locus-tag	class	description
G7048_RS00045	COG0251	oxidation-reduction process
G7048_RS00065	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G7048_RS00070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G7048_RS00075	COG4208	sulfate ABC transporter
G7048_RS00080	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G7048_RS00085	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G7048_RS00095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G7048_RS00100	COG0513	Belongs to the DEAD box helicase family
G7048_RS00105	COG1346	cytolysis
G7048_RS00115	COG1122	ATPase activity
G7048_RS00125	COG1268	BioY protein
G7048_RS00130	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS00135	COG0183	Belongs to the thiolase family
G7048_RS00150	COG1464	Belongs to the NlpA lipoprotein family
G7048_RS00170	COG2011	ABC-type metal ion transport system permease component
G7048_RS00175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G7048_RS00190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G7048_RS00195	COG0583	DNA-binding transcription factor activity
G7048_RS00220	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G7048_RS00225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7048_RS00225	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G7048_RS00250	COG0175	sulfate reduction
G7048_RS00260	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G7048_RS00265	COG0492	ferredoxin-NADP+ reductase activity
G7048_RS00290	COG0351	phosphomethylpyrimidine kinase
G7048_RS00305	COG2022	thiamine diphosphate biosynthetic process
G7048_RS00315	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7048_RS00320	COG1024	Enoyl-CoA hydratase
G7048_RS00335	COG1960	acyl-CoA dehydrogenase activity
G7048_RS00350	COG3842	ATPase activity
G7048_RS00375	COG1414	Transcriptional regulator
G7048_RS00385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G7048_RS00390	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G7048_RS00395	COG0440	acetolactate synthase activity
G7048_RS00400	COG0028	Belongs to the TPP enzyme family
G7048_RS00425	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G7048_RS00435	COG0347	Belongs to the P(II) protein family
G7048_RS00450	COG0835	chemotaxis
G7048_RS00455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G7048_RS00475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G7048_RS00500	COG0328	RNA-DNA hybrid ribonuclease activity
G7048_RS00505	COG2226	methyltransferase
G7048_RS00510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7048_RS00515	COG1388	LysM domain
G7048_RS00515	COG0741	lytic transglycosylase activity
G7048_RS00520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G7048_RS00530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G7048_RS00535	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G7048_RS00580	COG3118	belongs to the thioredoxin family
G7048_RS00585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G7048_RS00590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7048_RS00595	COG0842	Transport permease protein
G7048_RS00595	COG1129	ABC transporter
G7048_RS00600	COG0842	Transport permease protein
G7048_RS00605	COG0254	rRNA binding
G7048_RS00615	COG0534	Mate efflux family protein
G7048_RS00625	COG0745	RESPONSE REGULATOR receiver
G7048_RS00630	COG0704	Plays a role in the regulation of phosphate uptake
G7048_RS00635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G7048_RS00640	COG0581	inorganic phosphate transmembrane transporter activity
G7048_RS00645	COG0573	inorganic phosphate transmembrane transporter activity
G7048_RS00650	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G7048_RS00675	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G7048_RS00685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G7048_RS00695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G7048_RS00700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G7048_RS00705	COG1534	Rna-binding protein
G7048_RS00720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G7048_RS00725	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G7048_RS00730	COG0505	Belongs to the CarA family
G7048_RS00735	COG3781	membrane
G7048_RS00785	COG0037	tRNA processing
G7048_RS00790	COG0825	malonyl-CoA metabolic process
G7048_RS00800	COG0215	cysteine-tRNA ligase activity
G7048_RS00835	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS00845	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G7048_RS00850	COG1522	sequence-specific DNA binding
G7048_RS00860	COG0583	DNA-binding transcription factor activity
G7048_RS00865	COG1741	Belongs to the pirin family
G7048_RS00880	COG1574	metal-dependent hydrolase with the TIM-barrel fold
G7048_RS00905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G7048_RS00925	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G7048_RS00925	COG0506	proline dehydrogenase activity
G7048_RS00925	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G7048_RS00930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7048_RS00990	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G7048_RS01025	COG5002	protein histidine kinase activity
G7048_RS01045	COG0084	hydrolase, TatD family'
G7048_RS01050	COG2003	Belongs to the UPF0758 family
G7048_RS01075	COG1475	DNA binding
G7048_RS01090	COG5489	Protein of unknown function (DUF736)
G7048_RS01110	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
G7048_RS01165	COG4959	Type IV secretory pathway protease TraF
G7048_RS01180	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS01190	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS01195	COG0477	Major facilitator Superfamily
G7048_RS01205	COG0583	DNA-binding transcription factor activity
G7048_RS01215	COG3209	COG3209 Rhs family protein
G7048_RS01220	COG1917	Cupin 2, conserved barrel domain protein
G7048_RS01220	COG4977	sequence-specific DNA binding
G7048_RS01235	COG0583	DNA-binding transcription factor activity
G7048_RS01255	COG3135	benzoate transporter
G7048_RS01270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G7048_RS01275	COG0159	tryptophan synthase activity
G7048_RS01280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G7048_RS01285	COG0583	DNA-binding transcription factor activity
G7048_RS01310	COG4962	Type ii secretion system protein e
G7048_RS01315	COG3838	Conjugal transfer protein Trbc
G7048_RS01325	COG3451	type IV secretory pathway VirB4
G7048_RS01350	COG3504	Conjugal transfer protein
G7048_RS01355	COG2948	multi-organism process
G7048_RS01385	COG0582	viral genome integration into host DNA
G7048_RS01390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G7048_RS01390	COG0519	Catalyzes the synthesis of GMP from XMP
G7048_RS01415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7048_RS01450	COG0251	oxidation-reduction process
G7048_RS01455	COG0129	dihydroxy-acid dehydratase activity
G7048_RS01475	COG2867	negative regulation of translational initiation
G7048_RS01480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G7048_RS01490	COG1024	Enoyl-CoA hydratase
G7048_RS01540	COG0683	leucine binding
G7048_RS01545	COG0004	ammonium transporteR
G7048_RS01560	COG2249	NAD(P)H dehydrogenase (quinone) activity
G7048_RS01570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G7048_RS01575	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G7048_RS01580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G7048_RS01585	COG0195	Participates in both transcription termination and antitermination
G7048_RS01590	COG0779	Required for maturation of 30S ribosomal subunits
G7048_RS01600	COG2010	Cytochrome c
G7048_RS01600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G7048_RS01610	COG4221	oxidoreductase activity
G7048_RS01615	COG0557	exoribonuclease II activity
G7048_RS01655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7048_RS01665	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
G7048_RS01690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7048_RS01705	COG2863	cytochrome
G7048_RS01715	COG1304	FMN binding
G7048_RS01725	COG3842	ATPase activity
G7048_RS01730	COG1178	ABC-type Fe3 transport system permease component
G7048_RS01735	COG1840	ABC-type Fe3 transport system, periplasmic component
G7048_RS01740	COG1960	acyl-CoA dehydrogenase activity
G7048_RS01760	COG0183	Belongs to the thiolase family
G7048_RS01765	COG1024	Enoyl-CoA hydratase
G7048_RS01765	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7048_RS01770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G7048_RS01780	COG0411	ABC transporter
G7048_RS01790	COG0559	Belongs to the binding-protein-dependent transport system permease family
G7048_RS01795	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS01800	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G7048_RS01805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G7048_RS01810	COG2917	probably involved in intracellular septation
G7048_RS01820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7048_RS01850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G7048_RS01855	COG0517	IMP dehydrogenase activity
G7048_RS01855	COG1125	glycine betaine transport
G7048_RS01860	COG0688	phosphatidylethanolamine metabolic process
G7048_RS01900	COG0582	viral genome integration into host DNA
G7048_RS01910	COG0546	phosphoglycolate phosphatase activity
G7048_RS01915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G7048_RS01930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G7048_RS01940	COG0287	Prephenate dehydrogenase
G7048_RS01945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G7048_RS01955	COG0776	regulation of translation
G7048_RS01965	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G7048_RS01975	COG2111	Na H antiporter
G7048_RS01975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G7048_RS01980	COG1006	Multisubunit Na H antiporter MnhC subunit
G7048_RS01985	COG0651	ATP synthesis coupled electron transport
G7048_RS01995	COG2212	antiporter activity
G7048_RS02010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G7048_RS02015	COG1611	Belongs to the LOG family
G7048_RS02020	COG0840	transmembrane signaling receptor activity
G7048_RS02035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7048_RS02045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G7048_RS02050	COG0824	Thioesterase
G7048_RS02105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G7048_RS02125	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
G7048_RS02130	COG0285	dihydrofolate synthase activity
G7048_RS02135	COG1393	Belongs to the ArsC family
G7048_RS02145	COG3123	guanosine phosphorylase activity
G7048_RS02150	COG0137	argininosuccinate synthase activity
G7048_RS02155	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS02170	COG1666	GTP binding
G7048_RS02175	COG3577	Aspartyl protease
G7048_RS02185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G7048_RS02190	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G7048_RS02195	COG0667	Aldo Keto reductase
G7048_RS02200	COG2267	carboxylic ester hydrolase activity
G7048_RS02205	COG4585	Histidine kinase
G7048_RS02220	COG0308	aminopeptidase N
G7048_RS02225	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G7048_RS02235	COG0582	viral genome integration into host DNA
G7048_RS02295	COG1113	amino acid transport
G7048_RS02320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G7048_RS02325	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS02360	COG0824	Thioesterase
G7048_RS02365	COG2986	histidine ammonia-lyase
G7048_RS02390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G7048_RS02395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G7048_RS02400	COG0204	Acyl-transferase
G7048_RS02430	COG0753	catalase activity
G7048_RS02450	COG1053	succinate dehydrogenase
G7048_RS02450	COG3976	FMN-binding domain protein
G7048_RS02455	COG3473	Maleate cis-trans isomerase
G7048_RS02465	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS02470	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G7048_RS02475	COG0583	DNA-binding transcription factor activity
G7048_RS02480	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS02495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS02500	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G7048_RS02505	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS02510	COG1024	Enoyl-CoA hydratase
G7048_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS02520	COG1960	acyl-CoA dehydrogenase activity
G7048_RS02525	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7048_RS02530	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7048_RS02545	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7048_RS02625	COG1802	Transcriptional regulator
G7048_RS02640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7048_RS02650	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS02660	COG0583	DNA-binding transcription factor activity
G7048_RS02670	COG0789	Transcriptional regulator
G7048_RS02675	COG0776	regulation of translation
G7048_RS02680	COG0072	phenylalanine-tRNA ligase activity
G7048_RS02680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7048_RS02685	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G7048_RS02690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G7048_RS02695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G7048_RS02700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G7048_RS02705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G7048_RS02715	COG1858	cytochrome C peroxidase
G7048_RS02725	COG2224	Isocitrate lyase
G7048_RS02735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7048_RS02775	COG3193	protein, possibly involved in utilization of glycolate and propanediol
G7048_RS02780	COG0670	Belongs to the BI1 family
G7048_RS02785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G7048_RS02790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G7048_RS02795	COG3064	Membrane
G7048_RS02810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G7048_RS02815	COG1960	acyl-CoA dehydrogenase activity
G7048_RS02830	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS02835	COG0583	DNA-binding transcription factor activity
G7048_RS02845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS02855	COG1525	nuclease
G7048_RS02870	COG2719	SpoVR family
G7048_RS02875	COG2718	Belongs to the UPF0229 family
G7048_RS02880	COG2766	serine protein kinase
G7048_RS02890	COG0564	pseudouridine synthase activity
G7048_RS02905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G7048_RS02920	COG0028	Belongs to the TPP enzyme family
G7048_RS02930	COG1752	Esterase of the alpha-beta hydrolase superfamily
G7048_RS02940	COG2918	glutathione biosynthetic process
G7048_RS02945	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS02960	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G7048_RS02965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G7048_RS02970	COG0436	Aminotransferase
G7048_RS02975	COG0824	Thioesterase
G7048_RS03005	COG0477	Major facilitator Superfamily
G7048_RS03010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G7048_RS03015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G7048_RS03020	COG1845	cytochrome c oxidase, subunit III
G7048_RS03025	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G7048_RS03040	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
G7048_RS03045	COG2954	triphosphatase activity
G7048_RS03070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS03080	COG1960	acyl-CoA dehydrogenase activity
G7048_RS03085	COG0583	DNA-binding transcription factor activity
G7048_RS03110	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G7048_RS03135	COG4106	trans-aconitate 2-methyltransferase activity
G7048_RS03140	COG0039	L-malate dehydrogenase activity
G7048_RS03145	COG2188	Transcriptional regulator
G7048_RS03150	COG2009	succinate dehydrogenase
G7048_RS03160	COG1053	succinate dehydrogenase
G7048_RS03165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G7048_RS03170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G7048_RS03175	COG0372	Belongs to the citrate synthase family
G7048_RS03185	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G7048_RS03190	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G7048_RS03215	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS03230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G7048_RS03245	COG0583	DNA-binding transcription factor activity
G7048_RS03270	COG1960	acyl-CoA dehydrogenase activity
G7048_RS03285	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
G7048_RS03285	COG3264	Mechanosensitive ion channel
G7048_RS03295	COG0123	including yeast histone deacetylase and acetoin utilization protein
G7048_RS03300	COG0714	Associated with various cellular activities
G7048_RS03315	COG2951	lytic endotransglycosylase activity
G7048_RS03320	COG0683	leucine binding
