locus-tag	class	description
H4N61_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H4N61_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H4N61_RS00025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4N61_RS00075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4N61_RS00080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4N61_RS00085	COG1121	(ABC) transporter
H4N61_RS00115	COG1442	glycosyl transferase family 8
H4N61_RS00155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4N61_RS00165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H4N61_RS00170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H4N61_RS00185	COG0738	Major facilitator superfamily
H4N61_RS00190	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H4N61_RS00195	COG0450	alkyl hydroperoxide reductase
H4N61_RS00205	COG0765	amino acid transport
H4N61_RS00215	COG0583	DNA-binding transcription factor activity
H4N61_RS00225	COG0481	GTPase activity
H4N61_RS00245	COG0667	Aldo Keto reductase
H4N61_RS00280	COG1999	signal sequence binding
H4N61_RS00285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4N61_RS00290	COG3422	double-strand break repair
H4N61_RS00305	COG0492	ferredoxin-NADP+ reductase activity
H4N61_RS00310	COG1959	2 iron, 2 sulfur cluster binding
H4N61_RS00330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4N61_RS00335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4N61_RS00340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4N61_RS00355	COG2852	Protein conserved in bacteria
H4N61_RS00375	COG1309	transcriptional regulator
H4N61_RS00395	COG1215	transferase activity, transferring glycosyl groups
H4N61_RS00430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4N61_RS00490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H4N61_RS00545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H4N61_RS00555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H4N61_RS00560	COG1349	DNA-binding transcription factor activity
H4N61_RS00575	COG0154	amidase activity
H4N61_RS00580	COG0747	negative chemotaxis
H4N61_RS00590	COG4608	Belongs to the ABC transporter superfamily
H4N61_RS00655	COG2943	transferase activity, transferring hexosyl groups
H4N61_RS00660	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H4N61_RS00685	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H4N61_RS00710	COG1609	Transcriptional regulator
H4N61_RS00720	COG1959	2 iron, 2 sulfur cluster binding
H4N61_RS00735	COG0667	Aldo Keto reductase
H4N61_RS00740	COG0747	negative chemotaxis
H4N61_RS00745	COG0601	transmembrane transport
H4N61_RS00750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4N61_RS00755	COG0444	Belongs to the ABC transporter superfamily
H4N61_RS00760	COG4608	Belongs to the ABC transporter superfamily
H4N61_RS00780	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4N61_RS00780	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4N61_RS00790	COG0642	Histidine kinase
H4N61_RS00795	COG0745	RESPONSE REGULATOR receiver
H4N61_RS00800	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H4N61_RS00825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H4N61_RS00835	COG2079	MmgE PrpD family protein
H4N61_RS00845	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H4N61_RS00855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H4N61_RS00865	COG2205	protein histidine kinase activity
H4N61_RS00870	COG0802	atpase or kinase
H4N61_RS00880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4N61_RS00880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4N61_RS00885	COG0745	RESPONSE REGULATOR receiver
H4N61_RS00895	COG1047	Peptidyl-prolyl cis-trans
H4N61_RS00900	COG2818	Glycosylase
H4N61_RS00935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4N61_RS00980	COG2244	polysaccharide biosynthetic process
H4N61_RS00985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H4N61_RS00995	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H4N61_RS01000	COG1088	dTDP-glucose 4,6-dehydratase activity
H4N61_RS01045	COG3842	ATPase activity
H4N61_RS01055	COG2186	Transcriptional regulator
H4N61_RS01065	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4N61_RS01075	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS01080	COG4948	Mandelate Racemase Muconate Lactonizing
H4N61_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS01090	COG0251	oxidation-reduction process
H4N61_RS01100	COG1215	transferase activity, transferring glycosyl groups
H4N61_RS01130	COG3447	MASE1 domain protein
H4N61_RS01130	COG5002	protein histidine kinase activity
H4N61_RS01130	COG5001	Diguanylate cyclase
H4N61_RS01135	COG4604	ABC transporter, ATP-binding protein
H4N61_RS01140	COG4605	iron ion homeostasis
H4N61_RS01145	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4N61_RS01165	COG1132	(ABC) transporter
H4N61_RS01170	COG1132	(ABC) transporter
H4N61_RS01180	COG0514	ATP-dependent DNA helicase (RecQ)
H4N61_RS01185	COG2094	Belongs to the DNA glycosylase MPG family
H4N61_RS01195	COG2514	catechol 2,3-dioxygenase activity
H4N61_RS01205	COG1132	(ABC) transporter
H4N61_RS01215	COG2326	polyphosphate kinase activity
H4N61_RS01220	COG5002	protein histidine kinase activity
H4N61_RS01230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4N61_RS01235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H4N61_RS01245	COG2197	response regulator
H4N61_RS01255	COG0477	Major facilitator Superfamily
H4N61_RS01260	COG1396	sequence-specific DNA binding
H4N61_RS01260	COG3800	Transcriptional regulator
H4N61_RS01270	COG2224	Isocitrate lyase
H4N61_RS01280	COG3300	MHYT domain
H4N61_RS01280	COG5001	Diguanylate cyclase
H4N61_RS01285	COG0717	Belongs to the dCTP deaminase family
H4N61_RS01295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4N61_RS01305	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H4N61_RS01320	COG0167	dihydroorotate dehydrogenase activity
H4N61_RS01345	COG1201	RNA secondary structure unwinding
H4N61_RS01370	COG0730	response to heat
H4N61_RS01430	COG0295	cytidine deaminase activity
H4N61_RS01435	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H4N61_RS01440	COG1012	belongs to the aldehyde dehydrogenase family
H4N61_RS01455	COG1566	PFAM secretion protein HlyD family protein
H4N61_RS01465	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H4N61_RS01470	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H4N61_RS01475	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H4N61_RS01480	COG0346	lactoylglutathione lyase activity
H4N61_RS01525	COG4964	Belongs to the GSP D family
H4N61_RS01545	COG4964	Belongs to the GSP D family
H4N61_RS01575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H4N61_RS01590	COG3474	cytochrome
H4N61_RS01595	COG0077	Prephenate dehydratase
H4N61_RS01595	COG1605	Chorismate mutase
H4N61_RS01600	COG2171	N-acyltransferase activity
H4N61_RS01610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4N61_RS01625	COG0101	tRNA pseudouridine synthase activity
H4N61_RS01635	COG0242	peptide deformylase activity
H4N61_RS01640	COG1322	Protein conserved in bacteria
H4N61_RS01650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H4N61_RS01655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H4N61_RS01660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H4N61_RS01670	COG4529	Protein conserved in bacteria
H4N61_RS01675	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H4N61_RS01690	COG4993	Dehydrogenase
H4N61_RS01700	COG1970	mechanosensitive ion channel activity
H4N61_RS01710	COG2885	chlorophyll binding
H4N61_RS01720	COG0156	8-amino-7-oxononanoate synthase activity
H4N61_RS01730	COG4566	intracellular signal transduction
H4N61_RS01745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4N61_RS01775	COG2197	response regulator
H4N61_RS01790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4N61_RS01805	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H4N61_RS01810	COG5328	Belongs to the UPF0262 family
H4N61_RS01815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H4N61_RS01820	COG0424	maF-like protein
H4N61_RS01825	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H4N61_RS01830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4N61_RS01835	COG2261	transglycosylase associated protein
H4N61_RS01850	COG4251	negative regulation of phosphorylation
H4N61_RS01870	COG1904	glucuronate isomerase
H4N61_RS01885	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H4N61_RS01890	COG1999	signal sequence binding
H4N61_RS01895	COG1722	exodeoxyribonuclease VII activity
H4N61_RS01900	COG0123	including yeast histone deacetylase and acetoin utilization protein
H4N61_RS01905	COG0009	L-threonylcarbamoyladenylate synthase
H4N61_RS01940	COG0366	Alpha amylase catalytic
H4N61_RS01950	COG1473	amidohydrolase
H4N61_RS01955	COG2086	electron transfer activity
H4N61_RS01960	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H4N61_RS01970	COG0489	protein tyrosine kinase activity
H4N61_RS01975	COG2723	6-phospho-beta-galactosidase activity
H4N61_RS01980	COG4172	Belongs to the ABC transporter superfamily
H4N61_RS01985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4N61_RS02015	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H4N61_RS02030	COG0124	histidyl-tRNA synthetase
H4N61_RS02040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H4N61_RS02070	COG0459	protein refolding
H4N61_RS02075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H4N61_RS02090	COG0697	spore germination
H4N61_RS02100	COG2204	response regulator
H4N61_RS02115	COG0196	riboflavin kinase activity
H4N61_RS02125	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H4N61_RS02140	COG0742	ribosomal rna small subunit methyltransferase
H4N61_RS02155	COG0735	belongs to the Fur family
H4N61_RS02160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4N61_RS02165	COG1121	(ABC) transporter
H4N61_RS02195	COG2824	Alkylphosphonate utilization operon protein PhnA
H4N61_RS02215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H4N61_RS02230	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H4N61_RS02235	COG0363	glucosamine-6-phosphate deaminase activity
H4N61_RS02240	COG0129	dihydroxy-acid dehydratase activity
H4N61_RS02245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4N61_RS02260	COG0151	Belongs to the GarS family
H4N61_RS02265	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4N61_RS02275	COG0590	tRNA wobble adenosine to inosine editing
H4N61_RS02285	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H4N61_RS02290	COG0400	carboxylic ester hydrolase activity
H4N61_RS02295	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H4N61_RS02305	COG0483	inositol monophosphate 1-phosphatase activity
H4N61_RS02325	COG1570	exodeoxyribonuclease VII activity
H4N61_RS02330	COG0583	DNA-binding transcription factor activity
H4N61_RS02345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4N61_RS02350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4N61_RS02355	COG0109	protoheme IX farnesyltransferase activity
H4N61_RS02365	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H4N61_RS02385	COG0612	Peptidase, M16
H4N61_RS02390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4N61_RS02400	COG1678	Uncharacterized ACR, COG1678
H4N61_RS02410	COG0678	peroxiredoxin activity
H4N61_RS02410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H4N61_RS02420	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4N61_RS02425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4N61_RS02430	COG0509	glycine decarboxylation via glycine cleavage system
H4N61_RS02435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H4N61_RS02440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H4N61_RS02450	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H4N61_RS02455	COG0356	it plays a direct role in the translocation of protons across the membrane
