locus-tag	class	description
DD1591_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DD1591_RS00010	COG0592	DNA-directed DNA polymerase activity
DD1591_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DD1591_RS00020	COG0187	DNA topoisomerase II activity
DD1591_RS00030	COG0742	ribosomal rna small subunit methyltransferase
DD1591_RS00035	COG0339	signal peptide processing
DD1591_RS00045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DD1591_RS00050	COG1234	tRNA 3'-trailer cleavage
DD1591_RS00055	COG4650	regulator
DD1591_RS00065	COG1690	Belongs to the RtcB family
DD1591_RS00070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DD1591_RS00075	COG1696	Membrane protein involved in D-alanine export
DD1591_RS00095	COG1522	sequence-specific DNA binding
DD1591_RS00100	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DD1591_RS00120	COG0837	glucose binding
DD1591_RS00130	COG0583	DNA-binding transcription factor activity
DD1591_RS00135	COG1063	alcohol dehydrogenase
DD1591_RS00145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DD1591_RS00150	COG4172	Belongs to the ABC transporter superfamily
DD1591_RS00160	COG0601	transmembrane transport
DD1591_RS00165	COG0747	negative chemotaxis
DD1591_RS00175	COG3977	Valine--pyruvate aminotransferase
DD1591_RS00190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DD1591_RS00195	COG0456	acetyltransferase
DD1591_RS00200	COG2818	Glycosylase
DD1591_RS00215	COG0751	glycine-tRNA ligase activity
DD1591_RS00240	COG3842	ATPase activity
DD1591_RS00260	COG2213	PTS system mannitol-specific
DD1591_RS00260	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DD1591_RS00265	COG0246	Mannitol dehydrogenase
DD1591_RS00270	COG3722	fumarate hydratase activity
DD1591_RS00275	COG0840	transmembrane signaling receptor activity
DD1591_RS00280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DD1591_RS00285	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DD1591_RS00290	COG1012	belongs to the aldehyde dehydrogenase family
DD1591_RS00295	COG1070	Carbohydrate kinase
DD1591_RS00300	COG2115	Belongs to the xylose isomerase family
DD1591_RS00305	COG4213	ABC transporter substrate-binding protein
DD1591_RS00310	COG1129	ABC transporter
DD1591_RS00315	COG4214	carbohydrate transport
DD1591_RS00320	COG2207	Transcriptional regulator
DD1591_RS00320	COG1609	Transcriptional regulator
DD1591_RS00340	COG0137	argininosuccinate synthase activity
DD1591_RS00345	COG1846	Transcriptional regulator
DD1591_RS00350	COG0697	spore germination
DD1591_RS00355	COG2313	pseudouridylate synthase activity
DD1591_RS00365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DD1591_RS00400	COG0577	efflux transmembrane transporter activity
DD1591_RS00400	COG1136	(ABC) transporter
DD1591_RS00405	COG0577	efflux transmembrane transporter activity
DD1591_RS00405	COG1136	(ABC) transporter
DD1591_RS00445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DD1591_RS00465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DD1591_RS00470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DD1591_RS00515	COG0149	triose-phosphate isomerase activity
DD1591_RS00525	COG3152	Membrane
DD1591_RS00535	COG1494	fructose-1,6-bisphosphatase
DD1591_RS00545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DD1591_RS00550	COG3074	FtsZ-dependent cytokinesis
DD1591_RS00555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DD1591_RS00560	COG1575	Belongs to the MenA family. Type 1 subfamily
DD1591_RS00565	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DD1591_RS00570	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DD1591_RS00575	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DD1591_RS00580	COG1609	Transcriptional regulator
DD1591_RS00585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DD1591_RS00595	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
DD1591_RS00600	COG0626	cystathionine gamma-synthase activity
DD1591_RS00605	COG0527	aspartate kinase activity
DD1591_RS00605	COG0460	homoserine dehydrogenase
DD1591_RS00625	COG0678	peroxiredoxin activity
DD1591_RS00625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DD1591_RS00635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DD1591_RS00650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DD1591_RS00660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DD1591_RS00700	COG0583	DNA-binding transcription factor activity
DD1591_RS00715	COG2814	Major facilitator Superfamily
DD1591_RS00725	COG3978	acetolactate synthase activity
DD1591_RS00740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DD1591_RS00760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DD1591_RS00765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DD1591_RS00770	COG0506	proline dehydrogenase activity
DD1591_RS00770	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DD1591_RS00770	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DD1591_RS00780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DD1591_RS00800	COG0248	Ppx GppA phosphatase
DD1591_RS00805	COG0513	Belongs to the DEAD box helicase family
DD1591_RS00810	COG3118	belongs to the thioredoxin family
DD1591_RS00815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DD1591_RS00820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DD1591_RS00830	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DD1591_RS00835	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DD1591_RS00845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DD1591_RS00850	COG2244	polysaccharide biosynthetic process
DD1591_RS00855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DD1591_RS00865	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DD1591_RS00900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DD1591_RS00905	COG0456	acetyltransferase
DD1591_RS00910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DD1591_RS00915	COG0765	amino acid transport
DD1591_RS00920	COG1126	abc transporter atp-binding protein
DD1591_RS00925	COG1473	amidohydrolase
DD1591_RS00930	COG3071	HemY protein
DD1591_RS00935	COG2959	enzyme of heme biosynthesis
DD1591_RS00940	COG1587	Uroporphyrinogen-III synthase
DD1591_RS00945	COG0181	hydroxymethylbilane synthase activity
DD1591_RS00965	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DD1591_RS00980	COG1011	Hydrolase
DD1591_RS00985	COG0210	DNA helicase
DD1591_RS00990	COG0598	Magnesium transport protein CorA
DD1591_RS00995	COG3180	Ammonia monooxygenase
DD1591_RS01000	COG2962	Rard protein
DD1591_RS01005	COG2050	protein possibly involved in aromatic compounds catabolism
DD1591_RS01010	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
DD1591_RS01020	COG1280	lysine exporter protein (LysE YggA)
DD1591_RS01025	COG1280	lysine exporter protein (LysE YggA)
DD1591_RS01030	COG2267	carboxylic ester hydrolase activity
DD1591_RS01035	COG0561	phosphatase activity
DD1591_RS01040	COG0584	glycerophosphoryl diester phosphodiesterase
DD1591_RS01045	COG2271	Major facilitator Superfamily
DD1591_RS01050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DD1591_RS01055	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
DD1591_RS01060	COG0247	lactate metabolic process
DD1591_RS01065	COG1741	Belongs to the pirin family
DD1591_RS01070	COG3385	transposase activity
DD1591_RS01120	COG1609	Transcriptional regulator
DD1591_RS01125	COG3265	gluconokinase activity
DD1591_RS01130	COG2610	gluconate transmembrane transporter activity
DD1591_RS01135	COG2095	MarC family integral membrane protein
DD1591_RS01140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DD1591_RS01150	COG1278	Cold shock
DD1591_RS01155	COG3275	phosphorelay sensor kinase activity
DD1591_RS01170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DD1591_RS01175	COG0297	glycogen (starch) synthase activity
DD1591_RS01180	COG0058	SHG alpha-glucan phosphorylase activity
DD1591_RS01185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DD1591_RS01190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DD1591_RS01195	COG0705	Rhomboid family
DD1591_RS01200	COG1349	DNA-binding transcription factor activity
DD1591_RS01205	COG0058	SHG alpha-glucan phosphorylase activity
DD1591_RS01210	COG1640	4-alpha-glucanotransferase
DD1591_RS01215	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DD1591_RS01215	COG0316	Belongs to the HesB IscA family
DD1591_RS01220	COG1040	competence protein
DD1591_RS01225	COG2267	carboxylic ester hydrolase activity
DD1591_RS01230	COG3328	transposase activity
DD1591_RS01240	COG2183	response to ionizing radiation
DD1591_RS01255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DD1591_RS01270	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DD1591_RS01275	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DD1591_RS01280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DD1591_RS01285	COG1011	Hydrolase
DD1591_RS01295	COG0494	nUDIX hydrolase
DD1591_RS01300	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DD1591_RS01325	COG4796	Type ii and iii secretion system protein
DD1591_RS01330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DD1591_RS01335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DD1591_RS01350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DD1591_RS01355	COG0546	phosphoglycolate phosphatase activity
DD1591_RS01365	COG4948	Mandelate Racemase Muconate Lactonizing
DD1591_RS01370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DD1591_RS01410	COG3179	chitinase
DD1591_RS01415	COG1404	Belongs to the peptidase S8 family
DD1591_RS01420	COG4753	response regulator
DD1591_RS01420	COG2207	Transcriptional regulator
DD1591_RS01450	COG3623	hexulose-6-phosphate isomerase
DD1591_RS01475	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DD1591_RS01485	COG1765	OsmC-like protein
DD1591_RS01490	COG3954	Phosphoribulokinase
DD1591_RS01500	COG0429	hydrolase of the alpha beta-hydrolase fold
DD1591_RS01510	COG0488	(ABC) transporter
DD1591_RS01515	COG2249	NAD(P)H dehydrogenase (quinone) activity
DD1591_RS01520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DD1591_RS01520	COG0475	glutathione-regulated potassium exporter activity
DD1591_RS01525	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DD1591_RS01530	COG1047	Peptidyl-prolyl cis-trans
DD1591_RS01555	COG2900	Belongs to the SlyX family
DD1591_RS01560	COG0545	Peptidyl-prolyl cis-trans isomerase
DD1591_RS01565	COG0642	Histidine kinase
DD1591_RS01570	COG0745	RESPONSE REGULATOR receiver
DD1591_RS01575	COG2194	sulfuric ester hydrolase activity
DD1591_RS01580	COG2964	Protein conserved in bacteria
DD1591_RS01585	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DD1591_RS01590	COG2923	Belongs to the DsrF TusC family
DD1591_RS01595	COG2168	tRNA wobble position uridine thiolation
DD1591_RS01600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DD1591_RS01615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DD1591_RS01630	COG0051	transcription antitermination factor activity, RNA binding
DD1591_RS01635	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DD1591_RS01640	COG0088	Forms part of the polypeptide exit tunnel
DD1591_RS01645	COG0089	rRNA binding
DD1591_RS01655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DD1591_RS01670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DD1591_RS01700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DD1591_RS01710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DD1591_RS01720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DD1591_RS01725	COG1841	ribosomal large subunit assembly
DD1591_RS01730	COG0200	Binds to the 23S rRNA
DD1591_RS01735	COG0201	protein transport
DD1591_RS01740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DD1591_RS01750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DD1591_RS01760	COG0203	ribosomal protein L17
DD1591_RS01770	COG1970	mechanosensitive ion channel activity
DD1591_RS01780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DD1591_RS01780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DD1591_RS01785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DD1591_RS01790	COG0242	peptide deformylase activity
DD1591_RS01795	COG0758	DNA mediated transformation
DD1591_RS01800	COG2922	Belongs to the Smg family
DD1591_RS01810	COG0009	L-threonylcarbamoyladenylate synthase
DD1591_RS01815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DD1591_RS01825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DD1591_RS01855	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DD1591_RS01860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DD1591_RS01870	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DD1591_RS01875	COG1414	Transcriptional regulator
DD1591_RS01880	COG0646	methionine synthase
DD1591_RS01880	COG1410	methionine synthase
DD1591_RS01885	COG0471	metal ion transport
DD1591_RS01890	COG1283	sodium-dependent phosphate transmembrane transporter activity
DD1591_RS01895	COG0527	aspartate kinase activity
DD1591_RS01900	COG0166	Belongs to the GPI family
DD1591_RS01910	COG1509	lysine 2,3-aminomutase activity
DD1591_RS01915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DD1591_RS01925	COG3040	lipid binding
DD1591_RS01930	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
DD1591_RS01935	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
DD1591_RS01940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DD1591_RS01945	COG1053	succinate dehydrogenase
DD1591_RS01950	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DD1591_RS01955	COG3264	Mechanosensitive ion channel
DD1591_RS01955	COG1511	domain protein
DD1591_RS01960	COG0688	phosphatidylethanolamine metabolic process
DD1591_RS01965	COG1162	GTPase activity
DD1591_RS01970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DD1591_RS02015	COG0840	transmembrane signaling receptor activity
DD1591_RS02020	COG0840	transmembrane signaling receptor activity
DD1591_RS02025	COG0583	DNA-binding transcription factor activity
DD1591_RS02035	COG1473	amidohydrolase
DD1591_RS02045	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DD1591_RS02050	COG1846	Transcriptional regulator
DD1591_RS02055	COG1764	response to oxidative stress
DD1591_RS02065	COG1126	abc transporter atp-binding protein
DD1591_RS02070	COG0765	amino acid transport
DD1591_RS02085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DD1591_RS02090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DD1591_RS02105	COG0582	viral genome integration into host DNA
DD1591_RS02110	COG3423	Transcriptional regulator
DD1591_RS02125	COG3423	Transcriptional regulator
DD1591_RS02145	COG3501	Rhs element vgr protein
DD1591_RS02175	COG3829	transcription factor binding
DD1591_RS02385	COG0270	DNA (cytosine-5-)-methyltransferase activity
DD1591_RS02390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DD1591_RS02415	COG0629	single-stranded DNA binding
DD1591_RS02455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DD1591_RS02465	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DD1591_RS02470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DD1591_RS02470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DD1591_RS02475	COG0802	atpase or kinase
DD1591_RS02485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DD1591_RS02490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DD1591_RS02495	COG1923	regulation of RNA biosynthetic process
DD1591_RS02500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DD1591_RS02505	COG0330	HflC and HflK could
DD1591_RS02510	COG0330	HflC and HflK could
DD1591_RS02515	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
DD1591_RS02520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DD1591_RS02525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DD1591_RS02530	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DD1591_RS02535	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DD1591_RS02540	COG1678	Uncharacterized ACR, COG1678
DD1591_RS02545	COG0189	ligase activity
DD1591_RS02550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DD1591_RS02555	COG2356	endonuclease I
DD1591_RS02560	COG3091	SprT-like family
DD1591_RS02565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DD1591_RS02570	COG1166	arginine decarboxylase activity
DD1591_RS02575	COG0738	Major facilitator superfamily
DD1591_RS02580	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DD1591_RS02585	COG3385	transposase activity
DD1591_RS02590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DD1591_RS02595	COG0126	phosphoglycerate kinase activity
DD1591_RS02605	COG0668	transmembrane transport
DD1591_RS02610	COG1414	Transcriptional regulator
DD1591_RS02615	COG2968	Membrane
DD1591_RS02620	COG0583	DNA-binding transcription factor activity
DD1591_RS02625	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DD1591_RS02630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DD1591_RS02635	COG0604	alcohol dehydrogenase
DD1591_RS02640	COG0583	DNA-binding transcription factor activity
DD1591_RS02650	COG0488	(ABC) transporter
DD1591_RS02660	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
DD1591_RS02665	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DD1591_RS02670	COG0406	alpha-ribazole phosphatase activity
DD1591_RS02675	COG2207	Transcriptional regulator
DD1591_RS02675	COG3708	Transcriptional regulator
DD1591_RS02680	COG3045	CreA protein
DD1591_RS02685	COG0745	RESPONSE REGULATOR receiver
DD1591_RS02690	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DD1591_RS02700	COG0083	homoserine kinase activity
DD1591_RS02710	COG3022	response to hydroperoxide
DD1591_RS02715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DD1591_RS02720	COG3706	GGDEF domain
DD1591_RS02725	COG0521	Mo-molybdopterin cofactor biosynthetic process
DD1591_RS02735	COG1584	GPR1 FUN34 yaaH family protein
DD1591_RS02740	COG0443	Heat shock 70 kDa protein
DD1591_RS02745	COG0484	heat shock protein binding
DD1591_RS02750	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DD1591_RS02755	COG0583	DNA-binding transcription factor activity
DD1591_RS02760	COG0268	Binds directly to 16S ribosomal RNA
DD1591_RS02765	COG0196	riboflavin kinase activity