G7048_RS03340	COG0577	efflux transmembrane transporter activity
G7048_RS03340	COG1136	(ABC) transporter
G7048_RS03345	COG0577	efflux transmembrane transporter activity
G7048_RS03345	COG1136	(ABC) transporter
G7048_RS03350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7048_RS03365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G7048_RS03370	COG0516	GMP reductase activity
G7048_RS03370	COG0517	IMP dehydrogenase activity
G7048_RS03385	COG1230	cation diffusion facilitator family transporter
G7048_RS03390	COG0745	RESPONSE REGULATOR receiver
G7048_RS03395	COG2205	protein histidine kinase activity
G7048_RS03400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7048_RS03405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G7048_RS03575	COG5484	DNA packaging
G7048_RS03575	COG3728	DNA packaging
G7048_RS03600	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
G7048_RS03610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G7048_RS03660	COG0582	viral genome integration into host DNA
G7048_RS03680	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G7048_RS03790	COG0740	serine-type endopeptidase activity
G7048_RS03930	COG0582	viral genome integration into host DNA
G7048_RS03940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G7048_RS03950	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS03960	COG0745	RESPONSE REGULATOR receiver
G7048_RS03965	COG2205	protein histidine kinase activity
G7048_RS03970	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G7048_RS03970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G7048_RS03975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G7048_RS03975	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G7048_RS03980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G7048_RS03995	COG0560	Phosphoserine phosphatase
G7048_RS04000	COG1464	Belongs to the NlpA lipoprotein family
G7048_RS04020	COG0583	DNA-binding transcription factor activity
G7048_RS04025	COG0583	DNA-binding transcription factor activity
G7048_RS04030	COG1840	ABC-type Fe3 transport system, periplasmic component
G7048_RS04035	COG3842	ATPase activity
G7048_RS04050	COG1882	Formate acetyltransferase
G7048_RS04060	COG3530	Putative quorum-sensing-regulated virulence factor
G7048_RS04065	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS04070	COG0154	amidase activity
G7048_RS04075	COG0583	DNA-binding transcription factor activity
G7048_RS04080	COG0667	Aldo Keto reductase
G7048_RS04085	COG2900	Belongs to the SlyX family
G7048_RS04090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7048_RS04105	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G7048_RS04120	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G7048_RS04125	COG1492	cobalamin metabolic process
G7048_RS04140	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
G7048_RS04145	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G7048_RS04150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G7048_RS04155	COG4607	ABC-type enterochelin transport system periplasmic component
G7048_RS04165	COG4206	TonB-dependent receptor
G7048_RS04190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7048_RS04205	COG0348	domain, Protein
G7048_RS04225	COG3278	Belongs to the heme-copper respiratory oxidase family
G7048_RS04235	COG2217	Heavy metal translocating P-type atpase
G7048_RS04250	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS04265	COG1024	Enoyl-CoA hydratase
G7048_RS04285	COG1802	Transcriptional regulator
G7048_RS04290	COG1414	Transcriptional regulator
G7048_RS04315	COG2267	carboxylic ester hydrolase activity
G7048_RS04325	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
G7048_RS04330	COG1295	ribonuclease BN
G7048_RS04340	COG0277	FAD linked oxidase domain protein
G7048_RS04350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G7048_RS04360	COG0708	Exodeoxyribonuclease III
G7048_RS04390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G7048_RS04395	COG1737	Transcriptional regulator
G7048_RS04405	COG3852	Histidine kinase
G7048_RS04415	COG0174	glutamine synthetase
G7048_RS04445	COG1187	pseudouridine synthase activity
G7048_RS04480	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G7048_RS04485	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G7048_RS04490	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
G7048_RS04495	COG0330	HflC and HflK could
G7048_RS04500	COG0330	HflC and HflK could
G7048_RS04505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G7048_RS04510	COG1923	regulation of RNA biosynthetic process
G7048_RS04515	COG1160	GTP binding
G7048_RS04530	COG0124	histidyl-tRNA synthetase
G7048_RS04550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G7048_RS04555	COG0105	UTP biosynthetic process
G7048_RS04560	COG1187	pseudouridine synthase activity
G7048_RS04565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G7048_RS04570	COG0564	pseudouridine synthase activity
G7048_RS04580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G7048_RS04585	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G7048_RS04590	COG3540	Alkaline phosphatase
G7048_RS04595	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7048_RS04610	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
G7048_RS04620	COG0583	DNA-binding transcription factor activity
G7048_RS04625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G7048_RS04645	COG3275	phosphorelay sensor kinase activity
G7048_RS04675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G7048_RS04695	COG1968	undecaprenyl-diphosphatase activity
G7048_RS04705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7048_RS04710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G7048_RS04715	COG2916	Histone family protein nucleoid-structuring protein H-NS
G7048_RS04720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G7048_RS04740	COG4263	nitrous-oxide reductase activity
G7048_RS04745	COG3901	Regulator of nitric oxide reductase transcription
G7048_RS04745	COG0348	domain, Protein
G7048_RS04760	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
G7048_RS04775	COG0741	lytic transglycosylase activity
G7048_RS04800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G7048_RS04805	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
G7048_RS04810	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G7048_RS04825	COG2850	peptidyl-arginine hydroxylation
G7048_RS04830	COG1047	Peptidyl-prolyl cis-trans
G7048_RS04840	COG0756	dUTP diphosphatase activity
G7048_RS04850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G7048_RS04855	COG0504	CTP synthase activity
G7048_RS04860	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G7048_RS04870	COG0148	phosphopyruvate hydratase activity
G7048_RS04875	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G7048_RS04895	COG2833	Protein of unknown function (DUF455)
G7048_RS04910	COG4974	Belongs to the 'phage' integrase family
G7048_RS04915	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS04925	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G7048_RS04930	COG0802	atpase or kinase
G7048_RS04935	COG0860	N-Acetylmuramoyl-L-alanine amidase
G7048_RS04945	COG0586	Pfam SNARE associated Golgi protein
G7048_RS04950	COG1131	(ABC) transporter
G7048_RS04965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G7048_RS04975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G7048_RS04990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7048_RS05030	COG1216	Glycosyl transferase, family 2
G7048_RS05030	COG0463	Glycosyl transferase, family 2
G7048_RS05045	COG1007	ATP synthesis coupled electron transport
G7048_RS05060	COG0713	ATP synthesis coupled electron transport
G7048_RS05070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7048_RS05075	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G7048_RS05080	COG1034	ATP synthesis coupled electron transport
G7048_RS05085	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G7048_RS05095	COG0649	NAD binding
G7048_RS05100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7048_RS05105	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7048_RS05110	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7048_RS05125	COG0149	triose-phosphate isomerase activity
G7048_RS05130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G7048_RS05130	COG0604	alcohol dehydrogenase
G7048_RS05130	COG4221	oxidoreductase activity
G7048_RS05130	COG3321	synthase
G7048_RS05135	COG1185	polyribonucleotide nucleotidyltransferase activity
G7048_RS05140	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G7048_RS05155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G7048_RS05160	COG1758	RNA polymerase activity
G7048_RS05165	COG0194	GDP metabolic process
G7048_RS05170	COG1561	YicC-like family, N-terminal region
G7048_RS05190	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G7048_RS05195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G7048_RS05225	COG1420	regulation of RNA biosynthetic process
G7048_RS05230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G7048_RS05235	COG0497	DNA recombination
G7048_RS05240	COG1660	Displays ATPase and GTPase activities
G7048_RS05245	COG1194	a g-specific adenine glycosylase
G7048_RS05255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G7048_RS05270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G7048_RS05280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G7048_RS05285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G7048_RS05290	COG0193	aminoacyl-tRNA hydrolase activity
G7048_RS05295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G7048_RS05300	COG0601	transmembrane transport
G7048_RS05305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G7048_RS05315	COG4608	Belongs to the ABC transporter superfamily
G7048_RS05320	COG0747	negative chemotaxis
G7048_RS05325	COG0154	amidase activity
G7048_RS05330	COG1280	lysine exporter protein (LysE YggA)
G7048_RS05360	COG0302	gtp cyclohydrolase
G7048_RS05385	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G7048_RS05400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G7048_RS05405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G7048_RS05425	COG2226	methyltransferase
G7048_RS05445	COG1960	acyl-CoA dehydrogenase activity
G7048_RS05450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G7048_RS05465	COG0431	NADPH-dependent FMN reductase
G7048_RS05475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G7048_RS05490	COG0395	ABC-type sugar transport system, permease component
G7048_RS05495	COG3842	ATPase activity
G7048_RS05505	COG0584	glycerophosphoryl diester phosphodiesterase
G7048_RS05510	COG1196	nuclear chromosome segregation
G7048_RS05510	COG3264	Mechanosensitive ion channel
G7048_RS05515	COG2375	cellular response to nickel ion
G7048_RS05530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G7048_RS05535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G7048_RS05545	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G7048_RS05550	COG1253	flavin adenine dinucleotide binding
G7048_RS05555	COG0741	lytic transglycosylase activity
G7048_RS05560	COG0442	prolyl-tRNA aminoacylation
G7048_RS05565	COG0494	nUDIX hydrolase
G7048_RS05570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G7048_RS05575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G7048_RS05580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G7048_RS05585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G7048_RS05590	COG0142	geranyltranstransferase activity
G7048_RS05610	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G7048_RS05615	COG0237	dephospho-CoA kinase activity
G7048_RS05620	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
G7048_RS05625	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G7048_RS05630	COG0494	nUDIX hydrolase
G7048_RS05640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G7048_RS05645	COG0653	protein targeting
G7048_RS05660	COG2969	positive regulation of protein catabolic process
G7048_RS05665	COG0625	glutathione transferase activity
G7048_RS05670	COG2857	Cytochrome c1
G7048_RS05675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G7048_RS05680	COG0723	plastoquinol--plastocyanin reductase activity
G7048_RS05685	COG1970	mechanosensitive ion channel activity
G7048_RS05690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G7048_RS05705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7048_RS05710	COG0805	protein transport
G7048_RS05715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G7048_RS05720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G7048_RS05725	COG0537	adenosine 5'-monophosphoramidase activity
G7048_RS05740	COG0140	phosphoribosyl-ATP diphosphatase activity
G7048_RS05745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G7048_RS05760	COG0107	imidazoleglycerol-phosphate synthase activity
G7048_RS05770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G7048_RS05775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G7048_RS05780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G7048_RS05790	COG0131	Imidazoleglycerol-phosphate dehydratase
G7048_RS05795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G7048_RS05820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G7048_RS05825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G7048_RS05835	COG0842	Transport permease protein
G7048_RS05840	COG1131	(ABC) transporter
G7048_RS05860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G7048_RS05865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G7048_RS05870	COG1127	ABC transporter
G7048_RS05875	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
G7048_RS05880	COG1126	abc transporter atp-binding protein
G7048_RS05885	COG0765	amino acid transport
G7048_RS05890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7048_RS05900	COG2814	Major facilitator Superfamily
G7048_RS05905	COG0513	Belongs to the DEAD box helicase family
G7048_RS05910	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G7048_RS05915	COG0501	Belongs to the peptidase M48B family
G7048_RS05920	COG2154	pterin-4-alpha-carbinolamine dehydratase
G7048_RS05925	COG1162	GTPase activity
G7048_RS05930	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
G7048_RS05935	COG0494	nUDIX hydrolase
G7048_RS05940	COG0335	large ribosomal subunit rRNA binding
G7048_RS05945	COG0336	Belongs to the RNA methyltransferase TrmD family
G7048_RS05950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G7048_RS05955	COG0228	four-way junction DNA binding
G7048_RS05970	COG0306	phosphate transporter
G7048_RS05975	COG1392	Phosphate transport regulator
G7048_RS06000	COG0559	Belongs to the binding-protein-dependent transport system permease family
G7048_RS06010	COG0582	viral genome integration into host DNA
G7048_RS06210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G7048_RS06215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G7048_RS06220	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G7048_RS06225	COG1674	ftsk spoiiie
G7048_RS06230	COG0492	ferredoxin-NADP+ reductase activity
G7048_RS06235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G7048_RS06240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G7048_RS06255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G7048_RS06255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G7048_RS06270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G7048_RS06275	COG3132	Protein of unknown function, DUF480
G7048_RS06280	COG1960	acyl-CoA dehydrogenase activity
G7048_RS06285	COG1960	acyl-CoA dehydrogenase activity
G7048_RS06290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G7048_RS06295	COG2011	ABC-type metal ion transport system permease component
G7048_RS06300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G7048_RS06305	COG1464	Belongs to the NlpA lipoprotein family
G7048_RS06315	COG1116	anion transmembrane transporter activity
G7048_RS06350	COG0411	ABC transporter
G7048_RS06375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G7048_RS06395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G7048_RS06400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7048_RS06410	COG1045	serine acetyltransferase
G7048_RS06430	COG0196	riboflavin kinase activity
G7048_RS06435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G7048_RS06440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G7048_RS06470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7048_RS06490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7048_RS06495	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS06505	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G7048_RS06510	COG1473	amidohydrolase
G7048_RS06525	COG0583	DNA-binding transcription factor activity
G7048_RS06555	COG0438	transferase activity, transferring glycosyl groups
G7048_RS06555	COG1216	Glycosyl transferase, family 2
