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XM25_RS22305	COG5002	protein histidine kinase activity
XM25_RS22310	COG2326	polyphosphate kinase activity
XM25_RS22320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XM25_RS22325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XM25_RS22340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XM25_RS22355	COG1064	alcohol dehydrogenase
XM25_RS22395	COG1846	Transcriptional regulator
XM25_RS22400	COG2197	response regulator
XM25_RS22410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XM25_RS22415	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
XM25_RS22435	COG0167	dihydroorotate dehydrogenase activity
XM25_RS22445	COG0572	uridine kinase
XM25_RS22450	COG1201	RNA secondary structure unwinding
XM25_RS22475	COG3773	Cell wall hydrolase
XM25_RS22545	COG4191	Histidine kinase
XM25_RS22545	COG0784	Response regulator, receiver
XM25_RS22595	COG2885	chlorophyll binding
XM25_RS22605	COG0840	transmembrane signaling receptor activity
XM25_RS22610	COG0840	transmembrane signaling receptor activity
XM25_RS22615	COG0840	transmembrane signaling receptor activity
XM25_RS22625	COG3108	Peptidase M15
XM25_RS22630	COG0840	transmembrane signaling receptor activity
XM25_RS22660	COG0840	transmembrane signaling receptor activity