locus-tag	class	description
DDI_RS00005	COG1126	abc transporter atp-binding protein
DDI_RS00010	COG0765	amino acid transport
DDI_RS00015	COG4597	amino acid ABC transporter
DDI_RS00020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDI_RS00025	COG0765	amino acid transport
DDI_RS00030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDI_RS00045	COG3328	transposase activity
DDI_RS00070	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DDI_RS00080	COG2264	protein methyltransferase activity
DDI_RS00085	COG4145	pantothenate transmembrane transporter activity
DDI_RS00090	COG3924	membrane
DDI_RS00095	COG0439	Biotin carboxylase
DDI_RS00100	COG0511	ligase activity, forming carbon-carbon bonds
DDI_RS00105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DDI_RS00110	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DDI_RS00115	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DDI_RS00120	COG0604	alcohol dehydrogenase
DDI_RS00125	COG2199	diguanylate cyclase activity
DDI_RS00125	COG2200	EAL domain
DDI_RS00130	COG1077	Cell shape determining protein MreB Mrl
DDI_RS00135	COG1792	Involved in formation and maintenance of cell shape
DDI_RS00140	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DDI_RS00145	COG0424	maF-like protein
DDI_RS00155	COG3164	Protein of unknown function
DDI_RS00160	COG0312	modulator of DNA gyrase
DDI_RS00165	COG0583	DNA-binding transcription factor activity
DDI_RS00175	COG1566	PFAM secretion protein HlyD family protein
DDI_RS00180	COG1289	transmembrane transporter activity
DDI_RS00190	COG1280	lysine exporter protein (LysE YggA)
DDI_RS00195	COG3028	Belongs to the UPF0307 family
DDI_RS00200	COG0312	modulator of DNA gyrase
DDI_RS00205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DDI_RS00210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DDI_RS00215	COG1660	Displays ATPase and GTPase activities
DDI_RS00230	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DDI_RS00235	COG1137	ATPase activity
DDI_RS00240	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DDI_RS00245	COG3117	lipopolysaccharide transmembrane transporter activity
DDI_RS00250	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DDI_RS00255	COG0517	IMP dehydrogenase activity
DDI_RS00255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DDI_RS00260	COG0530	calcium, potassium:sodium antiporter activity
DDI_RS00265	COG1127	ABC transporter
DDI_RS00270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DDI_RS00275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DDI_RS00280	COG2854	intermembrane phospholipid transfer
DDI_RS00285	COG3113	response to antibiotic
DDI_RS00290	COG5007	Belongs to the BolA IbaG family
DDI_RS00295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DDI_RS00300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DDI_RS00305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DDI_RS00310	COG3105	Protein conserved in bacteria
DDI_RS00315	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DDI_RS00330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DDI_RS00335	COG0625	glutathione transferase activity
DDI_RS00340	COG2969	positive regulation of protein catabolic process
DDI_RS00350	COG0493	'glutamate synthase
DDI_RS00355	COG0069	glutamate synthase activity
DDI_RS00355	COG0070	glutamate synthase
DDI_RS00355	COG0067	glutamate synthase
DDI_RS00360	COG1242	4 iron, 4 sulfur cluster binding
DDI_RS00365	COG0784	Response regulator, receiver
DDI_RS00365	COG5002	protein histidine kinase activity
DDI_RS00365	COG2198	Histidine kinase
DDI_RS00370	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DDI_RS00375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DDI_RS00385	COG2823	Periplasmic or secreted lipoprotein
DDI_RS00390	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DDI_RS00395	COG0792	nuclease activity
DDI_RS00400	COG3107	peptidoglycan biosynthetic process
DDI_RS00405	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DDI_RS00415	COG3384	dioxygenase
DDI_RS00420	COG0754	glutathionylspermidine amidase activity
DDI_RS00425	COG5463	Belongs to the UPF0441 family
DDI_RS00430	COG1538	Outer membrane efflux protein
DDI_RS00435	COG0494	nUDIX hydrolase
DDI_RS00440	COG3151	Protein conserved in bacteria
DDI_RS00445	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DDI_RS00450	COG3150	esterase
DDI_RS00465	COG2249	NAD(P)H dehydrogenase (quinone) activity
DDI_RS00470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DDI_RS00475	COG0204	Acyl-transferase
DDI_RS00480	COG2132	Multicopper oxidase
DDI_RS00485	COG0656	L-ascorbic acid biosynthetic process
DDI_RS00490	COG1979	alcohol dehydrogenase
DDI_RS00495	COG2207	Transcriptional regulator
DDI_RS00500	COG0586	Pfam SNARE associated Golgi protein
DDI_RS00505	COG0626	cystathionine gamma-synthase activity
DDI_RS00515	COG0848	biopolymer transport protein
DDI_RS00520	COG3254	rhamnose metabolic process
DDI_RS00530	COG4806	L-rhamnose isomerase
DDI_RS00535	COG1070	Carbohydrate kinase
DDI_RS00540	COG2169	Transcriptional regulator
DDI_RS00540	COG1917	Cupin 2, conserved barrel domain protein
DDI_RS00545	COG1454	alcohol dehydrogenase
DDI_RS00550	COG0235	Class ii aldolase
DDI_RS00595	COG0602	queuosine metabolic process
DDI_RS00600	COG1328	CTP reductase activity
DDI_RS00615	COG0601	transmembrane transport
DDI_RS00620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS00630	COG3157	Type VI secretion system effector, Hcp
DDI_RS00660	COG2308	Evidence 4 Homologs of previously reported genes of
DDI_RS00690	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
DDI_RS00695	COG0540	Belongs to the ATCase OTCase family
DDI_RS00700	COG2731	YhcH YjgK YiaL family protein
DDI_RS00705	COG2723	6-phospho-beta-galactosidase activity
DDI_RS00710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DDI_RS00735	COG0454	-acetyltransferase
DDI_RS00740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DDI_RS00750	COG1438	arginine binding
DDI_RS00755	COG1288	antiporter activity
DDI_RS00765	COG0549	Belongs to the carbamate kinase family
DDI_RS00775	COG0525	valine-tRNA ligase activity
DDI_RS00780	COG2927	DNA polymerase III (CHI subunit)
DDI_RS00785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DDI_RS00790	COG0795	lipopolysaccharide-transporting ATPase activity
DDI_RS00795	COG0795	lipopolysaccharide-transporting ATPase activity
DDI_RS00805	COG0582	viral genome integration into host DNA
DDI_RS00810	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DDI_RS00825	COG3423	Transcriptional regulator
DDI_RS00950	COG3727	T/G mismatch-specific endonuclease activity
DDI_RS00965	COG2814	Major facilitator Superfamily
DDI_RS00975	COG1349	DNA-binding transcription factor activity
DDI_RS00980	COG3959	Transketolase, thiamine diphosphate binding domain
DDI_RS00985	COG3958	Transketolase
DDI_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
DDI_RS01005	COG1129	ABC transporter
DDI_RS01010	COG1172	Belongs to the binding-protein-dependent transport system permease family
DDI_RS01015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DDI_RS01040	COG0747	negative chemotaxis
DDI_RS01050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS01055	COG0444	Belongs to the ABC transporter superfamily
DDI_RS01060	COG4608	Belongs to the ABC transporter superfamily
DDI_RS01075	COG0583	DNA-binding transcription factor activity
DDI_RS01105	COG1522	sequence-specific DNA binding
DDI_RS01110	COG1605	Chorismate mutase
DDI_RS01120	COG1418	mRNA catabolic process
DDI_RS01125	COG1414	Transcriptional regulator
DDI_RS01130	COG0840	transmembrane signaling receptor activity
DDI_RS01135	COG2169	Transcriptional regulator
DDI_RS01135	COG1917	Cupin 2, conserved barrel domain protein
DDI_RS01140	COG1917	Cupin 2, conserved barrel domain protein
DDI_RS01140	COG4977	sequence-specific DNA binding
DDI_RS01160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS01170	COG0747	negative chemotaxis
DDI_RS01175	COG3477	response to acidic pH
DDI_RS01185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDI_RS01190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDI_RS01195	COG0006	proline dipeptidase activity
DDI_RS01200	COG3079	Belongs to the UPF0149 family
DDI_RS01205	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DDI_RS01215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DDI_RS01230	COG0560	Phosphoserine phosphatase
DDI_RS01235	COG3726	membrane protein affecting hemolysin expression
DDI_RS01240	COG4106	trans-aconitate 2-methyltransferase activity
DDI_RS01245	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DDI_RS01250	COG2823	Periplasmic or secreted lipoprotein
DDI_RS01260	COG0084	hydrolase, TatD family'
DDI_RS01270	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DDI_RS01275	COG0840	transmembrane signaling receptor activity
DDI_RS01280	COG1473	amidohydrolase
DDI_RS01290	COG1120	ATPase activity
DDI_RS01300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDI_RS01310	COG3634	alkyl hydroperoxide reductase activity
DDI_RS01325	COG2351	hydroxyisourate hydrolase activity
DDI_RS01380	COG0395	ABC-type sugar transport system, permease component
DDI_RS01385	COG1175	transmembrane transport
DDI_RS01390	COG1653	transport
DDI_RS01395	COG0456	acetyltransferase
DDI_RS01410	COG2971	BadF BadG BcrA BcrD
DDI_RS01430	COG1609	Transcriptional regulator
DDI_RS01460	COG3206	protein involved in exopolysaccharide biosynthesis
DDI_RS01460	COG0489	protein tyrosine kinase activity
DDI_RS01480	COG0297	glycogen (starch) synthase activity
DDI_RS01485	COG0438	transferase activity, transferring glycosyl groups
DDI_RS01485	COG0297	glycogen (starch) synthase activity
DDI_RS01500	COG1045	serine acetyltransferase
DDI_RS01525	COG1309	transcriptional regulator
DDI_RS01530	COG4232	protein-disulfide reductase activity
DDI_RS01535	COG1324	tolerance protein
DDI_RS01540	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DDI_RS01555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DDI_RS01560	COG0459	protein refolding
DDI_RS01565	COG3161	chorismate lyase activity
DDI_RS01570	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DDI_RS01575	COG2937	Belongs to the GPAT DAPAT family
DDI_RS01580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DDI_RS01585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DDI_RS01590	COG0735	belongs to the Fur family
DDI_RS01595	COG1741	Belongs to the pirin family
DDI_RS01600	COG0583	DNA-binding transcription factor activity
DDI_RS01605	COG0435	Glutathione S-transferase
DDI_RS01610	COG2259	Doxx family
DDI_RS01620	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
DDI_RS01625	COG4575	ribosome binding
DDI_RS01635	COG0586	Pfam SNARE associated Golgi protein
DDI_RS01645	COG2271	Major facilitator Superfamily
DDI_RS01660	COG1904	glucuronate isomerase
DDI_RS01670	COG0246	Mannitol dehydrogenase
DDI_RS01675	COG2721	sulfolactate sulfo-lyase activity
DDI_RS01685	COG0861	Integral membrane protein TerC family
DDI_RS01690	COG2813	Specifically methylates the guanine in position
DDI_RS01705	COG2197	response regulator
DDI_RS01715	COG2271	Major facilitator Superfamily
DDI_RS01725	COG3678	ATP-independent chaperone mediated protein folding
DDI_RS01730	COG1477	protein flavinylation
DDI_RS01750	COG1309	transcriptional regulator
DDI_RS01825	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DDI_RS01835	COG0270	DNA (cytosine-5-)-methyltransferase activity
DDI_RS01865	COG4695	Portal protein
DDI_RS02015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DDI_RS02020	COG0358	DNA primase activity
DDI_RS02025	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DDI_RS02030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DDI_RS02035	COG1438	arginine binding
DDI_RS02045	COG3423	Transcriptional regulator
DDI_RS02060	COG0142	geranyltranstransferase activity
DDI_RS02065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DDI_RS02075	COG0697	spore germination
DDI_RS02080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DDI_RS02085	COG2027	D-alanyl-D-alanine carboxypeptidase
DDI_RS02095	COG1534	Rna-binding protein
DDI_RS02100	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DDI_RS02105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DDI_RS02110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DDI_RS02115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DDI_RS02120	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DDI_RS02135	COG0779	Required for maturation of 30S ribosomal subunits
DDI_RS02140	COG0195	Participates in both transcription termination and antitermination
DDI_RS02145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DDI_RS02150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DDI_RS02155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DDI_RS02160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DDI_RS02165	COG1185	polyribonucleotide nucleotidyltransferase activity
DDI_RS02175	COG0513	Belongs to the DEAD box helicase family
DDI_RS02180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDI_RS02185	COG0826	peptidase U32
DDI_RS02190	COG0826	peptidase U32
DDI_RS02195	COG3154	lipid carrier protein
DDI_RS02200	COG3153	acetyltransferase
DDI_RS02205	COG2827	Endonuclease containing a URI domain
DDI_RS02210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DDI_RS02215	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DDI_RS02220	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DDI_RS02225	COG0813	purine-nucleoside phosphorylase activity
DDI_RS02240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DDI_RS02245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DDI_RS02280	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
DDI_RS02290	COG0667	Aldo Keto reductase
DDI_RS02295	COG0583	DNA-binding transcription factor activity
DDI_RS02335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DDI_RS02340	COG0509	glycine decarboxylation via glycine cleavage system
DDI_RS02345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DDI_RS02345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DDI_RS02355	COG1272	protein, Hemolysin III
DDI_RS02360	COG0354	folic acid binding
DDI_RS02365	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DDI_RS02375	COG0716	FMN binding
DDI_RS02380	COG0477	Major facilitator Superfamily
DDI_RS02385	COG4974	Belongs to the 'phage' integrase family
DDI_RS02390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DDI_RS02395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DDI_RS02490	COG1733	regulation of RNA biosynthetic process
DDI_RS02500	COG0745	RESPONSE REGULATOR receiver
DDI_RS02540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DDI_RS02555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DDI_RS02560	COG0395	ABC-type sugar transport system, permease component
DDI_RS02565	COG1175	transmembrane transport
DDI_RS02575	COG1560	Kdo2-lipid A biosynthetic process
DDI_RS02580	COG2252	PERMEase
DDI_RS02585	COG0025	NhaP-type Na H and K H
DDI_RS02590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DDI_RS02595	COG3162	membrane
DDI_RS02600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DDI_RS02620	COG4948	Mandelate Racemase Muconate Lactonizing
DDI_RS02625	COG0747	negative chemotaxis
DDI_RS02630	COG0601	transmembrane transport
DDI_RS02635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS02640	COG0444	Belongs to the ABC transporter superfamily
DDI_RS02645	COG4608	Belongs to the ABC transporter superfamily
DDI_RS02655	COG2211	Major facilitator Superfamily
DDI_RS02665	COG0246	Mannitol dehydrogenase
DDI_RS02670	COG2814	Major facilitator Superfamily
DDI_RS02680	COG1846	Transcriptional regulator
DDI_RS02695	COG1376	ErfK ybiS ycfS ynhG family protein
DDI_RS02700	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DDI_RS02700	COG1013	pyruvate-flavodoxin oxidoreductase activity
DDI_RS02700	COG0674	pyruvate-flavodoxin oxidoreductase activity
DDI_RS02700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDI_RS02725	COG2211	Major facilitator Superfamily
DDI_RS02750	COG1181	Belongs to the D-alanine--D-alanine ligase family
DDI_RS02765	COG3962	Belongs to the TPP enzyme family
DDI_RS02770	COG0673	inositol 2-dehydrogenase activity
DDI_RS02785	COG1172	Belongs to the binding-protein-dependent transport system permease family
DDI_RS02790	COG0673	inositol 2-dehydrogenase activity
DDI_RS02795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDI_RS02805	COG3718	enzyme involved in inositol metabolism
DDI_RS02815	COG2951	lytic endotransglycosylase activity
DDI_RS02830	COG0534	Mate efflux family protein
DDI_RS02900	COG0582	viral genome integration into host DNA
DDI_RS02915	COG2867	negative regulation of translational initiation
DDI_RS02920	COG2914	Belongs to the UPF0125 (RnfH) family
DDI_RS02930	COG0497	DNA recombination
DDI_RS02935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DDI_RS02945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DDI_RS02950	COG1914	H( )-stimulated, divalent metal cation uptake system
DDI_RS02955	COG0494	nUDIX hydrolase
DDI_RS02965	COG1671	Belongs to the UPF0178 family
DDI_RS02970	COG0408	coproporphyrinogen oxidase activity
DDI_RS02975	COG0456	acetyltransferase
DDI_RS02990	COG3423	Transcriptional regulator
DDI_RS03005	COG2837	iron assimilation
DDI_RS03015	COG0577	efflux transmembrane transporter activity
DDI_RS03015	COG1136	(ABC) transporter