G7048_RS06570	COG2885	chlorophyll binding
G7048_RS06615	COG0210	DNA helicase
G7048_RS06620	COG0516	GMP reductase activity
G7048_RS06655	COG0070	glutamate synthase
G7048_RS06655	COG0069	glutamate synthase activity
G7048_RS06655	COG0067	glutamate synthase
G7048_RS06675	COG1785	Belongs to the alkaline phosphatase family
G7048_RS06690	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G7048_RS06735	COG1965	Belongs to the frataxin family
G7048_RS06750	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
G7048_RS06755	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G7048_RS06760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G7048_RS06765	COG1333	cytochrome c biogenesis protein
G7048_RS06775	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G7048_RS06780	COG1560	Kdo2-lipid A biosynthetic process
G7048_RS06790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G7048_RS06810	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G7048_RS06815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G7048_RS06815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G7048_RS06820	COG1056	cytidyltransferase-related domain
G7048_RS06820	COG1051	belongs to the nudix hydrolase family
G7048_RS06835	COG0438	transferase activity, transferring glycosyl groups
G7048_RS06850	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
G7048_RS06865	COG0463	Glycosyl transferase, family 2
G7048_RS06910	COG0419	ATPase involved in DNA repair
G7048_RS06915	COG0420	3'-5' exonuclease activity
G7048_RS06920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G7048_RS06925	COG0459	protein refolding
G7048_RS06935	COG0166	Belongs to the GPI family
G7048_RS06940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G7048_RS06945	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G7048_RS06965	COG4608	Belongs to the ABC transporter superfamily
G7048_RS06970	COG0444	Belongs to the ABC transporter superfamily
G7048_RS06975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G7048_RS06980	COG1473	amidohydrolase
G7048_RS06995	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
G7048_RS07000	COG1765	OsmC-like protein
G7048_RS07005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G7048_RS07010	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
G7048_RS07080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G7048_RS07100	COG1132	(ABC) transporter
G7048_RS07105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G7048_RS07105	COG0189	ligase activity
G7048_RS07110	COG0189	ligase activity
G7048_RS07110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G7048_RS07115	COG3045	CreA protein
G7048_RS07125	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
G7048_RS07160	COG2207	Transcriptional regulator
G7048_RS07165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G7048_RS07170	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS07175	COG0183	Belongs to the thiolase family
G7048_RS07190	COG0693	protein deglycase activity
G7048_RS07200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G7048_RS07205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7048_RS07210	COG2274	protein secretion by the type I secretion system
G7048_RS07215	COG1538	Outer membrane efflux protein
G7048_RS07250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G7048_RS07260	COG0583	DNA-binding transcription factor activity
G7048_RS07270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G7048_RS07280	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G7048_RS07285	COG0316	Belongs to the HesB IscA family
G7048_RS07290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G7048_RS07295	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G7048_RS07300	COG0515	serine threonine protein kinase
G7048_RS07305	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G7048_RS07310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G7048_RS07315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G7048_RS07325	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G7048_RS07330	COG0745	RESPONSE REGULATOR receiver
G7048_RS07335	COG2205	protein histidine kinase activity
G7048_RS07340	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G7048_RS07345	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
G7048_RS07350	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G7048_RS07360	COG2814	Major facilitator Superfamily
G7048_RS07370	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G7048_RS07385	COG2076	Multidrug Resistance protein
G7048_RS07405	COG1126	abc transporter atp-binding protein
G7048_RS07410	COG0765	amino acid transport
G7048_RS07415	COG0765	amino acid transport
G7048_RS07420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7048_RS07430	COG0583	DNA-binding transcription factor activity
G7048_RS07445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G7048_RS07450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G7048_RS07455	COG0022	dehydrogenase e1 component
G7048_RS07460	COG5265	(ABC) transporter
G7048_RS07465	COG1607	acyl-coa hydrolase
G7048_RS07475	COG2050	protein possibly involved in aromatic compounds catabolism
G7048_RS07480	COG1024	Enoyl-CoA hydratase
G7048_RS07490	COG0183	Belongs to the thiolase family
G7048_RS07495	COG1024	Enoyl-CoA hydratase
G7048_RS07495	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7048_RS07505	COG1960	acyl-CoA dehydrogenase activity
G7048_RS07520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G7048_RS07545	COG2226	methyltransferase
G7048_RS07565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7048_RS07580	COG1450	Type ii and iii secretion system protein
G7048_RS07610	COG2165	general secretion pathway protein
G7048_RS07615	COG4969	Belongs to the N-Me-Phe pilin family
G7048_RS07625	COG1459	type II secretion system
G7048_RS07630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G7048_RS07670	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G7048_RS07675	COG1652	LysM domain
G7048_RS07695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G7048_RS07700	COG0751	glycine-tRNA ligase activity
G7048_RS07705	COG0752	glycyl-tRNA synthetase alpha subunit
G7048_RS07715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G7048_RS07720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G7048_RS07725	COG4535	Mg2 and Co2 transporter CorC
G7048_RS07735	COG0583	DNA-binding transcription factor activity
G7048_RS07745	COG1522	sequence-specific DNA binding
G7048_RS07765	COG3186	Phenylalanine-4-hydroxylase
G7048_RS07775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7048_RS07785	COG4774	siderophore transport
G7048_RS07790	COG3128	pkhd-type hydroxylase
G7048_RS07810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G7048_RS07815	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G7048_RS07825	COG0617	tRNA 3'-terminal CCA addition
G7048_RS07840	COG1877	trehalose-phosphatase activity
G7048_RS07845	COG3387	PFAM Glycoside hydrolase 15-related
G7048_RS07875	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS07890	COG0037	tRNA processing
G7048_RS07915	COG3552	Protein containing von Willebrand factor type A (VWA) domain
G7048_RS07930	COG0326	Molecular chaperone. Has ATPase activity
G7048_RS07935	COG0714	Associated with various cellular activities
G7048_RS07965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G7048_RS07970	COG1285	pathogenesis
G7048_RS07980	COG2255	four-way junction helicase activity
G7048_RS07985	COG1802	Transcriptional regulator
G7048_RS08000	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
G7048_RS08005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G7048_RS08010	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G7048_RS08015	COG4770	biotin carboxylase activity
G7048_RS08035	COG0443	Heat shock 70 kDa protein
G7048_RS08065	COG0632	four-way junction helicase activity
G7048_RS08070	COG1702	phosphate starvation-inducible protein PhoH
G7048_RS08075	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G7048_RS08080	COG0730	response to heat
G7048_RS08085	COG0583	DNA-binding transcription factor activity
G7048_RS08105	COG1490	D-aminoacyl-tRNA deacylase activity
G7048_RS08110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G7048_RS08115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G7048_RS08125	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7048_RS08145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G7048_RS08165	COG0326	Molecular chaperone. Has ATPase activity
G7048_RS08170	COG1187	pseudouridine synthase activity
G7048_RS08175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7048_RS08185	COG3409	Peptidoglycan-binding domain 1 protein
G7048_RS08185	COG3267	Type II secretory pathway component ExeA
G7048_RS08190	COG1022	Amp-dependent synthetase and ligase
G7048_RS08235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G7048_RS08245	COG2818	Glycosylase
G7048_RS08265	COG1473	amidohydrolase
G7048_RS08275	COG0243	molybdopterin cofactor binding
G7048_RS08325	COG3180	Ammonia monooxygenase
G7048_RS08330	COG3945	hemerythrin HHE cation binding domain
G7048_RS08345	COG0288	reversible hydration of carbon dioxide
G7048_RS08350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7048_RS08355	COG2181	nitrate reductase activity
G7048_RS08360	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
G7048_RS08365	COG1140	nitrate reductase beta subunit
G7048_RS08370	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
G7048_RS08375	COG2223	nitrite transmembrane transporter activity
G7048_RS08385	COG2197	response regulator
G7048_RS08390	COG3850	Histidine kinase
G7048_RS08410	COG0583	DNA-binding transcription factor activity
G7048_RS08415	COG0277	FAD linked oxidase domain protein
G7048_RS08425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7048_RS08430	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G7048_RS08440	COG2175	clavaminate synthase activity
G7048_RS08450	COG2733	membrane
G7048_RS08455	COG0545	Peptidyl-prolyl cis-trans isomerase
G7048_RS08465	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G7048_RS08475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7048_RS08485	COG2084	Dehydrogenase
G7048_RS08490	COG2823	Periplasmic or secreted lipoprotein
G7048_RS08495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
G7048_RS08500	COG0792	nuclease activity
G7048_RS08520	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS08550	COG0443	Heat shock 70 kDa protein
G7048_RS08560	COG0203	ribosomal protein L17
G7048_RS08565	COG0202	RNA polymerase activity
G7048_RS08570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G7048_RS08575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G7048_RS08580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G7048_RS08585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G7048_RS08590	COG0201	protein transport
G7048_RS08595	COG0200	Binds to the 23S rRNA
G7048_RS08600	COG1841	ribosomal large subunit assembly
G7048_RS08605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G7048_RS08610	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G7048_RS08615	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G7048_RS08620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G7048_RS08625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G7048_RS08630	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G7048_RS08635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G7048_RS08640	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G7048_RS08645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G7048_RS08660	COG0395	ABC-type sugar transport system, permease component
G7048_RS08675	COG3842	ATPase activity
G7048_RS08685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G7048_RS08690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G7048_RS08720	COG3384	dioxygenase
G7048_RS08725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G7048_RS08735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G7048_RS08745	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS08770	COG0583	DNA-binding transcription factor activity
G7048_RS08775	COG4589	Belongs to the CDS family
G7048_RS08790	COG0671	phosphoesterase, PA-phosphatase related
G7048_RS08790	COG2453	phosphatase
G7048_RS08795	COG2267	carboxylic ester hydrolase activity
G7048_RS08800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G7048_RS08805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G7048_RS08820	COG0134	indole-3-glycerol-phosphate synthase activity
G7048_RS08825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G7048_RS08830	COG0512	Glutamine amidotransferase of anthranilate synthase
G7048_RS08850	COG0840	transmembrane signaling receptor activity
G7048_RS08860	COG0546	phosphoglycolate phosphatase activity
G7048_RS08870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G7048_RS08875	COG2967	ApaG domain
G7048_RS08890	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G7048_RS08915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G7048_RS08920	COG1546	Belongs to the CinA family
G7048_RS08925	COG3318	Belongs to the UPF0149 family
G7048_RS08925	COG3012	SEC-C Motif Domain Protein
G7048_RS08930	COG0069	glutamate synthase activity
G7048_RS08945	COG1960	acyl-CoA dehydrogenase activity
G7048_RS08970	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS08995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G7048_RS09000	COG2076	Multidrug Resistance protein
G7048_RS09015	COG0116	Belongs to the methyltransferase superfamily
G7048_RS09015	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G7048_RS09020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7048_RS09040	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G7048_RS09045	COG1137	ATPase activity
G7048_RS09050	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G7048_RS09055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G7048_RS09065	COG0018	arginyl-trna synthetase
G7048_RS09095	COG5002	protein histidine kinase activity
G7048_RS09100	COG0745	RESPONSE REGULATOR receiver
G7048_RS09110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G7048_RS09125	COG1215	transferase activity, transferring glycosyl groups
G7048_RS09145	COG1696	Membrane protein involved in D-alanine export
G7048_RS09150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G7048_RS09155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G7048_RS09185	COG1942	4-Oxalocrotonate Tautomerase
G7048_RS09190	COG2814	Major facilitator Superfamily
G7048_RS09195	COG0121	glutamine amidotransferase
G7048_RS09265	COG1704	LemA family
G7048_RS09300	COG2770	Histidine kinase
G7048_RS09300	COG2208	phosphoserine phosphatase activity
G7048_RS09345	COG1366	Belongs to the anti-sigma-factor antagonist family
G7048_RS09350	COG4789	Type iii secretion
G7048_RS09420	COG4669	(LipO)protein
G7048_RS09455	COG4790	Type iii secretion
G7048_RS09460	COG4794	Type iii secretion
G7048_RS09465	COG4791	protein targeting
G7048_RS09470	COG4792	protein secretion
G7048_RS09505	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G7048_RS09510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G7048_RS09515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G7048_RS09520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G7048_RS09525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G7048_RS09530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G7048_RS09540	COG0356	it plays a direct role in the translocation of protons across the membrane
G7048_RS09550	COG2921	Belongs to the UPF0250 family
G7048_RS09555	COG0321	lipoyl(octanoyl) transferase activity
G7048_RS09560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G7048_RS09565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G7048_RS09570	COG3604	Transcriptional regulator
G7048_RS09580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G7048_RS09585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7048_RS09600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7048_RS09605	COG3909	cytochrome
G7048_RS09615	COG0456	acetyltransferase
G7048_RS09620	COG1683	Conserved Protein
G7048_RS09625	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS09635	COG0678	peroxiredoxin activity
G7048_RS09640	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G7048_RS09645	COG0255	Belongs to the universal ribosomal protein uL29 family
G7048_RS09650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G7048_RS09655	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G7048_RS09660	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G7048_RS09665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G7048_RS09670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G7048_RS09675	COG0089	rRNA binding
G7048_RS09680	COG0088	Forms part of the polypeptide exit tunnel
G7048_RS09685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G7048_RS09690	COG0051	transcription antitermination factor activity, RNA binding