H4N61_RS02465	COG1196	nuclear chromosome segregation
H4N61_RS02470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4N61_RS02490	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H4N61_RS02495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H4N61_RS02505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4N61_RS02515	COG2814	Major facilitator Superfamily
H4N61_RS02520	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4N61_RS02530	COG1573	uracil-dna glycosylase
H4N61_RS02545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H4N61_RS02550	COG0142	geranyltranstransferase activity
H4N61_RS02560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4N61_RS02560	COG0616	signal peptide processing
H4N61_RS02570	COG0752	glycyl-tRNA synthetase alpha subunit
H4N61_RS02575	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
H4N61_RS02585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4N61_RS02590	COG1704	LemA family
H4N61_RS02600	COG0751	glycine-tRNA ligase activity
H4N61_RS02605	COG2354	Protein conserved in bacteria
H4N61_RS02610	COG0328	RNA-DNA hybrid ribonuclease activity
H4N61_RS02620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H4N61_RS02625	COG0574	Belongs to the PEP-utilizing enzyme family
H4N61_RS02625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4N61_RS02635	COG3773	Cell wall hydrolase
H4N61_RS02635	COG3409	Peptidoglycan-binding domain 1 protein
H4N61_RS02645	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H4N61_RS02650	COG0354	folic acid binding
H4N61_RS02665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H4N61_RS02680	COG0494	nUDIX hydrolase
H4N61_RS02685	COG2135	peptidase activity
H4N61_RS02700	COG0277	FAD linked oxidase domain protein
H4N61_RS02710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H4N61_RS02765	COG4948	Mandelate Racemase Muconate Lactonizing
H4N61_RS02780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4N61_RS02820	COG4372	Transposase
H4N61_RS02825	COG3436	PFAM IS66 Orf2 family protein
H4N61_RS02855	COG0297	glycogen (starch) synthase activity
H4N61_RS02860	COG1484	DNA-dependent DNA replication
H4N61_RS02865	COG4584	PFAM Integrase catalytic
H4N61_RS02875	COG3328	transposase activity
H4N61_RS02880	COG2267	carboxylic ester hydrolase activity
H4N61_RS02915	COG1024	Enoyl-CoA hydratase
H4N61_RS02945	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS02960	COG2814	Major facilitator Superfamily
H4N61_RS02980	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4N61_RS02980	COG1024	Enoyl-CoA hydratase
H4N61_RS02985	COG0583	DNA-binding transcription factor activity
H4N61_RS02990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4N61_RS02995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4N61_RS03005	COG0583	DNA-binding transcription factor activity
H4N61_RS03040	COG1215	transferase activity, transferring glycosyl groups
H4N61_RS03065	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H4N61_RS03080	COG3328	transposase activity
H4N61_RS03085	COG0489	protein tyrosine kinase activity
H4N61_RS03085	COG3206	protein involved in exopolysaccharide biosynthesis
H4N61_RS03090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4N61_RS03115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4N61_RS03155	COG1802	Transcriptional regulator
H4N61_RS03160	COG3842	ATPase activity
H4N61_RS03165	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4N61_RS03170	COG1177	transmembrane transport
H4N61_RS03190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4N61_RS03200	COG1132	(ABC) transporter
H4N61_RS03205	COG0010	Belongs to the arginase family
H4N61_RS03210	COG1396	sequence-specific DNA binding
H4N61_RS03220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4N61_RS03230	COG4160	amino acid transport
H4N61_RS03250	COG1122	ATPase activity
H4N61_RS03260	COG1268	BioY protein
H4N61_RS03270	COG0584	glycerophosphoryl diester phosphodiesterase
H4N61_RS03275	COG3842	ATPase activity
H4N61_RS03280	COG0395	ABC-type sugar transport system, permease component
H4N61_RS03285	COG1175	transmembrane transport
H4N61_RS03290	COG1653	transport
H4N61_RS03295	COG1940	carbohydrate kinase activity
H4N61_RS03300	COG3142	Participates in the control of copper homeostasis
H4N61_RS03325	COG0395	ABC-type sugar transport system, permease component
H4N61_RS03340	COG1737	Transcriptional regulator
H4N61_RS03375	COG0444	Belongs to the ABC transporter superfamily
H4N61_RS03380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4N61_RS03405	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H4N61_RS03410	COG1737	Transcriptional regulator
H4N61_RS03425	COG1175	transmembrane transport
H4N61_RS03430	COG0395	ABC-type sugar transport system, permease component
H4N61_RS03435	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H4N61_RS03455	COG1522	sequence-specific DNA binding
H4N61_RS03475	COG0444	Belongs to the ABC transporter superfamily
H4N61_RS03485	COG0601	transmembrane transport
H4N61_RS03490	COG1396	sequence-specific DNA binding
H4N61_RS03505	COG0363	glucosamine-6-phosphate deaminase activity
H4N61_RS03515	COG1486	melibiose metabolic process
H4N61_RS03520	COG4172	Belongs to the ABC transporter superfamily
H4N61_RS03525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4N61_RS03530	COG0601	transmembrane transport
H4N61_RS03535	COG0747	negative chemotaxis
H4N61_RS03545	COG1609	Transcriptional regulator
H4N61_RS03550	COG1129	ABC transporter
H4N61_RS03555	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4N61_RS03560	COG1879	ABC-type sugar transport system periplasmic component
H4N61_RS03570	COG0789	Transcriptional regulator
H4N61_RS03585	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H4N61_RS03590	COG4988	ABC transporter
H4N61_RS03600	COG1294	oxidase, subunit
H4N61_RS03635	COG4952	isomerase
H4N61_RS03640	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS03640	COG3347	Dehydrogenase
H4N61_RS03655	COG1129	ABC transporter
H4N61_RS03665	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4N61_RS03670	COG3254	rhamnose metabolic process
H4N61_RS03695	COG0433	COG0433 Predicted ATPase
H4N61_RS03715	COG2198	Histidine kinase
H4N61_RS03715	COG0784	Response regulator, receiver
H4N61_RS03715	COG0643	Histidine kinase
H4N61_RS03720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4N61_RS03740	COG1006	Multisubunit Na H antiporter MnhC subunit
H4N61_RS03755	COG2212	antiporter activity
H4N61_RS03760	COG1320	monovalent cation:proton antiporter activity
H4N61_RS03765	COG4957	zinc ion binding
H4N61_RS03780	COG2166	iron-sulfur cluster assembly
H4N61_RS03790	COG2205	protein histidine kinase activity
H4N61_RS03860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4N61_RS03865	COG2983	Belongs to the UPF0260 family
H4N61_RS03875	COG0443	Heat shock 70 kDa protein
H4N61_RS03910	COG0745	RESPONSE REGULATOR receiver
H4N61_RS03915	COG2205	protein histidine kinase activity
H4N61_RS03930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H4N61_RS03930	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4N61_RS03945	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H4N61_RS03950	COG1138	Cytochrome C-type biogenesis protein
H4N61_RS03955	COG3088	subunit of a heme lyase
H4N61_RS03960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4N61_RS03965	COG0745	RESPONSE REGULATOR receiver
H4N61_RS03980	COG2205	protein histidine kinase activity
H4N61_RS03980	COG2202	Pas domain
H4N61_RS03985	COG0308	aminopeptidase N
H4N61_RS03990	COG1132	(ABC) transporter
H4N61_RS03995	COG3077	Addiction module antitoxin, RelB DinJ family
H4N61_RS04000	COG3250	beta-galactosidase activity
H4N61_RS04010	COG1252	NADH dehydrogenase
H4N61_RS04040	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H4N61_RS04045	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H4N61_RS04055	COG2205	protein histidine kinase activity
H4N61_RS04055	COG2202	Pas domain
H4N61_RS04060	COG1522	sequence-specific DNA binding
H4N61_RS04065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H4N61_RS04070	COG1376	ErfK ybiS ycfS ynhG family protein
H4N61_RS04075	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H4N61_RS04090	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H4N61_RS04100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4N61_RS04115	COG0215	cysteine-tRNA ligase activity
H4N61_RS04130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4N61_RS04135	COG1652	LysM domain
H4N61_RS04145	COG5265	(ABC) transporter
H4N61_RS04150	COG1218	3'(2'),5'-bisphosphate nucleotidase
H4N61_RS04155	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS04165	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H4N61_RS04170	COG2902	Dehydrogenase
H4N61_RS04180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4N61_RS04195	COG0604	alcohol dehydrogenase
H4N61_RS04220	COG0642	Histidine kinase
H4N61_RS04230	COG2199	diguanylate cyclase activity
H4N61_RS04230	COG2200	EAL domain
H4N61_RS04235	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H4N61_RS04240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4N61_RS04240	COG3453	Protein conserved in bacteria
H4N61_RS04265	COG3706	GGDEF domain
H4N61_RS04275	COG1473	amidohydrolase
H4N61_RS04285	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H4N61_RS04300	COG3842	ATPase activity
H4N61_RS04305	COG1177	transmembrane transport
H4N61_RS04310	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4N61_RS04320	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H4N61_RS04325	COG0778	Nitroreductase
H4N61_RS04365	COG1131	(ABC) transporter
H4N61_RS04375	COG0583	DNA-binding transcription factor activity
H4N61_RS04380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4N61_RS04405	COG1082	Xylose isomerase domain protein TIM barrel
H4N61_RS04410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H4N61_RS04415	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4N61_RS04425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4N61_RS04435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4N61_RS04440	COG1309	transcriptional regulator
H4N61_RS04450	COG2186	Transcriptional regulator
H4N61_RS04455	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4N61_RS04460	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4N61_RS04465	COG1129	ABC transporter
H4N61_RS04470	COG1879	ABC-type sugar transport system periplasmic component
H4N61_RS04490	COG1053	succinate dehydrogenase
H4N61_RS04520	COG0584	glycerophosphoryl diester phosphodiesterase
H4N61_RS04525	COG3842	ATPase activity
H4N61_RS04530	COG0395	ABC-type sugar transport system, permease component
H4N61_RS04540	COG1653	transport
H4N61_RS04560	COG5001	Diguanylate cyclase
H4N61_RS04565	COG5002	protein histidine kinase activity
H4N61_RS04565	COG5001	Diguanylate cyclase
H4N61_RS04565	COG3447	MASE1 domain protein
H4N61_RS04585	COG0589	response to stress
H4N61_RS04595	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H4N61_RS04605	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H4N61_RS04615	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H4N61_RS04620	COG2871	sodium ion transport
H4N61_RS04650	COG3842	ATPase activity
H4N61_RS04665	COG1349	DNA-binding transcription factor activity
H4N61_RS04675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H4N61_RS04680	COG0477	Major facilitator Superfamily
H4N61_RS04705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H4N61_RS04705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4N61_RS04715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4N61_RS04715	COG0519	Catalyzes the synthesis of GMP from XMP
H4N61_RS04720	COG3447	MASE1 domain protein
H4N61_RS04720	COG5002	protein histidine kinase activity
H4N61_RS04720	COG5001	Diguanylate cyclase
H4N61_RS04730	COG1160	GTP binding
H4N61_RS04735	COG1253	flavin adenine dinucleotide binding
