locus-tag	class	description
H4N61_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
H4N61_RS00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
H4N61_RS00025	ENOG4108M8W	Monooxygenase
H4N61_RS00065	ENOG4105TX3	Histidine kinase
H4N61_RS00070	ENOG4108UYB	regulatoR
H4N61_RS00075	ENOG4105CC5	ABC transporter
H4N61_RS00080	ENOG4105CC5	ABC transporter
H4N61_RS00085	ENOG4105DIK	(ABC) transporter
H4N61_RS00115	ENOG4105X1N	Glycosyl transferase family 8
H4N61_RS00155	ENOG4108JQ1	Dehydrogenase
H4N61_RS00165	ENOG4107ZGG	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
H4N61_RS00170	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
H4N61_RS00185	ENOG4106UW1	Major Facilitator superfamily
H4N61_RS00195	ENOG4105D3R	alkyl hydroperoxide reductase
H4N61_RS00205	ENOG4105EAD	ABC transporter
H4N61_RS00210	ENOG4106PMH	Extracellular solute-binding protein family 3
H4N61_RS00215	ENOG4105ETT	transcriptional Regulator, LysR family
H4N61_RS00225	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
H4N61_RS00245	ENOG4105CPC	Aldo Keto reductase
H4N61_RS00250	ENOG4105C72	UPF0176 protein
H4N61_RS00280	ENOG4108ZX6	Electron transport protein SCO1 SenC
H4N61_RS00285	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
H4N61_RS00290	ENOG4106YAV	Domain of unknown function (DUF1508)
H4N61_RS00305	ENOG4105CAY	ferredoxin--nadp reductase
H4N61_RS00310	ENOG4108Z40	Transcriptional regulator
H4N61_RS00330	ENOG4107Z6I	Thiamine biosynthesis protein
H4N61_RS00335	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS00340	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS00350	ENOG4105CD3	dihydroorotase
H4N61_RS00355	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
H4N61_RS00360	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
H4N61_RS00365	ENOG4105C26	Dehydrogenase
H4N61_RS00370	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
H4N61_RS00375	ENOG4108R86	Transcriptional regulator
H4N61_RS00395	ENOG4108SHN	Glycosyl transferase, family 2
H4N61_RS00430	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
H4N61_RS00545	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
H4N61_RS00555	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
H4N61_RS00560	ENOG4105E98	transcriptional regulator DeoR family
H4N61_RS00575	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
H4N61_RS00580	ENOG4105DEF	Extracellular solute-binding protein, family 5
H4N61_RS00590	ENOG4108JQ7	(ABC) transporter
H4N61_RS00610	ENOG4105EAM	Na Pi-cotransporter
H4N61_RS00635	ENOG4105C26	Dehydrogenase
H4N61_RS00655	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
H4N61_RS00660	ENOG4105DJ9	glucan biosynthesis protein
H4N61_RS00685	ENOG4105MFQ	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity)
H4N61_RS00710	ENOG4105ETE	Transcriptional regulator (LacI family
H4N61_RS00715	ENOG4105C5H	ABC transporter
H4N61_RS00720	ENOG4105KPV	Transcriptional regulator
H4N61_RS00725	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
H4N61_RS00735	ENOG4105CPC	Aldo Keto reductase
H4N61_RS00740	ENOG4105DEF	Extracellular solute-binding protein, family 5
H4N61_RS00745	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS00750	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS00755	ENOG4105C3U	ABC transporter
H4N61_RS00760	ENOG4108JQ7	(ABC) transporter
H4N61_RS00775	ENOG41080Z8	PHOSPHOCARRIER protein
H4N61_RS00780	ENOG4105DAS	pts system
H4N61_RS00790	ENOG4105EB3	Histidine kinase
H4N61_RS00795	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
H4N61_RS00800	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
H4N61_RS00825	ENOG4105CNG	UPF0061 protein
H4N61_RS00830	ENOG4108Z0R	Transferase
H4N61_RS00840	ENOG4105BZN	citrate synthase
H4N61_RS00845	ENOG4105CR4	methylisocitrate lyase
H4N61_RS00850	ENOG4105BZU	Histidine kinase
H4N61_RS00855	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
H4N61_RS00860	ENOG4105C8Q	Methyl-accepting chemotaxis
H4N61_RS00865	ENOG4105I8F	Histidine kinase
H4N61_RS00880	ENOG4105C2M	dna polymerase I
H4N61_RS00885	ENOG4108VYJ	response regulator receiver protein
H4N61_RS00895	ENOG4108YZY	peptidylprolyl cis-trans isomerase
H4N61_RS00900	ENOG4108R3E	Dna-3-methyladenine glycosylase i
H4N61_RS00935	ENOG4105D3Q	Sugar transferase
H4N61_RS00955	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
H4N61_RS00980	ENOG4105EGZ	biosynthesis protein
H4N61_RS00985	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
H4N61_RS00995	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
H4N61_RS01000	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
H4N61_RS01045	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS01050	ENOG4107RCV	ABC transporter, permease
H4N61_RS01055	ENOG4105C6F	GntR Family Transcriptional Regulator
H4N61_RS01065	ENOG4105CNN	ABC, transporter
H4N61_RS01075	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
H4N61_RS01080	ENOG4105DIA	mandelate racemase muconate lactonizing
H4N61_RS01085	ENOG4105CHR	reductase
H4N61_RS01090	ENOG4105M4H	endoribonuclease L-psp
H4N61_RS01100	ENOG4107QZ7	Cellulose synthase catalytic subunit
H4N61_RS01120	ENOG4105E98	transcriptional regulator DeoR family
H4N61_RS01130	ENOG4105BZU	Histidine kinase
H4N61_RS01135	ENOG4108IPW	abc transporter atp-binding protein
H4N61_RS01140	ENOG4105CM4	permease protein
H4N61_RS01145	ENOG4105DHS	permease protein
H4N61_RS01165	ENOG4105BZ1	(ABC) transporter
H4N61_RS01170	ENOG4105BZ1	(ABC) transporter
H4N61_RS01180	ENOG4105C9U	ATP-dependent DNA helicase RecQ
H4N61_RS01185	ENOG4108VX5	3-methyladenine DNA glycosylase
H4N61_RS01195	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
H4N61_RS01205	ENOG4105BZ1	(ABC) transporter
H4N61_RS01210	ENOG4105C88	aminopeptidase
H4N61_RS01215	ENOG4105CSR	polyphosphate kinase 2
H4N61_RS01220	ENOG4105BZU	Histidine kinase
H4N61_RS01230	ENOG4105C8Y	Acetylornithine aminotransferase
H4N61_RS01235	ENOG4105DBV	ornithine carbamoyltransferase
H4N61_RS01255	ENOG41079KZ	Major Facilitator Superfamily
H4N61_RS01260	ENOG4105CFF	transcriptional regulator
H4N61_RS01280	ENOG4105BZU	Histidine kinase
H4N61_RS01285	ENOG4105DHP	deoxycytidine triphosphate deaminase
H4N61_RS01295	ENOG4106TNF	Periplasmic binding protein
H4N61_RS01305	ENOG4105DK7	lysyl-tRNA synthetase
H4N61_RS01320	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
H4N61_RS01345	ENOG4107QRT	dEAD DEAH box helicase
H4N61_RS01370	ENOG4108VCT	Sulfite exporter TauE/SafE
H4N61_RS01410	ENOG4105DIH	basic membrane
H4N61_RS01415	ENOG4108JQ9	ABC transporter
H4N61_RS01430	ENOG4105KG3	cytidine deaminase
H4N61_RS01440	ENOG4105C26	Dehydrogenase
H4N61_RS01455	ENOG4105EFX	secretion protein, HlyD family
H4N61_RS01465	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
H4N61_RS01470	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
H4N61_RS01475	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
H4N61_RS01480	ENOG4108UYE	Lactoylglutathione lyase
H4N61_RS01575	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
H4N61_RS01590	ENOG4105G9V	cytochrome C
H4N61_RS01595	ENOG4105CQC	Prephenate dehydratase
H4N61_RS01600	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
H4N61_RS01610	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
H4N61_RS01625	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
H4N61_RS01635	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
H4N61_RS01640	ENOG4105CGY	Dna recombination protein
H4N61_RS01650	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
H4N61_RS01655	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
H4N61_RS01660	ENOG4107QMP	dna polymerase iii subunits gamma and tau
H4N61_RS01670	ENOG4108KTU	conserved protein with FAD NAD(P)-binding domain
H4N61_RS01675	ENOG4108UQS	dipeptidase
H4N61_RS01690	ENOG4105DZG	Dehydrogenase
H4N61_RS01695	ENOG4105BZU	Histidine kinase
H4N61_RS01700	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
H4N61_RS01710	ENOG4108ZG0	Ompa motb domain protein
H4N61_RS01720	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
H4N61_RS01730	ENOG4108ZXC	Two component transcriptional regulator, luxr family
H4N61_RS01745	ENOG4105BZ9	Cytochrome C oxidase, subunit I
H4N61_RS01750	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
H4N61_RS01775	ENOG4105WH1	Two component transcriptional regulator luxr family
H4N61_RS01790	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
H4N61_RS01810	ENOG4108ZTZ	UPF0262 protein
H4N61_RS01815	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
H4N61_RS01820	ENOG4108Z03	MAF-like protein
H4N61_RS01825	ENOG4105VYE	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
H4N61_RS01835	ENOG4105Y3U	Transglycosylase-associated protein
H4N61_RS01850	ENOG4105BZU	Histidine kinase
H4N61_RS01870	ENOG4105D2H	Uronic isomerase
H4N61_RS01885	ENOG4105DX0	Hemolysin A
H4N61_RS01890	ENOG4108ZX6	Electron transport protein SCO1 SenC
H4N61_RS01895	ENOG41083BM	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
H4N61_RS01905	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
H4N61_RS01940	ENOG4105CG3	alpha amylase, catalytic region
H4N61_RS01955	ENOG4105BZJ	Electron transfer flavoprotein
H4N61_RS01960	ENOG4105C10	Electron transfer flavoprotein
H4N61_RS01965	ENOG4105CGF	Aromatic amino acid aminotransferase
H4N61_RS01970	ENOG4105D1F	ATP-binding protein
H4N61_RS01980	ENOG4108JQ6	ABC transporter
H4N61_RS01985	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS02015	ENOG4105K5G	30S ribosomal protein S21
H4N61_RS02030	ENOG4105CUT	histidyl-tRNA synthetase
H4N61_RS02040	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
H4N61_RS02055	ENOG41089I4	Inherit from COG: Glycosyl transferase, family 2
H4N61_RS02070	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
H4N61_RS02075	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
H4N61_RS02090	ENOG4105DFI	Membrane
H4N61_RS02100	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
H4N61_RS02115	ENOG4105DTN	riboflavin biosynthesis protein ribF
H4N61_RS02125	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
H4N61_RS02135	ENOG4105FE9	pseudouridine synthase
H4N61_RS02140	ENOG4106H78	methyltransferase
H4N61_RS02155	ENOG41090R7	Ferric uptake
H4N61_RS02160	ENOG4105FAV	ABC, transporter
H4N61_RS02165	ENOG4105FDK	ABC transporter
H4N61_RS02195	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
H4N61_RS02230	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
H4N61_RS02235	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
H4N61_RS02240	ENOG4105C01	Dihydroxy-acid dehydratase
H4N61_RS02245	ENOG4108MK9	spermidine N(1)-acetyltransferase
H4N61_RS02260	ENOG4105C12	Phosphoribosylglycinamide synthetase
H4N61_RS02265	ENOG4105D78	K07001 NTE family protein
H4N61_RS02270	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
H4N61_RS02275	ENOG4108Z6B	deaminase
H4N61_RS02285	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
H4N61_RS02290	ENOG4105FBA	Phospholipase Carboxylesterase
H4N61_RS02295	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
H4N61_RS02305	ENOG4105ECY	inositol monophosphatase
H4N61_RS02325	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
H4N61_RS02350	ENOG4105BZ9	Cytochrome C oxidase, subunit I
H4N61_RS02355	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
H4N61_RS02365	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
H4N61_RS02370	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
H4N61_RS02380	ENOG4105D98	threonine synthase
H4N61_RS02390	ENOG4105D9U	N-acetyltransferase
H4N61_RS02395	ENOG4105BZU	Histidine kinase
H4N61_RS02400	ENOG4108UJU	UPF0301 protein
H4N61_RS02410	ENOG4105EHV	domain protein
H4N61_RS02420	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4N61_RS02425	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4N61_RS02430	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
