locus-tag class description G7048_RS00005 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS00015 ENOG4105C0Z ABC transporter G7048_RS00020 ENOG4108IV0 ABC, transporter G7048_RS00045 ENOG4105M4H endoribonuclease L-psp G7048_RS00065 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) G7048_RS00070 ENOG4108IJ6 ABC transporter G7048_RS00075 ENOG4105ECW sulfate abc transporter G7048_RS00080 ENOG4108I5D sulfate abc transporter G7048_RS00085 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G7048_RS00095 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G7048_RS00100 ENOG4105C1J atp-dependent rna helicase G7048_RS00105 ENOG41067MG lrgb family G7048_RS00115 ENOG4108JJB ABC transporter G7048_RS00125 ENOG4107ZYJ bioY protein G7048_RS00130 ENOG4107F3J Amp-dependent synthetase and ligase G7048_RS00150 ENOG4105D01 (LipO)protein G7048_RS00170 ENOG4108UMI ABC transporter, permease G7048_RS00175 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G7048_RS00195 ENOG4107R11 Transcriptional regulator G7048_RS00215 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G7048_RS00220 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) G7048_RS00225 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) G7048_RS00250 ENOG4105C11 sulfate adenylyltransferase), subunit 2 G7048_RS00260 ENOG4108Z4U Ferredoxin G7048_RS00265 ENOG4105CAY ferredoxin--nadp reductase G7048_RS00305 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) G7048_RS00315 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G7048_RS00320 ENOG4108UKI Enoyl-CoA hydratase G7048_RS00335 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS00350 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G7048_RS00360 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC G7048_RS00375 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region G7048_RS00380 ENOG41061WM D-Alanyl-D-Alanine G7048_RS00385 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G7048_RS00390 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase G7048_RS00395 ENOG4108ZP8 Acetolactate synthase small subunit G7048_RS00400 ENOG4105C7K acetolactate synthase G7048_RS00425 ENOG41080IJ Diacylglycerol kinase G7048_RS00430 ENOG4108URH decarboxylase G7048_RS00435 ENOG4108YZA Nitrogen regulatory protein pii G7048_RS00450 ENOG4108V3W Chemotaxis protein, CheW G7048_RS00455 ENOG4105F0N pyrophosphate phospho-hydrolase G7048_RS00475 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G7048_RS00485 ENOG4105CVM Molybdenum cofactor synthesis domain protein G7048_RS00495 ENOG41063ZV G7048_RS00500 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G7048_RS00505 ENOG4107QNM Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) G7048_RS00510 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G7048_RS00515 ENOG4105E9H Lytic Murein transglycosylase G7048_RS00520 ENOG4105D2X ABC transporter substrate-binding protein G7048_RS00530 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G7048_RS00535 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G7048_RS00540 ENOG4107QMP dna polymerase iii subunits gamma and tau G7048_RS00585 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G7048_RS00590 ENOG4105D0S secretion protein (HlyD G7048_RS00595 ENOG4105CJ1 ABC, transporter G7048_RS00600 ENOG4105CMI transporter G7048_RS00605 ENOG4105NRA 50s ribosomal protein l31 type b G7048_RS00615 ENOG4107QI1 Mate efflux family protein G7048_RS00620 ENOG4105BZU Histidine kinase G7048_RS00625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G7048_RS00630 ENOG4108UTW Plays a role in the regulation of phosphate uptake G7048_RS00635 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G7048_RS00640 ENOG4105E2Z phosphate ABC transporter (Permease G7048_RS00645 ENOG4105C8U phosphate abc transporter G7048_RS00650 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) G7048_RS00660 ENOG4105C9X ppx gppa phosphatase G7048_RS00675 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) G7048_RS00685 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G7048_RS00690 ENOG4105EEI dihydropteroate synthase G7048_RS00695 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G7048_RS00700 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) G7048_RS00705 ENOG4105HBR Rna-binding protein G7048_RS00720 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G7048_RS00725 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G7048_RS00730 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G7048_RS00735 ENOG4105FFC UPF0187 protein G7048_RS00780 ENOG4105CFH Aspartokinase G7048_RS00785 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G7048_RS00790 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) G7048_RS00800 ENOG4105C8N cysteinyl-tRNA synthetase G7048_RS00845 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G7048_RS00850 ENOG4108YXU transcriptional regulator AsnC family G7048_RS00860 ENOG4105CC0 LysR family Transcriptional regulator G7048_RS00865 ENOG4105C2I pirin domain protein G7048_RS00880 ENOG4105EFZ amidohydrolase G7048_RS00895 ENOG4108YZN class I peptide chain release factor G7048_RS00905 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G7048_RS00920 ENOG4105EW9 transcriptional regulator AsnC family G7048_RS00925 ENOG4105C26 Dehydrogenase G7048_RS00930 ENOG4107ZT5 Thiol disulfide interchange protein G7048_RS00965 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G7048_RS00990 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G7048_RS01025 ENOG4105BZU Histidine kinase G7048_RS01045 ENOG4105F8V Hydrolase, tatD family G7048_RS01050 ENOG4105W5Q DNA repair protein (RadC G7048_RS01075 ENOG4105FEQ ParB domain protein nuclease G7048_RS01180 ENOG4106517 Short-chain dehydrogenase reductase Sdr G7048_RS01190 ENOG4105CHR reductase G7048_RS01195 ENOG4105CSH Transporter G7048_RS01205 ENOG4107RSM transcriptional regulator G7048_RS01215 ENOG4105CNA YD repeat protein G7048_RS01220 ENOG4105ID8 Transcriptional regulator, ARAC family G7048_RS01235 ENOG4106NZI LysR family Transcriptional regulator G7048_RS01255 ENOG4105DKK Benzoate G7048_RS01260 ENOG4105DFA alanine racemase domain protein G7048_RS01270 ENOG4105C8Y Acetylornithine aminotransferase G7048_RS01275 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) G7048_RS01280 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G7048_RS01285 ENOG4106NZI LysR family Transcriptional regulator G7048_RS01385 ENOG4105DFP Integrase G7048_RS01390 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G7048_RS01415 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G7048_RS01450 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) G7048_RS01455 ENOG4105C01 Dihydroxy-acid dehydratase G7048_RS01460 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G7048_RS01475 ENOG4108Z1B Cyclase dehydrase G7048_RS01480 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) G7048_RS01490 ENOG4105CGU Enoyl-CoA hydratase G7048_RS01540 ENOG41083Z3 extracellular ligand-binding receptor G7048_RS01560 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein G7048_RS01565 ENOG4105CI3 gtp-binding protein typa G7048_RS01570 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) G7048_RS01575 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) G7048_RS01580 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) G7048_RS01585 ENOG4105CHV Transcription elongation factor NusA G7048_RS01590 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) G7048_RS01600 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding G7048_RS01610 ENOG4105EMU Dehydrogenase G7048_RS01615 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G7048_RS01655 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G7048_RS01665 ENOG4105F1J Homogentisate 1,2-dioxygenase G7048_RS01675 ENOG4105WAP TPR repeat-containing protein G7048_RS01690 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G7048_RS01705 ENOG41090Y2 cytochrome C G7048_RS01725 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G7048_RS01730 ENOG4107RCV ABC transporter, permease G7048_RS01740 ENOG4105CSU acyl-Coa dehydrogenase G7048_RS01760 ENOG4105CHU acetyl-coa acetyltransferase G7048_RS01765 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G7048_RS01770 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G7048_RS01775 ENOG4108IV0 ABC, transporter G7048_RS01780 ENOG4105C0Z ABC transporter G7048_RS01790 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS01795 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS01800 ENOG4105CNG UPF0061 protein G7048_RS01805 ENOG4105E0X reductase G7048_RS01810 ENOG4107835 probably involved in intracellular septation (By similarity) G7048_RS01820 ENOG4107TF3 peptidylprolyl cis-trans isomerase G7048_RS01850 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) G7048_RS01855 ENOG4108IJ8 ABC transporter G7048_RS01860 ENOG4105DJ4 phosphatidylserine decarboxylase G7048_RS01910 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G7048_RS01915 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G7048_RS01920 ENOG4105UYK outer membrane protein a G7048_RS01925 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G7048_RS01930 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G7048_RS01940 ENOG4105EVN Prephenate dehydrogenase G7048_RS01945 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G7048_RS01950 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G7048_RS01955 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) G7048_RS01965 ENOG4105CFV Tetratricopeptide repeat protein G7048_RS01975 ENOG4105D65 subunit l G7048_RS01980 ENOG4108ZE9 Monovalent cation H antiporter subunit C G7048_RS01985 ENOG4107R4Z monovalent cation h antiporter subunit d G7048_RS01995 ENOG4105W4C monovalent cation H antiporter subunit F G7048_RS02000 ENOG4105KJM monovalent cation h antiporter subunit g G7048_RS02010 ENOG4107Z6W Protein CrcB homolog G7048_RS02020 ENOG4105C8Q Methyl-accepting chemotaxis G7048_RS02035 ENOG4105C5I Dehydrogenase G7048_RS02045 ENOG4107RH7 Nicotinate phosphoribosyltransferase G7048_RS02055 ENOG4108WFY phasin family G7048_RS02105 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G7048_RS02110 ENOG4105C28 cystathionine G7048_RS02115 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase G7048_RS02125 ENOG4108S3P Sporulation domain protein G7048_RS02130 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G7048_RS02135 ENOG4105KUZ arsenate reductase G7048_RS02145 ENOG4105NBK UPF0345 protein G7048_RS02150 ENOG4105CDH Citrulline--aspartate ligase G7048_RS02170 ENOG4108VPT UPF0234 protein G7048_RS02175 ENOG4108WIW Aspartyl protease G7048_RS02185 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) G7048_RS02190 ENOG4108Z66 YbaK ebsC protein G7048_RS02195 ENOG4105CPC Aldo Keto reductase G7048_RS02200 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G7048_RS02205 ENOG4108XG2 Histidine kinase G7048_RS02220 ENOG4105CD8 aminopeptidase N G7048_RS02225 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 G7048_RS02235 ENOG4108KU3 Integrase G7048_RS02270 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS02285 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G7048_RS02290 ENOG41063TF transcriptional regulator (AraC G7048_RS02295 ENOG4105C85 amino acid G7048_RS02320 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G7048_RS02325 ENOG4105C2D reductase G7048_RS02335 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G7048_RS02345 ENOG4107T3I fad-binding protein G7048_RS02365 ENOG4105C84 Histidine ammonia-lyase G7048_RS02395 ENOG4107IQ5 Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G7048_RS02400 ENOG4105E9Q Acyl-transferase G7048_RS02450 ENOG4107EFR Flavocytochrome c G7048_RS02465 ENOG4108R85 Short chain dehydrogenase G7048_RS02470 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G7048_RS02475 ENOG4105ETT transcriptional Regulator, LysR family G7048_RS02480 ENOG4105C26 Dehydrogenase G7048_RS02490 ENOG4108JUA Transcriptional regulator G7048_RS02495 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS02500 ENOG4108IPT Naphthoate synthase G7048_RS02505 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS02510 ENOG4105E39 Enoyl-CoA hydratase G7048_RS02515 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G7048_RS02520 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS02525 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G7048_RS02530 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G7048_RS02545 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G7048_RS02555 ENOG4105C0Z ABC transporter G7048_RS02560 ENOG4108IV0 ABC, transporter G7048_RS02565 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS02625 ENOG4108WYP Transcriptional regulator G7048_RS02635 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G7048_RS02640 ENOG4105JSC dimethylmenaquinone methyltransferase G7048_RS02660 ENOG4108W5M transcriptional regulator G7048_RS02670 ENOG4108XDN Transcriptional regulator G7048_RS02675 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) G7048_RS02680 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G7048_RS02685 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) G7048_RS02690 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) G7048_RS02695 ENOG4105VJV 50s ribosomal protein L35 G7048_RS02700 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) G7048_RS02705 ENOG4105C22 threonyL-tRNA synthetase G7048_RS02725 ENOG4108I9X Isocitrate lyase G7048_RS02735 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) G7048_RS02760 ENOG4105SG9 biopolymer transport protein, ExbD G7048_RS02775 ENOG4108ZJF Glcg protein G7048_RS02780 ENOG4108MN8 Membrane G7048_RS02785 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G7048_RS02790 ENOG4105CX6 glutaminyL-tRNA synthetase G7048_RS02795 ENOG4108NST exported protein G7048_RS02810 ENOG4107QX3 carboxylase G7048_RS02815 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS02835 ENOG4107NQ8 LysR family Transcriptional regulator G7048_RS02845 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS02850 ENOG4105DTR rard protein G7048_RS02855 ENOG4105KK6 nuclease G7048_RS02870 ENOG4105ED1 spovr family G7048_RS02875 ENOG4106AKX UPF0229 protein G7048_RS02880 ENOG4105CYN Serine protein kinase G7048_RS02890 ENOG4105DR9 pseudouridine synthase G7048_RS02905 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) G7048_RS02920 ENOG4105C7K acetolactate synthase G7048_RS02930 ENOG4105D78 K07001 NTE family protein G7048_RS02940 ENOG4105D9M gamma-glutamylcysteine synthetase G7048_RS02945 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G7048_RS02955 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G7048_RS02960 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G7048_RS02965 ENOG4107YIM Involved in the transcription termination process (By similarity) G7048_RS02970 ENOG4105CHM Aminotransferase G7048_RS02975 ENOG4107YD3 Thioesterase G7048_RS02980 ENOG4105E02 MotA TolQ exbB proton channel G7048_RS02985 ENOG4105M8F Biopolymer transport protein exbD tolR G7048_RS03005 ENOG4105CSH Transporter G7048_RS03010 ENOG4105E2S oxidase) subunit II G7048_RS03015 ENOG4105BZ9 Cytochrome C oxidase, subunit I G7048_RS03020 ENOG4105CCU oxidase (Subunit III) G7048_RS03025 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) G7048_RS03040 ENOG4108UYB regulatoR G7048_RS03060 ENOG4105CFP Peptidase U32 G7048_RS03070 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS03080 ENOG4105CSU acyl-Coa dehydrogenase G7048_RS03085 ENOG4106NZI LysR family Transcriptional regulator G7048_RS03110 ENOG4105EX9 Membrane G7048_RS03120 ENOG4107QIJ Aconitate hydratase 2 G7048_RS03135 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) G7048_RS03140 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G7048_RS03145 ENOG4105FDP GntR family transcriptional regulator G7048_RS03150 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) G7048_RS03165 ENOG4105E33 succinate dehydrogenase G7048_RS03170 ENOG41060IS Flavinator of succinate dehydrogenase G7048_RS03175 ENOG4105BZN citrate synthase G7048_RS03190 ENOG4105C4W S-formylglutathione hydrolase G7048_RS03215 ENOG410904N short-chain dehydrogenase reductase G7048_RS03230 ENOG4105NXH GreA GreB family elongation factor G7048_RS03240 ENOG4105C09 Bile acid G7048_RS03245 ENOG4105EMY transcriptional regulator G7048_RS03270 ENOG4105CSU acyl-Coa dehydrogenase G7048_RS03275 ENOG4105C10 Electron transfer flavoprotein G7048_RS03280 ENOG4105BZJ Electron transfer flavoprotein G7048_RS03285 ENOG4105EGS Mechanosensitive ion channel G7048_RS03300 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G7048_RS03310 ENOG4105F8C transglutaminase domain-containing protein G7048_RS03315 ENOG4105CVE Lytic murein transglycosylase G7048_RS03320 ENOG4105ES9 amino acid G7048_RS03340 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G7048_RS03345 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G7048_RS03350 ENOG410624X efflux transporter, rnd family, mfp subunit G7048_RS03360 ENOG4105CS1 NAD(P)H quinone oxidoreductase G7048_RS03365 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G7048_RS03370 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G7048_RS03385 ENOG4105PGM cation diffusion facilitator family transporter G7048_RS03390 ENOG4105E3W Two component transcriptional regulator (Winged helix family G7048_RS03395 ENOG4105EB3 Histidine kinase G7048_RS03400 ENOG4105C1P efflux transporter, rnd family, mfp subunit G7048_RS03405 ENOG4105BZS acriflavin resistance protein G7048_RS03410 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G7048_RS03575 