G7048_RS09695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G7048_RS09700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G7048_RS09705	COG0049	tRNA binding
G7048_RS09710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G7048_RS09715	COG1686	Belongs to the peptidase S11 family
G7048_RS09720	COG2945	thiolester hydrolase activity
G7048_RS09740	COG0501	Belongs to the peptidase M48B family
G7048_RS09750	COG0598	Magnesium transport protein CorA
G7048_RS09755	COG0412	Dienelactone hydrolase
G7048_RS09760	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS09765	COG2095	MarC family integral membrane protein
G7048_RS09770	COG0745	RESPONSE REGULATOR receiver
G7048_RS09775	COG2205	protein histidine kinase activity
G7048_RS09780	COG4452	Inner membrane protein CreD
G7048_RS09805	COG0004	ammonium transporteR
G7048_RS09820	COG0277	FAD linked oxidase domain protein
G7048_RS09820	COG0247	lactate metabolic process
G7048_RS09845	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
G7048_RS09850	COG1802	Transcriptional regulator
G7048_RS09860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G7048_RS09865	COG1127	ABC transporter
G7048_RS09880	COG0175	sulfate reduction
G7048_RS09895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7048_RS09900	COG0765	amino acid transport
G7048_RS09925	COG0768	penicillin binding
G7048_RS09940	COG1077	Cell shape determining protein MreB Mrl
G7048_RS09945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G7048_RS09950	COG0154	amidase activity
G7048_RS09955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G7048_RS09975	COG5001	Diguanylate cyclase
G7048_RS09975	COG3300	MHYT domain
G7048_RS09985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G7048_RS09990	COG0708	Exodeoxyribonuclease III
G7048_RS09995	COG2819	hydrolase of the alpha beta superfamily
G7048_RS10010	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS10025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7048_RS10050	COG1846	Transcriptional regulator
G7048_RS10055	COG1960	acyl-CoA dehydrogenase activity
G7048_RS10070	COG1024	Enoyl-CoA hydratase
G7048_RS10075	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS10080	COG4628	conserved protein (DUF2132)
G7048_RS10105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7048_RS10110	COG0501	Belongs to the peptidase M48B family
G7048_RS10115	COG0697	spore germination
G7048_RS10135	COG2205	protein histidine kinase activity
G7048_RS10140	COG0477	Major facilitator Superfamily
G7048_RS10230	COG1846	Transcriptional regulator
G7048_RS10235	COG0179	Fumarylacetoacetate (FAA) hydrolase
G7048_RS10245	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS10265	COG3971	2-oxopent-4-enoate hydratase activity
G7048_RS10270	COG0410	ABC transporter
G7048_RS10295	COG1858	cytochrome C peroxidase
G7048_RS10305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G7048_RS10320	COG0386	Belongs to the glutathione peroxidase family
G7048_RS10350	COG0247	lactate metabolic process
G7048_RS10355	COG0277	FAD linked oxidase domain protein
G7048_RS10370	COG0004	ammonium transporteR
G7048_RS10375	COG0347	Belongs to the P(II) protein family
G7048_RS10415	COG1846	Transcriptional regulator
G7048_RS10420	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS10425	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G7048_RS10435	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS10460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G7048_RS10470	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS10485	COG0583	DNA-binding transcription factor activity
G7048_RS10495	COG4585	Histidine kinase
G7048_RS10500	COG1346	cytolysis
G7048_RS10510	COG0583	DNA-binding transcription factor activity
G7048_RS10535	COG1187	pseudouridine synthase activity
G7048_RS10545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G7048_RS10545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G7048_RS10575	COG2072	flavoprotein involved in K transport
G7048_RS10580	COG0601	transmembrane transport
G7048_RS10585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G7048_RS10590	COG0444	Belongs to the ABC transporter superfamily
G7048_RS10595	COG4608	Belongs to the ABC transporter superfamily
G7048_RS10600	COG0747	negative chemotaxis
G7048_RS10620	COG1301	dicarboxylic acid transport
G7048_RS10630	COG0133	tryptophan synthase activity
G7048_RS10645	COG0584	glycerophosphoryl diester phosphodiesterase
G7048_RS10665	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
G7048_RS10665	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
G7048_RS10670	COG1396	sequence-specific DNA binding
G7048_RS10675	COG3550	peptidyl-serine autophosphorylation
G7048_RS10680	COG1410	methionine synthase
G7048_RS10680	COG0646	methionine synthase
G7048_RS10700	COG4829	muconolactone delta-isomerase
G7048_RS10710	COG0583	DNA-binding transcription factor activity
G7048_RS10730	COG0583	DNA-binding transcription factor activity
G7048_RS10760	COG2814	Major facilitator Superfamily
G7048_RS10765	COG2326	polyphosphate kinase activity
G7048_RS10770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G7048_RS10780	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS10790	COG2188	Transcriptional regulator
G7048_RS10795	COG2207	Transcriptional regulator
G7048_RS10800	COG2223	nitrite transmembrane transporter activity
G7048_RS10810	COG3949	Membrane
G7048_RS10825	COG1414	Transcriptional regulator
G7048_RS10830	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G7048_RS10860	COG1960	acyl-CoA dehydrogenase activity
G7048_RS10865	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
G7048_RS10895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G7048_RS10895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G7048_RS10905	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G7048_RS10950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G7048_RS10955	COG1960	acyl-CoA dehydrogenase activity
G7048_RS10960	COG0745	RESPONSE REGULATOR receiver
G7048_RS10970	COG1073	alpha beta
G7048_RS10970	COG2226	methyltransferase
G7048_RS10995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G7048_RS11025	COG1760	l-serine dehydratase
G7048_RS11050	COG0583	DNA-binding transcription factor activity
G7048_RS11055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7048_RS11090	COG1073	alpha beta
G7048_RS11095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G7048_RS11100	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G7048_RS11110	COG0850	regulation of cytokinetic process
G7048_RS11120	COG1183	phosphatidylcholine synthase activity
G7048_RS11130	COG1960	acyl-CoA dehydrogenase activity
G7048_RS11135	COG1960	acyl-CoA dehydrogenase activity
G7048_RS11140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS11150	COG0583	DNA-binding transcription factor activity
G7048_RS11195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS11205	COG2233	PERMEase
G7048_RS11220	COG2050	protein possibly involved in aromatic compounds catabolism
G7048_RS11240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7048_RS11250	COG2096	Adenosyltransferase
G7048_RS11260	COG0277	FAD linked oxidase domain protein
G7048_RS11285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7048_RS11355	COG5507	3-demethylubiquinone-9 3-methyltransferase
G7048_RS11365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G7048_RS11380	COG1475	DNA binding
G7048_RS11390	COG1192	Involved in chromosome partitioning
G7048_RS11400	COG0357	Ribosomal RNA small subunit methyltransferase G
G7048_RS11405	COG0445	tRNA wobble uridine modification
G7048_RS11415	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS11420	COG0179	Fumarylacetoacetate (FAA) hydrolase
G7048_RS11445	COG1902	pentaerythritol trinitrate reductase activity
G7048_RS11475	COG2217	Heavy metal translocating P-type atpase
G7048_RS11480	COG4772	TonB-dependent receptor
G7048_RS11490	COG3284	Transcriptional regulator
G7048_RS11525	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7048_RS11535	COG4654	Cytochrome c, class I
G7048_RS11555	COG0789	Transcriptional regulator
G7048_RS11560	COG0583	DNA-binding transcription factor activity
G7048_RS11570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7048_RS11580	COG2715	membrane protein required for spore maturation
G7048_RS11590	COG0583	DNA-binding transcription factor activity
G7048_RS11605	COG2205	protein histidine kinase activity
G7048_RS11605	COG0784	Response regulator, receiver
G7048_RS11610	COG1301	dicarboxylic acid transport
G7048_RS11615	COG2974	May be involved in recombination
G7048_RS11645	COG1024	Enoyl-CoA hydratase
G7048_RS11660	COG1960	acyl-CoA dehydrogenase activity
G7048_RS11665	COG1960	acyl-CoA dehydrogenase activity
G7048_RS11670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G7048_RS11680	COG0791	NLP P60 protein
G7048_RS11685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G7048_RS11700	COG2176	DNA-directed DNA polymerase activity
G7048_RS11715	COG1199	ATP-dependent helicase activity
G7048_RS11720	COG1074	ATP-dependent DNA helicase activity
G7048_RS11730	COG3707	response regulator
G7048_RS11735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G7048_RS11740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7048_RS11745	COG1116	anion transmembrane transporter activity
G7048_RS11750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G7048_RS11755	COG2146	nitrite reductase [NAD(P)H] activity
G7048_RS11760	COG0243	molybdopterin cofactor binding
G7048_RS11770	COG1764	response to oxidative stress
G7048_RS11795	COG5002	protein histidine kinase activity
G7048_RS11810	COG0829	nickel cation binding
G7048_RS11830	COG0559	Belongs to the binding-protein-dependent transport system permease family
G7048_RS11840	COG0831	urea catabolic process
G7048_RS11850	COG0832	Belongs to the urease beta subunit family
G7048_RS11855	COG0804	urea catabolic process
G7048_RS11865	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
G7048_RS11870	COG0830	nickel cation binding
G7048_RS11875	COG2329	Antibiotic biosynthesis monooxygenase
G7048_RS11880	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G7048_RS11885	COG1414	Transcriptional regulator
G7048_RS11900	COG1024	Enoyl-CoA hydratase
G7048_RS11905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS11915	COG0028	Belongs to the TPP enzyme family
G7048_RS11920	COG1024	Enoyl-CoA hydratase
G7048_RS11930	COG0430	RNA-3'-phosphate cyclase activity
G7048_RS11935	COG3541	Predicted nucleotidyltransferase
G7048_RS11940	COG1690	Belongs to the RtcB family
G7048_RS11950	COG4650	regulator
G7048_RS11955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7048_RS11965	COG0765	amino acid transport
G7048_RS11985	COG0659	secondary active sulfate transmembrane transporter activity
G7048_RS11995	COG1475	DNA binding
G7048_RS12090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G7048_RS12095	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G7048_RS12100	COG0594	ribonuclease P activity
G7048_RS12105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G7048_RS12110	COG0706	membrane insertase activity
G7048_RS12120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G7048_RS12125	COG3622	Belongs to the hyi family
G7048_RS12140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G7048_RS12165	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS12170	COG0724	RNA recognition motif
G7048_RS12175	COG0724	RNA recognition motif
G7048_RS12180	COG2119	membrane
G7048_RS12185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G7048_RS12190	COG2226	methyltransferase
G7048_RS12200	COG2267	carboxylic ester hydrolase activity
G7048_RS12215	COG3668	Plasmid stabilization system
G7048_RS12220	COG1196	nuclear chromosome segregation
G7048_RS12235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G7048_RS12245	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G7048_RS12250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7048_RS12255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G7048_RS12310	COG0494	nUDIX hydrolase
G7048_RS12320	COG0307	riboflavin synthase, alpha
G7048_RS12345	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G7048_RS12370	COG1414	Transcriptional regulator
G7048_RS12380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G7048_RS12385	COG0439	Biotin carboxylase
G7048_RS12390	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G7048_RS12395	COG1024	Enoyl-CoA hydratase
G7048_RS12395	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7048_RS12415	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G7048_RS12420	COG2197	response regulator
G7048_RS12425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7048_RS12430	COG1305	Transglutaminase-like
G7048_RS12450	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS12455	COG1802	Transcriptional regulator
G7048_RS12465	COG0559	Belongs to the binding-protein-dependent transport system permease family
G7048_RS12470	COG4177	L-phenylalanine transmembrane transporter activity
G7048_RS12490	COG1744	ABC transporter substrate-binding protein PnrA-like
G7048_RS12510	COG0402	S-adenosylhomocysteine deaminase activity
G7048_RS12530	COG0235	Class ii aldolase
G7048_RS12545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G7048_RS12555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS12560	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS12580	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS12595	COG0443	Heat shock 70 kDa protein
G7048_RS12605	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7048_RS12610	COG0482	sulfurtransferase activity
G7048_RS12615	COG1620	l-lactate permease
G7048_RS12625	COG2084	Dehydrogenase
G7048_RS12630	COG3622	Belongs to the hyi family
G7048_RS12635	COG3960	tartronate-semialdehyde synthase activity
G7048_RS12640	COG0583	DNA-binding transcription factor activity
G7048_RS12645	COG1349	DNA-binding transcription factor activity
G7048_RS12650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G7048_RS12655	COG1454	alcohol dehydrogenase
G7048_RS12660	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G7048_RS12665	COG3395	kinase activity
G7048_RS12680	COG5001	Diguanylate cyclase
G7048_RS12680	COG3300	MHYT domain
G7048_RS12685	COG0629	single-stranded DNA binding
G7048_RS12690	COG2814	Major facilitator Superfamily
G7048_RS12710	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS12735	COG0284	orotidine-5'-phosphate decarboxylase activity
G7048_RS12755	COG0126	phosphoglycerate kinase activity
G7048_RS12770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G7048_RS12780	COG0242	peptide deformylase activity
G7048_RS12790	COG0758	DNA mediated transformation
G7048_RS12795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G7048_RS12800	COG0045	succinate-CoA ligase (ADP-forming) activity
G7048_RS12805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G7048_RS12810	COG0861	Integral membrane protein TerC family
G7048_RS12815	COG0861	Integral membrane protein TerC family
G7048_RS12825	COG1716	ATPase activity
G7048_RS12845	COG2194	sulfuric ester hydrolase activity
G7048_RS12865	COG0315	cyclic pyranopterin monophosphate synthase activity
G7048_RS12870	COG4783	chaperone-mediated protein folding
G7048_RS12875	COG1950	PFAM Membrane protein of
G7048_RS12885	COG0861	Integral membrane protein TerC family
G7048_RS12910	COG0625	glutathione transferase activity
G7048_RS12930	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G7048_RS12950	COG4566	intracellular signal transduction
G7048_RS12960	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
G7048_RS12975	COG1522	sequence-specific DNA binding
G7048_RS12990	COG1862	Preprotein translocase
G7048_RS12995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G7048_RS13000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G7048_RS13015	COG2137	regulation of response to DNA damage stimulus
G7048_RS13020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G7048_RS13030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7048_RS13040	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS13050	COG1802	Transcriptional regulator
G7048_RS13055	COG1840	ABC-type Fe3 transport system, periplasmic component
G7048_RS13060	COG3842	ATPase activity
G7048_RS13080	COG0642	Histidine kinase
G7048_RS13095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS13105	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
G7048_RS13110	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS13115	COG2084	Dehydrogenase
G7048_RS13130	COG0411	ABC transporter
G7048_RS13140	COG3386	PFAM SMP-30 Gluconolaconase
G7048_RS13145	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS13160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS13180	COG1802	Transcriptional regulator
G7048_RS13230	COG1566	PFAM secretion protein HlyD family protein