H4N61_RS02435	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
H4N61_RS02440	ENOG4105N5Q	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
H4N61_RS02450	ENOG4105VD1	ATP synthase subunit C
H4N61_RS02455	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
H4N61_RS02465	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
H4N61_RS02480	ENOG4105CEN	a g-specific adenine glycosylase
H4N61_RS02490	ENOG4105CEC	DNA methylase N-4 N-6
H4N61_RS02495	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
H4N61_RS02505	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
H4N61_RS02520	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
H4N61_RS02530	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
H4N61_RS02535	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
H4N61_RS02545	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
H4N61_RS02550	ENOG4105EAH	synthase
H4N61_RS02560	ENOG4108E8C	) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
H4N61_RS02570	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
H4N61_RS02575	ENOG4105XUP	Phage derived protein Gp49-like (DUF891)
H4N61_RS02585	ENOG4105NXH	GreA GreB family elongation factor
H4N61_RS02590	ENOG4108V0P	LemA family
H4N61_RS02600	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
H4N61_RS02605	ENOG4105CKW	Inner membrane protein yedI
H4N61_RS02610	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
H4N61_RS02620	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
H4N61_RS02625	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
H4N61_RS02635	ENOG4105F0V	Cell wall hydrolase
H4N61_RS02645	ENOG4108R7K	Metal Dependent Phosphohydrolase
H4N61_RS02650	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
H4N61_RS02665	ENOG4105NAE	bifunctional deaminase-reductase domain protein
H4N61_RS02685	ENOG4108RAV	Conserved protein
H4N61_RS02700	ENOG4105CQB	FAD linked oxidase domain protein
H4N61_RS02710	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
H4N61_RS02765	ENOG4105CXK	mandelate racemase muconate lactonizing
H4N61_RS02780	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
H4N61_RS02820	ENOG4105E5H	Transposase
H4N61_RS02825	ENOG4108YXQ	IS66 Orf2 family protein
H4N61_RS02855	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
H4N61_RS02875	ENOG4105D5G	Transposase
H4N61_RS02880	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
H4N61_RS02890	ENOG4105C0Z	ABC transporter
H4N61_RS02895	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
H4N61_RS02910	ENOG4108IV0	ABC, transporter
H4N61_RS02915	ENOG4108VUG	Enoyl-CoA hydratase
H4N61_RS02945	ENOG4105CHR	reductase
H4N61_RS02960	ENOG4105C2C	drug resistance transporter, Bcr CflA
H4N61_RS02980	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
H4N61_RS02985	ENOG4105HEI	LysR family (Transcriptional regulator
H4N61_RS02990	ENOG410846T	CoA-transferase family III
H4N61_RS02995	ENOG4105C5I	Dehydrogenase
H4N61_RS03005	ENOG4107F9Y	LysR family transcriptional regulator
H4N61_RS03015	ENOG4105BZU	Histidine kinase
H4N61_RS03040	ENOG4108SHN	Glycosyl transferase, family 2
H4N61_RS03065	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
H4N61_RS03080	ENOG4105D5G	Transposase
H4N61_RS03090	ENOG4105MEW	serine threonine protein phosphatase
H4N61_RS03115	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
H4N61_RS03150	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
H4N61_RS03155	ENOG4108WYP	Transcriptional regulator
H4N61_RS03160	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS03165	ENOG4105F38	ABC transporter, permease
H4N61_RS03170	ENOG4105D38	putrescine abc transporter
H4N61_RS03180	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
H4N61_RS03195	ENOG4105H3G	oxidoreductase
H4N61_RS03200	ENOG4105BZ1	(ABC) transporter
H4N61_RS03205	ENOG4105CYW	agmatinase
H4N61_RS03210	ENOG4108IMY	Transcriptional regulator
H4N61_RS03215	ENOG4108JEH	abc transporter atp-binding protein
H4N61_RS03220	ENOG4105E89	ABC transporter
H4N61_RS03225	ENOG4105DSP	amino acid AbC transporter
H4N61_RS03230	ENOG4106YG3	ABC transporter
H4N61_RS03250	ENOG4108JJB	ABC transporter
H4N61_RS03255	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
H4N61_RS03260	ENOG4107ZYJ	bioY protein
H4N61_RS03270	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
H4N61_RS03280	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS03290	ENOG4105BZ7	extracellular solute-binding protein family 1
H4N61_RS03295	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
H4N61_RS03300	ENOG4106N3A	copper homeostasis protein cutc
H4N61_RS03325	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
H4N61_RS03340	ENOG4106KNT	transcriptional regulator
H4N61_RS03365	ENOG4105CHR	reductase
H4N61_RS03380	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS03405	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H4N61_RS03410	ENOG4105NYY	transcriptional regulator, RpiR
H4N61_RS03430	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
H4N61_RS03435	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
H4N61_RS03455	ENOG4105EW9	transcriptional regulator AsnC family
H4N61_RS03460	ENOG4105C26	Dehydrogenase
H4N61_RS03470	ENOG4108JQ7	(ABC) transporter
H4N61_RS03475	ENOG4105C3U	ABC transporter
H4N61_RS03480	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS03485	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS03490	ENOG4105WBV	Transcriptional regulator
H4N61_RS03505	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
H4N61_RS03520	ENOG4108JQ5	ABC transporter
H4N61_RS03525	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS03540	ENOG4108DMH	HTH_ARAC
H4N61_RS03545	ENOG4105ETE	Transcriptional regulator (LacI family
H4N61_RS03550	ENOG4105C2J	ABC transporter
H4N61_RS03555	ENOG4105CNN	ABC, transporter
H4N61_RS03560	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
H4N61_RS03580	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
H4N61_RS03585	ENOG4108JJ8	(ABC) transporter
H4N61_RS03590	ENOG4108JJ9	ABC, transporter
H4N61_RS03595	ENOG4105C4M	(Ubiquinol oxidase) subunit I
H4N61_RS03600	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
H4N61_RS03615	ENOG4108Z66	YbaK ebsC protein
H4N61_RS03625	ENOG4105ETT	transcriptional Regulator, LysR family
H4N61_RS03635	ENOG4105C9F	isomerase
H4N61_RS03655	ENOG4105C2J	ABC transporter
H4N61_RS03665	ENOG4105F5R	ABC transporter
H4N61_RS03670	ENOG4105M10	Involved in the anomeric conversion of L-rhamnose (By similarity)
H4N61_RS03695	ENOG4105D7A	ATP-binding protein
H4N61_RS03720	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
H4N61_RS03730	ENOG4105D65	subunit l
H4N61_RS03740	ENOG4108ZE9	Monovalent cation H antiporter subunit C
H4N61_RS03745	ENOG4108JPZ	Monovalent cation H antiporter subunit D
H4N61_RS03750	ENOG4105SC1	monovalent cation H antiporter subunit E
H4N61_RS03755	ENOG41080TA	Multiple resistance and ph regulation protein f
H4N61_RS03760	ENOG4105KJM	monovalent cation h antiporter subunit g
H4N61_RS03765	ENOG4108YXV	Transcriptional regulator
H4N61_RS03780	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
H4N61_RS03790	ENOG4105BZU	Histidine kinase
H4N61_RS03835	ENOG4105JVC	membrAne
H4N61_RS03840	ENOG4105JVC	membrAne
H4N61_RS03855	ENOG4105JVC	membrAne
H4N61_RS03860	ENOG4105BZ4	penicillin-binding protein
H4N61_RS03865	ENOG4108ZZ3	UPF0260 protein
H4N61_RS03875	ENOG4105R8A	Heat shock protein
H4N61_RS03910	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
H4N61_RS03915	ENOG4105IFJ	Histidine kinase
H4N61_RS03930	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
H4N61_RS03945	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
H4N61_RS03950	ENOG4105DA4	cytochrome c-type biogenesis protein
H4N61_RS03955	ENOG4105KWW	Biogenesis protein
H4N61_RS03960	ENOG4105C0H	protease
H4N61_RS03965	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
H4N61_RS03980	ENOG4105BZU	Histidine kinase
H4N61_RS03985	ENOG4105CD8	aminopeptidase N
H4N61_RS03990	ENOG4105BZ1	(ABC) transporter
H4N61_RS04010	ENOG4105CEP	NADH dehydrogenase
H4N61_RS04030	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
H4N61_RS04040	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
H4N61_RS04045	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
H4N61_RS04055	ENOG4105BZU	Histidine kinase
H4N61_RS04060	ENOG4108XM1	transcriptional regulator AsnC family
H4N61_RS04065	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
H4N61_RS04070	ENOG4108PXI	ErfK YbiS YcfS YnhG
H4N61_RS04075	ENOG4105E66	phosphoriboisomerase A
H4N61_RS04085	ENOG4105DC8	reductase
H4N61_RS04090	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
H4N61_RS04095	ENOG4105C4K	Nad synthetase
H4N61_RS04100	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
H4N61_RS04115	ENOG4105C8N	cysteinyl-tRNA synthetase
H4N61_RS04130	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
H4N61_RS04135	ENOG4108WZM	domain protein
H4N61_RS04145	ENOG4108JJ7	ABC transporter
H4N61_RS04150	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
H4N61_RS04155	ENOG4105CHR	reductase
H4N61_RS04160	ENOG4107QKS	N-acylglucosamine 2-epimerase
H4N61_RS04165	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H4N61_RS04170	ENOG4105C7I	Dehydrogenase
H4N61_RS04180	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
H4N61_RS04195	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
H4N61_RS04220	ENOG4105DHQ	Histidine kinase
H4N61_RS04230	ENOG4105BZU	Histidine kinase
H4N61_RS04235	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
H4N61_RS04240	ENOG4107S76	domain protein
H4N61_RS04260	ENOG41080HT	Transcriptional regulator, arsr family
H4N61_RS04265	ENOG4105BZU	Histidine kinase
H4N61_RS04275	ENOG4105CH2	amidohydrolase
H4N61_RS04280	ENOG4105DU0	nucleoside hydrolase
H4N61_RS04285	ENOG4105CPN	adenine deaminase
H4N61_RS04305	ENOG4105NRK	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS04310	ENOG4105F38	ABC transporter, permease
H4N61_RS04320	ENOG4105CPN	adenine deaminase
H4N61_RS04325	ENOG4108DBC	nitroreductase
H4N61_RS04365	ENOG4105CJ1	ABC, transporter
H4N61_RS04375	ENOG4105C5Q	Transcriptional regulator
H4N61_RS04380	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS04405	ENOG4107TTA	Xylose isomerase domain protein TIM barrel
H4N61_RS04410	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
H4N61_RS04415	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
H4N61_RS04425	ENOG4108ERU	trap dicarboxylate transporter subunit DctP
H4N61_RS04435	ENOG4107S9B	Shikimate dehydrogenase
H4N61_RS04440	ENOG4108W9H	Tetr family transcriptional regulator
H4N61_RS04445	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
H4N61_RS04450	ENOG4107EJG	GntR family transcriptional regulator
H4N61_RS04455	ENOG41062B0	ABC transporter, permease
H4N61_RS04460	ENOG4107R9N	ABC transporter
H4N61_RS04465	ENOG4105C2J	ABC transporter
H4N61_RS04470	ENOG4107R5U	Periplasmic binding protein LacI transcriptional regulator
H4N61_RS04490	ENOG4105DAB	fumarate reductase succinate dehydrogenase flavoprotein domain protein
H4N61_RS04515	ENOG4105E98	transcriptional regulator DeoR family
H4N61_RS04520	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
H4N61_RS04530	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS04545	ENOG4105EAM	Na Pi-cotransporter
H4N61_RS04565	ENOG4105BZU	Histidine kinase
H4N61_RS04585	ENOG4105Q9Y	Universal stress protein
H4N61_RS04595	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
H4N61_RS04605	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
H4N61_RS04615	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
H4N61_RS04620	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
H4N61_RS04625	ENOG41081YB	ApbE family
H4N61_RS04645	ENOG4107RCV	ABC transporter, permease
H4N61_RS04650	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS04665	ENOG4105E98	transcriptional regulator DeoR family