DDI_RS03020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DDI_RS03025	COG0745	RESPONSE REGULATOR receiver
DDI_RS03030	COG2205	protein histidine kinase activity
DDI_RS03040	COG1733	regulation of RNA biosynthetic process
DDI_RS03045	COG2190	(PTS) system
DDI_RS03055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DDI_RS03070	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
DDI_RS03075	COG3115	cell septum assembly
DDI_RS03080	COG0531	amino acid
DDI_RS03090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DDI_RS03100	COG0446	pyridine nucleotide-disulphide oxidoreductase
DDI_RS03105	COG0426	domain, Protein
DDI_RS03105	COG1773	rubredoxin
DDI_RS03110	COG3604	Transcriptional regulator
DDI_RS03115	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DDI_RS03115	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DDI_RS03135	COG3145	DNA-N1-methyladenine dioxygenase activity
DDI_RS03140	COG1053	succinate dehydrogenase
DDI_RS03145	COG3976	FMN-binding domain protein
DDI_RS03145	COG0431	NADPH-dependent FMN reductase
DDI_RS03145	COG1053	succinate dehydrogenase
DDI_RS03150	COG0477	Major facilitator Superfamily
DDI_RS03155	COG3301	Polysulphide reductase, NrfD
DDI_RS03160	COG0437	4 iron, 4 sulfur cluster binding
DDI_RS03180	COG1609	Transcriptional regulator
DDI_RS03185	COG1234	tRNA 3'-trailer cleavage
DDI_RS03200	COG1175	transmembrane transport
DDI_RS03205	COG1653	transport
DDI_RS03215	COG0473	3-isopropylmalate dehydrogenase activity
DDI_RS03220	COG0583	DNA-binding transcription factor activity
DDI_RS03225	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DDI_RS03225	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DDI_RS03245	COG2862	Uncharacterized protein family, UPF0114
DDI_RS03270	COG0745	RESPONSE REGULATOR receiver
DDI_RS03275	COG5002	protein histidine kinase activity
DDI_RS03285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DDI_RS03295	COG1733	regulation of RNA biosynthetic process
DDI_RS03330	COG4305	rare lipoprotein A
DDI_RS03335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DDI_RS03360	COG1902	pentaerythritol trinitrate reductase activity
DDI_RS03380	COG3321	synthase
DDI_RS03380	COG0604	alcohol dehydrogenase
DDI_RS03430	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DDI_RS03475	COG3423	Transcriptional regulator
DDI_RS03485	COG0582	viral genome integration into host DNA
DDI_RS03495	COG1982	Orn Lys Arg decarboxylase major
DDI_RS03505	COG0741	lytic transglycosylase activity
DDI_RS03520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DDI_RS03525	COG3171	Protein conserved in bacteria
DDI_RS03540	COG0667	Aldo Keto reductase
DDI_RS03550	COG0861	Integral membrane protein TerC family
DDI_RS03555	COG3066	DNA modification
DDI_RS03565	COG0494	nUDIX hydrolase
DDI_RS03575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DDI_RS03580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DDI_RS03585	COG2165	general secretion pathway protein
DDI_RS03590	COG4795	General secretion pathway protein
DDI_RS03605	COG1025	Belongs to the peptidase M16 family
DDI_RS03610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DDI_RS03610	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DDI_RS03615	COG0860	N-Acetylmuramoyl-L-alanine amidase
DDI_RS03630	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DDI_RS03635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DDI_RS03645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DDI_RS03650	COG2166	iron-sulfur cluster assembly
DDI_RS03655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DDI_RS03660	COG0583	DNA-binding transcription factor activity
DDI_RS03665	COG2363	Small membrane protein
DDI_RS03670	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DDI_RS03675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DDI_RS03680	COG1611	Belongs to the LOG family
DDI_RS03710	COG2171	N-acyltransferase activity
DDI_RS03715	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DDI_RS03730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DDI_RS03735	COG0528	UMP kinase activity
DDI_RS03740	COG0233	cytoplasmic translational termination
DDI_RS03745	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DDI_RS03750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DDI_RS03755	COG0575	Belongs to the CDS family
DDI_RS03760	COG0750	zinc metalloprotease
DDI_RS03765	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DDI_RS03770	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
DDI_RS03775	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DDI_RS03780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DDI_RS03785	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DDI_RS03790	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DDI_RS03795	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DDI_RS03800	COG0587	DNA-directed DNA polymerase activity
DDI_RS03805	COG0825	malonyl-CoA metabolic process
DDI_RS03810	COG0346	lactoylglutathione lyase activity
DDI_RS03815	COG0037	tRNA processing
DDI_RS03820	COG4568	rho-dependent transcription termination
DDI_RS03830	COG4681	YaeQ
DDI_RS03835	COG3015	lipoprotein NlpE involved in copper resistance
DDI_RS03840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DDI_RS03860	COG1846	Transcriptional regulator
DDI_RS03880	COG1881	PFAM PEBP family protein
DDI_RS03910	COG2192	nodulation
DDI_RS03945	COG0546	phosphoglycolate phosphatase activity
DDI_RS03960	COG2824	Alkylphosphonate utilization operon protein PhnA
DDI_RS03965	COG3706	GGDEF domain
DDI_RS04030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DDI_RS04045	COG3123	guanosine phosphorylase activity
DDI_RS04060	COG2974	May be involved in recombination
DDI_RS04065	COG1940	carbohydrate kinase activity
DDI_RS04070	COG0419	ATPase involved in DNA repair
DDI_RS04075	COG0420	3'-5' exonuclease activity
DDI_RS04085	COG5002	protein histidine kinase activity
DDI_RS04095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DDI_RS04110	COG0450	alkyl hydroperoxide reductase
DDI_RS04115	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
DDI_RS04120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DDI_RS04125	COG0343	queuine tRNA-ribosyltransferase activity
DDI_RS04130	COG1862	Preprotein translocase
DDI_RS04135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DDI_RS04140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DDI_RS04145	COG4238	major outer membrane lipoprotein
DDI_RS04150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DDI_RS04155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DDI_RS04160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DDI_RS04160	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DDI_RS04165	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DDI_RS04170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DDI_RS04175	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DDI_RS04180	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DDI_RS04185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DDI_RS04190	COG0142	geranyltranstransferase activity
DDI_RS04195	COG1722	exodeoxyribonuclease VII activity
DDI_RS04200	COG0301	tRNA thio-modification
DDI_RS04200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DDI_RS04205	COG0693	protein deglycase activity
DDI_RS04210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DDI_RS04215	COG1666	GTP binding
DDI_RS04230	COG2814	Major facilitator Superfamily
DDI_RS04235	COG0109	protoheme IX farnesyltransferase activity
DDI_RS04240	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DDI_RS04245	COG1845	cytochrome c oxidase, subunit III
DDI_RS04250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DDI_RS04255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DDI_RS04260	COG2223	nitrite transmembrane transporter activity
DDI_RS04265	COG3056	Lipoprotein
DDI_RS04270	COG0271	Belongs to the BolA IbaG family
DDI_RS04275	COG0544	peptidyl-prolyl cis-trans isomerase activity
DDI_RS04280	COG0740	serine-type endopeptidase activity
DDI_RS04285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DDI_RS04290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DDI_RS04295	COG0776	regulation of translation
DDI_RS04300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DDI_RS04305	COG1555	photosystem II stabilization
DDI_RS04310	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DDI_RS04320	COG1522	sequence-specific DNA binding
DDI_RS04325	COG1132	(ABC) transporter
DDI_RS04330	COG1132	(ABC) transporter
DDI_RS04335	COG0347	Belongs to the P(II) protein family
DDI_RS04340	COG0004	ammonium transporteR
DDI_RS04345	COG1946	Acyl-CoA thioesterase
DDI_RS04350	COG3126	Type III secretion system lipoprotein chaperone (YscW)
DDI_RS04355	COG3695	enzyme binding
DDI_RS04375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DDI_RS04380	COG0254	rRNA binding
DDI_RS04385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DDI_RS04390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DDI_RS04395	COG1309	transcriptional regulator
DDI_RS04400	COG3264	Mechanosensitive ion channel
DDI_RS04400	COG1196	nuclear chromosome segregation
DDI_RS04415	COG2832	Protein of unknown function (DUF454)
DDI_RS04420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DDI_RS04430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DDI_RS04435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DDI_RS04440	COG0326	Molecular chaperone. Has ATPase activity
DDI_RS04445	COG0563	adenylate kinase activity
DDI_RS04450	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DDI_RS04455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DDI_RS04455	COG4651	solute:proton antiporter activity
DDI_RS04460	COG0737	Belongs to the 5'-nucleotidase family
DDI_RS04475	COG0840	transmembrane signaling receptor activity
DDI_RS04485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DDI_RS04490	COG3735	TraB family
DDI_RS04495	COG2217	Heavy metal translocating P-type atpase
DDI_RS04505	COG1585	Membrane protein implicated in regulation of membrane protease activity
DDI_RS04510	COG0330	HflC and HflK could
DDI_RS04515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DDI_RS04525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DDI_RS04530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DDI_RS04540	COG0784	Response regulator, receiver
DDI_RS04540	COG2205	protein histidine kinase activity
DDI_RS04550	COG0642	Histidine kinase
DDI_RS04550	COG2198	Histidine kinase
DDI_RS04555	COG2223	nitrite transmembrane transporter activity
DDI_RS04560	COG1169	isochorismate synthase
DDI_RS04565	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DDI_RS04570	COG0596	Alpha beta hydrolase
DDI_RS04580	COG1441	menaquinone biosynthetic process
DDI_RS04615	COG3118	belongs to the thioredoxin family
DDI_RS04620	COG0300	oxidoreductase activity
DDI_RS04625	COG2755	lipolytic protein G-D-S-L family
DDI_RS04630	COG4181	ATPase activity
DDI_RS04635	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DDI_RS04645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DDI_RS04650	COG0765	amino acid transport
DDI_RS04655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDI_RS04665	COG1129	ABC transporter
DDI_RS04670	COG1879	ABC-type sugar transport system periplasmic component
DDI_RS04685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DDI_RS04690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DDI_RS04695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DDI_RS04700	COG2233	PERMEase
DDI_RS04705	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DDI_RS04710	COG1393	Belongs to the ArsC family
DDI_RS04715	COG4783	chaperone-mediated protein folding
DDI_RS04720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DDI_RS04725	COG2716	regulation of RNA biosynthetic process
DDI_RS04735	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DDI_RS04740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DDI_RS04745	COG2707	UPF0756 membrane protein
DDI_RS04750	COG1444	tRNA N-acetyltransferase activity
DDI_RS04755	COG0400	carboxylic ester hydrolase activity
DDI_RS04765	COG1876	peptidase activity
DDI_RS04770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DDI_RS04775	COG1393	Belongs to the ArsC family
DDI_RS04785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DDI_RS04790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DDI_RS04795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DDI_RS04800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DDI_RS04805	COG0321	lipoyl(octanoyl) transferase activity
DDI_RS04810	COG2921	Belongs to the UPF0250 family
DDI_RS04815	COG1686	Belongs to the peptidase S11 family
DDI_RS04820	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DDI_RS04825	COG0772	Belongs to the SEDS family
DDI_RS04830	COG0768	penicillin binding
DDI_RS04835	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DDI_RS04840	COG0799	negative regulation of ribosome biogenesis
DDI_RS04845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DDI_RS04850	COG1466	dna polymerase III delta subunit
DDI_RS04855	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DDI_RS04860	COG0495	leucyl-tRNA aminoacylation
DDI_RS04865	COG2888	peptidyl-tyrosine sulfation
DDI_RS04870	COG1126	abc transporter atp-binding protein
DDI_RS04875	COG0765	amino acid transport
DDI_RS04880	COG0765	amino acid transport
DDI_RS04890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DDI_RS04895	COG4535	Mg2 and Co2 transporter CorC
DDI_RS04900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DDI_RS04905	COG1702	phosphate starvation-inducible protein PhoH
DDI_RS04910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DDI_RS04915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDI_RS04955	COG0367	asparagine synthase
DDI_RS04960	COG1940	carbohydrate kinase activity
DDI_RS04960	COG1846	Transcriptional regulator
DDI_RS04965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DDI_RS04970	COG0363	glucosamine-6-phosphate deaminase activity
DDI_RS04975	COG2190	(PTS) system
DDI_RS04975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DDI_RS04975	COG1263	PTS System
DDI_RS04980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DDI_RS04985	COG0735	belongs to the Fur family
DDI_RS04990	COG0716	FMN binding
DDI_RS04995	COG0840	transmembrane signaling receptor activity
DDI_RS05005	COG0596	Alpha beta hydrolase
DDI_RS05010	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
DDI_RS05015	COG0033	Phosphoglucomutase
DDI_RS05025	COG0745	RESPONSE REGULATOR receiver
DDI_RS05030	COG2205	protein histidine kinase activity
DDI_RS05035	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DDI_RS05040	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DDI_RS05045	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DDI_RS05060	COG3272	Protein of unknown function (DUF1722)
DDI_RS05065	COG0415	Belongs to the DNA photolyase family
DDI_RS05070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DDI_RS05075	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DDI_RS05080	COG1984	allophanate hydrolase subunit 2
DDI_RS05085	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DDI_RS05090	COG0372	Belongs to the citrate synthase family
DDI_RS05100	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DDI_RS05105	COG1053	succinate dehydrogenase
DDI_RS05110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DDI_RS05115	COG0567	Dehydrogenase, E1 component
DDI_RS05120	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDI_RS05125	COG0045	succinate-CoA ligase (ADP-forming) activity
DDI_RS05130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DDI_RS05140	COG1271	oxidase subunit
DDI_RS05145	COG1294	oxidase, subunit
DDI_RS05150	COG4890	Cyd operon protein YbgT
DDI_RS05155	COG3790	cyd operon protein YbgE
DDI_RS05160	COG0824	Thioesterase
DDI_RS05165	COG0811	peptide transport
DDI_RS05170	COG0848	biopolymer transport protein
DDI_RS05175	COG3064	Membrane
DDI_RS05180	COG0823	Involved in the tonB-independent uptake of proteins
DDI_RS05185	COG2885	chlorophyll binding
DDI_RS05190	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DDI_RS05205	COG1811	Na channel or pump
DDI_RS05210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DDI_RS05225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DDI_RS05230	COG0588	phosphoglycerate mutase activity
DDI_RS05240	COG2017	converts alpha-aldose to the beta-anomer
DDI_RS05245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DDI_RS05250	COG1085	galactose-1-phosphate uridylyltransferase
DDI_RS05255	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DDI_RS05260	COG1119	ATPase activity
DDI_RS05265	COG2005	Transcriptional regulator
DDI_RS05265	COG3585	molybdate ion transport
DDI_RS05275	COG0725	ABC transporter, periplasmic molybdate-binding protein
DDI_RS05280	COG4149	molybdate abc transporter
DDI_RS05285	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DDI_RS05290	COG0561	phosphatase activity
DDI_RS05295	COG2706	6-phosphogluconolactonase activity
DDI_RS05325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DDI_RS05325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DDI_RS05330	COG0489	protein tyrosine kinase activity
DDI_RS05340	COG0717	Belongs to the dCTP deaminase family
DDI_RS05345	COG2982	Protein involved in outer membrane biogenesis
DDI_RS05350	COG1253	flavin adenine dinucleotide binding
DDI_RS05385	COG1088	dTDP-glucose 4,6-dehydratase activity