DD1591_RS02770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DD1591_RS02775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DD1591_RS02780	COG1047	Peptidyl-prolyl cis-trans
DD1591_RS02785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DD1591_RS02800	COG0505	Belongs to the CarA family
DD1591_RS02805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DD1591_RS02810	COG1280	lysine exporter protein (LysE YggA)
DD1591_RS02815	COG2966	Psort location CytoplasmicMembrane, score
DD1591_RS02820	COG3610	response to peptide
DD1591_RS02825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DD1591_RS02835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DD1591_RS02840	COG2967	ApaG domain
DD1591_RS02845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DD1591_RS02850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DD1591_RS02855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DD1591_RS02860	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DD1591_RS02865	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DD1591_RS02870	COG0564	pseudouridine synthase activity
DD1591_RS02875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DD1591_RS02880	COG0417	DNA replication proofreading
DD1591_RS02900	COG3157	Type VI secretion system effector, Hcp
DD1591_RS02925	COG0586	Pfam SNARE associated Golgi protein
DD1591_RS02930	COG0440	acetolactate synthase activity
DD1591_RS02935	COG0028	Belongs to the TPP enzyme family
DD1591_RS02940	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DD1591_RS02945	COG1178	ABC-type Fe3 transport system permease component
DD1591_RS02955	COG4533	DNA binding
DD1591_RS02960	COG3033	Beta-eliminating lyase
DD1591_RS02975	COG0066	3-isopropylmalate dehydratase activity
DD1591_RS02985	COG0473	3-isopropylmalate dehydrogenase activity
DD1591_RS02990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DD1591_RS02995	COG1022	Amp-dependent synthetase and ligase
DD1591_RS03000	COG0028	Belongs to the TPP enzyme family
DD1591_RS03025	COG2001	Belongs to the MraZ family
DD1591_RS03030	COG0275	rRNA processing
DD1591_RS03035	COG3116	cell division
DD1591_RS03040	COG0768	penicillin binding
DD1591_RS03045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DD1591_RS03050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DD1591_RS03055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DD1591_RS03060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DD1591_RS03065	COG0772	Belongs to the SEDS family
DD1591_RS03070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DD1591_RS03075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DD1591_RS03080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DD1591_RS03085	COG0849	cell division
DD1591_RS03090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DD1591_RS03095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DD1591_RS03110	COG0653	protein targeting
DD1591_RS03115	COG0494	nUDIX hydrolase
DD1591_RS03120	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DD1591_RS03125	COG0237	dephospho-CoA kinase activity
DD1591_RS03135	COG1459	type II secretion system
DD1591_RS03140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DD1591_RS03145	COG4969	Belongs to the N-Me-Phe pilin family
DD1591_RS03165	COG3725	Membrane protein required for beta-lactamase induction
DD1591_RS03180	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DD1591_RS03185	COG0508	dehydrogenase complex catalyzes the overall conversion of
DD1591_RS03190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DD1591_RS03200	COG2079	MmgE PrpD family protein
DD1591_RS03210	COG3112	Uncharacterised protein family (UPF0231)
DD1591_RS03215	COG0840	transmembrane signaling receptor activity
DD1591_RS03225	COG2731	YhcH YjgK YiaL family protein
DD1591_RS03240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DD1591_RS03245	COG1454	alcohol dehydrogenase
DD1591_RS03250	COG3395	kinase activity
DD1591_RS03255	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DD1591_RS03260	COG1349	DNA-binding transcription factor activity
DD1591_RS03270	COG2368	4-hydroxyphenylacetate
DD1591_RS03275	COG0803	Belongs to the bacterial solute-binding protein 9 family
DD1591_RS03280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DD1591_RS03285	COG1121	(ABC) transporter
DD1591_RS03290	COG2971	BadF BadG BcrA BcrD
DD1591_RS03310	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DD1591_RS03315	COG3842	ATPase activity
DD1591_RS03320	COG1175	transmembrane transport
DD1591_RS03325	COG0395	ABC-type sugar transport system, permease component
DD1591_RS03330	COG1609	Transcriptional regulator
DD1591_RS03335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DD1591_RS03435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DD1591_RS03455	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DD1591_RS03460	COG0432	Pfam Uncharacterised protein family UPF0047
DD1591_RS03475	COG1518	maintenance of DNA repeat elements
DD1591_RS03480	COG1203	CRISPR-associated helicase, Cas3
DD1591_RS03505	COG1448	Aminotransferase
DD1591_RS03515	COG1522	sequence-specific DNA binding
DD1591_RS03535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DD1591_RS03550	COG2124	cytochrome p450
DD1591_RS03560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DD1591_RS03595	COG0583	DNA-binding transcription factor activity
DD1591_RS03610	COG2188	Transcriptional regulator
DD1591_RS03625	COG4149	molybdate abc transporter
DD1591_RS03635	COG3842	ATPase activity
DD1591_RS03645	COG0583	DNA-binding transcription factor activity
DD1591_RS03655	COG1609	Transcriptional regulator
DD1591_RS03660	COG1447	Phosphotransferase system cellobiose-specific component IIA
DD1591_RS03665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DD1591_RS03670	COG2723	6-phospho-beta-galactosidase activity
DD1591_RS03680	COG2186	Transcriptional regulator
DD1591_RS03705	COG1609	Transcriptional regulator
DD1591_RS03710	COG3711	transcriptional antiterminator
DD1591_RS03715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DD1591_RS03715	COG1263	PTS System
DD1591_RS03715	COG2190	(PTS) system
DD1591_RS03720	COG2723	6-phospho-beta-galactosidase activity
DD1591_RS03725	COG2723	6-phospho-beta-galactosidase activity
DD1591_RS03730	COG0204	Acyl-transferase
DD1591_RS03730	COG0318	PFAM AMP-dependent synthetase and ligase
DD1591_RS03735	COG0477	Major facilitator Superfamily
DD1591_RS03740	COG2153	protein acetylation
DD1591_RS03750	COG3706	GGDEF domain
DD1591_RS03755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DD1591_RS03760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DD1591_RS03765	COG1872	DUF167
DD1591_RS03770	COG0762	integral membrane protein
DD1591_RS03775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DD1591_RS03780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DD1591_RS03785	COG2805	Type II/IV secretion system protein
DD1591_RS03790	COG5001	Diguanylate cyclase
DD1591_RS03795	COG0402	S-adenosylhomocysteine deaminase activity
DD1591_RS03805	COG0840	transmembrane signaling receptor activity
DD1591_RS03810	COG1959	2 iron, 2 sulfur cluster binding
DD1591_RS03815	COG0557	exoribonuclease II activity
DD1591_RS03820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DD1591_RS03825	COG0840	transmembrane signaling receptor activity
DD1591_RS03840	COG0840	transmembrane signaling receptor activity
DD1591_RS03845	COG1073	alpha beta
DD1591_RS03855	COG2965	DNA replication, synthesis of RNA primer
DD1591_RS03860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DD1591_RS03865	COG0359	binds to the 23S rRNA
DD1591_RS03875	COG3061	Opacity-associated protein A
DD1591_RS03880	COG0545	Peptidyl-prolyl cis-trans isomerase
DD1591_RS03890	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DD1591_RS03895	COG0737	Belongs to the 5'-nucleotidase family
DD1591_RS03910	COG1253	flavin adenine dinucleotide binding
DD1591_RS03915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DD1591_RS03920	COG0729	surface antigen
DD1591_RS03925	COG2911	Protein conserved in bacteria
DD1591_RS03930	COG2105	PFAM AIG2 family protein
DD1591_RS03935	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DD1591_RS03945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DD1591_RS03950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DD1591_RS03955	COG1968	undecaprenyl-diphosphatase activity
DD1591_RS03960	COG0617	tRNA 3'-terminal CCA addition
DD1591_RS03965	COG4991	sh3 domain protein
DD1591_RS03970	COG3025	triphosphatase activity
DD1591_RS03975	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DD1591_RS03980	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DD1591_RS03980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DD1591_RS03985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DD1591_RS03990	COG3530	Putative quorum-sensing-regulated virulence factor
DD1591_RS04005	COG0840	transmembrane signaling receptor activity
DD1591_RS04010	COG2721	sulfolactate sulfo-lyase activity
DD1591_RS04015	COG2271	Major facilitator Superfamily
DD1591_RS04020	COG4948	Mandelate Racemase Muconate Lactonizing
DD1591_RS04025	COG4948	Mandelate Racemase Muconate Lactonizing
DD1591_RS04035	COG2084	Dehydrogenase
DD1591_RS04040	COG1929	Belongs to the glycerate kinase type-1 family
DD1591_RS04050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DD1591_RS04055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DD1591_RS04060	COG3956	TIGRFAM MazG family protein
DD1591_RS04065	COG0504	CTP synthase activity
DD1591_RS04080	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DD1591_RS04090	COG0602	queuosine metabolic process
DD1591_RS04095	COG0720	synthase
DD1591_RS04115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DD1591_RS04120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DD1591_RS04125	COG0175	sulfate reduction
DD1591_RS04130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DD1591_RS04130	COG1648	precorrin-2 dehydrogenase activity
DD1591_RS04140	COG2895	sulfate adenylyltransferase (ATP) activity
DD1591_RS04145	COG0529	Catalyzes the synthesis of activated sulfate
DD1591_RS04155	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DD1591_RS04160	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DD1591_RS04165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DD1591_RS04170	COG0585	pseudouridine synthase activity
DD1591_RS04175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DD1591_RS04190	COG0442	prolyl-tRNA aminoacylation
DD1591_RS04195	COG1720	tRNA m6t6A37 methyltransferase activity
DD1591_RS04205	COG1464	Belongs to the NlpA lipoprotein family
DD1591_RS04210	COG2011	ABC-type metal ion transport system permease component
DD1591_RS04220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DD1591_RS04255	COG0477	Major facilitator Superfamily
DD1591_RS04260	COG5544	Lipoprotein
DD1591_RS04265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DD1591_RS04270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DD1591_RS04270	COG0045	succinate-CoA ligase (ADP-forming) activity
DD1591_RS04270	COG1042	CoA-binding domain protein
DD1591_RS04275	COG3148	PFAM DTW domain containing protein
DD1591_RS04280	COG3118	belongs to the thioredoxin family
DD1591_RS04290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DD1591_RS04295	COG2814	Major facilitator Superfamily
DD1591_RS04300	COG1566	PFAM secretion protein HlyD family protein
DD1591_RS04305	COG1846	Transcriptional regulator
DD1591_RS04315	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DD1591_RS04320	COG2814	Major facilitator Superfamily
DD1591_RS04325	COG2113	Glycine betaine
DD1591_RS04330	COG4176	ABC-type proline glycine betaine transport system permease component
DD1591_RS04335	COG4175	Glycine betaine
DD1591_RS04345	COG1953	Uracil, thiamine, allantoin
DD1591_RS04410	COG0765	amino acid transport
DD1591_RS04420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DD1591_RS04435	COG0436	Aminotransferase
DD1591_RS04440	COG0235	Class ii aldolase
DD1591_RS04445	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DD1591_RS04450	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DD1591_RS04455	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DD1591_RS04460	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DD1591_RS04465	COG1960	acyl-CoA dehydrogenase activity
DD1591_RS04470	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DD1591_RS04475	COG0121	glutamine amidotransferase
DD1591_RS04480	COG3034	peptidoglycan biosynthetic process
DD1591_RS04485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DD1591_RS04490	COG2195	Cleaves the N-terminal amino acid of tripeptides
DD1591_RS04500	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DD1591_RS04505	COG1073	alpha beta
DD1591_RS04515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DD1591_RS04520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DD1591_RS04540	COG3423	Transcriptional regulator
DD1591_RS04545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DD1591_RS04550	COG1518	maintenance of DNA repeat elements
DD1591_RS04560	COG1857	crispr-associated protein
DD1591_RS04610	COG0582	viral genome integration into host DNA
DD1591_RS04625	COG4983	Phage plasmid primase, P4 family domain protein
DD1591_RS04660	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DD1591_RS04665	COG3596	GTP binding
DD1591_RS04675	COG2003	Belongs to the UPF0758 family
DD1591_RS04755	COG1696	Membrane protein involved in D-alanine export
DD1591_RS04760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DD1591_RS04780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DD1591_RS04790	COG3275	phosphorelay sensor kinase activity
DD1591_RS04800	COG1966	Carbon starvation protein
DD1591_RS04805	COG2879	small protein
DD1591_RS04810	COG0523	cobalamin synthesis protein
DD1591_RS04820	COG1012	belongs to the aldehyde dehydrogenase family
DD1591_RS04830	COG0688	phosphatidylethanolamine metabolic process
DD1591_RS04835	COG1172	Belongs to the binding-protein-dependent transport system permease family
DD1591_RS04840	COG1172	Belongs to the binding-protein-dependent transport system permease family
DD1591_RS04845	COG1129	ABC transporter
DD1591_RS04850	COG1879	ABC-type sugar transport system periplasmic component
DD1591_RS04875	COG1280	lysine exporter protein (LysE YggA)
DD1591_RS04880	COG3038	cytochrome b561
DD1591_RS04895	COG1546	Belongs to the CinA family
DD1591_RS04900	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DD1591_RS04905	COG2137	regulation of response to DNA damage stimulus
DD1591_RS04910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DD1591_RS04915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DD1591_RS04940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DD1591_RS04945	COG1238	metal cluster binding
DD1591_RS04950	COG2918	glutathione biosynthetic process
DD1591_RS04955	COG1854	S-ribosylhomocysteine lyase activity
DD1591_RS04960	COG4137	Cytochrome C assembly protein
DD1591_RS04965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DD1591_RS04970	COG0228	four-way junction DNA binding
DD1591_RS04975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DD1591_RS04980	COG0336	Belongs to the RNA methyltransferase TrmD family
DD1591_RS05000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DD1591_RS05005	COG1605	Chorismate mutase
DD1591_RS05005	COG0287	Prephenate dehydrogenase
DD1591_RS05010	COG1605	Chorismate mutase
DD1591_RS05010	COG0077	Prephenate dehydratase
DD1591_RS05015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DD1591_RS05020	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DD1591_RS05025	COG0564	pseudouridine synthase activity
DD1591_RS05030	COG1496	oxidoreductase activity
DD1591_RS05035	COG0542	response to heat
DD1591_RS05065	COG3021	interspecies interaction between organisms
DD1591_RS05070	COG0741	lytic transglycosylase activity
DD1591_RS05070	COG1388	LysM domain
DD1591_RS05075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DD1591_RS05080	COG2226	methyltransferase
DD1591_RS05090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DD1591_RS05105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DD1591_RS05110	COG1780	Probably involved in ribonucleotide reductase function
DD1591_RS05120	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DD1591_RS05125	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DD1591_RS05140	COG3842	ATPase activity
DD1591_RS05155	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DD1591_RS05160	COG0288	reversible hydration of carbon dioxide
DD1591_RS05165	COG1131	(ABC) transporter
DD1591_RS05170	COG0842	Transport permease protein
DD1591_RS05175	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DD1591_RS05180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DD1591_RS05185	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DD1591_RS05190	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DD1591_RS05195	COG0617	tRNA 3'-terminal CCA addition
DD1591_RS05200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DD1591_RS05205	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DD1591_RS05210	COG1489	DNA binding
DD1591_RS05215	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DD1591_RS05220	COG1643	Atp-dependent helicase
DD1591_RS05225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DD1591_RS05235	COG0316	Belongs to the HesB IscA family
DD1591_RS05240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DD1591_RS05245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DD1591_RS05250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DD1591_RS05255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DD1591_RS05260	COG3835	regulator
DD1591_RS05265	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DD1591_RS05270	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DD1591_RS05275	COG4208	sulfate ABC transporter
DD1591_RS05280	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DD1591_RS05285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DD1591_RS05315	COG1447	Phosphotransferase system cellobiose-specific component IIA
DD1591_RS05340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DD1591_RS05345	COG2873	o-acetylhomoserine