H4N61_RS04740	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS04745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H4N61_RS04760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H4N61_RS04775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H4N61_RS04780	COG0360	Binds together with S18 to 16S ribosomal RNA
H4N61_RS04785	COG3706	GGDEF domain
H4N61_RS04790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H4N61_RS04800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4N61_RS04805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4N61_RS04810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4N61_RS04820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H4N61_RS04870	COG0488	(ABC) transporter
H4N61_RS04880	COG0105	UTP biosynthetic process
H4N61_RS04895	COG2814	Major facilitator Superfamily
H4N61_RS04905	COG0243	molybdopterin cofactor binding
H4N61_RS04935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H4N61_RS04975	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H4N61_RS04990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H4N61_RS04995	COG0583	DNA-binding transcription factor activity
H4N61_RS05000	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H4N61_RS05015	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4N61_RS05020	COG1177	transmembrane transport
H4N61_RS05025	COG3842	ATPase activity
H4N61_RS05030	COG1012	belongs to the aldehyde dehydrogenase family
H4N61_RS05035	COG0583	DNA-binding transcription factor activity
H4N61_RS05045	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H4N61_RS05050	COG2113	Glycine betaine
H4N61_RS05055	COG4176	ABC-type proline glycine betaine transport system permease component
H4N61_RS05060	COG3448	diguanylate cyclase activity
H4N61_RS05060	COG4175	Glycine betaine
H4N61_RS05070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4N61_RS05080	COG0798	PFAM Bile acid sodium symporter
H4N61_RS05090	COG0431	NADPH-dependent FMN reductase
H4N61_RS05135	COG1012	belongs to the aldehyde dehydrogenase family
H4N61_RS05140	COG1454	alcohol dehydrogenase
H4N61_RS05160	COG2207	Transcriptional regulator
H4N61_RS05160	COG1609	Transcriptional regulator
H4N61_RS05185	COG4177	L-phenylalanine transmembrane transporter activity
H4N61_RS05195	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS05210	COG1959	2 iron, 2 sulfur cluster binding
H4N61_RS05225	COG0848	biopolymer transport protein
H4N61_RS05235	COG4206	TonB-dependent receptor
H4N61_RS05260	COG1120	ATPase activity
H4N61_RS05265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4N61_RS05360	COG2204	response regulator
H4N61_RS05365	COG4191	Histidine kinase
H4N61_RS05370	COG1301	dicarboxylic acid transport
H4N61_RS05385	COG0730	response to heat
H4N61_RS05390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4N61_RS05395	COG3119	arylsulfatase activity
H4N61_RS05430	COG1120	ATPase activity
H4N61_RS05450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4N61_RS05470	COG1309	transcriptional regulator
H4N61_RS05475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4N61_RS05510	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4N61_RS05515	COG3971	2-oxopent-4-enoate hydratase activity
H4N61_RS05530	COG1802	Transcriptional regulator
H4N61_RS05585	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS05595	COG0673	inositol 2-dehydrogenase activity
H4N61_RS05635	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H4N61_RS05665	COG0714	Associated with various cellular activities
H4N61_RS05695	COG3258	Cytochrome c
H4N61_RS05705	COG4206	TonB-dependent receptor
H4N61_RS05710	COG1278	Cold shock
H4N61_RS05720	COG0251	oxidation-reduction process
H4N61_RS05730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4N61_RS05750	COG1744	ABC transporter substrate-binding protein PnrA-like
H4N61_RS05755	COG2188	Transcriptional regulator
H4N61_RS05765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4N61_RS05770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4N61_RS05775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4N61_RS05785	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H4N61_RS05790	COG2188	Transcriptional regulator
H4N61_RS05795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H4N61_RS05820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4N61_RS05825	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H4N61_RS05835	COG1758	RNA polymerase activity
H4N61_RS05845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H4N61_RS05850	COG0736	holo-[acyl-carrier-protein] synthase activity
H4N61_RS05855	COG0681	Belongs to the peptidase S26 family
H4N61_RS05860	COG0571	ribonuclease III activity
H4N61_RS05865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H4N61_RS05870	COG1381	Involved in DNA repair and RecF pathway recombination
H4N61_RS05880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H4N61_RS05885	COG0840	transmembrane signaling receptor activity
H4N61_RS05895	COG0463	Glycosyl transferase, family 2
H4N61_RS05900	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H4N61_RS05920	COG0113	porphobilinogen synthase activity
H4N61_RS05950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H4N61_RS05955	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H4N61_RS05985	COG0416	fatty acid biosynthetic process
H4N61_RS05990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4N61_RS05995	COG0776	regulation of translation
H4N61_RS06010	COG0697	spore germination
H4N61_RS06035	COG1596	polysaccharide export
H4N61_RS06055	COG1612	heme a metabolic process
H4N61_RS06060	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H4N61_RS06075	COG1301	dicarboxylic acid transport
H4N61_RS06080	COG2124	cytochrome p450
H4N61_RS06090	COG0740	serine-type endopeptidase activity
H4N61_RS06095	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H4N61_RS06100	COG0010	Belongs to the arginase family
H4N61_RS06105	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H4N61_RS06110	COG1819	glycosyl
H4N61_RS06115	COG0436	Aminotransferase
H4N61_RS06140	COG1494	fructose-1,6-bisphosphatase
H4N61_RS06150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4N61_RS06175	COG0346	lactoylglutathione lyase activity
H4N61_RS06180	COG1278	Cold shock
H4N61_RS06190	COG1272	protein, Hemolysin III
H4N61_RS06195	COG0640	Transcriptional regulator
H4N61_RS06205	COG0489	protein tyrosine kinase activity
H4N61_RS06210	COG1346	cytolysis
H4N61_RS06235	COG4172	Belongs to the ABC transporter superfamily
H4N61_RS06240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4N61_RS06250	COG0747	negative chemotaxis
H4N61_RS06270	COG2814	Major facilitator Superfamily
H4N61_RS06380	COG3750	Belongs to the UPF0335 family
H4N61_RS06405	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H4N61_RS06445	COG0776	regulation of translation
H4N61_RS06480	COG5518	Phage portal protein
H4N61_RS06485	COG0740	serine-type endopeptidase activity
H4N61_RS06570	COG2755	lipolytic protein G-D-S-L family
H4N61_RS06570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H4N61_RS06575	COG3108	Peptidase M15
H4N61_RS06605	COG1609	Transcriptional regulator
H4N61_RS06610	COG1653	transport
H4N61_RS06615	COG1175	transmembrane transport
H4N61_RS06620	COG0395	ABC-type sugar transport system, permease component
H4N61_RS06625	COG3842	ATPase activity
H4N61_RS06645	COG0673	inositol 2-dehydrogenase activity
H4N61_RS06680	COG0626	cystathionine gamma-synthase activity
H4N61_RS06685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4N61_RS06690	COG4597	amino acid ABC transporter
H4N61_RS06695	COG0765	amino acid transport
H4N61_RS06700	COG1126	abc transporter atp-binding protein
H4N61_RS06705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4N61_RS06710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4N61_RS06715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4N61_RS06725	COG0415	Belongs to the DNA photolyase family
H4N61_RS06735	COG2223	nitrite transmembrane transporter activity
H4N61_RS06755	COG3135	benzoate transporter
H4N61_RS06775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4N61_RS06790	COG0525	valine-tRNA ligase activity
H4N61_RS06810	COG0316	Belongs to the HesB IscA family
H4N61_RS06815	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H4N61_RS06820	COG0018	arginyl-trna synthetase
H4N61_RS06830	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H4N61_RS06835	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H4N61_RS06840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4N61_RS06845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4N61_RS06850	COG0805	protein transport
H4N61_RS06860	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H4N61_RS06875	COG1862	Preprotein translocase
H4N61_RS06900	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H4N61_RS06910	COG1192	Involved in chromosome partitioning
H4N61_RS06915	COG1733	regulation of RNA biosynthetic process
H4N61_RS06920	COG1686	Belongs to the peptidase S11 family
H4N61_RS06925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4N61_RS06925	COG0425	Belongs to the sulfur carrier protein TusA family
H4N61_RS06940	COG1132	(ABC) transporter
H4N61_RS06945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4N61_RS06950	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4N61_RS06955	COG1120	ATPase activity
H4N61_RS06995	COG0840	transmembrane signaling receptor activity
H4N61_RS07010	COG0242	peptide deformylase activity
H4N61_RS07020	COG0739	heme binding
H4N61_RS07025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H4N61_RS07035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H4N61_RS07040	COG2945	thiolester hydrolase activity
H4N61_RS07050	COG0719	Fe-S assembly protein
H4N61_RS07055	COG0396	ATPase activity
H4N61_RS07060	COG0719	Fe-S assembly protein
H4N61_RS07065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4N61_RS07070	COG2151	metal-sulfur cluster biosynthetic enzyme
H4N61_RS07075	COG0316	Belongs to the HesB IscA family
H4N61_RS07080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H4N61_RS07085	COG3706	GGDEF domain
H4N61_RS07090	COG0513	Belongs to the DEAD box helicase family
H4N61_RS07095	COG0187	DNA topoisomerase II activity
H4N61_RS07100	COG3328	transposase activity
H4N61_RS07120	COG0544	peptidyl-prolyl cis-trans isomerase activity
H4N61_RS07130	COG0347	Belongs to the P(II) protein family
H4N61_RS07135	COG0174	glutamine synthetase
H4N61_RS07150	COG0601	transmembrane transport
H4N61_RS07170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4N61_RS07190	COG1253	flavin adenine dinucleotide binding
H4N61_RS07205	COG0670	Belongs to the BI1 family
H4N61_RS07225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4N61_RS07230	COG0747	negative chemotaxis
H4N61_RS07245	COG0444	Belongs to the ABC transporter superfamily
H4N61_RS07250	COG4608	Belongs to the ABC transporter superfamily
H4N61_RS07295	COG2198	Histidine kinase
H4N61_RS07295	COG0784	Response regulator, receiver
H4N61_RS07295	COG5002	protein histidine kinase activity
H4N61_RS07300	COG0745	RESPONSE REGULATOR receiver
H4N61_RS07310	COG3842	ATPase activity
H4N61_RS07315	COG0395	ABC-type sugar transport system, permease component
H4N61_RS07320	COG1175	transmembrane transport
H4N61_RS07340	COG2197	response regulator
H4N61_RS07360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4N61_RS07365	COG0183	Belongs to the thiolase family
H4N61_RS07370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4N61_RS07380	COG1414	Transcriptional regulator
H4N61_RS07400	COG3320	Male sterility
H4N61_RS07400	COG1022	Amp-dependent synthetase and ligase
H4N61_RS07405	COG0183	Belongs to the thiolase family
H4N61_RS07420	COG1024	Enoyl-CoA hydratase
H4N61_RS07440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4N61_RS07455	COG0583	DNA-binding transcription factor activity