H4N61_RS04675	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
H4N61_RS04680	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
H4N61_RS04705	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
H4N61_RS04715	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
H4N61_RS04720	ENOG4105BZU	Histidine kinase
H4N61_RS04730	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
H4N61_RS04740	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
H4N61_RS04745	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
H4N61_RS04760	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
H4N61_RS04775	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
H4N61_RS04780	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
H4N61_RS04785	ENOG4105BZU	Histidine kinase
H4N61_RS04790	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
H4N61_RS04800	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
H4N61_RS04805	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
H4N61_RS04810	ENOG4105HHA	aminodeoxychorismate lyase
H4N61_RS04815	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
H4N61_RS04820	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
H4N61_RS04870	ENOG4105C5H	ABC transporter
H4N61_RS04880	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
H4N61_RS04895	ENOG4105S8Q	sugar efflux transporter
H4N61_RS04905	ENOG4108J2R	molybdopterin oxidoreductase
H4N61_RS04975	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
H4N61_RS04990	ENOG4108JPW	Aminotransferase
H4N61_RS04995	ENOG4105ETT	transcriptional Regulator, LysR family
H4N61_RS05000	ENOG4108Z86	Glutamine amidotransferase
H4N61_RS05015	ENOG4105F38	ABC transporter, permease
H4N61_RS05020	ENOG4105D38	putrescine abc transporter
H4N61_RS05025	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS05030	ENOG4105C26	Dehydrogenase
H4N61_RS05035	ENOG4105C5Q	Transcriptional regulator
H4N61_RS05045	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
H4N61_RS05050	ENOG4105GIJ	Glycine betaine
H4N61_RS05055	ENOG4108HQS	Glycine betaine
H4N61_RS05060	ENOG4108IJ7	Glycine betaine
H4N61_RS05070	ENOG4108UXE	Protein tyrosine phosphatase
H4N61_RS05080	ENOG4105D6J	arsenicaL-resistance protein
H4N61_RS05090	ENOG4105CAU	Arsenical resistance protein, ArsH
H4N61_RS05095	ENOG4107SDU	Methyl-accepting chemotaxis
H4N61_RS05100	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
H4N61_RS05135	ENOG4105C26	Dehydrogenase
H4N61_RS05140	ENOG4107RQ0	Maleylacetate reductase
H4N61_RS05160	ENOG4105T16	Transcriptional regulator (AraC family)
H4N61_RS05170	ENOG4105C0Z	ABC transporter
H4N61_RS05175	ENOG4108IV0	ABC, transporter
H4N61_RS05180	ENOG4105C32	Amino acid ABC transporter (Permease)
H4N61_RS05185	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
H4N61_RS05195	ENOG410904N	short-chain dehydrogenase reductase
H4N61_RS05210	ENOG4105KPV	Transcriptional regulator
H4N61_RS05225	ENOG4108ZZF	transport protein (ExbD)
H4N61_RS05235	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
H4N61_RS05260	ENOG4105E0A	ABC, transporter
H4N61_RS05265	ENOG4105DQ5	transport system permease protein
H4N61_RS05270	ENOG4105EBR	Carboxylesterase
H4N61_RS05370	ENOG4105CK2	sodium dicarboxylate symporter
H4N61_RS05390	ENOG4105E6M	Sulphatase-modifying factor protein
H4N61_RS05395	ENOG4105CBG	Sulfatase
H4N61_RS05430	ENOG4105E0A	ABC, transporter
H4N61_RS05435	ENOG4105EHG	Permease protein
H4N61_RS05440	ENOG4105S10	periplasmic binding protein
H4N61_RS05450	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS05470	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
H4N61_RS05475	ENOG41061H0	Monooxygenase
H4N61_RS05485	ENOG4105KME	endoribonuclease L-psp
H4N61_RS05495	ENOG41061H0	Monooxygenase
H4N61_RS05505	ENOG4105C26	Dehydrogenase
H4N61_RS05510	ENOG4105ERH	Fumarylacetoacetate hydrolase
H4N61_RS05530	ENOG4108PVQ	transcriptional regulator
H4N61_RS05570	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
H4N61_RS05585	ENOG4106517	Short-chain dehydrogenase reductase Sdr
H4N61_RS05595	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
H4N61_RS05600	ENOG4105CHR	reductase
H4N61_RS05665	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
H4N61_RS05695	ENOG4105NQN	cytochrome C
H4N61_RS05705	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
H4N61_RS05715	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
H4N61_RS05720	ENOG4108UQ8	endoribonuclease L-psp
H4N61_RS05730	ENOG4108RVA	ribokinase
H4N61_RS05745	ENOG4108JQ9	ABC transporter
H4N61_RS05750	ENOG4107TFB	basic membrane
H4N61_RS05765	ENOG4105BZS	acriflavin resistance protein
H4N61_RS05770	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
H4N61_RS05775	ENOG4105D0S	secretion protein (HlyD
H4N61_RS05785	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H4N61_RS05795	ENOG4105CE4	GlcNAc 6-P deacetylase
H4N61_RS05820	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
H4N61_RS05825	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
H4N61_RS05835	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
H4N61_RS05845	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
H4N61_RS05850	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
H4N61_RS05855	ENOG4105C3F	Signal peptidase i
H4N61_RS05860	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
H4N61_RS05865	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
H4N61_RS05870	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
H4N61_RS05880	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
H4N61_RS05885	ENOG4105C8Q	Methyl-accepting chemotaxis
H4N61_RS05895	ENOG4105CKK	Glycosyl transferase, family 2
H4N61_RS05900	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
H4N61_RS05920	ENOG4105D52	delta-aminolevulinic acid dehydratase
H4N61_RS05950	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
H4N61_RS05955	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
H4N61_RS05985	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
H4N61_RS05990	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
H4N61_RS05995	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
H4N61_RS06000	ENOG4105WJX	transcriptional regulator MERR family
H4N61_RS06010	ENOG4108SXK	Transporter Drug Metabolite Exporter family
H4N61_RS06055	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
H4N61_RS06060	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
H4N61_RS06080	ENOG4106A3M	Cytochrome p-450
H4N61_RS06090	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
H4N61_RS06095	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
H4N61_RS06100	ENOG41066UZ	arginase EC 3.5.3.1
H4N61_RS06105	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
H4N61_RS06115	ENOG4105CHM	Aminotransferase
H4N61_RS06120	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
H4N61_RS06135	ENOG4105D6E	homoserine dehydrogenase
H4N61_RS06140	ENOG4105CBT	Fructose-1,6-bisphosphatase
H4N61_RS06145	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
H4N61_RS06150	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
H4N61_RS06175	ENOG4108UYE	Lactoylglutathione lyase
H4N61_RS06180	ENOG4105VEQ	Cold shock protein
H4N61_RS06190	ENOG4108UT2	hemolysin iii
H4N61_RS06195	ENOG4105MHT	Transcriptional regulator, ARSR family
H4N61_RS06205	ENOG4105D1F	ATP-binding protein
H4N61_RS06210	ENOG41067MG	lrgb family
H4N61_RS06215	ENOG4105VAW	lrga family
H4N61_RS06235	ENOG4108JQ6	ABC transporter
H4N61_RS06240	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS06250	ENOG4105DEF	Extracellular solute-binding protein, family 5
H4N61_RS06380	ENOG4105Y2X	UPF0335 protein
H4N61_RS06445	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
H4N61_RS06480	ENOG4108MDF	Phage Portal Protein
H4N61_RS06485	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
H4N61_RS06570	ENOG4105EXC	Acyl-transferase
H4N61_RS06575	ENOG4105EAQ	(twin-arginine translocation) pathway signal
H4N61_RS06605	ENOG4105ETE	Transcriptional regulator (LacI family
H4N61_RS06610	ENOG4108JP0	extracellular solute-binding protein family 1
H4N61_RS06625	ENOG4108IJ9	(ABC) transporter
H4N61_RS06680	ENOG4105C28	cystathionine
H4N61_RS06685	ENOG4107QXX	ABC transporter
H4N61_RS06690	ENOG4105EZ7	amino acid ABC transporter
H4N61_RS06695	ENOG4105DRP	amino acid AbC transporter
H4N61_RS06700	ENOG4105CDA	abc transporter atp-binding protein
H4N61_RS06705	ENOG4107QXX	ABC transporter
H4N61_RS06710	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
H4N61_RS06715	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
H4N61_RS06725	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
H4N61_RS06735	ENOG4105EU0	Major facilitator Superfamily
H4N61_RS06755	ENOG4105DKK	Benzoate
H4N61_RS06775	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
H4N61_RS06790	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
H4N61_RS06805	ENOG4107S1E	Beta-lactamase
H4N61_RS06810	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
H4N61_RS06815	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
H4N61_RS06820	ENOG4105C75	arginyL-tRNA synthetase
H4N61_RS06830	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
H4N61_RS06835	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
H4N61_RS06840	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
H4N61_RS06845	ENOG41081BE	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
H4N61_RS06850	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
H4N61_RS06855	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
H4N61_RS06860	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
H4N61_RS06875	ENOG4105VIE	preprotein translocase, subunit YajC
H4N61_RS06900	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
H4N61_RS06915	ENOG4105KVH	Transcriptional regulator
H4N61_RS06920	ENOG4105DZ1	carboxypeptidase
H4N61_RS06925	ENOG4105VFE	sira family
H4N61_RS06940	ENOG4105BZ1	(ABC) transporter
H4N61_RS06945	ENOG4105DQ5	transport system permease protein
H4N61_RS06950	ENOG4105TVJ	transport system, permease
H4N61_RS06955	ENOG4105E0A	ABC, transporter
H4N61_RS06995	ENOG4105C8Q	Methyl-accepting chemotaxis
H4N61_RS07010	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
H4N61_RS07020	ENOG4105DR5	peptidase
H4N61_RS07025	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H4N61_RS07035	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
H4N61_RS07040	ENOG4105DHZ	alpha beta
H4N61_RS07060	ENOG4105JRK	feS assembly protein SufD
H4N61_RS07065	ENOG4105C9B	Cysteine desulfurase
H4N61_RS07070	ENOG4105VG1	fes assembly suf system protein
H4N61_RS07075	ENOG4108Z4V	iron-sulfur cluster assembly
H4N61_RS07080	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
H4N61_RS07085	ENOG4106TD9	Diguanylate cyclase
H4N61_RS07090	ENOG4105C1J	atp-dependent rna helicase
H4N61_RS07095	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
H4N61_RS07100	ENOG4105D5G	Transposase
H4N61_RS07105	ENOG4105C5H	ABC transporter
H4N61_RS07120	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
H4N61_RS07130	ENOG4108YZA	Nitrogen regulatory protein pii
H4N61_RS07135	ENOG4105C5F	glutamine synthetase
H4N61_RS07170	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
H4N61_RS07190	ENOG4105C37	(CBS) domain
H4N61_RS07205	ENOG4105HFZ	Membrane
H4N61_RS07225	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
H4N61_RS07230	ENOG4105DEF	Extracellular solute-binding protein, family 5
H4N61_RS07235	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS07240	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS07245	ENOG4105C3U	ABC transporter
H4N61_RS07250	ENOG4108JQ7	(ABC) transporter
H4N61_RS07270	ENOG4108IV0	ABC, transporter
H4N61_RS07275	ENOG4105C0Z	ABC transporter
H4N61_RS07280	ENOG4105C32	Amino acid ABC transporter (Permease)
H4N61_RS07290	ENOG4105CP9	extracellular ligand-binding receptor
H4N61_RS07295	ENOG4105BZU	Histidine kinase