DD1591_RS05360	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DD1591_RS05365	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
DD1591_RS05370	COG0513	Belongs to the DEAD box helicase family
DD1591_RS05375	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DD1591_RS05380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DD1591_RS05390	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
DD1591_RS05400	COG3086	response to oxidative stress
DD1591_RS05405	COG0481	GTPase activity
DD1591_RS05415	COG0571	ribonuclease III activity
DD1591_RS05420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DD1591_RS05425	COG1381	Involved in DNA repair and RecF pathway recombination
DD1591_RS05430	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DD1591_RS05435	COG0736	holo-[acyl-carrier-protein] synthase activity
DD1591_RS05440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DD1591_RS05445	COG2200	EAL domain
DD1591_RS05470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DD1591_RS05480	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DD1591_RS05485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DD1591_RS05485	COG0047	phosphoribosylformylglycinamidine synthase activity
DD1591_RS05490	COG2205	protein histidine kinase activity
DD1591_RS05500	COG2204	response regulator
DD1591_RS05505	COG0347	Belongs to the P(II) protein family
DD1591_RS05510	COG4677	pectinesterase activity
DD1591_RS05535	COG1017	nitric oxide dioxygenase activity
DD1591_RS05535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DD1591_RS05540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DD1591_RS05545	COG2814	Major facilitator Superfamily
DD1591_RS05550	COG3683	transport system, periplasmic component
DD1591_RS05555	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
DD1591_RS05565	COG1120	ATPase activity
DD1591_RS05570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DD1591_RS05580	COG0483	inositol monophosphate 1-phosphatase activity
DD1591_RS05585	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DD1591_RS05590	COG1959	2 iron, 2 sulfur cluster binding
DD1591_RS05600	COG0822	iron-sulfur transferase activity
DD1591_RS05605	COG0316	Belongs to the HesB IscA family
DD1591_RS05610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DD1591_RS05615	COG0443	Heat shock 70 kDa protein
DD1591_RS05620	COG0633	Ferredoxin
DD1591_RS05625	COG2975	iron-sulfur cluster assembly
DD1591_RS05630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DD1591_RS05640	COG2897	thiosulfate sulfurtransferase activity
DD1591_RS05645	COG0105	UTP biosynthetic process
DD1591_RS05650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DD1591_RS05660	COG1426	Protein conserved in bacteria
DD1591_RS05665	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DD1591_RS05670	COG0124	histidyl-tRNA synthetase
DD1591_RS05675	COG2976	Protein conserved in bacteria
DD1591_RS05680	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DD1591_RS05685	COG1160	GTP binding
DD1591_RS05690	COG1645	bacterial-type flagellum-dependent swarming motility
DD1591_RS05705	COG1570	exodeoxyribonuclease VII activity
DD1591_RS05710	COG0516	GMP reductase activity
DD1591_RS05710	COG0517	IMP dehydrogenase activity
DD1591_RS05715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DD1591_RS05715	COG0519	Catalyzes the synthesis of GMP from XMP
DD1591_RS05720	COG0582	viral genome integration into host DNA
DD1591_RS05740	COG2003	Belongs to the UPF0758 family
DD1591_RS05745	COG5489	Protein of unknown function (DUF736)
DD1591_RS05790	COG3846	protein secretion by the type IV secretion system
DD1591_RS05820	COG2916	Histone family protein nucleoid-structuring protein H-NS
DD1591_RS05840	COG3423	Transcriptional regulator
DD1591_RS05850	COG4104	PAAR repeat-containing protein
DD1591_RS05850	COG3209	COG3209 Rhs family protein
DD1591_RS05860	COG3501	Rhs element vgr protein
DD1591_RS05870	COG1309	transcriptional regulator
DD1591_RS05890	COG1733	regulation of RNA biosynthetic process
DD1591_RS05905	COG3272	Protein of unknown function (DUF1722)
DD1591_RS05910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DD1591_RS05925	COG0300	oxidoreductase activity
DD1591_RS05935	COG0789	Transcriptional regulator
DD1591_RS05965	COG0765	amino acid transport
DD1591_RS05975	COG0765	amino acid transport
DD1591_RS05980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DD1591_RS05985	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DD1591_RS05990	COG0351	phosphomethylpyrimidine kinase
DD1591_RS06005	COG0673	inositol 2-dehydrogenase activity
DD1591_RS06015	COG2211	Major facilitator Superfamily
DD1591_RS06020	COG3622	Belongs to the hyi family
DD1591_RS06025	COG3223	Belongs to the PsiE family
DD1591_RS06030	COG0826	peptidase U32
DD1591_RS06035	COG0435	Glutathione S-transferase
DD1591_RS06040	COG0745	RESPONSE REGULATOR receiver
DD1591_RS06045	COG2205	protein histidine kinase activity
DD1591_RS06050	COG0477	Major facilitator Superfamily
DD1591_RS06055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DD1591_RS06060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DD1591_RS06065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DD1591_RS06070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DD1591_RS06075	COG0667	Aldo Keto reductase
DD1591_RS06080	COG2885	chlorophyll binding
DD1591_RS06080	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DD1591_RS06085	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
DD1591_RS06090	COG3070	regulator of competence-specific genes
DD1591_RS06095	COG1289	transmembrane transporter activity
DD1591_RS06100	COG3304	Inner membrane component domain
DD1591_RS06105	COG0210	DNA helicase
DD1591_RS06110	COG1803	Methylglyoxal synthase
DD1591_RS06115	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DD1591_RS06120	COG1832	CoA-binding protein
DD1591_RS06125	COG3785	DNA binding
DD1591_RS06130	COG1254	Belongs to the acylphosphatase family
DD1591_RS06135	COG2920	part of a sulfur-relay system
DD1591_RS06140	COG0670	Belongs to the BI1 family
DD1591_RS06195	COG0589	response to stress
DD1591_RS06200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DD1591_RS06215	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DD1591_RS06220	COG0573	inorganic phosphate transmembrane transporter activity
DD1591_RS06225	COG0581	inorganic phosphate transmembrane transporter activity
DD1591_RS06230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DD1591_RS06240	COG1760	l-serine dehydratase
DD1591_RS06245	COG0814	amino acid
DD1591_RS06250	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DD1591_RS06255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DD1591_RS06260	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DD1591_RS06265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DD1591_RS06275	COG0215	cysteine-tRNA ligase activity
DD1591_RS06280	COG2501	S4 domain
DD1591_RS06285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DD1591_RS06290	COG0840	transmembrane signaling receptor activity
DD1591_RS06305	COG0402	S-adenosylhomocysteine deaminase activity
DD1591_RS06330	COG4598	ABC transporter
DD1591_RS06350	COG2986	histidine ammonia-lyase
DD1591_RS06355	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DD1591_RS06360	COG1802	Transcriptional regulator
DD1591_RS06365	COG0246	Mannitol dehydrogenase
DD1591_RS06370	COG0477	Major facilitator Superfamily
DD1591_RS06375	COG1063	alcohol dehydrogenase
DD1591_RS06380	COG4948	Mandelate Racemase Muconate Lactonizing
DD1591_RS06395	COG5297	Belongs to the glycosyl hydrolase family 6
DD1591_RS06410	COG2182	Extracellular solute-binding protein
DD1591_RS06415	COG1175	transmembrane transport
DD1591_RS06420	COG3833	ABC-type maltose transport systems, permease component
DD1591_RS06430	COG1874	Beta-galactosidase
DD1591_RS06435	COG1263	PTS System
DD1591_RS06435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DD1591_RS06455	COG2850	peptidyl-arginine hydroxylation
DD1591_RS06480	COG3706	GGDEF domain
DD1591_RS06500	COG3264	Mechanosensitive ion channel
DD1591_RS06500	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DD1591_RS06505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DD1591_RS06510	COG0436	Aminotransferase
DD1591_RS06520	COG3266	domain, Protein
DD1591_RS06595	COG1902	pentaerythritol trinitrate reductase activity
DD1591_RS06600	COG2050	protein possibly involved in aromatic compounds catabolism
DD1591_RS06605	COG1028	Short-chain dehydrogenase reductase Sdr
DD1591_RS06610	COG3433	isochorismatase activity
DD1591_RS06610	COG1535	isochorismatase
DD1591_RS06615	COG1021	2,3-dihydroxybenzoate-AMP ligase
DD1591_RS06620	COG1169	isochorismate synthase
DD1591_RS06625	COG4774	siderophore transport
DD1591_RS06630	COG2382	esterase
DD1591_RS06650	COG1120	ATPase activity
DD1591_RS06655	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DD1591_RS06660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DD1591_RS06670	COG4592	Periplasmic binding protein
DD1591_RS06685	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DD1591_RS06710	COG0579	oxidoreductase
DD1591_RS06715	COG2067	long-chain fatty acid transport protein
DD1591_RS06720	COG3691	Protein conserved in bacteria
DD1591_RS06725	COG0183	Belongs to the thiolase family
DD1591_RS06730	COG1250	3-hydroxyacyl-CoA dehydrogenase
DD1591_RS06730	COG1024	Enoyl-CoA hydratase
DD1591_RS06735	COG2062	phosphohistidine phosphatase, SixA
DD1591_RS06740	COG2840	Smr protein MutS2
DD1591_RS06745	COG2890	protein-(glutamine-N5) methyltransferase activity
DD1591_RS06750	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DD1591_RS06755	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
DD1591_RS06760	COG0730	response to heat
DD1591_RS06765	COG3101	peptidyl-lysine hydroxylation
DD1591_RS06795	COG1764	response to oxidative stress
DD1591_RS06815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DD1591_RS06815	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DD1591_RS06820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DD1591_RS06850	COG0642	Histidine kinase
DD1591_RS06855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DD1591_RS06860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DD1591_RS06865	COG0101	tRNA pseudouridine synthase activity
DD1591_RS06870	COG0586	Pfam SNARE associated Golgi protein
DD1591_RS06875	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DD1591_RS06880	COG0285	dihydrofolate synthase activity
DD1591_RS06885	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
DD1591_RS06890	COG1286	toxin biosynthetic process
DD1591_RS06895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DD1591_RS06900	COG0163	prenyltransferase activity
DD1591_RS06910	COG4215	(ABC) transporter
DD1591_RS06920	COG4598	ABC transporter
DD1591_RS06925	COG1090	epimerase
DD1591_RS06930	COG0625	glutathione transferase activity
DD1591_RS06935	COG0622	Phosphoesterase
DD1591_RS06940	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DD1591_RS06945	COG0857	belongs to the CobB CobQ family
DD1591_RS06945	COG0280	phosphate acetyltransferase
DD1591_RS06950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DD1591_RS06955	COG3092	negative regulation of chromosome organization
DD1591_RS06960	COG3013	Belongs to the UPF0304 family
DD1591_RS06965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DD1591_RS06970	COG0490	domain, Protein
DD1591_RS06970	COG0471	metal ion transport
DD1591_RS06975	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DD1591_RS06980	COG0436	Aminotransferase
DD1591_RS06985	COG0583	DNA-binding transcription factor activity
DD1591_RS06990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DD1591_RS07000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DD1591_RS07000	COG0649	NAD binding
DD1591_RS07010	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DD1591_RS07020	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DD1591_RS07025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DD1591_RS07030	COG0839	Belongs to the complex I subunit 6 family
DD1591_RS07035	COG0713	ATP synthesis coupled electron transport
DD1591_RS07040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DD1591_RS07045	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DD1591_RS07050	COG1007	ATP synthesis coupled electron transport
DD1591_RS07060	COG0384	phenazine biosynthesis protein PhzF
DD1591_RS07065	COG0488	(ABC) transporter
DD1591_RS07070	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DD1591_RS07075	COG0437	4 iron, 4 sulfur cluster binding
DD1591_RS07080	COG5557	Pfam Polysulphide reductase, NrfD
DD1591_RS07085	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DD1591_RS07090	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DD1591_RS07095	COG1773	rubredoxin
DD1591_RS07105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DD1591_RS07110	COG0298	carbon dioxide binding
DD1591_RS07115	COG0409	Hydrogenase expression formation protein
DD1591_RS07120	COG0309	Hydrogenase expression formation protein (HypE)
DD1591_RS07130	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DD1591_RS07140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DD1591_RS07140	COG0519	Catalyzes the synthesis of GMP from XMP
DD1591_RS07145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DD1591_RS07150	COG3383	formate dehydrogenase (NAD+) activity
DD1591_RS07150	COG0243	molybdopterin cofactor binding
DD1591_RS07155	COG0437	4 iron, 4 sulfur cluster binding
DD1591_RS07160	COG2864	formate dehydrogenase
DD1591_RS07170	COG2271	Major facilitator Superfamily
DD1591_RS07175	COG3058	Necessary for formate dehydrogenase activity
DD1591_RS07180	COG0657	acetylesterase activity
DD1591_RS07190	COG3507	Belongs to the glycosyl hydrolase 43 family
DD1591_RS07195	COG3707	response regulator
DD1591_RS07200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DD1591_RS07210	COG1116	anion transmembrane transporter activity
DD1591_RS07215	COG2146	nitrite reductase [NAD(P)H] activity
DD1591_RS07215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DD1591_RS07220	COG0243	molybdopterin cofactor binding
DD1591_RS07225	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DD1591_RS07225	COG1648	precorrin-2 dehydrogenase activity
DD1591_RS07260	COG0436	Aminotransferase
DD1591_RS07265	COG0583	DNA-binding transcription factor activity
DD1591_RS07270	COG1619	proteins homologs of microcin C7 resistance protein MccF
DD1591_RS07275	COG0840	transmembrane signaling receptor activity
DD1591_RS07290	COG1819	glycosyl
DD1591_RS07300	COG1309	transcriptional regulator
DD1591_RS07305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DD1591_RS07325	COG0667	Aldo Keto reductase
DD1591_RS07370	COG4227	nucleotidyltransferase activity
DD1591_RS07400	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
DD1591_RS07410	COG3504	Conjugal transfer protein
DD1591_RS07460	COG3328	transposase activity
DD1591_RS07465	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DD1591_RS07490	COG3423	Transcriptional regulator
DD1591_RS07495	COG1476	TRANSCRIPTIONal
DD1591_RS07505	COG3501	Rhs element vgr protein
DD1591_RS07540	COG5489	Protein of unknown function (DUF736)
DD1591_RS07555	COG3423	Transcriptional regulator
DD1591_RS07570	COG0582	viral genome integration into host DNA
DD1591_RS07585	COG1113	amino acid transport
DD1591_RS07600	COG2197	response regulator
DD1591_RS07605	COG0322	excinuclease ABC activity
DD1591_RS07610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DD1591_RS07675	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DD1591_RS07685	COG0534	Mate efflux family protein
DD1591_RS07695	COG0840	transmembrane signaling receptor activity
DD1591_RS07720	COG0643	Histidine kinase
DD1591_RS07720	COG2198	Histidine kinase
DD1591_RS07725	COG0835	chemotaxis
DD1591_RS07730	COG0840	transmembrane signaling receptor activity
DD1591_RS07735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DD1591_RS07740	COG2201	protein-glutamate methylesterase activity
DD1591_RS07745	COG0745	RESPONSE REGULATOR receiver
DD1591_RS07755	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DD1591_RS07760	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DD1591_RS07775	COG2747	anti-sigma28 factor FlgM
DD1591_RS07785	COG1815	bacterial-type flagellum-dependent cell motility
DD1591_RS07790	COG1558	bacterial-type flagellum-dependent cell motility
DD1591_RS07795	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DD1591_RS07800	COG1749	Flagellar hook protein flgE
DD1591_RS07805	COG4787	bacterial-type flagellum-dependent cell motility
DD1591_RS07815	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DD1591_RS07820	COG1706	bacterial-type flagellum-dependent cell motility
DD1591_RS07835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DD1591_RS07870	COG1580	Controls the rotational direction of flagella during chemotaxis
DD1591_RS07885	COG1157	protein secretion by the type III secretion system
DD1591_RS07890	COG1317	bacterial-type flagellum organization
DD1591_RS07905	COG1677	Flagellar hook-basal body complex protein FliE
DD1591_RS07920	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DD1591_RS07930	COG0500	methyltransferase
DD1591_RS07940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DD1591_RS07945	COG0673	inositol 2-dehydrogenase activity
DD1591_RS07970	COG1191	sigma factor activity
DD1591_RS07980	COG1702	phosphate starvation-inducible protein PhoH
DD1591_RS07990	COG3385	transposase activity
DD1591_RS08005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DD1591_RS08010	COG1067	ATP-dependent peptidase activity
DD1591_RS08030	COG0840	transmembrane signaling receptor activity
DD1591_RS08040	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DD1591_RS08045	COG2943	transferase activity, transferring hexosyl groups
DD1591_RS08050	COG1560	Kdo2-lipid A biosynthetic process
DD1591_RS08055	COG1054	Belongs to the UPF0176 family
DD1591_RS08065	COG3038	cytochrome b561
DD1591_RS08080	COG0418	dihydroorotase activity
DD1591_RS08090	COG1530	ribonuclease E activity
DD1591_RS08105	COG0424	maF-like protein
DD1591_RS08110	COG1399	metal-binding, possibly nucleic acid-binding protein