DDI_RS05405	COG2244	polysaccharide biosynthetic process
DDI_RS05415	COG0463	Glycosyl transferase, family 2
DDI_RS05445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DDI_RS05475	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DDI_RS05490	COG2706	6-phosphogluconolactonase activity
DDI_RS05495	COG0783	Belongs to the Dps family
DDI_RS05500	COG2267	carboxylic ester hydrolase activity
DDI_RS05520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS05525	COG0444	Belongs to the ABC transporter superfamily
DDI_RS05540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DDI_RS05545	COG2186	Transcriptional regulator
DDI_RS05550	COG3734	2-keto-3-deoxy-galactonokinase
DDI_RS05555	COG0800	Aldolase
DDI_RS05560	COG4948	Mandelate Racemase Muconate Lactonizing
DDI_RS05565	COG2271	Major facilitator Superfamily
DDI_RS05575	COG0583	DNA-binding transcription factor activity
DDI_RS05580	COG1902	pentaerythritol trinitrate reductase activity
DDI_RS05645	COG2207	Transcriptional regulator
DDI_RS05680	COG2315	Protein conserved in bacteria
DDI_RS05690	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DDI_RS05770	COG3423	Transcriptional regulator
DDI_RS05785	COG0582	viral genome integration into host DNA
DDI_RS05795	COG3250	beta-galactosidase activity
DDI_RS05800	COG1609	Transcriptional regulator
DDI_RS05810	COG0583	DNA-binding transcription factor activity
DDI_RS05820	COG1309	transcriptional regulator
DDI_RS05825	COG1301	dicarboxylic acid transport
DDI_RS05845	COG3383	formate dehydrogenase (NAD+) activity
DDI_RS05850	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DDI_RS05865	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DDI_RS05875	COG3260	NADH ubiquinone oxidoreductase 20
DDI_RS05880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDI_RS05885	COG3261	NADH dehydrogenase
DDI_RS05885	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
DDI_RS05890	COG0651	ATP synthesis coupled electron transport
DDI_RS05895	COG4237	Hydrogenase 4 membrane
DDI_RS05900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DDI_RS05905	COG0650	Formate hydrogenlyase subunit 4
DDI_RS05910	COG0651	ATP synthesis coupled electron transport
DDI_RS05915	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DDI_RS05920	COG0298	carbon dioxide binding
DDI_RS05925	COG0583	DNA-binding transcription factor activity
DDI_RS05930	COG1301	dicarboxylic acid transport
DDI_RS05940	COG0625	glutathione transferase activity
DDI_RS05945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DDI_RS05950	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DDI_RS05960	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DDI_RS05965	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DDI_RS05975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DDI_RS05980	COG1012	belongs to the aldehyde dehydrogenase family
DDI_RS05985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DDI_RS06000	COG2188	Transcriptional regulator
DDI_RS06005	COG3624	Phosphonate C-P lyase system protein PhnG
DDI_RS06010	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
DDI_RS06015	COG3626	phosphonate metabolism
DDI_RS06020	COG3627	carbon phosphorus lyase activity
DDI_RS06025	COG4107	phosphonate C-P lyase system protein PhnK
DDI_RS06030	COG4778	phosphonate C-P lyase system protein PhnL
DDI_RS06035	COG3454	Phosphonate metabolism
DDI_RS06040	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
DDI_RS06045	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DDI_RS06060	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DDI_RS06070	COG3639	organic phosphonate transmembrane transporter activity
DDI_RS06080	COG1518	maintenance of DNA repeat elements
DDI_RS06110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DDI_RS06125	COG0019	diaminopimelate decarboxylase activity
DDI_RS06130	COG2814	Major facilitator Superfamily
DDI_RS06135	COG4264	IucA IucC family
DDI_RS06145	COG4264	IucA IucC family
DDI_RS06155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DDI_RS06160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDI_RS06165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDI_RS06170	COG1120	ATPase activity
DDI_RS06175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DDI_RS06180	COG1598	PFAM Uncharacterised protein family UPF0150
DDI_RS06215	COG3383	formate dehydrogenase (NAD+) activity
DDI_RS06215	COG0243	molybdopterin cofactor binding
DDI_RS06220	COG0437	4 iron, 4 sulfur cluster binding
DDI_RS06225	COG2864	formate dehydrogenase
DDI_RS06245	COG2211	Major facilitator Superfamily
DDI_RS06255	COG3459	Glycosyltransferase 36 associated
DDI_RS06275	COG0604	alcohol dehydrogenase
DDI_RS06285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DDI_RS06295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DDI_RS06305	COG2199	diguanylate cyclase activity
DDI_RS06310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DDI_RS06330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DDI_RS06355	COG3416	Protein conserved in bacteria
DDI_RS06375	COG2011	ABC-type metal ion transport system permease component
DDI_RS06385	COG3118	belongs to the thioredoxin family
DDI_RS06400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DDI_RS06410	COG2134	cdp-diacylglycerol pyrophosphatase
DDI_RS06420	COG4166	transmembrane transport
DDI_RS06425	COG1957	nucleoside hydrolase
DDI_RS06435	COG0601	transmembrane transport
DDI_RS06455	COG0784	Response regulator, receiver
DDI_RS06455	COG0835	chemotaxis
DDI_RS06485	COG0679	Auxin Efflux Carrier
DDI_RS06495	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DDI_RS06505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DDI_RS06510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DDI_RS06515	COG1121	(ABC) transporter
DDI_RS06520	COG0803	Belongs to the bacterial solute-binding protein 9 family
DDI_RS06525	COG0702	epimerase
DDI_RS06545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DDI_RS06550	COG4221	oxidoreductase activity
DDI_RS06575	COG0534	Mate efflux family protein
DDI_RS06635	COG3829	transcription factor binding
DDI_RS06670	COG5001	Diguanylate cyclase
DDI_RS06670	COG2203	Gaf domain
DDI_RS06670	COG3706	GGDEF domain
DDI_RS06670	COG4251	negative regulation of phosphorylation
DDI_RS06675	COG0672	)-iron permease
DDI_RS06680	COG2822	iron ion transport
DDI_RS06690	COG3813	Protein conserved in bacteria
DDI_RS06695	COG0730	response to heat
DDI_RS06700	COG1556	Lactate utilization protein
DDI_RS06705	COG1139	Iron-sulfur cluster binding protein
DDI_RS06710	COG0247	lactate metabolic process
DDI_RS06720	COG1346	cytolysis
DDI_RS06735	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DDI_RS06740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DDI_RS06745	COG0747	negative chemotaxis
DDI_RS06750	COG0601	transmembrane transport
DDI_RS06755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS06760	COG0444	Belongs to the ABC transporter superfamily
DDI_RS06765	COG1124	(ABC) transporter
DDI_RS06775	COG1566	PFAM secretion protein HlyD family protein
DDI_RS06785	COG3708	Transcriptional regulator
DDI_RS06785	COG2207	Transcriptional regulator
DDI_RS06800	COG3615	Tellurite resistance protein tehB
DDI_RS06900	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
DDI_RS06910	COG3504	Conjugal transfer protein
DDI_RS06915	COG3736	Type IV secretory pathway, component VirB8
DDI_RS06965	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DDI_RS06990	COG3423	Transcriptional regulator
DDI_RS06995	COG1476	TRANSCRIPTIONal
DDI_RS07005	COG3501	Rhs element vgr protein
DDI_RS07045	COG5489	Protein of unknown function (DUF736)
DDI_RS07050	COG0582	viral genome integration into host DNA
DDI_RS07060	COG3228	Belongs to the MtfA family
DDI_RS07080	COG0401	homolog of Blt101
DDI_RS07090	COG0463	Glycosyl transferase, family 2
DDI_RS07090	COG0457	Tetratricopeptide repeat
DDI_RS07100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DDI_RS07105	COG0303	'Molybdopterin
DDI_RS07110	COG0281	malic enzyme
DDI_RS07115	COG0295	cytidine deaminase activity
DDI_RS07120	COG1346	cytolysis
DDI_RS07125	COG1380	Effector of murein hydrolase LrgA
DDI_RS07140	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DDI_RS07145	COG0156	8-amino-7-oxononanoate synthase activity
DDI_RS07150	COG2226	methyltransferase
DDI_RS07160	COG0556	nucleotide-excision repair
DDI_RS07165	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DDI_RS07170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DDI_RS07175	COG0521	Mo-molybdopterin cofactor biosynthetic process
DDI_RS07185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DDI_RS07210	COG0670	Belongs to the BI1 family
DDI_RS07215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DDI_RS07220	COG3568	Endonuclease Exonuclease Phosphatase
DDI_RS07225	COG0842	Transport permease protein
DDI_RS07230	COG0842	Transport permease protein
DDI_RS07235	COG1131	(ABC) transporter
DDI_RS07240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DDI_RS07245	COG0513	Belongs to the DEAD box helicase family
DDI_RS07250	COG0697	spore germination
DDI_RS07270	COG2195	Cleaves the N-terminal amino acid of tripeptides
DDI_RS07275	COG0747	negative chemotaxis
DDI_RS07280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DDI_RS07290	COG1686	Belongs to the peptidase S11 family
DDI_RS07305	COG1349	DNA-binding transcription factor activity
DDI_RS07310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DDI_RS07315	COG1472	Belongs to the glycosyl hydrolase 3 family
DDI_RS07330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DDI_RS07340	COG0671	phosphoesterase, PA-phosphatase related
DDI_RS07360	COG1126	abc transporter atp-binding protein
DDI_RS07365	COG0765	amino acid transport
DDI_RS07370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDI_RS07375	COG0783	Belongs to the Dps family
DDI_RS07385	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DDI_RS07390	COG1846	Transcriptional regulator
DDI_RS07395	COG2807	transmembrane transport
DDI_RS07425	COG1984	allophanate hydrolase subunit 2
DDI_RS07445	COG1136	(ABC) transporter
DDI_RS07450	COG0577	efflux transmembrane transporter activity
DDI_RS07450	COG1136	(ABC) transporter
DDI_RS07460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DDI_RS07465	COG4677	pectinesterase activity
DDI_RS07470	COG3136	membrane protein required for alginate biosynthesis
DDI_RS07485	COG0601	transmembrane transport
DDI_RS07490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS07495	COG0444	Belongs to the ABC transporter superfamily
DDI_RS07500	COG4608	Belongs to the ABC transporter superfamily
DDI_RS07525	COG1028	Short-chain dehydrogenase reductase Sdr
DDI_RS07635	COG3082	Protein of unknown function (DUF1414)
DDI_RS07640	COG3081	Nucleoid-associated protein
DDI_RS07645	COG3275	phosphorelay sensor kinase activity
DDI_RS07650	COG3279	Response regulator of the LytR AlgR family
DDI_RS07655	COG2223	nitrite transmembrane transporter activity
DDI_RS07660	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DDI_RS07665	COG1061	Type III restriction enzyme res subunit
DDI_RS07680	COG2814	Major facilitator Superfamily
DDI_RS07695	COG4172	Belongs to the ABC transporter superfamily
DDI_RS07700	COG4239	(ABC) transporter, permease
DDI_RS07705	COG4174	ABC transporter (Permease)
DDI_RS07710	COG4166	transmembrane transport
DDI_RS07715	COG0791	NLP P60 protein
DDI_RS07720	COG0523	cobalamin synthesis protein
DDI_RS07725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DDI_RS07740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DDI_RS07740	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DDI_RS07745	COG1105	Belongs to the carbohydrate kinase PfkB family
DDI_RS07750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DDI_RS07750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DDI_RS07750	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DDI_RS07755	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DDI_RS07760	COG2855	membrane
DDI_RS07765	COG0583	DNA-binding transcription factor activity
DDI_RS07770	COG0833	amino acid
DDI_RS07780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DDI_RS07795	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDI_RS07805	COG1172	Belongs to the binding-protein-dependent transport system permease family
DDI_RS07810	COG1129	ABC transporter
DDI_RS07820	COG0371	Dehydrogenase
DDI_RS07840	COG0583	DNA-binding transcription factor activity
DDI_RS07850	COG0840	transmembrane signaling receptor activity
DDI_RS07860	COG0840	transmembrane signaling receptor activity
DDI_RS07865	COG0840	transmembrane signaling receptor activity
DDI_RS07870	COG0840	transmembrane signaling receptor activity
DDI_RS07875	COG0302	gtp cyclohydrolase
DDI_RS07880	COG2311	Membrane
DDI_RS07885	COG2949	membrane
DDI_RS07890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DDI_RS07895	COG2133	pyrroloquinoline quinone binding
DDI_RS07900	COG0625	glutathione transferase activity
DDI_RS07905	COG1464	Belongs to the NlpA lipoprotein family
DDI_RS07910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DDI_RS07915	COG2011	ABC-type metal ion transport system permease component
DDI_RS07920	COG2267	carboxylic ester hydrolase activity
DDI_RS07925	COG1686	Belongs to the peptidase S11 family
DDI_RS07930	COG1349	DNA-binding transcription factor activity
DDI_RS07935	COG0569	domain protein
DDI_RS07935	COG2985	domain, Protein
DDI_RS07960	COG0189	ligase activity
DDI_RS07970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DDI_RS07975	COG3842	ATPase activity
DDI_RS07980	COG1176	ABC-type spermidine putrescine transport system, permease component I
DDI_RS07985	COG1177	transmembrane transport
DDI_RS07995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DDI_RS08005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDI_RS08010	COG4160	amino acid transport
DDI_RS08015	COG4215	(ABC) transporter
DDI_RS08020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDI_RS08025	COG1126	abc transporter atp-binding protein
DDI_RS08030	COG3023	N-Acetylmuramoyl-L-alanine amidase
DDI_RS08035	COG0702	epimerase
DDI_RS08040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DDI_RS08045	COG1151	hydroxylamine reductase activity
DDI_RS08050	COG3593	DNA synthesis involved in DNA repair
DDI_RS08055	COG1278	Cold shock
DDI_RS08060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DDI_RS08065	COG0542	response to heat
DDI_RS08070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DDI_RS08080	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DDI_RS08085	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DDI_RS08090	COG4988	ABC transporter
DDI_RS08095	COG0492	ferredoxin-NADP+ reductase activity
DDI_RS08105	COG1674	ftsk spoiiie
DDI_RS08105	COG3107	peptidoglycan biosynthetic process
DDI_RS08110	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DDI_RS08115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DDI_RS08120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DDI_RS08125	COG3381	protein complex oligomerization
DDI_RS08140	COG0583	DNA-binding transcription factor activity
DDI_RS08145	COG2814	Major facilitator Superfamily
DDI_RS08155	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DDI_RS08160	COG1882	Formate acetyltransferase
DDI_RS08165	COG2116	formate transmembrane transporter activity
DDI_RS08170	COG1944	ATP diphosphatase activity
DDI_RS08175	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DDI_RS08180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DDI_RS08185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DDI_RS08190	COG0539	negative regulation of cytoplasmic translation
DDI_RS08195	COG0776	regulation of translation
DDI_RS08210	COG0140	phosphoribosyl-ATP diphosphatase activity
DDI_RS08210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DDI_RS08220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DDI_RS08225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DDI_RS08230	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DDI_RS08230	COG0131	Imidazoleglycerol-phosphate dehydratase
DDI_RS08235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DDI_RS08240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DDI_RS08245	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DDI_RS08250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DDI_RS08255	COG0840	transmembrane signaling receptor activity
DDI_RS08270	COG3493	citrate carrier protein
DDI_RS08275	COG0179	Fumarylacetoacetate (FAA) hydrolase
DDI_RS08280	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
DDI_RS08285	COG3052	prosthetic group binding
DDI_RS08305	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DDI_RS08310	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DDI_RS08320	COG0531	amino acid
DDI_RS08325	COG2925	Exonuclease
DDI_RS08330	COG2926	Belongs to the UPF0265 family
DDI_RS08340	COG0658	competence protein
DDI_RS08340	COG2333	competence protein COMEC
DDI_RS08345	COG1132	(ABC) transporter
DDI_RS08350	COG1663	tetraacyldisaccharide 4'-kinase activity
DDI_RS08355	COG2835	tetraacyldisaccharide 4'-kinase activity
DDI_RS08360	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DDI_RS08375	COG3173	Aminoglycoside phosphotransferase
DDI_RS08380	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DDI_RS08385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DDI_RS08390	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