H4N61_RS07300	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
H4N61_RS07310	ENOG4108IJ9	(ABC) transporter
H4N61_RS07315	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
H4N61_RS07320	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
H4N61_RS07340	ENOG4105WH1	Two component transcriptional regulator luxr family
H4N61_RS07365	ENOG4105CHU	acetyl-coa acetyltransferase
H4N61_RS07370	ENOG4107QNJ	CoA-transferase subunit B
H4N61_RS07380	ENOG4107HP6	Transcriptional regulator
H4N61_RS07400	ENOG4105E4E	Thioester reductase domain-containing protein
H4N61_RS07420	ENOG4105E9F	Enoyl-CoA hydratase
H4N61_RS07435	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
H4N61_RS07440	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
H4N61_RS07445	ENOG41072AC	4-hydroxybenzoate 3-monooxygenase
H4N61_RS07455	ENOG4105DDW	LysR family Transcriptional regulator
H4N61_RS07465	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
H4N61_RS07470	ENOG4105EU7	Protocatechuate 3,4-dioxygenase, beta
H4N61_RS07475	ENOG4105RM9	Protocatechuate 3,4-dioxygenase alpha
H4N61_RS07480	ENOG4107RAW	3-carboxy-cis-cis-muconate cycloisomerase
H4N61_RS07500	ENOG4105E2R	ROK family
H4N61_RS07505	ENOG4107FKK	extracellular solute-binding protein family 1
H4N61_RS07515	ENOG4105DRS	transport system, permease
H4N61_RS07520	ENOG4106IQC	argininosuccinate lyase
H4N61_RS07530	ENOG4107Y7Q	pfkb domain protein
H4N61_RS07535	ENOG4105FDP	GntR family transcriptional regulator
H4N61_RS07540	ENOG4105DEF	Extracellular solute-binding protein, family 5
H4N61_RS07545	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS07555	ENOG4108JQ7	(ABC) transporter
H4N61_RS07560	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
H4N61_RS07565	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
H4N61_RS07595	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H4N61_RS07600	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
H4N61_RS07605	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H4N61_RS07610	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
H4N61_RS07615	ENOG4105GKE	subunit e
H4N61_RS07625	ENOG4107QIZ	NADH dehydrogenase
H4N61_RS07630	ENOG4107R0R	NADH dehydrogenase subunit g
H4N61_RS07635	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
H4N61_RS07640	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
H4N61_RS07645	ENOG4105DF2	NADH dehydrogenase subunit j
H4N61_RS07650	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
H4N61_RS07655	ENOG4105D65	subunit l
H4N61_RS07660	ENOG4105C8S	subunit m
H4N61_RS07665	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
H4N61_RS07670	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
H4N61_RS07685	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
H4N61_RS07695	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
H4N61_RS07705	ENOG4105CE9	30S ribosomal protein S2
H4N61_RS07710	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
H4N61_RS07720	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
H4N61_RS07725	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
H4N61_RS07740	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4N61_RS07745	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
H4N61_RS07750	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
H4N61_RS07755	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
H4N61_RS07760	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
H4N61_RS07765	ENOG4105BZN	citrate synthase
H4N61_RS07785	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
H4N61_RS07790	ENOG4108RTU	Aldolase
H4N61_RS07795	ENOG4105EI3	2-dehydro-3-deoxygalactonokinase EC 2.7.1.58
H4N61_RS07805	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
H4N61_RS07815	ENOG4108JQ9	ABC transporter
H4N61_RS07830	ENOG4105DZC	cytosine deaminase
H4N61_RS07835	ENOG4105DRS	transport system, permease
H4N61_RS07850	ENOG4108IJ9	(ABC) transporter
H4N61_RS07855	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
H4N61_RS07865	ENOG4108NIX	Factor ChrR
H4N61_RS07870	ENOG4105K6V	RNA polymerase
H4N61_RS07885	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
H4N61_RS07890	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
H4N61_RS07895	ENOG4105DK0	Indole-3-glycerol phosphate synthase
H4N61_RS07900	ENOG4107QYG	anthranilate phosphoribosyltransferase
H4N61_RS07905	ENOG4105DDQ	anthranilate synthase
H4N61_RS07910	ENOG4105CRQ	synthase (Component I)
H4N61_RS07920	ENOG4105CP7	Triose-phosphate isomerase
H4N61_RS07930	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
H4N61_RS07945	ENOG4105CSH	Transporter
H4N61_RS07960	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
H4N61_RS07980	ENOG4105C3R	Methionine synthase
H4N61_RS07990	ENOG4105DZ1	carboxypeptidase
H4N61_RS07995	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
H4N61_RS08000	ENOG4107QRG	dna polymerase iii
H4N61_RS08010	ENOG4105F8V	Hydrolase, tatD family
H4N61_RS08020	ENOG4105D01	(LipO)protein
H4N61_RS08025	ENOG4108UMI	ABC transporter, permease
H4N61_RS08030	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS08040	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS08045	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
H4N61_RS08065	ENOG4105ETE	Transcriptional regulator (LacI family
H4N61_RS08070	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
H4N61_RS08085	ENOG4105ECI	YeeC-like protein
H4N61_RS08090	ENOG4105F6A	helicase
H4N61_RS08095	ENOG4105D85	methylase
H4N61_RS08105	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
H4N61_RS08115	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
H4N61_RS08165	ENOG4105DXN	mazG family
H4N61_RS08175	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
H4N61_RS08180	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
H4N61_RS08185	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
H4N61_RS08190	ENOG4105ES5	Histidine kinase
H4N61_RS08195	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
H4N61_RS08200	ENOG4105CUX	Signal transduction histidine kinase
H4N61_RS08205	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
H4N61_RS08210	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
H4N61_RS08225	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
H4N61_RS08235	ENOG4105FYV	Amp nucleosidase
H4N61_RS08255	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
H4N61_RS08260	ENOG4107QN2	dihydrolipoyl dehydrogenase
H4N61_RS08270	ENOG4105C7S	Dehydrogenase
H4N61_RS08275	ENOG4105CPP	Dehydrogenase, E1 component
H4N61_RS08280	ENOG4108JYK	Dehydrogenase
H4N61_RS08295	ENOG4105C6K	Malic enzyme
H4N61_RS08300	ENOG4105BZU	Histidine kinase
H4N61_RS08305	ENOG4105C9M	aspartyl-trna synthetase
H4N61_RS08310	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
H4N61_RS08320	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
H4N61_RS08335	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
H4N61_RS08340	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
H4N61_RS08345	ENOG4108Q5Y	Membrane
H4N61_RS08350	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
H4N61_RS08370	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
H4N61_RS08380	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
H4N61_RS08390	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
H4N61_RS08395	ENOG4105CXT	aspartate transcarbamylase
H4N61_RS08405	ENOG4108IGT	Dipeptidase
H4N61_RS08415	ENOG4105D4A	Cell wall formation (By similarity)
H4N61_RS08420	ENOG4105C79	DNA protecting protein DprA
H4N61_RS08425	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
H4N61_RS08430	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
H4N61_RS08440	ENOG4105W0E	50S ribosomal protein L33
H4N61_RS08450	ENOG4108UXN	response regulator
H4N61_RS08460	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
H4N61_RS08475	ENOG4105K59	histidine triad (HIT) protein
H4N61_RS08485	ENOG4105CHH	sulfate transporter
H4N61_RS08495	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS08500	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS08515	ENOG4108J59	Extracellular solute-binding protein, family 5
H4N61_RS08525	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
H4N61_RS08530	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
H4N61_RS08545	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS08550	ENOG4105D81	ABC transporter, permease
H4N61_RS08555	ENOG4105D38	putrescine abc transporter
H4N61_RS08575	ENOG4105HF0	Membrane
H4N61_RS08590	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
H4N61_RS08595	ENOG4107YCY	Transcriptional regulator
H4N61_RS08600	ENOG4105CXK	mandelate racemase muconate lactonizing
H4N61_RS08615	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
H4N61_RS08625	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
H4N61_RS08630	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
H4N61_RS08665	ENOG4107R9N	ABC transporter
H4N61_RS08670	ENOG4105CNN	ABC, transporter
H4N61_RS08675	ENOG4105C2J	ABC transporter
H4N61_RS08680	ENOG4105DIA	mandelate racemase muconate lactonizing
H4N61_RS08755	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
H4N61_RS08760	ENOG4105DZ1	carboxypeptidase
H4N61_RS08770	ENOG4107QJQ	Mate efflux family protein
H4N61_RS08795	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
H4N61_RS08800	ENOG4105C03	ribonuclease
H4N61_RS08810	ENOG4108YYQ	gCN5-related N-acetyltransferase
H4N61_RS08825	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
H4N61_RS08830	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
H4N61_RS08835	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
H4N61_RS08840	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
H4N61_RS08865	ENOG4107RTZ	reductase
H4N61_RS08940	ENOG4105DRS	transport system, permease
H4N61_RS08960	ENOG4105BZU	Histidine kinase
H4N61_RS08965	ENOG4105BZU	Histidine kinase
H4N61_RS08980	ENOG4105GIJ	Glycine betaine
H4N61_RS08985	ENOG4108HQS	Glycine betaine
H4N61_RS08990	ENOG4108IJ7	Glycine betaine
H4N61_RS08995	ENOG4105CHR	reductase
H4N61_RS09035	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
H4N61_RS09085	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
H4N61_RS09095	ENOG4105ETE	Transcriptional regulator (LacI family
H4N61_RS09110	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
H4N61_RS09125	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
H4N61_RS09130	ENOG4105ETE	Transcriptional regulator (LacI family
H4N61_RS09140	ENOG4105F38	ABC transporter, permease
H4N61_RS09150	ENOG4108IJ6	ABC transporter
H4N61_RS09160	ENOG4105ECY	inositol monophosphatase
H4N61_RS09170	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS09180	ENOG4105EG2	ABC transporter, permease
H4N61_RS09185	ENOG4105D56	permease protein
H4N61_RS09195	ENOG4105FKQ	transcriptional regulator
H4N61_RS09210	ENOG4105CJ1	ABC, transporter
H4N61_RS09220	ENOG4107RP9	extracellular solute-binding protein, family 3
H4N61_RS09235	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
H4N61_RS09240	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
H4N61_RS09260	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS09285	ENOG4105EF1	ribulokinase
H4N61_RS09300	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
H4N61_RS09305	ENOG4105C08	Histidine kinase
H4N61_RS09315	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
H4N61_RS09320	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
H4N61_RS09335	ENOG4105CXK	mandelate racemase muconate lactonizing
H4N61_RS09345	ENOG4105DRS	transport system, permease
H4N61_RS09350	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
H4N61_RS09370	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
H4N61_RS09410	ENOG4105NTD	Inherit from COG: Hydrolase
H4N61_RS09415	ENOG4105WJV	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS09420	ENOG4108IJ8	ABC transporter
