locus-tag	class	description
H9K76_RS00005	COG0646	methionine synthase
H9K76_RS00005	COG1410	methionine synthase
H9K76_RS00015	COG3550	peptidyl-serine autophosphorylation
H9K76_RS00020	COG0584	glycerophosphoryl diester phosphodiesterase
H9K76_RS00030	COG0133	tryptophan synthase activity
H9K76_RS00040	COG1301	dicarboxylic acid transport
H9K76_RS00060	COG0747	negative chemotaxis
H9K76_RS00065	COG4608	Belongs to the ABC transporter superfamily
H9K76_RS00075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K76_RS00085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H9K76_RS00150	COG2072	flavoprotein involved in K transport
H9K76_RS00170	COG0583	DNA-binding transcription factor activity
H9K76_RS00175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9K76_RS00175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9K76_RS00195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9K76_RS00230	COG0347	Belongs to the P(II) protein family
H9K76_RS00235	COG0004	ammonium transporteR
H9K76_RS00240	COG3386	PFAM SMP-30 Gluconolaconase
H9K76_RS00250	COG0277	FAD linked oxidase domain protein
H9K76_RS00255	COG0247	lactate metabolic process
H9K76_RS00280	COG0386	Belongs to the glutathione peroxidase family
H9K76_RS00295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9K76_RS00305	COG1858	cytochrome C peroxidase
H9K76_RS00325	COG3845	ABC transporter
H9K76_RS00340	COG1335	isochorismatase
H9K76_RS00395	COG1216	Glycosyl transferase, family 2
H9K76_RS00420	COG0477	Major facilitator Superfamily
H9K76_RS00425	COG2205	protein histidine kinase activity
H9K76_RS00430	COG0745	RESPONSE REGULATOR receiver
H9K76_RS00440	COG2207	Transcriptional regulator
H9K76_RS00440	COG0662	Cupin 2, conserved barrel domain protein
H9K76_RS00445	COG0697	spore germination
H9K76_RS00460	COG4585	Histidine kinase
H9K76_RS00470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9K76_RS00495	COG4628	conserved protein (DUF2132)
H9K76_RS00515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K76_RS00520	COG2188	Transcriptional regulator
H9K76_RS00540	COG2819	hydrolase of the alpha beta superfamily
H9K76_RS00545	COG0708	Exodeoxyribonuclease III
H9K76_RS00550	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9K76_RS00580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9K76_RS00585	COG0154	amidase activity
H9K76_RS00590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9K76_RS00595	COG1077	Cell shape determining protein MreB Mrl
H9K76_RS00610	COG0768	penicillin binding
H9K76_RS00625	COG0765	amino acid transport
H9K76_RS00630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K76_RS00645	COG0004	ammonium transporteR
H9K76_RS00665	COG0277	FAD linked oxidase domain protein
H9K76_RS00665	COG0247	lactate metabolic process
H9K76_RS00685	COG1802	Transcriptional regulator
H9K76_RS00695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9K76_RS00700	COG1127	ABC transporter
H9K76_RS00715	COG0175	sulfate reduction
H9K76_RS00740	COG4452	Inner membrane protein CreD
H9K76_RS00745	COG2205	protein histidine kinase activity
H9K76_RS00750	COG0745	RESPONSE REGULATOR receiver
H9K76_RS00755	COG2095	MarC family integral membrane protein
H9K76_RS00760	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS00765	COG0412	Dienelactone hydrolase
H9K76_RS00770	COG0598	Magnesium transport protein CorA
H9K76_RS00780	COG1981	membrane
H9K76_RS00795	COG2945	thiolester hydrolase activity
H9K76_RS00800	COG1686	Belongs to the peptidase S11 family
H9K76_RS00805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H9K76_RS00810	COG0049	tRNA binding
H9K76_RS00815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9K76_RS00820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9K76_RS00825	COG0051	transcription antitermination factor activity, RNA binding
H9K76_RS00830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9K76_RS00835	COG0088	Forms part of the polypeptide exit tunnel
H9K76_RS00840	COG0089	rRNA binding
H9K76_RS00845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9K76_RS00850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9K76_RS00855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9K76_RS00860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9K76_RS00865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H9K76_RS00870	COG0255	Belongs to the universal ribosomal protein uL29 family
H9K76_RS00875	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9K76_RS00880	COG0678	peroxiredoxin activity
H9K76_RS00895	COG0456	acetyltransferase
H9K76_RS00905	COG3909	cytochrome
H9K76_RS00910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9K76_RS00925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K76_RS00930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9K76_RS00940	COG3604	Transcriptional regulator
H9K76_RS00945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H9K76_RS00950	COG0321	lipoyl(octanoyl) transferase activity
H9K76_RS00955	COG2921	Belongs to the UPF0250 family
H9K76_RS00965	COG0356	it plays a direct role in the translocation of protons across the membrane
H9K76_RS00975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H9K76_RS00980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9K76_RS00985	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9K76_RS00990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9K76_RS00995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9K76_RS01000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H9K76_RS01015	COG1704	LemA family
H9K76_RS01035	COG3245	cytochrome
H9K76_RS01065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9K76_RS01070	COG1414	Transcriptional regulator
H9K76_RS01100	COG0251	oxidation-reduction process
H9K76_RS01105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H9K76_RS01110	COG0583	DNA-binding transcription factor activity
H9K76_RS01130	COG0626	cystathionine gamma-synthase activity
H9K76_RS01155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9K76_RS01210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9K76_RS01215	COG2814	Major facilitator Superfamily
H9K76_RS01220	COG4771	TonB-dependent receptor
H9K76_RS01240	COG0583	DNA-binding transcription factor activity
H9K76_RS01250	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS01255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H9K76_RS01260	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9K76_RS01280	COG3384	dioxygenase
H9K76_RS01285	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9K76_RS01290	COG0583	DNA-binding transcription factor activity
H9K76_RS01315	COG4166	transmembrane transport
H9K76_RS01320	COG0601	transmembrane transport
H9K76_RS01325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K76_RS01330	COG0444	Belongs to the ABC transporter superfamily
H9K76_RS01335	COG4608	Belongs to the ABC transporter superfamily
H9K76_RS01385	COG3040	lipid binding
H9K76_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS01405	COG0121	glutamine amidotransferase
H9K76_RS01415	COG1942	4-Oxalocrotonate Tautomerase
H9K76_RS01435	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS01450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9K76_RS01455	COG1696	Membrane protein involved in D-alanine export
H9K76_RS01475	COG1215	transferase activity, transferring glycosyl groups
H9K76_RS01485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H9K76_RS01495	COG0745	RESPONSE REGULATOR receiver
H9K76_RS01530	COG0018	arginyl-trna synthetase
H9K76_RS01540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9K76_RS01545	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H9K76_RS01550	COG1137	ATPase activity
H9K76_RS01555	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H9K76_RS01575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K76_RS01595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9K76_RS01600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9K76_RS01605	COG1024	Enoyl-CoA hydratase
H9K76_RS01615	COG0069	glutamate synthase activity
H9K76_RS01620	COG0653	protein targeting
H9K76_RS01635	COG1129	ABC transporter
H9K76_RS01640	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS01645	COG1609	Transcriptional regulator
H9K76_RS01650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K76_RS01655	COG1869	D-ribose catabolic process
H9K76_RS01660	COG1546	Belongs to the CinA family
H9K76_RS01665	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H9K76_RS01680	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H9K76_RS01695	COG2967	ApaG domain
H9K76_RS01700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9K76_RS01710	COG0546	phosphoglycolate phosphatase activity
H9K76_RS01720	COG0840	transmembrane signaling receptor activity
H9K76_RS01740	COG0512	Glutamine amidotransferase of anthranilate synthase
H9K76_RS01745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9K76_RS01750	COG0134	indole-3-glycerol-phosphate synthase activity
H9K76_RS01765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H9K76_RS01770	COG0583	DNA-binding transcription factor activity
H9K76_RS01795	COG0563	adenylate kinase activity
H9K76_RS01800	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9K76_RS01805	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H9K76_RS01815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H9K76_RS01820	COG3384	dioxygenase
H9K76_RS01840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9K76_RS01845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9K76_RS01855	COG3842	ATPase activity
H9K76_RS01860	COG3842	ATPase activity
H9K76_RS01870	COG0395	ABC-type sugar transport system, permease component
H9K76_RS01885	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H9K76_RS01890	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9K76_RS01895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9K76_RS01900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9K76_RS01905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9K76_RS01910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9K76_RS01915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9K76_RS01920	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H9K76_RS01925	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H9K76_RS01930	COG1841	ribosomal large subunit assembly
H9K76_RS01935	COG0200	Binds to the 23S rRNA
H9K76_RS01940	COG0201	protein transport
H9K76_RS01945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9K76_RS01950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9K76_RS01955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9K76_RS01960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9K76_RS01965	COG0202	RNA polymerase activity
H9K76_RS01970	COG0203	ribosomal protein L17
H9K76_RS01995	COG0443	Heat shock 70 kDa protein
H9K76_RS02025	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS02045	COG0792	nuclease activity
H9K76_RS02050	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H9K76_RS02055	COG2823	Periplasmic or secreted lipoprotein
H9K76_RS02060	COG2084	Dehydrogenase
H9K76_RS02070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K76_RS02080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H9K76_RS02090	COG0545	Peptidyl-prolyl cis-trans isomerase
H9K76_RS02095	COG2733	membrane
H9K76_RS02110	COG0277	FAD linked oxidase domain protein
H9K76_RS02115	COG0583	DNA-binding transcription factor activity
H9K76_RS02130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9K76_RS02135	COG3945	hemerythrin HHE cation binding domain
H9K76_RS02150	COG1414	Transcriptional regulator
H9K76_RS02190	COG0243	molybdopterin cofactor binding
H9K76_RS02195	COG1473	amidohydrolase
H9K76_RS02215	COG0519	Catalyzes the synthesis of GMP from XMP
H9K76_RS02225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9K76_RS02270	COG1022	Amp-dependent synthetase and ligase
H9K76_RS02275	COG3267	Type II secretory pathway component ExeA
H9K76_RS02275	COG3409	Peptidoglycan-binding domain 1 protein
H9K76_RS02285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K76_RS02290	COG1187	pseudouridine synthase activity
H9K76_RS02300	COG3188	usher protein
H9K76_RS02315	COG0326	Molecular chaperone. Has ATPase activity
H9K76_RS02340	COG2815	serine threonine protein kinase
H9K76_RS02340	COG0515	serine threonine protein kinase
H9K76_RS02350	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K76_RS02360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9K76_RS02365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H9K76_RS02370	COG1490	D-aminoacyl-tRNA deacylase activity
H9K76_RS02390	COG0583	DNA-binding transcription factor activity
H9K76_RS02395	COG0730	response to heat
H9K76_RS02400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9K76_RS02405	COG1702	phosphate starvation-inducible protein PhoH
H9K76_RS02410	COG0632	four-way junction helicase activity
H9K76_RS02425	COG0443	Heat shock 70 kDa protein
H9K76_RS02435	COG0443	Heat shock 70 kDa protein
H9K76_RS02450	COG4770	biotin carboxylase activity
H9K76_RS02455	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H9K76_RS02460	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H9K76_RS02480	COG1802	Transcriptional regulator
H9K76_RS02485	COG2255	four-way junction helicase activity
H9K76_RS02520	COG3616	Alanine racemase, N-terminal domain
H9K76_RS02540	COG0037	tRNA processing
H9K76_RS02550	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS02575	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H9K76_RS02580	COG3387	PFAM Glycoside hydrolase 15-related
H9K76_RS02600	COG0617	tRNA 3'-terminal CCA addition
H9K76_RS02605	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K76_RS02615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H9K76_RS02620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9K76_RS02635	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS02655	COG3128	pkhd-type hydroxylase
H9K76_RS02660	COG4774	siderophore transport
H9K76_RS02665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9K76_RS02675	COG3186	Phenylalanine-4-hydroxylase
H9K76_RS02690	COG1522	sequence-specific DNA binding
H9K76_RS02700	COG4535	Mg2 and Co2 transporter CorC
H9K76_RS02705	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H9K76_RS02710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9K76_RS02720	COG0752	glycyl-tRNA synthetase alpha subunit
H9K76_RS02725	COG0751	glycine-tRNA ligase activity
H9K76_RS02730	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9K76_RS02750	COG1652	LysM domain
H9K76_RS02755	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H9K76_RS02775	COG1091	dTDP-4-dehydrorhamnose reductase activity
H9K76_RS02795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9K76_RS02800	COG1459	type II secretion system
H9K76_RS02805	COG2165	general secretion pathway protein
H9K76_RS02810	COG4969	Belongs to the N-Me-Phe pilin family
H9K76_RS02815	COG2165	general secretion pathway protein
H9K76_RS02845	COG1450	Type ii and iii secretion system protein
H9K76_RS02860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9K76_RS02880	COG2226	methyltransferase
H9K76_RS02910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9K76_RS02915	COG0745	RESPONSE REGULATOR receiver
H9K76_RS02925	COG1309	transcriptional regulator
H9K76_RS02945	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K76_RS02945	COG1024	Enoyl-CoA hydratase
H9K76_RS02950	COG0183	Belongs to the thiolase family
H9K76_RS02960	COG1024	Enoyl-CoA hydratase
H9K76_RS02980	COG5265	(ABC) transporter
H9K76_RS02985	COG0022	dehydrogenase e1 component
H9K76_RS02985	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9K76_RS02990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H9K76_RS03000	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H9K76_RS03000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H9K76_RS03010	COG0583	DNA-binding transcription factor activity
H9K76_RS03025	COG0765	amino acid transport
H9K76_RS03030	COG0765	amino acid transport
H9K76_RS03035	COG1126	abc transporter atp-binding protein
H9K76_RS03040	COG2755	lipolytic protein G-D-S-L family
H9K76_RS03040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H9K76_RS03065	COG2076	Multidrug Resistance protein
H9K76_RS03080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H9K76_RS03090	COG2814	Major facilitator Superfamily
H9K76_RS03100	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H9K76_RS03105	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H9K76_RS03110	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H9K76_RS03115	COG2205	protein histidine kinase activity
H9K76_RS03125	COG2875	Belongs to the precorrin methyltransferase family
H9K76_RS03140	COG2099	Precorrin-6x reductase
H9K76_RS03165	COG0745	RESPONSE REGULATOR receiver
H9K76_RS03170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H9K76_RS03180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H9K76_RS03190	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H9K76_RS03195	COG0515	serine threonine protein kinase
H9K76_RS03200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9K76_RS03205	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9K76_RS03210	COG0316	Belongs to the HesB IscA family
H9K76_RS03215	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H9K76_RS03225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9K76_RS03230	COG0583	DNA-binding transcription factor activity
H9K76_RS03240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H9K76_RS03255	COG1522	sequence-specific DNA binding
H9K76_RS03270	COG0243	molybdopterin cofactor binding
H9K76_RS03290	COG2204	response regulator
H9K76_RS03310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9K76_RS03315	COG0798	PFAM Bile acid sodium symporter
H9K76_RS03325	COG0431	NADPH-dependent FMN reductase
H9K76_RS03345	COG2205	protein histidine kinase activity
H9K76_RS03345	COG2198	Histidine kinase
H9K76_RS03345	COG0784	Response regulator, receiver
H9K76_RS03350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H9K76_RS03390	COG1538	Outer membrane efflux protein
H9K76_RS03395	COG2274	protein secretion by the type I secretion system
H9K76_RS03400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K76_RS03410	COG0693	protein deglycase activity
H9K76_RS03415	COG0745	RESPONSE REGULATOR receiver
H9K76_RS03425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9K76_RS03435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9K76_RS03440	COG3045	CreA protein
H9K76_RS03445	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9K76_RS03445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9K76_RS03450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9K76_RS03450	COG0189	ligase activity
H9K76_RS03455	COG1132	(ABC) transporter
H9K76_RS03475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9K76_RS03525	COG4970	Tfp pilus assembly protein FimT
H9K76_RS03545	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H9K76_RS03550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H9K76_RS03555	COG1765	OsmC-like protein
H9K76_RS03575	COG1473	amidohydrolase
H9K76_RS03580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K76_RS03585	COG0444	Belongs to the ABC transporter superfamily
H9K76_RS03590	COG4608	Belongs to the ABC transporter superfamily
H9K76_RS03595	COG0737	Belongs to the 5'-nucleotidase family
H9K76_RS03600	COG1881	PFAM PEBP family protein
H9K76_RS03610	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H9K76_RS03615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9K76_RS03620	COG0166	Belongs to the GPI family
H9K76_RS03625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K76_RS03630	COG0459	protein refolding
H9K76_RS03635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H9K76_RS03640	COG0420	3'-5' exonuclease activity
H9K76_RS03645	COG0419	ATPase involved in DNA repair
H9K76_RS03695	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H9K76_RS03720	COG0702	epimerase
H9K76_RS03745	COG0438	transferase activity, transferring glycosyl groups
H9K76_RS03760	COG1051	belongs to the nudix hydrolase family
H9K76_RS03760	COG1056	cytidyltransferase-related domain
H9K76_RS03765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H9K76_RS03765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9K76_RS03770	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H9K76_RS03790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9K76_RS03795	COG1560	Kdo2-lipid A biosynthetic process
H9K76_RS03800	COG1560	Kdo2-lipid A biosynthetic process
H9K76_RS03815	COG1333	cytochrome c biogenesis protein
H9K76_RS03820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9K76_RS03825	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H9K76_RS03830	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H9K76_RS03840	COG1965	Belongs to the frataxin family
H9K76_RS03875	COG2373	Large extracellular alpha-helical protein
H9K76_RS03875	COG1388	LysM domain
H9K76_RS03875	COG4932	domain protein
H9K76_RS03885	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H9K76_RS03920	COG0067	glutamate synthase
H9K76_RS03920	COG0070	glutamate synthase
H9K76_RS03920	COG0069	glutamate synthase activity
H9K76_RS03950	COG0516	GMP reductase activity
H9K76_RS03955	COG0210	DNA helicase
H9K76_RS04000	COG2885	chlorophyll binding
H9K76_RS04015	COG0697	spore germination
H9K76_RS04025	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H9K76_RS04030	COG0583	DNA-binding transcription factor activity
H9K76_RS04045	COG1473	amidohydrolase
H9K76_RS04050	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H9K76_RS04075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H9K76_RS04080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9K76_RS04085	COG0196	riboflavin kinase activity
H9K76_RS04095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K76_RS04100	COG1045	serine acetyltransferase
H9K76_RS04110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K76_RS04115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9K76_RS04135	COG2010	Cytochrome c
H9K76_RS04135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H9K76_RS04150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9K76_RS04180	COG0559	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS04185	COG0411	ABC transporter
H9K76_RS04200	COG2873	o-acetylhomoserine
H9K76_RS04215	COG1116	anion transmembrane transporter activity
H9K76_RS04220	COG1464	Belongs to the NlpA lipoprotein family
H9K76_RS04230	COG2011	ABC-type metal ion transport system permease component
H9K76_RS04235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9K76_RS04240	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS04245	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS04250	COG3132	Protein of unknown function, DUF480
H9K76_RS04255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H9K76_RS04270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9K76_RS04270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9K76_RS04285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9K76_RS04290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9K76_RS04295	COG0492	ferredoxin-NADP+ reductase activity
H9K76_RS04300	COG1674	ftsk spoiiie
H9K76_RS04305	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H9K76_RS04320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9K76_RS04325	COG0559	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS04355	COG1392	Phosphate transport regulator
H9K76_RS04360	COG0306	phosphate transporter
H9K76_RS04375	COG0228	four-way junction DNA binding
H9K76_RS04380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9K76_RS04385	COG0336	Belongs to the RNA methyltransferase TrmD family
H9K76_RS04390	COG0335	large ribosomal subunit rRNA binding
H9K76_RS04405	COG0745	RESPONSE REGULATOR receiver
H9K76_RS04415	COG2205	protein histidine kinase activity
H9K76_RS04425	COG2154	pterin-4-alpha-carbinolamine dehydratase
H9K76_RS04430	COG0501	Belongs to the peptidase M48B family
H9K76_RS04435	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H9K76_RS04440	COG0513	Belongs to the DEAD box helicase family
H9K76_RS04445	COG2814	Major facilitator Superfamily
H9K76_RS04460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K76_RS04465	COG0765	amino acid transport
H9K76_RS04470	COG1126	abc transporter atp-binding protein
H9K76_RS04475	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H9K76_RS04480	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H9K76_RS04485	COG1127	ABC transporter
H9K76_RS04490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9K76_RS04495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H9K76_RS04515	COG1131	(ABC) transporter
H9K76_RS04520	COG0842	Transport permease protein
H9K76_RS04530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9K76_RS04535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H9K76_RS04560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9K76_RS04565	COG0131	Imidazoleglycerol-phosphate dehydratase
H9K76_RS04575	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H9K76_RS04580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9K76_RS04590	COG0107	imidazoleglycerol-phosphate synthase activity
H9K76_RS04605	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H9K76_RS04610	COG0140	phosphoribosyl-ATP diphosphatase activity
H9K76_RS04625	COG0537	adenosine 5'-monophosphoramidase activity
H9K76_RS04630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9K76_RS04635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9K76_RS04640	COG0805	protein transport
H9K76_RS04655	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H9K76_RS04660	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H9K76_RS04665	COG1970	mechanosensitive ion channel activity
H9K76_RS04670	COG0723	plastoquinol--plastocyanin reductase activity
H9K76_RS04675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H9K76_RS04680	COG2857	Cytochrome c1
H9K76_RS04685	COG0625	glutathione transferase activity
H9K76_RS04690	COG2969	positive regulation of protein catabolic process
H9K76_RS04705	COG0653	protein targeting
H9K76_RS04720	COG0494	nUDIX hydrolase
H9K76_RS04725	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H9K76_RS04730	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H9K76_RS04760	COG2129	metallophosphoesterase
H9K76_RS04770	COG0142	geranyltranstransferase activity
H9K76_RS04775	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9K76_RS04780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H9K76_RS04785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9K76_RS04790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H9K76_RS04800	COG0442	prolyl-tRNA aminoacylation
H9K76_RS04805	COG0741	lytic transglycosylase activity
H9K76_RS04810	COG1253	flavin adenine dinucleotide binding
H9K76_RS04815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H9K76_RS04820	COG2890	protein-(glutamine-N5) methyltransferase activity
H9K76_RS04830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9K76_RS04835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H9K76_RS04845	COG1846	Transcriptional regulator
H9K76_RS04850	COG2375	cellular response to nickel ion
H9K76_RS04855	COG1196	nuclear chromosome segregation
H9K76_RS04855	COG3264	Mechanosensitive ion channel
H9K76_RS04860	COG0584	glycerophosphoryl diester phosphodiesterase
H9K76_RS04865	COG3842	ATPase activity
H9K76_RS04870	COG0395	ABC-type sugar transport system, permease component
H9K76_RS04880	COG1653	transport
H9K76_RS04885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9K76_RS04890	COG0431	NADPH-dependent FMN reductase
H9K76_RS04905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9K76_RS04910	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS04930	COG2226	methyltransferase
H9K76_RS04945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H9K76_RS04965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9K76_RS04990	COG3655	Transcriptional regulator
H9K76_RS05000	COG0302	gtp cyclohydrolase
H9K76_RS05030	COG1024	Enoyl-CoA hydratase
H9K76_RS05040	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS05050	COG1280	lysine exporter protein (LysE YggA)
H9K76_RS05055	COG0154	amidase activity
H9K76_RS05065	COG4608	Belongs to the ABC transporter superfamily
H9K76_RS05070	COG0444	Belongs to the ABC transporter superfamily
H9K76_RS05075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K76_RS05080	COG0601	transmembrane transport
H9K76_RS05085	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9K76_RS05090	COG0193	aminoacyl-tRNA hydrolase activity
H9K76_RS05095	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H9K76_RS05100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9K76_RS05110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H9K76_RS05125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9K76_RS05135	COG1194	a g-specific adenine glycosylase
H9K76_RS05140	COG1660	Displays ATPase and GTPase activities
H9K76_RS05145	COG0497	DNA recombination
H9K76_RS05150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H9K76_RS05155	COG1420	regulation of RNA biosynthetic process
H9K76_RS05180	COG0582	viral genome integration into host DNA
H9K76_RS05235	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS05240	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS05245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H9K76_RS05255	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9K76_RS05265	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H9K76_RS05270	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H9K76_RS05290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9K76_RS05310	COG1116	anion transmembrane transporter activity
H9K76_RS05315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9K76_RS05320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9K76_RS05325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9K76_RS05330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9K76_RS05355	COG2205	protein histidine kinase activity
H9K76_RS05355	COG2198	Histidine kinase
H9K76_RS05355	COG0784	Response regulator, receiver
H9K76_RS05360	COG2197	response regulator
H9K76_RS05370	COG2271	Major facilitator Superfamily
H9K76_RS05375	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS05380	COG1012	belongs to the aldehyde dehydrogenase family
H9K76_RS05385	COG1414	Transcriptional regulator
H9K76_RS05415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9K76_RS05420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9K76_RS05435	COG2815	serine threonine protein kinase
H9K76_RS05435	COG0515	serine threonine protein kinase
H9K76_RS05440	COG1561	YicC-like family, N-terminal region
H9K76_RS05445	COG0194	GDP metabolic process
H9K76_RS05450	COG1758	RNA polymerase activity
H9K76_RS05455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9K76_RS05475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H9K76_RS05480	COG1185	polyribonucleotide nucleotidyltransferase activity
H9K76_RS05485	COG0604	alcohol dehydrogenase
H9K76_RS05485	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS05485	COG3321	synthase
H9K76_RS05490	COG0149	triose-phosphate isomerase activity
H9K76_RS05505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9K76_RS05510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9K76_RS05515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9K76_RS05520	COG0649	NAD binding
H9K76_RS05535	COG1034	ATP synthesis coupled electron transport
H9K76_RS05540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H9K76_RS05545	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9K76_RS05555	COG0713	ATP synthesis coupled electron transport
H9K76_RS05570	COG1007	ATP synthesis coupled electron transport
H9K76_RS05600	COG0673	inositol 2-dehydrogenase activity
H9K76_RS05625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K76_RS05630	COG1280	lysine exporter protein (LysE YggA)
H9K76_RS05635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H9K76_RS05645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9K76_RS05650	COG0586	Pfam SNARE associated Golgi protein
H9K76_RS05665	COG0860	N-Acetylmuramoyl-L-alanine amidase
H9K76_RS05670	COG0802	atpase or kinase
H9K76_RS05675	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9K76_RS05685	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS05690	COG4974	Belongs to the 'phage' integrase family
H9K76_RS05700	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H9K76_RS05705	COG2833	Protein of unknown function (DUF455)
H9K76_RS05725	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H9K76_RS05730	COG0148	phosphopyruvate hydratase activity
H9K76_RS05740	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H9K76_RS05745	COG0504	CTP synthase activity
H9K76_RS05780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K76_RS05785	COG0577	efflux transmembrane transporter activity
H9K76_RS05785	COG1136	(ABC) transporter
H9K76_RS05790	COG1538	Outer membrane efflux protein
H9K76_RS05795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H9K76_RS05805	COG0756	dUTP diphosphatase activity
H9K76_RS05815	COG1047	Peptidyl-prolyl cis-trans
H9K76_RS05820	COG2850	peptidyl-arginine hydroxylation
H9K76_RS05835	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H9K76_RS05840	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H9K76_RS05845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9K76_RS05870	COG0741	lytic transglycosylase activity
H9K76_RS05880	COG2329	Antibiotic biosynthesis monooxygenase
H9K76_RS05885	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H9K76_RS05900	COG2308	Evidence 4 Homologs of previously reported genes of
H9K76_RS05935	COG1722	exodeoxyribonuclease VII activity
H9K76_RS05945	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9K76_RS05950	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H9K76_RS05965	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H9K76_RS06015	COG4191	Histidine kinase
H9K76_RS06015	COG0784	Response regulator, receiver
H9K76_RS06035	COG1136	(ABC) transporter
H9K76_RS06035	COG0577	efflux transmembrane transporter activity
H9K76_RS06040	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9K76_RS06045	COG0537	adenosine 5'-monophosphoramidase activity
H9K76_RS06055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K76_RS06070	COG5002	protein histidine kinase activity
H9K76_RS06070	COG3447	MASE1 domain protein
H9K76_RS06070	COG5001	Diguanylate cyclase
H9K76_RS06075	COG2814	Major facilitator Superfamily
H9K76_RS06080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H9K76_RS06095	COG3845	ABC transporter
H9K76_RS06100	COG4603	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS06105	COG1079	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS06130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9K76_RS06145	COG3483	tryptophan 2,3-dioxygenase activity
H9K76_RS06155	COG1620	l-lactate permease
H9K76_RS06160	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H9K76_RS06165	COG0727	PFAM Uncharacterised protein family (UPF0153)
H9K76_RS06195	COG0727	PFAM Uncharacterised protein family (UPF0153)
H9K76_RS06205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9K76_RS06210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H9K76_RS06225	COG0268	Binds directly to 16S ribosomal RNA
H9K76_RS06230	COG0728	peptidoglycan biosynthetic process
H9K76_RS06245	COG0589	response to stress
H9K76_RS06255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9K76_RS06260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9K76_RS06270	COG0617	tRNA 3'-terminal CCA addition
H9K76_RS06275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9K76_RS06290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9K76_RS06290	COG0543	2 iron, 2 sulfur cluster binding
H9K76_RS06310	COG0583	DNA-binding transcription factor activity
H9K76_RS06315	COG2910	NAD(P)H-binding
H9K76_RS06330	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS06335	COG0583	DNA-binding transcription factor activity
H9K76_RS06355	COG0583	DNA-binding transcription factor activity
H9K76_RS06360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K76_RS06420	COG3209	COG3209 Rhs family protein
H9K76_RS06440	COG2816	NAD+ diphosphatase activity
H9K76_RS06445	COG0425	Belongs to the sulfur carrier protein TusA family
H9K76_RS06450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K76_RS06455	COG0697	spore germination
H9K76_RS06465	COG0525	valine-tRNA ligase activity
H9K76_RS06490	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS06495	COG0604	alcohol dehydrogenase
H9K76_RS06505	COG0583	DNA-binding transcription factor activity
H9K76_RS06540	COG0181	hydroxymethylbilane synthase activity
H9K76_RS06545	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H9K76_RS06550	COG0456	acetyltransferase
H9K76_RS06580	COG0450	alkyl hydroperoxide reductase
H9K76_RS06585	COG3634	alkyl hydroperoxide reductase activity
H9K76_RS06595	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H9K76_RS06650	COG4558	Periplasmic binding protein
H9K76_RS06655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K76_RS06660	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H9K76_RS06675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H9K76_RS06690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9K76_RS06710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H9K76_RS06735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9K76_RS06740	COG0358	DNA primase activity
H9K76_RS06745	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS06755	COG2814	Major facilitator Superfamily
H9K76_RS06760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9K76_RS06770	COG0405	Gamma-glutamyltransferase
H9K76_RS06775	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H9K76_RS06775	COG3608	succinylglutamate desuccinylase aspartoacylase
H9K76_RS06820	COG0483	inositol monophosphate 1-phosphatase activity
H9K76_RS06830	COG1045	serine acetyltransferase
H9K76_RS06840	COG1858	cytochrome C peroxidase
H9K76_RS06850	COG0584	glycerophosphoryl diester phosphodiesterase
H9K76_RS06855	COG0521	Mo-molybdopterin cofactor biosynthetic process
H9K76_RS06860	COG3028	Belongs to the UPF0307 family
H9K76_RS06865	COG0312	modulator of DNA gyrase
H9K76_RS06890	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9K76_RS06900	COG2233	PERMEase
H9K76_RS06915	COG2223	nitrite transmembrane transporter activity
H9K76_RS06920	COG0473	3-isopropylmalate dehydrogenase activity
H9K76_RS06925	COG0583	DNA-binding transcription factor activity
H9K76_RS06930	COG5006	permease, DMT superfamily
H9K76_RS06935	COG1522	sequence-specific DNA binding
H9K76_RS06945	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H9K76_RS06955	COG2081	HI0933 family
H9K76_RS06965	COG1607	acyl-coa hydrolase
H9K76_RS06985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9K76_RS06990	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS06995	COG2223	nitrite transmembrane transporter activity
H9K76_RS07010	COG0583	DNA-binding transcription factor activity
H9K76_RS07025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K76_RS07035	COG2205	protein histidine kinase activity
H9K76_RS07040	COG0745	RESPONSE REGULATOR receiver
H9K76_RS07060	COG0516	GMP reductase activity
H9K76_RS07060	COG0517	IMP dehydrogenase activity
H9K76_RS07085	COG0683	leucine binding
H9K76_RS07090	COG2951	lytic endotransglycosylase activity
H9K76_RS07105	COG0714	Associated with various cellular activities
H9K76_RS07110	COG0123	including yeast histone deacetylase and acetoin utilization protein
H9K76_RS07115	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K76_RS07115	COG1024	Enoyl-CoA hydratase
H9K76_RS07120	COG3264	Mechanosensitive ion channel
H9K76_RS07120	COG1196	nuclear chromosome segregation
H9K76_RS07135	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS07140	COG2070	2-Nitropropane dioxygenase
H9K76_RS07155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K76_RS07170	COG0583	DNA-binding transcription factor activity
H9K76_RS07175	COG2133	pyrroloquinoline quinone binding
H9K76_RS07180	COG0417	DNA replication proofreading
H9K76_RS07210	COG4988	ABC transporter
H9K76_RS07215	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H9K76_RS07225	COG1294	oxidase, subunit
H9K76_RS07240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K76_RS07250	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H9K76_RS07255	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H9K76_RS07275	COG2205	protein histidine kinase activity
H9K76_RS07285	COG0372	Belongs to the citrate synthase family
H9K76_RS07290	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H9K76_RS07295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9K76_RS07300	COG1053	succinate dehydrogenase
H9K76_RS07310	COG2009	succinate dehydrogenase
H9K76_RS07315	COG2188	Transcriptional regulator
H9K76_RS07320	COG0039	L-malate dehydrogenase activity
H9K76_RS07350	COG0583	DNA-binding transcription factor activity
H9K76_RS07355	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS07365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9K76_RS07375	COG0826	peptidase U32
H9K76_RS07385	COG2954	triphosphatase activity
H9K76_RS07390	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H9K76_RS07405	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H9K76_RS07410	COG1845	cytochrome c oxidase, subunit III
H9K76_RS07415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H9K76_RS07420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9K76_RS07425	COG0477	Major facilitator Superfamily
H9K76_RS07445	COG0824	Thioesterase
H9K76_RS07450	COG0436	Aminotransferase
H9K76_RS07455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9K76_RS07460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H9K76_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS07480	COG2918	glutathione biosynthetic process
H9K76_RS07490	COG1752	Esterase of the alpha-beta hydrolase superfamily
H9K76_RS07500	COG0028	Belongs to the TPP enzyme family
H9K76_RS07515	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H9K76_RS07530	COG0564	pseudouridine synthase activity
H9K76_RS07560	COG3064	Membrane
H9K76_RS07565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9K76_RS07570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9K76_RS07575	COG0670	Belongs to the BI1 family
H9K76_RS07580	COG3193	protein, possibly involved in utilization of glycolate and propanediol
H9K76_RS07615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9K76_RS07635	COG1858	cytochrome C peroxidase
H9K76_RS07645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9K76_RS07650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H9K76_RS07655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9K76_RS07660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H9K76_RS07665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9K76_RS07670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K76_RS07670	COG0072	phenylalanine-tRNA ligase activity
H9K76_RS07675	COG0776	regulation of translation
H9K76_RS07680	COG0789	Transcriptional regulator
H9K76_RS07690	COG1683	Conserved Protein
H9K76_RS07720	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H9K76_RS07725	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H9K76_RS07735	COG0583	DNA-binding transcription factor activity
H9K76_RS07755	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS07765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H9K76_RS07785	COG0583	DNA-binding transcription factor activity
H9K76_RS07795	COG0697	spore germination
H9K76_RS07800	COG1335	isochorismatase
H9K76_RS07805	COG0583	DNA-binding transcription factor activity
H9K76_RS07810	COG1280	lysine exporter protein (LysE YggA)
H9K76_RS07815	COG3971	2-oxopent-4-enoate hydratase activity
H9K76_RS07820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H9K76_RS07825	COG1846	Transcriptional regulator
H9K76_RS07875	COG0778	Nitroreductase
H9K76_RS07880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9K76_RS07890	COG0346	lactoylglutathione lyase activity
H9K76_RS07895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9K76_RS07920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H9K76_RS07940	COG1024	Enoyl-CoA hydratase
H9K76_RS07940	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K76_RS07945	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H9K76_RS07950	COG0439	Biotin carboxylase
H9K76_RS07970	COG2084	Dehydrogenase
H9K76_RS07975	COG1012	belongs to the aldehyde dehydrogenase family
H9K76_RS08000	COG4177	L-phenylalanine transmembrane transporter activity
H9K76_RS08025	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9K76_RS08040	COG1012	belongs to the aldehyde dehydrogenase family
H9K76_RS08050	COG3384	dioxygenase
H9K76_RS08060	COG3971	2-oxopent-4-enoate hydratase activity
H9K76_RS08075	COG1846	Transcriptional regulator
H9K76_RS08085	COG1012	belongs to the aldehyde dehydrogenase family
H9K76_RS08095	COG5441	Belongs to the UPF0261 family
H9K76_RS08135	COG4585	Histidine kinase
H9K76_RS08165	COG2197	response regulator
H9K76_RS08170	COG1285	pathogenesis
H9K76_RS08220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9K76_RS08225	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9K76_RS08230	COG1309	transcriptional regulator
H9K76_RS08235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H9K76_RS08240	COG0022	dehydrogenase e1 component
H9K76_RS08250	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9K76_RS08255	COG0095	Lipoate-protein ligase
H9K76_RS08270	COG2267	carboxylic ester hydrolase activity
H9K76_RS08275	COG3284	Transcriptional regulator
H9K76_RS08285	COG2824	Alkylphosphonate utilization operon protein PhnA
H9K76_RS08295	COG0402	S-adenosylhomocysteine deaminase activity
H9K76_RS08300	COG0251	oxidation-reduction process
H9K76_RS08305	COG0583	DNA-binding transcription factor activity
H9K76_RS08335	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS08340	COG3246	L-lysine catabolic process to acetate
H9K76_RS08370	COG0789	Transcriptional regulator
H9K76_RS08400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K76_RS08405	COG0243	molybdopterin cofactor binding
H9K76_RS08410	COG1271	oxidase subunit
H9K76_RS08415	COG1294	oxidase, subunit
H9K76_RS08420	COG3781	membrane
H9K76_RS08425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H9K76_RS08435	COG3042	response to heat
H9K76_RS08440	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H9K76_RS08455	COG2814	Major facilitator Superfamily
H9K76_RS08460	COG1309	transcriptional regulator
H9K76_RS08480	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H9K76_RS08480	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H9K76_RS08485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9K76_RS08535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9K76_RS08545	COG4566	intracellular signal transduction
H9K76_RS08575	COG2188	Transcriptional regulator
H9K76_RS08620	COG2205	protein histidine kinase activity
H9K76_RS08625	COG4106	trans-aconitate 2-methyltransferase activity
H9K76_RS08630	COG0505	Belongs to the CarA family
H9K76_RS08635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9K76_RS08640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K76_RS08655	COG1534	Rna-binding protein
H9K76_RS08660	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H9K76_RS08665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9K76_RS08675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9K76_RS08685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9K76_RS08700	COG0248	Ppx GppA phosphatase
H9K76_RS08710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H9K76_RS08715	COG0573	inorganic phosphate transmembrane transporter activity
H9K76_RS08720	COG0581	inorganic phosphate transmembrane transporter activity
H9K76_RS08725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9K76_RS08730	COG0704	Plays a role in the regulation of phosphate uptake
H9K76_RS08735	COG0745	RESPONSE REGULATOR receiver
H9K76_RS08745	COG0534	Mate efflux family protein
H9K76_RS08755	COG0254	rRNA binding
H9K76_RS08760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H9K76_RS08765	COG3118	belongs to the thioredoxin family
H9K76_RS08775	COG1074	ATP-dependent DNA helicase activity
H9K76_RS08780	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
H9K76_RS08790	COG2271	Major facilitator Superfamily
H9K76_RS08795	COG2186	Transcriptional regulator
H9K76_RS08830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H9K76_RS08835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9K76_RS08845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9K76_RS08855	COG1388	LysM domain
H9K76_RS08855	COG0741	lytic transglycosylase activity
H9K76_RS08860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9K76_RS08865	COG2226	methyltransferase
H9K76_RS08870	COG0328	RNA-DNA hybrid ribonuclease activity
H9K76_RS08890	COG0746	molybdenum cofactor guanylyltransferase activity
H9K76_RS08895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H9K76_RS08910	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H9K76_RS08915	COG0835	chemotaxis
H9K76_RS08930	COG0347	Belongs to the P(II) protein family
H9K76_RS08940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9K76_RS08965	COG0028	Belongs to the TPP enzyme family
H9K76_RS08970	COG0440	acetolactate synthase activity
H9K76_RS08975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H9K76_RS08980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9K76_RS08990	COG1414	Transcriptional regulator
H9K76_RS08995	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H9K76_RS09000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H9K76_RS09015	COG3842	ATPase activity
H9K76_RS09035	COG0724	RNA recognition motif
H9K76_RS09040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9K76_RS09055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9K76_RS09085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9K76_RS09090	COG2011	ABC-type metal ion transport system permease component
H9K76_RS09120	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS09125	COG1268	BioY protein
H9K76_RS09135	COG1122	ATPase activity
H9K76_RS09145	COG1346	cytolysis
H9K76_RS09150	COG0513	Belongs to the DEAD box helicase family
H9K76_RS09155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9K76_RS09165	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H9K76_RS09170	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H9K76_RS09175	COG4208	sulfate ABC transporter
H9K76_RS09180	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H9K76_RS09185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H9K76_RS09200	COG0251	oxidation-reduction process
H9K76_RS09205	COG2186	Transcriptional regulator
H9K76_RS09220	COG1126	abc transporter atp-binding protein
H9K76_RS09245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K76_RS09250	COG0251	oxidation-reduction process
H9K76_RS09260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H9K76_RS09265	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
H9K76_RS09270	COG0745	RESPONSE REGULATOR receiver
H9K76_RS09275	COG5002	protein histidine kinase activity
H9K76_RS09290	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS09295	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H9K76_RS09295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9K76_RS09300	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H9K76_RS09300	COG2755	lipolytic protein G-D-S-L family
H9K76_RS09310	COG3829	transcription factor binding
H9K76_RS09325	COG3275	phosphorelay sensor kinase activity
H9K76_RS09330	COG3279	Response regulator of the LytR AlgR family
H9K76_RS09335	COG2828	Protein conserved in bacteria
H9K76_RS09360	COG0640	Transcriptional regulator
H9K76_RS09365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9K76_RS09390	COG1764	response to oxidative stress
H9K76_RS09395	COG1846	Transcriptional regulator
H9K76_RS09405	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS09410	COG1793	dna ligase
H9K76_RS09410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H9K76_RS09415	COG1793	dna ligase
H9K76_RS09420	COG1201	RNA secondary structure unwinding
H9K76_RS09435	COG0778	Nitroreductase
H9K76_RS09450	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H9K76_RS09455	COG1595	DNA-templated transcription, initiation
H9K76_RS09460	COG3842	ATPase activity
H9K76_RS09475	COG0667	Aldo Keto reductase
H9K76_RS09485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9K76_RS09490	COG0235	Class ii aldolase
H9K76_RS09495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9K76_RS09510	COG0579	oxidoreductase
H9K76_RS09530	COG0167	dihydroorotate dehydrogenase activity
H9K76_RS09535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H9K76_RS09550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9K76_RS09555	COG4566	intracellular signal transduction
H9K76_RS09570	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9K76_RS09575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9K76_RS09585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9K76_RS09605	COG0587	DNA-directed DNA polymerase activity
H9K76_RS09630	COG2197	response regulator
H9K76_RS09635	COG4585	Histidine kinase
H9K76_RS09640	COG2982	Protein involved in outer membrane biogenesis
H9K76_RS09715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K76_RS09715	COG2205	protein histidine kinase activity
H9K76_RS09725	COG1012	belongs to the aldehyde dehydrogenase family
H9K76_RS09730	COG2205	protein histidine kinase activity
H9K76_RS09730	COG0784	Response regulator, receiver
H9K76_RS09730	COG5002	protein histidine kinase activity
H9K76_RS09775	COG3474	cytochrome
H9K76_RS09790	COG0456	acetyltransferase
H9K76_RS09800	COG1132	(ABC) transporter
H9K76_RS09800	COG2375	cellular response to nickel ion
H9K76_RS09805	COG1132	(ABC) transporter
H9K76_RS09810	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K76_RS09815	COG4605	iron ion homeostasis
H9K76_RS09820	COG4604	ABC transporter, ATP-binding protein
H9K76_RS09825	COG4607	ABC-type enterochelin transport system periplasmic component
H9K76_RS09830	COG4774	siderophore transport
H9K76_RS09850	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H9K76_RS09855	COG1233	COG1233 Phytoene dehydrogenase and related
H9K76_RS09885	COG0129	dihydroxy-acid dehydratase activity
H9K76_RS09890	COG0583	DNA-binding transcription factor activity
H9K76_RS09905	COG0251	oxidation-reduction process
H9K76_RS09930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9K76_RS09945	COG0583	DNA-binding transcription factor activity
H9K76_RS09990	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS10005	COG2070	2-Nitropropane dioxygenase
H9K76_RS10035	COG1414	Transcriptional regulator
H9K76_RS10050	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS10055	COG1012	belongs to the aldehyde dehydrogenase family
H9K76_RS10060	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS10065	COG0183	Belongs to the thiolase family
H9K76_RS10070	COG1414	Transcriptional regulator
H9K76_RS10085	COG0183	Belongs to the thiolase family
H9K76_RS10115	COG1022	Amp-dependent synthetase and ligase
H9K76_RS10140	COG3135	benzoate transporter
H9K76_RS10175	COG0559	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS10190	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS10200	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS10205	COG1280	lysine exporter protein (LysE YggA)
H9K76_RS10215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9K76_RS10220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9K76_RS10235	COG0436	Aminotransferase
H9K76_RS10245	COG0765	amino acid transport
H9K76_RS10250	COG1126	abc transporter atp-binding protein
H9K76_RS10260	COG0511	ligase activity, forming carbon-carbon bonds
H9K76_RS10270	COG1984	allophanate hydrolase subunit 2
H9K76_RS10275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H9K76_RS10280	COG0511	ligase activity, forming carbon-carbon bonds
H9K76_RS10300	COG5377	YqaJ viral recombinase family
H9K76_RS10350	COG4166	transmembrane transport
H9K76_RS10355	COG4174	ABC transporter (Permease)
H9K76_RS10365	COG4239	(ABC) transporter, permease
H9K76_RS10370	COG4172	Belongs to the ABC transporter superfamily
H9K76_RS10375	COG0596	Alpha beta hydrolase
H9K76_RS10380	COG0589	response to stress
H9K76_RS10385	COG0583	DNA-binding transcription factor activity
H9K76_RS10400	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS10405	COG0628	permease
H9K76_RS10410	COG0567	Dehydrogenase, E1 component
H9K76_RS10415	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9K76_RS10420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9K76_RS10425	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H9K76_RS10440	COG1199	ATP-dependent helicase activity
H9K76_RS10455	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H9K76_RS10460	COG0542	response to heat
H9K76_RS10470	COG2951	lytic endotransglycosylase activity
H9K76_RS10475	COG2925	Exonuclease
H9K76_RS10480	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9K76_RS10485	COG0628	permease
H9K76_RS10495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9K76_RS10505	COG2271	Major facilitator Superfamily
H9K76_RS10520	COG0625	glutathione transferase activity
H9K76_RS10525	COG0433	COG0433 Predicted ATPase
H9K76_RS10530	COG0217	transcriptional regulatory protein
H9K76_RS10535	COG0151	Belongs to the GarS family
H9K76_RS10540	COG0408	coproporphyrinogen oxidase activity
H9K76_RS10545	COG0799	negative regulation of ribosome biogenesis
H9K76_RS10550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9K76_RS10555	COG0424	maF-like protein
H9K76_RS10560	COG1530	ribonuclease E activity
H9K76_RS10565	COG2197	response regulator
H9K76_RS10570	COG0436	Aminotransferase
H9K76_RS10575	COG0583	DNA-binding transcription factor activity
H9K76_RS10595	COG1477	protein flavinylation
H9K76_RS10600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H9K76_RS10620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9K76_RS10640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9K76_RS10655	COG0589	response to stress
H9K76_RS10670	COG0183	Belongs to the thiolase family
H9K76_RS10675	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS10695	COG0559	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS10705	COG0564	pseudouridine synthase activity
H9K76_RS10710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9K76_RS10710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9K76_RS10720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H9K76_RS10725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H9K76_RS10725	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H9K76_RS10735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H9K76_RS10745	COG0833	amino acid
H9K76_RS10765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H9K76_RS10795	COG4120	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS10815	COG0745	RESPONSE REGULATOR receiver
H9K76_RS10835	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H9K76_RS10840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K76_RS10850	COG0753	catalase activity
H9K76_RS10855	COG1252	NADH dehydrogenase
H9K76_RS10885	COG1012	belongs to the aldehyde dehydrogenase family
H9K76_RS10905	COG0791	NLP P60 protein
H9K76_RS10930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9K76_RS10950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9K76_RS10950	COG0045	succinate-CoA ligase (ADP-forming) activity
H9K76_RS10950	COG1042	CoA-binding domain protein
H9K76_RS10965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9K76_RS10970	COG1309	transcriptional regulator
H9K76_RS10975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K76_RS11000	COG0259	pyridoxamine-phosphate oxidase activity
H9K76_RS11005	COG2032	superoxide dismutase activity
H9K76_RS11025	COG3265	gluconokinase activity
H9K76_RS11030	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H9K76_RS11035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H9K76_RS11040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H9K76_RS11045	COG0129	dihydroxy-acid dehydratase activity
H9K76_RS11050	COG0800	Aldolase
H9K76_RS11055	COG0346	lactoylglutathione lyase activity
H9K76_RS11060	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS11065	COG0697	spore germination
H9K76_RS11080	COG4585	Histidine kinase
H9K76_RS11100	COG1609	Transcriptional regulator
H9K76_RS11105	COG2233	PERMEase
H9K76_RS11120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H9K76_RS11125	COG2719	SpoVR family
H9K76_RS11135	COG2766	serine protein kinase
H9K76_RS11160	COG1024	Enoyl-CoA hydratase
H9K76_RS11160	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K76_RS11175	COG0583	DNA-binding transcription factor activity
H9K76_RS11190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9K76_RS11195	COG1703	isobutyryl-CoA mutase activity
H9K76_RS11200	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9K76_RS11200	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9K76_RS11205	COG1802	Transcriptional regulator
H9K76_RS11210	COG1022	Amp-dependent synthetase and ligase
H9K76_RS11245	COG2878	Part of a membrane complex involved in electron transport
H9K76_RS11255	COG2171	N-acyltransferase activity
H9K76_RS11265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9K76_RS11270	COG2890	protein-(glutamine-N5) methyltransferase activity
H9K76_RS11280	COG0488	(ABC) transporter
H9K76_RS11285	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS11290	COG0183	Belongs to the thiolase family
H9K76_RS11295	COG3243	poly(R)-hydroxyalkanoic acid synthase
H9K76_RS11330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9K76_RS11340	COG1196	nuclear chromosome segregation
H9K76_RS11345	COG1742	UPF0060 membrane protein
H9K76_RS11355	COG1132	(ABC) transporter
H9K76_RS11360	COG2814	Major facilitator Superfamily
H9K76_RS11365	COG1113	amino acid transport
H9K76_RS11385	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS11420	COG3171	Protein conserved in bacteria
H9K76_RS11425	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H9K76_RS11430	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H9K76_RS11435	COG1741	Belongs to the pirin family
H9K76_RS11440	COG0583	DNA-binding transcription factor activity
H9K76_RS11445	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H9K76_RS11445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K76_RS11450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9K76_RS11455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9K76_RS11465	COG0583	DNA-binding transcription factor activity
H9K76_RS11475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9K76_RS11480	COG1012	belongs to the aldehyde dehydrogenase family
H9K76_RS11520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9K76_RS11525	COG0633	Ferredoxin
H9K76_RS11540	COG0316	Belongs to the HesB IscA family
H9K76_RS11545	COG0822	iron-sulfur transferase activity
H9K76_RS11550	COG1104	cysteine desulfurase activity
H9K76_RS11555	COG1959	2 iron, 2 sulfur cluster binding
H9K76_RS11560	COG0556	nucleotide-excision repair
H9K76_RS11570	COG3384	dioxygenase
H9K76_RS11575	COG1802	Transcriptional regulator
H9K76_RS11675	COG4774	siderophore transport
H9K76_RS11685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K76_RS11690	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H9K76_RS11715	COG1739	Uncharacterized protein family UPF0029
H9K76_RS11720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9K76_RS11730	COG3550	peptidyl-serine autophosphorylation
H9K76_RS11765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9K76_RS11770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9K76_RS11785	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H9K76_RS11790	COG4181	ATPase activity
H9K76_RS11800	COG0626	cystathionine gamma-synthase activity
H9K76_RS11805	COG2823	Periplasmic or secreted lipoprotein
H9K76_RS11810	COG0659	secondary active sulfate transmembrane transporter activity
H9K76_RS11815	COG1054	Belongs to the UPF0176 family
H9K76_RS11820	COG1741	Belongs to the pirin family
H9K76_RS11850	COG0217	transcriptional regulatory protein
H9K76_RS11865	COG2301	Belongs to the HpcH HpaI aldolase family
H9K76_RS11880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H9K76_RS11885	COG2252	PERMEase
H9K76_RS11900	COG1619	proteins homologs of microcin C7 resistance protein MccF
H9K76_RS11915	COG2271	Major facilitator Superfamily
H9K76_RS11940	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS11950	COG1012	belongs to the aldehyde dehydrogenase family
H9K76_RS11955	COG0028	Belongs to the TPP enzyme family
H9K76_RS11985	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
H9K76_RS11990	COG1414	Transcriptional regulator
H9K76_RS12005	COG0826	peptidase U32
H9K76_RS12020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H9K76_RS12025	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H9K76_RS12030	COG3047	cAMP biosynthetic process
H9K76_RS12035	COG2354	Protein conserved in bacteria
H9K76_RS12040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9K76_RS12040	COG0047	phosphoribosylformylglycinamidine synthase activity
H9K76_RS12075	COG0242	peptide deformylase activity
H9K76_RS12080	COG2832	Protein of unknown function (DUF454)
H9K76_RS12145	COG0667	Aldo Keto reductase
H9K76_RS12150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H9K76_RS12160	COG0811	peptide transport
H9K76_RS12165	COG0848	biopolymer transport protein
H9K76_RS12170	COG1663	tetraacyldisaccharide 4'-kinase activity
H9K76_RS12175	COG2835	tetraacyldisaccharide 4'-kinase activity
H9K76_RS12180	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H9K76_RS12185	COG0563	adenylate kinase activity
H9K76_RS12195	COG0252	asparaginase activity
H9K76_RS12200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9K76_RS12220	COG3781	membrane
H9K76_RS12225	COG1643	Atp-dependent helicase
H9K76_RS12240	COG2814	Major facilitator Superfamily
H9K76_RS12245	COG2204	response regulator
H9K76_RS12250	COG3852	Histidine kinase
H9K76_RS12260	COG1090	epimerase
H9K76_RS12275	COG0488	(ABC) transporter
H9K76_RS12285	COG0583	DNA-binding transcription factor activity
H9K76_RS12290	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H9K76_RS12300	COG1733	regulation of RNA biosynthetic process
H9K76_RS12305	COG0604	alcohol dehydrogenase
H9K76_RS12305	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS12305	COG3321	synthase
H9K76_RS12330	COG0438	transferase activity, transferring glycosyl groups
H9K76_RS12335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H9K76_RS12350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H9K76_RS12360	COG2885	chlorophyll binding
H9K76_RS12365	COG0823	Involved in the tonB-independent uptake of proteins
H9K76_RS12370	COG1132	(ABC) transporter
H9K76_RS12380	COG0084	hydrolase, TatD family'
H9K76_RS12390	COG0470	DNA polymerase III
H9K76_RS12395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9K76_RS12400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H9K76_RS12420	COG0657	acetylesterase activity
H9K76_RS12435	COG0583	DNA-binding transcription factor activity
H9K76_RS12460	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H9K76_RS12475	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS12485	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS12490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H9K76_RS12500	COG0583	DNA-binding transcription factor activity
H9K76_RS12505	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H9K76_RS12505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K76_RS12525	COG2895	sulfate adenylyltransferase (ATP) activity
H9K76_RS12530	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H9K76_RS12535	COG0492	ferredoxin-NADP+ reductase activity
H9K76_RS12540	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS12550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9K76_RS12555	COG1116	anion transmembrane transporter activity
H9K76_RS12585	COG0351	phosphomethylpyrimidine kinase
H9K76_RS12600	COG2022	thiamine diphosphate biosynthetic process
H9K76_RS12610	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K76_RS12615	COG1024	Enoyl-CoA hydratase
H9K76_RS12645	COG2183	response to ionizing radiation
H9K76_RS12665	COG2814	Major facilitator Superfamily
H9K76_RS12680	COG2153	protein acetylation
H9K76_RS12710	COG2807	transmembrane transport
H9K76_RS12720	COG3842	ATPase activity
H9K76_RS12730	COG1840	ABC-type Fe3 transport system, periplasmic component
H9K76_RS12735	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS12755	COG0183	Belongs to the thiolase family
H9K76_RS12760	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K76_RS12760	COG1024	Enoyl-CoA hydratase
H9K76_RS12770	COG1522	sequence-specific DNA binding
H9K76_RS12775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9K76_RS12780	COG1122	ATPase activity
H9K76_RS12785	COG0411	ABC transporter
H9K76_RS12795	COG0559	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS12800	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS12805	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H9K76_RS12810	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K76_RS12815	COG2917	probably involved in intracellular septation
H9K76_RS12825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9K76_RS12850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9K76_RS12855	COG1125	glycine betaine transport
H9K76_RS12855	COG0517	IMP dehydrogenase activity
H9K76_RS12860	COG0688	phosphatidylethanolamine metabolic process
H9K76_RS12920	COG4804	nuclease activity
H9K76_RS12970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9K76_RS12985	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H9K76_RS12990	COG0077	Prephenate dehydratase
H9K76_RS12990	COG1605	Chorismate mutase
H9K76_RS12995	COG0287	Prephenate dehydrogenase
H9K76_RS13000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H9K76_RS13010	COG0776	regulation of translation
H9K76_RS13020	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H9K76_RS13025	COG1555	photosystem II stabilization
H9K76_RS13025	COG1596	polysaccharide export
H9K76_RS13030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H9K76_RS13030	COG2111	Na H antiporter
H9K76_RS13035	COG1006	Multisubunit Na H antiporter MnhC subunit
H9K76_RS13040	COG0651	ATP synthesis coupled electron transport
H9K76_RS13050	COG2212	antiporter activity
H9K76_RS13055	COG1320	monovalent cation:proton antiporter activity
H9K76_RS13080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9K76_RS13085	COG1611	Belongs to the LOG family
H9K76_RS13105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9K76_RS13115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H9K76_RS13120	COG0824	Thioesterase
H9K76_RS13180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9K76_RS13205	COG0285	dihydrofolate synthase activity
H9K76_RS13210	COG1393	Belongs to the ArsC family
H9K76_RS13220	COG3123	guanosine phosphorylase activity
H9K76_RS13225	COG0137	argininosuccinate synthase activity
H9K76_RS13230	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS13240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9K76_RS13245	COG1666	GTP binding
H9K76_RS13260	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H9K76_RS13265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H9K76_RS13270	COG0667	Aldo Keto reductase
H9K76_RS13280	COG2084	Dehydrogenase
H9K76_RS13290	COG2721	sulfolactate sulfo-lyase activity
H9K76_RS13295	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS13300	COG4948	Mandelate Racemase Muconate Lactonizing
H9K76_RS13310	COG1802	Transcriptional regulator
H9K76_RS13315	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS13320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9K76_RS13325	COG4948	Mandelate Racemase Muconate Lactonizing
H9K76_RS13340	COG0308	aminopeptidase N
H9K76_RS13345	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H9K76_RS13355	COG0784	Response regulator, receiver
H9K76_RS13355	COG4191	Histidine kinase
H9K76_RS13360	COG3237	CsbD-like
H9K76_RS13385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9K76_RS13385	COG2010	Cytochrome c
H9K76_RS13390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H9K76_RS13445	COG3712	iron ion homeostasis
H9K76_RS13460	COG0477	Major facilitator Superfamily
H9K76_RS13500	COG0583	DNA-binding transcription factor activity
H9K76_RS13525	COG0243	molybdopterin cofactor binding
H9K76_RS13530	COG3043	anaerobic respiration
H9K76_RS13535	COG3005	denitrification pathway
H9K76_RS13540	COG4133	protoheme IX ABC transporter activity
H9K76_RS13570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9K76_RS13575	COG3088	subunit of a heme lyase
H9K76_RS13590	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
H9K76_RS13595	COG3604	Transcriptional regulator
H9K76_RS13600	COG0583	DNA-binding transcription factor activity
H9K76_RS13620	COG3246	L-lysine catabolic process to acetate
H9K76_RS13625	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS13635	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS13640	COG3246	L-lysine catabolic process to acetate
H9K76_RS13655	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS13675	COG2175	clavaminate synthase activity
H9K76_RS13695	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS13720	COG3246	L-lysine catabolic process to acetate
H9K76_RS13725	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9K76_RS13760	COG1595	DNA-templated transcription, initiation
H9K76_RS13770	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K76_RS13775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K76_RS13830	COG0582	viral genome integration into host DNA
H9K76_RS13835	COG4983	Phage plasmid primase, P4 family domain protein
H9K76_RS13855	COG2205	protein histidine kinase activity
H9K76_RS13855	COG2198	Histidine kinase
H9K76_RS13855	COG0784	Response regulator, receiver
H9K76_RS13865	COG0789	Transcriptional regulator
H9K76_RS13870	COG1090	epimerase
H9K76_RS13875	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H9K76_RS13985	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS14070	COG2801	Transposase and inactivated derivatives
H9K76_RS14075	COG2801	Transposase and inactivated derivatives
H9K76_RS14115	COG2207	Transcriptional regulator
H9K76_RS14165	COG5377	YqaJ viral recombinase family
H9K76_RS14195	COG3344	reverse transcriptase
H9K76_RS14235	COG0527	aspartate kinase activity
H9K76_RS14240	COG0037	tRNA processing
H9K76_RS14255	COG0215	cysteine-tRNA ligase activity
H9K76_RS14275	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K76_RS14285	COG3622	Belongs to the hyi family
H9K76_RS14290	COG0235	Class ii aldolase
H9K76_RS14295	COG3395	kinase activity
H9K76_RS14300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9K76_RS14305	COG2084	Dehydrogenase
H9K76_RS14310	COG2271	Major facilitator Superfamily
H9K76_RS14325	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS14335	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H9K76_RS14340	COG1522	sequence-specific DNA binding
H9K76_RS14350	COG2079	MmgE PrpD family protein
H9K76_RS14360	COG0583	DNA-binding transcription factor activity
H9K76_RS14370	COG0583	DNA-binding transcription factor activity
H9K76_RS14385	COG1228	amidohydrolase
H9K76_RS14405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H9K76_RS14425	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H9K76_RS14425	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H9K76_RS14425	COG0506	proline dehydrogenase activity
H9K76_RS14430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9K76_RS14480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K76_RS14505	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS14510	COG1024	Enoyl-CoA hydratase
H9K76_RS14530	COG0163	prenyltransferase activity
H9K76_RS14540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H9K76_RS14550	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H9K76_RS14560	COG1609	Transcriptional regulator
H9K76_RS14620	COG1595	DNA-templated transcription, initiation
H9K76_RS14640	COG0583	DNA-binding transcription factor activity
H9K76_RS14650	COG0519	Catalyzes the synthesis of GMP from XMP
H9K76_RS14650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9K76_RS14680	COG2867	negative regulation of translational initiation
H9K76_RS14685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H9K76_RS14705	COG2151	metal-sulfur cluster biosynthetic enzyme
H9K76_RS14710	COG3396	Phenylacetate-CoA oxygenase
H9K76_RS14715	COG3460	Phenylacetate-CoA oxygenase
H9K76_RS14720	COG3396	Phenylacetate-CoA oxygenase
H9K76_RS14730	COG2050	protein possibly involved in aromatic compounds catabolism
H9K76_RS14735	COG1024	Enoyl-CoA hydratase
H9K76_RS14745	COG1309	transcriptional regulator
H9K76_RS14750	COG1024	Enoyl-CoA hydratase
H9K76_RS14785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9K76_RS14790	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9K76_RS14795	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9K76_RS14800	COG0195	Participates in both transcription termination and antitermination
H9K76_RS14805	COG0779	Required for maturation of 30S ribosomal subunits
H9K76_RS14815	COG2010	Cytochrome c
H9K76_RS14815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H9K76_RS14825	COG4221	oxidoreductase activity
H9K76_RS14830	COG0557	exoribonuclease II activity
H9K76_RS14860	COG0741	lytic transglycosylase activity
H9K76_RS14865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9K76_RS14870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9K76_RS14880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H9K76_RS14885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9K76_RS14890	COG0372	Belongs to the citrate synthase family
H9K76_RS14895	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H9K76_RS14915	COG1011	Hydrolase
H9K76_RS14920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H9K76_RS14925	COG0625	glutathione transferase activity
H9K76_RS14970	COG4177	L-phenylalanine transmembrane transporter activity
H9K76_RS14980	COG1129	ABC transporter
H9K76_RS14990	COG2204	response regulator
H9K76_RS14995	COG2391	methyltransferase activity
H9K76_RS15000	COG0737	Belongs to the 5'-nucleotidase family
H9K76_RS15025	COG4654	Cytochrome c, class I
H9K76_RS15030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H9K76_RS15070	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS15115	COG1566	PFAM secretion protein HlyD family protein
H9K76_RS15120	COG2814	Major facilitator Superfamily
H9K76_RS15135	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS15160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K76_RS15180	COG2863	cytochrome
H9K76_RS15190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9K76_RS15195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9K76_RS15200	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K76_RS15205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K76_RS15210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9K76_RS15215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K76_RS15230	COG0750	zinc metalloprotease
H9K76_RS15235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H9K76_RS15240	COG0575	Belongs to the CDS family
H9K76_RS15245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9K76_RS15250	COG0233	cytoplasmic translational termination
H9K76_RS15255	COG0528	UMP kinase activity
H9K76_RS15260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9K76_RS15265	COG0052	Belongs to the universal ribosomal protein uS2 family
H9K76_RS15270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K76_RS15275	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H9K76_RS15275	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H9K76_RS15300	COG0789	Transcriptional regulator
H9K76_RS15330	COG2132	Multicopper oxidase
H9K76_RS15355	COG1464	Belongs to the NlpA lipoprotein family
H9K76_RS15365	COG3191	aminopeptidase activity
H9K76_RS15380	COG0488	(ABC) transporter
H9K76_RS15385	COG0513	Belongs to the DEAD box helicase family
H9K76_RS15400	COG0582	viral genome integration into host DNA
H9K76_RS15460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9K76_RS15465	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS15490	COG0625	glutathione transferase activity
H9K76_RS15505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9K76_RS15520	COG0028	Belongs to the TPP enzyme family
H9K76_RS15525	COG0346	lactoylglutathione lyase activity
H9K76_RS15535	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H9K76_RS15540	COG1595	DNA-templated transcription, initiation
H9K76_RS15550	COG0154	amidase activity
H9K76_RS15560	COG2186	Transcriptional regulator
H9K76_RS15565	COG0477	Major facilitator Superfamily
H9K76_RS15580	COG0183	Belongs to the thiolase family
H9K76_RS15585	COG4221	oxidoreductase activity
H9K76_RS15605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9K76_RS15605	COG2169	Transcriptional regulator
H9K76_RS15635	COG0183	Belongs to the thiolase family
H9K76_RS15640	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K76_RS15640	COG1024	Enoyl-CoA hydratase
H9K76_RS15665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9K76_RS15675	COG0776	regulation of translation
H9K76_RS15685	COG0322	excinuclease ABC activity
H9K76_RS15695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9K76_RS15700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9K76_RS15715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9K76_RS15720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9K76_RS15725	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H9K76_RS15750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9K76_RS15755	COG0596	Alpha beta hydrolase
H9K76_RS15760	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS15780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H9K76_RS15785	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H9K76_RS15785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9K76_RS15790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H9K76_RS15800	COG0560	Phosphoserine phosphatase
H9K76_RS15810	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H9K76_RS15825	COG0583	DNA-binding transcription factor activity
H9K76_RS15835	COG1840	ABC-type Fe3 transport system, periplasmic component
H9K76_RS15840	COG3842	ATPase activity
H9K76_RS15865	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS15880	COG0667	Aldo Keto reductase
H9K76_RS15885	COG2900	Belongs to the SlyX family
H9K76_RS15890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K76_RS15895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H9K76_RS15900	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H9K76_RS15905	COG1492	cobalamin metabolic process
H9K76_RS15915	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H9K76_RS15920	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H9K76_RS15930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K76_RS15935	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H9K76_RS15945	COG4206	TonB-dependent receptor
H9K76_RS15970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K76_RS16005	COG3278	Belongs to the heme-copper respiratory oxidase family
H9K76_RS16015	COG2217	Heavy metal translocating P-type atpase
H9K76_RS16025	COG1137	ATPase activity
H9K76_RS16040	COG0559	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS16060	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS16065	COG1024	Enoyl-CoA hydratase
H9K76_RS16080	COG1802	Transcriptional regulator
H9K76_RS16085	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9K76_RS16105	COG0129	dihydroxy-acid dehydratase activity
H9K76_RS16115	COG4654	Cytochrome c, class I
H9K76_RS16125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9K76_RS16155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9K76_RS16165	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
H9K76_RS16175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9K76_RS16180	COG4175	Glycine betaine
H9K76_RS16185	COG4176	ABC-type proline glycine betaine transport system permease component
H9K76_RS16190	COG2113	Glycine betaine
H9K76_RS16195	COG2113	Glycine betaine
H9K76_RS16200	COG2205	protein histidine kinase activity
H9K76_RS16205	COG0745	RESPONSE REGULATOR receiver
H9K76_RS16210	COG0114	fumarate hydratase activity
H9K76_RS16220	COG3657	addiction module killer protein
H9K76_RS16265	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H9K76_RS16275	COG0154	amidase activity
H9K76_RS16280	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H9K76_RS16295	COG0431	NADPH-dependent FMN reductase
H9K76_RS16315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H9K76_RS16320	COG1451	nucleotide metabolic process
H9K76_RS16350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H9K76_RS16355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H9K76_RS16360	COG0740	serine-type endopeptidase activity
H9K76_RS16365	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9K76_RS16385	COG4774	siderophore transport
H9K76_RS16400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K76_RS16405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K76_RS16410	COG1562	ergosterol biosynthetic process
H9K76_RS16415	COG0560	Phosphoserine phosphatase
H9K76_RS16425	COG3842	ATPase activity
H9K76_RS16430	COG1178	ABC-type Fe3 transport system permease component
H9K76_RS16435	COG1840	ABC-type Fe3 transport system, periplasmic component
H9K76_RS16455	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H9K76_RS16460	COG1295	ribonuclease BN
H9K76_RS16470	COG0277	FAD linked oxidase domain protein
H9K76_RS16480	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H9K76_RS16490	COG0708	Exodeoxyribonuclease III
H9K76_RS16500	COG1595	DNA-templated transcription, initiation
H9K76_RS16510	COG2204	response regulator
H9K76_RS16515	COG3852	Histidine kinase
H9K76_RS16525	COG0174	glutamine synthetase
H9K76_RS16555	COG1187	pseudouridine synthase activity
H9K76_RS16560	COG2010	Cytochrome c
H9K76_RS16560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H9K76_RS16565	COG2080	2 iron, 2 sulfur cluster binding
H9K76_RS16570	COG1846	Transcriptional regulator
H9K76_RS16580	COG0411	ABC transporter
H9K76_RS16625	COG1309	transcriptional regulator
H9K76_RS16660	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H9K76_RS16665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9K76_RS16670	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H9K76_RS16680	COG0330	HflC and HflK could
H9K76_RS16685	COG0330	HflC and HflK could
H9K76_RS16690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9K76_RS16695	COG1923	regulation of RNA biosynthetic process
H9K76_RS16700	COG1160	GTP binding
H9K76_RS16715	COG0124	histidyl-tRNA synthetase
H9K76_RS16720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H9K76_RS16735	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9K76_RS16740	COG0105	UTP biosynthetic process
H9K76_RS16745	COG1187	pseudouridine synthase activity
H9K76_RS16750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H9K76_RS16755	COG0564	pseudouridine synthase activity
H9K76_RS16765	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9K76_RS16770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H9K76_RS16775	COG3540	Alkaline phosphatase
H9K76_RS16780	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9K76_RS16790	COG3275	phosphorelay sensor kinase activity
H9K76_RS16810	COG0165	Argininosuccinate lyase
H9K76_RS16825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K76_RS16845	COG1968	undecaprenyl-diphosphatase activity
H9K76_RS16855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9K76_RS16860	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H9K76_RS16865	COG2916	Histone family protein nucleoid-structuring protein H-NS
H9K76_RS16870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H9K76_RS16875	COG0513	Belongs to the DEAD box helicase family
H9K76_RS16880	COG2321	neutral zinc metallopeptidase
H9K76_RS16885	COG0717	Belongs to the dCTP deaminase family
H9K76_RS16890	COG0402	S-adenosylhomocysteine deaminase activity
H9K76_RS16925	COG2186	Transcriptional regulator
H9K76_RS16950	COG2159	amidohydrolase
H9K76_RS16970	COG0583	DNA-binding transcription factor activity
H9K76_RS16975	COG2814	Major facilitator Superfamily
H9K76_RS16980	COG2233	PERMEase
H9K76_RS16985	COG0281	malic enzyme
H9K76_RS16985	COG0280	phosphate acetyltransferase
H9K76_RS17000	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS17020	COG3038	cytochrome b561
H9K76_RS17085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H9K76_RS17095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K76_RS17100	COG5441	Belongs to the UPF0261 family
H9K76_RS17105	COG5564	TIM-barrel signal transduction protein
H9K76_RS17120	COG0542	response to heat
H9K76_RS17130	COG0314	molybdopterin synthase activity
H9K76_RS17145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9K76_RS17155	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H9K76_RS17160	COG0303	'Molybdopterin
H9K76_RS17165	COG1763	Mo-molybdopterin cofactor biosynthetic process
H9K76_RS17185	COG0436	Aminotransferase
H9K76_RS17195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9K76_RS17200	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H9K76_RS17210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9K76_RS17215	COG0305	Participates in initiation and elongation during chromosome replication
H9K76_RS17220	COG0359	binds to the 23S rRNA
H9K76_RS17225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H9K76_RS17230	COG2965	DNA replication, synthesis of RNA primer
H9K76_RS17235	COG0360	Binds together with S18 to 16S ribosomal RNA
H9K76_RS17240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9K76_RS17245	COG0443	Heat shock 70 kDa protein
H9K76_RS17250	COG0484	heat shock protein binding
H9K76_RS17255	COG1297	OPT oligopeptide transporter protein
H9K76_RS17265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H9K76_RS17275	COG0066	3-isopropylmalate dehydratase activity
H9K76_RS17280	COG0473	3-isopropylmalate dehydrogenase activity
H9K76_RS17285	COG3422	double-strand break repair
H9K76_RS17290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9K76_RS17300	COG0101	tRNA pseudouridine synthase activity
H9K76_RS17305	COG0135	phosphoribosylanthranilate isomerase activity
H9K76_RS17310	COG0133	tryptophan synthase activity
H9K76_RS17315	COG0159	tryptophan synthase activity
H9K76_RS17320	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9K76_RS17325	COG0625	glutathione transferase activity
H9K76_RS17330	COG0762	integral membrane protein
H9K76_RS17350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H9K76_RS17360	COG1215	transferase activity, transferring glycosyl groups
H9K76_RS17380	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H9K76_RS17385	COG5001	Diguanylate cyclase
H9K76_RS17395	COG0205	6-phosphofructokinase activity
H9K76_RS17400	COG4178	(ABC) transporter
H9K76_RS17415	COG0583	DNA-binding transcription factor activity
H9K76_RS17420	COG1472	Belongs to the glycosyl hydrolase 3 family
H9K76_RS17425	COG0736	holo-[acyl-carrier-protein] synthase activity
H9K76_RS17430	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H9K76_RS17435	COG1381	Involved in DNA repair and RecF pathway recombination
H9K76_RS17440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9K76_RS17445	COG0571	ribonuclease III activity
H9K76_RS17455	COG0681	Belongs to the peptidase S26 family
H9K76_RS17460	COG0481	GTPase activity
H9K76_RS17465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9K76_RS17490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9K76_RS17495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9K76_RS17500	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS17510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9K76_RS17515	COG0416	fatty acid biosynthetic process
H9K76_RS17520	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H9K76_RS17525	COG1399	metal-binding, possibly nucleic acid-binding protein
H9K76_RS17530	COG0424	maF-like protein
H9K76_RS17535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H9K76_RS17540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9K76_RS17540	COG0616	signal peptide processing
H9K76_RS17565	COG1530	ribonuclease E activity
H9K76_RS17570	COG3022	response to hydroperoxide
H9K76_RS17580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9K76_RS17580	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9K76_RS17590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9K76_RS17605	COG1304	FMN binding
H9K76_RS17615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9K76_RS17635	COG1802	Transcriptional regulator
H9K76_RS17650	COG0165	Argininosuccinate lyase
H9K76_RS17655	COG3275	phosphorelay sensor kinase activity
H9K76_RS17660	COG3279	Response regulator of the LytR AlgR family
H9K76_RS17665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K76_RS17670	COG0765	amino acid transport
H9K76_RS17675	COG0765	amino acid transport
H9K76_RS17685	COG0412	Dienelactone hydrolase
H9K76_RS17700	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS17710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9K76_RS17710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9K76_RS17720	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H9K76_RS17730	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS17735	COG0697	spore germination
H9K76_RS17750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9K76_RS17755	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H9K76_RS17765	COG0084	hydrolase, TatD family'
H9K76_RS17770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9K76_RS17775	COG0714	Associated with various cellular activities
H9K76_RS17785	COG2304	oxidoreductase activity
H9K76_RS17790	COG1136	(ABC) transporter
H9K76_RS17795	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9K76_RS17805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H9K76_RS17810	COG0613	PHP domain protein
H9K76_RS17815	COG0009	L-threonylcarbamoyladenylate synthase
H9K76_RS17820	COG1994	Peptidase M50
H9K76_RS17825	COG0180	Tryptophanyl-tRNA synthetase
H9K76_RS17830	COG0745	RESPONSE REGULATOR receiver
H9K76_RS17840	COG5002	protein histidine kinase activity
H9K76_RS17850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K76_RS17860	COG1113	amino acid transport
H9K76_RS17870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K76_RS17875	COG4521	taurine ABC transporter
H9K76_RS17880	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H9K76_RS17885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9K76_RS17910	COG1414	Transcriptional regulator
H9K76_RS17935	COG0402	S-adenosylhomocysteine deaminase activity
H9K76_RS17955	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H9K76_RS18005	COG1113	amino acid transport
H9K76_RS18015	COG2388	GCN5-related N-acetyl-transferase
H9K76_RS18040	COG2723	6-phospho-beta-galactosidase activity
H9K76_RS18045	COG0798	PFAM Bile acid sodium symporter
H9K76_RS18085	COG0583	DNA-binding transcription factor activity
H9K76_RS18095	COG1573	uracil-dna glycosylase
H9K76_RS18105	COG2175	clavaminate synthase activity
H9K76_RS18110	COG4521	taurine ABC transporter
H9K76_RS18115	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H9K76_RS18120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9K76_RS18145	COG0252	asparaginase activity
H9K76_RS18150	COG1301	dicarboxylic acid transport
H9K76_RS18175	COG0306	phosphate transporter
H9K76_RS18185	COG1234	tRNA 3'-trailer cleavage
H9K76_RS18195	COG0405	Gamma-glutamyltransferase
H9K76_RS18210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9K76_RS18215	COG0477	Major facilitator Superfamily
H9K76_RS18225	COG4771	TonB-dependent receptor
H9K76_RS18235	COG3128	pkhd-type hydroxylase
H9K76_RS18240	COG4774	siderophore transport
H9K76_RS18260	COG5002	protein histidine kinase activity
H9K76_RS18275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9K76_RS18280	COG1253	flavin adenine dinucleotide binding
H9K76_RS18285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H9K76_RS18295	COG2003	Belongs to the UPF0758 family
H9K76_RS18300	COG1193	negative regulation of DNA recombination
H9K76_RS18305	COG0737	Belongs to the 5'-nucleotidase family
H9K76_RS18320	COG0583	DNA-binding transcription factor activity
H9K76_RS18335	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H9K76_RS18340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H9K76_RS18350	COG0437	4 iron, 4 sulfur cluster binding
H9K76_RS18355	COG2864	formate dehydrogenase
H9K76_RS18370	COG3276	selenocysteine insertion sequence binding
H9K76_RS18505	COG1113	amino acid transport
H9K76_RS18510	COG1309	transcriptional regulator
H9K76_RS18515	COG0493	'glutamate synthase
H9K76_RS18525	COG1953	Uracil, thiamine, allantoin
H9K76_RS18550	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H9K76_RS18555	COG0385	Bile acid
H9K76_RS18575	COG0489	protein tyrosine kinase activity
H9K76_RS18590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K76_RS18590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K76_RS18625	COG1349	DNA-binding transcription factor activity
H9K76_RS18665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H9K76_RS18670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H9K76_RS18675	COG0583	DNA-binding transcription factor activity
H9K76_RS18685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9K76_RS18690	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H9K76_RS18700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K76_RS18705	COG0588	phosphoglycerate mutase activity
H9K76_RS18710	COG0793	Belongs to the peptidase S41A family
H9K76_RS18715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9K76_RS18725	COG2197	response regulator
H9K76_RS18730	COG4585	Histidine kinase
H9K76_RS18735	COG5487	UPF0391 membrane protein
H9K76_RS18755	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H9K76_RS18770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9K76_RS18785	COG0742	ribosomal rna small subunit methyltransferase
H9K76_RS18790	COG0612	Peptidase, M16
H9K76_RS18795	COG0612	Peptidase, M16
H9K76_RS18815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9K76_RS18830	COG0667	Aldo Keto reductase
H9K76_RS18835	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS18840	COG1129	ABC transporter
H9K76_RS18855	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H9K76_RS18860	COG2188	Transcriptional regulator
H9K76_RS18875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9K76_RS18880	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS18885	COG1999	signal sequence binding
H9K76_RS18890	COG0109	protoheme IX farnesyltransferase activity
H9K76_RS18930	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H9K76_RS18945	COG2226	methyltransferase
H9K76_RS18950	COG1040	competence protein
H9K76_RS18955	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H9K76_RS18970	COG1192	Involved in chromosome partitioning
H9K76_RS18975	COG1280	lysine exporter protein (LysE YggA)
H9K76_RS18985	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS18990	COG4829	muconolactone delta-isomerase
H9K76_RS18995	COG2031	fatty acid transporter
H9K76_RS19015	COG0596	Alpha beta hydrolase
H9K76_RS19020	COG0183	Belongs to the thiolase family
H9K76_RS19025	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H9K76_RS19035	COG1414	Transcriptional regulator
H9K76_RS19055	COG0657	acetylesterase activity
H9K76_RS19085	COG2351	hydroxyisourate hydrolase activity
H9K76_RS19090	COG0590	tRNA wobble adenosine to inosine editing
H9K76_RS19110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9K76_RS19125	COG0729	surface antigen
H9K76_RS19180	COG0642	Histidine kinase
H9K76_RS19190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9K76_RS19220	COG0540	Belongs to the ATCase OTCase family
H9K76_RS19225	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H9K76_RS19230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9K76_RS19235	COG1678	Uncharacterized ACR, COG1678
H9K76_RS19240	COG2198	Histidine kinase
H9K76_RS19240	COG0784	Response regulator, receiver
H9K76_RS19240	COG0643	Histidine kinase
H9K76_RS19245	COG0840	transmembrane signaling receptor activity
H9K76_RS19265	COG1773	rubredoxin
H9K76_RS19275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9K76_RS19290	COG0138	bifunctional purine biosynthesis protein purh
H9K76_RS19295	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H9K76_RS19305	COG1238	metal cluster binding
H9K76_RS19315	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS19330	COG4771	TonB-dependent receptor
H9K76_RS19340	COG0012	GTP binding
H9K76_RS19345	COG0583	DNA-binding transcription factor activity
H9K76_RS19360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9K76_RS19375	COG1024	Enoyl-CoA hydratase
H9K76_RS19400	COG0625	glutathione transferase activity
H9K76_RS19410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H9K76_RS19425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9K76_RS19430	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H9K76_RS19435	COG1737	Transcriptional regulator
H9K76_RS19455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K76_RS19460	COG0601	transmembrane transport
H9K76_RS19465	COG0747	negative chemotaxis
H9K76_RS19475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K76_RS19485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9K76_RS19490	COG4137	Cytochrome C assembly protein
H9K76_RS19515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9K76_RS19515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9K76_RS19520	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9K76_RS19530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K76_RS19545	COG2264	protein methyltransferase activity
H9K76_RS19550	COG0439	Biotin carboxylase
H9K76_RS19555	COG0511	ligase activity, forming carbon-carbon bonds
H9K76_RS19560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9K76_RS19570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9K76_RS19580	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9K76_RS19585	COG0312	modulator of DNA gyrase
H9K76_RS19590	COG0772	Belongs to the SEDS family
H9K76_RS19595	COG3150	esterase
H9K76_RS19615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9K76_RS19620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9K76_RS19625	COG1414	Transcriptional regulator
H9K76_RS19630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H9K76_RS19640	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H9K76_RS19650	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H9K76_RS19665	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H9K76_RS19670	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9K76_RS19675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9K76_RS19680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9K76_RS19685	COG0772	Belongs to the SEDS family
H9K76_RS19690	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9K76_RS19695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9K76_RS19700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9K76_RS19705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9K76_RS19720	COG0275	rRNA processing
H9K76_RS19725	COG2001	Belongs to the MraZ family
H9K76_RS19730	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H9K76_RS19735	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H9K76_RS19750	COG0523	cobalamin synthesis protein
H9K76_RS19760	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H9K76_RS19770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H9K76_RS19775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9K76_RS19815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9K76_RS19820	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H9K76_RS19825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H9K76_RS19835	COG0667	Aldo Keto reductase
H9K76_RS19840	COG0501	Belongs to the peptidase M48B family
H9K76_RS19850	COG0418	dihydroorotase activity
H9K76_RS19860	COG0765	amino acid transport
H9K76_RS19865	COG0765	amino acid transport
H9K76_RS19870	COG1126	abc transporter atp-binding protein
H9K76_RS19880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K76_RS19890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9K76_RS19895	COG0683	leucine binding
H9K76_RS19935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9K76_RS19955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9K76_RS19960	COG0025	NhaP-type Na H and K H
H9K76_RS19970	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS19980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9K76_RS19990	COG5002	protein histidine kinase activity
H9K76_RS19990	COG2198	Histidine kinase
H9K76_RS19990	COG0784	Response regulator, receiver
H9K76_RS19995	COG3012	SEC-C Motif Domain Protein
H9K76_RS20000	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS20020	COG0183	Belongs to the thiolase family
H9K76_RS20025	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H9K76_RS20030	COG0288	reversible hydration of carbon dioxide
H9K76_RS20035	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS20040	COG0789	Transcriptional regulator
H9K76_RS20075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H9K76_RS20080	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H9K76_RS20090	COG0850	regulation of cytokinetic process
H9K76_RS20100	COG1183	phosphatidylcholine synthase activity
H9K76_RS20110	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS20115	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS20130	COG0583	DNA-binding transcription factor activity
H9K76_RS20165	COG2233	PERMEase
H9K76_RS20180	COG2050	protein possibly involved in aromatic compounds catabolism
H9K76_RS20190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K76_RS20200	COG2096	Adenosyltransferase
H9K76_RS20210	COG0277	FAD linked oxidase domain protein
H9K76_RS20260	COG5507	3-demethylubiquinone-9 3-methyltransferase
H9K76_RS20270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H9K76_RS20285	COG1475	DNA binding
H9K76_RS20295	COG1192	Involved in chromosome partitioning
H9K76_RS20305	COG0357	Ribosomal RNA small subunit methyltransferase G
H9K76_RS20310	COG0445	tRNA wobble uridine modification
H9K76_RS20320	COG0625	glutathione transferase activity
H9K76_RS20325	COG1902	pentaerythritol trinitrate reductase activity
H9K76_RS20355	COG1797	cobyrinic acid a,c-diamide synthase activity
H9K76_RS20360	COG2217	Heavy metal translocating P-type atpase
H9K76_RS20370	COG0789	Transcriptional regulator
H9K76_RS20380	COG2715	membrane protein required for spore maturation
H9K76_RS20390	COG0583	DNA-binding transcription factor activity
H9K76_RS20400	COG4191	Histidine kinase
H9K76_RS20405	COG1301	dicarboxylic acid transport
H9K76_RS20410	COG2974	May be involved in recombination
H9K76_RS20420	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H9K76_RS20440	COG1024	Enoyl-CoA hydratase
H9K76_RS20455	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS20460	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS20465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9K76_RS20470	COG0791	NLP P60 protein
H9K76_RS20475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9K76_RS20485	COG2176	DNA-directed DNA polymerase activity
H9K76_RS20490	COG1199	ATP-dependent helicase activity
H9K76_RS20505	COG3707	response regulator
H9K76_RS20510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9K76_RS20520	COG1116	anion transmembrane transporter activity
H9K76_RS20525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9K76_RS20530	COG2146	nitrite reductase [NAD(P)H] activity
H9K76_RS20535	COG0243	molybdopterin cofactor binding
H9K76_RS20545	COG1764	response to oxidative stress
H9K76_RS20565	COG0745	RESPONSE REGULATOR receiver
H9K76_RS20570	COG0642	Histidine kinase
H9K76_RS20585	COG0829	nickel cation binding
H9K76_RS20605	COG0559	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS20615	COG0831	urea catabolic process
H9K76_RS20625	COG0832	Belongs to the urease beta subunit family
H9K76_RS20630	COG0804	urea catabolic process
H9K76_RS20645	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H9K76_RS20650	COG0830	nickel cation binding
H9K76_RS20655	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H9K76_RS20660	COG1414	Transcriptional regulator
H9K76_RS20665	COG1024	Enoyl-CoA hydratase
H9K76_RS20690	COG0028	Belongs to the TPP enzyme family
H9K76_RS20695	COG0583	DNA-binding transcription factor activity
H9K76_RS20705	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS20730	COG1690	Belongs to the RtcB family
H9K76_RS20740	COG4650	regulator
H9K76_RS20750	COG0765	amino acid transport
H9K76_RS20755	COG0765	amino acid transport
H9K76_RS20765	COG2814	Major facilitator Superfamily
H9K76_RS20770	COG0583	DNA-binding transcription factor activity
H9K76_RS20775	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS20785	COG0789	Transcriptional regulator
H9K76_RS20835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9K76_RS20840	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H9K76_RS20845	COG0594	ribonuclease P activity
H9K76_RS20850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H9K76_RS20855	COG0706	membrane insertase activity
H9K76_RS20900	COG1446	asparaginase
H9K76_RS20905	COG4172	Belongs to the ABC transporter superfamily
H9K76_RS20920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K76_RS20940	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9K76_RS20955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9K76_RS20980	COG0300	oxidoreductase activity
H9K76_RS20985	COG0724	RNA recognition motif
H9K76_RS20990	COG0724	RNA recognition motif
H9K76_RS20995	COG2119	membrane
H9K76_RS21000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H9K76_RS21005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9K76_RS21015	COG2267	carboxylic ester hydrolase activity
H9K76_RS21030	COG1196	nuclear chromosome segregation
H9K76_RS21045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9K76_RS21060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9K76_RS21065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9K76_RS21105	COG0402	S-adenosylhomocysteine deaminase activity
H9K76_RS21110	COG1079	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS21115	COG4603	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS21120	COG3845	ABC transporter
H9K76_RS21125	COG1744	ABC transporter substrate-binding protein PnrA-like
H9K76_RS21135	COG0410	ABC transporter
H9K76_RS21150	COG0559	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS21160	COG1802	Transcriptional regulator
H9K76_RS21165	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS21185	COG1305	Transglutaminase-like
H9K76_RS21190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9K76_RS21215	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H9K76_RS21230	COG0307	riboflavin synthase, alpha
H9K76_RS21240	COG0494	nUDIX hydrolase
H9K76_RS21265	COG0583	DNA-binding transcription factor activity
H9K76_RS21285	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K76_RS21290	COG0482	sulfurtransferase activity
H9K76_RS21295	COG1620	l-lactate permease
H9K76_RS21300	COG1414	Transcriptional regulator
H9K76_RS21335	COG2084	Dehydrogenase
H9K76_RS21340	COG3622	Belongs to the hyi family
H9K76_RS21345	COG3960	tartronate-semialdehyde synthase activity
H9K76_RS21350	COG0583	DNA-binding transcription factor activity
H9K76_RS21365	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS21385	COG2814	Major facilitator Superfamily
H9K76_RS21390	COG2194	sulfuric ester hydrolase activity
H9K76_RS21420	COG0583	DNA-binding transcription factor activity
H9K76_RS21425	COG0284	orotidine-5'-phosphate decarboxylase activity
H9K76_RS21445	COG0126	phosphoglycerate kinase activity
H9K76_RS21460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9K76_RS21470	COG0242	peptide deformylase activity
H9K76_RS21475	COG1652	LysM domain
H9K76_RS21480	COG0758	DNA mediated transformation
H9K76_RS21485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H9K76_RS21490	COG0045	succinate-CoA ligase (ADP-forming) activity
H9K76_RS21495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H9K76_RS21500	COG0861	Integral membrane protein TerC family
H9K76_RS21510	COG1716	ATPase activity
H9K76_RS21530	COG2814	Major facilitator Superfamily
H9K76_RS21535	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H9K76_RS21540	COG0315	cyclic pyranopterin monophosphate synthase activity
H9K76_RS21545	COG4783	chaperone-mediated protein folding
H9K76_RS21550	COG1950	PFAM Membrane protein of
H9K76_RS21560	COG0861	Integral membrane protein TerC family
H9K76_RS21585	COG0625	glutathione transferase activity
H9K76_RS21600	COG1538	Outer membrane efflux protein
H9K76_RS21605	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H9K76_RS21625	COG4566	intracellular signal transduction
H9K76_RS21640	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H9K76_RS21650	COG1522	sequence-specific DNA binding
H9K76_RS21660	COG1862	Preprotein translocase
H9K76_RS21665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K76_RS21670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K76_RS21690	COG2137	regulation of response to DNA damage stimulus
H9K76_RS21695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9K76_RS21715	COG1012	belongs to the aldehyde dehydrogenase family
H9K76_RS21735	COG0642	Histidine kinase
H9K76_RS21785	COG1566	PFAM secretion protein HlyD family protein
H9K76_RS21875	COG0300	oxidoreductase activity
H9K76_RS21900	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS21920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H9K76_RS21945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9K76_RS21950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H9K76_RS21955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H9K76_RS21965	COG0006	proline dipeptidase activity
H9K76_RS21970	COG1690	Belongs to the RtcB family
H9K76_RS21975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H9K76_RS21980	COG0469	pyruvate kinase activity
H9K76_RS21985	COG0671	phosphoesterase, PA-phosphatase related
H9K76_RS22000	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS22010	COG0598	Magnesium transport protein CorA
H9K76_RS22025	COG1214	PFAM Peptidase M22, glycoprotease
H9K76_RS22040	COG3047	cAMP biosynthetic process
H9K76_RS22050	COG0009	L-threonylcarbamoyladenylate synthase
H9K76_RS22055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H9K76_RS22060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H9K76_RS22065	COG3118	belongs to the thioredoxin family
H9K76_RS22075	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9K76_RS22085	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H9K76_RS22090	COG0735	belongs to the Fur family
H9K76_RS22095	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9K76_RS22100	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9K76_RS22125	COG0668	transmembrane transport
H9K76_RS22130	COG0495	leucyl-tRNA aminoacylation
H9K76_RS22145	COG0662	Cupin 2, conserved barrel domain protein
H9K76_RS22150	COG3639	organic phosphonate transmembrane transporter activity
H9K76_RS22155	COG3639	organic phosphonate transmembrane transporter activity
H9K76_RS22160	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H9K76_RS22185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H9K76_RS22190	COG0569	domain protein
H9K76_RS22195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9K76_RS22205	COG3158	transport of potassium into the cell
H9K76_RS22210	COG3135	benzoate transporter
H9K76_RS22215	COG0189	ligase activity
H9K76_RS22265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9K76_RS22285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9K76_RS22290	COG0081	regulation of translation
H9K76_RS22295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9K76_RS22300	COG0222	ribosome binding
H9K76_RS22305	COG0085	RNA polymerase activity
H9K76_RS22310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9K76_RS22320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9K76_RS22320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9K76_RS22330	COG5000	phosphorelay sensor kinase activity
H9K76_RS22335	COG2204	response regulator
H9K76_RS22385	COG2957	Belongs to the agmatine deiminase family
H9K76_RS22400	COG0583	DNA-binding transcription factor activity
H9K76_RS22420	COG0745	RESPONSE REGULATOR receiver
H9K76_RS22440	COG4771	TonB-dependent receptor
H9K76_RS22445	COG0656	L-ascorbic acid biosynthetic process
H9K76_RS22455	COG2365	Tyrosine phosphatase family
H9K76_RS22490	COG0204	Acyl-transferase
H9K76_RS22490	COG0318	PFAM AMP-dependent synthetase and ligase
H9K76_RS22510	COG3706	GGDEF domain
H9K76_RS22515	COG0343	queuine tRNA-ribosyltransferase activity
H9K76_RS22540	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS22545	COG1024	Enoyl-CoA hydratase
H9K76_RS22550	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS22580	COG0210	DNA helicase
H9K76_RS22605	COG0679	Auxin Efflux Carrier
H9K76_RS22620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H9K76_RS22625	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H9K76_RS22640	COG1832	CoA-binding protein
H9K76_RS22650	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9K76_RS22670	COG0534	Mate efflux family protein
H9K76_RS22715	COG0384	phenazine biosynthesis protein PhzF
H9K76_RS22725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K76_RS22735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K76_RS22745	COG2201	protein-glutamate methylesterase activity
H9K76_RS22750	COG2198	Histidine kinase
H9K76_RS22750	COG0643	Histidine kinase
H9K76_RS22755	COG0835	chemotaxis
H9K76_RS22760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H9K76_RS22765	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H9K76_RS22770	COG2201	protein-glutamate methylesterase activity
H9K76_RS22775	COG0488	(ABC) transporter
H9K76_RS22805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K76_RS22810	COG0583	DNA-binding transcription factor activity
H9K76_RS22845	COG2186	Transcriptional regulator
H9K76_RS22850	COG0778	Nitroreductase
H9K76_RS22865	COG0346	lactoylglutathione lyase activity
H9K76_RS22870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9K76_RS22885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9K76_RS22900	COG4120	Belongs to the binding-protein-dependent transport system permease family
H9K76_RS22915	COG1802	Transcriptional regulator
H9K76_RS22920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H9K76_RS22930	COG2814	Major facilitator Superfamily
H9K76_RS22960	COG1917	Cupin 2, conserved barrel domain protein
H9K76_RS22990	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H9K76_RS23005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H9K76_RS23010	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS23015	COG2205	protein histidine kinase activity
H9K76_RS23020	COG0745	RESPONSE REGULATOR receiver
H9K76_RS23035	COG1136	(ABC) transporter
H9K76_RS23035	COG0577	efflux transmembrane transporter activity
H9K76_RS23055	COG2076	Multidrug Resistance protein
H9K76_RS23070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9K76_RS23105	COG3181	Tripartite tricarboxylate transporter family receptor
H9K76_RS23115	COG1028	Short-chain dehydrogenase reductase Sdr
H9K76_RS23120	COG0583	DNA-binding transcription factor activity
H9K76_RS23150	COG1760	l-serine dehydratase
H9K76_RS23155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9K76_RS23155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9K76_RS23180	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
H9K76_RS23185	COG1960	acyl-CoA dehydrogenase activity
H9K76_RS23205	COG2301	Belongs to the HpcH HpaI aldolase family
H9K76_RS23215	COG0477	Major facilitator Superfamily
H9K76_RS23220	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H9K76_RS23225	COG1414	Transcriptional regulator
H9K76_RS23240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H9K76_RS23245	COG2326	polyphosphate kinase activity
H9K76_RS23260	COG0402	S-adenosylhomocysteine deaminase activity
H9K76_RS23265	COG0583	DNA-binding transcription factor activity
H9K76_RS23275	COG0583	DNA-binding transcription factor activity