DDI_RS08395	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
DDI_RS08400	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DDI_RS08415	COG2132	Multicopper oxidase
DDI_RS08420	COG1733	regulation of RNA biosynthetic process
DDI_RS08430	COG0494	nUDIX hydrolase
DDI_RS08445	COG1349	DNA-binding transcription factor activity
DDI_RS08480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DDI_RS08485	COG3381	protein complex oligomerization
DDI_RS08495	COG2999	glutathione oxidoreductase activity
DDI_RS08500	COG0477	Major facilitator Superfamily
DDI_RS08505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DDI_RS08510	COG3132	Protein of unknown function, DUF480
DDI_RS08520	COG0728	peptidoglycan biosynthetic process
DDI_RS08620	COG0018	arginyl-trna synthetase
DDI_RS08625	COG3102	Protein conserved in bacteria
DDI_RS08630	COG3142	Participates in the control of copper homeostasis
DDI_RS08640	COG0500	methyltransferase
DDI_RS08645	COG2226	methyltransferase
DDI_RS08650	COG3788	relative of glutathione S-transferase, MAPEG superfamily
DDI_RS08655	COG1801	Protein of unknown function DUF72
DDI_RS08665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DDI_RS08670	COG0494	nUDIX hydrolase
DDI_RS08685	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DDI_RS08690	COG0632	four-way junction helicase activity
DDI_RS08695	COG2255	four-way junction helicase activity
DDI_RS08700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DDI_RS08705	COG1121	(ABC) transporter
DDI_RS08710	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
DDI_RS08715	COG0739	heme binding
DDI_RS08720	COG1560	Kdo2-lipid A biosynthetic process
DDI_RS08735	COG0469	pyruvate kinase activity
DDI_RS08740	COG1737	Transcriptional regulator
DDI_RS08745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DDI_RS08750	COG0800	Aldolase
DDI_RS08755	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DDI_RS08760	COG1770	oligopeptidase
DDI_RS08775	COG1276	copper resistance
DDI_RS08780	COG1528	Iron-storage protein
DDI_RS08795	COG2204	response regulator
DDI_RS08885	COG2261	transglycosylase associated protein
DDI_RS08890	COG2718	Belongs to the UPF0229 family
DDI_RS08895	COG2766	serine protein kinase
DDI_RS08900	COG3713	MltA-interacting MipA family protein
DDI_RS08905	COG0656	L-ascorbic acid biosynthetic process
DDI_RS08920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DDI_RS08925	COG3139	Protein of unknown function (DUF1315)
DDI_RS08930	COG1335	isochorismatase
DDI_RS08935	COG0252	asparaginase activity
DDI_RS08940	COG0616	signal peptide processing
DDI_RS08945	COG0778	Nitroreductase
DDI_RS08950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DDI_RS08965	COG2860	membrane
DDI_RS08975	COG0788	formyltetrahydrofolate deformylase activity
DDI_RS08980	COG3012	SEC-C Motif Domain Protein
DDI_RS08985	COG1752	Esterase of the alpha-beta hydrolase superfamily
DDI_RS08990	COG0745	RESPONSE REGULATOR receiver
DDI_RS08995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DDI_RS09005	COG1435	thymidine kinase activity
DDI_RS09010	COG1012	belongs to the aldehyde dehydrogenase family
DDI_RS09010	COG1454	alcohol dehydrogenase
DDI_RS09015	COG2095	MarC family integral membrane protein
DDI_RS09030	COG0601	transmembrane transport
DDI_RS09035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS09040	COG0444	Belongs to the ABC transporter superfamily
DDI_RS09050	COG3099	Belongs to the UPF0263 family
DDI_RS09055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DDI_RS09070	COG2350	Protein conserved in bacteria
DDI_RS09085	COG2917	probably involved in intracellular septation
DDI_RS09100	COG3047	cAMP biosynthetic process
DDI_RS09105	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DDI_RS09110	COG0159	tryptophan synthase activity
DDI_RS09115	COG0133	tryptophan synthase activity
DDI_RS09120	COG0135	phosphoribosylanthranilate isomerase activity
DDI_RS09120	COG0134	indole-3-glycerol-phosphate synthase activity
DDI_RS09125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DDI_RS09130	COG0512	Glutamine amidotransferase of anthranilate synthase
DDI_RS09140	COG0613	PHP domain protein
DDI_RS09145	COG0009	L-threonylcarbamoyladenylate synthase
DDI_RS09150	COG1187	pseudouridine synthase activity
DDI_RS09155	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DDI_RS09160	COG1028	Short-chain dehydrogenase reductase Sdr
DDI_RS09165	COG0616	signal peptide processing
DDI_RS09190	COG0583	DNA-binding transcription factor activity
DDI_RS09195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DDI_RS09205	COG4659	FMN binding
DDI_RS09210	COG4658	electron transport chain
DDI_RS09215	COG4656	Part of a membrane complex involved in electron transport
DDI_RS09220	COG2878	Part of a membrane complex involved in electron transport
DDI_RS09225	COG4657	Part of a membrane complex involved in electron transport
DDI_RS09235	COG2160	L-arabinose isomerase activity
DDI_RS09240	COG1069	ribulokinase activity
DDI_RS09245	COG1879	ABC-type sugar transport system periplasmic component
DDI_RS09250	COG1129	ABC transporter
DDI_RS09255	COG1172	Belongs to the binding-protein-dependent transport system permease family
DDI_RS09265	COG0673	inositol 2-dehydrogenase activity
DDI_RS09270	COG0385	Bile acid
DDI_RS09280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DDI_RS09285	COG5339	Protein conserved in bacteria
DDI_RS09290	COG1482	cell wall glycoprotein biosynthetic process
DDI_RS09295	COG0114	fumarate hydratase activity
DDI_RS09305	COG2814	Major facilitator Superfamily
DDI_RS09310	COG0583	DNA-binding transcription factor activity
DDI_RS09315	COG1940	carbohydrate kinase activity
DDI_RS09320	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DDI_RS09330	COG4221	oxidoreductase activity
DDI_RS09335	COG1215	transferase activity, transferring glycosyl groups
DDI_RS09345	COG5642	Protein of unknown function (DUF2384)
DDI_RS09350	COG5654	RES domain protein
DDI_RS09375	COG4305	rare lipoprotein A
DDI_RS09390	COG3158	transport of potassium into the cell
DDI_RS09430	COG0702	epimerase
DDI_RS09460	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DDI_RS09465	COG0483	inositol monophosphate 1-phosphatase activity
DDI_RS09470	COG0584	glycerophosphoryl diester phosphodiesterase
DDI_RS09490	COG3842	ATPase activity
DDI_RS09505	COG3479	Phenolic acid decarboxylase
DDI_RS09540	COG0840	transmembrane signaling receptor activity
DDI_RS09560	COG0840	transmembrane signaling receptor activity
DDI_RS09570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DDI_RS09580	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DDI_RS09585	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DDI_RS09595	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DDI_RS09605	COG2890	protein-(glutamine-N5) methyltransferase activity
DDI_RS09610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DDI_RS09615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DDI_RS09620	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DDI_RS09625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DDI_RS09630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DDI_RS09640	COG0193	aminoacyl-tRNA hydrolase activity
DDI_RS09645	COG0012	GTP binding
DDI_RS09650	COG2211	Major facilitator Superfamily
DDI_RS09660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDI_RS09675	COG1609	Transcriptional regulator
DDI_RS09680	COG0513	Belongs to the DEAD box helicase family
DDI_RS09685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DDI_RS09690	COG1074	ATP-dependent DNA helicase activity
DDI_RS09695	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DDI_RS09750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DDI_RS09755	COG2719	SpoVR family
DDI_RS09760	COG2186	Transcriptional regulator
DDI_RS09765	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DDI_RS09770	COG2983	Belongs to the UPF0260 family
DDI_RS09775	COG0179	Fumarylacetoacetate (FAA) hydrolase
DDI_RS09785	COG0850	regulation of cytokinetic process
DDI_RS09790	COG2894	cell division
DDI_RS09795	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DDI_RS09800	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DDI_RS09805	COG0318	PFAM AMP-dependent synthetase and ligase
DDI_RS09810	COG3065	identical protein binding
DDI_RS09820	COG1199	ATP-dependent helicase activity
DDI_RS09825	COG0251	oxidation-reduction process
DDI_RS09840	COG0494	nUDIX hydrolase
DDI_RS09845	COG1760	l-serine dehydratase
DDI_RS09850	COG0840	transmembrane signaling receptor activity
DDI_RS09855	COG1253	flavin adenine dinucleotide binding
DDI_RS09860	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DDI_RS09860	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DDI_RS09865	COG3715	PTS system
DDI_RS09870	COG3716	PTS system mannose fructose sorbose family IID component
DDI_RS09875	COG4811	Protein of unknown function (DUF986)
DDI_RS09880	COG1971	Probably functions as a manganese efflux pump
DDI_RS09885	COG2226	methyltransferase
DDI_RS09900	COG3001	Fructosamine kinase
DDI_RS09910	COG1917	Cupin 2, conserved barrel domain protein
DDI_RS09915	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DDI_RS09920	COG1028	Short-chain dehydrogenase reductase Sdr
DDI_RS09930	COG1175	transmembrane transport
DDI_RS09935	COG0395	ABC-type sugar transport system, permease component
DDI_RS09940	COG3842	ATPase activity
DDI_RS09950	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DDI_RS09955	COG2755	lipolytic protein G-D-S-L family
DDI_RS09955	COG0657	acetylesterase activity
DDI_RS09960	COG1988	membrane-bound metal-dependent
DDI_RS09965	COG1823	symporter activity
DDI_RS09970	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DDI_RS09975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DDI_RS09990	COG0776	regulation of translation
DDI_RS09995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DDI_RS09995	COG0072	phenylalanine-tRNA ligase activity
DDI_RS10000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DDI_RS10010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DDI_RS10015	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DDI_RS10020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DDI_RS10035	COG0823	Involved in the tonB-independent uptake of proteins
DDI_RS10040	COG0501	Belongs to the peptidase M48B family
DDI_RS10050	COG0538	isocitrate dehydrogenase activity
DDI_RS10065	COG0482	sulfurtransferase activity
DDI_RS10070	COG2915	High frequency lysogenization protein hflD homolog
DDI_RS10075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DDI_RS10090	COG2850	peptidyl-arginine hydroxylation
DDI_RS10095	COG2195	Cleaves the N-terminal amino acid of tripeptides
DDI_RS10105	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DDI_RS10145	COG1476	TRANSCRIPTIONal
DDI_RS10185	COG3609	addiction module antidote protein, CC2985 family
DDI_RS10190	COG4974	Belongs to the 'phage' integrase family
DDI_RS10195	COG1476	TRANSCRIPTIONal
DDI_RS10205	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DDI_RS10225	COG3210	domain, Protein
DDI_RS10230	COG2831	hemolysin activation secretion protein
DDI_RS10285	COG2951	lytic endotransglycosylase activity
DDI_RS10320	COG2197	response regulator
DDI_RS10325	COG4585	Histidine kinase
DDI_RS10375	COG4794	Type iii secretion
DDI_RS10385	COG4792	protein secretion
DDI_RS10390	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
DDI_RS10395	COG0840	transmembrane signaling receptor activity
DDI_RS10400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DDI_RS10410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DDI_RS10415	COG1473	amidohydrolase
DDI_RS10420	COG1028	Short-chain dehydrogenase reductase Sdr
DDI_RS10425	COG4172	Belongs to the ABC transporter superfamily
DDI_RS10430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS10445	COG2223	nitrite transmembrane transporter activity
DDI_RS10450	COG0483	inositol monophosphate 1-phosphatase activity
DDI_RS10455	COG1349	DNA-binding transcription factor activity
DDI_RS10465	COG1176	ABC-type spermidine putrescine transport system, permease component I
DDI_RS10475	COG1012	belongs to the aldehyde dehydrogenase family
DDI_RS10480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DDI_RS10490	COG3842	ATPase activity
DDI_RS10545	COG1454	alcohol dehydrogenase
DDI_RS10550	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DDI_RS10555	COG2181	nitrate reductase activity
DDI_RS10560	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DDI_RS10565	COG1140	nitrate reductase beta subunit
DDI_RS10570	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DDI_RS10575	COG0583	DNA-binding transcription factor activity
DDI_RS10585	COG2223	nitrite transmembrane transporter activity
DDI_RS10590	COG3850	Histidine kinase
DDI_RS10595	COG2197	response regulator
DDI_RS10610	COG0793	Belongs to the peptidase S41A family
DDI_RS10615	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
DDI_RS10620	COG1956	GAF domain-containing protein
DDI_RS10625	COG2995	paraquat-inducible protein a
DDI_RS10630	COG3008	intermembrane lipid transfer
DDI_RS10635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DDI_RS10635	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DDI_RS10670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DDI_RS10720	COG2840	Smr protein MutS2
DDI_RS10740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DDI_RS10795	COG0402	S-adenosylhomocysteine deaminase activity
DDI_RS10805	COG0840	transmembrane signaling receptor activity
DDI_RS10815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DDI_RS10825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DDI_RS10830	COG0444	Belongs to the ABC transporter superfamily
DDI_RS10835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS10840	COG0601	transmembrane transport
DDI_RS10845	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DDI_RS10850	COG0387	Pfam Sodium calcium exchanger
DDI_RS10855	COG0659	secondary active sulfate transmembrane transporter activity
DDI_RS10865	COG0745	RESPONSE REGULATOR receiver
DDI_RS10870	COG2205	protein histidine kinase activity
DDI_RS10880	COG3591	Belongs to the peptidase S1B family
DDI_RS10885	COG1620	l-lactate permease
DDI_RS10890	COG0247	lactate metabolic process
DDI_RS10895	COG1139	Iron-sulfur cluster binding protein
DDI_RS10900	COG1556	Lactate utilization protein
DDI_RS10905	COG1643	Atp-dependent helicase
DDI_RS10910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DDI_RS10920	COG2911	Protein conserved in bacteria
DDI_RS10925	COG0840	transmembrane signaling receptor activity
DDI_RS10955	COG0037	tRNA processing
DDI_RS10965	COG0598	Magnesium transport protein CorA
DDI_RS10970	COG4166	transmembrane transport
DDI_RS10975	COG2866	Carboxypeptidase
DDI_RS10980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DDI_RS10985	COG0477	Major facilitator Superfamily
DDI_RS11000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DDI_RS11025	COG2271	Major facilitator Superfamily
DDI_RS11030	COG3768	UPF0283 membrane protein
DDI_RS11035	COG3106	COG3106 Predicted ATPase
DDI_RS11040	COG1983	PspC domain protein
DDI_RS11050	COG1842	Phage shock protein A
DDI_RS11055	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DDI_RS11075	COG4172	Belongs to the ABC transporter superfamily
DDI_RS11100	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
DDI_RS11105	COG4989	oxidoreductase activity
DDI_RS11110	COG1966	Carbon starvation protein
DDI_RS11130	COG0023	Translation Initiation Factor
DDI_RS11140	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DDI_RS11145	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
DDI_RS11150	COG0671	phosphoesterase, PA-phosphatase related
DDI_RS11165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DDI_RS11170	COG0625	glutathione transferase activity
DDI_RS11175	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DDI_RS11190	COG3895	Periplasmic Protein
DDI_RS11195	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DDI_RS11210	COG3313	Fe-S protein
DDI_RS11215	COG0346	lactoylglutathione lyase activity
DDI_RS11220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DDI_RS11225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DDI_RS11230	COG0791	NLP P60 protein
DDI_RS11240	COG1609	Transcriptional regulator
DDI_RS11245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DDI_RS11250	COG0307	riboflavin synthase, alpha
DDI_RS11255	COG0534	Mate efflux family protein
DDI_RS11270	COG0667	Aldo Keto reductase
DDI_RS11305	COG1403	HNH endonuclease
DDI_RS11335	COG2207	Transcriptional regulator
DDI_RS11340	COG0583	DNA-binding transcription factor activity
DDI_RS11345	COG2382	esterase
DDI_RS11375	COG4238	major outer membrane lipoprotein
DDI_RS11380	COG1376	ErfK ybiS ycfS ynhG family protein
DDI_RS11380	COG1388	LysM domain
DDI_RS11385	COG2166	iron-sulfur cluster assembly
DDI_RS11390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DDI_RS11395	COG0719	Fe-S assembly protein
DDI_RS11400	COG0396	ATPase activity
DDI_RS11405	COG0719	Fe-S assembly protein
DDI_RS11410	COG0316	Belongs to the HesB IscA family
DDI_RS11420	COG2050	protein possibly involved in aromatic compounds catabolism
DDI_RS11425	COG0247	lactate metabolic process
DDI_RS11425	COG0277	FAD linked oxidase domain protein
DDI_RS11430	COG0628	permease
DDI_RS11440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DDI_RS11440	COG0574	Belongs to the PEP-utilizing enzyme family