H4N61_RS09425	ENOG4107T5X	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS09430	ENOG4107SI7	Substrate-binding region of abc-type glycine betaine transport system
H4N61_RS09440	ENOG4105ETE	Transcriptional regulator (LacI family
H4N61_RS09455	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
H4N61_RS09460	ENOG4108HWV	)-transporter
H4N61_RS09465	ENOG4105C2J	ABC transporter
H4N61_RS09480	ENOG4105EDK	PfkB domain protein
H4N61_RS09485	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
H4N61_RS09495	ENOG4105DH8	myo-inositol catabolism
H4N61_RS09510	ENOG4105BZM	domain protein
H4N61_RS09515	ENOG4105CPC	Aldo Keto reductase
H4N61_RS09520	ENOG4105CXK	mandelate racemase muconate lactonizing
H4N61_RS09525	ENOG4108PVQ	transcriptional regulator
H4N61_RS09545	ENOG4108IJ9	(ABC) transporter
H4N61_RS09550	ENOG4105CXK	mandelate racemase muconate lactonizing
H4N61_RS09575	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS09585	ENOG4105DEF	Extracellular solute-binding protein, family 5
H4N61_RS09600	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
H4N61_RS09615	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
H4N61_RS09620	ENOG4105WAZ	(Glutaredoxin-like protein) NrdH
H4N61_RS09630	ENOG4108R99	pseudouridine synthase
H4N61_RS09635	ENOG4105FCD	Major Facilitator
H4N61_RS09665	ENOG4105D00	flagellar biosynthetic protein flhB
H4N61_RS09675	ENOG4107R8N	Glycosyl transferase, family 2
H4N61_RS09685	ENOG4105BZU	Histidine kinase
H4N61_RS09695	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
H4N61_RS09700	ENOG4105CFF	transcriptional regulator
H4N61_RS09710	ENOG4105C32	Amino acid ABC transporter (Permease)
H4N61_RS09715	ENOG4108HWW	ABC transporter
H4N61_RS09720	ENOG4105C0Z	ABC transporter
H4N61_RS09725	ENOG4108IV0	ABC, transporter
H4N61_RS09730	ENOG4105E7W	lamb ycsf family protein
H4N61_RS09755	ENOG4105EJQ	L-serine dehydratase
H4N61_RS09765	ENOG4105CZZ	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
H4N61_RS09770	ENOG4105ETE	Transcriptional regulator (LacI family
H4N61_RS09775	ENOG4105ETE	Transcriptional regulator (LacI family
H4N61_RS09780	ENOG4105CNT	hydrolase family 2
H4N61_RS09785	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS09860	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
H4N61_RS09865	ENOG4105EE5	Membrane protein terC
H4N61_RS09885	ENOG4107NKQ	Flavinator of succinate dehydrogenase
H4N61_RS09890	ENOG4105CB5	ATP-dependent DNA helicase recG
H4N61_RS09895	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
H4N61_RS09900	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
H4N61_RS09925	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
H4N61_RS09930	ENOG4107QP8	phosphohexose isomerase
H4N61_RS09950	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
H4N61_RS09970	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
H4N61_RS09980	ENOG4108NIW	Leucine export protein LeuE
H4N61_RS10005	ENOG4105BZU	Histidine kinase
H4N61_RS10015	ENOG4108UUM	single-stranded DNA-binding protein
H4N61_RS10020	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
H4N61_RS10030	ENOG4108RXX	maleylacetoacetate isomerase
H4N61_RS10035	ENOG4105CJW	magnesium transporter
H4N61_RS10075	ENOG4105DD5	Flagellar motor switch protein
H4N61_RS10080	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
H4N61_RS10095	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
H4N61_RS10105	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
H4N61_RS10110	ENOG4108I5D	sulfate abc transporter
H4N61_RS10115	ENOG4105ECW	sulfate abc transporter
H4N61_RS10120	ENOG4105EEI	dihydropteroate synthase
H4N61_RS10125	ENOG4105KRF	dihydroneopterin aldolase
H4N61_RS10130	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H4N61_RS10140	ENOG4107XGZ	Hydrolase
H4N61_RS10145	ENOG4105EI2	Pseudouridine synthase
H4N61_RS10150	ENOG41082CG	Protein CrcB homolog
H4N61_RS10155	ENOG4105D1H	recombination factor protein RarA
H4N61_RS10160	ENOG4105C0H	protease
H4N61_RS10175	ENOG4108ZT0	50S ribosomal protein l17
H4N61_RS10180	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
H4N61_RS10185	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
H4N61_RS10190	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H4N61_RS10195	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
H4N61_RS10200	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
H4N61_RS10205	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
H4N61_RS10210	ENOG41084HQ	50S ribosomal protein L30
H4N61_RS10215	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
H4N61_RS10220	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
H4N61_RS10225	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
H4N61_RS10235	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
H4N61_RS10240	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H4N61_RS10245	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
H4N61_RS10250	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
H4N61_RS10255	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
H4N61_RS10260	ENOG41083MP	50s ribosomal protein l29
H4N61_RS10265	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
H4N61_RS10270	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
H4N61_RS10275	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
H4N61_RS10280	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
H4N61_RS10285	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H4N61_RS10290	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
H4N61_RS10295	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
H4N61_RS10300	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
H4N61_RS10305	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
H4N61_RS10310	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
H4N61_RS10315	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
H4N61_RS10320	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
H4N61_RS10325	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
H4N61_RS10330	ENOG4105CAY	ferredoxin--nadp reductase
H4N61_RS10335	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
H4N61_RS10340	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
H4N61_RS10345	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
H4N61_RS10350	ENOG4108VZM	50s ribosomal protein L10
H4N61_RS10355	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
H4N61_RS10360	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
H4N61_RS10370	ENOG4105PM1	preprotein translocase subunit SecE
H4N61_RS10395	ENOG4105BZU	Histidine kinase
H4N61_RS10415	ENOG4105C2N	RNA methyltransferase TrmH family group 3
H4N61_RS10435	ENOG4108UPT	UPF0178 protein
H4N61_RS10440	ENOG4107QPD	alcohol dehydrogenase
H4N61_RS10455	ENOG4108HWW	ABC transporter
H4N61_RS10460	ENOG4105DFW	ABC transporter
H4N61_RS10480	ENOG4105C11	sulfate adenylyltransferase), subunit 2
H4N61_RS10520	ENOG4105CAT	Cytidine monophosphate kinase
H4N61_RS10590	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
H4N61_RS10670	ENOG410903D	sensor protein
H4N61_RS10675	ENOG4105BZU	Histidine kinase
H4N61_RS10680	ENOG4105CG5	Glycosyl transferase (Group 1
H4N61_RS10705	ENOG4105WEF	catalase
H4N61_RS10710	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
H4N61_RS10745	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
H4N61_RS10775	ENOG4105JVC	membrAne
H4N61_RS10795	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
H4N61_RS10830	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
H4N61_RS10835	ENOG4108YZN	class I peptide chain release factor
H4N61_RS10845	ENOG4105C22	threonyL-tRNA synthetase
H4N61_RS10850	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
H4N61_RS10860	ENOG4105EUJ	GTP cyclohydrolase i
H4N61_RS10865	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
H4N61_RS10905	ENOG4105D7W	serine acetyltransferase
H4N61_RS10935	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
H4N61_RS10940	ENOG4105CHR	reductase
H4N61_RS10960	ENOG4105D3G	Pseudouridine synthase
H4N61_RS10965	ENOG4105DJV	ribulose-phosphate 3-epimerase
H4N61_RS10970	ENOG41081YN	resistaNce protein
H4N61_RS10975	ENOG4105C83	adenylosuccinate lyase
H4N61_RS11010	ENOG4107QPR	SAICAR synthetase
H4N61_RS11015	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
H4N61_RS11020	ENOG4105C8Q	Methyl-accepting chemotaxis
H4N61_RS11030	ENOG4107QIV	Cytochrome c biogenesis protein
H4N61_RS11035	ENOG4105W5Q	DNA repair protein (RadC
H4N61_RS11040	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
H4N61_RS11045	ENOG4107TH8	cina domain protein
H4N61_RS11050	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
H4N61_RS11070	ENOG4107YYT	May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity)
H4N61_RS11085	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
H4N61_RS11090	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
H4N61_RS11110	ENOG4105M2J	Glutaredoxin
H4N61_RS11125	ENOG4105D2S	major facilitator superfamily
H4N61_RS11130	ENOG4105ECY	inositol monophosphatase
H4N61_RS11135	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
H4N61_RS11140	ENOG4108DQG	in Escherichia coli SbmA is involved in uptake of microcin J25
H4N61_RS11190	ENOG4105DFI	Membrane
H4N61_RS11195	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
H4N61_RS11200	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
H4N61_RS11215	ENOG4105D00	flagellar biosynthetic protein flhB
H4N61_RS11220	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
H4N61_RS11225	ENOG41082PJ	flagellar biosynthetic protein fliQ
H4N61_RS11230	ENOG4105UVF	flagellar hook-basal body complex protein fliE
H4N61_RS11235	ENOG4108ZC9	flagellar basal-body rod protein flgc
H4N61_RS11240	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
H4N61_RS11250	ENOG4105CN7	Flagellar biosynthetic protein FliP
H4N61_RS11275	ENOG4105X6C	Flagellar basal body-associated protein FliL
H4N61_RS11280	ENOG4105KTQ	flagellar basal-body rod protein
H4N61_RS11285	ENOG4105CGA	flagellar basal-body rod protein FlgG
H4N61_RS11300	ENOG4105CTD	carboxy-peptidase
H4N61_RS11325	ENOG4106909	Flagellar assembly regulator FliX
H4N61_RS11330	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
H4N61_RS11345	ENOG4105I03	Flagellin
H4N61_RS11360	ENOG4105I03	Flagellin
H4N61_RS11365	ENOG4105IE4	repressor protein FlbT
H4N61_RS11395	ENOG4105CVG	Homoserine O-transsuccinylase
H4N61_RS11400	ENOG4105CM6	amino acid regulated cytosolic protein
H4N61_RS11410	ENOG4105BZU	Histidine kinase
H4N61_RS11420	ENOG4105CAY	ferredoxin--nadp reductase
H4N61_RS11425	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
H4N61_RS11430	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
H4N61_RS11440	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
H4N61_RS11445	ENOG4107Z7P	Ferredoxin
H4N61_RS11455	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
H4N61_RS11475	ENOG4105D8G	Major Facilitator superfamily
H4N61_RS11485	ENOG4105D17	glycoside hydrolase, family 3 domain protein
H4N61_RS11490	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
H4N61_RS11510	ENOG4108ZCF	integral membrane protein
H4N61_RS11540	ENOG4105CIH	Imidazole acetol-phosphate transaminase
H4N61_RS11550	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
H4N61_RS11565	ENOG4105JAB	phenazine biosynthesis protein, phzf family
H4N61_RS11570	ENOG41090KN	UPF0303 protein
H4N61_RS11585	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
H4N61_RS11590	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
H4N61_RS11600	ENOG4105DHQ	Histidine kinase
H4N61_RS11630	ENOG4105KHC	sulfurtransferase
H4N61_RS11635	ENOG41066VF	YeeE YedE family protein
H4N61_RS11645	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
H4N61_RS11665	ENOG4108ZP8	Acetolactate synthase small subunit
H4N61_RS11670	ENOG4105C7K	acetolactate synthase
H4N61_RS11675	ENOG4105CJ3	phosphate transporter
H4N61_RS11705	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