DD1591_RS08115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DD1591_RS08120	COG0416	fatty acid biosynthetic process
DD1591_RS08125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DD1591_RS08135	COG1028	Short-chain dehydrogenase reductase Sdr
DD1591_RS08140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DD1591_RS08145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DD1591_RS08150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DD1591_RS08155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DD1591_RS08165	COG0470	DNA polymerase III
DD1591_RS08170	COG0084	hydrolase, TatD family'
DD1591_RS08175	COG1263	PTS System
DD1591_RS08175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DD1591_RS08180	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DD1591_RS08185	COG0537	adenosine 5'-monophosphoramidase activity
DD1591_RS08190	COG5633	Lipoprotein
DD1591_RS08195	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
DD1591_RS08205	COG1472	Belongs to the glycosyl hydrolase 3 family
DD1591_RS08215	COG1252	NADH dehydrogenase
DD1591_RS08220	COG3134	Outer membrane lipoprotein
DD1591_RS08225	COG1609	Transcriptional regulator
DD1591_RS08230	COG2271	Major facilitator Superfamily
DD1591_RS08245	COG0443	Heat shock 70 kDa protein
DD1591_RS08250	COG2200	EAL domain
DD1591_RS08255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DD1591_RS08260	COG4591	ABC-type transport system involved in lipoprotein release permease component
DD1591_RS08265	COG1136	(ABC) transporter
DD1591_RS08270	COG4591	ABC-type transport system involved in lipoprotein release permease component
DD1591_RS08290	COG4139	cobalamin transport
DD1591_RS08295	COG0386	Belongs to the glutathione peroxidase family
DD1591_RS08300	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
DD1591_RS08305	COG0791	NLP P60 protein
DD1591_RS08315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DD1591_RS08320	COG2989	Protein conserved in bacteria
DD1591_RS08325	COG3108	Peptidase M15
DD1591_RS08330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DD1591_RS08335	COG1032	radical SAM domain protein
DD1591_RS08340	COG1448	Aminotransferase
DD1591_RS08355	COG0017	Asparaginyl-tRNA synthetase
DD1591_RS08360	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DD1591_RS08365	COG0308	aminopeptidase N
DD1591_RS08375	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DD1591_RS08380	COG1116	anion transmembrane transporter activity
DD1591_RS08385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DD1591_RS08390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DD1591_RS08395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DD1591_RS08400	COG0431	NADPH-dependent FMN reductase
DD1591_RS08405	COG0167	dihydroorotate dehydrogenase activity
DD1591_RS08415	COG0633	Ferredoxin
DD1591_RS08415	COG3217	Mosc domain protein beta barrel domain protein
DD1591_RS08420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DD1591_RS08420	COG0116	Belongs to the methyltransferase superfamily
DD1591_RS08425	COG0488	(ABC) transporter
DD1591_RS08430	COG2995	paraquat-inducible protein a
DD1591_RS08435	COG3008	intermembrane lipid transfer
DD1591_RS08435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DD1591_RS08440	COG3009	Protein conserved in bacteria
DD1591_RS08445	COG3130	regulation of translation
DD1591_RS08450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DD1591_RS08455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DD1591_RS08460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DD1591_RS08460	COG0574	Belongs to the PEP-utilizing enzyme family
DD1591_RS08465	COG0628	permease
DD1591_RS08470	COG0247	lactate metabolic process
DD1591_RS08470	COG0277	FAD linked oxidase domain protein
DD1591_RS08475	COG2050	protein possibly involved in aromatic compounds catabolism
DD1591_RS08485	COG0316	Belongs to the HesB IscA family
DD1591_RS08490	COG0719	Fe-S assembly protein
DD1591_RS08495	COG0396	ATPase activity
DD1591_RS08500	COG0719	Fe-S assembly protein
DD1591_RS08505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DD1591_RS08510	COG2166	iron-sulfur cluster assembly
DD1591_RS08515	COG1376	ErfK ybiS ycfS ynhG family protein
DD1591_RS08515	COG1388	LysM domain
DD1591_RS08520	COG4238	major outer membrane lipoprotein
DD1591_RS08550	COG2382	esterase
DD1591_RS08570	COG2207	Transcriptional regulator
DD1591_RS08590	COG0534	Mate efflux family protein
DD1591_RS08595	COG0307	riboflavin synthase, alpha
DD1591_RS08600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DD1591_RS08605	COG1609	Transcriptional regulator
DD1591_RS08610	COG0791	NLP P60 protein
DD1591_RS08615	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DD1591_RS08620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DD1591_RS08625	COG0346	lactoylglutathione lyase activity
DD1591_RS08640	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DD1591_RS08645	COG3895	Periplasmic Protein
DD1591_RS08650	COG0259	pyridoxamine-phosphate oxidase activity
DD1591_RS08660	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DD1591_RS08665	COG0625	glutathione transferase activity
DD1591_RS08690	COG0671	phosphoesterase, PA-phosphatase related
DD1591_RS08695	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
DD1591_RS08700	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DD1591_RS08710	COG0023	Translation Initiation Factor
DD1591_RS08720	COG0235	Class ii aldolase
DD1591_RS08730	COG1966	Carbon starvation protein
DD1591_RS08735	COG4989	oxidoreductase activity
DD1591_RS08740	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
DD1591_RS08755	COG0243	molybdopterin cofactor binding
DD1591_RS08770	COG4172	Belongs to the ABC transporter superfamily
DD1591_RS08775	COG4171	peptide transport system, permease
DD1591_RS08790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DD1591_RS08795	COG1842	Phage shock protein A
DD1591_RS08805	COG1983	PspC domain protein
DD1591_RS08810	COG3106	COG3106 Predicted ATPase
DD1591_RS08815	COG3768	UPF0283 membrane protein
DD1591_RS08820	COG2271	Major facilitator Superfamily
DD1591_RS08840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DD1591_RS08855	COG0477	Major facilitator Superfamily
DD1591_RS08860	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DD1591_RS08865	COG2866	Carboxypeptidase
DD1591_RS08870	COG4166	transmembrane transport
DD1591_RS08875	COG0598	Magnesium transport protein CorA
DD1591_RS08880	COG0037	tRNA processing
DD1591_RS08900	COG0840	transmembrane signaling receptor activity
DD1591_RS08910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DD1591_RS08915	COG0840	transmembrane signaling receptor activity
DD1591_RS08920	COG2911	Protein conserved in bacteria
DD1591_RS08930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DD1591_RS08935	COG1643	Atp-dependent helicase
DD1591_RS08940	COG1620	l-lactate permease
DD1591_RS08945	COG3591	Belongs to the peptidase S1B family
DD1591_RS08955	COG2205	protein histidine kinase activity
DD1591_RS08960	COG0745	RESPONSE REGULATOR receiver
DD1591_RS08970	COG0659	secondary active sulfate transmembrane transporter activity
DD1591_RS08975	COG0387	Pfam Sodium calcium exchanger
DD1591_RS08980	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DD1591_RS08985	COG0601	transmembrane transport
DD1591_RS08990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DD1591_RS08995	COG0444	Belongs to the ABC transporter superfamily
DD1591_RS09005	COG0747	negative chemotaxis
DD1591_RS09015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DD1591_RS09025	COG0840	transmembrane signaling receptor activity
DD1591_RS09040	COG0402	S-adenosylhomocysteine deaminase activity
DD1591_RS09090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DD1591_RS09100	COG2840	Smr protein MutS2
DD1591_RS09160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DD1591_RS09185	COG0840	transmembrane signaling receptor activity
DD1591_RS09195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DD1591_RS09195	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DD1591_RS09200	COG3008	intermembrane lipid transfer
DD1591_RS09205	COG2995	paraquat-inducible protein a
DD1591_RS09210	COG1956	GAF domain-containing protein
DD1591_RS09215	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
DD1591_RS09235	COG2197	response regulator
DD1591_RS09240	COG3850	Histidine kinase
DD1591_RS09245	COG2223	nitrite transmembrane transporter activity
DD1591_RS09260	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DD1591_RS09265	COG1140	nitrate reductase beta subunit
DD1591_RS09270	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DD1591_RS09275	COG2181	nitrate reductase activity
DD1591_RS09280	COG1454	alcohol dehydrogenase
DD1591_RS09310	COG1942	4-Oxalocrotonate Tautomerase
DD1591_RS09315	COG3842	ATPase activity
DD1591_RS09325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DD1591_RS09330	COG1012	belongs to the aldehyde dehydrogenase family
DD1591_RS09340	COG1176	ABC-type spermidine putrescine transport system, permease component I
DD1591_RS09350	COG0583	DNA-binding transcription factor activity
DD1591_RS09365	COG1349	DNA-binding transcription factor activity
DD1591_RS09370	COG0483	inositol monophosphate 1-phosphatase activity
DD1591_RS09375	COG2223	nitrite transmembrane transporter activity
DD1591_RS09380	COG0561	phosphatase activity
DD1591_RS09385	COG0840	transmembrane signaling receptor activity
DD1591_RS09390	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
DD1591_RS09395	COG4792	protein secretion
DD1591_RS09405	COG4794	Type iii secretion
DD1591_RS09460	COG2197	response regulator
DD1591_RS09495	COG2951	lytic endotransglycosylase activity
DD1591_RS09545	COG2831	hemolysin activation secretion protein
DD1591_RS09550	COG3210	domain, Protein
DD1591_RS09570	COG0358	DNA primase activity
DD1591_RS09575	COG4974	Belongs to the 'phage' integrase family
DD1591_RS09600	COG0358	DNA primase activity
DD1591_RS09605	COG4974	Belongs to the 'phage' integrase family
DD1591_RS09630	COG3609	addiction module antidote protein, CC2985 family
DD1591_RS09650	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DD1591_RS09660	COG2195	Cleaves the N-terminal amino acid of tripeptides
DD1591_RS09665	COG2850	peptidyl-arginine hydroxylation
DD1591_RS09680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DD1591_RS09685	COG2915	High frequency lysogenization protein hflD homolog
DD1591_RS09690	COG0482	sulfurtransferase activity
DD1591_RS09705	COG0538	isocitrate dehydrogenase activity
DD1591_RS09715	COG0501	Belongs to the peptidase M48B family
DD1591_RS09720	COG0823	Involved in the tonB-independent uptake of proteins
DD1591_RS09735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DD1591_RS09745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DD1591_RS09755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DD1591_RS09760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DD1591_RS09760	COG0072	phenylalanine-tRNA ligase activity
DD1591_RS09765	COG0776	regulation of translation
DD1591_RS09780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DD1591_RS09785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DD1591_RS09790	COG1823	symporter activity
DD1591_RS09795	COG1988	membrane-bound metal-dependent
DD1591_RS09800	COG2755	lipolytic protein G-D-S-L family
DD1591_RS09800	COG0657	acetylesterase activity
DD1591_RS09805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DD1591_RS09810	COG1653	transport
DD1591_RS09815	COG3842	ATPase activity
DD1591_RS09820	COG0395	ABC-type sugar transport system, permease component
DD1591_RS09825	COG1175	transmembrane transport
DD1591_RS09835	COG1028	Short-chain dehydrogenase reductase Sdr
DD1591_RS09840	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DD1591_RS09845	COG1917	Cupin 2, conserved barrel domain protein
DD1591_RS09855	COG3001	Fructosamine kinase
DD1591_RS09870	COG2226	methyltransferase
DD1591_RS09875	COG1971	Probably functions as a manganese efflux pump
DD1591_RS09885	COG3716	PTS system mannose fructose sorbose family IID component
DD1591_RS09890	COG3715	PTS system
DD1591_RS09895	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DD1591_RS09895	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DD1591_RS09900	COG1253	flavin adenine dinucleotide binding
DD1591_RS09905	COG1760	l-serine dehydratase
DD1591_RS09910	COG0494	nUDIX hydrolase
DD1591_RS09925	COG0251	oxidation-reduction process
DD1591_RS09930	COG1199	ATP-dependent helicase activity
DD1591_RS09940	COG3065	identical protein binding
DD1591_RS09945	COG0318	PFAM AMP-dependent synthetase and ligase
DD1591_RS09950	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DD1591_RS09955	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DD1591_RS09960	COG2894	cell division
DD1591_RS09965	COG0850	regulation of cytokinetic process
DD1591_RS09975	COG0179	Fumarylacetoacetate (FAA) hydrolase
DD1591_RS09980	COG2983	Belongs to the UPF0260 family
DD1591_RS09985	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DD1591_RS09990	COG2186	Transcriptional regulator
DD1591_RS09995	COG2719	SpoVR family
DD1591_RS10000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DD1591_RS10005	COG3328	transposase activity
DD1591_RS10035	COG3609	addiction module antidote protein, CC2985 family
DD1591_RS10075	COG5297	Belongs to the glycosyl hydrolase family 6
DD1591_RS10095	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DD1591_RS10100	COG1074	ATP-dependent DNA helicase activity
DD1591_RS10105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DD1591_RS10110	COG0513	Belongs to the DEAD box helicase family
DD1591_RS10115	COG0446	pyridine nucleotide-disulphide oxidoreductase
DD1591_RS10115	COG1902	pentaerythritol trinitrate reductase activity
DD1591_RS10125	COG0583	DNA-binding transcription factor activity
DD1591_RS10135	COG1028	Short-chain dehydrogenase reductase Sdr
DD1591_RS10155	COG3720	iron ion transport
DD1591_RS10165	COG2205	protein histidine kinase activity
DD1591_RS10185	COG4964	Belongs to the GSP D family
DD1591_RS10265	COG1902	pentaerythritol trinitrate reductase activity
DD1591_RS10270	COG1028	Short-chain dehydrogenase reductase Sdr
DD1591_RS10275	COG1028	Short-chain dehydrogenase reductase Sdr
DD1591_RS10290	COG0012	GTP binding
DD1591_RS10295	COG0193	aminoacyl-tRNA hydrolase activity
DD1591_RS10310	COG0583	DNA-binding transcription factor activity
DD1591_RS10320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DD1591_RS10325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DD1591_RS10330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DD1591_RS10335	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DD1591_RS10340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DD1591_RS10345	COG2890	protein-(glutamine-N5) methyltransferase activity
DD1591_RS10355	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DD1591_RS10365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DD1591_RS10370	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DD1591_RS10380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DD1591_RS10385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DD1591_RS10390	COG0840	transmembrane signaling receptor activity
DD1591_RS10415	COG3479	Phenolic acid decarboxylase
DD1591_RS10430	COG3842	ATPase activity
DD1591_RS10450	COG0584	glycerophosphoryl diester phosphodiesterase
DD1591_RS10455	COG0483	inositol monophosphate 1-phosphatase activity
DD1591_RS10495	COG0702	epimerase
DD1591_RS10550	COG4305	rare lipoprotein A
DD1591_RS10555	COG1275	C4-dicarboxylate transporter malic acid transport protein
DD1591_RS10565	COG2315	Protein conserved in bacteria
DD1591_RS10570	COG0583	DNA-binding transcription factor activity
DD1591_RS10580	COG2801	Transposase and inactivated derivatives
DD1591_RS10600	COG1733	regulation of RNA biosynthetic process
DD1591_RS10605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DD1591_RS10615	COG1215	transferase activity, transferring glycosyl groups
DD1591_RS10620	COG4221	oxidoreductase activity
DD1591_RS10630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DD1591_RS10635	COG1940	carbohydrate kinase activity
DD1591_RS10640	COG0583	DNA-binding transcription factor activity
DD1591_RS10645	COG2814	Major facilitator Superfamily
DD1591_RS10655	COG0114	fumarate hydratase activity
DD1591_RS10660	COG1482	cell wall glycoprotein biosynthetic process
DD1591_RS10665	COG5339	Protein conserved in bacteria
DD1591_RS10670	COG1522	sequence-specific DNA binding
DD1591_RS10680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DD1591_RS10690	COG0385	Bile acid
DD1591_RS10695	COG0673	inositol 2-dehydrogenase activity
DD1591_RS10705	COG1172	Belongs to the binding-protein-dependent transport system permease family
DD1591_RS10710	COG1129	ABC transporter
DD1591_RS10715	COG1879	ABC-type sugar transport system periplasmic component
DD1591_RS10720	COG1069	ribulokinase activity
DD1591_RS10725	COG2160	L-arabinose isomerase activity
DD1591_RS10735	COG4657	Part of a membrane complex involved in electron transport
DD1591_RS10740	COG2878	Part of a membrane complex involved in electron transport
DD1591_RS10745	COG4656	Part of a membrane complex involved in electron transport
DD1591_RS10750	COG4658	electron transport chain
DD1591_RS10755	COG4659	FMN binding
DD1591_RS10765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DD1591_RS10770	COG0583	DNA-binding transcription factor activity
DD1591_RS10795	COG0616	signal peptide processing
DD1591_RS10800	COG1028	Short-chain dehydrogenase reductase Sdr
DD1591_RS10805	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DD1591_RS10810	COG1187	pseudouridine synthase activity
DD1591_RS10815	COG0009	L-threonylcarbamoyladenylate synthase
DD1591_RS10820	COG0613	PHP domain protein
DD1591_RS10830	COG0512	Glutamine amidotransferase of anthranilate synthase
DD1591_RS10835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DD1591_RS10840	COG0135	phosphoribosylanthranilate isomerase activity
DD1591_RS10840	COG0134	indole-3-glycerol-phosphate synthase activity
DD1591_RS10845	COG0133	tryptophan synthase activity
DD1591_RS10850	COG0159	tryptophan synthase activity