G7048_RS13265	COG2084	Dehydrogenase
G7048_RS13270	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS13300	COG0463	Glycosyl transferase, family 2
G7048_RS13300	COG0457	Tetratricopeptide repeat
G7048_RS13325	COG0045	succinate-CoA ligase (ADP-forming) activity
G7048_RS13325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G7048_RS13325	COG1042	CoA-binding domain protein
G7048_RS13340	COG0183	Belongs to the thiolase family
G7048_RS13360	COG0300	oxidoreductase activity
G7048_RS13370	COG1047	Peptidyl-prolyl cis-trans
G7048_RS13380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G7048_RS13395	COG2885	chlorophyll binding
G7048_RS13405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G7048_RS13410	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G7048_RS13425	COG0006	proline dipeptidase activity
G7048_RS13480	COG2159	amidohydrolase
G7048_RS13490	COG0179	Fumarylacetoacetate (FAA) hydrolase
G7048_RS13505	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS13515	COG1690	Belongs to the RtcB family
G7048_RS13520	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G7048_RS13525	COG0469	pyruvate kinase activity
G7048_RS13560	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS13565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G7048_RS13570	COG0598	Magnesium transport protein CorA
G7048_RS13585	COG1214	PFAM Peptidase M22, glycoprotease
G7048_RS13610	COG0009	L-threonylcarbamoyladenylate synthase
G7048_RS13615	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G7048_RS13620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G7048_RS13625	COG3118	belongs to the thioredoxin family
G7048_RS13635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G7048_RS13640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G7048_RS13650	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G7048_RS13655	COG0735	belongs to the Fur family
G7048_RS13660	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G7048_RS13665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G7048_RS13690	COG0668	transmembrane transport
G7048_RS13695	COG0495	leucyl-tRNA aminoacylation
G7048_RS13725	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS13735	COG2030	dehydratase
G7048_RS13745	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS13755	COG0662	Cupin 2, conserved barrel domain protein
G7048_RS13760	COG4953	penicillin-binding protein 1C
G7048_RS13765	COG2373	Large extracellular alpha-helical protein
G7048_RS13770	COG3639	organic phosphonate transmembrane transporter activity
G7048_RS13775	COG3639	organic phosphonate transmembrane transporter activity
G7048_RS13780	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G7048_RS13805	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G7048_RS13810	COG0569	domain protein
G7048_RS13815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G7048_RS13825	COG3158	transport of potassium into the cell
G7048_RS13830	COG3135	benzoate transporter
G7048_RS13835	COG0189	ligase activity
G7048_RS13885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G7048_RS13905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G7048_RS13910	COG0081	regulation of translation
G7048_RS13915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G7048_RS13920	COG0222	ribosome binding
G7048_RS13925	COG0085	RNA polymerase activity
G7048_RS13930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G7048_RS13940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G7048_RS13940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G7048_RS13950	COG5000	phosphorelay sensor kinase activity
G7048_RS13955	COG2204	response regulator
G7048_RS14015	COG0582	viral genome integration into host DNA
G7048_RS14020	COG1595	DNA-templated transcription, initiation
G7048_RS14025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G7048_RS14040	COG2365	Tyrosine phosphatase family
G7048_RS14075	COG0204	Acyl-transferase
G7048_RS14075	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS14100	COG5002	protein histidine kinase activity
G7048_RS14100	COG5001	Diguanylate cyclase
G7048_RS14100	COG3447	MASE1 domain protein
G7048_RS14105	COG0343	queuine tRNA-ribosyltransferase activity
G7048_RS14130	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS14135	COG1024	Enoyl-CoA hydratase
G7048_RS14140	COG1960	acyl-CoA dehydrogenase activity
G7048_RS14170	COG0210	DNA helicase
G7048_RS14195	COG0679	Auxin Efflux Carrier
G7048_RS14220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G7048_RS14225	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G7048_RS14245	COG1832	CoA-binding protein
G7048_RS14250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G7048_RS14260	COG3706	GGDEF domain
G7048_RS14265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G7048_RS14280	COG3327	negative regulation of DNA-templated transcription, initiation
G7048_RS14290	COG1024	Enoyl-CoA hydratase
G7048_RS14295	COG2050	protein possibly involved in aromatic compounds catabolism
G7048_RS14305	COG3396	Phenylacetate-CoA oxygenase
G7048_RS14310	COG3460	Phenylacetate-CoA oxygenase
G7048_RS14315	COG3396	Phenylacetate-CoA oxygenase
G7048_RS14320	COG2151	metal-sulfur cluster biosynthetic enzyme
G7048_RS14325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G7048_RS14330	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS14335	COG0534	Mate efflux family protein
G7048_RS14380	COG0384	phenazine biosynthesis protein PhzF
G7048_RS14390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7048_RS14400	COG2188	Transcriptional regulator
G7048_RS14410	COG2201	protein-glutamate methylesterase activity
G7048_RS14415	COG2198	Histidine kinase
G7048_RS14415	COG0643	Histidine kinase
G7048_RS14420	COG0835	chemotaxis
G7048_RS14425	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G7048_RS14430	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G7048_RS14435	COG2201	protein-glutamate methylesterase activity
G7048_RS14470	COG0789	Transcriptional regulator
G7048_RS14475	COG1960	acyl-CoA dehydrogenase activity
G7048_RS14480	COG0288	reversible hydration of carbon dioxide
G7048_RS14485	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
G7048_RS14490	COG0183	Belongs to the thiolase family
G7048_RS14510	COG1960	acyl-CoA dehydrogenase activity
G7048_RS14515	COG2323	membrane
G7048_RS14525	COG3012	SEC-C Motif Domain Protein
G7048_RS14530	COG2198	Histidine kinase
G7048_RS14530	COG0784	Response regulator, receiver
G7048_RS14530	COG5002	protein histidine kinase activity
G7048_RS14550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G7048_RS14560	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS14570	COG0025	NhaP-type Na H and K H
G7048_RS14575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G7048_RS14580	COG1024	Enoyl-CoA hydratase
G7048_RS14595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G7048_RS14640	COG0477	Major facilitator Superfamily
G7048_RS14665	COG0683	leucine binding
G7048_RS14670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G7048_RS14680	COG0418	dihydroorotase activity
G7048_RS14695	COG0501	Belongs to the peptidase M48B family
G7048_RS14710	COG2368	4-hydroxyphenylacetate
G7048_RS14730	COG0411	ABC transporter
G7048_RS14740	COG2072	flavoprotein involved in K transport
G7048_RS14760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS14765	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS14775	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS14780	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
G7048_RS14785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G7048_RS14835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7048_RS14840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G7048_RS14850	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G7048_RS14855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G7048_RS14865	COG0583	DNA-binding transcription factor activity
G7048_RS14900	COG0667	Aldo Keto reductase
G7048_RS14905	COG1414	Transcriptional regulator
G7048_RS14915	COG0523	cobalamin synthesis protein
G7048_RS14930	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G7048_RS14935	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G7048_RS14940	COG2001	Belongs to the MraZ family
G7048_RS14945	COG0275	rRNA processing
G7048_RS14960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G7048_RS14965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G7048_RS14970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G7048_RS14975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G7048_RS14980	COG0772	Belongs to the SEDS family
G7048_RS14985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G7048_RS14990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G7048_RS14995	COG1181	Belongs to the D-alanine--D-alanine ligase family
G7048_RS15000	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G7048_RS15010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G7048_RS15015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G7048_RS15020	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G7048_RS15030	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G7048_RS15040	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G7048_RS15045	COG1414	Transcriptional regulator
G7048_RS15050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G7048_RS15055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G7048_RS15075	COG3150	esterase
G7048_RS15080	COG0772	Belongs to the SEDS family
G7048_RS15085	COG0312	modulator of DNA gyrase
G7048_RS15090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G7048_RS15100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G7048_RS15110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7048_RS15115	COG0511	ligase activity, forming carbon-carbon bonds
G7048_RS15120	COG0439	Biotin carboxylase
G7048_RS15125	COG2264	protein methyltransferase activity
G7048_RS15135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7048_RS15150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G7048_RS15150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G7048_RS15180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G7048_RS15190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G7048_RS15200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G7048_RS15220	COG1024	Enoyl-CoA hydratase
G7048_RS15235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7048_RS15245	COG0012	GTP binding
G7048_RS15250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7048_RS15255	COG4771	TonB-dependent receptor
G7048_RS15295	COG1238	metal cluster binding
G7048_RS15300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G7048_RS15305	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G7048_RS15310	COG0138	bifunctional purine biosynthesis protein purh
G7048_RS15320	COG4774	siderophore transport
G7048_RS15330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G7048_RS15335	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G7048_RS15340	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G7048_RS15350	COG1773	rubredoxin
G7048_RS15365	COG0835	chemotaxis
G7048_RS15370	COG0840	transmembrane signaling receptor activity
G7048_RS15375	COG0784	Response regulator, receiver
G7048_RS15375	COG0643	Histidine kinase
G7048_RS15375	COG2198	Histidine kinase
G7048_RS15380	COG1678	Uncharacterized ACR, COG1678
G7048_RS15385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G7048_RS15390	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G7048_RS15395	COG0540	Belongs to the ATCase OTCase family
G7048_RS15410	COG1393	Belongs to the ArsC family
G7048_RS15425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7048_RS15435	COG0642	Histidine kinase
G7048_RS15655	COG0740	serine-type endopeptidase activity
G7048_RS15805	COG0729	surface antigen
G7048_RS15820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G7048_RS15865	COG1414	Transcriptional regulator
G7048_RS15875	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G7048_RS15880	COG0183	Belongs to the thiolase family
G7048_RS15885	COG0596	Alpha beta hydrolase
G7048_RS15890	COG4829	muconolactone delta-isomerase
G7048_RS15900	COG1280	lysine exporter protein (LysE YggA)
G7048_RS15905	COG1192	Involved in chromosome partitioning
G7048_RS15920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G7048_RS15925	COG1040	competence protein
G7048_RS15930	COG2226	methyltransferase
G7048_RS15945	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
G7048_RS15980	COG0109	protoheme IX farnesyltransferase activity
G7048_RS15985	COG1999	signal sequence binding
G7048_RS15995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G7048_RS16000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G7048_RS16035	COG0612	Peptidase, M16
G7048_RS16040	COG0612	Peptidase, M16
G7048_RS16045	COG0742	ribosomal rna small subunit methyltransferase
G7048_RS16055	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS16060	COG3268	Saccharopine dehydrogenase
G7048_RS16080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G7048_RS16090	COG0697	spore germination
G7048_RS16095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G7048_RS16120	COG5487	UPF0391 membrane protein
G7048_RS16125	COG4585	Histidine kinase
G7048_RS16130	COG2197	response regulator
G7048_RS16145	COG0793	Belongs to the peptidase S41A family
G7048_RS16150	COG0588	phosphoglycerate mutase activity
G7048_RS16155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G7048_RS16165	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G7048_RS16170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G7048_RS16185	COG0583	DNA-binding transcription factor activity
G7048_RS16195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G7048_RS16235	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G7048_RS16270	COG3829	transcription factor binding
G7048_RS16305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G7048_RS16365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7048_RS16365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7048_RS16380	COG0489	protein tyrosine kinase activity
G7048_RS16385	COG0243	molybdopterin cofactor binding
G7048_RS16405	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
G7048_RS16425	COG1953	Uracil, thiamine, allantoin
G7048_RS16435	COG0493	'glutamate synthase
G7048_RS16440	COG1309	transcriptional regulator
G7048_RS16460	COG1113	amino acid transport
G7048_RS16470	COG1280	lysine exporter protein (LysE YggA)
G7048_RS16480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G7048_RS16485	COG0724	RNA recognition motif
G7048_RS16490	COG1335	isochorismatase
G7048_RS16495	COG0583	DNA-binding transcription factor activity
G7048_RS16505	COG3276	selenocysteine insertion sequence binding
G7048_RS16510	COG1921	L-seryl-tRNASec selenium transferase activity
G7048_RS16520	COG2864	formate dehydrogenase
G7048_RS16525	COG0437	4 iron, 4 sulfur cluster binding
G7048_RS16535	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G7048_RS16540	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G7048_RS16555	COG0737	Belongs to the 5'-nucleotidase family
G7048_RS16570	COG2003	Belongs to the UPF0758 family
G7048_RS16580	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G7048_RS16585	COG1253	flavin adenine dinucleotide binding
G7048_RS16590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G7048_RS16595	COG3339	Conserved Protein
G7048_RS16600	COG2204	response regulator
G7048_RS16605	COG2205	protein histidine kinase activity
G7048_RS16620	COG0463	Glycosyl transferase, family 2
G7048_RS16640	COG1741	Belongs to the pirin family
G7048_RS16645	COG3585	molybdate ion transport
G7048_RS16655	COG0405	Gamma-glutamyltransferase
G7048_RS16665	COG1234	tRNA 3'-trailer cleavage
G7048_RS16675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7048_RS16680	COG1301	dicarboxylic acid transport
G7048_RS16690	COG0583	DNA-binding transcription factor activity
G7048_RS16695	COG2080	2 iron, 2 sulfur cluster binding
G7048_RS16700	COG2010	Cytochrome c
G7048_RS16700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G7048_RS16705	COG2010	Cytochrome c
G7048_RS16705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G7048_RS16725	COG2199	diguanylate cyclase activity
G7048_RS16730	COG1032	radical SAM domain protein
G7048_RS16735	COG0252	asparaginase activity
G7048_RS16750	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS16755	COG3119	arylsulfatase activity
G7048_RS16760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G7048_RS16765	COG0531	amino acid
G7048_RS16775	COG2205	protein histidine kinase activity
G7048_RS16780	COG0745	RESPONSE REGULATOR receiver
G7048_RS16795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7048_RS16800	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G7048_RS16805	COG4521	taurine ABC transporter
G7048_RS16810	COG2175	clavaminate synthase activity