DDI_RS11445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DDI_RS11450	COG3130	regulation of translation
DDI_RS11455	COG3009	Protein conserved in bacteria
DDI_RS11460	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DDI_RS11460	COG3008	intermembrane lipid transfer
DDI_RS11465	COG2995	paraquat-inducible protein a
DDI_RS11470	COG0488	(ABC) transporter
DDI_RS11475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DDI_RS11475	COG0116	Belongs to the methyltransferase superfamily
DDI_RS11480	COG3217	Mosc domain protein beta barrel domain protein
DDI_RS11480	COG0633	Ferredoxin
DDI_RS11490	COG0167	dihydroorotate dehydrogenase activity
DDI_RS11495	COG0431	NADPH-dependent FMN reductase
DDI_RS11500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DDI_RS11505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDI_RS11510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DDI_RS11515	COG1116	anion transmembrane transporter activity
DDI_RS11520	COG0308	aminopeptidase N
DDI_RS11525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DDI_RS11530	COG0017	Asparaginyl-tRNA synthetase
DDI_RS11550	COG1448	Aminotransferase
DDI_RS11555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DDI_RS11560	COG3108	Peptidase M15
DDI_RS11565	COG2989	Protein conserved in bacteria
DDI_RS11570	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DDI_RS11585	COG0791	NLP P60 protein
DDI_RS11590	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
DDI_RS11595	COG0386	Belongs to the glutathione peroxidase family
DDI_RS11600	COG4139	cobalamin transport
DDI_RS11615	COG4591	ABC-type transport system involved in lipoprotein release permease component
DDI_RS11620	COG1136	(ABC) transporter
DDI_RS11625	COG4591	ABC-type transport system involved in lipoprotein release permease component
DDI_RS11630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DDI_RS11635	COG2200	EAL domain
DDI_RS11640	COG0443	Heat shock 70 kDa protein
DDI_RS11660	COG2271	Major facilitator Superfamily
DDI_RS11665	COG1609	Transcriptional regulator
DDI_RS11670	COG3134	Outer membrane lipoprotein
DDI_RS11675	COG1252	NADH dehydrogenase
DDI_RS11685	COG1472	Belongs to the glycosyl hydrolase 3 family
DDI_RS11695	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
DDI_RS11700	COG5633	Lipoprotein
DDI_RS11705	COG0537	adenosine 5'-monophosphoramidase activity
DDI_RS11710	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DDI_RS11715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DDI_RS11715	COG1263	PTS System
DDI_RS11720	COG0084	hydrolase, TatD family'
DDI_RS11725	COG0470	DNA polymerase III
DDI_RS11730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DDI_RS11735	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DDI_RS11740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DDI_RS11745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DDI_RS11750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDI_RS11765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DDI_RS11770	COG0416	fatty acid biosynthetic process
DDI_RS11775	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DDI_RS11780	COG1399	metal-binding, possibly nucleic acid-binding protein
DDI_RS11785	COG0424	maF-like protein
DDI_RS11790	COG0564	pseudouridine synthase activity
DDI_RS11795	COG1530	ribonuclease E activity
DDI_RS11805	COG0418	dihydroorotase activity
DDI_RS11820	COG3038	cytochrome b561
DDI_RS11830	COG1054	Belongs to the UPF0176 family
DDI_RS11835	COG1902	pentaerythritol trinitrate reductase activity
DDI_RS11840	COG1560	Kdo2-lipid A biosynthetic process
DDI_RS11845	COG2943	transferase activity, transferring hexosyl groups
DDI_RS11850	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DDI_RS11865	COG0840	transmembrane signaling receptor activity
DDI_RS11885	COG1067	ATP-dependent peptidase activity
DDI_RS11890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DDI_RS11915	COG1702	phosphate starvation-inducible protein PhoH
DDI_RS11930	COG1191	sigma factor activity
DDI_RS11945	COG0673	inositol 2-dehydrogenase activity
DDI_RS11960	COG0500	methyltransferase
DDI_RS11970	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DDI_RS11985	COG1677	Flagellar hook-basal body complex protein FliE
DDI_RS12000	COG1317	bacterial-type flagellum organization
DDI_RS12020	COG1580	Controls the rotational direction of flagella during chemotaxis
DDI_RS12055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DDI_RS12060	COG1256	bacterial-type flagellum assembly
DDI_RS12070	COG1706	bacterial-type flagellum-dependent cell motility
DDI_RS12075	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DDI_RS12085	COG4787	bacterial-type flagellum-dependent cell motility
DDI_RS12090	COG1749	Flagellar hook protein flgE
DDI_RS12095	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DDI_RS12100	COG1558	bacterial-type flagellum-dependent cell motility
DDI_RS12105	COG1815	bacterial-type flagellum-dependent cell motility
DDI_RS12115	COG2747	anti-sigma28 factor FlgM
DDI_RS12130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DDI_RS12135	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DDI_RS12140	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DDI_RS12145	COG0745	RESPONSE REGULATOR receiver
DDI_RS12150	COG2201	protein-glutamate methylesterase activity
DDI_RS12155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DDI_RS12160	COG0840	transmembrane signaling receptor activity
DDI_RS12165	COG0835	chemotaxis
DDI_RS12170	COG2198	Histidine kinase
DDI_RS12170	COG0643	Histidine kinase
DDI_RS12180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DDI_RS12200	COG0840	transmembrane signaling receptor activity
DDI_RS12210	COG0534	Mate efflux family protein
DDI_RS12220	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DDI_RS12225	COG4733	cellulase activity
DDI_RS12270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DDI_RS12280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DDI_RS12280	COG2070	2-Nitropropane dioxygenase
DDI_RS12290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDI_RS12290	COG1028	Short-chain dehydrogenase reductase Sdr
DDI_RS12290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DDI_RS12290	COG3321	synthase
DDI_RS12290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DDI_RS12290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDI_RS12290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDI_RS12290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDI_RS12290	COG1028	Short-chain dehydrogenase reductase Sdr
DDI_RS12290	COG3321	synthase
DDI_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
DDI_RS12295	COG3321	synthase
DDI_RS12295	COG0300	oxidoreductase activity
DDI_RS12295	COG0318	PFAM AMP-dependent synthetase and ligase
DDI_RS12295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDI_RS12310	COG1028	Short-chain dehydrogenase reductase Sdr
DDI_RS12310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDI_RS12310	COG0300	oxidoreductase activity
DDI_RS12310	COG3321	synthase
DDI_RS12310	COG0318	PFAM AMP-dependent synthetase and ligase
DDI_RS12315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDI_RS12315	COG3321	synthase
DDI_RS12315	COG4221	oxidoreductase activity
DDI_RS12315	COG1028	Short-chain dehydrogenase reductase Sdr
DDI_RS12320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDI_RS12325	COG4221	oxidoreductase activity
DDI_RS12325	COG3321	synthase
DDI_RS12325	COG0300	oxidoreductase activity
DDI_RS12325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDI_RS12330	COG2072	flavoprotein involved in K transport
DDI_RS12335	COG4221	oxidoreductase activity
DDI_RS12335	COG3321	synthase
DDI_RS12335	COG0300	oxidoreductase activity
DDI_RS12335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDI_RS12340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDI_RS12345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DDI_RS12350	COG3425	synthase
DDI_RS12355	COG1024	Enoyl-CoA hydratase
DDI_RS12360	COG1024	Enoyl-CoA hydratase
DDI_RS12375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DDI_RS12380	COG0322	excinuclease ABC activity
DDI_RS12385	COG2197	response regulator
DDI_RS12400	COG1113	amino acid transport
DDI_RS12430	COG1819	glycosyl
DDI_RS12440	COG0840	transmembrane signaling receptor activity
DDI_RS12450	COG0583	DNA-binding transcription factor activity
DDI_RS12455	COG0436	Aminotransferase
DDI_RS12475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DDI_RS12475	COG1648	precorrin-2 dehydrogenase activity
DDI_RS12480	COG0243	molybdopterin cofactor binding
DDI_RS12485	COG2146	nitrite reductase [NAD(P)H] activity
DDI_RS12485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DDI_RS12490	COG1116	anion transmembrane transporter activity
DDI_RS12500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DDI_RS12505	COG3707	response regulator
DDI_RS12515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DDI_RS12520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DDI_RS12530	COG2814	Major facilitator Superfamily
DDI_RS12535	COG0657	acetylesterase activity
DDI_RS12540	COG3058	Necessary for formate dehydrogenase activity
DDI_RS12545	COG2271	Major facilitator Superfamily
DDI_RS12555	COG2864	formate dehydrogenase
DDI_RS12560	COG0437	4 iron, 4 sulfur cluster binding
DDI_RS12565	COG3383	formate dehydrogenase (NAD+) activity
DDI_RS12565	COG0243	molybdopterin cofactor binding
DDI_RS12575	COG0519	Catalyzes the synthesis of GMP from XMP
DDI_RS12575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DDI_RS12585	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DDI_RS12590	COG0309	Hydrogenase expression formation protein (HypE)
DDI_RS12595	COG0409	Hydrogenase expression formation protein
DDI_RS12600	COG0298	carbon dioxide binding
DDI_RS12605	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DDI_RS12615	COG1773	rubredoxin
DDI_RS12620	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DDI_RS12625	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DDI_RS12630	COG5557	Pfam Polysulphide reductase, NrfD
DDI_RS12635	COG0437	4 iron, 4 sulfur cluster binding
DDI_RS12640	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DDI_RS12645	COG0488	(ABC) transporter
DDI_RS12650	COG0384	phenazine biosynthesis protein PhzF
DDI_RS12655	COG2132	Multicopper oxidase
DDI_RS12660	COG1007	ATP synthesis coupled electron transport
DDI_RS12665	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDI_RS12670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DDI_RS12675	COG0713	ATP synthesis coupled electron transport
DDI_RS12680	COG0839	Belongs to the complex I subunit 6 family
DDI_RS12685	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDI_RS12690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DDI_RS12700	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DDI_RS12710	COG0649	NAD binding
DDI_RS12710	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDI_RS12720	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDI_RS12725	COG0583	DNA-binding transcription factor activity
DDI_RS12730	COG0436	Aminotransferase
DDI_RS12735	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DDI_RS12740	COG0471	metal ion transport
DDI_RS12740	COG0490	domain, Protein
DDI_RS12745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DDI_RS12750	COG3013	Belongs to the UPF0304 family
DDI_RS12755	COG3092	negative regulation of chromosome organization
DDI_RS12765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DDI_RS12770	COG0280	phosphate acetyltransferase
DDI_RS12770	COG0857	belongs to the CobB CobQ family
DDI_RS12775	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DDI_RS12780	COG0622	Phosphoesterase
DDI_RS12785	COG0625	glutathione transferase activity
DDI_RS12790	COG1090	epimerase
DDI_RS12805	COG4215	(ABC) transporter
DDI_RS12810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDI_RS12815	COG0163	prenyltransferase activity
DDI_RS12820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DDI_RS12825	COG1286	toxin biosynthetic process
DDI_RS12830	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
DDI_RS12835	COG0285	dihydrofolate synthase activity
DDI_RS12840	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DDI_RS12850	COG0586	Pfam SNARE associated Golgi protein
DDI_RS12860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DDI_RS12865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DDI_RS12900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DDI_RS12905	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DDI_RS12905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DDI_RS12935	COG3101	peptidyl-lysine hydroxylation
DDI_RS12940	COG0730	response to heat
DDI_RS12945	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
DDI_RS12950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DDI_RS12955	COG2890	protein-(glutamine-N5) methyltransferase activity
DDI_RS12960	COG2840	Smr protein MutS2
DDI_RS12965	COG2062	phosphohistidine phosphatase, SixA
DDI_RS12970	COG1024	Enoyl-CoA hydratase
DDI_RS12970	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDI_RS12985	COG3691	Protein conserved in bacteria
DDI_RS12990	COG2067	long-chain fatty acid transport protein
DDI_RS12995	COG0579	oxidoreductase
DDI_RS13015	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DDI_RS13025	COG4592	Periplasmic binding protein
DDI_RS13035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDI_RS13040	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDI_RS13045	COG1120	ATPase activity
DDI_RS13065	COG2382	esterase
DDI_RS13070	COG4774	siderophore transport
DDI_RS13075	COG1169	isochorismate synthase
DDI_RS13080	COG1021	2,3-dihydroxybenzoate-AMP ligase
DDI_RS13085	COG3433	isochorismatase activity
DDI_RS13085	COG1535	isochorismatase
DDI_RS13090	COG1028	Short-chain dehydrogenase reductase Sdr
DDI_RS13095	COG2050	protein possibly involved in aromatic compounds catabolism
DDI_RS13100	COG1902	pentaerythritol trinitrate reductase activity
DDI_RS13160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DDI_RS13170	COG3031	protein transport across the cell outer membrane
DDI_RS13180	COG3266	domain, Protein
DDI_RS13190	COG0436	Aminotransferase
DDI_RS13195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DDI_RS13200	COG1511	domain protein
DDI_RS13200	COG3264	Mechanosensitive ion channel
DDI_RS13220	COG2850	peptidyl-arginine hydroxylation
DDI_RS13240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DDI_RS13240	COG1263	PTS System
DDI_RS13245	COG1874	Beta-galactosidase
DDI_RS13250	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DDI_RS13255	COG3833	ABC-type maltose transport systems, permease component
DDI_RS13260	COG1175	transmembrane transport
DDI_RS13265	COG2182	Extracellular solute-binding protein
DDI_RS13290	COG5297	Belongs to the glycosyl hydrolase family 6
DDI_RS13300	COG1063	alcohol dehydrogenase
DDI_RS13305	COG0477	Major facilitator Superfamily
DDI_RS13310	COG1802	Transcriptional regulator
DDI_RS13315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DDI_RS13320	COG2986	histidine ammonia-lyase
DDI_RS13340	COG2986	histidine ammonia-lyase
DDI_RS13370	COG0402	S-adenosylhomocysteine deaminase activity
DDI_RS13380	COG2085	NADP oxidoreductase coenzyme F420-dependent
DDI_RS13385	COG1846	Transcriptional regulator
DDI_RS13390	COG0583	DNA-binding transcription factor activity
DDI_RS13395	COG4948	Mandelate Racemase Muconate Lactonizing
DDI_RS13405	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DDI_RS13445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DDI_RS13450	COG2501	S4 domain
DDI_RS13455	COG0215	cysteine-tRNA ligase activity
DDI_RS13465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DDI_RS13470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DDI_RS13475	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DDI_RS13480	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DDI_RS13485	COG0814	amino acid
DDI_RS13490	COG1760	l-serine dehydratase
DDI_RS13500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DDI_RS13505	COG0581	inorganic phosphate transmembrane transporter activity
DDI_RS13515	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DDI_RS13530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DDI_RS13535	COG0589	response to stress
DDI_RS13555	COG0670	Belongs to the BI1 family
DDI_RS13560	COG2920	part of a sulfur-relay system
DDI_RS13565	COG1254	Belongs to the acylphosphatase family
DDI_RS13570	COG3785	DNA binding
DDI_RS13575	COG1832	CoA-binding protein
DDI_RS13585	COG1803	Methylglyoxal synthase
DDI_RS13590	COG0210	DNA helicase
DDI_RS13595	COG3304	Inner membrane component domain
DDI_RS13600	COG1289	transmembrane transporter activity
DDI_RS13605	COG3070	regulator of competence-specific genes
DDI_RS13610	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
DDI_RS13615	COG2885	chlorophyll binding
DDI_RS13615	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DDI_RS13620	COG0667	Aldo Keto reductase
DDI_RS13625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DDI_RS13630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DDI_RS13635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DDI_RS13640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DDI_RS13645	COG0477	Major facilitator Superfamily
DDI_RS13650	COG2205	protein histidine kinase activity