H4N61_RS07465	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4N61_RS07470	COG3485	protocatechuate 3,4-dioxygenase
H4N61_RS07475	COG3485	protocatechuate 3,4-dioxygenase
H4N61_RS07500	COG1940	carbohydrate kinase activity
H4N61_RS07505	COG2182	Extracellular solute-binding protein
H4N61_RS07510	COG1175	transmembrane transport
H4N61_RS07515	COG0395	ABC-type sugar transport system, permease component
H4N61_RS07520	COG0165	Argininosuccinate lyase
H4N61_RS07525	COG3842	ATPase activity
H4N61_RS07530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4N61_RS07535	COG2188	Transcriptional regulator
H4N61_RS07540	COG0747	negative chemotaxis
H4N61_RS07545	COG0601	transmembrane transport
H4N61_RS07550	COG0444	Belongs to the ABC transporter superfamily
H4N61_RS07555	COG4608	Belongs to the ABC transporter superfamily
H4N61_RS07560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4N61_RS07565	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H4N61_RS07595	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4N61_RS07600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4N61_RS07605	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4N61_RS07610	COG0649	NAD binding
H4N61_RS07615	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H4N61_RS07625	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H4N61_RS07635	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H4N61_RS07640	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4N61_RS07650	COG0713	ATP synthesis coupled electron transport
H4N61_RS07665	COG1007	ATP synthesis coupled electron transport
H4N61_RS07670	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H4N61_RS07670	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H4N61_RS07685	COG0442	prolyl-tRNA aminoacylation
H4N61_RS07695	COG1136	(ABC) transporter
H4N61_RS07705	COG0052	Belongs to the universal ribosomal protein uS2 family
H4N61_RS07710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H4N61_RS07720	COG0233	cytoplasmic translational termination
H4N61_RS07725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H4N61_RS07740	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4N61_RS07745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4N61_RS07750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H4N61_RS07755	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4N61_RS07760	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4N61_RS07765	COG0372	Belongs to the citrate synthase family
H4N61_RS07785	COG3386	PFAM SMP-30 Gluconolaconase
H4N61_RS07790	COG0800	Aldolase
H4N61_RS07795	COG3734	2-keto-3-deoxy-galactonokinase
H4N61_RS07800	COG0129	dihydroxy-acid dehydratase activity
H4N61_RS07805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H4N61_RS07830	COG0402	S-adenosylhomocysteine deaminase activity
H4N61_RS07835	COG0395	ABC-type sugar transport system, permease component
H4N61_RS07850	COG3842	ATPase activity
H4N61_RS07855	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS07865	COG3806	Anti-sigma factor
H4N61_RS07870	COG1595	DNA-templated transcription, initiation
H4N61_RS07885	COG0303	'Molybdopterin
H4N61_RS07890	COG0315	cyclic pyranopterin monophosphate synthase activity
H4N61_RS07895	COG0134	indole-3-glycerol-phosphate synthase activity
H4N61_RS07900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4N61_RS07910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H4N61_RS07920	COG0149	triose-phosphate isomerase activity
H4N61_RS07930	COG0504	CTP synthase activity
H4N61_RS07945	COG0477	Major facilitator Superfamily
H4N61_RS07960	COG0148	phosphopyruvate hydratase activity
H4N61_RS07980	COG1410	methionine synthase
H4N61_RS07980	COG0646	methionine synthase
H4N61_RS07990	COG1686	Belongs to the peptidase S11 family
H4N61_RS07995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H4N61_RS08010	COG0084	hydrolase, TatD family'
H4N61_RS08020	COG1464	Belongs to the NlpA lipoprotein family
H4N61_RS08025	COG2011	ABC-type metal ion transport system permease component
H4N61_RS08030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4N61_RS08035	COG3842	ATPase activity
H4N61_RS08040	COG0395	ABC-type sugar transport system, permease component
H4N61_RS08045	COG1175	transmembrane transport
H4N61_RS08065	COG1609	Transcriptional regulator
H4N61_RS08070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H4N61_RS08085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H4N61_RS08090	COG1061	Type III restriction enzyme res subunit
H4N61_RS08095	COG1002	Type II restriction enzyme, methylase subunits
H4N61_RS08105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4N61_RS08115	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H4N61_RS08150	COG1305	Transglutaminase-like
H4N61_RS08165	COG3956	TIGRFAM MazG family protein
H4N61_RS08175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4N61_RS08180	COG1923	regulation of RNA biosynthetic process
H4N61_RS08185	COG2204	response regulator
H4N61_RS08190	COG5000	phosphorelay sensor kinase activity
H4N61_RS08195	COG2204	response regulator
H4N61_RS08200	COG3852	Histidine kinase
H4N61_RS08205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4N61_RS08210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H4N61_RS08210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H4N61_RS08215	COG1058	Belongs to the CinA family
H4N61_RS08215	COG1546	Belongs to the CinA family
H4N61_RS08225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H4N61_RS08235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4N61_RS08255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H4N61_RS08260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4N61_RS08270	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4N61_RS08275	COG0022	dehydrogenase e1 component
H4N61_RS08275	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4N61_RS08280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H4N61_RS08295	COG0281	malic enzyme
H4N61_RS08295	COG0280	phosphate acetyltransferase
H4N61_RS08300	COG2200	EAL domain
H4N61_RS08305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H4N61_RS08310	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H4N61_RS08320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H4N61_RS08330	COG0628	permease
H4N61_RS08335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H4N61_RS08340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H4N61_RS08345	COG0697	spore germination
H4N61_RS08350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H4N61_RS08370	COG0154	amidase activity
H4N61_RS08380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H4N61_RS08390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H4N61_RS08395	COG0540	Belongs to the ATCase OTCase family
H4N61_RS08410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4N61_RS08410	COG1754	DNA topoisomerase type I activity
H4N61_RS08420	COG0758	DNA mediated transformation
H4N61_RS08425	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H4N61_RS08430	COG0557	exoribonuclease II activity
H4N61_RS08440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H4N61_RS08450	COG0784	Response regulator, receiver
H4N61_RS08460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4N61_RS08475	COG0537	adenosine 5'-monophosphoramidase activity
H4N61_RS08485	COG0659	secondary active sulfate transmembrane transporter activity
H4N61_RS08495	COG0601	transmembrane transport
H4N61_RS08500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4N61_RS08505	COG0444	Belongs to the ABC transporter superfamily
H4N61_RS08515	COG4166	transmembrane transport
H4N61_RS08530	COG0405	Gamma-glutamyltransferase
H4N61_RS08535	COG1522	sequence-specific DNA binding
H4N61_RS08545	COG3842	ATPase activity
H4N61_RS08550	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4N61_RS08555	COG1177	transmembrane transport
H4N61_RS08575	COG0730	response to heat
H4N61_RS08580	COG3842	ATPase activity
H4N61_RS08590	COG0395	ABC-type sugar transport system, permease component
H4N61_RS08595	COG2186	Transcriptional regulator
H4N61_RS08600	COG4948	Mandelate Racemase Muconate Lactonizing
H4N61_RS08615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H4N61_RS08615	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4N61_RS08625	COG1175	transmembrane transport
H4N61_RS08630	COG0395	ABC-type sugar transport system, permease component
H4N61_RS08635	COG3842	ATPase activity
H4N61_RS08670	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4N61_RS08675	COG1129	ABC transporter
H4N61_RS08740	COG4691	Plasmid stability protein
H4N61_RS08760	COG1686	Belongs to the peptidase S11 family
H4N61_RS08770	COG0534	Mate efflux family protein
H4N61_RS08800	COG1530	ribonuclease E activity
H4N61_RS08815	COG0436	Aminotransferase
H4N61_RS08830	COG0511	ligase activity, forming carbon-carbon bonds
H4N61_RS08840	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H4N61_RS08865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4N61_RS08940	COG0395	ABC-type sugar transport system, permease component
H4N61_RS08960	COG0784	Response regulator, receiver
H4N61_RS08960	COG4191	Histidine kinase
H4N61_RS08980	COG2113	Glycine betaine
H4N61_RS08985	COG4176	ABC-type proline glycine betaine transport system permease component
H4N61_RS08990	COG4175	Glycine betaine
H4N61_RS08990	COG3448	diguanylate cyclase activity
H4N61_RS08995	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS09015	COG2963	transposase activity
H4N61_RS09020	COG3436	PFAM IS66 Orf2 family protein
H4N61_RS09025	COG2433	Pfam Transposase IS66
H4N61_RS09085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H4N61_RS09085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H4N61_RS09095	COG1609	Transcriptional regulator
H4N61_RS09110	COG0395	ABC-type sugar transport system, permease component
H4N61_RS09115	COG3842	ATPase activity
H4N61_RS09125	COG1082	Xylose isomerase domain protein TIM barrel
H4N61_RS09130	COG1609	Transcriptional regulator
H4N61_RS09140	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4N61_RS09150	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H4N61_RS09160	COG0483	inositol monophosphate 1-phosphatase activity
H4N61_RS09170	COG3842	ATPase activity
H4N61_RS09180	COG3833	ABC-type maltose transport systems, permease component
H4N61_RS09185	COG1175	transmembrane transport
H4N61_RS09195	COG1609	Transcriptional regulator
H4N61_RS09210	COG1131	(ABC) transporter
H4N61_RS09235	COG2084	Dehydrogenase
H4N61_RS09240	COG3622	Belongs to the hyi family
H4N61_RS09250	COG0673	inositol 2-dehydrogenase activity
H4N61_RS09260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4N61_RS09275	COG0747	negative chemotaxis
H4N61_RS09285	COG1069	ribulokinase activity
H4N61_RS09300	COG0745	RESPONSE REGULATOR receiver
H4N61_RS09305	COG2205	protein histidine kinase activity
H4N61_RS09315	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H4N61_RS09320	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H4N61_RS09335	COG4948	Mandelate Racemase Muconate Lactonizing
H4N61_RS09345	COG0395	ABC-type sugar transport system, permease component
H4N61_RS09350	COG1175	transmembrane transport
H4N61_RS09370	COG3386	PFAM SMP-30 Gluconolaconase
H4N61_RS09410	COG1073	alpha beta
H4N61_RS09415	COG1174	glycine betaine transport
H4N61_RS09420	COG1125	glycine betaine transport
H4N61_RS09425	COG1174	glycine betaine transport
H4N61_RS09430	COG1732	Glycine betaine
H4N61_RS09440	COG1609	Transcriptional regulator
H4N61_RS09450	COG0673	inositol 2-dehydrogenase activity
H4N61_RS09455	COG1879	ABC-type sugar transport system periplasmic component
H4N61_RS09460	COG4211	Belongs to the binding-protein-dependent transport system permease family
H4N61_RS09475	COG0673	inositol 2-dehydrogenase activity