G7048_RS16835	COG4774	siderophore transport
G7048_RS16885	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G7048_RS16890	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS16905	COG1414	Transcriptional regulator
G7048_RS16920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7048_RS16925	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G7048_RS16930	COG4521	taurine ABC transporter
G7048_RS16945	COG1113	amino acid transport
G7048_RS16950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7048_RS16960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G7048_RS16970	COG3243	poly(R)-hydroxyalkanoic acid synthase
G7048_RS16975	COG5002	protein histidine kinase activity
G7048_RS16985	COG0745	RESPONSE REGULATOR receiver
G7048_RS16990	COG0180	Tryptophanyl-tRNA synthetase
G7048_RS16995	COG1994	Peptidase M50
G7048_RS17000	COG0009	L-threonylcarbamoyladenylate synthase
G7048_RS17005	COG0613	PHP domain protein
G7048_RS17015	COG0583	DNA-binding transcription factor activity
G7048_RS17020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G7048_RS17030	COG4591	ABC-type transport system involved in lipoprotein release permease component
G7048_RS17035	COG1136	(ABC) transporter
G7048_RS17040	COG2304	oxidoreductase activity
G7048_RS17050	COG0714	Associated with various cellular activities
G7048_RS17055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7048_RS17060	COG0084	hydrolase, TatD family'
G7048_RS17070	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G7048_RS17075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G7048_RS17090	COG0697	spore germination
G7048_RS17095	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS17105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G7048_RS17130	COG0412	Dienelactone hydrolase
G7048_RS17145	COG3275	phosphorelay sensor kinase activity
G7048_RS17150	COG0165	Argininosuccinate lyase
G7048_RS17180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G7048_RS17190	COG1304	FMN binding
G7048_RS17200	COG1309	transcriptional regulator
G7048_RS17215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G7048_RS17220	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G7048_RS17220	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G7048_RS17230	COG3022	response to hydroperoxide
G7048_RS17235	COG1530	ribonuclease E activity
G7048_RS17245	COG3344	reverse transcriptase
G7048_RS17265	COG0616	signal peptide processing
G7048_RS17265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G7048_RS17270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G7048_RS17275	COG0424	maF-like protein
G7048_RS17280	COG1399	metal-binding, possibly nucleic acid-binding protein
G7048_RS17285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G7048_RS17290	COG0416	fatty acid biosynthetic process
G7048_RS17295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G7048_RS17305	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS17310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G7048_RS17315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G7048_RS17340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7048_RS17345	COG0481	GTPase activity
G7048_RS17350	COG0681	Belongs to the peptidase S26 family
G7048_RS17360	COG0571	ribonuclease III activity
G7048_RS17365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G7048_RS17370	COG1381	Involved in DNA repair and RecF pathway recombination
G7048_RS17375	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G7048_RS17380	COG0736	holo-[acyl-carrier-protein] synthase activity
G7048_RS17385	COG1472	Belongs to the glycosyl hydrolase 3 family
G7048_RS17390	COG0583	DNA-binding transcription factor activity
G7048_RS17400	COG4178	(ABC) transporter
G7048_RS17420	COG0745	RESPONSE REGULATOR receiver
G7048_RS17425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G7048_RS17440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G7048_RS17445	COG1215	transferase activity, transferring glycosyl groups
G7048_RS17455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G7048_RS17460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G7048_RS17475	COG0762	integral membrane protein
G7048_RS17480	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G7048_RS17485	COG0159	tryptophan synthase activity
G7048_RS17490	COG0133	tryptophan synthase activity
G7048_RS17495	COG0135	phosphoribosylanthranilate isomerase activity
G7048_RS17500	COG0101	tRNA pseudouridine synthase activity
G7048_RS17510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G7048_RS17520	COG0473	3-isopropylmalate dehydrogenase activity
G7048_RS17525	COG0066	3-isopropylmalate dehydratase activity
G7048_RS17535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G7048_RS17550	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G7048_RS17565	COG3154	lipid carrier protein
G7048_RS17570	COG0826	peptidase U32
G7048_RS17575	COG0826	peptidase U32
G7048_RS17580	COG0484	heat shock protein binding
G7048_RS17585	COG0443	Heat shock 70 kDa protein
G7048_RS17590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G7048_RS17595	COG0360	Binds together with S18 to 16S ribosomal RNA
G7048_RS17600	COG2965	DNA replication, synthesis of RNA primer
G7048_RS17605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G7048_RS17610	COG0359	binds to the 23S rRNA
G7048_RS17615	COG0305	Participates in initiation and elongation during chromosome replication
G7048_RS17630	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G7048_RS17635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G7048_RS17645	COG0436	Aminotransferase
G7048_RS17660	COG1763	Mo-molybdopterin cofactor biosynthetic process
G7048_RS17665	COG0303	'Molybdopterin
G7048_RS17670	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G7048_RS17700	COG0314	molybdopterin synthase activity
G7048_RS17710	COG0542	response to heat
G7048_RS17735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G7048_RS17775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7048_RS17780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7048_RS17805	COG0765	amino acid transport
G7048_RS17810	COG1126	abc transporter atp-binding protein
G7048_RS17820	COG0511	ligase activity, forming carbon-carbon bonds
G7048_RS17830	COG1984	allophanate hydrolase subunit 2
G7048_RS17835	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G7048_RS17840	COG0511	ligase activity, forming carbon-carbon bonds
G7048_RS17845	COG0439	Biotin carboxylase
G7048_RS17945	COG1802	Transcriptional regulator
G7048_RS17960	COG3038	cytochrome b561
G7048_RS17965	COG2353	YceI-like domain
G7048_RS17995	COG1289	transmembrane transporter activity
G7048_RS18005	COG1960	acyl-CoA dehydrogenase activity
G7048_RS18015	COG0280	phosphate acetyltransferase
G7048_RS18015	COG0281	malic enzyme
G7048_RS18020	COG2233	PERMEase
G7048_RS18035	COG2814	Major facilitator Superfamily
G7048_RS18040	COG0583	DNA-binding transcription factor activity
G7048_RS18055	COG2159	amidohydrolase
G7048_RS18080	COG2186	Transcriptional regulator
G7048_RS18105	COG0402	S-adenosylhomocysteine deaminase activity
G7048_RS18110	COG0717	Belongs to the dCTP deaminase family
G7048_RS18115	COG2321	neutral zinc metallopeptidase
G7048_RS18120	COG0513	Belongs to the DEAD box helicase family
G7048_RS18125	COG2329	Antibiotic biosynthesis monooxygenase
G7048_RS18130	COG4585	Histidine kinase
G7048_RS18140	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
G7048_RS18155	COG2308	Evidence 4 Homologs of previously reported genes of
G7048_RS18195	COG1722	exodeoxyribonuclease VII activity
G7048_RS18200	COG0142	geranyltranstransferase activity
G7048_RS18205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G7048_RS18210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G7048_RS18235	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G7048_RS18310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G7048_RS18320	COG1215	transferase activity, transferring glycosyl groups
G7048_RS18330	COG0537	adenosine 5'-monophosphoramidase activity
G7048_RS18345	COG0251	oxidation-reduction process
G7048_RS18360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7048_RS18370	COG3447	MASE1 domain protein
G7048_RS18370	COG5001	Diguanylate cyclase
G7048_RS18370	COG5002	protein histidine kinase activity
G7048_RS18375	COG2814	Major facilitator Superfamily
G7048_RS18380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G7048_RS18395	COG1129	ABC transporter
G7048_RS18420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7048_RS18425	COG1126	abc transporter atp-binding protein
G7048_RS18435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7048_RS18455	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G7048_RS18460	COG3483	tryptophan 2,3-dioxygenase activity
G7048_RS18475	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G7048_RS18480	COG0727	PFAM Uncharacterised protein family (UPF0153)
G7048_RS18505	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7048_RS18530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G7048_RS18535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G7048_RS18550	COG0268	Binds directly to 16S ribosomal RNA
G7048_RS18555	COG0728	peptidoglycan biosynthetic process
G7048_RS18560	COG2912	Transglutaminase-like superfamily
G7048_RS18570	COG0589	response to stress
G7048_RS18580	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G7048_RS18585	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G7048_RS18590	COG2217	Heavy metal translocating P-type atpase
G7048_RS18595	COG0617	tRNA 3'-terminal CCA addition
G7048_RS18615	COG0543	2 iron, 2 sulfur cluster binding
G7048_RS18615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G7048_RS18635	COG0583	DNA-binding transcription factor activity
G7048_RS18640	COG2910	NAD(P)H-binding
G7048_RS18670	COG1960	acyl-CoA dehydrogenase activity
G7048_RS18675	COG0583	DNA-binding transcription factor activity
G7048_RS18690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7048_RS18710	COG0745	RESPONSE REGULATOR receiver
G7048_RS18715	COG2205	protein histidine kinase activity
G7048_RS18720	COG2113	Glycine betaine
G7048_RS18725	COG4176	ABC-type proline glycine betaine transport system permease component
G7048_RS18730	COG4175	Glycine betaine
G7048_RS18740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS18760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G7048_RS18770	COG4654	Cytochrome c, class I
G7048_RS18780	COG0129	dihydroxy-acid dehydratase activity
G7048_RS18800	COG2124	cytochrome p450
G7048_RS18820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G7048_RS18830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G7048_RS18835	COG1840	ABC-type Fe3 transport system, periplasmic component
G7048_RS18840	COG1178	ABC-type Fe3 transport system permease component
G7048_RS18845	COG3842	ATPase activity
G7048_RS18850	COG0583	DNA-binding transcription factor activity
G7048_RS18855	COG0560	Phosphoserine phosphatase
G7048_RS18865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7048_RS18870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G7048_RS18885	COG2814	Major facilitator Superfamily
G7048_RS18895	COG0544	peptidyl-prolyl cis-trans isomerase activity
G7048_RS18900	COG0740	serine-type endopeptidase activity
G7048_RS18905	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G7048_RS18910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G7048_RS18945	COG1451	nucleotide metabolic process
G7048_RS18950	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G7048_RS18980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G7048_RS19010	COG0114	fumarate hydratase activity
G7048_RS19035	COG0765	amino acid transport
G7048_RS19060	COG0778	Nitroreductase
G7048_RS19125	COG0629	single-stranded DNA binding
G7048_RS19245	COG0358	DNA primase activity
G7048_RS19330	COG0740	serine-type endopeptidase activity
G7048_RS19430	COG0582	viral genome integration into host DNA
G7048_RS19450	COG0425	Belongs to the sulfur carrier protein TusA family
G7048_RS19455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7048_RS19460	COG0697	spore germination
G7048_RS19465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G7048_RS19470	COG0525	valine-tRNA ligase activity
G7048_RS19480	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS19485	COG0604	alcohol dehydrogenase
G7048_RS19490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS19495	COG0583	DNA-binding transcription factor activity
G7048_RS19545	COG0181	hydroxymethylbilane synthase activity
G7048_RS19550	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G7048_RS19555	COG1289	transmembrane transporter activity
G7048_RS19570	COG0450	alkyl hydroperoxide reductase
G7048_RS19575	COG3634	alkyl hydroperoxide reductase activity
G7048_RS19595	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G7048_RS19610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G7048_RS19630	COG0583	DNA-binding transcription factor activity
G7048_RS19645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G7048_RS19655	COG3384	dioxygenase
G7048_RS19680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G7048_RS19685	COG0358	DNA primase activity
G7048_RS19690	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS19710	COG0179	Fumarylacetoacetate (FAA) hydrolase
G7048_RS19725	COG2814	Major facilitator Superfamily
G7048_RS19730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G7048_RS19740	COG0405	Gamma-glutamyltransferase
G7048_RS19745	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G7048_RS19745	COG3608	succinylglutamate desuccinylase aspartoacylase
G7048_RS19760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G7048_RS19790	COG2346	COG2346, Truncated hemoglobins
G7048_RS19810	COG1045	serine acetyltransferase
G7048_RS19825	COG0477	Major facilitator Superfamily
G7048_RS19830	COG0584	glycerophosphoryl diester phosphodiesterase
G7048_RS19835	COG0521	Mo-molybdopterin cofactor biosynthetic process
G7048_RS19845	COG0312	modulator of DNA gyrase
G7048_RS19855	COG0745	RESPONSE REGULATOR receiver
G7048_RS19860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G7048_RS19870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7048_RS19875	COG4521	taurine ABC transporter
G7048_RS19880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G7048_RS19900	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7048_RS19925	COG0473	3-isopropylmalate dehydrogenase activity
G7048_RS19930	COG0583	DNA-binding transcription factor activity
G7048_RS19940	COG1522	sequence-specific DNA binding
G7048_RS19950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G7048_RS19965	COG2081	HI0933 family
G7048_RS19975	COG1607	acyl-coa hydrolase
G7048_RS20000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G7048_RS20015	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
G7048_RS20020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G7048_RS20030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G7048_RS20040	COG0583	DNA-binding transcription factor activity
G7048_RS20045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS20050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G7048_RS20075	COG0776	regulation of translation
G7048_RS20080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G7048_RS20085	COG0322	excinuclease ABC activity
G7048_RS20105	COG2186	Transcriptional regulator
G7048_RS20115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G7048_RS20130	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
G7048_RS20145	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
G7048_RS20150	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
G7048_RS20155	COG0298	carbon dioxide binding
G7048_RS20160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7048_RS20165	COG1773	rubredoxin
G7048_RS20170	COG1773	rubredoxin
G7048_RS20175	COG1773	rubredoxin
G7048_RS20180	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
G7048_RS20185	COG0375	protein maturation
G7048_RS20190	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G7048_RS20195	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
G7048_RS20200	COG0298	carbon dioxide binding
G7048_RS20205	COG0409	Hydrogenase expression formation protein
G7048_RS20210	COG0309	Hydrogenase expression formation protein (HypE)
G7048_RS20215	COG2204	response regulator
G7048_RS20250	COG0411	ABC transporter
G7048_RS20280	COG0513	Belongs to the DEAD box helicase family
G7048_RS20285	COG0488	(ABC) transporter
G7048_RS20300	COG3191	aminopeptidase activity
G7048_RS20335	COG2132	Multicopper oxidase
G7048_RS20390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G7048_RS20395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7048_RS20400	COG0052	Belongs to the universal ribosomal protein uS2 family
G7048_RS20405	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G7048_RS20410	COG0528	UMP kinase activity