DDI_RS13655	COG0745	RESPONSE REGULATOR receiver
DDI_RS13660	COG0435	Glutathione S-transferase
DDI_RS13665	COG0826	peptidase U32
DDI_RS13670	COG3223	Belongs to the PsiE family
DDI_RS13680	COG2211	Major facilitator Superfamily
DDI_RS13690	COG0673	inositol 2-dehydrogenase activity
DDI_RS13705	COG0351	phosphomethylpyrimidine kinase
DDI_RS13710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDI_RS13715	COG0765	amino acid transport
DDI_RS13725	COG0765	amino acid transport
DDI_RS13755	COG2165	general secretion pathway protein
DDI_RS13815	COG0300	oxidoreductase activity
DDI_RS13875	COG4584	PFAM Integrase catalytic
DDI_RS13880	COG1396	sequence-specific DNA binding
DDI_RS13885	COG5489	Protein of unknown function (DUF736)
DDI_RS13900	COG1475	DNA binding
DDI_RS13920	COG2003	Belongs to the UPF0758 family
DDI_RS13970	COG0582	viral genome integration into host DNA
DDI_RS13980	COG0516	GMP reductase activity
DDI_RS13980	COG0517	IMP dehydrogenase activity
DDI_RS13985	COG1570	exodeoxyribonuclease VII activity
DDI_RS14000	COG1160	GTP binding
DDI_RS14005	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DDI_RS14010	COG2976	Protein conserved in bacteria
DDI_RS14015	COG0124	histidyl-tRNA synthetase
DDI_RS14020	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DDI_RS14025	COG1426	Protein conserved in bacteria
DDI_RS14035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DDI_RS14040	COG0105	UTP biosynthetic process
DDI_RS14045	COG2897	thiosulfate sulfurtransferase activity
DDI_RS14055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DDI_RS14060	COG2975	iron-sulfur cluster assembly
DDI_RS14065	COG0633	Ferredoxin
DDI_RS14070	COG0443	Heat shock 70 kDa protein
DDI_RS14075	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DDI_RS14080	COG0316	Belongs to the HesB IscA family
DDI_RS14085	COG0822	iron-sulfur transferase activity
DDI_RS14095	COG1959	2 iron, 2 sulfur cluster binding
DDI_RS14100	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DDI_RS14105	COG0483	inositol monophosphate 1-phosphatase activity
DDI_RS14115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDI_RS14120	COG1120	ATPase activity
DDI_RS14130	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
DDI_RS14135	COG3683	transport system, periplasmic component
DDI_RS14140	COG2814	Major facilitator Superfamily
DDI_RS14145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DDI_RS14150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DDI_RS14150	COG1017	nitric oxide dioxygenase activity
DDI_RS14175	COG4677	pectinesterase activity
DDI_RS14180	COG0347	Belongs to the P(II) protein family
DDI_RS14185	COG2204	response regulator
DDI_RS14190	COG3170	Tfp pilus assembly protein FimV
DDI_RS14195	COG2205	protein histidine kinase activity
DDI_RS14200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DDI_RS14200	COG0047	phosphoribosylformylglycinamidine synthase activity
DDI_RS14205	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DDI_RS14215	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DDI_RS14225	COG2274	protein secretion by the type I secretion system
DDI_RS14240	COG2200	EAL domain
DDI_RS14245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DDI_RS14250	COG0736	holo-[acyl-carrier-protein] synthase activity
DDI_RS14255	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DDI_RS14260	COG1381	Involved in DNA repair and RecF pathway recombination
DDI_RS14265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DDI_RS14270	COG0571	ribonuclease III activity
DDI_RS14280	COG0481	GTPase activity
DDI_RS14285	COG3086	response to oxidative stress
DDI_RS14290	COG3026	antisigma factor binding
DDI_RS14305	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DDI_RS14310	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DDI_RS14315	COG0513	Belongs to the DEAD box helicase family
DDI_RS14320	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
DDI_RS14325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DDI_RS14340	COG2873	o-acetylhomoserine
DDI_RS14345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DDI_RS14375	COG0679	Auxin Efflux Carrier
DDI_RS14390	COG1447	Phosphotransferase system cellobiose-specific component IIA
DDI_RS14430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DDI_RS14435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DDI_RS14440	COG4208	sulfate ABC transporter
DDI_RS14445	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DDI_RS14450	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DDI_RS14455	COG3835	regulator
DDI_RS14465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DDI_RS14470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DDI_RS14475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DDI_RS14490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DDI_RS14495	COG1643	Atp-dependent helicase
DDI_RS14500	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DDI_RS14505	COG1489	DNA binding
DDI_RS14510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DDI_RS14515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DDI_RS14520	COG0617	tRNA 3'-terminal CCA addition
DDI_RS14525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DDI_RS14530	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DDI_RS14535	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DDI_RS14540	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DDI_RS14545	COG0842	Transport permease protein
DDI_RS14550	COG1131	(ABC) transporter
DDI_RS14555	COG0288	reversible hydration of carbon dioxide
DDI_RS14560	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DDI_RS14590	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DDI_RS14595	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DDI_RS14605	COG1780	Probably involved in ribonucleotide reductase function
DDI_RS14610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DDI_RS14615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DDI_RS14625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DDI_RS14635	COG2226	methyltransferase
DDI_RS14640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DDI_RS14645	COG1388	LysM domain
DDI_RS14645	COG0741	lytic transglycosylase activity
DDI_RS14655	COG3021	interspecies interaction between organisms
DDI_RS14695	COG0542	response to heat
DDI_RS14700	COG1496	oxidoreductase activity
DDI_RS14705	COG0564	pseudouridine synthase activity
DDI_RS14710	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DDI_RS14715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DDI_RS14720	COG1605	Chorismate mutase
DDI_RS14720	COG0077	Prephenate dehydratase
DDI_RS14725	COG0287	Prephenate dehydrogenase
DDI_RS14725	COG1605	Chorismate mutase
DDI_RS14730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DDI_RS14745	COG0336	Belongs to the RNA methyltransferase TrmD family
DDI_RS14750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DDI_RS14755	COG0228	four-way junction DNA binding
DDI_RS14760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DDI_RS14765	COG4137	Cytochrome C assembly protein
DDI_RS14770	COG1854	S-ribosylhomocysteine lyase activity
DDI_RS14775	COG2918	glutathione biosynthetic process
DDI_RS14780	COG1238	metal cluster binding
DDI_RS14785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DDI_RS14810	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DDI_RS14815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DDI_RS14820	COG2137	regulation of response to DNA damage stimulus
DDI_RS14825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DDI_RS14830	COG1546	Belongs to the CinA family
DDI_RS14840	COG3038	cytochrome b561
DDI_RS14865	COG1879	ABC-type sugar transport system periplasmic component
DDI_RS14870	COG1129	ABC transporter
DDI_RS14875	COG1172	Belongs to the binding-protein-dependent transport system permease family
DDI_RS14880	COG1172	Belongs to the binding-protein-dependent transport system permease family
DDI_RS14885	COG0688	phosphatidylethanolamine metabolic process
DDI_RS14895	COG2207	Transcriptional regulator
DDI_RS14900	COG0523	cobalamin synthesis protein
DDI_RS14905	COG2879	small protein
DDI_RS14910	COG1966	Carbon starvation protein
DDI_RS14920	COG3275	phosphorelay sensor kinase activity
DDI_RS14930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DDI_RS14940	COG0601	transmembrane transport
DDI_RS14945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS14955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DDI_RS14965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DDI_RS14980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDI_RS14985	COG1696	Membrane protein involved in D-alanine export
DDI_RS15020	COG1857	crispr-associated protein
DDI_RS15030	COG1518	maintenance of DNA repeat elements
DDI_RS15035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DDI_RS15060	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DDI_RS15065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DDI_RS15075	COG2199	diguanylate cyclase activity
DDI_RS15085	COG1073	alpha beta
DDI_RS15090	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DDI_RS15100	COG2195	Cleaves the N-terminal amino acid of tripeptides
DDI_RS15105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DDI_RS15110	COG3034	peptidoglycan biosynthetic process
DDI_RS15115	COG0121	glutamine amidotransferase
DDI_RS15120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DDI_RS15125	COG1960	acyl-CoA dehydrogenase activity
DDI_RS15130	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DDI_RS15135	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DDI_RS15140	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DDI_RS15145	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DDI_RS15150	COG0235	Class ii aldolase
DDI_RS15155	COG0436	Aminotransferase
DDI_RS15170	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DDI_RS15180	COG0765	amino acid transport
DDI_RS15235	COG1953	Uracil, thiamine, allantoin
DDI_RS15245	COG4175	Glycine betaine
DDI_RS15250	COG4176	ABC-type proline glycine betaine transport system permease component
DDI_RS15255	COG2113	Glycine betaine
DDI_RS15260	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DDI_RS15270	COG1846	Transcriptional regulator
DDI_RS15275	COG1566	PFAM secretion protein HlyD family protein
DDI_RS15280	COG2814	Major facilitator Superfamily
DDI_RS15285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DDI_RS15290	COG3118	belongs to the thioredoxin family
DDI_RS15295	COG3148	PFAM DTW domain containing protein
DDI_RS15300	COG1042	CoA-binding domain protein
DDI_RS15300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DDI_RS15300	COG0045	succinate-CoA ligase (ADP-forming) activity
DDI_RS15305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DDI_RS15310	COG5544	Lipoprotein
DDI_RS15315	COG0477	Major facilitator Superfamily
DDI_RS15355	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DDI_RS15360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DDI_RS15365	COG2011	ABC-type metal ion transport system permease component
DDI_RS15370	COG1464	Belongs to the NlpA lipoprotein family
DDI_RS15380	COG1720	tRNA m6t6A37 methyltransferase activity
DDI_RS15385	COG0442	prolyl-tRNA aminoacylation
DDI_RS15395	COG1388	LysM domain
DDI_RS15395	COG4942	peptidase
DDI_RS15400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DDI_RS15405	COG0585	pseudouridine synthase activity
DDI_RS15410	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DDI_RS15415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DDI_RS15430	COG0529	Catalyzes the synthesis of activated sulfate
DDI_RS15435	COG2895	sulfate adenylyltransferase (ATP) activity
DDI_RS15445	COG1648	precorrin-2 dehydrogenase activity
DDI_RS15445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DDI_RS15450	COG0175	sulfate reduction
DDI_RS15455	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DDI_RS15460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DDI_RS15475	COG0720	synthase
DDI_RS15480	COG0602	queuosine metabolic process
DDI_RS15490	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DDI_RS15500	COG0148	phosphopyruvate hydratase activity
DDI_RS15505	COG0504	CTP synthase activity
DDI_RS15510	COG3956	TIGRFAM MazG family protein
DDI_RS15515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DDI_RS15520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DDI_RS15530	COG1929	Belongs to the glycerate kinase type-1 family
DDI_RS15535	COG2084	Dehydrogenase
DDI_RS15545	COG4948	Mandelate Racemase Muconate Lactonizing
DDI_RS15550	COG4948	Mandelate Racemase Muconate Lactonizing
DDI_RS15555	COG2271	Major facilitator Superfamily
DDI_RS15560	COG2721	sulfolactate sulfo-lyase activity
DDI_RS15565	COG0840	transmembrane signaling receptor activity
DDI_RS15585	COG3530	Putative quorum-sensing-regulated virulence factor
DDI_RS15590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DDI_RS15595	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DDI_RS15595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DDI_RS15600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DDI_RS15605	COG3025	triphosphatase activity
DDI_RS15610	COG4991	sh3 domain protein
DDI_RS15615	COG0617	tRNA 3'-terminal CCA addition
DDI_RS15620	COG1968	undecaprenyl-diphosphatase activity
DDI_RS15625	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DDI_RS15630	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DDI_RS15640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DDI_RS15645	COG2105	PFAM AIG2 family protein
DDI_RS15655	COG0729	surface antigen
DDI_RS15660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DDI_RS15670	COG1253	flavin adenine dinucleotide binding
DDI_RS15690	COG0737	Belongs to the 5'-nucleotidase family
DDI_RS15695	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DDI_RS15705	COG0545	Peptidyl-prolyl cis-trans isomerase
DDI_RS15710	COG3061	Opacity-associated protein A
DDI_RS15720	COG0359	binds to the 23S rRNA
DDI_RS15725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DDI_RS15730	COG2965	DNA replication, synthesis of RNA primer
DDI_RS15740	COG1073	alpha beta
DDI_RS15745	COG0840	transmembrane signaling receptor activity
DDI_RS15760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DDI_RS15765	COG0557	exoribonuclease II activity
DDI_RS15770	COG1959	2 iron, 2 sulfur cluster binding
DDI_RS15785	COG0402	S-adenosylhomocysteine deaminase activity
DDI_RS15790	COG2805	Type II/IV secretion system protein
DDI_RS15795	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DDI_RS15800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DDI_RS15805	COG0762	integral membrane protein
DDI_RS15810	COG1872	DUF167
DDI_RS15820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DDI_RS15825	COG5510	response to toxic substance
DDI_RS15830	COG2153	protein acetylation
DDI_RS15835	COG0477	Major facilitator Superfamily
DDI_RS15840	COG0204	Acyl-transferase
DDI_RS15840	COG0318	PFAM AMP-dependent synthetase and ligase
DDI_RS15845	COG2723	6-phospho-beta-galactosidase activity
DDI_RS15850	COG2723	6-phospho-beta-galactosidase activity
DDI_RS15855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DDI_RS15855	COG1263	PTS System
DDI_RS15855	COG2190	(PTS) system
DDI_RS15860	COG3711	transcriptional antiterminator
DDI_RS15870	COG1609	Transcriptional regulator
DDI_RS15885	COG2186	Transcriptional regulator
DDI_RS15890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DDI_RS15895	COG2723	6-phospho-beta-galactosidase activity
DDI_RS15900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DDI_RS15905	COG1447	Phosphotransferase system cellobiose-specific component IIA
DDI_RS15910	COG1609	Transcriptional regulator
DDI_RS15920	COG0583	DNA-binding transcription factor activity
DDI_RS15930	COG3842	ATPase activity
DDI_RS15940	COG4149	molybdate abc transporter
DDI_RS15985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DDI_RS16000	COG2124	cytochrome p450
DDI_RS16015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DDI_RS16030	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DDI_RS16150	COG2369	cell adhesion
DDI_RS16185	COG0741	lytic transglycosylase activity
DDI_RS16235	COG3267	Type II secretory pathway component ExeA
DDI_RS16235	COG3409	Peptidoglycan-binding domain 1 protein
DDI_RS16245	COG4396	Host-nuclease inhibitor protein Gam
DDI_RS16275	COG1522	sequence-specific DNA binding
DDI_RS16285	COG1448	Aminotransferase
DDI_RS16315	COG1203	CRISPR-associated helicase, Cas3
DDI_RS16320	COG1518	maintenance of DNA repeat elements
DDI_RS16330	COG0840	transmembrane signaling receptor activity
DDI_RS16340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DDI_RS16345	COG0629	single-stranded DNA binding
DDI_RS16350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DDI_RS16450	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DDI_RS16455	COG1609	Transcriptional regulator
DDI_RS16460	COG0395	ABC-type sugar transport system, permease component
DDI_RS16465	COG1175	transmembrane transport
DDI_RS16470	COG3842	ATPase activity
DDI_RS16475	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DDI_RS16495	COG2971	BadF BadG BcrA BcrD
DDI_RS16500	COG1121	(ABC) transporter
DDI_RS16505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DDI_RS16510	COG0803	Belongs to the bacterial solute-binding protein 9 family
DDI_RS16520	COG1349	DNA-binding transcription factor activity