DD1591_RS10855	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DD1591_RS10860	COG3047	cAMP biosynthetic process
DD1591_RS10870	COG2917	probably involved in intracellular septation
DD1591_RS10885	COG2350	Protein conserved in bacteria
DD1591_RS10895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DD1591_RS10900	COG3099	Belongs to the UPF0263 family
DD1591_RS10910	COG0444	Belongs to the ABC transporter superfamily
DD1591_RS10915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DD1591_RS10930	COG2095	MarC family integral membrane protein
DD1591_RS10935	COG1454	alcohol dehydrogenase
DD1591_RS10935	COG1012	belongs to the aldehyde dehydrogenase family
DD1591_RS10940	COG1435	thymidine kinase activity
DD1591_RS10950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DD1591_RS10955	COG0745	RESPONSE REGULATOR receiver
DD1591_RS10960	COG1752	Esterase of the alpha-beta hydrolase superfamily
DD1591_RS10965	COG3012	SEC-C Motif Domain Protein
DD1591_RS10970	COG0788	formyltetrahydrofolate deformylase activity
DD1591_RS10980	COG2860	membrane
DD1591_RS10985	COG0708	Exodeoxyribonuclease III
DD1591_RS10995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DD1591_RS11000	COG0778	Nitroreductase
DD1591_RS11005	COG0616	signal peptide processing
DD1591_RS11010	COG0252	asparaginase activity
DD1591_RS11015	COG1335	isochorismatase
DD1591_RS11020	COG3139	Protein of unknown function (DUF1315)
DD1591_RS11025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DD1591_RS11045	COG0656	L-ascorbic acid biosynthetic process
DD1591_RS11050	COG3713	MltA-interacting MipA family protein
DD1591_RS11055	COG2766	serine protein kinase
DD1591_RS11060	COG2718	Belongs to the UPF0229 family
DD1591_RS11065	COG0444	Belongs to the ABC transporter superfamily
DD1591_RS11075	COG0747	negative chemotaxis
DD1591_RS11085	COG2261	transglycosylase associated protein
DD1591_RS11125	COG1528	Iron-storage protein
DD1591_RS11130	COG1276	copper resistance
DD1591_RS11135	COG2372	response to copper ion
DD1591_RS11145	COG1770	oligopeptidase
DD1591_RS11150	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DD1591_RS11155	COG0800	Aldolase
DD1591_RS11160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DD1591_RS11165	COG1737	Transcriptional regulator
DD1591_RS11170	COG0469	pyruvate kinase activity
DD1591_RS11180	COG1560	Kdo2-lipid A biosynthetic process
DD1591_RS11185	COG0739	heme binding
DD1591_RS11190	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
DD1591_RS11195	COG1121	(ABC) transporter
DD1591_RS11200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DD1591_RS11205	COG2255	four-way junction helicase activity
DD1591_RS11210	COG0632	four-way junction helicase activity
DD1591_RS11215	COG3385	transposase activity
DD1591_RS11230	COG0217	transcriptional regulatory protein
DD1591_RS11235	COG0494	nUDIX hydrolase
DD1591_RS11240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DD1591_RS11245	COG1801	Protein of unknown function DUF72
DD1591_RS11250	COG3788	relative of glutathione S-transferase, MAPEG superfamily
DD1591_RS11255	COG2226	methyltransferase
DD1591_RS11260	COG0500	methyltransferase
DD1591_RS11270	COG3142	Participates in the control of copper homeostasis
DD1591_RS11275	COG3102	Protein conserved in bacteria
DD1591_RS11280	COG0018	arginyl-trna synthetase
DD1591_RS11300	COG3132	Protein of unknown function, DUF480
DD1591_RS11305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DD1591_RS11310	COG0477	Major facilitator Superfamily
DD1591_RS11315	COG2999	glutathione oxidoreductase activity
DD1591_RS11325	COG3381	protein complex oligomerization
DD1591_RS11350	COG2207	Transcriptional regulator
DD1591_RS11355	COG1902	pentaerythritol trinitrate reductase activity
DD1591_RS11360	COG1028	Short-chain dehydrogenase reductase Sdr
DD1591_RS11385	COG1349	DNA-binding transcription factor activity
DD1591_RS11390	COG0494	nUDIX hydrolase
DD1591_RS11400	COG0494	nUDIX hydrolase
DD1591_RS11410	COG1733	regulation of RNA biosynthetic process
DD1591_RS11415	COG2132	Multicopper oxidase
DD1591_RS11430	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DD1591_RS11435	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
DD1591_RS11440	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
DD1591_RS11445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DD1591_RS11450	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DD1591_RS11455	COG3173	Aminoglycoside phosphotransferase
DD1591_RS11465	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DD1591_RS11470	COG2835	tetraacyldisaccharide 4'-kinase activity
DD1591_RS11475	COG1663	tetraacyldisaccharide 4'-kinase activity
DD1591_RS11480	COG1132	(ABC) transporter
DD1591_RS11485	COG2333	competence protein COMEC
DD1591_RS11485	COG0658	competence protein
DD1591_RS11495	COG2926	Belongs to the UPF0265 family
DD1591_RS11500	COG2925	Exonuclease
DD1591_RS11505	COG0531	amino acid
DD1591_RS11515	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DD1591_RS11520	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DD1591_RS11525	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DD1591_RS11525	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
DD1591_RS11540	COG3052	prosthetic group binding
DD1591_RS11550	COG0179	Fumarylacetoacetate (FAA) hydrolase
DD1591_RS11555	COG3493	citrate carrier protein
DD1591_RS11570	COG0840	transmembrane signaling receptor activity
DD1591_RS11575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DD1591_RS11580	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DD1591_RS11585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DD1591_RS11590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DD1591_RS11595	COG0131	Imidazoleglycerol-phosphate dehydratase
DD1591_RS11595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DD1591_RS11600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DD1591_RS11605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DD1591_RS11610	COG0107	imidazoleglycerol-phosphate synthase activity
DD1591_RS11615	COG0140	phosphoribosyl-ATP diphosphatase activity
DD1591_RS11615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DD1591_RS11625	COG0776	regulation of translation
DD1591_RS11630	COG0539	negative regulation of cytoplasmic translation
DD1591_RS11635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DD1591_RS11640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DD1591_RS11645	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DD1591_RS11650	COG1944	ATP diphosphatase activity
DD1591_RS11655	COG2116	formate transmembrane transporter activity
DD1591_RS11660	COG1882	Formate acetyltransferase
DD1591_RS11670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DD1591_RS11685	COG2814	Major facilitator Superfamily
DD1591_RS11690	COG0583	DNA-binding transcription factor activity
DD1591_RS11705	COG3381	protein complex oligomerization
DD1591_RS11710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DD1591_RS11720	COG3328	transposase activity
DD1591_RS11725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DD1591_RS11730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DD1591_RS11735	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DD1591_RS11740	COG1674	ftsk spoiiie
DD1591_RS11740	COG3107	peptidoglycan biosynthetic process
DD1591_RS11750	COG0492	ferredoxin-NADP+ reductase activity
DD1591_RS11755	COG4988	ABC transporter
DD1591_RS11760	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DD1591_RS11765	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DD1591_RS11770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DD1591_RS11775	COG0542	response to heat
DD1591_RS11780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DD1591_RS11785	COG1278	Cold shock
DD1591_RS11790	COG3593	DNA synthesis involved in DNA repair
DD1591_RS11795	COG1151	hydroxylamine reductase activity
DD1591_RS11800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DD1591_RS11805	COG0702	epimerase
DD1591_RS11810	COG3023	N-Acetylmuramoyl-L-alanine amidase
DD1591_RS11815	COG0393	Putative heavy-metal-binding
DD1591_RS11820	COG1126	abc transporter atp-binding protein
DD1591_RS11825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DD1591_RS11830	COG4215	(ABC) transporter
DD1591_RS11835	COG4160	amino acid transport
DD1591_RS11840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DD1591_RS11855	COG1177	transmembrane transport
DD1591_RS11860	COG1176	ABC-type spermidine putrescine transport system, permease component I
DD1591_RS11865	COG3842	ATPase activity
DD1591_RS11870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DD1591_RS11880	COG0189	ligase activity
DD1591_RS11900	COG2985	domain, Protein
DD1591_RS11900	COG0569	domain protein
DD1591_RS11905	COG1349	DNA-binding transcription factor activity
DD1591_RS11910	COG1686	Belongs to the peptidase S11 family
DD1591_RS11915	COG2267	carboxylic ester hydrolase activity
DD1591_RS11920	COG2011	ABC-type metal ion transport system permease component
DD1591_RS11925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DD1591_RS11930	COG1464	Belongs to the NlpA lipoprotein family
DD1591_RS11935	COG0625	glutathione transferase activity
DD1591_RS11940	COG2133	pyrroloquinoline quinone binding
DD1591_RS11945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DD1591_RS11950	COG2949	membrane
DD1591_RS11955	COG2311	Membrane
DD1591_RS11960	COG0302	gtp cyclohydrolase
DD1591_RS11975	COG0840	transmembrane signaling receptor activity
DD1591_RS11980	COG0840	transmembrane signaling receptor activity
DD1591_RS11985	COG0583	DNA-binding transcription factor activity
DD1591_RS12010	COG0371	Dehydrogenase
DD1591_RS12015	COG1129	ABC transporter
DD1591_RS12020	COG1172	Belongs to the binding-protein-dependent transport system permease family
DD1591_RS12030	COG0833	amino acid
DD1591_RS12035	COG0583	DNA-binding transcription factor activity
DD1591_RS12040	COG2855	membrane
DD1591_RS12045	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DD1591_RS12055	COG3385	transposase activity
DD1591_RS12060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DD1591_RS12060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DD1591_RS12060	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DD1591_RS12065	COG1105	Belongs to the carbohydrate kinase PfkB family
DD1591_RS12085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DD1591_RS12090	COG0523	cobalamin synthesis protein
DD1591_RS12095	COG0791	NLP P60 protein
DD1591_RS12100	COG4166	transmembrane transport
DD1591_RS12105	COG4174	ABC transporter (Permease)
DD1591_RS12110	COG4239	(ABC) transporter, permease
DD1591_RS12115	COG4172	Belongs to the ABC transporter superfamily
DD1591_RS12125	COG2814	Major facilitator Superfamily
DD1591_RS12140	COG1061	Type III restriction enzyme res subunit
DD1591_RS12145	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DD1591_RS12150	COG2223	nitrite transmembrane transporter activity
DD1591_RS12155	COG3279	Response regulator of the LytR AlgR family
DD1591_RS12160	COG3275	phosphorelay sensor kinase activity
DD1591_RS12165	COG3081	Nucleoid-associated protein
DD1591_RS12170	COG3082	Protein of unknown function (DUF1414)
DD1591_RS12195	COG0583	DNA-binding transcription factor activity
DD1591_RS12200	COG1028	Short-chain dehydrogenase reductase Sdr
DD1591_RS12220	COG0386	Belongs to the glutathione peroxidase family
DD1591_RS12225	COG1403	HNH endonuclease
DD1591_RS12240	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DD1591_RS12280	COG3136	membrane protein required for alginate biosynthesis
DD1591_RS12285	COG4677	pectinesterase activity
DD1591_RS12300	COG0577	efflux transmembrane transporter activity
DD1591_RS12300	COG1136	(ABC) transporter
DD1591_RS12305	COG1136	(ABC) transporter
DD1591_RS12320	COG0071	Belongs to the small heat shock protein (HSP20) family
DD1591_RS12330	COG1984	allophanate hydrolase subunit 2
DD1591_RS12345	COG0511	ligase activity, forming carbon-carbon bonds
DD1591_RS12360	COG2807	transmembrane transport
DD1591_RS12365	COG1846	Transcriptional regulator
DD1591_RS12370	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DD1591_RS12375	COG5006	permease, DMT superfamily
DD1591_RS12380	COG0783	Belongs to the Dps family
DD1591_RS12385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DD1591_RS12390	COG0765	amino acid transport
DD1591_RS12395	COG1126	abc transporter atp-binding protein
DD1591_RS12415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DD1591_RS12430	COG1472	Belongs to the glycosyl hydrolase 3 family
DD1591_RS12435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DD1591_RS12440	COG1349	DNA-binding transcription factor activity
DD1591_RS12450	COG1686	Belongs to the peptidase S11 family
DD1591_RS12465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DD1591_RS12470	COG0747	negative chemotaxis
DD1591_RS12475	COG2195	Cleaves the N-terminal amino acid of tripeptides
DD1591_RS12490	COG0697	spore germination
DD1591_RS12495	COG0513	Belongs to the DEAD box helicase family
DD1591_RS12500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DD1591_RS12505	COG1131	(ABC) transporter
DD1591_RS12510	COG0842	Transport permease protein
DD1591_RS12515	COG0842	Transport permease protein
DD1591_RS12520	COG3568	Endonuclease Exonuclease Phosphatase
DD1591_RS12525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DD1591_RS12535	COG0670	Belongs to the BI1 family
DD1591_RS12555	COG0314	molybdopterin synthase activity
DD1591_RS12560	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DD1591_RS12570	COG0521	Mo-molybdopterin cofactor biosynthetic process
DD1591_RS12575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DD1591_RS12585	COG1294	oxidase, subunit
DD1591_RS12590	COG1271	oxidase subunit
DD1591_RS12600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DD1591_RS12605	COG0556	nucleotide-excision repair
DD1591_RS12610	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DD1591_RS12615	COG2226	methyltransferase
DD1591_RS12620	COG0156	8-amino-7-oxononanoate synthase activity
DD1591_RS12625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DD1591_RS12640	COG1380	Effector of murein hydrolase LrgA
DD1591_RS12645	COG1346	cytolysis
DD1591_RS12655	COG0295	cytidine deaminase activity
DD1591_RS12660	COG0281	malic enzyme
DD1591_RS12665	COG0303	'Molybdopterin
DD1591_RS12675	COG1607	acyl-coa hydrolase
DD1591_RS12680	COG0457	Tetratricopeptide repeat
DD1591_RS12680	COG0463	Glycosyl transferase, family 2
DD1591_RS12690	COG0401	homolog of Blt101
DD1591_RS12720	COG3228	Belongs to the MtfA family
DD1591_RS12735	COG3501	Rhs element vgr protein
DD1591_RS12800	COG2916	Histone family protein nucleoid-structuring protein H-NS
DD1591_RS12820	COG0583	DNA-binding transcription factor activity
DD1591_RS12845	COG0765	amino acid transport
DD1591_RS12850	COG0765	amino acid transport
DD1591_RS12855	COG4221	oxidoreductase activity
DD1591_RS12870	COG0436	Aminotransferase
DD1591_RS12875	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DD1591_RS12880	COG1984	allophanate hydrolase subunit 2
DD1591_RS12890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DD1591_RS12895	COG0697	spore germination
DD1591_RS12905	COG2207	Transcriptional regulator
DD1591_RS12910	COG1979	alcohol dehydrogenase
DD1591_RS12915	COG0803	Belongs to the bacterial solute-binding protein 9 family
DD1591_RS12920	COG1121	(ABC) transporter
DD1591_RS12925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DD1591_RS12930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DD1591_RS12940	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DD1591_RS12950	COG0679	Auxin Efflux Carrier
DD1591_RS12980	COG0784	Response regulator, receiver
DD1591_RS12980	COG0835	chemotaxis
DD1591_RS12995	COG0601	transmembrane transport
DD1591_RS13000	COG1957	nucleoside hydrolase
DD1591_RS13005	COG1957	nucleoside hydrolase
DD1591_RS13010	COG0747	negative chemotaxis
DD1591_RS13030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DD1591_RS13035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DD1591_RS13045	COG3118	belongs to the thioredoxin family
DD1591_RS13060	COG2011	ABC-type metal ion transport system permease component
DD1591_RS13065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DD1591_RS13080	COG3416	Protein conserved in bacteria
DD1591_RS13105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DD1591_RS13125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DD1591_RS13130	COG2199	diguanylate cyclase activity
DD1591_RS13150	COG2801	Transposase and inactivated derivatives
DD1591_RS13160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DD1591_RS13175	COG2211	Major facilitator Superfamily
DD1591_RS13190	COG2864	formate dehydrogenase
DD1591_RS13195	COG0437	4 iron, 4 sulfur cluster binding
DD1591_RS13200	COG0243	molybdopterin cofactor binding
DD1591_RS13200	COG3383	formate dehydrogenase (NAD+) activity
DD1591_RS13220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DD1591_RS13225	COG1120	ATPase activity
DD1591_RS13230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DD1591_RS13235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DD1591_RS13240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DD1591_RS13250	COG4264	IucA IucC family
DD1591_RS13260	COG4264	IucA IucC family
DD1591_RS13265	COG2814	Major facilitator Superfamily
DD1591_RS13270	COG0019	diaminopimelate decarboxylase activity
DD1591_RS13275	COG4264	IucA IucC family
DD1591_RS13285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DD1591_RS13290	COG3639	organic phosphonate transmembrane transporter activity
DD1591_RS13300	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DD1591_RS13310	COG0583	DNA-binding transcription factor activity
DD1591_RS13315	COG0667	Aldo Keto reductase
DD1591_RS13320	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DD1591_RS13325	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
DD1591_RS13330	COG3454	Phosphonate metabolism
DD1591_RS13335	COG4778	phosphonate C-P lyase system protein PhnL
DD1591_RS13340	COG4107	phosphonate C-P lyase system protein PhnK
DD1591_RS13345	COG3627	carbon phosphorus lyase activity
DD1591_RS13350	COG3626	phosphonate metabolism