H4N61_RS11710	ENOG4105EAC	phosphoserine phosphatase
H4N61_RS11715	ENOG4105EPW	hflc protein
H4N61_RS11720	ENOG4107QJR	hflk protein
H4N61_RS11745	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
H4N61_RS11795	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
H4N61_RS11800	ENOG4105DC7	peptidase M24
H4N61_RS11805	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
H4N61_RS11815	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4N61_RS11820	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
H4N61_RS11825	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
H4N61_RS11830	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
H4N61_RS11835	ENOG4108UFP	Essential cell division protein (By similarity)
H4N61_RS11840	ENOG4105CPF	Cell wall formation (By similarity)
H4N61_RS11845	ENOG4105DFU	Cell wall formation (By similarity)
H4N61_RS11850	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
H4N61_RS11860	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
H4N61_RS11865	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
H4N61_RS11870	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
H4N61_RS11885	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
H4N61_RS11895	ENOG4108UXN	response regulator
H4N61_RS11900	ENOG4105RAK	Histidine kinase
H4N61_RS11910	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
H4N61_RS11920	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
H4N61_RS11930	ENOG4105SYT	Methylenetetrahydrofolate reductase
H4N61_RS11935	ENOG4105KBH	arsR family transcriptional regulator
H4N61_RS11940	ENOG4105CUY	Mechanosensitive ion channel
H4N61_RS11955	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
H4N61_RS11970	ENOG4105C5Q	Transcriptional regulator
H4N61_RS11975	ENOG4105FR1	rard protein
H4N61_RS11990	ENOG4105D74	hydrolase
H4N61_RS12010	ENOG4105C5H	ABC transporter
H4N61_RS12030	ENOG4106TD9	Diguanylate cyclase
H4N61_RS12050	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
H4N61_RS12055	ENOG4108YZ9	Urea amidohydrolase subunit gamma
H4N61_RS12065	ENOG4105KI2	Urea amidohydrolase subunit beta
H4N61_RS12075	ENOG4105CQM	Urea amidohydrolase subunit alpha
H4N61_RS12085	ENOG41069B0	Membrane-bound lysozyme-inhibitor of c-type lysozyme
H4N61_RS12100	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
H4N61_RS12105	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
H4N61_RS12115	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
H4N61_RS12130	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
H4N61_RS12135	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
H4N61_RS12140	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
H4N61_RS12145	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
H4N61_RS12150	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
H4N61_RS12155	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
H4N61_RS12160	ENOG4105DU0	nucleoside hydrolase
H4N61_RS12165	ENOG4105C5H	ABC transporter
H4N61_RS12170	ENOG410829K	Lysine exporter protein (Lyse ygga)
H4N61_RS12205	ENOG4105BZU	Histidine kinase
H4N61_RS12210	ENOG4105BZU	Histidine kinase
H4N61_RS12215	ENOG4105D65	subunit l
H4N61_RS12220	ENOG4108ZE9	Monovalent cation H antiporter subunit C
H4N61_RS12225	ENOG4107R4Z	monovalent cation h antiporter subunit d
H4N61_RS12230	ENOG4105SC1	monovalent cation H antiporter subunit E
H4N61_RS12235	ENOG4105W4C	monovalent cation H antiporter subunit F
H4N61_RS12240	ENOG4105KJM	monovalent cation h antiporter subunit g
H4N61_RS12245	ENOG4105YB8	TM2 domain containing protein
H4N61_RS12250	ENOG4107HP6	Transcriptional regulator
H4N61_RS12255	ENOG4105PWN	phosphate abc transporter
H4N61_RS12260	ENOG4105C8U	phosphate abc transporter
H4N61_RS12270	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS12275	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
H4N61_RS12280	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
H4N61_RS12300	ENOG4105C26	Dehydrogenase
H4N61_RS12315	ENOG4105HF0	Membrane
H4N61_RS12325	ENOG4105CDV	Ompa motb domain protein
H4N61_RS12330	ENOG4108TEB	UPF0114 protein
H4N61_RS12375	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
H4N61_RS12380	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
H4N61_RS12390	ENOG4105F27	Major Facilitator
H4N61_RS12395	ENOG4105BZU	Histidine kinase
H4N61_RS12405	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
H4N61_RS12415	ENOG4105CGZ	zinc metallopeptidase
H4N61_RS12420	ENOG4105DEI	Mannitol dehydrogenase
H4N61_RS12425	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
H4N61_RS12435	ENOG4108R8Z	these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
H4N61_RS12445	ENOG4105CGH	5'-nucleotidase
H4N61_RS12450	ENOG4105K56	Transcriptional regulator
H4N61_RS12455	ENOG4108ZHJ	Organic hydroperoxide resistance protein
H4N61_RS12460	ENOG4105ER2	Ompa motb domain protein
H4N61_RS12465	ENOG4107RD7	Flagellar Motor Protein, MotA
H4N61_RS12470	ENOG4105CYM	Glutathione S-transferase
H4N61_RS12475	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
H4N61_RS12480	ENOG4105VDW	Csbd family
H4N61_RS12490	ENOG4105D8V	Glucose sorbosone dehydrogenase
H4N61_RS12550	ENOG41090JN	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
H4N61_RS12560	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
H4N61_RS12565	ENOG4105C3M	thioredoxin reductase
H4N61_RS12570	ENOG4105CBN	LysR family transcriptional regulator
H4N61_RS12600	ENOG4105C9B	Cysteine desulfurase
H4N61_RS12605	ENOG4107RT3	EamA-like transporter family
H4N61_RS12620	ENOG4107104	thymidine kinase
H4N61_RS12625	ENOG4105NAU	thioesterase Superfamily protein
H4N61_RS12665	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
H4N61_RS12720	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
H4N61_RS12740	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
H4N61_RS12745	ENOG4105D7X	high-affinity nickel-transporter
H4N61_RS12750	ENOG4105CC0	LysR family Transcriptional regulator
H4N61_RS12780	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
H4N61_RS12785	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
H4N61_RS12790	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
H4N61_RS12800	ENOG4108ZAF	Molybdopterin
H4N61_RS12805	ENOG4105CM2	brancheD-chain amino acid aminotransferase
H4N61_RS12810	ENOG41090HR	transcriptional regulator
H4N61_RS12815	ENOG4105II7	pyrroline-5-carboxylate reductase
H4N61_RS12830	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
H4N61_RS12840	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
H4N61_RS12845	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
H4N61_RS12860	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
H4N61_RS12865	ENOG4105F8D	glycoside hydrolase family 4
H4N61_RS12875	ENOG4105C3G	gtp-binding protein
H4N61_RS12895	ENOG4105DU1	integral membrane protein, terc
H4N61_RS12910	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
H4N61_RS12920	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
H4N61_RS12925	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
H4N61_RS12930	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
H4N61_RS12935	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
H4N61_RS12940	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
H4N61_RS12955	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
H4N61_RS12970	ENOG4105CHF	Glutathione S-transferase
H4N61_RS13000	ENOG4108YXU	transcriptional regulator AsnC family
H4N61_RS13010	ENOG4108J59	Extracellular solute-binding protein, family 5
H4N61_RS13015	ENOG4108JQ6	ABC transporter
H4N61_RS13020	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS13025	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS13030	ENOG4107791	aminotransferase class V
H4N61_RS13045	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
H4N61_RS13065	ENOG4105CPN	adenine deaminase
H4N61_RS13080	ENOG4107QUY	Guanine deaminase
H4N61_RS13100	ENOG4105UIB	(ABC) transporter
H4N61_RS13105	ENOG4108JQ9	ABC transporter
H4N61_RS13145	ENOG4105S0E	allantoin catabolism protein
H4N61_RS13150	ENOG4108Z2U	ureidoglycolate hydrolase
H4N61_RS13160	ENOG4108K4C	ec 3.1.3.12
H4N61_RS13170	ENOG4105C1J	atp-dependent rna helicase
H4N61_RS13180	ENOG4105EQW	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
H4N61_RS13205	ENOG4105CGH	5'-nucleotidase
H4N61_RS13225	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS13240	ENOG4107T3P	ABC, transporter
H4N61_RS13245	ENOG4105FKQ	transcriptional regulator
H4N61_RS13250	ENOG4105KHC	sulfurtransferase
H4N61_RS13260	ENOG4105BZS	acriflavin resistance protein
H4N61_RS13285	ENOG4108HWW	ABC transporter
H4N61_RS13290	ENOG4105C2J	ABC transporter
H4N61_RS13295	ENOG4105DFW	ABC transporter
H4N61_RS13305	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
H4N61_RS13330	ENOG4105CBD	Diacylglycerol kinase
H4N61_RS13335	ENOG4105RAK	Histidine kinase
H4N61_RS13350	ENOG41074H6	response regulator
H4N61_RS13375	ENOG4105GBT	ABC transporter
H4N61_RS13380	ENOG4106YG3	ABC transporter
H4N61_RS13395	ENOG4105EN6	Membrane
H4N61_RS13405	ENOG4105CHR	reductase
H4N61_RS13415	ENOG4107YCY	Transcriptional regulator
H4N61_RS13420	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
H4N61_RS13430	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
H4N61_RS13435	ENOG4107QN2	dihydrolipoyl dehydrogenase
H4N61_RS13440	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
H4N61_RS13455	ENOG4105C7S	Dehydrogenase
H4N61_RS13460	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
H4N61_RS13465	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
H4N61_RS13470	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
H4N61_RS13475	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
H4N61_RS13480	ENOG4105D6Z	AFG1 family ATPase
H4N61_RS13495	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
H4N61_RS13500	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
H4N61_RS13505	ENOG4108JQ5	ABC transporter
H4N61_RS13555	ENOG4105CFU	surface antigen
H4N61_RS13560	ENOG4105EMU	Dehydrogenase
H4N61_RS13580	ENOG4105RKW	reductase (By
H4N61_RS13585	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
H4N61_RS13590	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
H4N61_RS13605	ENOG4105I82	acetyl xylan esterase
H4N61_RS13625	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
H4N61_RS13630	ENOG41088YA	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity)
H4N61_RS13640	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
H4N61_RS13645	ENOG4105E0A	ABC, transporter
H4N61_RS13655	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
H4N61_RS13675	ENOG4105QNF	Outer membrane lipoprotein
H4N61_RS13685	ENOG4105D5G	Transposase
H4N61_RS13695	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
H4N61_RS13710	ENOG4105JNK	Glycosyl transferase (Group 1
H4N61_RS13720	ENOG4105E2K	Glycosyl transferase (Group 1
H4N61_RS13730	ENOG4107QPH	glycogen) synthase
H4N61_RS13740	ENOG4107QRS	glycosyltransferase group 2 family protein
H4N61_RS13750	ENOG4105DFG	type I secretion outer membrane protein
H4N61_RS13755	ENOG4108JJA	ABC, transporter
H4N61_RS13805	ENOG4105BZU	Histidine kinase
H4N61_RS13820	ENOG4105KK3	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
H4N61_RS13825	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
H4N61_RS13830	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
H4N61_RS13835	ENOG4105C8Q	Methyl-accepting chemotaxis
H4N61_RS13840	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
H4N61_RS13845	ENOG4105E0X	reductase
H4N61_RS13875	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
H4N61_RS13885	ENOG4108ZZF	transport protein (ExbD)
H4N61_RS13890	ENOG4105E02	MotA TolQ exbB proton channel
H4N61_RS13895	ENOG4107YD3	Thioesterase
H4N61_RS13905	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
H4N61_RS13915	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
H4N61_RS13920	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
H4N61_RS13925	ENOG4105BZU	Histidine kinase
H4N61_RS13930	ENOG4105CDY	transcriptional regulatory protein
H4N61_RS13940	ENOG4105D48	metallophosphoesterase
H4N61_RS13945	ENOG41080UU	5-formyltetrahydrofolate cyclo-ligase
H4N61_RS13985	ENOG4105CV8	reductase
H4N61_RS13990	ENOG4107R1Y	fructose-bisphosphate aldolase
H4N61_RS14005	ENOG4105ECY	inositol monophosphatase
H4N61_RS14015	ENOG4106VK6	Flagellar motor protein
H4N61_RS14020	ENOG4105KCK	Peptidoglycan-associated lipoprotein
H4N61_RS14030	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
H4N61_RS14035	ENOG4105CAS	nag kinase
H4N61_RS14040	ENOG4105C7B	Threonine dehydratase
H4N61_RS14065	ENOG4105KTU	Transcriptional regulator, arsr family
H4N61_RS14070	ENOG4105PGM	cation diffusion facilitator family transporter
H4N61_RS14080	ENOG4108IJ6	ABC transporter
H4N61_RS14090	ENOG4108I5D	sulfate abc transporter
H4N61_RS14110	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
H4N61_RS14115	ENOG4105C6K	Malic enzyme
H4N61_RS14125	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
H4N61_RS14135	ENOG4108JQ6	ABC transporter
H4N61_RS14140	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS14145	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS14150	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
H4N61_RS14155	ENOG4106KNT	transcriptional regulator
H4N61_RS14160	ENOG4107S8C	mandelate racemase muconate lactonizing
H4N61_RS14170	ENOG4105BZU	Histidine kinase
H4N61_RS14175	ENOG4105EMN	RNA polymerase sigma factor
H4N61_RS14180	ENOG4105I03	Flagellin
H4N61_RS14200	ENOG410822I	Flagellar hook capping protein
H4N61_RS14205	ENOG4105BZE	flagellar hook protein, FlgE
H4N61_RS14235	ENOG41073TP	transcriptional regulator
H4N61_RS14240	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS14245	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS14255	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
H4N61_RS14260	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
H4N61_RS14285	ENOG4105C5I	Dehydrogenase
H4N61_RS14290	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS14295	ENOG4105NRK	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS14300	ENOG4105D81	ABC transporter, permease
H4N61_RS14310	ENOG4105VQD	rieske 2fe-2S domain-containing protein
H4N61_RS14315	ENOG4105VQD	rieske 2fe-2S domain-containing protein
H4N61_RS14335	ENOG4105CQB	FAD linked oxidase domain protein
H4N61_RS14340	ENOG41073TP	transcriptional regulator
H4N61_RS14345	ENOG4107R73	Mate efflux family protein
H4N61_RS14355	ENOG4105CNN	ABC, transporter
H4N61_RS14360	ENOG4105C2J	ABC transporter
H4N61_RS14370	ENOG4105CMG	Carbohydrate kinase
H4N61_RS14375	ENOG4105HFZ	Membrane
H4N61_RS14380	ENOG4108TPP	exopolysaccharide synthesis
H4N61_RS14395	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
H4N61_RS14460	ENOG4105CP2	von willebrand factor, type a
H4N61_RS14475	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
H4N61_RS14495	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
H4N61_RS14500	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
H4N61_RS14510	ENOG4105DD5	Flagellar motor switch protein
H4N61_RS14515	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
H4N61_RS14520	ENOG4105D7B	Flagellar biosynthesis protein flha
H4N61_RS14545	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
H4N61_RS14595	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
H4N61_RS14600	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
H4N61_RS14615	ENOG4107U9T	Pfam:Ribonuclease_BN
H4N61_RS14630	ENOG4108PCN	EamA-like transporter family
H4N61_RS14635	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
H4N61_RS14650	ENOG4106SMU	thiamine transporter membrane protein
H4N61_RS14655	ENOG4105DP9	ABC transporter
H4N61_RS14665	ENOG4105BZ1	(ABC) transporter
H4N61_RS14670	ENOG41082FS	50S ribosomal protein L31
H4N61_RS14675	ENOG4105KK4	UPF0060 membrane protein
H4N61_RS14710	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
H4N61_RS14715	ENOG4105W8H	transhydrogenase (subunit alpha
H4N61_RS14720	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
H4N61_RS14725	ENOG41069P5	Protein slyX homolog
H4N61_RS14745	ENOG4105C2C	drug resistance transporter, Bcr CflA
H4N61_RS14750	ENOG4105K5G	30S ribosomal protein S21
H4N61_RS14755	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
H4N61_RS14760	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
H4N61_RS14780	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
H4N61_RS14790	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
H4N61_RS14820	ENOG4105UT3	Methyl-accepting chemotaxis
H4N61_RS14830	ENOG4105Y2X	UPF0335 protein
H4N61_RS14840	ENOG4105CA9	Pyruvate kinase
H4N61_RS14855	ENOG4105YK5	50S ribosomal protein L36
H4N61_RS14860	ENOG4108JQ7	(ABC) transporter
H4N61_RS14865	ENOG4105C3U	ABC transporter
H4N61_RS14870	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS14875	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
H4N61_RS14880	ENOG4107QSI	ABC, transporter
H4N61_RS14885	ENOG4105CHU	acetyl-coa acetyltransferase
H4N61_RS14890	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
H4N61_RS14895	ENOG4107QPN	acyl-Coa dehydrogenase
H4N61_RS14900	ENOG4105CEY	Amp-dependent synthetase and ligase
H4N61_RS14905	ENOG4108Z6Z	Transcriptional regulator
H4N61_RS14910	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
H4N61_RS14915	ENOG4107RYT	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
H4N61_RS14960	ENOG4107SET	aldo keto reductase
H4N61_RS14965	ENOG4107XBN	GntR Family Transcriptional Regulator
H4N61_RS14970	ENOG4105DDC	Oxidoreductase domain protein
H4N61_RS14980	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
H4N61_RS14985	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
H4N61_RS15000	ENOG4105CQ7	ATP-dependent helicase
H4N61_RS15005	ENOG4105Z4Q	MltA-interacting MipA family protein
H4N61_RS15010	ENOG4105E0X	reductase
H4N61_RS15020	ENOG4105CQZ	Histidine kinase
H4N61_RS15080	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
H4N61_RS15095	ENOG4108ZNX	Heat shock protein
H4N61_RS15100	ENOG4105CTX	dehydratase
H4N61_RS15105	ENOG4107XBN	GntR Family Transcriptional Regulator
H4N61_RS15110	ENOG4105NWF	RbsD or FucU transport
H4N61_RS15115	ENOG4105ERH	Fumarylacetoacetate hydrolase
H4N61_RS15120	ENOG4105D7K	pfkb domain protein
H4N61_RS15125	ENOG4105C5H	ABC transporter
H4N61_RS15135	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
H4N61_RS15140	ENOG4105CAT	Cytidine monophosphate kinase
H4N61_RS15150	ENOG4105KDM	Diguanylate cyclase with gaf sensor
H4N61_RS15155	ENOG4105CH5	extracellular solute-binding protein, family 7
H4N61_RS15165	ENOG4105DMF	Dehydrogenase
H4N61_RS15170	ENOG4105E0C	molybdate abc transporter
H4N61_RS15175	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
H4N61_RS15180	ENOG4105F4R	Transcriptional regulator mode
H4N61_RS15220	ENOG4108KHX	Diguanylate cyclase
H4N61_RS15235	ENOG4105CPC	Aldo Keto reductase
H4N61_RS15265	ENOG4105CVE	Lytic murein transglycosylase
H4N61_RS15270	ENOG4105D8X	mechanosensitive ion channel
H4N61_RS15305	ENOG4105DR5	peptidase
H4N61_RS15315	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
H4N61_RS15325	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
H4N61_RS15330	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
H4N61_RS15335	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
H4N61_RS15340	ENOG4105CFH	Aspartokinase
H4N61_RS15345	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
H4N61_RS15360	ENOG4105C37	(CBS) domain
H4N61_RS15365	ENOG4105C01	Dihydroxy-acid dehydratase
H4N61_RS15385	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
H4N61_RS15390	ENOG4105D60	lipoprotein releasing system transmembrane protein
H4N61_RS15395	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
H4N61_RS15410	ENOG4105VW4	glutaredoxin 3
H4N61_RS15415	ENOG41081UC	Inherit from COG: Competence protein
H4N61_RS15425	ENOG4108VJ1	Transcriptional regulator (CarD family
H4N61_RS15430	ENOG4108Z4U	Ferredoxin
H4N61_RS15455	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
H4N61_RS15490	ENOG4108RYK	Nad-dependent epimerase dehydratase
H4N61_RS15495	ENOG4105KVH	Transcriptional regulator
H4N61_RS15500	ENOG4105BZU	Histidine kinase
H4N61_RS15515	ENOG4105KDC	50s ribosomal protein l28
H4N61_RS15545	ENOG4105M85	Bola protein
H4N61_RS15550	ENOG4105D49	3-dehydroquinate synthase
H4N61_RS15555	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
H4N61_RS15565	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
H4N61_RS15570	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
H4N61_RS15575	ENOG4105F7V	ErfK ybiS ycfS ynhG family protein
H4N61_RS15585	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
H4N61_RS15590	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
H4N61_RS15595	ENOG4108JGH	Tetr family transcriptional regulator
H4N61_RS15605	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
H4N61_RS15610	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
H4N61_RS15615	ENOG4105M6F	mutator MutT protein
H4N61_RS15625	ENOG4105ERG	peptidase m48, ste24p
H4N61_RS15635	ENOG41080I0	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
H4N61_RS15655	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
H4N61_RS15675	ENOG4108WBT	adenosyltransferase
H4N61_RS15690	ENOG4107ZT5	Thiol disulfide interchange protein
H4N61_RS15695	ENOG4105CH7	arginosuccinase
H4N61_RS15705	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
H4N61_RS15710	ENOG4105CBS	Chea signal transduction histidine kinase
H4N61_RS15725	ENOG4105CAK	Cell division ATP-binding protein ftsE
H4N61_RS15745	ENOG4108NH8	Cation transport protein
H4N61_RS15760	ENOG4105CIH	Imidazole acetol-phosphate transaminase
H4N61_RS15770	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
H4N61_RS15795	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
H4N61_RS15820	ENOG4105C9Q	fumarate hydratase class II
H4N61_RS15825	ENOG41082R8	50S ribosomal protein l32
H4N61_RS15850	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
H4N61_RS15860	ENOG4108K3A	Glutathione S-transferase
H4N61_RS15865	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
H4N61_RS15880	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
H4N61_RS15910	ENOG4105C32	Amino acid ABC transporter (Permease)
H4N61_RS15915	ENOG4108IV0	ABC, transporter
H4N61_RS15920	ENOG4105C0Z	ABC transporter
H4N61_RS15925	ENOG4108Z5K	methylglyoxal synthase
H4N61_RS15930	ENOG4105C8Q	Methyl-accepting chemotaxis
H4N61_RS15935	ENOG4107SDU	Methyl-accepting chemotaxis
H4N61_RS15945	ENOG4105C8Q	Methyl-accepting chemotaxis
H4N61_RS15960	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
H4N61_RS15965	ENOG4105BZU	Histidine kinase
H4N61_RS15970	ENOG4105C8Q	Methyl-accepting chemotaxis
H4N61_RS15985	ENOG4108V3W	Chemotaxis protein, CheW
H4N61_RS15990	ENOG4105CBS	Chea signal transduction histidine kinase
H4N61_RS15995	ENOG4108VYJ	response regulator receiver protein
H4N61_RS16020	ENOG4107UH8	sugar kinase
H4N61_RS16025	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
H4N61_RS16030	ENOG4107RUE	extracellular solute-binding protein family 1
H4N61_RS16035	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS16040	ENOG4105F38	ABC transporter, permease
H4N61_RS16045	ENOG4105D38	putrescine abc transporter
H4N61_RS16055	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
H4N61_RS16060	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
H4N61_RS16075	ENOG4105CPC	Aldo Keto reductase
H4N61_RS16085	ENOG4105D4P	Coproporphyrinogen iii oxidase
H4N61_RS16095	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
H4N61_RS16100	ENOG4105BZU	Histidine kinase
H4N61_RS16105	ENOG4108V3W	Chemotaxis protein, CheW
H4N61_RS16110	ENOG4105C8Q	Methyl-accepting chemotaxis
H4N61_RS16115	ENOG410807Z	Modulation of CheA activity in response to attractants (Chemotaxis
H4N61_RS16120	ENOG4105CBS	Chea signal transduction histidine kinase
H4N61_RS16145	ENOG4108RVA	ribokinase
H4N61_RS16155	ENOG4105DZG	Dehydrogenase
H4N61_RS16160	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
H4N61_RS16170	ENOG4108N8X	transition metal ion binding
H4N61_RS16175	ENOG410903D	sensor protein
H4N61_RS16205	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
H4N61_RS16215	ENOG4105FDF	Could be involved in DNA repair (By similarity)
H4N61_RS16220	ENOG4105DQE	DNA ligase
H4N61_RS16225	ENOG4105BZU	Histidine kinase
H4N61_RS16235	ENOG4105BZU	Histidine kinase
H4N61_RS16325	ENOG4108Z9Z	response to DNA damage stimulus
H4N61_RS16340	ENOG4105E2V	Glycosyltransferase 36
H4N61_RS16355	ENOG4105CMM	transposase
H4N61_RS16385	ENOG4105DRR	Transcriptional regulator, GntR family
H4N61_RS16390	ENOG4107258	Transcriptional regulator
H4N61_RS16395	ENOG4107QM5	aconitate hydratase
H4N61_RS16420	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
H4N61_RS16460	ENOG4105K46	50S ribosomal protein l27
H4N61_RS16480	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H4N61_RS16495	ENOG4107WK2	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
H4N61_RS16505	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
H4N61_RS16515	ENOG4105CN1	protease
H4N61_RS16525	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
H4N61_RS16535	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
H4N61_RS16540	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
H4N61_RS16545	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
H4N61_RS16555	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
H4N61_RS16560	ENOG4105C25	Primosomal protein n'
H4N61_RS16570	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
H4N61_RS16575	ENOG4105SX7	Transporter
H4N61_RS16585	ENOG4105E33	succinate dehydrogenase
H4N61_RS16600	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
H4N61_RS16615	ENOG4105C8Q	Methyl-accepting chemotaxis
H4N61_RS16625	ENOG4107B2H	carbonic anhydrase
H4N61_RS16640	ENOG4108594	Permease of the drug metabolite transporter
H4N61_RS16645	ENOG4108594	Permease of the drug metabolite transporter
H4N61_RS16650	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
H4N61_RS16655	ENOG4105CBX	hi0933 family
H4N61_RS16665	ENOG4105DEN	Luciferase family
H4N61_RS16685	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
H4N61_RS16690	ENOG4107EJG	GntR family transcriptional regulator
H4N61_RS16700	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
H4N61_RS16705	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
H4N61_RS16725	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
H4N61_RS16740	ENOG4105DC1	bifunctional purine biosynthesis protein purh
H4N61_RS16750	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
H4N61_RS16755	ENOG4105D0M	Protease HtpX homolog
H4N61_RS16770	ENOG4107QX9	Thiol disulfide interChange protein
H4N61_RS16780	ENOG41060IM	Heme exporter protein
H4N61_RS16785	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
H4N61_RS16790	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS16795	ENOG4107QM5	aconitate hydratase
H4N61_RS16820	ENOG4105HFZ	Membrane
H4N61_RS16840	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
H4N61_RS16845	ENOG4105D6S	protein involved in catabolism of external DNA
H4N61_RS16865	ENOG4105CI3	gtp-binding protein typa
H4N61_RS16870	ENOG4107T5V	SNARE associated Golgi
H4N61_RS16880	ENOG410856B	UPF0235 protein
H4N61_RS16885	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H4N61_RS16915	ENOG4105C5I	Dehydrogenase
H4N61_RS16925	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
H4N61_RS16930	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
H4N61_RS16940	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
H4N61_RS16945	ENOG4105DVC	DnaJ domain protein
H4N61_RS17020	ENOG4107MII	Sugar-specific transcriptional regulator TrmB
H4N61_RS17025	ENOG4105CPW	cytochrome b561
H4N61_RS17035	ENOG4105F0N	pyrophosphate phospho-hydrolase
H4N61_RS17040	ENOG41068KF	Universal stress protein
H4N61_RS17060	ENOG4105C0B	DNA polymerase III (alpha subunit)
H4N61_RS17065	ENOG4105KZX	Pterin carbinolamine dehydratase
H4N61_RS17100	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
H4N61_RS17110	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
H4N61_RS17125	ENOG4107835	probably involved in intracellular septation (By similarity)
H4N61_RS17130	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
H4N61_RS17135	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
H4N61_RS17140	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
H4N61_RS17160	ENOG4105K5M	30s ribosomal protein S16
H4N61_RS17170	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
H4N61_RS17180	ENOG4108176	endoribonuclease L-psp
H4N61_RS17190	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
H4N61_RS17195	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
H4N61_RS17200	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
H4N61_RS17205	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
H4N61_RS17220	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
H4N61_RS17225	ENOG4105DFA	alanine racemase domain protein
H4N61_RS17230	ENOG4105C8T	Leucyl-tRNA synthetase
H4N61_RS17250	ENOG4107YTN	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity)
H4N61_RS17255	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
H4N61_RS17260	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
H4N61_RS17265	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
H4N61_RS17270	ENOG4108YXA	Membrane
H4N61_RS17275	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
H4N61_RS17280	ENOG4108UHJ	MAF-like protein
H4N61_RS17285	ENOG4105E2X	shikimate dehydrogenase
H4N61_RS17290	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
H4N61_RS17300	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
H4N61_RS17305	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
H4N61_RS17315	ENOG4108DG9	Smr protein MutS2
H4N61_RS17325	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
H4N61_RS17330	ENOG4108MK9	spermidine N(1)-acetyltransferase
H4N61_RS17335	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
H4N61_RS17340	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
H4N61_RS17345	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
H4N61_RS17350	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
H4N61_RS17360	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
H4N61_RS17365	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
H4N61_RS17370	ENOG4105CS9	pantothenic acid kinase
H4N61_RS17385	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
H4N61_RS17390	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
H4N61_RS17400	ENOG4105CSM	endonuclease III
H4N61_RS17405	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
H4N61_RS17410	ENOG4105D7K	pfkb domain protein
H4N61_RS17415	ENOG4107TFQ	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
H4N61_RS17420	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
H4N61_RS17440	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
H4N61_RS17445	ENOG4105CFG	Acts as a chaperone (By similarity)
H4N61_RS17460	ENOG4108RWI	nicotinamidase
H4N61_RS17470	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H4N61_RS17480	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
H4N61_RS17485	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
H4N61_RS17490	ENOG4105CSA	Coproporphyrinogen iii oxidase
H4N61_RS17495	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
H4N61_RS17500	ENOG41082FP	UPF0102 protein
H4N61_RS17510	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
H4N61_RS17545	ENOG4107QX8	SPFH domain, Band 7 family protein
H4N61_RS17550	ENOG4108UQ1	hydrolase, family 25
H4N61_RS17580	ENOG4105D29	Helix-turn-helix type 11 domain protein
H4N61_RS17590	ENOG4105ETE	Transcriptional regulator (LacI family
H4N61_RS17595	ENOG4105CMG	Carbohydrate kinase
H4N61_RS17600	ENOG4105C93	Xylose Isomerase
H4N61_RS17610	ENOG4105DSG	hydrolase family 43
H4N61_RS17625	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
H4N61_RS17630	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
H4N61_RS17640	ENOG4105C31	Tryptophanyl-tRNA synthetase
H4N61_RS17655	ENOG41083MR	nifu domain-containing protein
H4N61_RS17660	ENOG4107QS4	23S rRNA
H4N61_RS17710	ENOG4105NTW	Transcriptional regulator
H4N61_RS17735	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
H4N61_RS17745	ENOG4105WXW	Antirepressor
H4N61_RS17750	ENOG4108C33	Resolvase
H4N61_RS17760	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
H4N61_RS17765	ENOG41072GX	Peptidase M22 Glycoprotease
H4N61_RS17775	ENOG41090R7	Ferric uptake
H4N61_RS17790	ENOG4107RH7	Nicotinate phosphoribosyltransferase
H4N61_RS17810	ENOG4105CAT	Cytidine monophosphate kinase
H4N61_RS17815	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
H4N61_RS17825	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
H4N61_RS17835	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
H4N61_RS17845	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
H4N61_RS17850	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
H4N61_RS17855	ENOG4108S0S	Nucleotidyl transferase
H4N61_RS17865	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
H4N61_RS17875	ENOG4105D17	glycoside hydrolase, family 3 domain protein
H4N61_RS17880	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
H4N61_RS17885	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
H4N61_RS17890	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
H4N61_RS17895	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
H4N61_RS17925	ENOG4108ZNX	Heat shock protein
H4N61_RS17935	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
H4N61_RS17940	ENOG4107TNS	sigma 54 modulation protein ribosomal protein S30ea
H4N61_RS17945	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
H4N61_RS17950	ENOG4108IUZ	ABC transporter
H4N61_RS17965	ENOG4107U9H	DNA polymerase
H4N61_RS17970	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
H4N61_RS17975	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
H4N61_RS17980	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
H4N61_RS17995	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
H4N61_RS18005	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
H4N61_RS18020	ENOG410903D	sensor protein
H4N61_RS18025	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
H4N61_RS18030	ENOG4105C9A	Phoh family
H4N61_RS18035	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
H4N61_RS18040	ENOG4107RCQ	(CBS) domain
H4N61_RS18045	ENOG4105CQB	FAD linked oxidase domain protein
H4N61_RS18060	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
H4N61_RS18065	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
H4N61_RS18080	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
H4N61_RS18110	ENOG4105W49	UPF0434 protein
H4N61_RS18120	ENOG4108YZA	Nitrogen regulatory protein pii
H4N61_RS18130	ENOG4108YZA	Nitrogen regulatory protein pii
H4N61_RS18135	ENOG4105BZU	Histidine kinase
H4N61_RS18155	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
H4N61_RS18165	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
H4N61_RS18185	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
H4N61_RS18195	ENOG4108MUX	N-hydroxyarylamine O-acetyltransferase
H4N61_RS18210	ENOG4108RVA	ribokinase
H4N61_RS18215	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
H4N61_RS18230	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
H4N61_RS18240	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
H4N61_RS18245	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
H4N61_RS18250	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
H4N61_RS18255	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)