DDI_RS16525	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DDI_RS16530	COG3395	kinase activity
DDI_RS16535	COG1454	alcohol dehydrogenase
DDI_RS16540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DDI_RS16555	COG2731	YhcH YjgK YiaL family protein
DDI_RS16565	COG0840	transmembrane signaling receptor activity
DDI_RS16570	COG3112	Uncharacterised protein family (UPF0231)
DDI_RS16585	COG2079	MmgE PrpD family protein
DDI_RS16595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DDI_RS16600	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDI_RS16605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DDI_RS16615	COG1113	amino acid transport
DDI_RS16620	COG3725	Membrane protein required for beta-lactamase induction
DDI_RS16625	COG3023	N-Acetylmuramoyl-L-alanine amidase
DDI_RS16635	COG3248	Nucleoside-binding outer membrane protein
DDI_RS16645	COG4969	Belongs to the N-Me-Phe pilin family
DDI_RS16650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DDI_RS16655	COG1459	type II secretion system
DDI_RS16665	COG0237	dephospho-CoA kinase activity
DDI_RS16670	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DDI_RS16675	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DDI_RS16680	COG0494	nUDIX hydrolase
DDI_RS16685	COG0653	protein targeting
DDI_RS16700	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DDI_RS16705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DDI_RS16710	COG0849	cell division
DDI_RS16715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DDI_RS16720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DDI_RS16725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DDI_RS16730	COG0772	Belongs to the SEDS family
DDI_RS16735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DDI_RS16740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DDI_RS16745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DDI_RS16750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DDI_RS16755	COG0768	penicillin binding
DDI_RS16760	COG3116	cell division
DDI_RS16765	COG0275	rRNA processing
DDI_RS16770	COG2001	Belongs to the MraZ family
DDI_RS16790	COG0028	Belongs to the TPP enzyme family
DDI_RS16795	COG1022	Amp-dependent synthetase and ligase
DDI_RS16800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DDI_RS16805	COG0473	3-isopropylmalate dehydrogenase activity
DDI_RS16815	COG0066	3-isopropylmalate dehydratase activity
DDI_RS16835	COG3033	Beta-eliminating lyase
DDI_RS16845	COG4533	DNA binding
DDI_RS16850	COG4143	(ABC) transporter
DDI_RS16855	COG1178	ABC-type Fe3 transport system permease component
DDI_RS16860	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DDI_RS16870	COG0028	Belongs to the TPP enzyme family
DDI_RS16875	COG0440	acetolactate synthase activity
DDI_RS16880	COG0586	Pfam SNARE associated Golgi protein
DDI_RS16900	COG3157	Type VI secretion system effector, Hcp
DDI_RS16905	COG0417	DNA replication proofreading
DDI_RS16910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DDI_RS16915	COG0564	pseudouridine synthase activity
DDI_RS16920	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DDI_RS16925	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DDI_RS16930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DDI_RS16935	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DDI_RS16940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DDI_RS16945	COG2967	ApaG domain
DDI_RS16950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DDI_RS16955	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DDI_RS16960	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DDI_RS16965	COG3610	response to peptide
DDI_RS16970	COG2966	Psort location CytoplasmicMembrane, score
DDI_RS16975	COG1280	lysine exporter protein (LysE YggA)
DDI_RS16980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DDI_RS16985	COG0505	Belongs to the CarA family
DDI_RS17000	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DDI_RS17005	COG1047	Peptidyl-prolyl cis-trans
DDI_RS17010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DDI_RS17015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DDI_RS17020	COG0196	riboflavin kinase activity
DDI_RS17030	COG0268	Binds directly to 16S ribosomal RNA
DDI_RS17035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DDI_RS17040	COG0484	heat shock protein binding
DDI_RS17050	COG1584	GPR1 FUN34 yaaH family protein
DDI_RS17060	COG0521	Mo-molybdopterin cofactor biosynthetic process
DDI_RS17065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DDI_RS17070	COG3022	response to hydroperoxide
DDI_RS17080	COG0083	homoserine kinase activity
DDI_RS17090	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DDI_RS17095	COG0745	RESPONSE REGULATOR receiver
DDI_RS17100	COG3045	CreA protein
DDI_RS17105	COG2207	Transcriptional regulator
DDI_RS17105	COG3708	Transcriptional regulator
DDI_RS17110	COG0406	alpha-ribazole phosphatase activity
DDI_RS17115	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DDI_RS17120	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
DDI_RS17130	COG0488	(ABC) transporter
DDI_RS17135	COG0840	transmembrane signaling receptor activity
DDI_RS17140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DDI_RS17145	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DDI_RS17150	COG0583	DNA-binding transcription factor activity
DDI_RS17155	COG2968	Membrane
DDI_RS17160	COG1414	Transcriptional regulator
DDI_RS17165	COG0668	transmembrane transport
DDI_RS17175	COG0126	phosphoglycerate kinase activity
DDI_RS17180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DDI_RS17185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DDI_RS17190	COG0738	Major facilitator superfamily
DDI_RS17195	COG1166	arginine decarboxylase activity
DDI_RS17205	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DDI_RS17210	COG3091	SprT-like family
DDI_RS17215	COG2356	endonuclease I
DDI_RS17220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DDI_RS17225	COG0189	ligase activity
DDI_RS17230	COG1678	Uncharacterized ACR, COG1678
DDI_RS17235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DDI_RS17240	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DDI_RS17245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DDI_RS17250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DDI_RS17255	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
DDI_RS17260	COG0330	HflC and HflK could
DDI_RS17265	COG0330	HflC and HflK could
DDI_RS17270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DDI_RS17275	COG1923	regulation of RNA biosynthetic process
DDI_RS17280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DDI_RS17285	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DDI_RS17295	COG0802	atpase or kinase
DDI_RS17300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DDI_RS17300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DDI_RS17305	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DDI_RS17325	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DDI_RS17340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DDI_RS17370	COG0765	amino acid transport
DDI_RS17380	COG4221	oxidoreductase activity
DDI_RS17395	COG0436	Aminotransferase
DDI_RS17400	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DDI_RS17405	COG1984	allophanate hydrolase subunit 2
DDI_RS17420	COG0697	spore germination
DDI_RS17430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDI_RS17435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDI_RS17455	COG0765	amino acid transport
DDI_RS17460	COG1126	abc transporter atp-binding protein
DDI_RS17465	COG1764	response to oxidative stress
DDI_RS17470	COG1846	Transcriptional regulator
DDI_RS17475	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DDI_RS17480	COG1473	amidohydrolase
DDI_RS17490	COG0583	DNA-binding transcription factor activity
DDI_RS17510	COG3604	Transcriptional regulator
DDI_RS17515	COG2205	protein histidine kinase activity
DDI_RS17580	COG0840	transmembrane signaling receptor activity
DDI_RS17590	COG3550	peptidyl-serine autophosphorylation
DDI_RS17695	COG4221	oxidoreductase activity
DDI_RS17695	COG3321	synthase
DDI_RS17695	COG1028	Short-chain dehydrogenase reductase Sdr
DDI_RS17695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDI_RS17700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDI_RS17710	COG3119	arylsulfatase activity
DDI_RS17715	COG0583	DNA-binding transcription factor activity
DDI_RS17740	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DDI_RS17745	COG1162	GTPase activity
DDI_RS17750	COG0688	phosphatidylethanolamine metabolic process
DDI_RS17755	COG1511	domain protein
DDI_RS17755	COG3264	Mechanosensitive ion channel
DDI_RS17765	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DDI_RS17770	COG1053	succinate dehydrogenase
DDI_RS17775	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DDI_RS17780	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
DDI_RS17785	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
DDI_RS17795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DDI_RS17800	COG1509	lysine 2,3-aminomutase activity
DDI_RS17810	COG0166	Belongs to the GPI family
DDI_RS17815	COG0527	aspartate kinase activity
DDI_RS17820	COG1283	sodium-dependent phosphate transmembrane transporter activity
DDI_RS17825	COG0471	metal ion transport
DDI_RS17850	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DDI_RS17860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DDI_RS17865	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DDI_RS17895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DDI_RS17905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DDI_RS17910	COG0009	L-threonylcarbamoyladenylate synthase
DDI_RS17915	COG0551	DNA topoisomerase type I activity
DDI_RS17920	COG2922	Belongs to the Smg family
DDI_RS17925	COG0758	DNA mediated transformation
DDI_RS17930	COG0242	peptide deformylase activity
DDI_RS17935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DDI_RS17940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DDI_RS17940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DDI_RS17950	COG1970	mechanosensitive ion channel activity
DDI_RS17955	COG3036	rescue of stalled ribosome
DDI_RS17965	COG0203	ribosomal protein L17
DDI_RS17975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DDI_RS17985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DDI_RS17990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DDI_RS17995	COG0201	protein transport
DDI_RS18000	COG0200	Binds to the 23S rRNA
DDI_RS18005	COG1841	ribosomal large subunit assembly
DDI_RS18010	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DDI_RS18020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DDI_RS18030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DDI_RS18035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DDI_RS18040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DDI_RS18050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DDI_RS18055	COG0255	Belongs to the universal ribosomal protein uL29 family
DDI_RS18060	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DDI_RS18070	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DDI_RS18075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DDI_RS18080	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DDI_RS18085	COG0089	rRNA binding
DDI_RS18090	COG0088	Forms part of the polypeptide exit tunnel
DDI_RS18095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DDI_RS18100	COG0051	transcription antitermination factor activity, RNA binding
DDI_RS18115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DDI_RS18120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DDI_RS18125	COG0049	tRNA binding
DDI_RS18130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DDI_RS18135	COG2168	tRNA wobble position uridine thiolation
DDI_RS18140	COG2923	Belongs to the DsrF TusC family
DDI_RS18145	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DDI_RS18150	COG2964	Protein conserved in bacteria
DDI_RS18155	COG2194	sulfuric ester hydrolase activity
DDI_RS18160	COG0745	RESPONSE REGULATOR receiver
DDI_RS18165	COG0642	Histidine kinase
DDI_RS18170	COG1126	abc transporter atp-binding protein
DDI_RS18175	COG0765	amino acid transport
DDI_RS18185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DDI_RS18200	COG0545	Peptidyl-prolyl cis-trans isomerase
DDI_RS18205	COG2900	Belongs to the SlyX family
DDI_RS18215	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DDI_RS18225	COG1047	Peptidyl-prolyl cis-trans
DDI_RS18230	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DDI_RS18235	COG0475	glutathione-regulated potassium exporter activity
DDI_RS18235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DDI_RS18240	COG2249	NAD(P)H dehydrogenase (quinone) activity
DDI_RS18245	COG0488	(ABC) transporter
DDI_RS18260	COG3954	Phosphoribulokinase
DDI_RS18265	COG1765	OsmC-like protein
DDI_RS18285	COG4753	response regulator
DDI_RS18285	COG2207	Transcriptional regulator
DDI_RS18295	COG1404	Belongs to the peptidase S8 family
DDI_RS18300	COG3179	chitinase
DDI_RS18340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DDI_RS18345	COG4948	Mandelate Racemase Muconate Lactonizing
DDI_RS18355	COG0546	phosphoglycolate phosphatase activity
DDI_RS18360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DDI_RS18375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DDI_RS18380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DDI_RS18385	COG4796	Type ii and iii secretion system protein
DDI_RS18410	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DDI_RS18415	COG0494	nUDIX hydrolase
DDI_RS18425	COG1011	Hydrolase
DDI_RS18430	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DDI_RS18440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DDI_RS18445	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DDI_RS18460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DDI_RS18475	COG2183	response to ionizing radiation
DDI_RS18480	COG2267	carboxylic ester hydrolase activity
DDI_RS18490	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DDI_RS18490	COG0316	Belongs to the HesB IscA family
DDI_RS18495	COG1640	4-alpha-glucanotransferase
DDI_RS18500	COG0058	SHG alpha-glucan phosphorylase activity
DDI_RS18505	COG1349	DNA-binding transcription factor activity
DDI_RS18510	COG0705	Rhomboid family
DDI_RS18515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DDI_RS18520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DDI_RS18525	COG0058	SHG alpha-glucan phosphorylase activity
DDI_RS18530	COG0297	glycogen (starch) synthase activity
DDI_RS18535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DDI_RS18550	COG3275	phosphorelay sensor kinase activity
DDI_RS18555	COG1278	Cold shock
DDI_RS18565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DDI_RS18570	COG2095	MarC family integral membrane protein
DDI_RS18575	COG2610	gluconate transmembrane transporter activity
DDI_RS18580	COG3265	gluconokinase activity
DDI_RS18585	COG1609	Transcriptional regulator
DDI_RS18595	COG1741	Belongs to the pirin family
DDI_RS18605	COG0247	lactate metabolic process
DDI_RS18610	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
DDI_RS18615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DDI_RS18620	COG2271	Major facilitator Superfamily
DDI_RS18625	COG0561	phosphatase activity
DDI_RS18630	COG2267	carboxylic ester hydrolase activity
DDI_RS18635	COG1280	lysine exporter protein (LysE YggA)
DDI_RS18640	COG1280	lysine exporter protein (LysE YggA)
DDI_RS18645	COG0514	ATP-dependent DNA helicase (RecQ)
DDI_RS18655	COG2050	protein possibly involved in aromatic compounds catabolism
DDI_RS18665	COG3180	Ammonia monooxygenase
DDI_RS18670	COG0598	Magnesium transport protein CorA
DDI_RS18680	COG1011	Hydrolase
DDI_RS18695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DDI_RS18715	COG0181	hydroxymethylbilane synthase activity
DDI_RS18720	COG1587	Uroporphyrinogen-III synthase
DDI_RS18725	COG2959	enzyme of heme biosynthesis
DDI_RS18730	COG3071	HemY protein
DDI_RS18735	COG1473	amidohydrolase
DDI_RS18740	COG1126	abc transporter atp-binding protein
DDI_RS18745	COG0765	amino acid transport
DDI_RS18750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDI_RS18755	COG0456	acetyltransferase
DDI_RS18760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DDI_RS18770	COG0371	Dehydrogenase
DDI_RS18775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDI_RS18805	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DDI_RS18815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DDI_RS18820	COG2244	polysaccharide biosynthetic process
DDI_RS18825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DDI_RS18835	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DDI_RS18840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DDI_RS18845	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
DDI_RS18850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DDI_RS18855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DDI_RS18860	COG3118	belongs to the thioredoxin family
DDI_RS18870	COG0248	Ppx GppA phosphatase
DDI_RS18890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DDI_RS18895	COG0506	proline dehydrogenase activity