DD1591_RS13355	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
DD1591_RS13360	COG3624	Phosphonate C-P lyase system protein PhnG
DD1591_RS13365	COG2188	Transcriptional regulator
DD1591_RS13370	COG3157	Type VI secretion system effector, Hcp
DD1591_RS13390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DD1591_RS13395	COG1012	belongs to the aldehyde dehydrogenase family
DD1591_RS13400	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DD1591_RS13405	COG0673	inositol 2-dehydrogenase activity
DD1591_RS13410	COG1301	dicarboxylic acid transport
DD1591_RS13415	COG0583	DNA-binding transcription factor activity
DD1591_RS13420	COG0298	carbon dioxide binding
DD1591_RS13425	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DD1591_RS13430	COG0651	ATP synthesis coupled electron transport
DD1591_RS13435	COG0650	Formate hydrogenlyase subunit 4
DD1591_RS13440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DD1591_RS13445	COG4237	Hydrogenase 4 membrane
DD1591_RS13450	COG0651	ATP synthesis coupled electron transport
DD1591_RS13455	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
DD1591_RS13455	COG3261	NADH dehydrogenase
DD1591_RS13460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DD1591_RS13465	COG3260	NADH ubiquinone oxidoreductase 20
DD1591_RS13475	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DD1591_RS13490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DD1591_RS13495	COG3383	formate dehydrogenase (NAD+) activity
DD1591_RS13515	COG1301	dicarboxylic acid transport
DD1591_RS13520	COG1309	transcriptional regulator
DD1591_RS13530	COG0583	DNA-binding transcription factor activity
DD1591_RS13540	COG1609	Transcriptional regulator
DD1591_RS13545	COG3250	beta-galactosidase activity
DD1591_RS13560	COG3386	PFAM SMP-30 Gluconolaconase
DD1591_RS13580	COG2207	Transcriptional regulator
DD1591_RS13590	COG1064	alcohol dehydrogenase
DD1591_RS13640	COG3615	Tellurite resistance protein tehB
DD1591_RS13660	COG1846	Transcriptional regulator
DD1591_RS13665	COG1124	(ABC) transporter
DD1591_RS13670	COG0444	Belongs to the ABC transporter superfamily
DD1591_RS13675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DD1591_RS13680	COG0601	transmembrane transport
DD1591_RS13685	COG0747	negative chemotaxis
DD1591_RS13690	COG2226	methyltransferase
DD1591_RS13695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DD1591_RS13705	COG1346	cytolysis
DD1591_RS13715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DD1591_RS13720	COG0247	lactate metabolic process
DD1591_RS13725	COG1139	Iron-sulfur cluster binding protein
DD1591_RS13730	COG1556	Lactate utilization protein
DD1591_RS13735	COG0488	(ABC) transporter
DD1591_RS13740	COG0730	response to heat
DD1591_RS13750	COG0745	RESPONSE REGULATOR receiver
DD1591_RS13760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DD1591_RS13775	COG0583	DNA-binding transcription factor activity
DD1591_RS13785	COG0477	Major facilitator Superfamily
DD1591_RS13790	COG3813	Protein conserved in bacteria
DD1591_RS13805	COG0672	)-iron permease
DD1591_RS13810	COG4251	negative regulation of phosphorylation
DD1591_RS13810	COG2203	Gaf domain
DD1591_RS13810	COG3706	GGDEF domain
DD1591_RS13810	COG5001	Diguanylate cyclase
DD1591_RS13820	COG4948	Mandelate Racemase Muconate Lactonizing
DD1591_RS13870	COG3829	transcription factor binding
DD1591_RS13925	COG1473	amidohydrolase
DD1591_RS13945	COG3209	COG3209 Rhs family protein
DD1591_RS14005	COG3501	Rhs element vgr protein
DD1591_RS14015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DD1591_RS14025	COG0783	Belongs to the Dps family
DD1591_RS14030	COG2706	6-phosphogluconolactonase activity
DD1591_RS14040	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DD1591_RS14045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DD1591_RS14050	COG4558	Periplasmic binding protein
DD1591_RS14055	COG3720	iron ion transport
DD1591_RS14060	COG2990	Protein conserved in bacteria
DD1591_RS14090	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DD1591_RS14115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DD1591_RS14145	COG2244	polysaccharide biosynthetic process
DD1591_RS14150	COG1215	transferase activity, transferring glycosyl groups
DD1591_RS14170	COG1088	dTDP-glucose 4,6-dehydratase activity
DD1591_RS14215	COG1253	flavin adenine dinucleotide binding
DD1591_RS14220	COG2982	Protein involved in outer membrane biogenesis
DD1591_RS14225	COG0717	Belongs to the dCTP deaminase family
DD1591_RS14235	COG0489	protein tyrosine kinase activity
DD1591_RS14240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DD1591_RS14240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DD1591_RS14245	COG3385	transposase activity
DD1591_RS14265	COG2706	6-phosphogluconolactonase activity
DD1591_RS14270	COG0561	phosphatase activity
DD1591_RS14275	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DD1591_RS14280	COG4149	molybdate abc transporter
DD1591_RS14285	COG0725	ABC transporter, periplasmic molybdate-binding protein
DD1591_RS14295	COG3585	molybdate ion transport
DD1591_RS14295	COG2005	Transcriptional regulator
DD1591_RS14300	COG1119	ATPase activity
DD1591_RS14305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DD1591_RS14310	COG1085	galactose-1-phosphate uridylyltransferase
DD1591_RS14315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DD1591_RS14320	COG2017	converts alpha-aldose to the beta-anomer
DD1591_RS14340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DD1591_RS14345	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DD1591_RS14350	COG0588	phosphoglycerate mutase activity
DD1591_RS14355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DD1591_RS14370	COG1811	Na channel or pump
DD1591_RS14385	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DD1591_RS14390	COG2885	chlorophyll binding
DD1591_RS14395	COG0823	Involved in the tonB-independent uptake of proteins
DD1591_RS14400	COG3064	Membrane
DD1591_RS14405	COG0848	biopolymer transport protein
DD1591_RS14410	COG0811	peptide transport
DD1591_RS14415	COG0824	Thioesterase
DD1591_RS14420	COG3790	cyd operon protein YbgE
DD1591_RS14425	COG1294	oxidase, subunit
DD1591_RS14430	COG1271	oxidase subunit
DD1591_RS14435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DD1591_RS14440	COG0045	succinate-CoA ligase (ADP-forming) activity
DD1591_RS14445	COG0508	dehydrogenase complex catalyzes the overall conversion of
DD1591_RS14450	COG0567	Dehydrogenase, E1 component
DD1591_RS14455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DD1591_RS14460	COG1053	succinate dehydrogenase
DD1591_RS14465	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DD1591_RS14475	COG0372	Belongs to the citrate synthase family
DD1591_RS14480	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DD1591_RS14485	COG1984	allophanate hydrolase subunit 2
DD1591_RS14490	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DD1591_RS14495	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DD1591_RS14500	COG0415	Belongs to the DNA photolyase family
DD1591_RS14505	COG3272	Protein of unknown function (DUF1722)
DD1591_RS14520	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DD1591_RS14525	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DD1591_RS14530	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DD1591_RS14535	COG2205	protein histidine kinase activity
DD1591_RS14540	COG0745	RESPONSE REGULATOR receiver
DD1591_RS14550	COG0033	Phosphoglucomutase
DD1591_RS14560	COG0596	Alpha beta hydrolase
DD1591_RS14570	COG0840	transmembrane signaling receptor activity
DD1591_RS14575	COG0716	FMN binding
DD1591_RS14580	COG0735	belongs to the Fur family
DD1591_RS14585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DD1591_RS14590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DD1591_RS14590	COG1263	PTS System
DD1591_RS14590	COG2190	(PTS) system
DD1591_RS14595	COG0363	glucosamine-6-phosphate deaminase activity
DD1591_RS14600	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DD1591_RS14605	COG1846	Transcriptional regulator
DD1591_RS14605	COG1940	carbohydrate kinase activity
DD1591_RS14610	COG0367	asparagine synthase
DD1591_RS14650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DD1591_RS14655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DD1591_RS14660	COG1702	phosphate starvation-inducible protein PhoH
DD1591_RS14665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DD1591_RS14670	COG4535	Mg2 and Co2 transporter CorC
DD1591_RS14675	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DD1591_RS14685	COG0765	amino acid transport
DD1591_RS14690	COG0765	amino acid transport
DD1591_RS14695	COG1126	abc transporter atp-binding protein
DD1591_RS14700	COG2888	peptidyl-tyrosine sulfation
DD1591_RS14705	COG0495	leucyl-tRNA aminoacylation
DD1591_RS14710	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DD1591_RS14715	COG1466	dna polymerase III delta subunit
DD1591_RS14720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DD1591_RS14725	COG0799	negative regulation of ribosome biogenesis
DD1591_RS14730	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DD1591_RS14735	COG0768	penicillin binding
DD1591_RS14740	COG0772	Belongs to the SEDS family
DD1591_RS14745	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DD1591_RS14750	COG1686	Belongs to the peptidase S11 family
DD1591_RS14755	COG2921	Belongs to the UPF0250 family
DD1591_RS14760	COG0321	lipoyl(octanoyl) transferase activity
DD1591_RS14765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DD1591_RS14770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DD1591_RS14775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DD1591_RS14780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DD1591_RS14790	COG1393	Belongs to the ArsC family
DD1591_RS14795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DD1591_RS14800	COG1876	peptidase activity
DD1591_RS14810	COG0400	carboxylic ester hydrolase activity
DD1591_RS14815	COG1444	tRNA N-acetyltransferase activity
DD1591_RS14820	COG2707	UPF0756 membrane protein
DD1591_RS14825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DD1591_RS14830	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DD1591_RS14840	COG2716	regulation of RNA biosynthetic process
DD1591_RS14845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DD1591_RS14850	COG4783	chaperone-mediated protein folding
DD1591_RS14855	COG1393	Belongs to the ArsC family
DD1591_RS14860	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DD1591_RS14865	COG2233	PERMEase
DD1591_RS14870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DD1591_RS14875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DD1591_RS14880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DD1591_RS14910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DD1591_RS14915	COG0765	amino acid transport
DD1591_RS14920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DD1591_RS14930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DD1591_RS14935	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DD1591_RS14940	COG4181	ATPase activity
DD1591_RS14945	COG2755	lipolytic protein G-D-S-L family
DD1591_RS14950	COG0300	oxidoreductase activity
DD1591_RS14955	COG3118	belongs to the thioredoxin family
DD1591_RS14975	COG1441	menaquinone biosynthetic process
DD1591_RS14985	COG0596	Alpha beta hydrolase
DD1591_RS14990	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DD1591_RS14995	COG1169	isochorismate synthase
DD1591_RS15005	COG2198	Histidine kinase
DD1591_RS15005	COG0642	Histidine kinase
DD1591_RS15015	COG2205	protein histidine kinase activity
DD1591_RS15015	COG0784	Response regulator, receiver
DD1591_RS15025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DD1591_RS15030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DD1591_RS15035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DD1591_RS15040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DD1591_RS15045	COG0330	HflC and HflK could
DD1591_RS15050	COG1585	Membrane protein implicated in regulation of membrane protease activity
DD1591_RS15060	COG2217	Heavy metal translocating P-type atpase
DD1591_RS15065	COG3735	TraB family
DD1591_RS15090	COG0737	Belongs to the 5'-nucleotidase family
DD1591_RS15095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DD1591_RS15095	COG4651	solute:proton antiporter activity
DD1591_RS15100	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DD1591_RS15105	COG0563	adenylate kinase activity
DD1591_RS15110	COG0326	Molecular chaperone. Has ATPase activity
DD1591_RS15115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DD1591_RS15120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DD1591_RS15130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DD1591_RS15135	COG2832	Protein of unknown function (DUF454)
DD1591_RS15150	COG3264	Mechanosensitive ion channel
DD1591_RS15150	COG1196	nuclear chromosome segregation
DD1591_RS15155	COG1309	transcriptional regulator
DD1591_RS15160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DD1591_RS15165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DD1591_RS15170	COG0254	rRNA binding
DD1591_RS15175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DD1591_RS15190	COG3695	enzyme binding
DD1591_RS15195	COG3126	Type III secretion system lipoprotein chaperone (YscW)
DD1591_RS15200	COG1946	Acyl-CoA thioesterase
DD1591_RS15205	COG0004	ammonium transporteR
DD1591_RS15210	COG0347	Belongs to the P(II) protein family
DD1591_RS15215	COG1132	(ABC) transporter
DD1591_RS15220	COG1132	(ABC) transporter
DD1591_RS15225	COG1522	sequence-specific DNA binding
DD1591_RS15235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DD1591_RS15240	COG1555	photosystem II stabilization
DD1591_RS15245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DD1591_RS15250	COG0776	regulation of translation
DD1591_RS15255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DD1591_RS15260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DD1591_RS15270	COG0544	peptidyl-prolyl cis-trans isomerase activity
DD1591_RS15275	COG0271	Belongs to the BolA IbaG family
DD1591_RS15280	COG3056	Lipoprotein
DD1591_RS15285	COG2223	nitrite transmembrane transporter activity
DD1591_RS15290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DD1591_RS15295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DD1591_RS15300	COG1845	cytochrome c oxidase, subunit III
DD1591_RS15305	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DD1591_RS15310	COG0109	protoheme IX farnesyltransferase activity
DD1591_RS15315	COG2814	Major facilitator Superfamily
DD1591_RS15320	COG1666	GTP binding
DD1591_RS15325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DD1591_RS15330	COG0693	protein deglycase activity
DD1591_RS15335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DD1591_RS15335	COG0301	tRNA thio-modification
DD1591_RS15340	COG1722	exodeoxyribonuclease VII activity
DD1591_RS15345	COG0142	geranyltranstransferase activity
DD1591_RS15350	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DD1591_RS15355	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DD1591_RS15360	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DD1591_RS15365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DD1591_RS15370	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DD1591_RS15375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DD1591_RS15375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DD1591_RS15380	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DD1591_RS15385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DD1591_RS15390	COG4238	major outer membrane lipoprotein
DD1591_RS15395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DD1591_RS15400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DD1591_RS15405	COG1862	Preprotein translocase
DD1591_RS15410	COG0343	queuine tRNA-ribosyltransferase activity
DD1591_RS15415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DD1591_RS15420	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
DD1591_RS15425	COG0450	alkyl hydroperoxide reductase
DD1591_RS15440	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DD1591_RS15450	COG5002	protein histidine kinase activity
DD1591_RS15460	COG0420	3'-5' exonuclease activity
DD1591_RS15465	COG0419	ATPase involved in DNA repair
DD1591_RS15470	COG1940	carbohydrate kinase activity
DD1591_RS15475	COG2974	May be involved in recombination
DD1591_RS15485	COG3123	guanosine phosphorylase activity
DD1591_RS15500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DD1591_RS15540	COG0583	DNA-binding transcription factor activity
DD1591_RS15565	COG3706	GGDEF domain
DD1591_RS15570	COG2824	Alkylphosphonate utilization operon protein PhnA
DD1591_RS15585	COG0546	phosphoglycolate phosphatase activity
DD1591_RS15595	COG1881	PFAM PEBP family protein
DD1591_RS15620	COG1846	Transcriptional regulator
DD1591_RS15625	COG2085	NADP oxidoreductase coenzyme F420-dependent
DD1591_RS15630	COG0778	Nitroreductase
DD1591_RS15640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DD1591_RS15645	COG3015	lipoprotein NlpE involved in copper resistance
DD1591_RS15650	COG4681	YaeQ
DD1591_RS15660	COG4568	rho-dependent transcription termination
DD1591_RS15665	COG0037	tRNA processing
DD1591_RS15670	COG0346	lactoylglutathione lyase activity
DD1591_RS15675	COG0825	malonyl-CoA metabolic process
DD1591_RS15680	COG0587	DNA-directed DNA polymerase activity
DD1591_RS15685	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DD1591_RS15690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DD1591_RS15695	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DD1591_RS15700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DD1591_RS15705	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DD1591_RS15710	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
DD1591_RS15715	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DD1591_RS15720	COG0750	zinc metalloprotease
DD1591_RS15725	COG0575	Belongs to the CDS family
DD1591_RS15730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DD1591_RS15735	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DD1591_RS15740	COG0233	cytoplasmic translational termination