H4N61_RS09480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4N61_RS09485	COG3962	Belongs to the TPP enzyme family
H4N61_RS09495	COG3718	enzyme involved in inositol metabolism
H4N61_RS09515	COG0667	Aldo Keto reductase
H4N61_RS09520	COG4948	Mandelate Racemase Muconate Lactonizing
H4N61_RS09525	COG1802	Transcriptional regulator
H4N61_RS09545	COG3842	ATPase activity
H4N61_RS09550	COG4948	Mandelate Racemase Muconate Lactonizing
H4N61_RS09585	COG0747	negative chemotaxis
H4N61_RS09590	COG3386	PFAM SMP-30 Gluconolaconase
H4N61_RS09600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4N61_RS09615	COG1780	Probably involved in ribonucleotide reductase function
H4N61_RS09620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H4N61_RS09630	COG1187	pseudouridine synthase activity
H4N61_RS09635	COG2223	nitrite transmembrane transporter activity
H4N61_RS09665	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4N61_RS09675	COG1215	transferase activity, transferring glycosyl groups
H4N61_RS09680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4N61_RS09685	COG5002	protein histidine kinase activity
H4N61_RS09700	COG3800	Transcriptional regulator
H4N61_RS09700	COG1396	sequence-specific DNA binding
H4N61_RS09715	COG4214	carbohydrate transport
H4N61_RS09730	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H4N61_RS09735	COG1984	allophanate hydrolase subunit 2
H4N61_RS09755	COG1760	l-serine dehydratase
H4N61_RS09765	COG3534	alpha-L-arabinofuranosidase
H4N61_RS09770	COG1609	Transcriptional regulator
H4N61_RS09775	COG1609	Transcriptional regulator
H4N61_RS09780	COG3250	beta-galactosidase activity
H4N61_RS09785	COG3842	ATPase activity
H4N61_RS09795	COG1175	transmembrane transport
H4N61_RS09800	COG0395	ABC-type sugar transport system, permease component
H4N61_RS09865	COG1253	flavin adenine dinucleotide binding
H4N61_RS09870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4N61_RS09880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H4N61_RS09885	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H4N61_RS09890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4N61_RS09895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4N61_RS09900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H4N61_RS09925	COG0024	Methionine aminopeptidase
H4N61_RS09935	COG0343	queuine tRNA-ribosyltransferase activity
H4N61_RS09950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H4N61_RS09970	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H4N61_RS09990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H4N61_RS10005	COG5001	Diguanylate cyclase
H4N61_RS10005	COG3300	MHYT domain
H4N61_RS10015	COG0629	single-stranded DNA binding
H4N61_RS10020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4N61_RS10030	COG0625	glutathione transferase activity
H4N61_RS10035	COG2239	Acts as a magnesium transporter
H4N61_RS10075	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4N61_RS10080	COG0321	lipoyl(octanoyl) transferase activity
H4N61_RS10095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4N61_RS10110	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H4N61_RS10115	COG4208	sulfate ABC transporter
H4N61_RS10120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H4N61_RS10125	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H4N61_RS10130	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H4N61_RS10140	COG0546	phosphoglycolate phosphatase activity
H4N61_RS10150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H4N61_RS10155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H4N61_RS10160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4N61_RS10175	COG0203	ribosomal protein L17
H4N61_RS10180	COG0202	RNA polymerase activity
H4N61_RS10185	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H4N61_RS10190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H4N61_RS10195	COG0563	adenylate kinase activity
H4N61_RS10200	COG0201	protein transport
H4N61_RS10205	COG0200	Binds to the 23S rRNA
H4N61_RS10210	COG1841	ribosomal large subunit assembly
H4N61_RS10215	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H4N61_RS10220	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H4N61_RS10225	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H4N61_RS10235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H4N61_RS10240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H4N61_RS10245	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H4N61_RS10250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H4N61_RS10255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H4N61_RS10260	COG0255	Belongs to the universal ribosomal protein uL29 family
H4N61_RS10265	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H4N61_RS10270	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H4N61_RS10275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H4N61_RS10280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H4N61_RS10285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H4N61_RS10290	COG0089	rRNA binding
H4N61_RS10295	COG0088	Forms part of the polypeptide exit tunnel
H4N61_RS10300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H4N61_RS10305	COG0051	transcription antitermination factor activity, RNA binding
H4N61_RS10310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H4N61_RS10315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H4N61_RS10320	COG0049	tRNA binding
H4N61_RS10325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H4N61_RS10330	COG0492	ferredoxin-NADP+ reductase activity
H4N61_RS10335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H4N61_RS10340	COG0085	RNA polymerase activity
H4N61_RS10345	COG0222	ribosome binding
H4N61_RS10350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H4N61_RS10355	COG0081	regulation of translation
H4N61_RS10360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H4N61_RS10370	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4N61_RS10395	COG3706	GGDEF domain
H4N61_RS10415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4N61_RS10435	COG1671	Belongs to the UPF0178 family
H4N61_RS10440	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H4N61_RS10450	COG1129	ABC transporter
H4N61_RS10455	COG4214	carbohydrate transport
H4N61_RS10460	COG4213	ABC transporter substrate-binding protein
H4N61_RS10470	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H4N61_RS10470	COG0662	Cupin 2, conserved barrel domain protein
H4N61_RS10480	COG0175	sulfate reduction
H4N61_RS10520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H4N61_RS10590	COG1401	restriction endodeoxyribonuclease activity
H4N61_RS10655	COG4584	PFAM Integrase catalytic
H4N61_RS10670	COG3920	Histidine kinase
H4N61_RS10675	COG0784	Response regulator, receiver
H4N61_RS10675	COG4191	Histidine kinase
H4N61_RS10680	COG0438	transferase activity, transferring glycosyl groups
H4N61_RS10705	COG3546	catalase activity
H4N61_RS10710	COG0596	Alpha beta hydrolase
H4N61_RS10745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H4N61_RS10780	COG5001	Diguanylate cyclase
H4N61_RS10790	COG0489	protein tyrosine kinase activity
H4N61_RS10790	COG3206	protein involved in exopolysaccharide biosynthesis
H4N61_RS10795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H4N61_RS10825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4N61_RS10830	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H4N61_RS10845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H4N61_RS10850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H4N61_RS10860	COG0302	gtp cyclohydrolase
H4N61_RS10865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H4N61_RS10910	COG2267	carboxylic ester hydrolase activity
H4N61_RS10935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H4N61_RS10940	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS10950	COG2954	triphosphatase activity
H4N61_RS10970	COG0346	lactoylglutathione lyase activity
H4N61_RS10975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H4N61_RS11010	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H4N61_RS11015	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4N61_RS11020	COG0840	transmembrane signaling receptor activity
H4N61_RS11030	COG0785	Cytochrome C biogenesis protein
H4N61_RS11035	COG2003	Belongs to the UPF0758 family
H4N61_RS11040	COG0024	Methionine aminopeptidase
H4N61_RS11045	COG1546	Belongs to the CinA family
H4N61_RS11045	COG1058	Belongs to the CinA family
H4N61_RS11050	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H4N61_RS11070	COG0251	oxidation-reduction process
H4N61_RS11085	COG0047	phosphoribosylformylglycinamidine synthase activity
H4N61_RS11090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4N61_RS11110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H4N61_RS11125	COG2271	Major facilitator Superfamily
H4N61_RS11130	COG0483	inositol monophosphate 1-phosphatase activity
H4N61_RS11135	COG0037	tRNA processing
H4N61_RS11140	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H4N61_RS11165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4N61_RS11180	COG0538	isocitrate dehydrogenase activity
H4N61_RS11190	COG0697	spore germination
H4N61_RS11195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4N61_RS11200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H4N61_RS11215	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4N61_RS11220	COG1684	flagellar biosynthetic protein fliR
H4N61_RS11225	COG1987	bacterial-type flagellum assembly
H4N61_RS11230	COG1677	Flagellar hook-basal body complex protein FliE
H4N61_RS11235	COG1558	bacterial-type flagellum-dependent cell motility
H4N61_RS11240	COG1815	bacterial-type flagellum-dependent cell motility
H4N61_RS11250	COG1338	Plays a role in the flagellum-specific transport system
H4N61_RS11275	COG1580	Controls the rotational direction of flagella during chemotaxis
H4N61_RS11280	COG4786	Flagellar basal body rod
H4N61_RS11285	COG4786	Flagellar basal body rod
H4N61_RS11300	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H4N61_RS11330	COG1706	bacterial-type flagellum-dependent cell motility
H4N61_RS11345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4N61_RS11360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4N61_RS11365	COG5443	negative regulation of bacterial-type flagellum assembly
H4N61_RS11395	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H4N61_RS11400	COG3106	COG3106 Predicted ATPase
H4N61_RS11410	COG2200	EAL domain
H4N61_RS11420	COG0492	ferredoxin-NADP+ reductase activity
H4N61_RS11425	COG0175	sulfate reduction
H4N61_RS11430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4N61_RS11440	COG1648	precorrin-2 dehydrogenase activity
H4N61_RS11440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H4N61_RS11445	COG0633	Ferredoxin
H4N61_RS11475	COG2814	Major facilitator Superfamily
H4N61_RS11485	COG1472	Belongs to the glycosyl hydrolase 3 family
H4N61_RS11490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4N61_RS11510	COG0861	Integral membrane protein TerC family
H4N61_RS11540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4N61_RS11550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4N61_RS11565	COG0384	phenazine biosynthesis protein PhzF
H4N61_RS11570	COG4702	Belongs to the UPF0303 family
H4N61_RS11585	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H4N61_RS11590	COG1309	transcriptional regulator
H4N61_RS11600	COG0642	Histidine kinase
H4N61_RS11605	COG0745	RESPONSE REGULATOR receiver
H4N61_RS11620	COG1840	ABC-type Fe3 transport system, periplasmic component
H4N61_RS11635	COG2391	methyltransferase activity
H4N61_RS11645	COG1902	pentaerythritol trinitrate reductase activity
H4N61_RS11665	COG0440	acetolactate synthase activity
H4N61_RS11670	COG0028	Belongs to the TPP enzyme family