DDI_RS18895	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DDI_RS18895	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DDI_RS18900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DDI_RS18905	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DDI_RS18925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DDI_RS18930	COG0129	dihydroxy-acid dehydratase activity
DDI_RS18940	COG3978	acetolactate synthase activity
DDI_RS18955	COG2814	Major facilitator Superfamily
DDI_RS18965	COG3085	chromosome segregation
DDI_RS18970	COG0583	DNA-binding transcription factor activity
DDI_RS19015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DDI_RS19025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DDI_RS19035	COG1309	transcriptional regulator
DDI_RS19040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DDI_RS19050	COG0678	peroxiredoxin activity
DDI_RS19050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DDI_RS19060	COG0460	homoserine dehydrogenase
DDI_RS19060	COG0527	aspartate kinase activity
DDI_RS19065	COG0626	cystathionine gamma-synthase activity
DDI_RS19070	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
DDI_RS19080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DDI_RS19085	COG1609	Transcriptional regulator
DDI_RS19090	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DDI_RS19095	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DDI_RS19100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DDI_RS19105	COG1575	Belongs to the MenA family. Type 1 subfamily
DDI_RS19110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DDI_RS19115	COG3074	FtsZ-dependent cytokinesis
DDI_RS19120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DDI_RS19130	COG1494	fructose-1,6-bisphosphatase
DDI_RS19140	COG3152	Membrane
DDI_RS19150	COG0149	triose-phosphate isomerase activity
DDI_RS19160	COG2957	Belongs to the agmatine deiminase family
DDI_RS19165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DDI_RS19170	COG0205	6-phosphofructokinase activity
DDI_RS19175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DDI_RS19210	COG3678	ATP-independent chaperone mediated protein folding
DDI_RS19215	COG0745	RESPONSE REGULATOR receiver
DDI_RS19220	COG2205	protein histidine kinase activity
DDI_RS19235	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DDI_RS19245	COG0679	Auxin Efflux Carrier
DDI_RS19250	COG0584	glycerophosphoryl diester phosphodiesterase
DDI_RS19255	COG3842	ATPase activity
DDI_RS19260	COG0395	ABC-type sugar transport system, permease component
DDI_RS19265	COG1175	transmembrane transport
DDI_RS19270	COG1653	transport
DDI_RS19280	COG0840	transmembrane signaling receptor activity
DDI_RS19285	COG0840	transmembrane signaling receptor activity
DDI_RS19290	COG0840	transmembrane signaling receptor activity
DDI_RS19295	COG0840	transmembrane signaling receptor activity
DDI_RS19325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDI_RS19335	COG4177	L-phenylalanine transmembrane transporter activity
DDI_RS19340	COG0559	Belongs to the binding-protein-dependent transport system permease family
DDI_RS19345	COG0683	leucine binding
DDI_RS19350	COG0456	acetyltransferase
DDI_RS19360	COG2177	Part of the ABC transporter FtsEX involved in
DDI_RS19365	COG2884	Cell division ATP-binding protein ftsE
DDI_RS19370	COG0552	protein localization to endoplasmic reticulum
DDI_RS19370	COG0552	protein localization to endoplasmic reticulum
DDI_RS19375	COG0742	ribosomal rna small subunit methyltransferase
DDI_RS19380	COG3776	membrane
DDI_RS19390	COG3714	YhhN family
DDI_RS19395	COG0425	Belongs to the sulfur carrier protein TusA family
DDI_RS19400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DDI_RS19410	COG0477	Major facilitator Superfamily
DDI_RS19420	COG1295	ribonuclease BN
DDI_RS19425	COG1942	4-Oxalocrotonate Tautomerase
DDI_RS19430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDI_RS19455	COG1301	dicarboxylic acid transport
DDI_RS19460	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DDI_RS19470	COG0457	Tetratricopeptide repeat
DDI_RS19480	COG1215	transferase activity, transferring glycosyl groups
DDI_RS19485	COG0489	protein tyrosine kinase activity
DDI_RS19505	COG4608	Belongs to the ABC transporter superfamily
DDI_RS19510	COG0444	Belongs to the ABC transporter superfamily
DDI_RS19515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS19520	COG0601	transmembrane transport
DDI_RS19525	COG0747	negative chemotaxis
DDI_RS19530	COG3493	citrate carrier protein
DDI_RS19535	COG4565	transcriptional regulatory protein
DDI_RS19540	COG3290	protein histidine kinase activity
DDI_RS19545	COG0471	metal ion transport
DDI_RS19555	COG0071	Belongs to the small heat shock protein (HSP20) family
DDI_RS19560	COG0071	Belongs to the small heat shock protein (HSP20) family
DDI_RS19565	COG5645	(Lipo)protein
DDI_RS19570	COG0477	Major facilitator Superfamily
DDI_RS19595	COG0561	phosphatase activity
DDI_RS19600	COG0589	response to stress
DDI_RS19610	COG0306	phosphate transporter
DDI_RS19615	COG2081	HI0933 family
DDI_RS19620	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DDI_RS19640	COG3842	ATPase activity
DDI_RS19645	COG3833	ABC-type maltose transport systems, permease component
DDI_RS19685	COG1653	transport
DDI_RS19690	COG3833	ABC-type maltose transport systems, permease component
DDI_RS19695	COG1175	transmembrane transport
DDI_RS19705	COG2814	Major facilitator Superfamily
DDI_RS19710	COG0583	DNA-binding transcription factor activity
DDI_RS19720	COG4221	oxidoreductase activity
DDI_RS19735	COG2194	sulfuric ester hydrolase activity
DDI_RS19740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DDI_RS19745	COG0194	GDP metabolic process
DDI_RS19755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DDI_RS19760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DDI_RS19765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DDI_RS19770	COG2233	PERMEase
DDI_RS19780	COG2982	Protein involved in outer membrane biogenesis
DDI_RS19785	COG0456	acetyltransferase
DDI_RS19790	COG1490	D-aminoacyl-tRNA deacylase activity
DDI_RS19795	COG1011	Hydrolase
DDI_RS19800	COG1217	gtp-binding protein TYPA
DDI_RS19815	COG3852	Histidine kinase
DDI_RS19835	COG3078	GTPase activator activity
DDI_RS19840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DDI_RS19845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DDI_RS19845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DDI_RS19850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DDI_RS19855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DDI_RS19860	COG3084	Protein conserved in bacteria
DDI_RS19870	COG1763	Mo-molybdopterin cofactor biosynthetic process
DDI_RS19900	COG1609	Transcriptional regulator
DDI_RS19905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDI_RS19910	COG1879	ABC-type sugar transport system periplasmic component
DDI_RS19915	COG1172	Belongs to the binding-protein-dependent transport system permease family
DDI_RS19920	COG1129	ABC transporter
DDI_RS19925	COG1869	D-ribose catabolic process
DDI_RS19930	COG3111	PFAM Bacterial OB fold (BOF) protein
DDI_RS19935	COG0745	RESPONSE REGULATOR receiver
DDI_RS19945	COG3158	transport of potassium into the cell
DDI_RS19950	COG0714	Associated with various cellular activities
DDI_RS19955	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DDI_RS19960	COG1522	sequence-specific DNA binding
DDI_RS19965	COG0716	FMN binding
DDI_RS19970	COG0445	tRNA wobble uridine modification
DDI_RS19975	COG0357	Ribosomal RNA small subunit methyltransferase G
DDI_RS19980	COG3312	ion transport
DDI_RS19985	COG0356	it plays a direct role in the translocation of protons across the membrane
DDI_RS19995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DDI_RS20000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DDI_RS20005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DDI_RS20010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DDI_RS20015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DDI_RS20020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DDI_RS20030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DDI_RS20035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DDI_RS20060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDI_RS20065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDI_RS20120	COG1028	Short-chain dehydrogenase reductase Sdr
DDI_RS20130	COG3706	GGDEF domain
DDI_RS20140	COG0003	Pfam Anion-transporting ATPase
DDI_RS20150	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DDI_RS20155	COG0573	inorganic phosphate transmembrane transporter activity
DDI_RS20160	COG0581	inorganic phosphate transmembrane transporter activity
DDI_RS20165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DDI_RS20175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDI_RS20190	COG0765	amino acid transport
DDI_RS20195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DDI_RS20200	COG2252	PERMEase
DDI_RS20205	COG2091	lysine biosynthetic process via aminoadipic acid
DDI_RS20210	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DDI_RS20215	COG0493	'glutamate synthase
DDI_RS20215	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DDI_RS20220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DDI_RS20225	COG0463	Glycosyl transferase, family 2
DDI_RS20230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DDI_RS20230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DDI_RS20235	COG0726	polysaccharide deacetylase
DDI_RS20240	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DDI_RS20245	COG2076	Multidrug Resistance protein
DDI_RS20250	COG2076	Multidrug Resistance protein
DDI_RS20265	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DDI_RS20275	COG1396	sequence-specific DNA binding
DDI_RS20290	COG1309	transcriptional regulator
DDI_RS20295	COG4221	oxidoreductase activity
DDI_RS20305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DDI_RS20310	COG0706	membrane insertase activity
DDI_RS20315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DDI_RS20320	COG0594	ribonuclease P activity
DDI_RS20325	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DDI_RS20335	COG0592	DNA-directed DNA polymerase activity
DDI_RS20340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DDI_RS20345	COG0187	DNA topoisomerase II activity
DDI_RS20355	COG0742	ribosomal rna small subunit methyltransferase
DDI_RS20370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DDI_RS20375	COG1234	tRNA 3'-trailer cleavage
DDI_RS20380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DDI_RS20390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DDI_RS20395	COG2188	Transcriptional regulator
DDI_RS20405	COG1696	Membrane protein involved in D-alanine export
DDI_RS20425	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DDI_RS20430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DDI_RS20435	COG4191	Histidine kinase
DDI_RS20455	COG0583	DNA-binding transcription factor activity
DDI_RS20475	COG0837	glucose binding
DDI_RS20485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDI_RS20490	COG4172	Belongs to the ABC transporter superfamily
DDI_RS20495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS20500	COG0601	transmembrane transport
DDI_RS20505	COG0747	negative chemotaxis
DDI_RS20515	COG3977	Valine--pyruvate aminotransferase
DDI_RS20525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DDI_RS20530	COG0456	acetyltransferase
DDI_RS20535	COG2818	Glycosylase
DDI_RS20540	COG0730	response to heat
DDI_RS20550	COG0751	glycine-tRNA ligase activity
DDI_RS20575	COG3842	ATPase activity
DDI_RS20595	COG2213	PTS system mannitol-specific
DDI_RS20595	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DDI_RS20600	COG0246	Mannitol dehydrogenase
DDI_RS20605	COG3722	fumarate hydratase activity
DDI_RS20610	COG0840	transmembrane signaling receptor activity
DDI_RS20615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DDI_RS20620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DDI_RS20625	COG1012	belongs to the aldehyde dehydrogenase family
DDI_RS20630	COG1070	Carbohydrate kinase
DDI_RS20635	COG2115	Belongs to the xylose isomerase family
DDI_RS20645	COG4213	ABC transporter substrate-binding protein
DDI_RS20650	COG1129	ABC transporter
DDI_RS20655	COG4214	carbohydrate transport
DDI_RS20660	COG1609	Transcriptional regulator
DDI_RS20660	COG2207	Transcriptional regulator
DDI_RS20685	COG0137	argininosuccinate synthase activity
DDI_RS20690	COG1846	Transcriptional regulator
DDI_RS20695	COG0697	spore germination
DDI_RS20700	COG2313	pseudouridylate synthase activity
DDI_RS20710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDI_RS20745	COG1136	(ABC) transporter
DDI_RS20750	COG0577	efflux transmembrane transporter activity
DDI_RS20750	COG1136	(ABC) transporter
DDI_RS20765	COG2091	lysine biosynthetic process via aminoadipic acid
DDI_RS20790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DDI_RS20800	COG1960	acyl-CoA dehydrogenase activity
DDI_RS20810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDI_RS20825	COG0318	PFAM AMP-dependent synthetase and ligase
DDI_RS20845	COG2771	luxR family
DDI_RS20870	COG3423	Transcriptional regulator
DDI_RS20900	COG1561	YicC-like family, N-terminal region
DDI_RS20905	COG0583	DNA-binding transcription factor activity
DDI_RS20915	COG0747	negative chemotaxis
DDI_RS20920	COG0601	transmembrane transport
DDI_RS20925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS20930	COG0444	Belongs to the ABC transporter superfamily
DDI_RS20935	COG4608	Belongs to the ABC transporter superfamily
DDI_RS20980	COG1136	(ABC) transporter
DDI_RS20980	COG0577	efflux transmembrane transporter activity
DDI_RS20985	COG1136	(ABC) transporter
DDI_RS20985	COG0577	efflux transmembrane transporter activity
DDI_RS21020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDI_RS21025	COG0601	transmembrane transport
DDI_RS21030	COG0747	negative chemotaxis
DDI_RS21035	COG4172	Belongs to the ABC transporter superfamily
DDI_RS21040	COG4948	Mandelate Racemase Muconate Lactonizing
DDI_RS21055	COG2149	membrane
DDI_RS21060	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DDI_RS21065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DDI_RS21070	COG1309	transcriptional regulator
DDI_RS21080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DDI_RS21085	COG2003	Belongs to the UPF0758 family
DDI_RS21100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DDI_RS21105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DDI_RS21115	COG1519	Transferase
DDI_RS21120	COG0438	transferase activity, transferring glycosyl groups
DDI_RS21140	COG0859	PFAM glycosyl transferase family 9
DDI_RS21145	COG0859	PFAM glycosyl transferase family 9
DDI_RS21150	COG0859	PFAM glycosyl transferase family 9
DDI_RS21155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DDI_RS21160	COG2861	carbohydrate metabolic process
DDI_RS21165	COG4942	peptidase
DDI_RS21170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DDI_RS21175	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DDI_RS21180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DDI_RS21185	COG1045	serine acetyltransferase
DDI_RS21200	COG0583	DNA-binding transcription factor activity
DDI_RS21205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DDI_RS21215	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DDI_RS21220	COG2365	Tyrosine phosphatase family
DDI_RS21225	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DDI_RS21230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DDI_RS21235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DDI_RS21240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DDI_RS21245	COG0165	Argininosuccinate lyase
DDI_RS21250	COG1322	Protein conserved in bacteria
DDI_RS21255	COG2226	methyltransferase
DDI_RS21260	COG3165	ubiquinone biosynthetic process from chorismate
DDI_RS21265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DDI_RS21280	COG0805	protein transport
DDI_RS21285	COG0084	hydrolase, TatD family'
DDI_RS21300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DDI_RS21310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DDI_RS21330	COG0183	Belongs to the thiolase family
DDI_RS21335	COG1024	Enoyl-CoA hydratase
DDI_RS21335	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDI_RS21340	COG0006	proline dipeptidase activity
DDI_RS21345	COG1739	Uncharacterized protein family UPF0029
DDI_RS21350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DDI_RS21395	COG1072	(Pantothenic acid kinase))
DDI_RS21420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DDI_RS21430	COG0250	Participates in transcription elongation, termination and antitermination
DDI_RS21435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DDI_RS21440	COG0081	regulation of translation
DDI_RS21485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDI_RS21495	COG2022	thiamine diphosphate biosynthetic process
DDI_RS21500	COG2104	thiamine diphosphate biosynthetic process
DDI_RS21505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DDI_RS21510	COG0352	thiamine-phosphate diphosphorylase activity
DDI_RS21515	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DDI_RS21520	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
DDI_RS21525	COG2816	NAD+ diphosphatase activity
DDI_RS21530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DDI_RS21535	COG1515	deoxyribonuclease V activity
DDI_RS21555	COG0151	Belongs to the GarS family
DDI_RS21560	COG0138	bifunctional purine biosynthesis protein purh