ENOG4108TFU terminase (Small subunit) G7048_RS03600 ENOG4106FAK Endodeoxyribonuclease RusA G7048_RS03610 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G7048_RS03615 ENOG4105CDU Replicative dna helicase G7048_RS03660 ENOG4107R08 Integrase G7048_RS03680 ENOG4105CPN adenine deaminase G7048_RS03790 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G7048_RS03930 ENOG4107R08 Integrase G7048_RS03940 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G7048_RS03950 ENOG4105DTD Dehydrogenase G7048_RS03965 ENOG4105E0F Histidine kinase G7048_RS03970 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) G7048_RS03975 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) G7048_RS03980 ENOG4108JA2 transcriptioN-repair coupling factor G7048_RS03995 ENOG4105EAC phosphoserine phosphatase G7048_RS04000 ENOG4105D01 (LipO)protein G7048_RS04015 ENOG4108ZUB Lysine exporter protein (Lyse ygga) G7048_RS04020 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) G7048_RS04030 ENOG4105C4Y ABC transporter G7048_RS04040 ENOG4107RCV ABC transporter, permease G7048_RS04050 ENOG4105C6N Formate acetyltransferase G7048_RS04060 ENOG4105VRT cytoplasmic protein G7048_RS04070 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G7048_RS04075 ENOG41080UQ Transcriptional regulator G7048_RS04080 ENOG4105CPC Aldo Keto reductase G7048_RS04090 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G7048_RS04105 ENOG4105CSM endonuclease III G7048_RS04120 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G7048_RS04125 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G7048_RS04140 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase G7048_RS04145 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) G7048_RS04150 ENOG4105EHG Permease protein G7048_RS04160 ENOG4108YZT Adenosylcobinamide kinase G7048_RS04165 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) G7048_RS04185 ENOG4105D4P Coproporphyrinogen iii oxidase G7048_RS04190 ENOG4105DS0 Transcriptional regulator, Crp Fnr family G7048_RS04205 ENOG4105C58 cytochrome c oxidase accessory protein ccog G7048_RS04225 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i G7048_RS04235 ENOG4105C59 p-type ATPase G7048_RS04250 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS04265 ENOG4105E39 Enoyl-CoA hydratase G7048_RS04285 ENOG4105DRR Transcriptional regulator, GntR family G7048_RS04290 ENOG4108K2P TRANSCRIPTIONal G7048_RS04315 ENOG4106HB6 Alpha beta hydrolase G7048_RS04320 ENOG4105FE1 phytoene synthase G7048_RS04325 ENOG4107S11 squalene-associated FAD-dependent desaturase G7048_RS04330 ENOG4107S2Z UPF0761 membrane protein G7048_RS04340 ENOG4105CQB FAD linked oxidase domain protein G7048_RS04350 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) G7048_RS04360 ENOG4105CGK Exodeoxyribonuclease III G7048_RS04390 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G7048_RS04395 ENOG4106G6Q Transcriptional regulator G7048_RS04400 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G7048_RS04405 ENOG4105CUX Signal transduction histidine kinase G7048_RS04445 ENOG4105I08 Pseudouridine synthase G7048_RS04480 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G7048_RS04485 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) G7048_RS04495 ENOG4105EPW hflc protein G7048_RS04500 ENOG4107QJR hflk protein G7048_RS04505 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G7048_RS04510 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) G7048_RS04515 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G7048_RS04530 ENOG4105CUT histidyl-tRNA synthetase G7048_RS04550 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G7048_RS04555 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G7048_RS04560 ENOG4105FE9 pseudouridine synthase G7048_RS04565 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G7048_RS04570 ENOG4105C34 Pseudouridine synthase G7048_RS04575 ENOG4108K5P (LipO)protein G7048_RS04580 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G7048_RS04585 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) G7048_RS04590 ENOG4105DGI Alkaline phosphatase G7048_RS04595 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase G7048_RS04610 ENOG4108SBK dioxygenase, subunit beta G7048_RS04620 ENOG4108W5M transcriptional regulator G7048_RS04625 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) G7048_RS04645 ENOG4108HRK Histidine kinase G7048_RS04650 ENOG4108VAC response regulator G7048_RS04655 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) G7048_RS04665 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G7048_RS04670 ENOG4105BZS acriflavin resistance protein G7048_RS04675 ENOG4105BZS acriflavin resistance protein G7048_RS04695 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G7048_RS04705 ENOG4105MSY salicylate hydroxylase G7048_RS04710 ENOG4107QM5 aconitate hydratase G7048_RS04715 ENOG4107M1U Histone family protein nucleoid-structuring protein H-NS G7048_RS04720 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) G7048_RS04750 ENOG4105DH4 Periplasmic copper-binding protein G7048_RS04755 ENOG4105CIG ABC transporter G7048_RS04760 ENOG4108T0W nitrous oxide maturation protein NosY G7048_RS04770 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G7048_RS04775 ENOG4105E4C Lytic transglycosylase catalytic G7048_RS04780 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G7048_RS04800 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G7048_RS04805 ENOG4105GJM (LipO)protein G7048_RS04810 ENOG4105Q2H domain protein G7048_RS04825 ENOG4105EZE Cupin 4 family protein G7048_RS04830 ENOG4108YZY peptidylprolyl cis-trans isomerase G7048_RS04840 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) G7048_RS04850 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase G7048_RS04855 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G7048_RS04860 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase G7048_RS04870 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) G7048_RS04875 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) G7048_RS04890 ENOG4108Z0R Transferase G7048_RS04895 ENOG4105ED9 Protein of unknown function (DUF455) G7048_RS04910 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G7048_RS04925 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) G7048_RS04930 ENOG4105K8N protein family UPF0079, ATPase G7048_RS04935 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G7048_RS04945 ENOG4105DQR SNARE associated Golgi G7048_RS04950 ENOG4105DVE abc transporter atp-binding protein G7048_RS04965 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G7048_RS04975 ENOG4105D82 Glutamate dehydrogenase G7048_RS04985 ENOG4108NIW Leucine export protein LeuE G7048_RS04990 ENOG4105EAB amino acid AbC transporter G7048_RS04995 ENOG4105MFV ABC-2 type transporter G7048_RS05045 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G7048_RS05050 ENOG4105C8S subunit m G7048_RS05055 ENOG4105D65 subunit l G7048_RS05060 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G7048_RS05065 ENOG4105DF2 NADH dehydrogenase subunit j G7048_RS05070 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G7048_RS05075 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) G7048_RS05080 ENOG4108IEH NADH dehydrogenase subunit g G7048_RS05085 ENOG4107QIZ NADH dehydrogenase G7048_RS05095 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G7048_RS05100 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G7048_RS05105 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G7048_RS05110 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G7048_RS05120 ENOG4107EJC Preprotein translocase subunit SecG G7048_RS05125 ENOG4105CP7 Triose-phosphate isomerase G7048_RS05135 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G7048_RS05140 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) G7048_RS05150 ENOG4108RRZ Transcription elongation factor GreB G7048_RS05155 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G7048_RS05160 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) G7048_RS05165 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G7048_RS05170 ENOG4105DSJ YicC domain protein G7048_RS05190 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G7048_RS05195 ENOG4105CSA Coproporphyrinogen iii oxidase G7048_RS05225 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) G7048_RS05230 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G7048_RS05235 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G7048_RS05240 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) G7048_RS05245 ENOG4105CEN a g-specific adenine glycosylase G7048_RS05255 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G7048_RS05260 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein G7048_RS05270 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) G7048_RS05280 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G7048_RS05285 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) G7048_RS05290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G7048_RS05295 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding G7048_RS05305 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G7048_RS05315 ENOG4108JQ7 (ABC) transporter G7048_RS05320 ENOG4105DEF Extracellular solute-binding protein, family 5 G7048_RS05325 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G7048_RS05330 ENOG410829K Lysine exporter protein (Lyse ygga) G7048_RS05360 ENOG4105EUJ GTP cyclohydrolase i G7048_RS05365 ENOG4105DZQ phospholipase D Transphosphatidylase G7048_RS05385 ENOG4105C9M aspartyl-trna synthetase G7048_RS05400 ENOG4105CK7 Sodium proline symporter G7048_RS05405 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) G7048_RS05425 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G7048_RS05445 ENOG4105FDT acyl-CoA dehydrogenase G7048_RS05450 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G7048_RS05465 ENOG4108UZX fmn reductase G7048_RS05475 ENOG4108JQ1 Dehydrogenase G7048_RS05505 ENOG4107T6V glycerophosphoryl diester phosphodiesterase G7048_RS05510 ENOG4105EGS Mechanosensitive ion channel G7048_RS05515 ENOG4105Q26 Siderophore-interacting protein G7048_RS05530 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) G7048_RS05535 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) G7048_RS05550 ENOG4105C37 (CBS) domain G7048_RS05555 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division G7048_RS05560 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) G7048_RS05565 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G7048_RS05570 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) G7048_RS05575 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G7048_RS05580 ENOG4105K46 50S ribosomal protein l27 G7048_RS05585 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) G7048_RS05590 ENOG4105EAH synthase G7048_RS05600 ENOG4107QHF type ii secretion system protein e G7048_RS05610 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) G7048_RS05615 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G7048_RS05620 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) G7048_RS05625 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) G7048_RS05630 ENOG4105M6F mutator MutT protein G7048_RS05640 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G7048_RS05645 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G7048_RS05660 ENOG4105KB2 stringent starvation protein b G7048_RS05665 ENOG4107MKT Stringent starvation protein a G7048_RS05670 ENOG4105EIX cytochrome c1 G7048_RS05675 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G7048_RS05680 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G7048_RS05685 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) G7048_RS05690 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G7048_RS05700 ENOG4105CSH Transporter G7048_RS05705 ENOG4105C0H protease G7048_RS05710 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G7048_RS05715 ENOG4107Z6S Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) G7048_RS05720 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G7048_RS05725 ENOG4107YU2 histidine triad (hIT) protein G7048_RS05740 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase G7048_RS05745 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G7048_RS05760 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) G7048_RS05765 ENOG4105DSB aldose 1-epimerase G7048_RS05770 ENOG4105CMR udp-glucose 4-epimerase G7048_RS05780 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G7048_RS05790 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G7048_RS05795 ENOG4105CIH Imidazole acetol-phosphate transaminase G7048_RS05820 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G7048_RS05825 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G7048_RS05835 ENOG4105E3A (ABC) transporter G7048_RS05840 ENOG4105DA5 (ABC) transporter G7048_RS05860 ENOG4107PE3 Mammalian cell entry related domain protein G7048_RS05865 ENOG4105CY3 ABC transporter, permease G7048_RS05870 ENOG4105DHJ ABC, transporter G7048_RS05875 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) G7048_RS05880 ENOG4105CDA abc transporter atp-binding protein G7048_RS05885 ENOG4105E5Q amino acid AbC transporter G7048_RS05890 ENOG4106TNF Periplasmic binding protein G7048_RS05900 ENOG4105C2C drug resistance transporter, Bcr CflA G7048_RS05905 ENOG4105C1J atp-dependent rna helicase G7048_RS05910 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) G7048_RS05915 ENOG4105D0M Protease HtpX homolog G7048_RS05920 ENOG41090A4 Pterin carbinolamine dehydratase G7048_RS05925 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G7048_RS05930 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) G7048_RS05935 ENOG4105P8F nudix hydrolase G7048_RS05940 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) G7048_RS05945 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) G7048_RS05950 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G7048_RS05955 ENOG4105K5M 30s ribosomal protein S16 G7048_RS05970 ENOG4107QXV Phosphate transporter G7048_RS05975 ENOG4107GRR phosphate transport regulator G7048_RS05985 ENOG4108IV0 ABC, transporter G7048_RS05990 ENOG4105C0Z ABC transporter G7048_RS05995 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G7048_RS06000 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS06210 ENOG4105D1H recombination factor protein RarA G7048_RS06215 ENOG4105D1H recombination factor protein RarA G7048_RS06220 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) G7048_RS06225 ENOG4105CNU cell division protein FtsK G7048_RS06230 ENOG4105C3M thioredoxin reductase G7048_RS06235 ENOG4105KDC 50s ribosomal protein l28 G7048_RS06240 ENOG4105W0E 50S ribosomal protein L33 G7048_RS06245 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G7048_RS06270 ENOG4108V3E phosphoribosylglycinamide formyltransferase G7048_RS06275 ENOG4108YXG UPF0502 protein G7048_RS06280 ENOG4105X7H acyl-CoA dehydrogenase G7048_RS06285 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS06290 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G7048_RS06295 ENOG4108UMI ABC transporter, permease G7048_RS06300 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G7048_RS06305 ENOG4105D01 (LipO)protein G7048_RS06315 ENOG4105E2Y ABC, transporter G7048_RS06345 ENOG4108IV0 ABC, transporter G7048_RS06350 ENOG4105C0Z ABC transporter G7048_RS06360 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS06375 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G7048_RS06395 ENOG4105C9B Cysteine desulfurase G7048_RS06400 ENOG4105ESN nucleotide-binding protein G7048_RS06410 ENOG4105D7W serine acetyltransferase G7048_RS06430 ENOG4105DTN riboflavin biosynthesis protein ribF G7048_RS06435 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) G7048_RS06440 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) G7048_RS06470 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G7048_RS06490 ENOG4108Z9W Outer membrane porin G7048_RS06505 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G7048_RS06515 ENOG4105EAM Na Pi-cotransporter G7048_RS06520 ENOG4105DHU Bile acid G7048_RS06525 ENOG4108M0I Transcriptional regulator G7048_RS06535 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G7048_RS06570 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 G7048_RS06615 ENOG4105C4R Atp-dependent dna helicase G7048_RS06620 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) G7048_RS06635 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G7048_RS06675 ENOG4105G6Z alkaline phosphatase G7048_RS06690 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein G7048_RS06705 ENOG4105E4G Type IV pilus G7048_RS06730 ENOG4108JQC penicillin-binding protein 1A G7048_RS06735 ENOG4105XQ6 frataxin-like protein G7048_RS06750 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) G7048_RS06755 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G7048_RS06760 ENOG4105CRE cytochrome C G7048_RS06765 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) G7048_RS06770 ENOG4106RE7 Cytochrome G7048_RS06775 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) G7048_RS06780 ENOG4105D1S lipid A biosynthesis G7048_RS06790 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G7048_RS06810 ENOG4107RH7 Nicotinate phosphoribosyltransferase G7048_RS06835 ENOG4105CPK Glycosyl transferase (Group 1 G7048_RS06840 ENOG4108TJN glycosyl transferase group 1 G7048_RS06845 ENOG4108DMA Nad-dependent epimerase dehydratase G7048_RS06850 ENOG4105C0K Gdp-mannose 4,6-dehydratase G7048_RS06865 