G7048_RS20415	COG0233	cytoplasmic translational termination
G7048_RS20420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G7048_RS20425	COG0575	Belongs to the CDS family
G7048_RS20430	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G7048_RS20435	COG0750	zinc metalloprotease
G7048_RS20450	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7048_RS20455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G7048_RS20460	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7048_RS20465	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7048_RS20470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G7048_RS20475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G7048_RS20480	COG2814	Major facilitator Superfamily
G7048_RS20485	COG1566	PFAM secretion protein HlyD family protein
G7048_RS20530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7048_RS20535	COG0642	Histidine kinase
G7048_RS20585	COG4654	Cytochrome c, class I
G7048_RS20590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G7048_RS20595	COG4654	Cytochrome c, class I
G7048_RS20620	COG0737	Belongs to the 5'-nucleotidase family
G7048_RS20625	COG2391	methyltransferase activity
G7048_RS20640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G7048_RS20685	COG0625	glutathione transferase activity
G7048_RS20690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G7048_RS20695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G7048_RS20700	COG1011	Hydrolase
G7048_RS20715	COG2267	carboxylic ester hydrolase activity
G7048_RS20720	COG0456	acetyltransferase
G7048_RS20730	COG0517	IMP dehydrogenase activity
G7048_RS20730	COG1125	glycine betaine transport
G7048_RS20735	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G7048_RS20740	COG0372	Belongs to the citrate synthase family
G7048_RS20745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS20750	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G7048_RS20770	COG0183	Belongs to the thiolase family
G7048_RS20795	COG2197	response regulator
G7048_RS20805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G7048_RS20810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G7048_RS20815	COG0741	lytic transglycosylase activity
G7048_RS20835	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS20840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G7048_RS20850	COG4969	Belongs to the N-Me-Phe pilin family
G7048_RS20880	COG2807	transmembrane transport
G7048_RS20935	COG2153	protein acetylation
G7048_RS20950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G7048_RS20960	COG2814	Major facilitator Superfamily
G7048_RS20965	COG2423	ornithine cyclodeaminase activity
G7048_RS20970	COG1522	sequence-specific DNA binding
G7048_RS20975	COG3706	GGDEF domain
G7048_RS20995	COG2183	response to ionizing radiation
G7048_RS21040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G7048_RS21045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G7048_RS21050	COG0470	DNA polymerase III
G7048_RS21060	COG0084	hydrolase, TatD family'
G7048_RS21070	COG1132	(ABC) transporter
G7048_RS21075	COG0823	Involved in the tonB-independent uptake of proteins
G7048_RS21090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G7048_RS21100	COG0438	transferase activity, transferring glycosyl groups
G7048_RS21120	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G7048_RS21130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7048_RS21140	COG1733	regulation of RNA biosynthetic process
G7048_RS21145	COG0655	NAD(P)H dehydrogenase (quinone) activity
G7048_RS21150	COG1090	epimerase
G7048_RS21160	COG5000	phosphorelay sensor kinase activity
G7048_RS21165	COG2204	response regulator
G7048_RS21170	COG2814	Major facilitator Superfamily
G7048_RS21190	COG1643	Atp-dependent helicase
G7048_RS21195	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G7048_RS21210	COG0583	DNA-binding transcription factor activity
G7048_RS21215	COG0656	L-ascorbic acid biosynthetic process
G7048_RS21240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G7048_RS21245	COG0252	asparaginase activity
G7048_RS21250	COG0563	adenylate kinase activity
G7048_RS21255	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G7048_RS21260	COG2835	tetraacyldisaccharide 4'-kinase activity
G7048_RS21265	COG1663	tetraacyldisaccharide 4'-kinase activity
G7048_RS21270	COG0848	biopolymer transport protein
G7048_RS21275	COG0811	peptide transport
G7048_RS21280	COG1570	exodeoxyribonuclease VII activity
G7048_RS21285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G7048_RS21295	COG0583	DNA-binding transcription factor activity
G7048_RS21355	COG2832	Protein of unknown function (DUF454)
G7048_RS21360	COG0242	peptide deformylase activity
G7048_RS21365	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G7048_RS21370	COG0024	Methionine aminopeptidase
G7048_RS21380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G7048_RS21380	COG0047	phosphoribosylformylglycinamidine synthase activity
G7048_RS21385	COG2354	Protein conserved in bacteria
G7048_RS21390	COG3047	cAMP biosynthetic process
G7048_RS21400	COG0410	ABC transporter
G7048_RS21410	COG4177	L-phenylalanine transmembrane transporter activity
G7048_RS21455	COG0826	peptidase U32
G7048_RS21470	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
G7048_RS21490	COG1397	ADP-ribosylglycohydrolase
G7048_RS21505	COG1619	proteins homologs of microcin C7 resistance protein MccF
G7048_RS21515	COG0583	DNA-binding transcription factor activity
G7048_RS21535	COG0217	transcriptional regulatory protein
G7048_RS21560	COG1741	Belongs to the pirin family
G7048_RS21570	COG0659	secondary active sulfate transmembrane transporter activity
G7048_RS21575	COG2823	Periplasmic or secreted lipoprotein
G7048_RS21590	COG4181	ATPase activity
G7048_RS21595	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
G7048_RS21610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G7048_RS21615	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G7048_RS21675	COG3550	peptidyl-serine autophosphorylation
G7048_RS21690	COG1739	Uncharacterized protein family UPF0029
G7048_RS21720	COG1278	Cold shock
G7048_RS21725	COG3384	dioxygenase
G7048_RS21735	COG0556	nucleotide-excision repair
G7048_RS21740	COG1959	2 iron, 2 sulfur cluster binding
G7048_RS21745	COG1104	cysteine desulfurase activity
G7048_RS21750	COG0822	iron-sulfur transferase activity
G7048_RS21755	COG0316	Belongs to the HesB IscA family
G7048_RS21760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G7048_RS21765	COG0443	Heat shock 70 kDa protein
G7048_RS21775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G7048_RS21795	COG1116	anion transmembrane transporter activity
G7048_RS21800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7048_RS21810	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS21835	COG1024	Enoyl-CoA hydratase
G7048_RS21840	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS21850	COG1960	acyl-CoA dehydrogenase activity
G7048_RS21865	COG1960	acyl-CoA dehydrogenase activity
G7048_RS21880	COG1960	acyl-CoA dehydrogenase activity
G7048_RS21890	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS21910	COG0745	RESPONSE REGULATOR receiver
G7048_RS21915	COG2205	protein histidine kinase activity
G7048_RS21920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7048_RS21925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G7048_RS21955	COG2099	Precorrin-6x reductase
G7048_RS21970	COG2875	Belongs to the precorrin methyltransferase family
G7048_RS21980	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS21985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7048_RS21995	COG1414	Transcriptional regulator
G7048_RS22020	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS22035	COG0583	DNA-binding transcription factor activity
G7048_RS22110	COG1136	(ABC) transporter
G7048_RS22110	COG0577	efflux transmembrane transporter activity
G7048_RS22115	COG1538	Outer membrane efflux protein
G7048_RS22150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS22155	COG0583	DNA-binding transcription factor activity
G7048_RS22165	COG1960	acyl-CoA dehydrogenase activity
G7048_RS22185	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G7048_RS22190	COG2234	aminopeptidase activity
G7048_RS22205	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS22210	COG1024	Enoyl-CoA hydratase
G7048_RS22215	COG2030	dehydratase
G7048_RS22220	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS22225	COG0579	oxidoreductase
G7048_RS22245	COG0167	dihydroorotate dehydrogenase activity
G7048_RS22250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G7048_RS22265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G7048_RS22270	COG4566	intracellular signal transduction
G7048_RS22285	COG0508	dehydrogenase complex catalyzes the overall conversion of
G7048_RS22290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G7048_RS22310	COG2951	lytic endotransglycosylase activity
G7048_RS22315	COG2925	Exonuclease
G7048_RS22325	COG0628	permease
G7048_RS22335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G7048_RS22345	COG0625	glutathione transferase activity
G7048_RS22355	COG0583	DNA-binding transcription factor activity
G7048_RS22360	COG0433	COG0433 Predicted ATPase
G7048_RS22365	COG0217	transcriptional regulatory protein
G7048_RS22370	COG0151	Belongs to the GarS family
G7048_RS22375	COG0408	coproporphyrinogen oxidase activity
G7048_RS22380	COG0799	negative regulation of ribosome biogenesis
G7048_RS22385	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G7048_RS22390	COG0424	maF-like protein
G7048_RS22405	COG0714	Associated with various cellular activities
G7048_RS22410	COG3256	nitric oxide reductase
G7048_RS22415	COG2010	Cytochrome c
G7048_RS22425	COG1845	cytochrome c oxidase, subunit III
G7048_RS22435	COG0641	radical SAM
G7048_RS22455	COG3391	amine dehydrogenase activity
G7048_RS22460	COG2010	Cytochrome c
G7048_RS22470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G7048_RS22470	COG1648	precorrin-2 dehydrogenase activity
G7048_RS22475	COG1530	ribonuclease E activity
G7048_RS22480	COG0583	DNA-binding transcription factor activity
G7048_RS22485	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
G7048_RS22490	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G7048_RS22505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G7048_RS22515	COG0436	Aminotransferase
G7048_RS22520	COG0583	DNA-binding transcription factor activity
G7048_RS22540	COG1477	protein flavinylation
G7048_RS22545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G7048_RS22565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G7048_RS22585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7048_RS22635	COG2974	May be involved in recombination
G7048_RS22650	COG3723	Recombinational DNA repair protein, rece pathway
G7048_RS22710	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
G7048_RS22740	COG0582	viral genome integration into host DNA
G7048_RS22775	COG1982	Orn Lys Arg decarboxylase major
G7048_RS22785	COG1793	dna ligase
G7048_RS22790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS22795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G7048_RS22800	COG1414	Transcriptional regulator
G7048_RS22805	COG0513	Belongs to the DEAD box helicase family
G7048_RS22835	COG4166	transmembrane transport
G7048_RS22840	COG4174	ABC transporter (Permease)
G7048_RS22850	COG4239	(ABC) transporter, permease
G7048_RS22855	COG4172	Belongs to the ABC transporter superfamily
G7048_RS22860	COG0596	Alpha beta hydrolase
G7048_RS22865	COG0589	response to stress
G7048_RS22870	COG0583	DNA-binding transcription factor activity
G7048_RS22885	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS22890	COG0628	permease
G7048_RS22895	COG0567	Dehydrogenase, E1 component
G7048_RS22900	COG0508	dehydrogenase complex catalyzes the overall conversion of
G7048_RS22905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G7048_RS22910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G7048_RS22925	COG1199	ATP-dependent helicase activity
G7048_RS22940	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G7048_RS22945	COG0542	response to heat
G7048_RS22965	COG0587	DNA-directed DNA polymerase activity
G7048_RS22990	COG1960	acyl-CoA dehydrogenase activity
G7048_RS23005	COG0596	Alpha beta hydrolase
G7048_RS23010	COG0583	DNA-binding transcription factor activity
G7048_RS23045	COG2197	response regulator
G7048_RS23050	COG4585	Histidine kinase
G7048_RS23060	COG2982	Protein involved in outer membrane biogenesis
G7048_RS23070	COG0564	pseudouridine synthase activity
G7048_RS23140	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
G7048_RS23155	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS23160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G7048_RS23185	COG0583	DNA-binding transcription factor activity
G7048_RS23200	COG3706	GGDEF domain
G7048_RS23205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G7048_RS23210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G7048_RS23215	COG1233	COG1233 Phytoene dehydrogenase and related
G7048_RS23220	COG0583	DNA-binding transcription factor activity
G7048_RS23225	COG1741	Belongs to the pirin family
G7048_RS23235	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G7048_RS23240	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G7048_RS23250	COG3171	Protein conserved in bacteria
G7048_RS23295	COG1960	acyl-CoA dehydrogenase activity
G7048_RS23310	COG0583	DNA-binding transcription factor activity
G7048_RS23315	COG1113	amino acid transport
G7048_RS23320	COG2337	Toxic component of a toxin-antitoxin (TA) module
G7048_RS23330	COG2814	Major facilitator Superfamily
G7048_RS23335	COG1132	(ABC) transporter
G7048_RS23350	COG1742	UPF0060 membrane protein
G7048_RS23355	COG1196	nuclear chromosome segregation
G7048_RS23365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G7048_RS23380	COG0179	Fumarylacetoacetate (FAA) hydrolase
G7048_RS23400	COG3243	poly(R)-hydroxyalkanoic acid synthase
G7048_RS23405	COG0183	Belongs to the thiolase family
G7048_RS23410	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS23415	COG0488	(ABC) transporter
G7048_RS23425	COG2890	protein-(glutamine-N5) methyltransferase activity
G7048_RS23430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7048_RS23440	COG2171	N-acyltransferase activity
G7048_RS23450	COG2878	Part of a membrane complex involved in electron transport
G7048_RS23475	COG1022	Amp-dependent synthetase and ligase
G7048_RS23480	COG1802	Transcriptional regulator
G7048_RS23485	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G7048_RS23485	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G7048_RS23490	COG1703	isobutyryl-CoA mutase activity
G7048_RS23495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G7048_RS23500	COG4770	biotin carboxylase activity
G7048_RS23535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS23540	COG1024	Enoyl-CoA hydratase
G7048_RS23540	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7048_RS23545	COG0730	response to heat
G7048_RS23565	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G7048_RS23580	COG3384	dioxygenase
G7048_RS23585	COG2388	GCN5-related N-acetyl-transferase
G7048_RS23680	COG2885	chlorophyll binding
G7048_RS23705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G7048_RS23755	COG2894	cell division
G7048_RS23790	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS23795	COG0346	lactoylglutathione lyase activity
G7048_RS23800	COG0800	Aldolase
G7048_RS23810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G7048_RS23815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G7048_RS23820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
G7048_RS23825	COG3265	gluconokinase activity
G7048_RS23860	COG2032	superoxide dismutase activity
G7048_RS23865	COG0259	pyridoxamine-phosphate oxidase activity
G7048_RS23890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G7048_RS23895	COG1309	transcriptional regulator
G7048_RS23900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G7048_RS23915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G7048_RS23915	COG1042	CoA-binding domain protein
G7048_RS23915	COG0045	succinate-CoA ligase (ADP-forming) activity
G7048_RS23930	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G7048_RS23965	COG2133	pyrroloquinoline quinone binding
G7048_RS23970	COG0791	NLP P60 protein
G7048_RS23985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G7048_RS24000	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS24035	COG0501	Belongs to the peptidase M48B family
G7048_RS24045	COG0501	Belongs to the peptidase M48B family
G7048_RS24070	COG1252	NADH dehydrogenase
G7048_RS24105	COG0642	Histidine kinase
G7048_RS24115	COG1574	metal-dependent hydrolase with the TIM-barrel fold