H4N61_RS11675	COG0306	phosphate transporter
H4N61_RS11685	COG1278	Cold shock
H4N61_RS11705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H4N61_RS11710	COG3830	Belongs to the UPF0237 family
H4N61_RS11710	COG0560	Phosphoserine phosphatase
H4N61_RS11715	COG0330	HflC and HflK could
H4N61_RS11720	COG0330	HflC and HflK could
H4N61_RS11745	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H4N61_RS11795	COG2264	protein methyltransferase activity
H4N61_RS11800	COG0006	proline dipeptidase activity
H4N61_RS11805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H4N61_RS11815	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4N61_RS11820	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H4N61_RS11825	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H4N61_RS11830	COG0849	cell division
H4N61_RS11835	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H4N61_RS11840	COG1181	Belongs to the D-alanine--D-alanine ligase family
H4N61_RS11845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4N61_RS11850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H4N61_RS11860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4N61_RS11865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H4N61_RS11870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4N61_RS11885	COG0275	rRNA processing
H4N61_RS11895	COG0784	Response regulator, receiver
H4N61_RS11900	COG3920	Histidine kinase
H4N61_RS11910	COG0019	diaminopimelate decarboxylase activity
H4N61_RS11920	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H4N61_RS11930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H4N61_RS11935	COG0640	Transcriptional regulator
H4N61_RS11940	COG0668	transmembrane transport
H4N61_RS11955	COG0745	RESPONSE REGULATOR receiver
H4N61_RS11965	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H4N61_RS11990	COG2267	carboxylic ester hydrolase activity
H4N61_RS12010	COG0488	(ABC) transporter
H4N61_RS12015	COG0612	Peptidase, M16
H4N61_RS12020	COG0612	Peptidase, M16
H4N61_RS12030	COG3706	GGDEF domain
H4N61_RS12050	COG0829	nickel cation binding
H4N61_RS12055	COG0831	urea catabolic process
H4N61_RS12065	COG0832	Belongs to the urease beta subunit family
H4N61_RS12075	COG0804	urea catabolic process
H4N61_RS12085	COG3895	Periplasmic Protein
H4N61_RS12100	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H4N61_RS12105	COG0830	nickel cation binding
H4N61_RS12115	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H4N61_RS12130	COG0033	Phosphoglucomutase
H4N61_RS12135	COG0297	glycogen (starch) synthase activity
H4N61_RS12140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H4N61_RS12145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H4N61_RS12150	COG0058	SHG alpha-glucan phosphorylase activity
H4N61_RS12155	COG0475	glutathione-regulated potassium exporter activity
H4N61_RS12155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4N61_RS12160	COG1957	nucleoside hydrolase
H4N61_RS12170	COG1280	lysine exporter protein (LysE YggA)
H4N61_RS12195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4N61_RS12205	COG3300	MHYT domain
H4N61_RS12205	COG5001	Diguanylate cyclase
H4N61_RS12210	COG5001	Diguanylate cyclase
H4N61_RS12210	COG3300	MHYT domain
H4N61_RS12215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4N61_RS12215	COG2111	Na H antiporter
H4N61_RS12220	COG1006	Multisubunit Na H antiporter MnhC subunit
H4N61_RS12225	COG0651	ATP synthesis coupled electron transport
H4N61_RS12230	COG1863	multisubunit Na H antiporter MnhE subunit
H4N61_RS12235	COG2212	antiporter activity
H4N61_RS12240	COG1320	monovalent cation:proton antiporter activity
H4N61_RS12245	COG2314	TM2 domain
H4N61_RS12250	COG1414	Transcriptional regulator
H4N61_RS12255	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H4N61_RS12260	COG0573	inorganic phosphate transmembrane transporter activity
H4N61_RS12270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H4N61_RS12275	COG0704	Plays a role in the regulation of phosphate uptake
H4N61_RS12280	COG0745	RESPONSE REGULATOR receiver
H4N61_RS12300	COG1012	belongs to the aldehyde dehydrogenase family
H4N61_RS12315	COG0730	response to heat
H4N61_RS12320	COG0432	Pfam Uncharacterised protein family UPF0047
H4N61_RS12330	COG2862	Uncharacterized protein family, UPF0114
H4N61_RS12355	COG0840	transmembrane signaling receptor activity
H4N61_RS12375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4N61_RS12390	COG2814	Major facilitator Superfamily
H4N61_RS12395	COG3706	GGDEF domain
H4N61_RS12405	COG0505	Belongs to the CarA family
H4N61_RS12415	COG2321	neutral zinc metallopeptidase
H4N61_RS12420	COG0246	Mannitol dehydrogenase
H4N61_RS12425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4N61_RS12445	COG0737	Belongs to the 5'-nucleotidase family
H4N61_RS12450	COG1846	Transcriptional regulator
H4N61_RS12455	COG1764	response to oxidative stress
H4N61_RS12465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H4N61_RS12470	COG0625	glutathione transferase activity
H4N61_RS12480	COG3237	CsbD-like
H4N61_RS12490	COG2133	pyrroloquinoline quinone binding
H4N61_RS12495	COG1597	lipid kinase activity
H4N61_RS12550	COG2226	methyltransferase
H4N61_RS12555	COG1278	Cold shock
H4N61_RS12560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4N61_RS12565	COG0492	ferredoxin-NADP+ reductase activity
H4N61_RS12570	COG0583	DNA-binding transcription factor activity
H4N61_RS12590	COG0436	Aminotransferase
H4N61_RS12600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4N61_RS12605	COG0697	spore germination
H4N61_RS12620	COG1435	thymidine kinase activity
H4N61_RS12625	COG1607	acyl-coa hydrolase
H4N61_RS12665	COG0556	nucleotide-excision repair
H4N61_RS12685	COG2433	Pfam Transposase IS66
H4N61_RS12690	COG3436	PFAM IS66 Orf2 family protein
H4N61_RS12695	COG2963	transposase activity
H4N61_RS12720	COG2852	Protein conserved in bacteria
H4N61_RS12740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H4N61_RS12745	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H4N61_RS12750	COG0583	DNA-binding transcription factor activity
H4N61_RS12775	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS12780	COG0322	excinuclease ABC activity
H4N61_RS12785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4N61_RS12790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H4N61_RS12800	COG0314	molybdopterin synthase activity
H4N61_RS12805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4N61_RS12810	COG1846	Transcriptional regulator
H4N61_RS12830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H4N61_RS12845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H4N61_RS12860	COG0193	aminoacyl-tRNA hydrolase activity
H4N61_RS12865	COG1486	melibiose metabolic process
H4N61_RS12875	COG0012	GTP binding
H4N61_RS12920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4N61_RS12920	COG2857	Cytochrome c1
H4N61_RS12925	COG2857	Cytochrome c1
H4N61_RS12925	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4N61_RS12930	COG0723	plastoquinol--plastocyanin reductase activity
H4N61_RS12935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4N61_RS12940	COG0408	coproporphyrinogen oxidase activity
H4N61_RS12955	COG0617	tRNA 3'-terminal CCA addition
H4N61_RS12970	COG0435	Glutathione S-transferase
H4N61_RS12975	COG0494	nUDIX hydrolase
H4N61_RS13000	COG1522	sequence-specific DNA binding
H4N61_RS13010	COG4166	transmembrane transport
H4N61_RS13015	COG4172	Belongs to the ABC transporter superfamily
H4N61_RS13020	COG0601	transmembrane transport
H4N61_RS13025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4N61_RS13045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H4N61_RS13065	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H4N61_RS13080	COG0402	S-adenosylhomocysteine deaminase activity
H4N61_RS13125	COG2351	hydroxyisourate hydrolase activity
H4N61_RS13145	COG3257	ureidoglycine aminohydrolase activity
H4N61_RS13150	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H4N61_RS13160	COG1877	trehalose-phosphatase activity
H4N61_RS13165	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H4N61_RS13170	COG0513	Belongs to the DEAD box helicase family
H4N61_RS13180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4N61_RS13205	COG0737	Belongs to the 5'-nucleotidase family
H4N61_RS13225	COG3842	ATPase activity
H4N61_RS13240	COG1653	transport
H4N61_RS13245	COG1609	Transcriptional regulator
H4N61_RS13250	COG2897	thiosulfate sulfurtransferase activity
H4N61_RS13260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4N61_RS13285	COG4214	carbohydrate transport
H4N61_RS13290	COG1129	ABC transporter
H4N61_RS13300	COG2188	Transcriptional regulator
H4N61_RS13330	COG1597	lipid kinase activity
H4N61_RS13335	COG3920	Histidine kinase
H4N61_RS13350	COG0784	Response regulator, receiver
H4N61_RS13375	COG4215	(ABC) transporter
H4N61_RS13390	COG1312	Catalyzes the dehydration of D-mannonate
H4N61_RS13395	COG2860	membrane
H4N61_RS13405	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS13415	COG2186	Transcriptional regulator
H4N61_RS13430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4N61_RS13440	COG1280	lysine exporter protein (LysE YggA)
H4N61_RS13455	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4N61_RS13460	COG0567	Dehydrogenase, E1 component
H4N61_RS13465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H4N61_RS13470	COG0045	succinate-CoA ligase (ADP-forming) activity
H4N61_RS13475	COG0039	L-malate dehydrogenase activity
H4N61_RS13480	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H4N61_RS13495	COG4174	ABC transporter (Permease)
H4N61_RS13500	COG4239	(ABC) transporter, permease
H4N61_RS13505	COG4172	Belongs to the ABC transporter superfamily
H4N61_RS13510	COG4166	transmembrane transport
H4N61_RS13555	COG0729	surface antigen
H4N61_RS13560	COG4221	oxidoreductase activity
H4N61_RS13575	COG0625	glutathione transferase activity
H4N61_RS13580	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H4N61_RS13585	COG1509	lysine 2,3-aminomutase activity
H4N61_RS13590	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H4N61_RS13605	COG3458	cephalosporin-C deacetylase activity
H4N61_RS13625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4N61_RS13630	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
H4N61_RS13630	COG0778	Nitroreductase
H4N61_RS13640	COG4139	cobalamin transport
H4N61_RS13645	COG1120	ATPase activity
H4N61_RS13655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4N61_RS13675	COG3040	lipid binding
H4N61_RS13685	COG3328	transposase activity
H4N61_RS13695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4N61_RS13710	COG0438	transferase activity, transferring glycosyl groups
H4N61_RS13720	COG0438	transferase activity, transferring glycosyl groups
H4N61_RS13730	COG0297	glycogen (starch) synthase activity
H4N61_RS13740	COG1216	Glycosyl transferase, family 2
H4N61_RS13750	COG1538	Outer membrane efflux protein
H4N61_RS13755	COG2274	protein secretion by the type I secretion system
H4N61_RS13760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4N61_RS13805	COG4191	Histidine kinase
H4N61_RS13815	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H4N61_RS13820	COG0594	ribonuclease P activity
H4N61_RS13825	COG0706	membrane insertase activity
H4N61_RS13830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H4N61_RS13835	COG0840	transmembrane signaling receptor activity
H4N61_RS13840	COG0519	Catalyzes the synthesis of GMP from XMP
H4N61_RS13845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4N61_RS13850	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H4N61_RS13865	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H4N61_RS13875	COG0823	Involved in the tonB-independent uptake of proteins
H4N61_RS13885	COG0848	biopolymer transport protein
H4N61_RS13895	COG0824	Thioesterase
H4N61_RS13905	COG2255	four-way junction helicase activity
H4N61_RS13915	COG0632	four-way junction helicase activity
H4N61_RS13920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H4N61_RS13925	COG3706	GGDEF domain
H4N61_RS13930	COG0217	transcriptional regulatory protein
H4N61_RS13935	COG1115	amino acid carrier protein
H4N61_RS13940	COG1692	metallophosphoesterase
H4N61_RS13945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H4N61_RS13985	COG0656	L-ascorbic acid biosynthetic process
H4N61_RS13990	COG3588	fructose-bisphosphate aldolase
H4N61_RS14005	COG0483	inositol monophosphate 1-phosphatase activity
H4N61_RS14020	COG2885	chlorophyll binding
H4N61_RS14030	COG0037	tRNA processing
H4N61_RS14035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H4N61_RS14065	COG0640	Transcriptional regulator
H4N61_RS14070	COG1230	cation diffusion facilitator family transporter
H4N61_RS14080	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H4N61_RS14085	COG4208	sulfate ABC transporter
H4N61_RS14090	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H4N61_RS14110	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H4N61_RS14115	COG0280	phosphate acetyltransferase
H4N61_RS14115	COG0281	malic enzyme
H4N61_RS14125	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H4N61_RS14130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4N61_RS14135	COG4172	Belongs to the ABC transporter superfamily
H4N61_RS14145	COG0601	transmembrane transport
H4N61_RS14150	COG0747	negative chemotaxis
H4N61_RS14155	COG1737	Transcriptional regulator
H4N61_RS14160	COG4948	Mandelate Racemase Muconate Lactonizing
H4N61_RS14175	COG1595	DNA-templated transcription, initiation
H4N61_RS14180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4N61_RS14200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H4N61_RS14205	COG1749	Flagellar hook protein flgE
H4N61_RS14235	COG2186	Transcriptional regulator
H4N61_RS14240	COG0601	transmembrane transport
H4N61_RS14245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4N61_RS14255	COG1335	isochorismatase
H4N61_RS14260	COG2814	Major facilitator Superfamily
H4N61_RS14285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4N61_RS14290	COG3842	ATPase activity
H4N61_RS14295	COG1177	transmembrane transport
H4N61_RS14300	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4N61_RS14315	COG2146	nitrite reductase [NAD(P)H] activity
H4N61_RS14330	COG0028	Belongs to the TPP enzyme family
H4N61_RS14335	COG0247	lactate metabolic process
H4N61_RS14335	COG0277	FAD linked oxidase domain protein
H4N61_RS14340	COG2186	Transcriptional regulator
H4N61_RS14345	COG0534	Mate efflux family protein
H4N61_RS14355	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4N61_RS14360	COG1129	ABC transporter
H4N61_RS14375	COG0670	Belongs to the BI1 family
H4N61_RS14380	COG3932	Exopolysaccharide synthesis, ExoD
H4N61_RS14395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4N61_RS14450	COG0346	lactoylglutathione lyase activity
H4N61_RS14460	COG2304	oxidoreductase activity
H4N61_RS14465	COG1595	DNA-templated transcription, initiation
H4N61_RS14475	COG0482	sulfurtransferase activity
H4N61_RS14495	COG1766	The M ring may be actively involved in energy transduction
H4N61_RS14500	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4N61_RS14510	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4N61_RS14515	COG2204	response regulator
H4N61_RS14520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4N61_RS14545	COG0745	RESPONSE REGULATOR receiver
H4N61_RS14555	COG0745	RESPONSE REGULATOR receiver
H4N61_RS14585	COG0564	pseudouridine synthase activity
H4N61_RS14595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4N61_RS14600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4N61_RS14615	COG1295	ribonuclease BN
H4N61_RS14625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4N61_RS14630	COG0697	spore germination
H4N61_RS14635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H4N61_RS14650	COG1178	ABC-type Fe3 transport system permease component
H4N61_RS14655	COG4143	(ABC) transporter
H4N61_RS14665	COG1132	(ABC) transporter
H4N61_RS14670	COG0254	rRNA binding
H4N61_RS14675	COG1742	UPF0060 membrane protein
H4N61_RS14725	COG2900	Belongs to the SlyX family
H4N61_RS14745	COG2814	Major facilitator Superfamily
H4N61_RS14750	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H4N61_RS14755	COG0596	Alpha beta hydrolase
H4N61_RS14760	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H4N61_RS14780	COG2204	response regulator
H4N61_RS14790	COG2989	Protein conserved in bacteria
H4N61_RS14805	COG1522	sequence-specific DNA binding
H4N61_RS14810	COG1794	racemase activity, acting on amino acids and derivatives
H4N61_RS14820	COG0840	transmembrane signaling receptor activity
H4N61_RS14830	COG3750	Belongs to the UPF0335 family
H4N61_RS14840	COG0469	pyruvate kinase activity
H4N61_RS14855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H4N61_RS14860	COG4608	Belongs to the ABC transporter superfamily
H4N61_RS14865	COG0444	Belongs to the ABC transporter superfamily
H4N61_RS14870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4N61_RS14875	COG0601	transmembrane transport
H4N61_RS14885	COG0183	Belongs to the thiolase family
H4N61_RS14895	COG1960	acyl-CoA dehydrogenase activity
H4N61_RS14900	COG0318	PFAM AMP-dependent synthetase and ligase
H4N61_RS14905	COG0789	Transcriptional regulator
H4N61_RS14910	COG0556	nucleotide-excision repair
H4N61_RS14915	COG1793	dna ligase
H4N61_RS14960	COG0667	Aldo Keto reductase
H4N61_RS14965	COG1802	Transcriptional regulator
H4N61_RS14970	COG0673	inositol 2-dehydrogenase activity
H4N61_RS14980	COG1136	(ABC) transporter
H4N61_RS14985	COG1136	(ABC) transporter
H4N61_RS14985	COG0577	efflux transmembrane transporter activity
H4N61_RS15000	COG1643	Atp-dependent helicase
H4N61_RS15005	COG3713	MltA-interacting MipA family protein
H4N61_RS15010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4N61_RS15020	COG4191	Histidine kinase
H4N61_RS15020	COG0784	Response regulator, receiver
H4N61_RS15090	COG0069	glutamate synthase activity
H4N61_RS15090	COG0070	glutamate synthase
H4N61_RS15090	COG0067	glutamate synthase
H4N61_RS15095	COG0071	Belongs to the small heat shock protein (HSP20) family
H4N61_RS15100	COG2721	sulfolactate sulfo-lyase activity
H4N61_RS15105	COG1802	Transcriptional regulator
H4N61_RS15115	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4N61_RS15125	COG0488	(ABC) transporter
H4N61_RS15135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4N61_RS15140	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H4N61_RS15155	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H4N61_RS15165	COG1304	FMN binding
H4N61_RS15185	COG0800	Aldolase
H4N61_RS15220	COG2199	diguanylate cyclase activity
H4N61_RS15235	COG0667	Aldo Keto reductase
H4N61_RS15265	COG2951	lytic endotransglycosylase activity
H4N61_RS15270	COG0668	transmembrane transport
H4N61_RS15305	COG0739	heme binding
H4N61_RS15315	COG0542	response to heat
H4N61_RS15325	COG2890	protein-(glutamine-N5) methyltransferase activity
H4N61_RS15330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H4N61_RS15340	COG0527	aspartate kinase activity
H4N61_RS15345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4N61_RS15360	COG1253	flavin adenine dinucleotide binding
H4N61_RS15365	COG0129	dihydroxy-acid dehydratase activity
H4N61_RS15385	COG1136	(ABC) transporter
H4N61_RS15390	COG4591	ABC-type transport system involved in lipoprotein release permease component
H4N61_RS15395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4N61_RS15405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4N61_RS15410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H4N61_RS15415	COG1040	competence protein
H4N61_RS15425	COG1329	Transcriptional regulator
H4N61_RS15430	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H4N61_RS15455	COG1162	GTPase activity
H4N61_RS15465	COG1278	Cold shock
H4N61_RS15485	COG0625	glutathione transferase activity
H4N61_RS15490	COG2910	NAD(P)H-binding
H4N61_RS15495	COG1733	regulation of RNA biosynthetic process
H4N61_RS15515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H4N61_RS15545	COG0271	Belongs to the BolA IbaG family
H4N61_RS15550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H4N61_RS15555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H4N61_RS15565	COG4974	Belongs to the 'phage' integrase family
H4N61_RS15570	COG0825	malonyl-CoA metabolic process
H4N61_RS15575	COG3034	peptidoglycan biosynthetic process
H4N61_RS15585	COG0653	protein targeting
H4N61_RS15590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4N61_RS15595	COG1309	transcriptional regulator
H4N61_RS15605	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H4N61_RS15615	COG0494	nUDIX hydrolase
H4N61_RS15625	COG4783	chaperone-mediated protein folding
H4N61_RS15635	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H4N61_RS15655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4N61_RS15675	COG2096	Adenosyltransferase
H4N61_RS15690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4N61_RS15695	COG0165	Argininosuccinate lyase
H4N61_RS15705	COG0019	diaminopimelate decarboxylase activity
H4N61_RS15725	COG2884	Cell division ATP-binding protein ftsE
H4N61_RS15745	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H4N61_RS15755	COG0287	Prephenate dehydrogenase
H4N61_RS15760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4N61_RS15770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4N61_RS15795	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H4N61_RS15820	COG0114	fumarate hydratase activity
H4N61_RS15825	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H4N61_RS15850	COG2264	protein methyltransferase activity
H4N61_RS15865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H4N61_RS15880	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H4N61_RS15925	COG1803	Methylglyoxal synthase
H4N61_RS15930	COG0840	transmembrane signaling receptor activity
H4N61_RS15940	COG0840	transmembrane signaling receptor activity
H4N61_RS15945	COG0840	transmembrane signaling receptor activity
H4N61_RS15950	COG0840	transmembrane signaling receptor activity
H4N61_RS15950	COG2972	Histidine kinase
H4N61_RS15955	COG0745	RESPONSE REGULATOR receiver
H4N61_RS15960	COG2201	protein-glutamate methylesterase activity
H4N61_RS15965	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H4N61_RS15970	COG0840	transmembrane signaling receptor activity
H4N61_RS15985	COG0835	chemotaxis
H4N61_RS15990	COG2198	Histidine kinase
H4N61_RS15990	COG0643	Histidine kinase
H4N61_RS15995	COG0745	RESPONSE REGULATOR receiver
H4N61_RS16020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4N61_RS16025	COG2313	pseudouridylate synthase activity
H4N61_RS16030	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H4N61_RS16035	COG3842	ATPase activity
H4N61_RS16040	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4N61_RS16045	COG1177	transmembrane transport
H4N61_RS16055	COG1959	2 iron, 2 sulfur cluster binding
H4N61_RS16060	COG4651	solute:proton antiporter activity
H4N61_RS16060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4N61_RS16065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4N61_RS16075	COG0667	Aldo Keto reductase
H4N61_RS16085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4N61_RS16095	COG2201	protein-glutamate methylesterase activity
H4N61_RS16105	COG0835	chemotaxis
H4N61_RS16110	COG0840	transmembrane signaling receptor activity
H4N61_RS16115	COG0835	chemotaxis
H4N61_RS16120	COG2198	Histidine kinase
H4N61_RS16120	COG0643	Histidine kinase
H4N61_RS16125	COG0745	RESPONSE REGULATOR receiver
H4N61_RS16145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4N61_RS16155	COG4993	Dehydrogenase
H4N61_RS16160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H4N61_RS16170	COG3685	Protein conserved in bacteria
H4N61_RS16175	COG3920	Histidine kinase
H4N61_RS16205	COG1028	Short-chain dehydrogenase reductase Sdr
H4N61_RS16215	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H4N61_RS16225	COG5002	protein histidine kinase activity
H4N61_RS16225	COG5001	Diguanylate cyclase
H4N61_RS16240	COG2963	transposase activity
H4N61_RS16245	COG3436	PFAM IS66 Orf2 family protein
H4N61_RS16310	COG2323	membrane
H4N61_RS16325	COG3685	Protein conserved in bacteria
H4N61_RS16340	COG3459	Glycosyltransferase 36 associated
H4N61_RS16385	COG1802	Transcriptional regulator
H4N61_RS16390	COG1414	Transcriptional regulator
H4N61_RS16395	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4N61_RS16410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4N61_RS16420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4N61_RS16430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4N61_RS16460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H4N61_RS16480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H4N61_RS16495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H4N61_RS16500	COG0799	negative regulation of ribosome biogenesis
H4N61_RS16505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H4N61_RS16515	COG0793	Belongs to the peptidase S41A family
H4N61_RS16525	COG0494	nUDIX hydrolase
H4N61_RS16530	COG1794	racemase activity, acting on amino acids and derivatives
H4N61_RS16535	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H4N61_RS16540	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H4N61_RS16545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H4N61_RS16555	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H4N61_RS16570	COG4974	Belongs to the 'phage' integrase family
H4N61_RS16575	COG0697	spore germination
H4N61_RS16650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H4N61_RS16655	COG2081	HI0933 family
H4N61_RS16665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4N61_RS16675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4N61_RS16685	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H4N61_RS16690	COG2186	Transcriptional regulator
H4N61_RS16700	COG0336	Belongs to the RNA methyltransferase TrmD family
H4N61_RS16705	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H4N61_RS16725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4N61_RS16740	COG0138	bifunctional purine biosynthesis protein purh
H4N61_RS16750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H4N61_RS16750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4N61_RS16755	COG0501	Belongs to the peptidase M48B family
H4N61_RS16770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4N61_RS16780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4N61_RS16785	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4N61_RS16790	COG4133	protoheme IX ABC transporter activity
H4N61_RS16795	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4N61_RS16820	COG0670	Belongs to the BI1 family
H4N61_RS16840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H4N61_RS16845	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H4N61_RS16855	COG5001	Diguanylate cyclase
H4N61_RS16870	COG0586	Pfam SNARE associated Golgi protein
H4N61_RS16880	COG1872	DUF167
H4N61_RS16885	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H4N61_RS16915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4N61_RS16930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H4N61_RS16940	COG0259	pyridoxamine-phosphate oxidase activity
H4N61_RS16945	COG0484	heat shock protein binding
H4N61_RS17020	COG1846	Transcriptional regulator
H4N61_RS17025	COG3038	cytochrome b561
H4N61_RS17035	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H4N61_RS17060	COG0587	DNA-directed DNA polymerase activity
H4N61_RS17065	COG2154	pterin-4-alpha-carbinolamine dehydratase
H4N61_RS17070	COG5001	Diguanylate cyclase
H4N61_RS17100	COG0181	hydroxymethylbilane synthase activity
H4N61_RS17110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H4N61_RS17125	COG2917	probably involved in intracellular septation
H4N61_RS17130	COG0552	protein localization to endoplasmic reticulum
H4N61_RS17135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4N61_RS17140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H4N61_RS17155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H4N61_RS17160	COG0228	four-way junction DNA binding
H4N61_RS17170	COG0473	3-isopropylmalate dehydrogenase activity
H4N61_RS17180	COG0251	oxidation-reduction process
H4N61_RS17190	COG0066	3-isopropylmalate dehydratase activity
H4N61_RS17195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H4N61_RS17200	COG0813	purine-nucleoside phosphorylase activity
H4N61_RS17205	COG0335	large ribosomal subunit rRNA binding
H4N61_RS17220	COG0745	RESPONSE REGULATOR receiver
H4N61_RS17225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H4N61_RS17230	COG0495	leucyl-tRNA aminoacylation
H4N61_RS17250	COG0357	Ribosomal RNA small subunit methyltransferase G
H4N61_RS17255	COG0445	tRNA wobble uridine modification
H4N61_RS17260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H4N61_RS17265	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H4N61_RS17275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H4N61_RS17280	COG0424	maF-like protein
H4N61_RS17285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4N61_RS17290	COG0237	dephospho-CoA kinase activity
H4N61_RS17295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4N61_RS17300	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H4N61_RS17305	COG3030	protein affecting phage T7 exclusion by the F plasmid
H4N61_RS17315	COG2840	Smr protein MutS2
H4N61_RS17325	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H4N61_RS17330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4N61_RS17335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H4N61_RS17340	COG0131	Imidazoleglycerol-phosphate dehydratase
H4N61_RS17345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H4N61_RS17350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H4N61_RS17360	COG0107	imidazoleglycerol-phosphate synthase activity
H4N61_RS17365	COG0140	phosphoribosyl-ATP diphosphatase activity
H4N61_RS17370	COG1072	(Pantothenic acid kinase))
H4N61_RS17385	COG0588	phosphoglycerate mutase activity
H4N61_RS17400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H4N61_RS17405	COG1309	transcriptional regulator
H4N61_RS17410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4N61_RS17415	COG3622	Belongs to the hyi family
H4N61_RS17420	COG0284	orotidine-5'-phosphate decarboxylase activity
H4N61_RS17440	COG0484	heat shock protein binding
H4N61_RS17445	COG0443	Heat shock 70 kDa protein
H4N61_RS17460	COG1335	isochorismatase
H4N61_RS17470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H4N61_RS17480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H4N61_RS17485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H4N61_RS17490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4N61_RS17495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H4N61_RS17500	COG0792	nuclease activity
H4N61_RS17510	COG2095	MarC family integral membrane protein
H4N61_RS17530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4N61_RS17545	COG0330	HflC and HflK could
H4N61_RS17550	COG3757	hydrolase, family 25
H4N61_RS17580	COG2378	regulation of single-species biofilm formation
H4N61_RS17590	COG1609	Transcriptional regulator
H4N61_RS17595	COG1070	Carbohydrate kinase
H4N61_RS17610	COG3507	Belongs to the glycosyl hydrolase 43 family
H4N61_RS17615	COG2873	o-acetylhomoserine
H4N61_RS17625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H4N61_RS17630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H4N61_RS17640	COG0180	Tryptophanyl-tRNA synthetase
H4N61_RS17655	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H4N61_RS17660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H4N61_RS17680	COG0673	inositol 2-dehydrogenase activity
H4N61_RS17690	COG3181	Tripartite tricarboxylate transporter family receptor
H4N61_RS17710	COG1695	Transcriptional regulator
H4N61_RS17735	COG0328	RNA-DNA hybrid ribonuclease activity
H4N61_RS17745	COG3617	BRO family, N-terminal domain
H4N61_RS17760	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H4N61_RS17765	COG1214	PFAM Peptidase M22, glycoprotease
H4N61_RS17790	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H4N61_RS17810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H4N61_RS17815	COG0539	negative regulation of cytoplasmic translation
H4N61_RS17825	COG0776	regulation of translation
H4N61_RS17835	COG0135	phosphoribosylanthranilate isomerase activity
H4N61_RS17845	COG0159	tryptophan synthase activity
H4N61_RS17850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H4N61_RS17855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4N61_RS17870	COG3118	belongs to the thioredoxin family
H4N61_RS17880	COG0285	dihydrofolate synthase activity
H4N61_RS17885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4N61_RS17885	COG0072	phenylalanine-tRNA ligase activity
H4N61_RS17890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H4N61_RS17895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H4N61_RS17905	COG0840	transmembrane signaling receptor activity
H4N61_RS17925	COG0071	Belongs to the small heat shock protein (HSP20) family
H4N61_RS17935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4N61_RS17940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H4N61_RS17945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H4N61_RS17950	COG1137	ATPase activity
H4N61_RS17965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4N61_RS17970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H4N61_RS17975	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H4N61_RS17980	COG0779	Required for maturation of 30S ribosomal subunits
H4N61_RS17995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H4N61_RS18005	COG1388	LysM domain
H4N61_RS18005	COG1376	ErfK ybiS ycfS ynhG family protein
H4N61_RS18020	COG3920	Histidine kinase
H4N61_RS18025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4N61_RS18030	COG1702	phosphate starvation-inducible protein PhoH
H4N61_RS18035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H4N61_RS18040	COG1253	flavin adenine dinucleotide binding
H4N61_RS18045	COG0277	FAD linked oxidase domain protein
H4N61_RS18050	COG0583	DNA-binding transcription factor activity
H4N61_RS18060	COG1175	transmembrane transport
H4N61_RS18065	COG0395	ABC-type sugar transport system, permease component
H4N61_RS18080	COG3842	ATPase activity
H4N61_RS18085	COG0753	catalase activity
H4N61_RS18100	COG3118	belongs to the thioredoxin family
H4N61_RS18110	COG2835	tetraacyldisaccharide 4'-kinase activity
H4N61_RS18115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4N61_RS18120	COG0347	Belongs to the P(II) protein family
H4N61_RS18125	COG0004	ammonium transporteR
H4N61_RS18130	COG0347	Belongs to the P(II) protein family
H4N61_RS18135	COG0004	ammonium transporteR
H4N61_RS18155	COG1968	undecaprenyl-diphosphatase activity
H4N61_RS18165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H4N61_RS18185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H4N61_RS18195	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H4N61_RS18210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4N61_RS18215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H4N61_RS18230	COG0756	dUTP diphosphatase activity
H4N61_RS18240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4N61_RS18245	COG2226	methyltransferase
H4N61_RS18250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H4N61_RS18255	COG0268	Binds directly to 16S ribosomal RNA