ENOG4105CKK Glycosyl transferase, family 2 G7048_RS06890 ENOG4105EY8 ABC transporter G7048_RS06910 ENOG4105EYH Exonuclease G7048_RS06915 ENOG4107RH8 nuclease SbcCD subunit D G7048_RS06920 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) G7048_RS06925 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) G7048_RS06930 ENOG4107RP9 extracellular solute-binding protein, family 3 G7048_RS06935 ENOG4107QP8 phosphohexose isomerase G7048_RS06940 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G7048_RS06945 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G7048_RS06965 ENOG4108JQ7 (ABC) transporter G7048_RS06970 ENOG4105C3U ABC transporter G7048_RS06975 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G7048_RS06980 ENOG4105CH2 amidohydrolase G7048_RS06990 ENOG4108Z9W Outer membrane porin G7048_RS06995 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) G7048_RS07000 ENOG4108UKZ OsmC family G7048_RS07005 ENOG4105C7B Threonine dehydratase G7048_RS07010 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) G7048_RS07025 ENOG4108VAU general secretion pathway protein G G7048_RS07035 ENOG4105X5Z General secretion pathway protein I G7048_RS07040 ENOG4108WWZ General secretion pathway protein J G7048_RS07065 ENOG4105GVR general secretion pathway protein D G7048_RS07070 ENOG4107QHF type ii secretion system protein e G7048_RS07080 ENOG4105DEN Luciferase family G7048_RS07085 ENOG4105D7Q type ii secretion system G7048_RS07100 ENOG4105BZ1 (ABC) transporter G7048_RS07115 ENOG4108RH0 Crea protein G7048_RS07125 ENOG4105F1J Homogentisate 1,2-dioxygenase G7048_RS07145 ENOG4105DG4 malate L-lactate dehydrogenase G7048_RS07160 ENOG4108R6W Transcriptional regulator, ARAC family G7048_RS07165 ENOG4108Z33 Thiol disulfide Interchange Protein G7048_RS07170 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS07175 ENOG4105CHU acetyl-coa acetyltransferase G7048_RS07180 ENOG4105CF1 Alkylated DNA repair protein G7048_RS07190 ENOG4107R7Y intracellular protease Pfpi family G7048_RS07200 ENOG4108MEJ flavin reductase domain protein G7048_RS07210 ENOG4108JJA ABC, transporter G7048_RS07215 ENOG4105DFG type I secretion outer membrane protein G7048_RS07235 ENOG4105EW9 transcriptional regulator AsnC family G7048_RS07250 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G7048_RS07260 ENOG4105ETT transcriptional Regulator, LysR family G7048_RS07280 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) G7048_RS07285 ENOG4108YX9 iron--sulfur cluster insertion protein erpA G7048_RS07290 ENOG4108UJD 30S ribosomal protein S9 G7048_RS07295 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) G7048_RS07300 ENOG4105D9P serine threonine protein kinase G7048_RS07305 ENOG4105D6S protein involved in catabolism of external DNA G7048_RS07315 ENOG4105SYT Methylenetetrahydrofolate reductase G7048_RS07325 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G7048_RS07330 ENOG4105EEX Two component transcriptional regulator (Winged helix family G7048_RS07335 ENOG4105C08 Histidine kinase G7048_RS07340 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G7048_RS07345 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G7048_RS07350 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G7048_RS07360 ENOG4105D94 Major Facilitator Superfamily G7048_RS07370 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) G7048_RS07385 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) G7048_RS07405 ENOG4105CDA abc transporter atp-binding protein G7048_RS07410 ENOG4105DRP amino acid AbC transporter G7048_RS07415 ENOG4105EAD ABC transporter G7048_RS07420 ENOG4107RP9 extracellular solute-binding protein, family 3 G7048_RS07430 ENOG4107YNJ LysR family Transcriptional regulator G7048_RS07440 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G7048_RS07445 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G7048_RS07450 ENOG4107RUY (E1 component), alpha subunit G7048_RS07455 ENOG4105CPP Dehydrogenase, E1 component G7048_RS07460 ENOG4108JJ7 ABC transporter G7048_RS07465 ENOG4105NAU thioesterase Superfamily protein G7048_RS07475 ENOG4108VUY thioesterase Superfamily protein G7048_RS07480 ENOG41060WC Enoyl-CoA hydratase G7048_RS07490 ENOG4105CHU acetyl-coa acetyltransferase G7048_RS07505 ENOG4105CSU acyl-Coa dehydrogenase G7048_RS07520 ENOG4105CAS nag kinase G7048_RS07545 ENOG4108YRB methyltransferase G7048_RS07555 ENOG4105EY8 ABC transporter G7048_RS07565 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) G7048_RS07580 ENOG4105GVR general secretion pathway protein D G7048_RS07620 ENOG4108VAU general secretion pathway protein G G7048_RS07625 ENOG4105D7Q type ii secretion system G7048_RS07630 ENOG4107QHF type ii secretion system protein e G7048_RS07640 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase G7048_RS07650 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase G7048_RS07670 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) G7048_RS07675 ENOG4109066 lysm domain bon superfamily protein G7048_RS07695 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase G7048_RS07700 ENOG4105C38 Glycyl-tRNA synthetase beta subunit G7048_RS07705 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit G7048_RS07715 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) G7048_RS07720 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) G7048_RS07725 ENOG4108JU5 Magnesium and cobalt efflux protein G7048_RS07765 ENOG4105MIR Phenylalanine 4-monooxygenase G7048_RS07775 ENOG4107U32 Beta-lactamase domain protein G7048_RS07785 ENOG4108ESX Receptor G7048_RS07790 ENOG4107E2E PKHD-type hydroxylase G7048_RS07805 ENOG4107SC1 transglycosylase G7048_RS07810 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase G7048_RS07815 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) G7048_RS07825 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G7048_RS07840 ENOG4108K4C ec 3.1.3.12 G7048_RS07845 ENOG4105BZP glycoside hydrolase 15-related G7048_RS07850 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase G7048_RS07860 ENOG4105CSR polyphosphate kinase 2 G7048_RS07890 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) G7048_RS07915 ENOG4105DEG Vwa containing coxe family protein G7048_RS07930 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G7048_RS07935 ENOG4105KKX ATPase associated with various cellular activities aaa_5 G7048_RS07965 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic G7048_RS07980 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G7048_RS07985 ENOG4105DRR Transcriptional regulator, GntR family G7048_RS08000 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) G7048_RS08005 ENOG4105E7W lamb ycsf family protein G7048_RS08010 ENOG4105P4J Allophanate hydrolase, subunit 1 G7048_RS08015 ENOG4108JIK carboxylase G7048_RS08035 ENOG4105CFG Acts as a chaperone (By similarity) G7048_RS08065 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) G7048_RS08070 ENOG4105C9A Phoh family G7048_RS08075 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) G7048_RS08080 ENOG4105EJ9 Membrane G7048_RS08085 ENOG4107RSM transcriptional regulator G7048_RS08105 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) G7048_RS08115 ENOG4105FYV Amp nucleosidase G7048_RS08125 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G7048_RS08130 ENOG4105CNV Aldolase G7048_RS08145 ENOG4105E27 serine threonine protein kinase G7048_RS08165 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G7048_RS08170 ENOG4105FE9 pseudouridine synthase G7048_RS08175 ENOG4105IJJ transcriptional regulator, crp fnr family G7048_RS08190 ENOG4108IQE Amp-dependent synthetase and ligase G7048_RS08195 ENOG4105C0Z ABC transporter G7048_RS08200 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS08215 ENOG4108IV0 ABC, transporter G7048_RS08220 ENOG4105DZS Phenylacetate-CoA ligase G7048_RS08235 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G7048_RS08245 ENOG4108R3E Dna-3-methyladenine glycosylase i G7048_RS08265 ENOG4105CH2 amidohydrolase G7048_RS08275 ENOG4108J2R molybdopterin oxidoreductase G7048_RS08325 ENOG4108KK1 membrane protein AbrB duplication G7048_RS08330 ENOG4105NSG hemerythrin hhe cation binding domain protein G7048_RS08350 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G7048_RS08355 ENOG4105D0D Nitrate reductase 2, gamma subunit G7048_RS08360 ENOG4105R3A Nitrate reductase G7048_RS08365 ENOG4108IUE nitrate reductase beta subunit G7048_RS08370 ENOG4105CRU nitrate reductase, alpha subunit G7048_RS08375 ENOG4105DQQ Major facilitator superfamily MFS_1 G7048_RS08385 ENOG4105WH1 Two component transcriptional regulator luxr family G7048_RS08390 ENOG4105BZU Histidine kinase G7048_RS08415 ENOG4105CQB FAD linked oxidase domain protein G7048_RS08425 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G7048_RS08450 ENOG4106BRA Membrane G7048_RS08455 ENOG4108V1T peptidylprolyl cis-trans isomerase G7048_RS08465 ENOG4105DFA alanine racemase domain protein G7048_RS08470 ENOG4105CZX twitching motility protein G7048_RS08475 ENOG4105IJJ transcriptional regulator, crp fnr family G7048_RS08480 ENOG4105CZX twitching motility protein G7048_RS08485 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G7048_RS08490 ENOG4105W4M Transport-associated protein G7048_RS08495 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) G7048_RS08500 ENOG41082RQ UPF0102 protein G7048_RS08505 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G7048_RS08520 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS08530 ENOG4108IV0 ABC, transporter G7048_RS08535 ENOG4105C0Z ABC transporter G7048_RS08540 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS08545 ENOG4105CP9 extracellular ligand-binding receptor G7048_RS08550 ENOG4105R8A Heat shock protein G7048_RS08560 ENOG4108ZT0 50S ribosomal protein l17 G7048_RS08565 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G7048_RS08570 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) G7048_RS08575 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) G7048_RS08580 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits G7048_RS08585 ENOG41067V7 50S ribosomal protein L36 G7048_RS08590 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) G7048_RS08595 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) G7048_RS08600 ENOG4105VPB 50S ribosomal protein L30 G7048_RS08605 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) G7048_RS08610 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) G7048_RS08615 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) G7048_RS08620 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) G7048_RS08625 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G7048_RS08630 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits G7048_RS08635 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) G7048_RS08640 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) G7048_RS08645 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G7048_RS08660 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component G7048_RS08670 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G7048_RS08675 ENOG4108IJ9 (ABC) transporter G7048_RS08680 ENOG4105E98 transcriptional regulator DeoR family G7048_RS08685 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G7048_RS08690 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G7048_RS08700 ENOG4105II7 pyrroline-5-carboxylate reductase G7048_RS08720 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G7048_RS08725 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) G7048_RS08730 ENOG4105C5Q Transcriptional regulator G7048_RS08735 ENOG4105CB5 ATP-dependent DNA helicase recG G7048_RS08760 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G7048_RS08770 ENOG4105DND Transcriptional regulator G7048_RS08775 ENOG4108HPI phosphatidate Cytidylyltransferase G7048_RS08790 ENOG41077RS Phosphatase G7048_RS08795 ENOG4105E8V Alpha Beta Hydrolase Fold protein G7048_RS08800 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase G7048_RS08805 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G7048_RS08820 ENOG4105DK0 Indole-3-glycerol phosphate synthase G7048_RS08825 ENOG4107QYG anthranilate phosphoribosyltransferase G7048_RS08830 ENOG4105DDQ anthranilate synthase G7048_RS08850 ENOG4105C8Q Methyl-accepting chemotaxis G7048_RS08860 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G7048_RS08870 ENOG4105DJV ribulose-phosphate 3-epimerase G7048_RS08875 ENOG4105NWN ApaG protein G7048_RS08890 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) G7048_RS08905 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) G7048_RS08915 ENOG4108ZAI phosphatidylglycerophosphatase a G7048_RS08920 ENOG4107TH8 cina domain protein G7048_RS08925 ENOG4106RHG Yeca family G7048_RS08930 ENOG4105CBC glutamate synthase G7048_RS08945 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS08955 ENOG4105CHU acetyl-coa acetyltransferase G7048_RS08965 ENOG4105E39 Enoyl-CoA hydratase G7048_RS08995 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G7048_RS09000 ENOG4105KPY Small multidrug resistance protein G7048_RS09015 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) G7048_RS09020 ENOG4108Z7R Chaperone CsaA G7048_RS09040 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G7048_RS09045 ENOG4108IUZ ABC transporter G7048_RS09050 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA G7048_RS09065 ENOG4105C75 arginyL-tRNA synthetase G7048_RS09095 ENOG4105BZU Histidine kinase G7048_RS09100 ENOG4108KXV response regulator G7048_RS09110 ENOG4107QP3 malate synthase g G7048_RS09125 ENOG410802X bacteriophage n4 adsorption protein b G7048_RS09135 ENOG4108XTA Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate G7048_RS09145 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein G7048_RS09150 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G7048_RS09155 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) G7048_RS09185 ENOG41084KP 4-oxalocrotonate tautomerase G7048_RS09195 ENOG4105E7A Glutamine amidotransferase G7048_RS09205 ENOG4105CHR reductase G7048_RS09230 ENOG4105C1P efflux transporter, rnd family, mfp subunit G7048_RS09240 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G7048_RS09265 ENOG41085FR LemA family G7048_RS09345 ENOG41083UI stage II sporulation protein G7048_RS09485 ENOG4105EMN RNA polymerase sigma factor G7048_RS09505 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) G7048_RS09510 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) G7048_RS09515 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) G7048_RS09520 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) G7048_RS09525 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G7048_RS09530 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G7048_RS09535 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G7048_RS09540 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) G7048_RS09550 ENOG4108Z43 UPF0250 protein G7048_RS09555 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G7048_RS09560 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G7048_RS09565 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G7048_RS09580 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G7048_RS09585 ENOG41080Z8 PHOSPHOCARRIER protein G7048_RS09600 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G7048_RS09605 ENOG4105T86 cytochrome C G7048_RS09620 ENOG4105EWC Purine nucleoside phosphorylase G7048_RS09625 ENOG4105CHR reductase G7048_RS09640 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal G7048_RS09645 ENOG41084PQ 50s ribosomal protein l29 G7048_RS09650 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) G7048_RS09655 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) G7048_RS09660 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) G7048_RS09665 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) G7048_RS09670 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity G7048_RS09675 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) G7048_RS09680 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) G7048_RS09685 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G7048_RS09690 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) G7048_RS09695 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G7048_RS09700 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G7048_RS09705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) G7048_RS09710 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) G7048_RS09715 ENOG4105DZ1 carboxypeptidase G7048_RS09720 ENOG4105DHZ alpha beta G7048_RS09740 ENOG4108K0D peptidase, M48 G7048_RS09745 ENOG4105D52 delta-aminolevulinic acid dehydratase G7048_RS09750 ENOG4105D7N magnesium and cobalt transport protein CorA G7048_RS09760 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G7048_RS09765 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein G7048_RS09770 ENOG4105E3W Two component transcriptional regulator (Winged helix family G7048_RS09775 ENOG4105EB3 Histidine kinase G7048_RS09780 ENOG4105CT7 inner membrane cred family protein G7048_RS09795 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G7048_RS09805 ENOG4105BZU Histidine kinase G7048_RS09820 ENOG4105CQB FAD linked oxidase domain protein G7048_RS09845 ENOG4105MRD Phage derived protein Gp49-like (DUF891) G7048_RS09850 ENOG4105DRR Transcriptional regulator, GntR family G7048_RS09865 ENOG4105DHJ ABC, transporter G7048_RS09895 ENOG4105EAB amino acid AbC transporter G7048_RS09900 ENOG4105E5Q amino acid AbC transporter G7048_RS09925 ENOG4105CJN penicillin-binding