DD1591_RS15750	COG0528	UMP kinase activity
DD1591_RS15755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DD1591_RS15770	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DD1591_RS15775	COG2171	N-acyltransferase activity
DD1591_RS15805	COG1611	Belongs to the LOG family
DD1591_RS15810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DD1591_RS15815	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DD1591_RS15820	COG2363	Small membrane protein
DD1591_RS15825	COG0583	DNA-binding transcription factor activity
DD1591_RS15835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DD1591_RS15840	COG2166	iron-sulfur cluster assembly
DD1591_RS15845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DD1591_RS15855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DD1591_RS15865	COG0456	acetyltransferase
DD1591_RS15870	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DD1591_RS15885	COG0860	N-Acetylmuramoyl-L-alanine amidase
DD1591_RS15890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DD1591_RS15890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DD1591_RS15915	COG2165	general secretion pathway protein
DD1591_RS15920	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DD1591_RS15925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DD1591_RS15935	COG0494	nUDIX hydrolase
DD1591_RS15940	COG3066	DNA modification
DD1591_RS15945	COG0861	Integral membrane protein TerC family
DD1591_RS15955	COG0667	Aldo Keto reductase
DD1591_RS15965	COG3171	Protein conserved in bacteria
DD1591_RS15970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DD1591_RS15985	COG0741	lytic transglycosylase activity
DD1591_RS15995	COG1982	Orn Lys Arg decarboxylase major
DD1591_RS16005	COG3477	response to acidic pH
DD1591_RS16035	COG1733	regulation of RNA biosynthetic process
DD1591_RS16055	COG5002	protein histidine kinase activity
DD1591_RS16060	COG0745	RESPONSE REGULATOR receiver
DD1591_RS16085	COG2862	Uncharacterized protein family, UPF0114
DD1591_RS16095	COG1028	Short-chain dehydrogenase reductase Sdr
DD1591_RS16110	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DD1591_RS16110	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DD1591_RS16115	COG0583	DNA-binding transcription factor activity
DD1591_RS16120	COG0473	3-isopropylmalate dehydrogenase activity
DD1591_RS16135	COG1653	transport
DD1591_RS16140	COG1175	transmembrane transport
DD1591_RS16155	COG1234	tRNA 3'-trailer cleavage
DD1591_RS16160	COG1609	Transcriptional regulator
DD1591_RS16170	COG0657	acetylesterase activity
DD1591_RS16175	COG0437	4 iron, 4 sulfur cluster binding
DD1591_RS16180	COG3301	Polysulphide reductase, NrfD
DD1591_RS16185	COG0477	Major facilitator Superfamily
DD1591_RS16225	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DD1591_RS16225	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DD1591_RS16230	COG3604	Transcriptional regulator
DD1591_RS16235	COG0426	domain, Protein
DD1591_RS16235	COG1773	rubredoxin
DD1591_RS16240	COG0446	pyridine nucleotide-disulphide oxidoreductase
DD1591_RS16250	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DD1591_RS16260	COG0531	amino acid
DD1591_RS16265	COG3115	cell septum assembly
DD1591_RS16270	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
DD1591_RS16275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DD1591_RS16280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DD1591_RS16285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DD1591_RS16290	COG2190	(PTS) system
DD1591_RS16295	COG1733	regulation of RNA biosynthetic process
DD1591_RS16305	COG2205	protein histidine kinase activity
DD1591_RS16310	COG0745	RESPONSE REGULATOR receiver
DD1591_RS16325	COG2837	iron assimilation
DD1591_RS16355	COG4178	(ABC) transporter
DD1591_RS16360	COG0612	Peptidase, M16
DD1591_RS16365	COG4771	TonB-dependent receptor
DD1591_RS16370	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DD1591_RS16375	COG0456	acetyltransferase
DD1591_RS16380	COG0408	coproporphyrinogen oxidase activity
DD1591_RS16385	COG1671	Belongs to the UPF0178 family
DD1591_RS16395	COG0494	nUDIX hydrolase
DD1591_RS16400	COG1914	H( )-stimulated, divalent metal cation uptake system
DD1591_RS16405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DD1591_RS16410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DD1591_RS16415	COG0497	DNA recombination
DD1591_RS16425	COG2914	Belongs to the UPF0125 (RnfH) family
DD1591_RS16430	COG2867	negative regulation of translational initiation
DD1591_RS16455	COG3866	Pectate lyase
DD1591_RS16485	COG2165	general secretion pathway protein
DD1591_RS16495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DD1591_RS16510	COG0534	Mate efflux family protein
DD1591_RS16535	COG4221	oxidoreductase activity
DD1591_RS16540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DD1591_RS16545	COG0300	oxidoreductase activity
DD1591_RS16550	COG1733	regulation of RNA biosynthetic process
DD1591_RS16575	COG2951	lytic endotransglycosylase activity
DD1591_RS16585	COG3718	enzyme involved in inositol metabolism
DD1591_RS16595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DD1591_RS16600	COG0673	inositol 2-dehydrogenase activity
DD1591_RS16605	COG1172	Belongs to the binding-protein-dependent transport system permease family
DD1591_RS16620	COG0673	inositol 2-dehydrogenase activity
DD1591_RS16630	COG3962	Belongs to the TPP enzyme family
DD1591_RS16645	COG1181	Belongs to the D-alanine--D-alanine ligase family
DD1591_RS16670	COG2211	Major facilitator Superfamily
DD1591_RS16695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DD1591_RS16695	COG1013	pyruvate-flavodoxin oxidoreductase activity
DD1591_RS16695	COG0674	pyruvate-flavodoxin oxidoreductase activity
DD1591_RS16695	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DD1591_RS16700	COG1376	ErfK ybiS ycfS ynhG family protein
DD1591_RS16710	COG1846	Transcriptional regulator
DD1591_RS16720	COG2814	Major facilitator Superfamily
DD1591_RS16725	COG0246	Mannitol dehydrogenase
DD1591_RS16730	COG3655	Transcriptional regulator
DD1591_RS16745	COG4608	Belongs to the ABC transporter superfamily
DD1591_RS16750	COG0444	Belongs to the ABC transporter superfamily
DD1591_RS16755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DD1591_RS16760	COG0601	transmembrane transport
DD1591_RS16765	COG0747	negative chemotaxis
DD1591_RS16770	COG4948	Mandelate Racemase Muconate Lactonizing
DD1591_RS16780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DD1591_RS16785	COG3162	membrane
DD1591_RS16790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DD1591_RS16795	COG0025	NhaP-type Na H and K H
DD1591_RS16800	COG2252	PERMEase
DD1591_RS16805	COG1560	Kdo2-lipid A biosynthetic process
DD1591_RS16815	COG1175	transmembrane transport
DD1591_RS16820	COG0395	ABC-type sugar transport system, permease component
DD1591_RS16825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DD1591_RS16830	COG3842	ATPase activity
DD1591_RS16840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DD1591_RS16855	COG1733	regulation of RNA biosynthetic process
DD1591_RS16875	COG5433	transposase activity
DD1591_RS16880	COG0438	transferase activity, transferring glycosyl groups
DD1591_RS16890	COG5433	transposase activity
DD1591_RS16930	COG2076	Multidrug Resistance protein
DD1591_RS17005	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DD1591_RS17010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DD1591_RS17015	COG4974	Belongs to the 'phage' integrase family
DD1591_RS17020	COG0477	Major facilitator Superfamily
DD1591_RS17025	COG0716	FMN binding
DD1591_RS17035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DD1591_RS17040	COG0354	folic acid binding
DD1591_RS17045	COG1272	protein, Hemolysin III
DD1591_RS17055	COG1280	lysine exporter protein (LysE YggA)
DD1591_RS17060	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DD1591_RS17060	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DD1591_RS17065	COG0509	glycine decarboxylation via glycine cleavage system
DD1591_RS17070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DD1591_RS17075	COG1454	alcohol dehydrogenase
DD1591_RS17115	COG0583	DNA-binding transcription factor activity
DD1591_RS17120	COG0667	Aldo Keto reductase
DD1591_RS17125	COG2813	Specifically methylates the guanine in position
DD1591_RS17130	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
DD1591_RS17140	COG0813	purine-nucleoside phosphorylase activity
DD1591_RS17145	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DD1591_RS17150	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DD1591_RS17155	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DD1591_RS17160	COG2827	Endonuclease containing a URI domain
DD1591_RS17165	COG3153	acetyltransferase
DD1591_RS17170	COG3154	lipid carrier protein
DD1591_RS17175	COG0826	peptidase U32
DD1591_RS17180	COG0826	peptidase U32
DD1591_RS17185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DD1591_RS17190	COG0513	Belongs to the DEAD box helicase family
DD1591_RS17200	COG1185	polyribonucleotide nucleotidyltransferase activity
DD1591_RS17205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DD1591_RS17210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DD1591_RS17215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DD1591_RS17220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DD1591_RS17225	COG0195	Participates in both transcription termination and antitermination
DD1591_RS17245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DD1591_RS17250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DD1591_RS17255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DD1591_RS17260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DD1591_RS17265	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DD1591_RS17270	COG1534	Rna-binding protein
DD1591_RS17280	COG2027	D-alanyl-D-alanine carboxypeptidase
DD1591_RS17285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DD1591_RS17290	COG0697	spore germination
DD1591_RS17300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DD1591_RS17305	COG0142	geranyltranstransferase activity
DD1591_RS17325	COG1438	arginine binding
DD1591_RS17330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DD1591_RS17335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DD1591_RS17340	COG0358	DNA primase activity
DD1591_RS17345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DD1591_RS17365	COG0667	Aldo Keto reductase
DD1591_RS17390	COG1477	protein flavinylation
DD1591_RS17400	COG3344	reverse transcriptase
DD1591_RS17405	COG3678	ATP-independent chaperone mediated protein folding
DD1591_RS17415	COG2271	Major facilitator Superfamily
DD1591_RS17425	COG2197	response regulator
DD1591_RS17435	COG2813	Specifically methylates the guanine in position
DD1591_RS17440	COG0861	Integral membrane protein TerC family
DD1591_RS17450	COG2721	sulfolactate sulfo-lyase activity
DD1591_RS17455	COG0246	Mannitol dehydrogenase
DD1591_RS17460	COG1904	glucuronate isomerase
DD1591_RS17465	COG2271	Major facilitator Superfamily
DD1591_RS17475	COG0586	Pfam SNARE associated Golgi protein
DD1591_RS17485	COG4575	ribosome binding
DD1591_RS17490	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
DD1591_RS17500	COG2259	Doxx family
DD1591_RS17505	COG0435	Glutathione S-transferase
DD1591_RS17510	COG0583	DNA-binding transcription factor activity
DD1591_RS17515	COG1741	Belongs to the pirin family
DD1591_RS17520	COG0735	belongs to the Fur family
DD1591_RS17525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DD1591_RS17530	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DD1591_RS17535	COG2937	Belongs to the GPAT DAPAT family
DD1591_RS17540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DD1591_RS17545	COG3161	chorismate lyase activity
DD1591_RS17550	COG0459	protein refolding
DD1591_RS17555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DD1591_RS17570	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DD1591_RS17575	COG1324	tolerance protein
DD1591_RS17580	COG4232	protein-disulfide reductase activity
DD1591_RS17585	COG1309	transcriptional regulator
DD1591_RS17595	COG0582	viral genome integration into host DNA
DD1591_RS17640	COG1045	serine acetyltransferase
DD1591_RS17655	COG0297	glycogen (starch) synthase activity
DD1591_RS17655	COG0438	transferase activity, transferring glycosyl groups
DD1591_RS17705	COG1609	Transcriptional regulator
DD1591_RS17760	COG3634	alkyl hydroperoxide reductase activity
DD1591_RS17770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DD1591_RS17780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DD1591_RS17795	COG0840	transmembrane signaling receptor activity
DD1591_RS17805	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DD1591_RS17810	COG2977	Belongs to the P-Pant transferase superfamily
DD1591_RS17815	COG0084	hydrolase, TatD family'
DD1591_RS17825	COG2823	Periplasmic or secreted lipoprotein
DD1591_RS17830	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DD1591_RS17835	COG3726	membrane protein affecting hemolysin expression
DD1591_RS17840	COG0560	Phosphoserine phosphatase
DD1591_RS17855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DD1591_RS17860	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DD1591_RS17865	COG3079	Belongs to the UPF0149 family
DD1591_RS17870	COG0006	proline dipeptidase activity
DD1591_RS17875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DD1591_RS17880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DD1591_RS17905	COG0747	negative chemotaxis
DD1591_RS17915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DD1591_RS17925	COG1917	Cupin 2, conserved barrel domain protein
DD1591_RS17925	COG4977	sequence-specific DNA binding
DD1591_RS17930	COG1917	Cupin 2, conserved barrel domain protein
DD1591_RS17930	COG2169	Transcriptional regulator
DD1591_RS17935	COG1070	Carbohydrate kinase
DD1591_RS17940	COG4806	L-rhamnose isomerase
DD1591_RS17945	COG0235	Class ii aldolase
DD1591_RS17955	COG0840	transmembrane signaling receptor activity
DD1591_RS17960	COG1414	Transcriptional regulator
DD1591_RS17965	COG1418	mRNA catabolic process
DD1591_RS17975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DD1591_RS17980	COG1605	Chorismate mutase
DD1591_RS18020	COG0583	DNA-binding transcription factor activity
DD1591_RS18030	COG4608	Belongs to the ABC transporter superfamily
DD1591_RS18035	COG0444	Belongs to the ABC transporter superfamily
DD1591_RS18040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DD1591_RS18050	COG0747	negative chemotaxis
DD1591_RS18075	COG1028	Short-chain dehydrogenase reductase Sdr
DD1591_RS18080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DD1591_RS18085	COG1172	Belongs to the binding-protein-dependent transport system permease family
DD1591_RS18090	COG1129	ABC transporter
DD1591_RS18100	COG1879	ABC-type sugar transport system periplasmic component
DD1591_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
DD1591_RS18110	COG3958	Transketolase
DD1591_RS18115	COG3959	Transketolase, thiamine diphosphate binding domain
DD1591_RS18120	COG1349	DNA-binding transcription factor activity
DD1591_RS18125	COG1196	nuclear chromosome segregation
DD1591_RS18135	COG2814	Major facilitator Superfamily
DD1591_RS18170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DD1591_RS18175	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DD1591_RS18200	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DD1591_RS18200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DD1591_RS18230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DD1591_RS18230	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DD1591_RS18250	COG1401	restriction endodeoxyribonuclease activity
DD1591_RS18255	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
DD1591_RS18285	COG0697	spore germination
DD1591_RS18380	COG3550	peptidyl-serine autophosphorylation
DD1591_RS18385	COG0582	viral genome integration into host DNA
DD1591_RS18405	COG3423	Transcriptional regulator
DD1591_RS18445	COG0582	viral genome integration into host DNA
DD1591_RS18455	COG0795	lipopolysaccharide-transporting ATPase activity
DD1591_RS18460	COG0795	lipopolysaccharide-transporting ATPase activity
DD1591_RS18465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DD1591_RS18470	COG2927	DNA polymerase III (CHI subunit)
DD1591_RS18475	COG0525	valine-tRNA ligase activity
DD1591_RS18480	COG0840	transmembrane signaling receptor activity
DD1591_RS18485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DD1591_RS18490	COG0454	-acetyltransferase
DD1591_RS18520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DD1591_RS18525	COG2723	6-phospho-beta-galactosidase activity
DD1591_RS18530	COG2731	YhcH YjgK YiaL family protein
DD1591_RS18535	COG0540	Belongs to the ATCase OTCase family
DD1591_RS18540	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
DD1591_RS18570	COG4172	Belongs to the ABC transporter superfamily
DD1591_RS18575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DD1591_RS18580	COG0601	transmembrane transport
DD1591_RS18595	COG1328	CTP reductase activity
DD1591_RS18600	COG0602	queuosine metabolic process
DD1591_RS18610	COG1569	PIN domain
DD1591_RS18615	COG3311	Transcriptional regulator
DD1591_RS18655	COG0848	biopolymer transport protein
DD1591_RS18660	COG0811	peptide transport
DD1591_RS18665	COG0626	cystathionine gamma-synthase activity
DD1591_RS18670	COG0586	Pfam SNARE associated Golgi protein
DD1591_RS18675	COG2207	Transcriptional regulator
DD1591_RS18680	COG1979	alcohol dehydrogenase
DD1591_RS18685	COG0656	L-ascorbic acid biosynthetic process
DD1591_RS18690	COG2132	Multicopper oxidase
DD1591_RS18700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DD1591_RS18705	COG2249	NAD(P)H dehydrogenase (quinone) activity
DD1591_RS18710	COG0583	DNA-binding transcription factor activity
DD1591_RS18720	COG3150	esterase
DD1591_RS18725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DD1591_RS18730	COG3151	Protein conserved in bacteria
DD1591_RS18735	COG0494	nUDIX hydrolase
DD1591_RS18740	COG1538	Outer membrane efflux protein