G7048_RS24130	COG4120	Belongs to the binding-protein-dependent transport system permease family
G7048_RS24135	COG1122	ATPase activity
G7048_RS24140	COG0833	amino acid
G7048_RS24150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G7048_RS24165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G7048_RS24170	COG0509	glycine decarboxylation via glycine cleavage system
G7048_RS24175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G7048_RS24175	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G7048_RS24180	COG0564	pseudouridine synthase activity
G7048_RS24190	COG0559	Belongs to the binding-protein-dependent transport system permease family
G7048_RS24210	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS24215	COG0183	Belongs to the thiolase family
G7048_RS24225	COG2703	oxygen carrier activity
G7048_RS24230	COG0589	response to stress
G7048_RS24290	COG2197	response regulator
G7048_RS24320	COG2205	protein histidine kinase activity
G7048_RS24355	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS24425	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS24430	COG3246	L-lysine catabolic process to acetate
G7048_RS24450	COG1609	Transcriptional regulator
G7048_RS24490	COG3833	ABC-type maltose transport systems, permease component
G7048_RS24495	COG3842	ATPase activity
G7048_RS24525	COG4774	siderophore transport
G7048_RS24530	COG3128	pkhd-type hydroxylase
G7048_RS24540	COG1902	pentaerythritol trinitrate reductase activity
G7048_RS24555	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS24585	COG1960	acyl-CoA dehydrogenase activity
G7048_RS24590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G7048_RS24605	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS24615	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS24635	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G7048_RS24640	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G7048_RS24650	COG0183	Belongs to the thiolase family
G7048_RS24660	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS24670	COG1960	acyl-CoA dehydrogenase activity
G7048_RS24675	COG1960	acyl-CoA dehydrogenase activity
G7048_RS24680	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS24690	COG0183	Belongs to the thiolase family
G7048_RS24695	COG1960	acyl-CoA dehydrogenase activity
G7048_RS24700	COG1960	acyl-CoA dehydrogenase activity
G7048_RS24710	COG2070	2-Nitropropane dioxygenase
G7048_RS24715	COG1024	Enoyl-CoA hydratase
G7048_RS24730	COG0346	lactoylglutathione lyase activity
G7048_RS24745	COG3772	lysozyme
G7048_RS24850	COG2755	lipolytic protein G-D-S-L family
G7048_RS24850	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G7048_RS24855	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G7048_RS24855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G7048_RS24875	COG0251	oxidation-reduction process
G7048_RS24880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7048_RS24895	COG1770	oligopeptidase
G7048_RS24920	COG3712	iron ion homeostasis
G7048_RS24925	COG1595	DNA-templated transcription, initiation
G7048_RS24930	COG4774	siderophore transport
G7048_RS24935	COG3712	iron ion homeostasis
G7048_RS24945	COG1595	DNA-templated transcription, initiation
G7048_RS24950	COG3712	iron ion homeostasis
G7048_RS24955	COG4773	Receptor
G7048_RS24985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7048_RS24990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7048_RS25000	COG2828	Protein conserved in bacteria
G7048_RS25020	COG3800	Transcriptional regulator
G7048_RS25020	COG1396	sequence-specific DNA binding
G7048_RS25035	COG3128	pkhd-type hydroxylase
G7048_RS25050	COG1120	ATPase activity
G7048_RS25055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G7048_RS25060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G7048_RS25070	COG4774	siderophore transport
G7048_RS25075	COG4607	ABC-type enterochelin transport system periplasmic component
G7048_RS25080	COG4604	ABC transporter, ATP-binding protein
G7048_RS25085	COG4605	iron ion homeostasis
G7048_RS25090	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G7048_RS25110	COG4772	TonB-dependent receptor
G7048_RS25125	COG0598	Magnesium transport protein CorA
G7048_RS25135	COG0789	Transcriptional regulator
G7048_RS25155	COG3618	amidohydrolase
G7048_RS25175	COG0559	Belongs to the binding-protein-dependent transport system permease family
G7048_RS25185	COG0583	DNA-binding transcription factor activity
G7048_RS25215	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS25245	COG4206	TonB-dependent receptor
G7048_RS25260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G7048_RS25265	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G7048_RS25280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7048_RS25300	COG0431	NADPH-dependent FMN reductase
G7048_RS25305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7048_RS25325	COG1216	Glycosyl transferase, family 2
G7048_RS25345	COG2186	Transcriptional regulator
G7048_RS25350	COG0778	Nitroreductase
G7048_RS25365	COG0346	lactoylglutathione lyase activity
G7048_RS25390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7048_RS25405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G7048_RS25430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7048_RS25440	COG4120	Belongs to the binding-protein-dependent transport system permease family
G7048_RS25455	COG1802	Transcriptional regulator
G7048_RS25460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G7048_RS25465	COG0583	DNA-binding transcription factor activity
G7048_RS25470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G7048_RS25505	COG1917	Cupin 2, conserved barrel domain protein
G7048_RS25520	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS25525	COG4946	Tricorn protease homolog
G7048_RS25525	COG1506	peptidase
G7048_RS25525	COG0823	Involved in the tonB-independent uptake of proteins
G7048_RS25565	COG0028	Belongs to the TPP enzyme family
G7048_RS25575	COG3384	dioxygenase
G7048_RS25580	COG2271	Major facilitator Superfamily
G7048_RS25585	COG3618	amidohydrolase
G7048_RS25590	COG2159	amidohydrolase
G7048_RS25615	COG0583	DNA-binding transcription factor activity
G7048_RS25625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G7048_RS25635	COG1454	alcohol dehydrogenase
G7048_RS25655	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS25655	COG2030	dehydratase
G7048_RS25660	COG1960	acyl-CoA dehydrogenase activity
G7048_RS25665	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS25685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS25690	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS25695	COG1024	Enoyl-CoA hydratase
G7048_RS25710	COG0583	DNA-binding transcription factor activity
G7048_RS25760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS25765	COG1960	acyl-CoA dehydrogenase activity
G7048_RS25785	COG0625	glutathione transferase activity
G7048_RS25800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS25815	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS25830	COG1473	amidohydrolase
G7048_RS25840	COG0028	Belongs to the TPP enzyme family
G7048_RS25845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7048_RS25860	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS25870	COG0625	glutathione transferase activity
G7048_RS25900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7048_RS25905	COG2897	thiosulfate sulfurtransferase activity
G7048_RS25935	COG1414	Transcriptional regulator
G7048_RS25945	COG1192	Involved in chromosome partitioning
G7048_RS25950	COG1475	DNA binding
G7048_RS25955	COG4974	Belongs to the 'phage' integrase family
G7048_RS25995	COG3971	2-oxopent-4-enoate hydratase activity
G7048_RS26000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G7048_RS26035	COG0179	Fumarylacetoacetate (FAA) hydrolase
G7048_RS26045	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS26050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7048_RS26065	COG1309	transcriptional regulator
G7048_RS26075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS26095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G7048_RS26110	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7048_RS26145	COG2030	dehydratase
G7048_RS26150	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS26155	COG0427	acetyl-CoA hydrolase
G7048_RS26180	COG1960	acyl-CoA dehydrogenase activity
G7048_RS26185	COG1960	acyl-CoA dehydrogenase activity
G7048_RS26190	COG2301	Belongs to the HpcH HpaI aldolase family
G7048_RS26195	COG1960	acyl-CoA dehydrogenase activity
G7048_RS26200	COG3246	L-lysine catabolic process to acetate
G7048_RS26240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G7048_RS26245	COG0022	dehydrogenase e1 component
G7048_RS26250	COG0511	ligase activity, forming carbon-carbon bonds
G7048_RS26255	COG0508	dehydrogenase complex catalyzes the overall conversion of
G7048_RS26315	COG1024	Enoyl-CoA hydratase
G7048_RS26320	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS26345	COG1024	Enoyl-CoA hydratase
G7048_RS26350	COG1024	Enoyl-CoA hydratase
G7048_RS26355	COG0300	oxidoreductase activity
G7048_RS26360	COG1309	transcriptional regulator
G7048_RS26380	COG1845	cytochrome c oxidase, subunit III
G7048_RS26390	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G7048_RS26395	COG2030	dehydratase
G7048_RS26400	COG2130	NADP-dependent
G7048_RS26405	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS26450	COG0574	Belongs to the PEP-utilizing enzyme family
G7048_RS26450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G7048_RS26475	COG1233	COG1233 Phytoene dehydrogenase and related
G7048_RS26510	COG0477	Major facilitator Superfamily
G7048_RS26515	COG0154	amidase activity
G7048_RS26520	COG0583	DNA-binding transcription factor activity
G7048_RS26525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G7048_RS26535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7048_RS26555	COG0583	DNA-binding transcription factor activity
G7048_RS26565	COG0473	3-isopropylmalate dehydrogenase activity
G7048_RS26565	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7048_RS26595	COG2271	Major facilitator Superfamily
G7048_RS26625	COG0559	Belongs to the binding-protein-dependent transport system permease family
G7048_RS26655	COG2267	carboxylic ester hydrolase activity
G7048_RS26660	COG2188	Transcriptional regulator
G7048_RS26665	COG1024	Enoyl-CoA hydratase
G7048_RS26665	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7048_RS26705	COG0477	Major facilitator Superfamily
G7048_RS26710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G7048_RS26715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G7048_RS26725	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS26730	COG0028	Belongs to the TPP enzyme family
G7048_RS26740	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS26745	COG0277	FAD linked oxidase domain protein
G7048_RS26755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7048_RS26775	COG2186	Transcriptional regulator
G7048_RS26780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7048_RS26785	COG4948	Mandelate Racemase Muconate Lactonizing
G7048_RS26800	COG1309	transcriptional regulator
G7048_RS26805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G7048_RS26810	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G7048_RS26820	COG1022	Amp-dependent synthetase and ligase
G7048_RS26850	COG1309	transcriptional regulator
G7048_RS26860	COG1024	Enoyl-CoA hydratase
G7048_RS26865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G7048_RS26865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G7048_RS26870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G7048_RS26870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G7048_RS26875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS26905	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS26935	COG1960	acyl-CoA dehydrogenase activity
G7048_RS26950	COG2175	clavaminate synthase activity
G7048_RS26970	COG0318	PFAM AMP-dependent synthetase and ligase
G7048_RS26975	COG4804	nuclease activity
G7048_RS26990	COG3246	L-lysine catabolic process to acetate
G7048_RS26995	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS27005	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS27010	COG3246	L-lysine catabolic process to acetate
G7048_RS27080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G7048_RS27100	COG2314	TM2 domain
G7048_RS27120	COG3048	D-serine ammonia-lyase activity
G7048_RS27125	COG0747	negative chemotaxis
G7048_RS27130	COG0601	transmembrane transport
G7048_RS27140	COG4172	Belongs to the ABC transporter superfamily
G7048_RS27150	COG0583	DNA-binding transcription factor activity
G7048_RS27175	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G7048_RS27180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G7048_RS27185	COG0439	Biotin carboxylase
G7048_RS27200	COG1028	Short-chain dehydrogenase reductase Sdr
G7048_RS27215	COG2945	thiolester hydrolase activity
G7048_RS27215	COG0596	Alpha beta hydrolase
G7048_RS27250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G7048_RS27255	COG2084	Dehydrogenase
G7048_RS27280	COG4680	protein conserved in bacteria
G7048_RS27375	COG0183	Belongs to the thiolase family
G7048_RS27380	COG2030	dehydratase
G7048_RS27390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7048_RS27395	COG1960	acyl-CoA dehydrogenase activity
G7048_RS27430	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS27435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7048_RS27445	COG1487	ribonuclease activity
G7048_RS27480	COG1304	FMN binding
G7048_RS27485	COG2721	sulfolactate sulfo-lyase activity
G7048_RS27490	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS27495	COG4948	Mandelate Racemase Muconate Lactonizing
G7048_RS27500	COG1802	Transcriptional regulator
G7048_RS27505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G7048_RS27510	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS27515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7048_RS27530	COG1012	belongs to the aldehyde dehydrogenase family
G7048_RS27535	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS27545	COG4948	Mandelate Racemase Muconate Lactonizing
G7048_RS27550	COG2186	Transcriptional regulator
G7048_RS27575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G7048_RS27590	COG1172	Belongs to the binding-protein-dependent transport system permease family
G7048_RS27595	COG1129	ABC transporter
G7048_RS27600	COG1879	ABC-type sugar transport system periplasmic component
G7048_RS27605	COG1984	allophanate hydrolase subunit 2
G7048_RS27615	COG0439	Biotin carboxylase
G7048_RS27620	COG0511	ligase activity, forming carbon-carbon bonds
G7048_RS27625	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G7048_RS27645	COG3550	peptidyl-serine autophosphorylation
G7048_RS27650	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
G7048_RS27655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G7048_RS27660	COG3135	benzoate transporter
G7048_RS27665	COG2271	Major facilitator Superfamily
G7048_RS27670	COG2814	Major facilitator Superfamily
G7048_RS27695	COG3485	protocatechuate 3,4-dioxygenase
G7048_RS27710	COG2205	protein histidine kinase activity
G7048_RS27750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G7048_RS27755	COG1053	succinate dehydrogenase
G7048_RS27760	COG0477	Major facilitator Superfamily
G7048_RS27765	COG0066	3-isopropylmalate dehydratase activity
G7048_RS27780	COG0583	DNA-binding transcription factor activity
G7048_RS27785	COG2129	metallophosphoesterase
G7048_RS27800	COG0384	phenazine biosynthesis protein PhzF
G7048_RS27810	COG1024	Enoyl-CoA hydratase
G7048_RS27830	COG0765	amino acid transport
G7048_RS27835	COG0765	amino acid transport
G7048_RS27870	COG0417	DNA replication proofreading
G7048_RS27875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G7048_RS27885	COG0303	'Molybdopterin
G7048_RS27905	COG0746	molybdenum cofactor guanylyltransferase activity
G7048_RS27935	COG0243	molybdopterin cofactor binding
G7048_RS27935	COG3383	formate dehydrogenase (NAD+) activity
G7048_RS27940	COG0437	4 iron, 4 sulfur cluster binding
G7048_RS27960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G7048_RS27990	COG1858	cytochrome C peroxidase
G7048_RS28005	COG3181	Tripartite tricarboxylate transporter family receptor
G7048_RS28010	COG0583	DNA-binding transcription factor activity
G7048_RS28030	COG1595	DNA-templated transcription, initiation
G7048_RS28060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7048_RS28075	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G7048_RS28085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7048_RS28135	COG2211	Major facilitator Superfamily
G7048_RS28140	COG4774	siderophore transport
G7048_RS28175	COG1116	anion transmembrane transporter activity
G7048_RS28235	COG4774	siderophore transport
G7048_RS28250	COG0642	Histidine kinase