protein G7048_RS09945 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G7048_RS09950 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G7048_RS09955 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G7048_RS09975 ENOG4105BZU Histidine kinase G7048_RS09985 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) G7048_RS09990 ENOG4105CGK Exodeoxyribonuclease III G7048_RS09995 ENOG4105NIV Esterase G7048_RS10010 ENOG4105CHR reductase G7048_RS10015 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS10025 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G7048_RS10050 ENOG41090MY MarR family Transcriptional regulator G7048_RS10055 ENOG4105CSU acyl-Coa dehydrogenase G7048_RS10070 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase G7048_RS10080 ENOG4105VYA Uncharacterized conserved protein (DUF2132) G7048_RS10085 ENOG4106611 bacteriocin immunity G7048_RS10105 ENOG4105C5X domain protein G7048_RS10110 ENOG4105D0M Protease HtpX homolog G7048_RS10135 ENOG4105JJR Histidine kinase G7048_RS10140 ENOG4105CBP Major Facilitator G7048_RS10145 ENOG4105EGI Transcriptional regulator G7048_RS10150 ENOG4107QWG 2-Nitropropane dioxygenase G7048_RS10185 ENOG4105CM2 brancheD-chain amino acid aminotransferase G7048_RS10205 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G7048_RS10230 ENOG4108V8F Transcriptional regulator, MarR family G7048_RS10235 ENOG4105ERH Fumarylacetoacetate hydrolase G7048_RS10245 ENOG4105C26 Dehydrogenase G7048_RS10270 ENOG4108IV0 ABC, transporter G7048_RS10275 ENOG4105C0Z ABC transporter G7048_RS10295 ENOG4105CA0 peroxidase G7048_RS10305 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G7048_RS10320 ENOG4108V06 Glutathione peroxidase G7048_RS10350 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G7048_RS10355 ENOG4105EU8 FAD linked oxidase domain protein G7048_RS10370 ENOG4105BZU Histidine kinase G7048_RS10375 ENOG4108YZA Nitrogen regulatory protein pii G7048_RS10385 ENOG4105C0P Mg chelatase subunit ChlI G7048_RS10400 ENOG4108IV0 ABC, transporter G7048_RS10405 ENOG4105C0Z ABC transporter G7048_RS10410 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS10415 ENOG4108SY4 MarR family Transcriptional regulator G7048_RS10420 ENOG4105CHR reductase G7048_RS10425 ENOG4108IPT Naphthoate synthase G7048_RS10435 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS10440 ENOG4105CP9 extracellular ligand-binding receptor G7048_RS10445 ENOG4105DP0 ferredoxin-NADP reductase G7048_RS10460 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G7048_RS10470 ENOG4105C26 Dehydrogenase G7048_RS10480 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G7048_RS10485 ENOG4108KB2 LysR family Transcriptional regulator G7048_RS10495 ENOG4105ENE Histidine kinase G7048_RS10500 ENOG41067MG lrgb family G7048_RS10510 ENOG4105CMU LysR family (Transcriptional regulator G7048_RS10545 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G7048_RS10575 ENOG4105E1J oxidoreductase G7048_RS10580 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G7048_RS10585 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G7048_RS10590 ENOG4105C3U ABC transporter G7048_RS10595 ENOG4108JQ7 (ABC) transporter G7048_RS10600 ENOG4105DEF Extracellular solute-binding protein, family 5 G7048_RS10620 ENOG4105CK2 sodium dicarboxylate symporter G7048_RS10630 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G7048_RS10645 ENOG4108QXE glycerophosphoryl diester phosphodiesterase G7048_RS10650 ENOG4107QRP cobalamin biosynthesis protein CobW G7048_RS10655 ENOG4105CTK cobaltochelatase, cobn subunit G7048_RS10670 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein G7048_RS10710 ENOG4105DND Transcriptional regulator G7048_RS10730 ENOG4105EQ1 Transcriptional regulator G7048_RS10760 ENOG4105EQ0 Major Facilitator superfamily G7048_RS10765 ENOG4105CSR polyphosphate kinase 2 G7048_RS10770 ENOG4105D82 Glutamate dehydrogenase G7048_RS10790 ENOG4105FDP GntR family transcriptional regulator G7048_RS10795 ENOG4105R1U AraC Family Transcriptional Regulator G7048_RS10800 ENOG4105EU0 Major facilitator Superfamily G7048_RS10810 ENOG4108K88 Membrane G7048_RS10815 ENOG4105FC8 fad dependent oxidoreductase G7048_RS10825 ENOG4108FUF Transcriptional regulator, IclR family G7048_RS10830 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G7048_RS10860 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS10865 ENOG4108M9J MaoC like domain protein G7048_RS10895 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) G7048_RS10905 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) G7048_RS10950 ENOG4105C7B Threonine dehydratase G7048_RS10955 ENOG4105CSU acyl-Coa dehydrogenase G7048_RS10960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G7048_RS10970 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G7048_RS10975 ENOG4108JPW Aminotransferase G7048_RS10985 ENOG4105C3R Methionine synthase G7048_RS10990 ENOG4105C9U ATP-dependent DNA helicase RecQ G7048_RS10995 ENOG4105ES4 Nitrilase G7048_RS11025 ENOG4105EJQ L-serine dehydratase G7048_RS11050 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) G7048_RS11055 ENOG4105MWK D-amino acid dehydrogenase, small subunit G7048_RS11090 ENOG4106HB6 Alpha beta hydrolase G7048_RS11100 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) G7048_RS11105 ENOG4107QMS site-determining protein G7048_RS11110 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) G7048_RS11120 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase G7048_RS11130 ENOG4105D2B acyl-CoA dehydrogenase G7048_RS11135 ENOG4105D2B acyl-CoA dehydrogenase G7048_RS11140 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS11150 ENOG4105CN8 Transcriptional regulator G7048_RS11190 ENOG4105E39 Enoyl-CoA hydratase G7048_RS11195 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS11205 ENOG4105C2W permease G7048_RS11220 ENOG4105KA0 thioesterase Superfamily protein G7048_RS11235 ENOG4107RP9 extracellular solute-binding protein, family 3 G7048_RS11240 ENOG4105MWK D-amino acid dehydrogenase, small subunit G7048_RS11250 ENOG4108WBT adenosyltransferase G7048_RS11260 ENOG4105CQB FAD linked oxidase domain protein G7048_RS11285 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G7048_RS11300 ENOG4107T8P acyl-Coa dehydrogenase G7048_RS11305 ENOG4107T8P acyl-Coa dehydrogenase G7048_RS11355 ENOG4105KCV RNA signal recognition particle 4.5S RNA G7048_RS11365 ENOG4107XWI flavin reductase domain protein, FMN-binding G7048_RS11380 ENOG4105FA0 parb-like partition protein G7048_RS11390 ENOG4107QJE Chromosome Partitioning Protein G7048_RS11400 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) G7048_RS11405 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G7048_RS11410 ENOG4108K3A Glutathione S-transferase G7048_RS11415 ENOG4108R85 Short chain dehydrogenase G7048_RS11420 ENOG4105ERH Fumarylacetoacetate hydrolase G7048_RS11440 ENOG4108YYH Nadph-dependent fmn reductase G7048_RS11445 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G7048_RS11475 ENOG4105C59 p-type ATPase G7048_RS11480 ENOG4105CHB tonB-dependent Receptor G7048_RS11490 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family G7048_RS11525 ENOG4107S7U Sulfide dehydrogenase G7048_RS11535 ENOG4105W2Z cytochrome C, class I G7048_RS11560 ENOG4108M0I Transcriptional regulator G7048_RS11570 ENOG4105C5I Dehydrogenase G7048_RS11580 ENOG4108JIC nucleoside recognition domain protein G7048_RS11610 ENOG4105CK2 sodium dicarboxylate symporter G7048_RS11615 ENOG4105DH7 May be involved in recombination (By similarity) G7048_RS11660 ENOG4105CC9 acyl-Coa dehydrogenase G7048_RS11665 ENOG4105D2B acyl-CoA dehydrogenase G7048_RS11670 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G7048_RS11680 ENOG4105K4H Nlp p60 protein G7048_RS11685 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G7048_RS11690 ENOG4105CSW GntR family transcriptional regulator G7048_RS11700 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) G7048_RS11715 ENOG4105DVT helicase G7048_RS11720 ENOG4107QKA exodeoxyribonuclease V beta G7048_RS11725 ENOG4105D6E homoserine dehydrogenase G7048_RS11735 ENOG4105I5W Transporter G7048_RS11745 ENOG4105D7T ABC transporter G7048_RS11750 ENOG4108IFG nitrite reductase, (NAD(P)H) G7048_RS11755 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit G7048_RS11765 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G7048_RS11770 ENOG4108Z9K Osmotically inducible protein G7048_RS11795 ENOG4105BZU Histidine kinase G7048_RS11810 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G7048_RS11815 ENOG4108IV0 ABC, transporter G7048_RS11820 ENOG4105C0Z ABC transporter G7048_RS11830 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS11835 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein G7048_RS11840 ENOG4108YZ9 Urea amidohydrolase subunit gamma G7048_RS11850 ENOG4105KI2 Urea amidohydrolase subunit beta G7048_RS11855 ENOG4105CQM Urea amidohydrolase subunit alpha G7048_RS11865 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) G7048_RS11870 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G7048_RS11875 ENOG4105KAC Antibiotic biosynthesis monooxygenase G7048_RS11880 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) G7048_RS11885 ENOG4105J4Q Transcriptional regulator G7048_RS11900 ENOG4108VUG Enoyl-CoA hydratase G7048_RS11905 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS11910 ENOG4108T2C cysteine dioxygenase type I G7048_RS11920 ENOG4105E39 Enoyl-CoA hydratase G7048_RS11930 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP G7048_RS11935 ENOG410756H nucleotidyltransferase G7048_RS11940 ENOG4105E0Y RtcB Protein G7048_RS11950 ENOG4105CYB regulatoR G7048_RS11955 ENOG4105EAB amino acid AbC transporter G7048_RS11960 ENOG4105E5Q amino acid AbC transporter G7048_RS11965 ENOG4105DRP amino acid AbC transporter G7048_RS11985 ENOG4105CHH sulfate transporter G7048_RS11995 ENOG4105FA0 parb-like partition protein G7048_RS12080 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G7048_RS12085 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G7048_RS12090 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G7048_RS12095 ENOG4105VG0 50S ribosomal protein l34 G7048_RS12100 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) G7048_RS12105 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) G7048_RS12110 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G7048_RS12115 ENOG4107QSI ABC, transporter G7048_RS12120 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) G7048_RS12125 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G7048_RS12140 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) G7048_RS12150 ENOG4105C2X Arabinose 5-phosphate isomerase G7048_RS12155 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase G7048_RS12165 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G7048_RS12170 ENOG4105VFU Rna-binding protein G7048_RS12175 ENOG4105VFU Rna-binding protein G7048_RS12185 ENOG4105DWV Homoserine O-trans-acetylase G7048_RS12200 ENOG4105E8V Alpha Beta Hydrolase Fold protein G7048_RS12215 ENOG4107MBT Plasmid stabilisation system protein G7048_RS12220 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G7048_RS12235 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) G7048_RS12240 ENOG4105EHM Aminoglycoside phosphotransferase G7048_RS12245 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) G7048_RS12250 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G7048_RS12255 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G7048_RS12275 ENOG4105C6K Malic enzyme G7048_RS12305 ENOG4108MGI Transcriptional regulator G7048_RS12310 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G7048_RS12320 ENOG4108R6K riboflavin synthase, subunit alpha G7048_RS12370 ENOG4107258 Transcriptional regulator G7048_RS12375 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G7048_RS12380 ENOG4105D8K carboxyl transferase G7048_RS12385 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G7048_RS12390 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit G7048_RS12395 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G7048_RS12415 ENOG4107QNJ CoA-transferase subunit B G7048_RS12420 ENOG4108KX4 response regulator G7048_RS12425 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G7048_RS12430 ENOG4108KS2 transglutaminase domain protein G7048_RS12435 ENOG4105EVZ LysR family transcriptional regulator G7048_RS12440 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G7048_RS12445 ENOG4105C26 Dehydrogenase G7048_RS12455 ENOG4108PVQ transcriptional regulator G7048_RS12465 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS12470 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G7048_RS12475 ENOG4105C0Z ABC transporter G7048_RS12480 ENOG4108IV0 ABC, transporter G7048_RS12490 ENOG4107TFB basic membrane G7048_RS12495 ENOG4108JQ9 ABC transporter G7048_RS12500 ENOG4105UIB (ABC) transporter G7048_RS12510 ENOG4105DZC cytosine deaminase G7048_RS12530 ENOG4105MP9 class II Aldolase G7048_RS12535 ENOG41079YP Citrate utilization protein b G7048_RS12545 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G7048_RS12555 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS12595 ENOG4105F7F Chaperone G7048_RS12605 ENOG4108Z9W Outer membrane porin G7048_RS12610 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) G7048_RS12615 ENOG4105DAA L-lactate G7048_RS12625 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G7048_RS12630 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G7048_RS12635 ENOG41060W2 glyoxylate carboligase G7048_RS12640 ENOG4105CC0 LysR family Transcriptional regulator G7048_RS12645 ENOG4105E98 transcriptional regulator DeoR family G7048_RS12650 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G7048_RS12655 ENOG4105C0A alcohol dehydrogenase G7048_RS12660 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G7048_RS12665 ENOG4107S2N Type III effector Hrp-dependent G7048_RS12680 ENOG4105BZU Histidine kinase G7048_RS12685 ENOG4108UUM single-stranded DNA-binding protein G7048_RS12690 ENOG4107RDB Major Facilitator G7048_RS12710 ENOG4105C26 Dehydrogenase G7048_RS12735 ENOG4105SKN orotidine 5''-phosphate decarboxylase G7048_RS12740 ENOG4108594 Permease of the drug metabolite transporter G7048_RS12755 ENOG4105BZA Phosphoglycerate kinase G7048_RS12770 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G7048_RS12780 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G7048_RS12790 ENOG4105C79 DNA protecting protein DprA G7048_RS12795 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G7048_RS12800 ENOG4105CMV Succinyl-CoA synthetase subunit beta G7048_RS12805 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G7048_RS12810 ENOG4108ZCF integral membrane protein G7048_RS12815 ENOG4108ZCF integral membrane protein G7048_RS12825 ENOG4108UW8 fha domain-containing protein G7048_RS12835 ENOG4105YWY G7048_RS12845 ENOG4108I6E Sulfatase G7048_RS12865 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G7048_RS12870 ENOG4105ERG peptidase m48, ste24p G7048_RS12875 ENOG41086DT Membrane protein of unknown function G7048_RS12885 ENOG4108ZCF integral membrane protein G7048_RS12900 ENOG4108VWS Yaeq family G7048_RS12905 ENOG4107QTF adenylosuccinate lyase G7048_RS12910 ENOG4108U78 Glutathione S-transferase G7048_RS12930 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) G7048_RS12945 ENOG4105BZU Histidine kinase G7048_RS12950 ENOG4108ZXC Two component transcriptional regulator, luxr family G7048_RS12960 ENOG4105CA3 membrane-bound lytic murein transglycosylase G7048_RS12975 ENOG4105F7P transcriptional regulator AsnC family G7048_RS12990 ENOG4105VIE preprotein translocase, subunit YajC G7048_RS12995 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G7048_RS13000 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G7048_RS13015 ENOG4108004 Modulates RecA activity (By similarity) G7048_RS13020 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) G7048_RS13030 ENOG4105CJP fad dependent oxidoreductase G7048_RS13050 ENOG4107XBN GntR Family Transcriptional Regulator G7048_RS13055 ENOG4105C4Y ABC transporter G7048_RS13080 ENOG4105DHQ Histidine kinase G7048_RS13085 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G7048_RS13095 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS13105 ENOG4108M9J MaoC like domain protein G7048_RS13110 ENOG4105CHR reductase G7048_RS13115 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G7048_RS13120 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS13130 ENOG4105C0Z ABC transporter G7048_RS13135 ENOG4108IV0 ABC, transporter G7048_RS13140 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis G7048_RS13160 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS13180 ENOG4108WYP Transcriptional regulator G7048_RS13205 ENOG4105C9U ATP-dependent DNA helicase RecQ G7048_RS13230 ENOG4105Y49 secretion protein, HlyD family G7048_RS13240 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) G7048_RS13265 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G7048_RS13270 ENOG4105C26 Dehydrogenase G7048_RS13285 ENOG4106IUH DTW domain containing protein G7048_RS13300 ENOG4107TVC Glycosyl transferase, family 2 G7048_RS13325 ENOG4105CD5 CoA-binding domain protein G7048_RS13340 ENOG4105CHU acetyl-coa acetyltransferase G7048_RS13370 ENOG4108YZY peptidylprolyl cis-trans isomerase G7048_RS13395 ENOG4108ZG0 Ompa motb domain protein G7048_RS13405 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G7048_RS13410 ENOG4105CV1 Transketolase (EC 2.2.1.1) G7048_RS13415 ENOG4108S0S Nucleotidyl transferase G7048_RS13425 ENOG4107RAQ aminopeptidase G7048_RS13480 ENOG4105KHM amidohydrolase 2 G7048_RS13490 ENOG4105ERH Fumarylacetoacetate hydrolase G7048_RS13520 ENOG4108S2Y peptide Chain Release factor G7048_RS13525 ENOG4105CA9 Pyruvate kinase G7048_RS13535 ENOG4105D2N Aldolase G7048_RS13540 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G7048_RS13550 ENOG4105W8H transhydrogenase (subunit alpha G7048_RS13555 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G7048_RS13560 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS13565 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) G7048_RS13570 ENOG4107QUT magnesium and cobalt transport protein CorA G7048_RS13585 ENOG41072GX Peptidase M22 Glycoprotease G7048_RS13610 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G7048_RS13615 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G7048_RS13620 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G7048_RS13625 ENOG4105K63 Thioredoxin G7048_RS13635 ENOG4105C8V SAICAR synthetase G7048_RS13640 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA G7048_RS13645 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN G7048_RS13650 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) G7048_RS13655 ENOG41090R7 Ferric uptake G7048_RS13660 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G7048_RS13665 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G7048_RS13675 ENOG4105SG9 biopolymer transport protein, ExbD G7048_RS13690 ENOG4105CUY Mechanosensitive ion channel G7048_RS13695 ENOG4105C8T Leucyl-tRNA synthetase G7048_RS13720 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS13725 ENOG4105CHR reductase G7048_RS13735 ENOG410900P UPF0336 protein G7048_RS13745 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS13755 ENOG4105W06 Cupin 2, conserved barrel domain protein G7048_RS13760 ENOG4108JQB penicillin-binding protein 1C G7048_RS13765 ENOG4105DN3 alpha-2-macroglobulin domain protein G7048_RS13780 ENOG4105D5T phosphonate abc transporter G7048_RS13805 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G7048_RS13810 ENOG4105C1A potassium transporter peripheral membrane G7048_RS13815 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) G7048_RS13825 ENOG4105DFH Transport of potassium into the cell (By similarity) G7048_RS13830 ENOG4105DKK Benzoate G7048_RS13835 ENOG4105D7Z glutathione synthase G7048_RS13885 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G7048_RS13905 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) G7048_RS13910 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) G7048_RS13915 ENOG4108VZM 50s ribosomal protein L10 G7048_RS13920 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) G7048_RS13925 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G7048_RS13930 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G7048_RS13940 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G7048_RS13950 ENOG4105ES5 Histidine kinase G7048_RS14015 ENOG4108KU3 Integrase G7048_RS14020 ENOG4108KPJ rna polymerase sigma factor G7048_RS14025 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G7048_RS14040 ENOG4105M2Z protein tyrosine serine phosphatase G7048_RS14075 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS14100 ENOG4105BZU Histidine kinase G7048_RS14105 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) G7048_RS14135 ENOG4108UKI Enoyl-CoA hydratase G7048_RS14140 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS14160 ENOG4105HDD phospholipase G7048_RS14170 ENOG4105C4R Atp-dependent dna helicase G7048_RS14195 ENOG4105RK9 auxin efflux carrier G7048_RS14220 ENOG4105C25 Primosomal protein n' G7048_RS14225 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) G7048_RS14245 ENOG4105K4P CoA-binding domain protein G7048_RS14250 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G7048_RS14260 ENOG4105BZU Histidine kinase G7048_RS14265 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G7048_RS14280 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein G7048_RS14290 ENOG4108UKI Enoyl-CoA hydratase G7048_RS14295 ENOG4108ZJI phenylacetic acid degradation protein G7048_RS14305 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit G7048_RS14310 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit G7048_RS14315 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit G7048_RS14320 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit G7048_RS14325 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G7048_RS14335 ENOG4107QJQ Mate efflux family protein G7048_RS14380 ENOG4105JAB phenazine biosynthesis protein, phzf family G7048_RS14390 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G7048_RS14410 ENOG4107YTP response regulator receiver protein G7048_RS14415 ENOG4105CBS Chea signal transduction histidine kinase G7048_RS14420 ENOG4108V3W Chemotaxis protein, CheW G7048_RS14425 ENOG4105BZU Histidine kinase G7048_RS14430 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) G7048_RS14435 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G7048_RS14440 ENOG4105C5H ABC transporter G7048_RS14470 ENOG4108Z6Z Transcriptional regulator G7048_RS14475 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS14480 ENOG41077A9 carbonic anhydrase G7048_RS14485 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) G7048_RS14490 ENOG4105CHU acetyl-coa acetyltransferase G7048_RS14505 ENOG4108RU0 short-chain dehydrogenase reductase G7048_RS14510 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS14515 ENOG4107VMU Membrane G7048_RS14525 ENOG4105K5B UPF0225 protein G7048_RS14530 ENOG4105BZU Histidine kinase G7048_RS14550 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 G7048_RS14560 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS14570 ENOG4105EEQ Na H antiporter G7048_RS14575 ENOG4107QX3 carboxylase G7048_RS14580 ENOG41060WC Enoyl-CoA hydratase G7048_RS14595 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase G7048_RS14600 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G7048_RS14640 ENOG4105CSH Transporter G7048_RS14645 ENOG4108Z9W Outer membrane porin G7048_RS14665 ENOG4105CP9 extracellular ligand-binding receptor G7048_RS14670 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G7048_RS14680 ENOG4105EKE dihydroorotase G7048_RS14695 ENOG4105D0M Protease HtpX homolog G7048_RS14710 ENOG4105EFA 4-hydroxyphenylacetate G7048_RS14720 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS14725 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G7048_RS14730 ENOG4105C0Z ABC transporter G7048_RS14735 ENOG4108IV0 ABC, transporter G7048_RS14740 ENOG4105H3G oxidoreductase G7048_RS14745 ENOG4105KME endoribonuclease L-psp G7048_RS14755 ENOG4105CWC Acetylornithine deacetylase G7048_RS14760 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS14770 ENOG4105EA8 2-Nitropropane dioxygenase G7048_RS14775 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS14780 ENOG4105DZ0 fad dependent oxidoreductase G7048_RS14785 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G7048_RS14820 ENOG4108M3P Membrane G7048_RS14835 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G7048_RS14840 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) G7048_RS14850 ENOG4108J6E Pfam:Phage_integr_N G7048_RS14855 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G7048_RS14865 ENOG4105DND Transcriptional regulator G7048_RS14875 ENOG4105D2S major facilitator superfamily G7048_RS14880 ENOG4105GAK amidohydrolase 2 G7048_RS14900 ENOG4105CPC Aldo Keto reductase G7048_RS14905 ENOG4107HP6 Transcriptional regulator G7048_RS14915 ENOG4105CKI cobalamin synthesis protein G7048_RS14930 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) G7048_RS14935 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) G7048_RS14940 ENOG4108V6E Cell division protein mraZ G7048_RS14945 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) G7048_RS14960 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G7048_RS14965 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) G7048_RS14970 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) G7048_RS14975 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) G7048_RS14980 ENOG4105CNI cell division protein FtsW G7048_RS14985 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G7048_RS14990 ENOG4105DFU Cell wall formation (By similarity) G7048_RS14995 ENOG4105CPF Cell wall formation (By similarity) G7048_RS15000 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) G7048_RS15005 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) G7048_RS15010 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G7048_RS15015 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G7048_RS15020 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G7048_RS15030 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) G7048_RS15040 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) G7048_RS15045 ENOG4108K2P TRANSCRIPTIONal G7048_RS15050 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase G7048_RS15055 ENOG4105E2X shikimate dehydrogenase G7048_RS15075 ENOG4105IPS esterase G7048_RS15080 ENOG4105CNI cell division protein FtsW G7048_RS15085 ENOG4105D1U peptidase U62 modulator of DNA gyrase G7048_RS15090 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G7048_RS15100 ENOG4105DFU Cell wall formation (By similarity) G7048_RS15110 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G7048_RS15115 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein G7048_RS15120 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G7048_RS15125 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G7048_RS15135 ENOG4107T4Z adenosine kinase G7048_RS15145 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G7048_RS15150 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G7048_RS15160 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G7048_RS15165 ENOG4107TUY Histidine kinase G7048_RS15180 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY G7048_RS15190 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G7048_RS15200 ENOG4108R1E Serine threonine protein phosphatase 1 G7048_RS15220 ENOG4105E39 Enoyl-CoA hydratase G7048_RS15245 ENOG4105C3G gtp-binding protein G7048_RS15250 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G7048_RS15255 ENOG4105D05 Receptor G7048_RS15280 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G7048_RS15295 ENOG4105W39 Membrane G7048_RS15300 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G7048_RS15305 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) G7048_RS15310 ENOG4105DC1 bifunctional purine biosynthesis protein purh G7048_RS15320 ENOG4105E0K tonB-dependent siderophore receptor G7048_RS15330 ENOG4105EHG Permease protein G7048_RS15335 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) G7048_RS15340 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G7048_RS15350 ENOG4105VCQ rubredoxin G7048_RS15355 ENOG4108UNF response regulator G7048_RS15360 ENOG4105M3Z response regulator G7048_RS15365 ENOG4108V3W Chemotaxis protein, CheW G7048_RS15370 ENOG4105C8Q Methyl-accepting chemotaxis G7048_RS15380 ENOG4108UJU UPF0301 protein G7048_RS15385 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G7048_RS15390 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) G7048_RS15395 ENOG4105CXT aspartate transcarbamylase G7048_RS15400 ENOG4105CD3 dihydroorotase G7048_RS15410 ENOG4105K89 arsenate reductase G7048_RS15425 ENOG4105C0H protease G7048_RS15430 ENOG4105XJC Two component transcriptional regulator (Winged helix family G7048_RS15435 ENOG4105DHQ Histidine kinase G7048_RS15440 ENOG4105EUB pirin domain protein G7048_RS15655 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G7048_RS15805 ENOG4105CFU surface antigen G7048_RS15820 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G7048_RS15825 ENOG4106RE7 Cytochrome G7048_RS15865 ENOG4107HP6 Transcriptional regulator G7048_RS15875 ENOG4107QNJ CoA-transferase subunit B G7048_RS15880 ENOG4105CHU acetyl-coa acetyltransferase G7048_RS15885 ENOG4105F2Z 3-oxoadipate enol-lactonase G7048_RS15900 ENOG410829K Lysine exporter protein (Lyse ygga) G7048_RS15905 ENOG4107SKI cobyrinic Acid a,c-diamide synthase G7048_RS15915 ENOG4105EXG Transcriptional regulator G7048_RS15920 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G7048_RS15925 ENOG4105MJ2 Competence protein G7048_RS15930 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G7048_RS15935 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) G7048_RS15945 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) G7048_RS15955 ENOG4107QS1 Cytochrome C Oxidase, Subunit III G7048_RS15980 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) G7048_RS15990 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G7048_RS15995 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G7048_RS16000 ENOG4105ES4 Nitrilase G7048_RS16045 ENOG4106H78 methyltransferase G7048_RS16055 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS16060 ENOG4105EG6 Saccharopine dehydrogenase G7048_RS16070 ENOG4105CHR reductase G7048_RS16085 ENOG4105EXG Transcriptional regulator G7048_RS16095 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) G7048_RS16105 ENOG4107RNH Outer membrane receptor FepA G7048_RS16120 ENOG4106H29 UPF0391 membrane protein G7048_RS16125 ENOG4105BZU Histidine kinase G7048_RS16130 ENOG4105WH1 Two component transcriptional regulator luxr family G7048_RS16140 ENOG4105D06 uba thif-type nad fad binding protein G7048_RS16145 ENOG4105CN1 protease G7048_RS16150 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G7048_RS16155 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) G7048_RS16165 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) G7048_RS16170 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G7048_RS16185 ENOG4105RQF LysR family Transcriptional regulator G7048_RS16195 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G7048_RS16235 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) G7048_RS16240 ENOG4105CRQ synthase (Component I) G7048_RS16270 ENOG4108JU7 Transcriptional regulator G7048_RS16305 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G7048_RS16365 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) G7048_RS16385 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit G7048_RS16405 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) G7048_RS16415 ENOG4105CE7 Amidase, hydantoinase carbamoylase family G7048_RS16420 ENOG4105CD3 dihydroorotase G7048_RS16425 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G7048_RS16430 ENOG4107SJI Dehydrogenase G7048_RS16435 ENOG4105BZ8 glutamate synthase G7048_RS16440 ENOG4108R86 Transcriptional regulator G7048_RS16460 ENOG4105C85 amino acid G7048_RS16470 ENOG4108VP3 Lysine exporter protein (LysE YggA) G7048_RS16480 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) G7048_RS16490 ENOG4105CHJ isochorismatase hydrolase G7048_RS16495 ENOG4105CC0 LysR family Transcriptional regulator G7048_RS16505 ENOG4105EM7 Selenocysteine-specific translation elongation factor G7048_RS16510 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) G7048_RS16515 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) G7048_RS16520 ENOG4108MG3 formate dehydrogenase G7048_RS16525 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G7048_RS16535 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G7048_RS16540 ENOG4105CV6 ABC transporter, permease G7048_RS16555 ENOG4105CGH 5'-nucleotidase G7048_RS16570 ENOG4105W5Q DNA repair protein (RadC G7048_RS16580 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) G7048_RS16590 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G7048_RS16600 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G7048_RS16605 ENOG4106F60 Histidine kinase G7048_RS16620 ENOG4107R0E Glycosyl transferase, family 2 G7048_RS16635 ENOG4105EUB pirin domain protein G7048_RS16640 ENOG4105EUB pirin domain protein G7048_RS16645 ENOG4105X1Q TOBE domain protein G7048_RS16650 ENOG4108R96 Methyltransferase, YaeB family G7048_RS16655 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G7048_RS16665 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G7048_RS16675 ENOG4107RP9 extracellular solute-binding protein, family 3 G7048_RS16680 ENOG4105CK2 sodium dicarboxylate symporter G7048_RS16685 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G7048_RS16690 ENOG4105HEI LysR family (Transcriptional regulator G7048_RS16695 ENOG4108XHQ (2Fe-2S)-binding domain protein G7048_RS16700 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding G7048_RS16705 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding G7048_RS16725 ENOG4105BZU Histidine kinase G7048_RS16735 ENOG4105HDK L-asparaginase G7048_RS16755 ENOG41061MV Arylsulfatase G7048_RS16760 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G7048_RS16765 ENOG4107R7I amino acid G7048_RS16770 ENOG4108Z9W Outer membrane porin G7048_RS16775 ENOG4105JJR Histidine kinase G7048_RS16795 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G7048_RS16805 ENOG4106FTQ Taurine ABC transporter, periplasmic G7048_RS16810 ENOG4105E2B Taurine dioxygenase G7048_RS16890 ENOG4105CHR reductase G7048_RS16905 ENOG4108FUF Transcriptional regulator, IclR family G7048_RS16920 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G7048_RS16930 ENOG4106FTQ Taurine ABC transporter, periplasmic G7048_RS16935 ENOG4105MWK D-amino acid dehydrogenase, small subunit G7048_RS16945 ENOG4105C85 amino acid G7048_RS16950 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G7048_RS16960 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G7048_RS16970 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class G7048_RS16975 ENOG4105BZU Histidine kinase G7048_RS16985 ENOG4108KXV response regulator G7048_RS16990 ENOG4105C31 Tryptophanyl-tRNA synthetase G7048_RS16995 ENOG4108Z4T Peptidase M50 G7048_RS17000 ENOG4107RTD sua5 ycio yrdc ywlc family protein G7048_RS17005 ENOG4105DB7 PHP domain protein G7048_RS17015 ENOG4105CBN LysR family transcriptional regulator G7048_RS17020 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G7048_RS17030 ENOG4105D60 lipoprotein releasing system transmembrane protein G7048_RS17035 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G7048_RS17040 ENOG4107QVM von Willebrand factor, type A G7048_RS17050 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G7048_RS17055 ENOG4105C0H protease G7048_RS17060 ENOG4105EYA deoxyribonuclease G7048_RS17070 ENOG4105I7M spermidine synthase G7048_RS17075 ENOG4107QHF type ii secretion system protein e G7048_RS17090 ENOG4106UX7 integral membrane protein G7048_RS17095 ENOG4105CHR reductase G7048_RS17105 ENOG4105CUV Homoserine Kinase G7048_RS17115 ENOG4105C2M dna polymerase I G7048_RS17130 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) G7048_RS17140 ENOG4108NEV two component transcriptional regulator, LytTR family G7048_RS17145 ENOG4108HRK Histidine kinase G7048_RS17150 ENOG4105CH7 arginosuccinase G7048_RS17155 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G7048_RS17180 ENOG4105BZ4 penicillin-binding protein G7048_RS17190 ENOG4105DMF Dehydrogenase G7048_RS17200 ENOG4108IG5 Transcriptional regulator G7048_RS17215 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G7048_RS17220 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) G7048_RS17230 ENOG4105D1Q UPF0246 protein G7048_RS17235 ENOG4105C03 ribonuclease G7048_RS17245 ENOG4105EKQ RNA-directed DNA polymerase G7048_RS17250 ENOG4105EI2 Pseudouridine synthase G7048_RS17265 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G7048_RS17270 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G7048_RS17275 ENOG4108UHJ MAF-like protein G7048_RS17280 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein G7048_RS17285 ENOG4105VGS 50s ribosomal protein l32 G7048_RS17290 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) G7048_RS17295 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G7048_RS17300 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G7048_RS17305 ENOG4105CHR reductase G7048_RS17310 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G7048_RS17315 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G7048_RS17325 ENOG4105EMN RNA polymerase sigma factor G7048_RS17340 ENOG4105C0H protease G7048_RS17345 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) G7048_RS17350 ENOG4105C3F Signal peptidase i G7048_RS17360 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) G7048_RS17365 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G7048_RS17370 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) G7048_RS17375 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) G7048_RS17380 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) G7048_RS17385 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) G7048_RS17390 ENOG4105ETT transcriptional Regulator, LysR family G7048_RS17400 ENOG4105CQ0 ABC transporter G7048_RS17420 ENOG4108KXV response regulator G7048_RS17425 ENOG4105CRK lysyL-tRNA synthetase G7048_RS17430 ENOG4105C6Y Udp-glucose 6-dehydrogenase G7048_RS17440 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G7048_RS17455 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G7048_RS17460 ENOG4105D3Q Sugar transferase G7048_RS17475 ENOG4108VIA integral membrane protein G7048_RS17480 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) G7048_RS17485 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) G7048_RS17490 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G7048_RS17495 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase G7048_RS17500 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) G7048_RS17510 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G7048_RS17515 ENOG4105KWI UPF0339 protein G7048_RS17520 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G7048_RS17525 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G7048_RS17535 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G7048_RS17550 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G7048_RS17555 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G7048_RS17580 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G7048_RS17585 ENOG4105CFG Acts as a chaperone (By similarity) G7048_RS17590 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G7048_RS17595 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) G7048_RS17605 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G7048_RS17610 ENOG4105K9Q Binds to the 23S rRNA (By similarity) G7048_RS17615 ENOG4105CDU Replicative dna helicase G7048_RS17630 ENOG4108IAB Phoh family G7048_RS17635 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G7048_RS17645 ENOG4105CHM Aminotransferase G7048_RS17650 ENOG4105D6E homoserine dehydrogenase G7048_RS17660 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b G7048_RS17665 ENOG4105CVM Molybdenum cofactor synthesis domain protein G7048_RS17670 ENOG4105M00 molybdopterin converting factor, subunit 1 G7048_RS17700 ENOG4108ZAF Molybdopterin G7048_RS17710 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G7048_RS17720 ENOG4107RGH Aldehyde dehydrogenase G7048_RS17730 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) G7048_RS17735 ENOG4107RZC phospholipase d G7048_RS17765 ENOG4105X0D Fimbrial protein G7048_RS17775 ENOG4105JSC dimethylmenaquinone methyltransferase G7048_RS17780 ENOG4105C5I Dehydrogenase G7048_RS17790 ENOG4108MP6 LysR family Transcriptional regulator G7048_RS17800 ENOG4105E5Q amino acid AbC transporter G7048_RS17805 ENOG4105DRP amino acid AbC transporter G7048_RS17810 ENOG4105CDA abc transporter atp-binding protein G7048_RS17830 ENOG4107R7A Allophanate hydrolase subunit 2 G7048_RS17840 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit G7048_RS17845 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G7048_RS17930 ENOG4105EUV Phenol 2-monooxygenase G7048_RS17945 ENOG4108PVQ transcriptional regulator G7048_RS17960 ENOG4105CPW cytochrome b561 G7048_RS17965 ENOG4108YYC ycei family G7048_RS17995 ENOG4105ME7 Membrane G7048_RS18005 ENOG4105CSU acyl-Coa dehydrogenase G7048_RS18015 ENOG4105C6K Malic enzyme G7048_RS18020 ENOG4105C2W permease G7048_RS18025 ENOG4105ECQ AraC Family Transcriptional Regulator G7048_RS18035 ENOG4105F27 Major Facilitator G7048_RS18040 ENOG4105HEI LysR family (Transcriptional regulator G7048_RS18055 ENOG4105KHM amidohydrolase 2 G7048_RS18065 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G7048_RS18080 ENOG4107YCY Transcriptional regulator G7048_RS18085 ENOG4105VT2 5-hydroxyisourate hydrolase G7048_RS18105 ENOG4107QUY Guanine deaminase G7048_RS18110 ENOG4105DHP deoxycytidine triphosphate deaminase G7048_RS18115 ENOG4105CGZ zinc metallopeptidase G7048_RS18120 ENOG4105C1J atp-dependent rna helicase G7048_RS18125 ENOG41061CK Antibiotic biosynthesis monooxygenase G7048_RS18130 ENOG4108XG2 Histidine kinase G7048_RS18140 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) G7048_RS18150 ENOG4108EC8 DNA internalization-related competence protein ComEC G7048_RS18175 ENOG4105KHC sulfurtransferase G7048_RS18195 ENOG41086K9 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G7048_RS18200 ENOG4105CTB Polyprenyl synthetase G7048_RS18205 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) G7048_RS18210 ENOG4105CH5 extracellular solute-binding protein, family 7 G7048_RS18225 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G7048_RS18235 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) G7048_RS18240 ENOG4105E0C molybdate abc transporter G7048_RS18245 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein G7048_RS18250 ENOG4105F4R Transcriptional regulator mode G7048_RS18255 ENOG4105C0Z ABC transporter G7048_RS18260 ENOG4108IV0 ABC, transporter G7048_RS18275 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS18310 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G7048_RS18320 ENOG4105CND Glycosyl transferase, family 2 G7048_RS18325 ENOG4107XM9 (LipO)protein G7048_RS18330 ENOG4105K59 histidine triad (HIT) protein G7048_RS18345 ENOG4105KME endoribonuclease L-psp G7048_RS18360 ENOG4108Z9W Outer membrane porin G7048_RS18370 ENOG4105BZU Histidine kinase G7048_RS18375 ENOG4105C2C drug resistance transporter, Bcr CflA G7048_RS18380 ENOG4105C7W Xanthine dehydrogenase G7048_RS18395 ENOG4105C2J ABC transporter G7048_RS18400 ENOG4105UIB (ABC) transporter G7048_RS18420 ENOG4105CJP fad dependent oxidoreductase G7048_RS18425 ENOG4105CDA abc transporter atp-binding protein G7048_RS18430 ENOG4105E5Q amino acid AbC transporter G7048_RS18435 ENOG4106TNF Periplasmic binding protein G7048_RS18455 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G7048_RS18460 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) G7048_RS18475 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) G7048_RS18480 ENOG4105PI0 Ferredoxin G7048_RS18505 ENOG4107S7U Sulfide dehydrogenase G7048_RS18520 ENOG4105CE1 Ferrous iron transport protein b G7048_RS18530 ENOG4105DBV ornithine carbamoyltransferase G7048_RS18535 ENOG4105C8Y Acetylornithine aminotransferase G7048_RS18550 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) G7048_RS18555 ENOG4105CJR Integral membrane protein (MviN G7048_RS18560 ENOG41063JG Transcriptional regulator G7048_RS18565 ENOG4105CSR polyphosphate kinase 2 G7048_RS18570 ENOG4105SHT UspA domain-containing protein G7048_RS18580 ENOG4105CXB phosphoribosylaminoimidazole synthetase G7048_RS18585 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G7048_RS18595 ENOG4105DJ0 Poly(A) Polymerase G7048_RS18600 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G7048_RS18615 ENOG4108EX3 reductase G7048_RS18635 ENOG4105HEI LysR family (Transcriptional regulator G7048_RS18640 ENOG4108RYK Nad-dependent epimerase dehydratase G7048_RS18670 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS18675 ENOG4105ETT transcriptional Regulator, LysR family G7048_RS18690 ENOG4105MWK D-amino acid dehydrogenase, small subunit G7048_RS18710 ENOG4105E3W Two component transcriptional regulator (Winged helix family G7048_RS18715 ENOG4105EB3 Histidine kinase G7048_RS18720 ENOG4105GIJ Glycine betaine G7048_RS18725 ENOG4108HQS Glycine betaine G7048_RS18730 ENOG4108IJ7 Glycine betaine G7048_RS18740 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS18755 ENOG4108TEB UPF0114 protein G7048_RS18760 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G7048_RS18770 ENOG4105W2Z cytochrome C, class I G7048_RS18780 ENOG4105C01 Dihydroxy-acid dehydratase G7048_RS18795 ENOG4105EUB pirin domain protein G7048_RS18805 ENOG4108UWD Iron-storage protein G7048_RS18820 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) G7048_RS18830 ENOG4108QBV Monogalactosyldiacylglycerol synthase G7048_RS18840 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component G7048_RS18845 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G7048_RS18850 ENOG4105ETT transcriptional Regulator, LysR family G7048_RS18855 ENOG4105EAC phosphoserine phosphatase G7048_RS18870 ENOG4105BZS acriflavin resistance protein G7048_RS18895 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G7048_RS18900 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G7048_RS18905 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) G7048_RS18910 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G7048_RS18945 ENOG4108VKG metal-dependent hydrolase G7048_RS18950 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G7048_RS18980 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) G7048_RS19025 ENOG4105CDA abc transporter atp-binding protein G7048_RS19035 ENOG4105E5Q amino acid AbC transporter G7048_RS19060 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase G7048_RS19245 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G7048_RS19330 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G7048_RS19440 ENOG4105C6T cysteine synthase G7048_RS19445 ENOG4105E09 nadh pyrophosphatase G7048_RS19450 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) G7048_RS19455 ENOG4107SQD Transcriptional regulator, GntR family G7048_RS19460 ENOG4105T38 integral membrane protein G7048_RS19465 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G7048_RS19485 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G7048_RS19490 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS19495 ENOG4105ETT transcriptional Regulator, LysR family G7048_RS19510 ENOG4107RRE RNA-directed DNA polymerase G7048_RS19545 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G7048_RS19550 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) G7048_RS19555 ENOG4105EM2 membrane G7048_RS19565 ENOG4108UQY Iron-storage protein G7048_RS19570 ENOG4105D3R alkyl hydroperoxide reductase G7048_RS19575 ENOG4108JU3 Alkyl hydroperoxide reductase G7048_RS19590 ENOG4105EXG Transcriptional regulator G7048_RS19595 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) G7048_RS19600 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G7048_RS19610 ENOG4107QN1 sodium solute G7048_RS19630 ENOG410811B TRANSCRIPTIONal G7048_RS19640 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G7048_RS19645 ENOG4105RD8 TRAP dicarboxylate transporter G7048_RS19660 ENOG4108Z9W Outer membrane porin G7048_RS19680 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G7048_RS19685 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G7048_RS19690 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS19700 ENOG4105V9V Short-chain dehydrogenase reductase Sdr G7048_RS19710 ENOG4105ERH Fumarylacetoacetate hydrolase G7048_RS19725 ENOG4105C2C drug resistance transporter, Bcr CflA G7048_RS19730 ENOG4107RZC phospholipase d G7048_RS19735 ENOG4105DG4 malate L-lactate dehydrogenase G7048_RS19740 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G7048_RS19745 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family G7048_RS19760 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G7048_RS19790 ENOG4105K6B K06886 hemoglobin G7048_RS19795 ENOG4105ECY inositol monophosphatase G7048_RS19810 ENOG4105D7W serine acetyltransferase G7048_RS19825 ENOG4105C57 major facilitator superfamily G7048_RS19830 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase G7048_RS19835 ENOG4108RIR Molybdenum cofactor biosynthesis protein G7048_RS19845 ENOG4105CMS peptidase U62, modulator of DNA gyrase G7048_RS19855 ENOG4105XJC Two component transcriptional regulator (Winged helix family G7048_RS19860 ENOG4105D2X ABC transporter substrate-binding protein G7048_RS19870 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component G7048_RS19875 ENOG4106FTQ Taurine ABC transporter, periplasmic G7048_RS19880 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G7048_RS19900 ENOG4107S7U Sulfide dehydrogenase G7048_RS19925 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G7048_RS19930 ENOG4105EJC lysr family transcriptional regulator G7048_RS19950 ENOG4105VCC 30S ribosomal protein S21 G7048_RS19965 ENOG4105CBX hi0933 family G7048_RS19975 ENOG4108S4H thioesterase Superfamily protein G7048_RS19995 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G7048_RS20000 ENOG4108I0Q anthranilate phosphoribosyltransferase G7048_RS20010 ENOG4105BZU Histidine kinase G7048_RS20015 ENOG4108NVM synthesis repressor PhaR G7048_RS20020 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) G7048_RS20030 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) G7048_RS20040 ENOG4105C5Q Transcriptional regulator G7048_RS20045 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS20050 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G7048_RS20065 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) G7048_RS20075 ENOG4105K70 DNA-binding protein G7048_RS20080 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase G7048_RS20085 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G7048_RS20095 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G7048_RS20105 ENOG4107EJG GntR family transcriptional regulator G7048_RS20115 ENOG4107S1Q Phosphatase G7048_RS20185 ENOG41081J6 Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) G7048_RS20225 ENOG4105DPX Hydrogenase, large subunit G7048_RS20235 ENOG4108MGI Transcriptional regulator G7048_RS20245 ENOG4108IV0 ABC, transporter G7048_RS20250 ENOG4105C0Z ABC transporter G7048_RS20255 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G7048_RS20260 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS20280 ENOG4105C1J atp-dependent rna helicase G7048_RS20285 ENOG4105C5H ABC transporter G7048_RS20300 ENOG4105KXX peptidase s58 dmpa G7048_RS20315 ENOG4105D01 (LipO)protein G7048_RS20335 ENOG4107R16 Multicopper oxidase G7048_RS20390 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G7048_RS20395 ENOG4105MWK D-amino acid dehydrogenase, small subunit G7048_RS20400 ENOG4105CE9 30S ribosomal protein S2 G7048_RS20405 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) G7048_RS20410 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) G7048_RS20415 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) G7048_RS20420 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G7048_RS20425 ENOG4105KNE Phosphatidate cytidylyltransferase G7048_RS20430 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) G7048_RS20435 ENOG4105DZP Membrane-associated zinc metalloprotease G7048_RS20440 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G7048_RS20450 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G7048_RS20455 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) G7048_RS20460 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G7048_RS20465 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G7048_RS20470 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G7048_RS20475 ENOG4108RWN rrna methyltransferase G7048_RS20480 ENOG4105C0R drug resistance transporter emrb qaca subfamily G7048_RS20485 ENOG4105CW7 secretion protein, HlyD family G7048_RS20490 ENOG4105ETP RND efflux system, outer membrane lipoprotein G7048_RS20510 ENOG4105VEJ Heat shock protein G7048_RS20530 ENOG4108IAJ Nad-dependent epimerase dehydratase G7048_RS20535 ENOG4105DHQ Histidine kinase G7048_RS20585 ENOG4105W2Z cytochrome C, class I G7048_RS20590 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G7048_RS20595 ENOG4105W2Z cytochrome C, class I G7048_RS20620 ENOG4105CGH 5'-nucleotidase G7048_RS20625 ENOG4105CUC YeeE YedE family protein G7048_RS20630 ENOG4106BE1 Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers (By similarity) G7048_RS20640 ENOG4108V62 Rhodanese domain protein G7048_RS20685 ENOG4105CYM Glutathione S-transferase G7048_RS20690 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) G7048_RS20695 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) G7048_RS20700 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant G7048_RS20715 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G7048_RS20720 ENOG4108R6G acetyltransferase G7048_RS20730 ENOG4108IJ8 ABC transporter G7048_RS20740 ENOG4105BZN citrate synthase G7048_RS20745 ENOG410846T CoA-transferase family III G7048_RS20750 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase G7048_RS20755 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G7048_RS20760 ENOG4107T31 5'-nucleotidase G7048_RS20770 ENOG4105CHU acetyl-coa acetyltransferase G7048_RS20795 ENOG4105WH1 Two component transcriptional regulator luxr family G7048_RS20805 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) G7048_RS20810 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G7048_RS20815 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division G7048_RS20835 ENOG4105C26 Dehydrogenase G7048_RS20840 ENOG4108JPW Aminotransferase G7048_RS20850 ENOG4108ZUW Major pilin subunit G7048_RS20880 ENOG4105DJ2 Major Facilitator Superfamily G7048_RS20905 ENOG4105HSS phospholipase C G7048_RS20925 ENOG4105CHR reductase G7048_RS20950 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G7048_RS20960 ENOG4105C0R drug resistance transporter emrb qaca subfamily G7048_RS20965 ENOG4107QWB Ornithine cyclodeaminase G7048_RS20970 ENOG4105EW9 transcriptional regulator AsnC family G7048_RS20975 ENOG4105BZU Histidine kinase G7048_RS20995 ENOG4105BZM domain protein G7048_RS21015 ENOG4105IKQ hydratase G7048_RS21025 ENOG4108HPG -acetyltransferase G7048_RS21035 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) G7048_RS21040 ENOG4105HHA aminodeoxychorismate lyase G7048_RS21045 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) G7048_RS21050 ENOG4107QRG dna polymerase iii G7048_RS21060 ENOG4105F8V Hydrolase, tatD family G7048_RS21070 ENOG4105BZ1 (ABC) transporter G7048_RS21075 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) G7048_RS21080 ENOG4105KCK Peptidoglycan-associated lipoprotein G7048_RS21090 ENOG4105CUZ uba thif-type nad fad binding protein G7048_RS21100 ENOG4107EF8 Glycosyl transferase (Group 1 G7048_RS21105 ENOG4105EY8 ABC transporter G7048_RS21120 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G7048_RS21130 ENOG4105C5I Dehydrogenase G7048_RS21140 ENOG4105KVH Transcriptional regulator G7048_RS21145 ENOG4105CS1 NAD(P)H quinone oxidoreductase G7048_RS21160 ENOG4105ES5 Histidine kinase G7048_RS21165 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G7048_RS21170 ENOG4105DXI Major Facilitator superfamily G7048_RS21190 ENOG4105CQ7 ATP-dependent helicase G7048_RS21195 ENOG4105CY0 Metallo-Beta-Lactamase G7048_RS21210 ENOG4105HEI LysR family (Transcriptional regulator G7048_RS21215 ENOG4105CV8 reductase G7048_RS21240 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G7048_RS21245 ENOG4105HDK L-asparaginase G7048_RS21250 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G7048_RS21255 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) G7048_RS21260 ENOG4105W49 UPF0434 protein G7048_RS21265 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) G7048_RS21270 ENOG4108ZZF transport protein (ExbD) G7048_RS21280 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G7048_RS21285 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G7048_RS21295 ENOG410642W LysR family Transcriptional regulator G7048_RS21305 ENOG4105E9K Isocitrate dehydrogenase G7048_RS21355 ENOG4105WD1 Membrane G7048_RS21360 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G7048_RS21365 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G7048_RS21370 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G7048_RS21380 ENOG4108ETH Formylglycinamide ribotide synthetase G7048_RS21385 ENOG4105CKW Inner membrane protein yedI G7048_RS21400 ENOG4108IV0 ABC, transporter G7048_RS21405 ENOG4105C0Z ABC transporter G7048_RS21410 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G7048_RS21415 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS21455 ENOG4105CFP Peptidase U32 G7048_RS21470 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) G7048_RS21490 ENOG41065RQ ADP-ribosylation crystallin J1 G7048_RS21500 ENOG4108Z6B deaminase G7048_RS21505 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A G7048_RS21515 ENOG410810E transcriptional regulator, lysR family G7048_RS21535 ENOG4105CDY transcriptional regulatory protein G7048_RS21560 ENOG4105EUB pirin domain protein G7048_RS21565 ENOG4105C72 UPF0176 protein G7048_RS21570 ENOG4105CHH sulfate transporter G7048_RS21575 ENOG4105K3G Periplasmic Protein G7048_RS21580 ENOG4105C28 cystathionine G7048_RS21585 ENOG4108UJV acyl-CoA thioesterase i G7048_RS21590 ENOG4108I0Y (ABC) transporter G7048_RS21595 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) G7048_RS21610 ENOG4105C2N RNA methyltransferase TrmH family group 3 G7048_RS21615 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G7048_RS21690 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein G7048_RS21695 ENOG41090JD Blue (Type 1) copper domain protein G7048_RS21705 ENOG4105CCT upf0313 protein G7048_RS21720 ENOG4105VEQ Cold shock protein G7048_RS21725 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G7048_RS21730 ENOG4105CGF Aromatic amino acid aminotransferase G7048_RS21740 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family G7048_RS21745 ENOG4105C3J Cysteine desulfurase G7048_RS21750 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins G7048_RS21755 ENOG4108Z4V iron-sulfur cluster assembly G7048_RS21760 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) G7048_RS21765 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB G7048_RS21770 ENOG4108ZIT Ferredoxin, 2FE-2S G7048_RS21775 ENOG4107RZZ dna polymerase iii epsilon subunit G7048_RS21795 ENOG4105D7T ABC transporter G7048_RS21800 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component G7048_RS21810 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G7048_RS21830 ENOG4108QIU Dehydrogenase G7048_RS21835 ENOG4105E39 Enoyl-CoA hydratase G7048_RS21840 ENOG4105K6S Short-chain dehydrogenase reductase Sdr G7048_RS21850 ENOG4108RK3 acyl-Coa dehydrogenase G7048_RS21865 ENOG4105X7H acyl-CoA dehydrogenase G7048_RS21880 ENOG4105CC9 acyl-Coa dehydrogenase G7048_RS21885 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS21890 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS21895 ENOG4105D25 secreted protein G7048_RS21910 ENOG4105E3W Two component transcriptional regulator (Winged helix family G7048_RS21915 ENOG4105EB3 Histidine kinase G7048_RS21920 ENOG4105C1P efflux transporter, rnd family, mfp subunit G7048_RS21925 ENOG4105BZS acriflavin resistance protein G7048_RS21930 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G7048_RS21955 ENOG4105QUC reductase G7048_RS21970 ENOG4105CIA precorrin-4 C(11)-methyltransferase G7048_RS21985 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G7048_RS21995 ENOG41069M3 Transcriptional regulator G7048_RS22020 ENOG4105C26 Dehydrogenase G7048_RS22030 ENOG41061H0 Monooxygenase G7048_RS22035 ENOG4107F9Y LysR family transcriptional regulator G7048_RS22045 ENOG4105D2S major facilitator superfamily G7048_RS22105 ENOG4105ENT Efflux transporter rnd family, mfp subunit G7048_RS22110 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G7048_RS22115 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G7048_RS22150 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS22165 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS22170 ENOG4105CHU acetyl-coa acetyltransferase G7048_RS22185 ENOG4107QPD alcohol dehydrogenase G7048_RS22190 ENOG4107VAM peptidase, m28 G7048_RS22210 ENOG4108UKI Enoyl-CoA hydratase G7048_RS22220 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G7048_RS22225 ENOG4105D5U fad dependent oxidoreductase G7048_RS22245 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) G7048_RS22250 ENOG4105E66 phosphoriboisomerase A G7048_RS22260 ENOG4105DGW oligopeptidase A G7048_RS22265 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G7048_RS22270 ENOG4108ZXC Two component transcriptional regulator, luxr family G7048_RS22275 ENOG4105BZU Histidine kinase G7048_RS22280 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G7048_RS22285 ENOG4107QSN dihydrolipoamide acetyltransferase G7048_RS22290 ENOG4107QN2 dihydrolipoyl dehydrogenase G7048_RS22310 ENOG4105CVE Lytic murein transglycosylase G7048_RS22315 ENOG4105CJB Exodeoxyribonuclease I G7048_RS22320 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G7048_RS22325 ENOG4105DSF transport protein G7048_RS22330 ENOG4108YYQ gCN5-related N-acetyltransferase G7048_RS22335 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) G7048_RS22345 ENOG4105CYM Glutathione S-transferase G7048_RS22355 ENOG4105ETT transcriptional Regulator, LysR family G7048_RS22360 ENOG4105D7A ATP-binding protein G7048_RS22365 ENOG4105CDY transcriptional regulatory protein G7048_RS22370 ENOG4105C12 Phosphoribosylglycinamide synthetase G7048_RS22375 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) G7048_RS22380 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G7048_RS22385 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) G7048_RS22390 ENOG4108Z03 MAF-like protein G7048_RS22400 ENOG4105FAE von Willebrand factor, type A G7048_RS22405 ENOG4105GMT ATPase associated with various cellular activities aaa_5 G7048_RS22415 ENOG4108VKQ nitriC oxide reductase G7048_RS22435 ENOG4105C4X radical SAM domain protein G7048_RS22440 ENOG4108UMR transcriptional regulator AsnC family G7048_RS22450 ENOG4108UMR transcriptional regulator AsnC family G7048_RS22465 ENOG4105F64 nitrite reductase G7048_RS22470 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G7048_RS22475 ENOG4105C03 ribonuclease G7048_RS22485 ENOG4107T9Q phosphonate abc transporter G7048_RS22490 ENOG4105D5T phosphonate abc transporter G7048_RS22505 ENOG4108KAZ Involved in phosphonate degradation (By similarity) G7048_RS22515 ENOG4105CHM Aminotransferase G7048_RS22520 ENOG4107R11 Transcriptional regulator G7048_RS22540 ENOG4105CJ2 (LipO)protein G7048_RS22545 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G7048_RS22565 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G7048_RS22585 ENOG4105C5I Dehydrogenase G7048_RS22635 ENOG4105DH7 May be involved in recombination (By similarity) G7048_RS22650 ENOG4108PNI recT protein G7048_RS22710 ENOG4106FAK Endodeoxyribonuclease RusA G7048_RS22740 ENOG4105DFP Integrase G7048_RS22775 ENOG4105CXN decarboxylase G7048_RS22790 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS22795 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G7048_RS22800 ENOG4107258 Transcriptional regulator G7048_RS22805 ENOG4105C1J atp-dependent rna helicase G7048_RS22830 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G7048_RS22835 ENOG4105E43 Extracellular solute-binding protein, family 5 G7048_RS22840 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component G7048_RS22850 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component G7048_RS22855 ENOG4108JQ5 ABC transporter G7048_RS22860 ENOG4105EBM Alpha Beta Hydrolase Fold protein G7048_RS22870 ENOG4105F04 LysR family Transcriptional regulator G7048_RS22890 ENOG4105IPI Membrane G7048_RS22895 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G7048_RS22900 ENOG4105C7S Dehydrogenase G7048_RS22905 ENOG4107QN2 dihydrolipoyl dehydrogenase G7048_RS22910 ENOG4105D6Z AFG1 family ATPase G7048_RS22925 ENOG4105DVT helicase G7048_RS22935 ENOG4105C0B DNA polymerase III (alpha subunit) G7048_RS22940 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) G7048_RS22945 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G7048_RS22965 ENOG4105C0B DNA polymerase III (alpha subunit) G7048_RS22990 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS22995 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G7048_RS23005 ENOG4105CPT Alpha beta hydrolase G7048_RS23010 ENOG4105ETT transcriptional Regulator, LysR family G7048_RS23045 ENOG4105WH1 Two component transcriptional regulator luxr family G7048_RS23050 ENOG4105ENE Histidine kinase G7048_RS23060 ENOG41066T0 asmA family G7048_RS23070 ENOG4105D3G Pseudouridine synthase G7048_RS23145 ENOG4107R3N Filamentation induced by cAMP protein fic G7048_RS23155 ENOG4105C26 Dehydrogenase G7048_RS23160 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G7048_RS23180 ENOG4105HMI Membrane G7048_RS23185 ENOG4105DUM transcriptional regulator, lysR family G7048_RS23200 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria G7048_RS23205 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G7048_RS23210 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) G7048_RS23215 ENOG4105EWK phytoene G7048_RS23220 ENOG4105EQ1 Transcriptional regulator G7048_RS23235 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate G7048_RS23240 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) G7048_RS23250 ENOG41090ED Protein with unknown function (DUF469) G7048_RS23280 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G7048_RS23295 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS23305 ENOG4105C26 Dehydrogenase G7048_RS23310 ENOG4106NZI LysR family Transcriptional regulator G7048_RS23315 ENOG4105C85 amino acid G7048_RS23320 ENOG410839S Toxic component of a toxin-antitoxin (TA) module (By similarity) G7048_RS23330 ENOG4105C0R drug resistance transporter emrb qaca subfamily G7048_RS23335 ENOG4105BZ1 (ABC) transporter G7048_RS23345 ENOG4105BZU Histidine kinase G7048_RS23350 ENOG4105KK4 UPF0060 membrane protein G7048_RS23355 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G7048_RS23365 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G7048_RS23370 ENOG4108JQC penicillin-binding protein 1A G7048_RS23380 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase G7048_RS23390 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G7048_RS23400 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class G7048_RS23405 ENOG4105CHU acetyl-coa acetyltransferase G7048_RS23410 ENOG4105CHR reductase G7048_RS23415 ENOG4105C5H ABC transporter G7048_RS23425 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) G7048_RS23430 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G7048_RS23435 ENOG4105CZX twitching motility protein G7048_RS23440 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) G7048_RS23450 ENOG4108R3D Electron transport complex G7048_RS23465 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G7048_RS23475 ENOG4108IQE Amp-dependent synthetase and ligase G7048_RS23480 ENOG4105DRR Transcriptional regulator, GntR family G7048_RS23490 ENOG4105DJT lAO AO transport system ATPase G7048_RS23495 ENOG4107QX3 carboxylase G7048_RS23515 ENOG4105EQ2 LysR family Transcriptional regulator G7048_RS23535 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS23540 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G7048_RS23545 ENOG4105HF0 Membrane G7048_RS23565 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) G7048_RS23580 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G7048_RS23585 ENOG410830R acetyltransferase G7048_RS23635 ENOG4107RP9 extracellular solute-binding protein, family 3 G7048_RS23655 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G7048_RS23680 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 G7048_RS23705 ENOG4105C0D helicase G7048_RS23755 ENOG4107U53 septum site-determining protein minD G7048_RS23770 ENOG4108594 Permease of the drug metabolite transporter G7048_RS23790 ENOG4105CHR reductase G7048_RS23795 ENOG4108UYE Lactoylglutathione lyase G7048_RS23800 ENOG4108UHU Aldolase G7048_RS23805 ENOG4105C01 Dihydroxy-acid dehydratase G7048_RS23810 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G7048_RS23815 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G7048_RS23820 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter G7048_RS23825 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G7048_RS23830 ENOG4105ETE Transcriptional regulator (LacI family G7048_RS23860 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G7048_RS23865 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) G7048_RS23880 ENOG4105UGU tonB-dependent Receptor G7048_RS23890 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G7048_RS23895 ENOG4108R86 Transcriptional regulator G7048_RS23900 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G7048_RS23910 ENOG4105DFG type I secretion outer membrane protein G7048_RS23915 ENOG4105CD5 CoA-binding domain protein G7048_RS23920 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase G7048_RS23925 ENOG4107QKV phosphomannomutase G7048_RS23930 ENOG4105D03 DNA-3-methyladenine glycosylase II G7048_RS23945 ENOG4105BZU Histidine kinase G7048_RS23950 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G7048_RS23965 ENOG4105D8V Glucose sorbosone dehydrogenase G7048_RS23970 ENOG4105K4H Nlp p60 protein G7048_RS24000 ENOG4105C26 Dehydrogenase G7048_RS24005 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G7048_RS24035 ENOG4108K0D peptidase, M48 G7048_RS24045 ENOG4108K0D peptidase, M48 G7048_RS24070 ENOG4105CEP NADH dehydrogenase G7048_RS24090 ENOG4105DIJ Phosphoethanolamine transferase G7048_RS24100 ENOG4105XJC Two component transcriptional regulator (Winged helix family G7048_RS24105 ENOG4105DHQ Histidine kinase G7048_RS24115 ENOG4105EFZ amidohydrolase G7048_RS24120 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase G7048_RS24130 ENOG4105C7J ABC transporter, permease G7048_RS24135 ENOG4108JJB ABC transporter G7048_RS24140 ENOG4108IQI permease G7048_RS24145 ENOG4105EW9 transcriptional regulator AsnC family G7048_RS24150 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G7048_RS24160 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G7048_RS24165 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G7048_RS24170 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) G7048_RS24175 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor G7048_RS24180 ENOG4105D3G Pseudouridine synthase G7048_RS24185 ENOG4105CP9 extracellular ligand-binding receptor G7048_RS24190 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS24195 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G7048_RS24200 ENOG4105C0Z ABC transporter G7048_RS24205 ENOG4108IV0 ABC, transporter G7048_RS24210 ENOG410904N short-chain dehydrogenase reductase G7048_RS24215 ENOG4105CHU acetyl-coa acetyltransferase G7048_RS24225 ENOG4105W3S hemerythrin-like, metal-binding protein G7048_RS24230 ENOG41081QV Universal stress protein G7048_RS24290 ENOG4105WH1 Two component transcriptional regulator luxr family G7048_RS24320 ENOG4105GR3 Histidine kinase G7048_RS24355 ENOG4107ZQV short-chain dehydrogenase reductase G7048_RS24395 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G7048_RS24415 ENOG4105EQ2 LysR family Transcriptional regulator G7048_RS24425 ENOG4106PGW Short-chain dehydrogenase reductase Sdr G7048_RS24430 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme G7048_RS24450 ENOG4105ETE Transcriptional regulator (LacI family G7048_RS24490 ENOG4105EG2 ABC transporter, permease G7048_RS24520 ENOG41090R7 Ferric uptake G7048_RS24525 ENOG4108ESX Receptor G7048_RS24530 ENOG4107E2E PKHD-type hydroxylase G7048_RS24540 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G7048_RS24555 ENOG4105CHR reductase G7048_RS24560 ENOG4105V9V Short-chain dehydrogenase reductase Sdr G7048_RS24565 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS24585 ENOG4108KC1 acyl-Coa dehydrogenase G7048_RS24605 ENOG4107RGH Aldehyde dehydrogenase G7048_RS24610 ENOG4105F27 Major Facilitator G7048_RS24635 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G7048_RS24640 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) G7048_RS24650 ENOG4105CHU acetyl-coa acetyltransferase G7048_RS24660 ENOG4105CHR reductase G7048_RS24670 ENOG4105D2B acyl-CoA dehydrogenase G7048_RS24675 ENOG4105D2B acyl-CoA dehydrogenase G7048_RS24680 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G7048_RS24690 ENOG4105F2C Acetyl-CoA acetyltransferase G7048_RS24695 ENOG4108KC2 acyl-Coa dehydrogenase G7048_RS24700 ENOG4105CC9 acyl-Coa dehydrogenase G7048_RS24710 ENOG4105EA8 2-Nitropropane dioxygenase G7048_RS24730 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase G7048_RS24745 ENOG4105KUS lysozyme G7048_RS24850 ENOG4105EXC Acyl-transferase G7048_RS24855 ENOG4108EKC n-acetylglutamate synthase G7048_RS24870 ENOG4105BZU Histidine kinase G7048_RS24875 ENOG4105M4H endoribonuclease L-psp G7048_RS24880 ENOG4105MWK D-amino acid dehydrogenase, small subunit G7048_RS24895 ENOG4105CUG Oligopeptidase b G7048_RS24905 ENOG4105CNM Receptor G7048_RS24920 ENOG4108S3W Anti-feci sigma factor, fecr G7048_RS24925 ENOG4108SF5 RNA Polymerase G7048_RS24930 ENOG4105E0K tonB-dependent siderophore receptor G7048_RS24935 ENOG4108S3W Anti-feci sigma factor, fecr G7048_RS24945 ENOG4108SF5 RNA Polymerase G7048_RS24950 ENOG4108S3W Anti-feci sigma factor, fecr G7048_RS24955 ENOG4105CNM Receptor G7048_RS24985 ENOG4105JSC dimethylmenaquinone methyltransferase G7048_RS24990 ENOG4108JQ1 Dehydrogenase G7048_RS25000 ENOG4105C7F AcnD-accessory protein PrpF G7048_RS25005 ENOG4108I0Z Aconitate hydratase G7048_RS25010 ENOG4105BZN citrate synthase G7048_RS25020 ENOG4105CFF transcriptional regulator G7048_RS25035 ENOG4107E2E PKHD-type hydroxylase G7048_RS25040 ENOG4105J5J Outer membrane porin G7048_RS25050 ENOG4105E0A ABC, transporter G7048_RS25055 ENOG4105EHG Permease protein G7048_RS25060 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) G7048_RS25080 ENOG4108IPW abc transporter atp-binding protein G7048_RS25110 ENOG4105GAV receptor G7048_RS25125 ENOG4105D7N magnesium and cobalt transport protein CorA G7048_RS25135 ENOG4108Z4X TRANSCRIPTIONal G7048_RS25160 ENOG4108IV0 ABC, transporter G7048_RS25165 ENOG4105C0Z ABC transporter G7048_RS25175 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS25185 ENOG4108M0I Transcriptional regulator G7048_RS25215 ENOG4105C26 Dehydrogenase G7048_RS25245 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) G7048_RS25260 ENOG4105EHG Permease protein G7048_RS25265 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) G7048_RS25280 ENOG4107SQD Transcriptional regulator, GntR family G7048_RS25300 ENOG4105CAU Arsenical resistance protein, ArsH G7048_RS25305 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase G7048_RS25325 ENOG4107XZA Glycosyl transferase family 2 G7048_RS25345 ENOG4107EJG GntR family transcriptional regulator G7048_RS25365 ENOG4108UYE Lactoylglutathione lyase G7048_RS25390 ENOG4105C5I Dehydrogenase G7048_RS25405 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G7048_RS25430 ENOG4108Z9W Outer membrane porin G7048_RS25440 ENOG4105C7J ABC transporter, permease G7048_RS25455 ENOG4105DRR Transcriptional regulator, GntR family G7048_RS25460 ENOG4105C7B Threonine dehydratase G7048_RS25465 ENOG4105DDW LysR family Transcriptional regulator G7048_RS25470 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein G7048_RS25520 ENOG4105C26 Dehydrogenase G7048_RS25525 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein G7048_RS25550 ENOG4105D25 secreted protein G7048_RS25585 ENOG4105GAK amidohydrolase 2 G7048_RS25590 ENOG4105KHM amidohydrolase 2 G7048_RS25595 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase G7048_RS25605 ENOG4108Z9W Outer membrane porin G7048_RS25615 ENOG4105DDW LysR family Transcriptional regulator G7048_RS25625 ENOG4107XC4 flavin reductase domain protein, FMN-binding G7048_RS25635 ENOG4105C0A alcohol dehydrogenase G7048_RS25655 ENOG4105DXM phenylacetic acid degradation protein G7048_RS25660 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS25665 ENOG4105CHR reductase G7048_RS25685 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS25695 ENOG4105E39 Enoyl-CoA hydratase G7048_RS25705 ENOG4108Z9W Outer membrane porin G7048_RS25710 ENOG4105EGI Transcriptional regulator G7048_RS25760 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS25765 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS25770 ENOG4108T2C cysteine dioxygenase type I G7048_RS25785 ENOG4105CYM Glutathione S-transferase G7048_RS25795 ENOG4105DUM transcriptional regulator, lysR family G7048_RS25800 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS25845 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G7048_RS25850 ENOG4105ETT transcriptional Regulator, LysR family G7048_RS25855 ENOG4105F0I Aminotransferase G7048_RS25870 ENOG4108TGY Glutathione S-transferase G7048_RS25905 ENOG4107RM6 sulfurtransferase G7048_RS25935 ENOG4108FUF Transcriptional regulator, IclR family G7048_RS25950 ENOG4105FA0 parb-like partition protein G7048_RS25955 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G7048_RS25995 ENOG4105IKQ hydratase G7048_RS26005 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G7048_RS26035 ENOG4105ERH Fumarylacetoacetate hydrolase G7048_RS26050 ENOG4105MSY salicylate hydroxylase G7048_RS26060 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G7048_RS26065 ENOG4105MKU Transcriptional regulator G7048_RS26075 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS26090 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS26095 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G7048_RS26100 ENOG4105FP9 thiamine pyrophosphate G7048_RS26110 ENOG4108Z9W Outer membrane porin G7048_RS26115 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G7048_RS26140 ENOG4105D25 secreted protein G7048_RS26150 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G7048_RS26155 ENOG4105CYC Transferase G7048_RS26180 ENOG4105X7H acyl-CoA dehydrogenase G7048_RS26185 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS26190 ENOG4105CI0 Citrate lyase G7048_RS26195 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS26200 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme G7048_RS26240 ENOG4107RUY (E1 component), alpha subunit G7048_RS26245 ENOG4105CPP Dehydrogenase, E1 component G7048_RS26250 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein G7048_RS26255 ENOG4107QSN dihydrolipoamide acetyltransferase G7048_RS26315 ENOG4108UKI Enoyl-CoA hydratase G7048_RS26320 ENOG4105CHR reductase G7048_RS26345 ENOG4105E39 Enoyl-CoA hydratase G7048_RS26350 ENOG4105E39 Enoyl-CoA hydratase G7048_RS26355 ENOG4108IXY short-chain dehydrogenase reductase G7048_RS26360 ENOG41082JN Transcriptional regulator G7048_RS26380 ENOG4105CCU oxidase (Subunit III) G7048_RS26390 ENOG4108IPT Naphthoate synthase G7048_RS26400 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G7048_RS26405 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G7048_RS26420 ENOG4105E3J oxidoreductase G7048_RS26450 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G7048_RS26475 ENOG4105EWK phytoene G7048_RS26485 ENOG4105BZJ Electron transfer flavoprotein G7048_RS26490 ENOG4105C10 Electron transfer flavoprotein G7048_RS26510 ENOG4105CSH Transporter G7048_RS26515 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G7048_RS26520 ENOG4105SKE transcriptional Regulator LysR family G7048_RS26525 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G7048_RS26535 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) G7048_RS26555 ENOG4107RSM transcriptional regulator G7048_RS26565 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G7048_RS26595 ENOG4105DJB Major Facilitator Superfamily G7048_RS26625 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS26630 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G7048_RS26635 ENOG4105C0Z ABC transporter G7048_RS26640 ENOG4108IV0 ABC, transporter G7048_RS26655 ENOG4105E5G Alpha beta hydrolase fold G7048_RS26660 ENOG4105FDP GntR family transcriptional regulator G7048_RS26665 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G7048_RS26705 ENOG4105CSH Transporter G7048_RS26710 ENOG4105ES4 Nitrilase G7048_RS26715 ENOG4107RT4 flavin reductase domain protein G7048_RS26720 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G7048_RS26725 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G7048_RS26730 ENOG4105C7K acetolactate synthase G7048_RS26745 ENOG4105CQB FAD linked oxidase domain protein G7048_RS26755 ENOG4105JSC dimethylmenaquinone methyltransferase G7048_RS26775 ENOG4105C6F GntR Family Transcriptional Regulator G7048_RS26780 ENOG4105C5I Dehydrogenase G7048_RS26785 ENOG4105CXK mandelate racemase muconate lactonizing G7048_RS26800 ENOG4108IG5 Transcriptional regulator G7048_RS26820 ENOG4108IQE Amp-dependent synthetase and ligase G7048_RS26825 ENOG4105C0Z ABC transporter G7048_RS26830 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS26845 ENOG4108IV0 ABC, transporter G7048_RS26850 ENOG4108RZE Tetr family transcriptional regulator G7048_RS26860 ENOG4105E39 Enoyl-CoA hydratase G7048_RS26875 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G7048_RS26905 ENOG4105C26 Dehydrogenase G7048_RS26925 ENOG4108ZX5 transcriptional regulator G7048_RS26935 ENOG4105CSU acyl-Coa dehydrogenase G7048_RS26945 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G7048_RS26970 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS26975 ENOG4105DFS Conserved Protein G7048_RS26980 ENOG4108Z9W Outer membrane porin G7048_RS26990 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme G7048_RS26995 ENOG4105CHR reductase G7048_RS27015 ENOG4108ZX5 transcriptional regulator G7048_RS27080 ENOG4107S1Q Phosphatase G7048_RS27100 ENOG4105YB8 TM2 domain containing protein G7048_RS27115 ENOG4105ETT transcriptional Regulator, LysR family G7048_RS27120 ENOG4105BZC d-serine deaminase G7048_RS27135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G7048_RS27140 ENOG4108JQ6 ABC transporter G7048_RS27150 ENOG4105CBN LysR family transcriptional regulator G7048_RS27175 ENOG4107QNJ CoA-transferase subunit B G7048_RS27180 ENOG4107QX3 carboxylase G7048_RS27185 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G7048_RS27200 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G7048_RS27215 ENOG4108XEP Alpha Beta Hydrolase Fold protein G7048_RS27225 ENOG4108IV0 ABC, transporter G7048_RS27230 ENOG4105C0Z ABC transporter G7048_RS27240 ENOG4105C32 Amino acid ABC transporter (Permease) G7048_RS27250 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G7048_RS27255 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G7048_RS27280 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase G7048_RS27365 ENOG4105CHR reductase G7048_RS27375 ENOG4105CHU acetyl-coa acetyltransferase G7048_RS27390 ENOG410846T CoA-transferase family III G7048_RS27395 ENOG4105C1G acyl-Coa dehydrogenase G7048_RS27400 ENOG4105CEY Amp-dependent synthetase and ligase G7048_RS27435 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G7048_RS27480 ENOG4105DMF Dehydrogenase G7048_RS27485 ENOG4105CTX dehydratase G7048_RS27495 ENOG4105EQX glucarate dehydratase G7048_RS27500 ENOG4105DRR Transcriptional regulator, GntR family G7048_RS27505 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase G7048_RS27515 ENOG4105C5I Dehydrogenase G7048_RS27530 ENOG4105C26 Dehydrogenase G7048_RS27545 ENOG4105DIA mandelate racemase muconate lactonizing G7048_RS27550 ENOG41073TP transcriptional regulator G7048_RS27555 ENOG4105DIA mandelate racemase muconate lactonizing G7048_RS27575 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding G7048_RS27590 ENOG4105CNN ABC, transporter G7048_RS27595 ENOG4105C2J ABC transporter G7048_RS27600 ENOG4108SV3 Tmao reductase system periplasmic protein tort G7048_RS27615 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G7048_RS27620 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein G7048_RS27630 ENOG4105DUM transcriptional regulator, lysR family G7048_RS27650 ENOG4108MZY G7048_RS27655 ENOG4108MR5 G7048_RS27660 ENOG4105DKK Benzoate G7048_RS27670 ENOG4105D2S major facilitator superfamily G7048_RS27695 ENOG410626B catechol 1,2-dioxygenase G7048_RS27710 ENOG4105BZU Histidine kinase G7048_RS27740 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G7048_RS27750 ENOG4105E2X shikimate dehydrogenase G7048_RS27755 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G7048_RS27760 ENOG4105CSH Transporter G7048_RS27765 ENOG4108TFY Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G7048_RS27780 ENOG4105EJC lysr family transcriptional regulator G7048_RS27785 ENOG4108VVQ metallophosphoesterase G7048_RS27800 ENOG4105JAB phenazine biosynthesis protein, phzf family G7048_RS27810 ENOG4105E39 Enoyl-CoA hydratase G7048_RS27830 ENOG4105DRP amino acid AbC transporter G7048_RS27835 ENOG4108Q1T ABC transporter G7048_RS27870 ENOG4105CQ2 DNA polymerase G7048_RS27875 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G7048_RS27880 ENOG4105CVM Molybdenum cofactor synthesis domain protein G7048_RS27885 ENOG4105CVM Molybdenum cofactor synthesis domain protein G7048_RS27905 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G7048_RS27935 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G7048_RS27940 ENOG4105QAX Iron-sulfur G7048_RS27960 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G7048_RS27990 ENOG4105CA0 peroxidase G7048_RS28010 ENOG4106NZI LysR family Transcriptional regulator G7048_RS28030 ENOG4108SF5 RNA Polymerase G7048_RS28060 ENOG4105EXW epimerase dehydratase G7048_RS28075 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) G7048_RS28085 ENOG41061H0 Monooxygenase G7048_RS28115 ENOG4105D25 secreted protein G7048_RS28135 ENOG4105EYM Major Facilitator superfamily G7048_RS28140 ENOG4105E0K tonB-dependent siderophore receptor G7048_RS28175 ENOG4105D7T ABC transporter G7048_RS28195 ENOG4105BZU Histidine kinase G7048_RS28250 ENOG4105DHQ Histidine kinase