DD1591_RS18745	COG5463	Belongs to the UPF0441 family
DD1591_RS18750	COG0754	glutathionylspermidine amidase activity
DD1591_RS18755	COG3384	dioxygenase
DD1591_RS18760	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DD1591_RS18765	COG3107	peptidoglycan biosynthetic process
DD1591_RS18770	COG0792	nuclease activity
DD1591_RS18775	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DD1591_RS18780	COG2823	Periplasmic or secreted lipoprotein
DD1591_RS18790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DD1591_RS18795	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DD1591_RS18800	COG0784	Response regulator, receiver
DD1591_RS18800	COG2198	Histidine kinase
DD1591_RS18800	COG5002	protein histidine kinase activity
DD1591_RS18805	COG1242	4 iron, 4 sulfur cluster binding
DD1591_RS18810	COG0067	glutamate synthase
DD1591_RS18810	COG0069	glutamate synthase activity
DD1591_RS18810	COG0070	glutamate synthase
DD1591_RS18815	COG0493	'glutamate synthase
DD1591_RS18825	COG2969	positive regulation of protein catabolic process
DD1591_RS18830	COG0625	glutathione transferase activity
DD1591_RS18840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DD1591_RS18850	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DD1591_RS18855	COG3105	Protein conserved in bacteria
DD1591_RS18860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DD1591_RS18865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DD1591_RS18870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DD1591_RS18875	COG5007	Belongs to the BolA IbaG family
DD1591_RS18880	COG3113	response to antibiotic
DD1591_RS18885	COG2854	intermembrane phospholipid transfer
DD1591_RS18890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DD1591_RS18895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DD1591_RS18900	COG1127	ABC transporter
DD1591_RS18905	COG0530	calcium, potassium:sodium antiporter activity
DD1591_RS18910	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DD1591_RS18910	COG0517	IMP dehydrogenase activity
DD1591_RS18915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DD1591_RS18920	COG3117	lipopolysaccharide transmembrane transporter activity
DD1591_RS18925	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DD1591_RS18930	COG1137	ATPase activity
DD1591_RS18935	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DD1591_RS18950	COG1660	Displays ATPase and GTPase activities
DD1591_RS18955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DD1591_RS18960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DD1591_RS18965	COG0312	modulator of DNA gyrase
DD1591_RS18970	COG3028	Belongs to the UPF0307 family
DD1591_RS18980	COG1289	transmembrane transporter activity
DD1591_RS18985	COG1566	PFAM secretion protein HlyD family protein
DD1591_RS18995	COG0583	DNA-binding transcription factor activity
DD1591_RS19000	COG0312	modulator of DNA gyrase
DD1591_RS19005	COG3164	Protein of unknown function
DD1591_RS19015	COG0424	maF-like protein
DD1591_RS19020	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DD1591_RS19025	COG1792	Involved in formation and maintenance of cell shape
DD1591_RS19030	COG1077	Cell shape determining protein MreB Mrl
DD1591_RS19035	COG2200	EAL domain
DD1591_RS19035	COG2199	diguanylate cyclase activity
DD1591_RS19040	COG0604	alcohol dehydrogenase
DD1591_RS19045	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DD1591_RS19050	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DD1591_RS19055	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DD1591_RS19060	COG0511	ligase activity, forming carbon-carbon bonds
DD1591_RS19065	COG0439	Biotin carboxylase
DD1591_RS19070	COG3924	membrane
DD1591_RS19075	COG4145	pantothenate transmembrane transporter activity
DD1591_RS19080	COG2264	protein methyltransferase activity
DD1591_RS19090	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DD1591_RS19095	COG1064	alcohol dehydrogenase
DD1591_RS19115	COG2814	Major facilitator Superfamily
DD1591_RS19125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DD1591_RS19130	COG0765	amino acid transport
DD1591_RS19135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DD1591_RS19140	COG4597	amino acid ABC transporter
DD1591_RS19145	COG0765	amino acid transport
DD1591_RS19150	COG1126	abc transporter atp-binding protein
DD1591_RS19175	COG0138	bifunctional purine biosynthesis protein purh
DD1591_RS19180	COG0151	Belongs to the GarS family
DD1591_RS19200	COG1515	deoxyribonuclease V activity
DD1591_RS19205	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DD1591_RS19210	COG2816	NAD+ diphosphatase activity
DD1591_RS19215	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
DD1591_RS19220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DD1591_RS19225	COG0352	thiamine-phosphate diphosphorylase activity
DD1591_RS19230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DD1591_RS19235	COG2104	thiamine diphosphate biosynthetic process
DD1591_RS19240	COG2022	thiamine diphosphate biosynthetic process
DD1591_RS19250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DD1591_RS19255	COG5457	Domain of unknown function (DUF1127)
DD1591_RS19305	COG0250	Participates in transcription elongation, termination and antitermination
DD1591_RS19315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DD1591_RS19340	COG1072	(Pantothenic acid kinase))
DD1591_RS19350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DD1591_RS19380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DD1591_RS19385	COG1739	Uncharacterized protein family UPF0029
DD1591_RS19390	COG0006	proline dipeptidase activity
DD1591_RS19395	COG1250	3-hydroxyacyl-CoA dehydrogenase
DD1591_RS19395	COG1024	Enoyl-CoA hydratase
DD1591_RS19400	COG0183	Belongs to the thiolase family
DD1591_RS19420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DD1591_RS19440	COG0084	hydrolase, TatD family'
DD1591_RS19445	COG0805	protein transport
DD1591_RS19455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DD1591_RS19460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DD1591_RS19465	COG3165	ubiquinone biosynthetic process from chorismate
DD1591_RS19470	COG2226	methyltransferase
DD1591_RS19475	COG1322	Protein conserved in bacteria
DD1591_RS19480	COG0165	Argininosuccinate lyase
DD1591_RS19485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DD1591_RS19490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DD1591_RS19495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DD1591_RS19515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DD1591_RS19520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DD1591_RS19525	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DD1591_RS19545	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DD1591_RS19555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DD1591_RS19580	COG1045	serine acetyltransferase
DD1591_RS19585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DD1591_RS19590	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DD1591_RS19595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DD1591_RS19600	COG4942	peptidase
DD1591_RS19605	COG2861	carbohydrate metabolic process
DD1591_RS19610	COG1063	alcohol dehydrogenase
DD1591_RS19615	COG0156	8-amino-7-oxononanoate synthase activity
DD1591_RS19620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DD1591_RS19625	COG0859	PFAM glycosyl transferase family 9
DD1591_RS19635	COG0859	PFAM glycosyl transferase family 9
DD1591_RS19655	COG0438	transferase activity, transferring glycosyl groups
DD1591_RS19660	COG1519	Transferase
DD1591_RS19670	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DD1591_RS19675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DD1591_RS19690	COG2003	Belongs to the UPF0758 family
DD1591_RS19695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DD1591_RS19700	COG0756	dUTP diphosphatase activity
DD1591_RS19705	COG1309	transcriptional regulator
DD1591_RS19710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DD1591_RS19715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DD1591_RS19720	COG2149	membrane
DD1591_RS19735	COG4948	Mandelate Racemase Muconate Lactonizing
DD1591_RS19740	COG4172	Belongs to the ABC transporter superfamily
DD1591_RS19750	COG0601	transmembrane transport
DD1591_RS19755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DD1591_RS19800	COG1136	(ABC) transporter
DD1591_RS19800	COG0577	efflux transmembrane transporter activity
DD1591_RS19805	COG0577	efflux transmembrane transporter activity
DD1591_RS19805	COG1136	(ABC) transporter
DD1591_RS19835	COG4608	Belongs to the ABC transporter superfamily
DD1591_RS19840	COG0444	Belongs to the ABC transporter superfamily
DD1591_RS19845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DD1591_RS19850	COG0601	transmembrane transport
DD1591_RS19855	COG0747	negative chemotaxis
DD1591_RS19865	COG0583	DNA-binding transcription factor activity
DD1591_RS19870	COG1561	YicC-like family, N-terminal region
DD1591_RS19895	COG3561	AntA/AntB antirepressor
DD1591_RS19940	COG3385	transposase activity
DD1591_RS19950	COG3385	transposase activity
DD1591_RS19965	COG2957	Belongs to the agmatine deiminase family
DD1591_RS19970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DD1591_RS19975	COG0205	6-phosphofructokinase activity
DD1591_RS19980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DD1591_RS20045	COG3678	ATP-independent chaperone mediated protein folding
DD1591_RS20050	COG0745	RESPONSE REGULATOR receiver
DD1591_RS20055	COG2205	protein histidine kinase activity
DD1591_RS20075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DD1591_RS20085	COG0679	Auxin Efflux Carrier
DD1591_RS20090	COG0584	glycerophosphoryl diester phosphodiesterase
DD1591_RS20095	COG3842	ATPase activity
DD1591_RS20100	COG0395	ABC-type sugar transport system, permease component
DD1591_RS20110	COG1653	transport
DD1591_RS20115	COG0840	transmembrane signaling receptor activity
DD1591_RS20120	COG0840	transmembrane signaling receptor activity
DD1591_RS20125	COG0840	transmembrane signaling receptor activity
DD1591_RS20145	COG0840	transmembrane signaling receptor activity
DD1591_RS20150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DD1591_RS20165	COG4177	L-phenylalanine transmembrane transporter activity
DD1591_RS20170	COG0559	Belongs to the binding-protein-dependent transport system permease family
DD1591_RS20175	COG0683	leucine binding
DD1591_RS20190	COG2177	Part of the ABC transporter FtsEX involved in
DD1591_RS20195	COG2884	Cell division ATP-binding protein ftsE
DD1591_RS20200	COG0552	protein localization to endoplasmic reticulum
DD1591_RS20200	COG0552	protein localization to endoplasmic reticulum
DD1591_RS20205	COG0742	ribosomal rna small subunit methyltransferase
DD1591_RS20210	COG3776	membrane
DD1591_RS20220	COG0425	Belongs to the sulfur carrier protein TusA family
DD1591_RS20225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DD1591_RS20235	COG0477	Major facilitator Superfamily
DD1591_RS20240	COG1295	ribonuclease BN
DD1591_RS20245	COG1942	4-Oxalocrotonate Tautomerase
DD1591_RS20250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DD1591_RS20265	COG1301	dicarboxylic acid transport
DD1591_RS20270	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DD1591_RS20280	COG0457	Tetratricopeptide repeat
DD1591_RS20285	COG1215	transferase activity, transferring glycosyl groups
DD1591_RS20295	COG0489	protein tyrosine kinase activity
DD1591_RS20340	COG3157	Type VI secretion system effector, Hcp
DD1591_RS20345	COG4608	Belongs to the ABC transporter superfamily
DD1591_RS20350	COG0444	Belongs to the ABC transporter superfamily
DD1591_RS20355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DD1591_RS20360	COG0601	transmembrane transport
DD1591_RS20370	COG0747	negative chemotaxis
DD1591_RS20375	COG3493	citrate carrier protein
DD1591_RS20380	COG3344	reverse transcriptase
DD1591_RS20385	COG4565	transcriptional regulatory protein
DD1591_RS20390	COG3290	protein histidine kinase activity
DD1591_RS20395	COG0471	metal ion transport
DD1591_RS20400	COG0071	Belongs to the small heat shock protein (HSP20) family
DD1591_RS20405	COG0071	Belongs to the small heat shock protein (HSP20) family
DD1591_RS20410	COG5645	(Lipo)protein
DD1591_RS20415	COG0477	Major facilitator Superfamily
DD1591_RS20420	COG0823	Involved in the tonB-independent uptake of proteins
DD1591_RS20440	COG0561	phosphatase activity
DD1591_RS20445	COG0589	response to stress
DD1591_RS20455	COG0306	phosphate transporter
DD1591_RS20460	COG2081	HI0933 family
DD1591_RS20465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DD1591_RS20485	COG3842	ATPase activity
DD1591_RS20490	COG0395	ABC-type sugar transport system, permease component
DD1591_RS20515	COG3048	D-serine ammonia-lyase activity
DD1591_RS20545	COG1175	transmembrane transport
DD1591_RS20555	COG2814	Major facilitator Superfamily
DD1591_RS20590	COG2194	sulfuric ester hydrolase activity
DD1591_RS20595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DD1591_RS20600	COG0194	GDP metabolic process
DD1591_RS20610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DD1591_RS20615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DD1591_RS20620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DD1591_RS20625	COG2233	PERMEase
DD1591_RS20630	COG2982	Protein involved in outer membrane biogenesis
DD1591_RS20635	COG0456	acetyltransferase
DD1591_RS20640	COG1490	D-aminoacyl-tRNA deacylase activity
DD1591_RS20645	COG1011	Hydrolase
DD1591_RS20650	COG1217	gtp-binding protein TYPA
DD1591_RS20660	COG3852	Histidine kinase
DD1591_RS20675	COG3078	GTPase activator activity
DD1591_RS20680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DD1591_RS20685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DD1591_RS20685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DD1591_RS20690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DD1591_RS20695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DD1591_RS20700	COG3084	Protein conserved in bacteria
DD1591_RS20710	COG1763	Mo-molybdopterin cofactor biosynthetic process
DD1591_RS20735	COG1609	Transcriptional regulator
DD1591_RS20740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DD1591_RS20745	COG1879	ABC-type sugar transport system periplasmic component
DD1591_RS20750	COG1172	Belongs to the binding-protein-dependent transport system permease family
DD1591_RS20755	COG1129	ABC transporter
DD1591_RS20760	COG1869	D-ribose catabolic process
DD1591_RS20765	COG3111	PFAM Bacterial OB fold (BOF) protein
DD1591_RS20785	COG3158	transport of potassium into the cell
DD1591_RS20790	COG0714	Associated with various cellular activities
DD1591_RS20795	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DD1591_RS20800	COG1522	sequence-specific DNA binding
DD1591_RS20805	COG0716	FMN binding
DD1591_RS20810	COG0445	tRNA wobble uridine modification
DD1591_RS20815	COG0357	Ribosomal RNA small subunit methyltransferase G
DD1591_RS20825	COG3312	ion transport
DD1591_RS20830	COG0356	it plays a direct role in the translocation of protons across the membrane
DD1591_RS20840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DD1591_RS20845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DD1591_RS20850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DD1591_RS20855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DD1591_RS20860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DD1591_RS20865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DD1591_RS20875	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DD1591_RS20880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DD1591_RS20915	COG0003	Pfam Anion-transporting ATPase
DD1591_RS20925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DD1591_RS20930	COG0573	inorganic phosphate transmembrane transporter activity
DD1591_RS20935	COG0581	inorganic phosphate transmembrane transporter activity
DD1591_RS20940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DD1591_RS20950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DD1591_RS20960	COG0765	amino acid transport
DD1591_RS20965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DD1591_RS20970	COG2252	PERMEase
DD1591_RS20975	COG2091	lysine biosynthetic process via aminoadipic acid
DD1591_RS20980	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DD1591_RS20985	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DD1591_RS20985	COG0493	'glutamate synthase
DD1591_RS21010	COG0463	Glycosyl transferase, family 2
DD1591_RS21020	COG0726	polysaccharide deacetylase
DD1591_RS21025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DD1591_RS21030	COG2076	Multidrug Resistance protein
DD1591_RS21035	COG2076	Multidrug Resistance protein
DD1591_RS21045	COG2910	NAD(P)H-binding
DD1591_RS21050	COG1733	regulation of RNA biosynthetic process
DD1591_RS21060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DD1591_RS21095	COG3645	SOS response
DD1591_RS21100	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
DD1591_RS21105	COG3550	peptidyl-serine autophosphorylation
DD1591_RS21180	COG4974	Belongs to the 'phage' integrase family
DD1591_RS21185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DD1591_RS21190	COG0706	membrane insertase activity
DD1591_RS21195	COG0594	ribonuclease P activity
DD1591_RS21240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DD1591_RS21245	COG3036	rescue of stalled ribosome
DD1591_RS21250	COG0551	DNA topoisomerase type I activity
DD1591_RS21440	COG3209	COG3209 Rhs family protein
DD1591_RS21440	COG4104	PAAR repeat-containing protein
DD1591_RS21465	COG3313	Fe-S protein
DD1591_RS21495	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DD1591_RS21530	COG0727	PFAM Uncharacterised protein family (UPF0153)
DD1591_RS21640	COG3708	Transcriptional regulator
DD1591_RS21640	COG2207	Transcriptional regulator
DD1591_RS21655	COG4890	Cyd operon protein YbgT
DD1591_RS21700	COG3423	Transcriptional regulator
DD1591_RS21770	COG3423	Transcriptional regulator
DD1591_RS21865	COG0583	DNA-binding transcription factor activity
DD1591_RS21930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane