locus-tag	class	description
A4U42_RS00010	COG2840	Smr protein MutS2
A4U42_RS00030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A4U42_RS00075	COG0402	S-adenosylhomocysteine deaminase activity
A4U42_RS00085	COG0840	transmembrane signaling receptor activity
A4U42_RS00090	COG0840	transmembrane signaling receptor activity
A4U42_RS00100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4U42_RS00105	COG0038	chloride channel
A4U42_RS00115	COG4172	Belongs to the ABC transporter superfamily
A4U42_RS00120	COG0444	Belongs to the ABC transporter superfamily
A4U42_RS00125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS00130	COG0601	transmembrane transport
A4U42_RS00135	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A4U42_RS00140	COG0387	Pfam Sodium calcium exchanger
A4U42_RS00145	COG0659	secondary active sulfate transmembrane transporter activity
A4U42_RS00155	COG0745	RESPONSE REGULATOR receiver
A4U42_RS00160	COG2205	protein histidine kinase activity
A4U42_RS00170	COG3591	Belongs to the peptidase S1B family
A4U42_RS00175	COG1620	l-lactate permease
A4U42_RS00180	COG0247	lactate metabolic process
A4U42_RS00185	COG1139	Iron-sulfur cluster binding protein
A4U42_RS00190	COG1556	Lactate utilization protein
A4U42_RS00195	COG1643	Atp-dependent helicase
A4U42_RS00200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A4U42_RS00210	COG2911	Protein conserved in bacteria
A4U42_RS00215	COG0840	transmembrane signaling receptor activity
A4U42_RS00220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4U42_RS00230	COG0840	transmembrane signaling receptor activity
A4U42_RS00255	COG0037	tRNA processing
A4U42_RS00260	COG0598	Magnesium transport protein CorA
A4U42_RS00265	COG4166	transmembrane transport
A4U42_RS00270	COG2866	Carboxypeptidase
A4U42_RS00275	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A4U42_RS00280	COG0477	Major facilitator Superfamily
A4U42_RS00305	COG1902	pentaerythritol trinitrate reductase activity
A4U42_RS00310	COG0583	DNA-binding transcription factor activity
A4U42_RS00325	COG2271	Major facilitator Superfamily
A4U42_RS00330	COG3768	UPF0283 membrane protein
A4U42_RS00335	COG3106	COG3106 Predicted ATPase
A4U42_RS00340	COG1983	PspC domain protein
A4U42_RS00350	COG1842	Phage shock protein A
A4U42_RS00355	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A4U42_RS00365	COG4166	transmembrane transport
A4U42_RS00370	COG4168	peptide transport system, permease
A4U42_RS00380	COG4172	Belongs to the ABC transporter superfamily
A4U42_RS00400	COG0243	molybdopterin cofactor binding
A4U42_RS00405	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A4U42_RS00410	COG4989	oxidoreductase activity
A4U42_RS00415	COG1966	Carbon starvation protein
A4U42_RS00435	COG0023	Translation Initiation Factor
A4U42_RS00445	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A4U42_RS00450	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A4U42_RS00455	COG0671	phosphoesterase, PA-phosphatase related
A4U42_RS00475	COG0625	glutathione transferase activity
A4U42_RS00480	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A4U42_RS00490	COG0259	pyridoxamine-phosphate oxidase activity
A4U42_RS00495	COG3895	Periplasmic Protein
A4U42_RS00500	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A4U42_RS00515	COG0346	lactoylglutathione lyase activity
A4U42_RS00520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4U42_RS00525	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A4U42_RS00530	COG0791	NLP P60 protein
A4U42_RS00535	COG1609	Transcriptional regulator
A4U42_RS00540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4U42_RS00545	COG0307	riboflavin synthase, alpha
A4U42_RS00550	COG0534	Mate efflux family protein
A4U42_RS00565	COG2382	esterase
A4U42_RS00595	COG4238	major outer membrane lipoprotein
A4U42_RS00600	COG1388	LysM domain
A4U42_RS00600	COG1376	ErfK ybiS ycfS ynhG family protein
A4U42_RS00605	COG2166	iron-sulfur cluster assembly
A4U42_RS00610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4U42_RS00615	COG0719	Fe-S assembly protein
A4U42_RS00620	COG0396	ATPase activity
A4U42_RS00625	COG0719	Fe-S assembly protein
A4U42_RS00630	COG0316	Belongs to the HesB IscA family
A4U42_RS00640	COG2050	protein possibly involved in aromatic compounds catabolism
A4U42_RS00645	COG0277	FAD linked oxidase domain protein
A4U42_RS00645	COG0247	lactate metabolic process
A4U42_RS00650	COG0628	permease
A4U42_RS00660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4U42_RS00660	COG0574	Belongs to the PEP-utilizing enzyme family
A4U42_RS00665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A4U42_RS00670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4U42_RS00675	COG3009	Protein conserved in bacteria
A4U42_RS00680	COG3008	intermembrane lipid transfer
A4U42_RS00680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4U42_RS00685	COG2995	paraquat-inducible protein a
A4U42_RS00690	COG0488	(ABC) transporter
A4U42_RS00695	COG0116	Belongs to the methyltransferase superfamily
A4U42_RS00695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4U42_RS00700	COG3217	Mosc domain protein beta barrel domain protein
A4U42_RS00700	COG0633	Ferredoxin
A4U42_RS00710	COG0167	dihydroorotate dehydrogenase activity
A4U42_RS00715	COG0431	NADPH-dependent FMN reductase
A4U42_RS00720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4U42_RS00725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U42_RS00730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U42_RS00735	COG1116	anion transmembrane transporter activity
A4U42_RS00740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4U42_RS00750	COG0308	aminopeptidase N
A4U42_RS00755	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A4U42_RS00760	COG0017	Asparaginyl-tRNA synthetase
A4U42_RS00780	COG1448	Aminotransferase
A4U42_RS00785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4U42_RS00790	COG3108	Peptidase M15
A4U42_RS00795	COG2989	Protein conserved in bacteria
A4U42_RS00800	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A4U42_RS00810	COG0095	Lipoate-protein ligase
A4U42_RS00815	COG0791	NLP P60 protein
A4U42_RS00820	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
A4U42_RS00825	COG0386	Belongs to the glutathione peroxidase family
A4U42_RS00830	COG4139	cobalamin transport
A4U42_RS00850	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4U42_RS00855	COG1136	(ABC) transporter
A4U42_RS00860	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4U42_RS00865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4U42_RS00875	COG2200	EAL domain
A4U42_RS00880	COG0443	Heat shock 70 kDa protein
A4U42_RS00895	COG2271	Major facilitator Superfamily
A4U42_RS00900	COG1609	Transcriptional regulator
A4U42_RS00905	COG3134	Outer membrane lipoprotein
A4U42_RS00910	COG1252	NADH dehydrogenase
A4U42_RS00920	COG1472	Belongs to the glycosyl hydrolase 3 family
A4U42_RS00930	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
A4U42_RS00935	COG5633	Lipoprotein
A4U42_RS00940	COG0537	adenosine 5'-monophosphoramidase activity
A4U42_RS00945	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4U42_RS00950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U42_RS00950	COG1263	PTS System
A4U42_RS00955	COG0084	hydrolase, TatD family'
A4U42_RS00960	COG0470	DNA polymerase III
A4U42_RS00965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4U42_RS00970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4U42_RS00975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4U42_RS00980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4U42_RS00985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4U42_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS01000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4U42_RS01005	COG0416	fatty acid biosynthetic process
A4U42_RS01010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4U42_RS01015	COG1399	metal-binding, possibly nucleic acid-binding protein
A4U42_RS01020	COG0424	maF-like protein
A4U42_RS01025	COG0564	pseudouridine synthase activity
A4U42_RS01030	COG1530	ribonuclease E activity
A4U42_RS01040	COG0418	dihydroorotase activity
A4U42_RS01055	COG3038	cytochrome b561
A4U42_RS01065	COG1054	Belongs to the UPF0176 family
A4U42_RS01070	COG1902	pentaerythritol trinitrate reductase activity
A4U42_RS01075	COG1560	Kdo2-lipid A biosynthetic process
A4U42_RS01080	COG2814	Major facilitator Superfamily
A4U42_RS01085	COG2943	transferase activity, transferring hexosyl groups
A4U42_RS01090	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A4U42_RS01100	COG0840	transmembrane signaling receptor activity
A4U42_RS01115	COG1067	ATP-dependent peptidase activity
A4U42_RS01120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4U42_RS01130	COG1012	belongs to the aldehyde dehydrogenase family
A4U42_RS01155	COG1702	phosphate starvation-inducible protein PhoH
A4U42_RS01165	COG1191	sigma factor activity
A4U42_RS01180	COG0673	inositol 2-dehydrogenase activity
A4U42_RS01195	COG0500	methyltransferase
A4U42_RS01205	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A4U42_RS01220	COG1677	Flagellar hook-basal body complex protein FliE
A4U42_RS01235	COG1317	bacterial-type flagellum organization
A4U42_RS01240	COG1157	protein secretion by the type III secretion system
A4U42_RS01255	COG1580	Controls the rotational direction of flagella during chemotaxis
A4U42_RS01290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A4U42_RS01295	COG1256	bacterial-type flagellum assembly
A4U42_RS01305	COG1706	bacterial-type flagellum-dependent cell motility
A4U42_RS01310	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A4U42_RS01320	COG4787	bacterial-type flagellum-dependent cell motility
A4U42_RS01325	COG1749	Flagellar hook protein flgE
A4U42_RS01330	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A4U42_RS01335	COG1558	bacterial-type flagellum-dependent cell motility
A4U42_RS01340	COG1815	bacterial-type flagellum-dependent cell motility
A4U42_RS01350	COG2747	anti-sigma28 factor FlgM
A4U42_RS01365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A4U42_RS01370	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A4U42_RS01375	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A4U42_RS01380	COG0745	RESPONSE REGULATOR receiver
A4U42_RS01385	COG2201	protein-glutamate methylesterase activity
A4U42_RS01390	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A4U42_RS01395	COG0840	transmembrane signaling receptor activity
A4U42_RS01400	COG0835	chemotaxis
A4U42_RS01405	COG2198	Histidine kinase
A4U42_RS01405	COG0643	Histidine kinase
A4U42_RS01410	COG1360	Flagellar Motor Protein
A4U42_RS01430	COG1979	alcohol dehydrogenase
A4U42_RS01435	COG0840	transmembrane signaling receptor activity
A4U42_RS01450	COG0534	Mate efflux family protein
A4U42_RS01460	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A4U42_RS01465	COG4733	cellulase activity
A4U42_RS01510	COG0534	Mate efflux family protein
A4U42_RS01530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U42_RS01565	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS01565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U42_RS01565	COG3321	synthase
A4U42_RS01565	COG4221	oxidoreductase activity
A4U42_RS01580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4U42_RS01585	COG0322	excinuclease ABC activity
A4U42_RS01590	COG2197	response regulator
A4U42_RS01605	COG1113	amino acid transport
A4U42_RS01620	COG1819	glycosyl
A4U42_RS01630	COG0840	transmembrane signaling receptor activity
A4U42_RS01635	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4U42_RS01640	COG0583	DNA-binding transcription factor activity
A4U42_RS01645	COG0436	Aminotransferase
A4U42_RS01665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4U42_RS01665	COG1648	precorrin-2 dehydrogenase activity
A4U42_RS01670	COG0243	molybdopterin cofactor binding
A4U42_RS01675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4U42_RS01675	COG2146	nitrite reductase [NAD(P)H] activity
A4U42_RS01680	COG1116	anion transmembrane transporter activity
A4U42_RS01690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4U42_RS01695	COG3707	response regulator
A4U42_RS01705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U42_RS01710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U42_RS01720	COG2814	Major facilitator Superfamily
A4U42_RS01725	COG0657	acetylesterase activity
A4U42_RS01730	COG3058	Necessary for formate dehydrogenase activity
A4U42_RS01735	COG2271	Major facilitator Superfamily
A4U42_RS01740	COG2864	formate dehydrogenase
A4U42_RS01745	COG0437	4 iron, 4 sulfur cluster binding
A4U42_RS01750	COG3383	formate dehydrogenase (NAD+) activity
A4U42_RS01750	COG0243	molybdopterin cofactor binding
A4U42_RS01755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4U42_RS01760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4U42_RS01760	COG0519	Catalyzes the synthesis of GMP from XMP
A4U42_RS01770	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A4U42_RS01775	COG0309	Hydrogenase expression formation protein (HypE)
A4U42_RS01780	COG0409	Hydrogenase expression formation protein
A4U42_RS01785	COG0298	carbon dioxide binding
A4U42_RS01790	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A4U42_RS01800	COG1773	rubredoxin
A4U42_RS01805	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4U42_RS01810	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A4U42_RS01815	COG5557	Pfam Polysulphide reductase, NrfD
A4U42_RS01820	COG0437	4 iron, 4 sulfur cluster binding
A4U42_RS01825	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A4U42_RS01830	COG0488	(ABC) transporter
A4U42_RS01835	COG0384	phenazine biosynthesis protein PhzF
A4U42_RS01845	COG1007	ATP synthesis coupled electron transport
A4U42_RS01850	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4U42_RS01855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4U42_RS01860	COG0713	ATP synthesis coupled electron transport
A4U42_RS01865	COG0839	Belongs to the complex I subunit 6 family
A4U42_RS01870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4U42_RS01875	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A4U42_RS01885	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A4U42_RS01895	COG0649	NAD binding
A4U42_RS01895	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4U42_RS01905	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4U42_RS01910	COG0583	DNA-binding transcription factor activity
A4U42_RS01915	COG0436	Aminotransferase
A4U42_RS01920	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A4U42_RS01925	COG0471	metal ion transport
A4U42_RS01925	COG0490	domain, Protein
A4U42_RS01930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4U42_RS01935	COG3013	Belongs to the UPF0304 family
A4U42_RS01940	COG3092	negative regulation of chromosome organization
A4U42_RS01945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4U42_RS01950	COG0857	belongs to the CobB CobQ family
A4U42_RS01950	COG0280	phosphate acetyltransferase
A4U42_RS01955	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4U42_RS01960	COG0622	Phosphoesterase
A4U42_RS01965	COG0625	glutathione transferase activity
A4U42_RS01970	COG1090	epimerase
A4U42_RS01985	COG4215	(ABC) transporter
A4U42_RS01990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U42_RS01995	COG0163	prenyltransferase activity
A4U42_RS02000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4U42_RS02005	COG1286	toxin biosynthetic process
A4U42_RS02010	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A4U42_RS02015	COG0285	dihydrofolate synthase activity
A4U42_RS02020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A4U42_RS02025	COG0586	Pfam SNARE associated Golgi protein
A4U42_RS02035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4U42_RS02040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4U42_RS02050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4U42_RS02055	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A4U42_RS02055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4U42_RS02100	COG3101	peptidyl-lysine hydroxylation
A4U42_RS02105	COG0730	response to heat
A4U42_RS02110	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A4U42_RS02115	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4U42_RS02120	COG2890	protein-(glutamine-N5) methyltransferase activity
A4U42_RS02125	COG2840	Smr protein MutS2
A4U42_RS02130	COG2062	phosphohistidine phosphatase, SixA
A4U42_RS02135	COG1024	Enoyl-CoA hydratase
A4U42_RS02135	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4U42_RS02140	COG0183	Belongs to the thiolase family
A4U42_RS02145	COG3691	Protein conserved in bacteria
A4U42_RS02150	COG2067	long-chain fatty acid transport protein
A4U42_RS02155	COG0579	oxidoreductase
A4U42_RS02175	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A4U42_RS02190	COG4592	Periplasmic binding protein
A4U42_RS02200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U42_RS02205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U42_RS02210	COG1120	ATPase activity
A4U42_RS02235	COG2382	esterase
A4U42_RS02240	COG4774	siderophore transport
A4U42_RS02245	COG1169	isochorismate synthase
A4U42_RS02250	COG1021	2,3-dihydroxybenzoate-AMP ligase
A4U42_RS02255	COG1535	isochorismatase
A4U42_RS02255	COG3433	isochorismatase activity
A4U42_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS02265	COG2050	protein possibly involved in aromatic compounds catabolism
A4U42_RS02270	COG1902	pentaerythritol trinitrate reductase activity
A4U42_RS02280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4U42_RS02330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4U42_RS02335	COG1450	Type ii and iii secretion system protein
A4U42_RS02340	COG3031	protein transport across the cell outer membrane
A4U42_RS02345	COG3266	domain, Protein
A4U42_RS02355	COG0436	Aminotransferase
A4U42_RS02360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4U42_RS02365	COG3264	Mechanosensitive ion channel
A4U42_RS02365	COG1511	domain protein
A4U42_RS02380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4U42_RS02405	COG2850	peptidyl-arginine hydroxylation
A4U42_RS02425	COG0583	DNA-binding transcription factor activity
A4U42_RS02430	COG1126	abc transporter atp-binding protein
A4U42_RS02435	COG0765	amino acid transport
A4U42_RS02450	COG0583	DNA-binding transcription factor activity
A4U42_RS02455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4U42_RS02460	COG1301	dicarboxylic acid transport
A4U42_RS02465	COG0436	Aminotransferase
A4U42_RS02470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4U42_RS02490	COG1263	PTS System
A4U42_RS02490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U42_RS02495	COG1874	Beta-galactosidase
A4U42_RS02505	COG3833	ABC-type maltose transport systems, permease component
A4U42_RS02510	COG1175	transmembrane transport
A4U42_RS02515	COG2182	Extracellular solute-binding protein
A4U42_RS02525	COG1473	amidohydrolase
A4U42_RS02535	COG5297	Belongs to the glycosyl hydrolase family 6
A4U42_RS02545	COG4948	Mandelate Racemase Muconate Lactonizing
A4U42_RS02550	COG1904	glucuronate isomerase
A4U42_RS02555	COG2211	Major facilitator Superfamily
A4U42_RS02560	COG0246	Mannitol dehydrogenase
A4U42_RS02565	COG1802	Transcriptional regulator
A4U42_RS02570	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A4U42_RS02575	COG2986	histidine ammonia-lyase
A4U42_RS02620	COG3290	protein histidine kinase activity
A4U42_RS02625	COG4565	transcriptional regulatory protein
A4U42_RS02630	COG2986	histidine ammonia-lyase
A4U42_RS02660	COG0402	S-adenosylhomocysteine deaminase activity
A4U42_RS02680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4U42_RS02685	COG2501	S4 domain
A4U42_RS02690	COG0215	cysteine-tRNA ligase activity
A4U42_RS02700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4U42_RS02705	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4U42_RS02710	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4U42_RS02715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A4U42_RS02720	COG0814	amino acid
A4U42_RS02725	COG1760	l-serine dehydratase
A4U42_RS02740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4U42_RS02745	COG0581	inorganic phosphate transmembrane transporter activity
A4U42_RS02750	COG0573	inorganic phosphate transmembrane transporter activity
A4U42_RS02755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4U42_RS02765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4U42_RS02770	COG0589	response to stress
A4U42_RS02790	COG0670	Belongs to the BI1 family
A4U42_RS02795	COG2920	part of a sulfur-relay system
A4U42_RS02800	COG1254	Belongs to the acylphosphatase family
A4U42_RS02805	COG3785	DNA binding
A4U42_RS02810	COG1832	CoA-binding protein
A4U42_RS02820	COG1803	Methylglyoxal synthase
A4U42_RS02825	COG0210	DNA helicase
A4U42_RS02830	COG3304	Inner membrane component domain
A4U42_RS02835	COG1289	transmembrane transporter activity
A4U42_RS02840	COG3070	regulator of competence-specific genes
A4U42_RS02845	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
A4U42_RS02850	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A4U42_RS02850	COG2885	chlorophyll binding
A4U42_RS02860	COG0667	Aldo Keto reductase
A4U42_RS02865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4U42_RS02870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U42_RS02875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U42_RS02880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U42_RS02885	COG0477	Major facilitator Superfamily
A4U42_RS02890	COG2205	protein histidine kinase activity
A4U42_RS02895	COG0745	RESPONSE REGULATOR receiver
A4U42_RS02900	COG0435	Glutathione S-transferase
A4U42_RS02905	COG0826	peptidase U32
A4U42_RS02910	COG3223	Belongs to the PsiE family
A4U42_RS02915	COG3622	Belongs to the hyi family
A4U42_RS02920	COG2211	Major facilitator Superfamily
A4U42_RS02930	COG0673	inositol 2-dehydrogenase activity
A4U42_RS02945	COG0351	phosphomethylpyrimidine kinase
A4U42_RS02950	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A4U42_RS02955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4U42_RS02960	COG2814	Major facilitator Superfamily
A4U42_RS02970	COG2192	nodulation
A4U42_RS02980	COG0583	DNA-binding transcription factor activity
A4U42_RS02985	COG2814	Major facilitator Superfamily
A4U42_RS02990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4U42_RS03015	COG1733	regulation of RNA biosynthetic process
A4U42_RS03020	COG0604	alcohol dehydrogenase
A4U42_RS03020	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS03020	COG3321	synthase
A4U42_RS03050	COG1309	transcriptional regulator
A4U42_RS03055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4U42_RS03055	COG0519	Catalyzes the synthesis of GMP from XMP
A4U42_RS03060	COG0517	IMP dehydrogenase activity
A4U42_RS03060	COG0516	GMP reductase activity
A4U42_RS03065	COG1570	exodeoxyribonuclease VII activity
A4U42_RS03085	COG1160	GTP binding
A4U42_RS03090	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4U42_RS03095	COG2976	Protein conserved in bacteria
A4U42_RS03100	COG0124	histidyl-tRNA synthetase
A4U42_RS03105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4U42_RS03110	COG1426	Protein conserved in bacteria
A4U42_RS03120	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4U42_RS03125	COG0105	UTP biosynthetic process
A4U42_RS03130	COG2897	thiosulfate sulfurtransferase activity
A4U42_RS03140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4U42_RS03145	COG2975	iron-sulfur cluster assembly
A4U42_RS03150	COG0633	Ferredoxin
A4U42_RS03155	COG0443	Heat shock 70 kDa protein
A4U42_RS03160	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A4U42_RS03165	COG0316	Belongs to the HesB IscA family
A4U42_RS03170	COG0822	iron-sulfur transferase activity
A4U42_RS03180	COG1959	2 iron, 2 sulfur cluster binding
A4U42_RS03185	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A4U42_RS03190	COG0483	inositol monophosphate 1-phosphatase activity
A4U42_RS03200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U42_RS03205	COG1120	ATPase activity
A4U42_RS03215	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A4U42_RS03220	COG3683	transport system, periplasmic component
A4U42_RS03225	COG2814	Major facilitator Superfamily
A4U42_RS03230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4U42_RS03235	COG1017	nitric oxide dioxygenase activity
A4U42_RS03235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4U42_RS03240	COG3866	Pectate lyase
A4U42_RS03260	COG4677	pectinesterase activity
A4U42_RS03265	COG0347	Belongs to the P(II) protein family
A4U42_RS03270	COG2204	response regulator
A4U42_RS03275	COG3170	Tfp pilus assembly protein FimV
A4U42_RS03280	COG2205	protein histidine kinase activity
A4U42_RS03285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4U42_RS03285	COG0047	phosphoribosylformylglycinamidine synthase activity
A4U42_RS03290	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A4U42_RS03300	COG0560	Phosphoserine phosphatase
A4U42_RS03305	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A4U42_RS03320	COG2274	protein secretion by the type I secretion system
A4U42_RS03335	COG2200	EAL domain
A4U42_RS03340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4U42_RS03345	COG0736	holo-[acyl-carrier-protein] synthase activity
A4U42_RS03350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A4U42_RS03355	COG1381	Involved in DNA repair and RecF pathway recombination
A4U42_RS03360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4U42_RS03365	COG0571	ribonuclease III activity
A4U42_RS03375	COG0481	GTPase activity
A4U42_RS03380	COG3086	response to oxidative stress
A4U42_RS03385	COG3026	antisigma factor binding
A4U42_RS03400	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4U42_RS03405	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A4U42_RS03410	COG0513	Belongs to the DEAD box helicase family
A4U42_RS03415	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A4U42_RS03420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4U42_RS03435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4U42_RS03465	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A4U42_RS03470	COG4208	sulfate ABC transporter
A4U42_RS03475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A4U42_RS03480	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A4U42_RS03485	COG3835	regulator
A4U42_RS03495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A4U42_RS03500	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4U42_RS03505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4U42_RS03525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U42_RS03530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4U42_RS03535	COG1120	ATPase activity
A4U42_RS03540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4U42_RS03545	COG1643	Atp-dependent helicase
A4U42_RS03550	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A4U42_RS03555	COG1489	DNA binding
A4U42_RS03560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4U42_RS03565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4U42_RS03570	COG0617	tRNA 3'-terminal CCA addition
A4U42_RS03575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4U42_RS03580	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A4U42_RS03585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4U42_RS03590	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A4U42_RS03595	COG0842	Transport permease protein
A4U42_RS03600	COG1131	(ABC) transporter
A4U42_RS03605	COG0288	reversible hydration of carbon dioxide
A4U42_RS03610	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A4U42_RS03625	COG3842	ATPase activity
A4U42_RS03645	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A4U42_RS03650	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A4U42_RS03660	COG1780	Probably involved in ribonucleotide reductase function
A4U42_RS03665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4U42_RS03670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4U42_RS03685	COG0328	RNA-DNA hybrid ribonuclease activity
A4U42_RS03690	COG2226	methyltransferase
A4U42_RS03695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4U42_RS03700	COG0741	lytic transglycosylase activity
A4U42_RS03700	COG1388	LysM domain
A4U42_RS03705	COG3021	interspecies interaction between organisms
A4U42_RS03735	COG0542	response to heat
A4U42_RS03740	COG1496	oxidoreductase activity
A4U42_RS03745	COG0564	pseudouridine synthase activity
A4U42_RS03750	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4U42_RS03755	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4U42_RS03760	COG1605	Chorismate mutase
A4U42_RS03760	COG0077	Prephenate dehydratase
A4U42_RS03765	COG1605	Chorismate mutase
A4U42_RS03765	COG0287	Prephenate dehydrogenase
A4U42_RS03770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4U42_RS03785	COG0335	large ribosomal subunit rRNA binding
A4U42_RS03790	COG0336	Belongs to the RNA methyltransferase TrmD family
A4U42_RS03795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4U42_RS03800	COG0228	four-way junction DNA binding
A4U42_RS03805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4U42_RS03810	COG4137	Cytochrome C assembly protein
A4U42_RS03815	COG1854	S-ribosylhomocysteine lyase activity
A4U42_RS03820	COG2918	glutathione biosynthetic process
A4U42_RS03825	COG1238	metal cluster binding
A4U42_RS03830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4U42_RS03855	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A4U42_RS03860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4U42_RS03865	COG2137	regulation of response to DNA damage stimulus
A4U42_RS03870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4U42_RS03885	COG3038	cytochrome b561
A4U42_RS03890	COG1280	lysine exporter protein (LysE YggA)
A4U42_RS03920	COG1879	ABC-type sugar transport system periplasmic component
A4U42_RS03925	COG1129	ABC transporter
A4U42_RS03930	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U42_RS03935	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U42_RS03940	COG0688	phosphatidylethanolamine metabolic process
A4U42_RS03955	COG2207	Transcriptional regulator
A4U42_RS03965	COG0523	cobalamin synthesis protein
A4U42_RS03970	COG2879	small protein
A4U42_RS03975	COG1966	Carbon starvation protein
A4U42_RS03985	COG3275	phosphorelay sensor kinase activity
A4U42_RS04005	COG0601	transmembrane transport
A4U42_RS04010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS04020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4U42_RS04030	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A4U42_RS04055	COG0583	DNA-binding transcription factor activity
A4U42_RS04065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U42_RS04070	COG1696	Membrane protein involved in D-alanine export
A4U42_RS04095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4U42_RS04100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A4U42_RS04110	COG2199	diguanylate cyclase activity
A4U42_RS04120	COG1073	alpha beta
A4U42_RS04125	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A4U42_RS04135	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4U42_RS04140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4U42_RS04145	COG3034	peptidoglycan biosynthetic process
A4U42_RS04150	COG0121	glutamine amidotransferase
A4U42_RS04155	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4U42_RS04160	COG1960	acyl-CoA dehydrogenase activity
A4U42_RS04165	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
A4U42_RS04170	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A4U42_RS04175	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A4U42_RS04180	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
A4U42_RS04185	COG0235	Class ii aldolase
A4U42_RS04190	COG0436	Aminotransferase
A4U42_RS04195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4U42_RS04205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4U42_RS04215	COG0765	amino acid transport
A4U42_RS04260	COG3550	peptidyl-serine autophosphorylation
A4U42_RS04280	COG1953	Uracil, thiamine, allantoin
A4U42_RS04285	COG4175	Glycine betaine
A4U42_RS04290	COG4176	ABC-type proline glycine betaine transport system permease component
A4U42_RS04295	COG2113	Glycine betaine
A4U42_RS04300	COG2814	Major facilitator Superfamily
A4U42_RS04305	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A4U42_RS04315	COG1846	Transcriptional regulator
A4U42_RS04320	COG1566	PFAM secretion protein HlyD family protein
A4U42_RS04325	COG2814	Major facilitator Superfamily
A4U42_RS04330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4U42_RS04335	COG3118	belongs to the thioredoxin family
A4U42_RS04340	COG3148	PFAM DTW domain containing protein
A4U42_RS04345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4U42_RS04345	COG1042	CoA-binding domain protein
A4U42_RS04345	COG0045	succinate-CoA ligase (ADP-forming) activity
A4U42_RS04350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4U42_RS04355	COG5544	Lipoprotein
A4U42_RS04360	COG0477	Major facilitator Superfamily
A4U42_RS04400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4U42_RS04405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4U42_RS04410	COG2011	ABC-type metal ion transport system permease component
A4U42_RS04415	COG1464	Belongs to the NlpA lipoprotein family
A4U42_RS04425	COG1720	tRNA m6t6A37 methyltransferase activity
A4U42_RS04430	COG0442	prolyl-tRNA aminoacylation
A4U42_RS04440	COG1388	LysM domain
A4U42_RS04440	COG4942	peptidase
A4U42_RS04445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4U42_RS04450	COG0585	pseudouridine synthase activity
A4U42_RS04455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4U42_RS04460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4U42_RS04465	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A4U42_RS04475	COG0529	Catalyzes the synthesis of activated sulfate
A4U42_RS04480	COG2895	sulfate adenylyltransferase (ATP) activity
A4U42_RS04490	COG1648	precorrin-2 dehydrogenase activity
A4U42_RS04490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4U42_RS04495	COG0175	sulfate reduction
A4U42_RS04500	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4U42_RS04505	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A4U42_RS04510	COG0720	synthase
A4U42_RS04515	COG0602	queuosine metabolic process
A4U42_RS04520	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A4U42_RS04525	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4U42_RS04535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4U42_RS04545	COG0148	phosphopyruvate hydratase activity
A4U42_RS04550	COG0504	CTP synthase activity
A4U42_RS04555	COG3956	TIGRFAM MazG family protein
A4U42_RS04560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4U42_RS04565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4U42_RS04575	COG1929	Belongs to the glycerate kinase type-1 family
A4U42_RS04580	COG2084	Dehydrogenase
A4U42_RS04590	COG4948	Mandelate Racemase Muconate Lactonizing
A4U42_RS04595	COG4948	Mandelate Racemase Muconate Lactonizing
A4U42_RS04600	COG2271	Major facilitator Superfamily
A4U42_RS04605	COG2721	sulfolactate sulfo-lyase activity
A4U42_RS04610	COG0840	transmembrane signaling receptor activity
A4U42_RS04630	COG3530	Putative quorum-sensing-regulated virulence factor
A4U42_RS04635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4U42_RS04640	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4U42_RS04640	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4U42_RS04645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A4U42_RS04650	COG3025	triphosphatase activity
A4U42_RS04655	COG4991	sh3 domain protein
A4U42_RS04660	COG0617	tRNA 3'-terminal CCA addition
A4U42_RS04665	COG1968	undecaprenyl-diphosphatase activity
A4U42_RS04670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4U42_RS04675	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A4U42_RS04685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A4U42_RS04690	COG2105	PFAM AIG2 family protein
A4U42_RS04700	COG0729	surface antigen
A4U42_RS04705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4U42_RS04710	COG1253	flavin adenine dinucleotide binding
A4U42_RS04720	COG1218	3'(2'),5'-bisphosphate nucleotidase
A4U42_RS04725	COG0737	Belongs to the 5'-nucleotidase family
A4U42_RS04730	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A4U42_RS04740	COG0545	Peptidyl-prolyl cis-trans isomerase
A4U42_RS04745	COG3061	Opacity-associated protein A
A4U42_RS04755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4U42_RS04760	COG1609	Transcriptional regulator
A4U42_RS04765	COG0840	transmembrane signaling receptor activity
A4U42_RS04775	COG2271	Major facilitator Superfamily
A4U42_RS04785	COG0359	binds to the 23S rRNA
A4U42_RS04790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4U42_RS04795	COG2965	DNA replication, synthesis of RNA primer
A4U42_RS04800	COG0360	Binds together with S18 to 16S ribosomal RNA
A4U42_RS04805	COG1073	alpha beta
A4U42_RS04825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4U42_RS04830	COG0557	exoribonuclease II activity
A4U42_RS04835	COG1959	2 iron, 2 sulfur cluster binding
A4U42_RS04850	COG0402	S-adenosylhomocysteine deaminase activity
A4U42_RS04855	COG2805	Type II/IV secretion system protein
A4U42_RS04860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4U42_RS04865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4U42_RS04870	COG0762	integral membrane protein
A4U42_RS04875	COG1872	DUF167
A4U42_RS04880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4U42_RS04885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4U42_RS04895	COG2153	protein acetylation
A4U42_RS04900	COG0477	Major facilitator Superfamily
A4U42_RS04905	COG0204	Acyl-transferase
A4U42_RS04905	COG0318	PFAM AMP-dependent synthetase and ligase
A4U42_RS04910	COG2723	6-phospho-beta-galactosidase activity
A4U42_RS04915	COG2723	6-phospho-beta-galactosidase activity
A4U42_RS04920	COG2190	(PTS) system
A4U42_RS04920	COG1263	PTS System
A4U42_RS04920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U42_RS04925	COG3711	transcriptional antiterminator
A4U42_RS04935	COG1609	Transcriptional regulator
A4U42_RS04945	COG2186	Transcriptional regulator
A4U42_RS04950	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4U42_RS04955	COG2723	6-phospho-beta-galactosidase activity
A4U42_RS04960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4U42_RS04965	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4U42_RS04970	COG1609	Transcriptional regulator
A4U42_RS04980	COG0583	DNA-binding transcription factor activity
A4U42_RS04990	COG3842	ATPase activity
A4U42_RS05000	COG4149	molybdate abc transporter
A4U42_RS05025	COG5642	Protein of unknown function (DUF2384)
A4U42_RS05060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4U42_RS05080	COG1522	sequence-specific DNA binding
A4U42_RS05090	COG1448	Aminotransferase
A4U42_RS05095	COG0840	transmembrane signaling receptor activity
A4U42_RS05105	COG0432	Pfam Uncharacterised protein family UPF0047
A4U42_RS05110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4U42_RS05205	COG1609	Transcriptional regulator
A4U42_RS05210	COG0395	ABC-type sugar transport system, permease component
A4U42_RS05215	COG1175	transmembrane transport
A4U42_RS05220	COG3842	ATPase activity
A4U42_RS05225	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4U42_RS05245	COG2971	BadF BadG BcrA BcrD
A4U42_RS05255	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4U42_RS05260	COG1121	(ABC) transporter
A4U42_RS05265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4U42_RS05270	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4U42_RS05285	COG1349	DNA-binding transcription factor activity
A4U42_RS05290	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4U42_RS05295	COG3395	kinase activity
A4U42_RS05300	COG1454	alcohol dehydrogenase
A4U42_RS05305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4U42_RS05320	COG2731	YhcH YjgK YiaL family protein
A4U42_RS05330	COG0861	Integral membrane protein TerC family
A4U42_RS05335	COG3112	Uncharacterised protein family (UPF0231)
A4U42_RS05350	COG4771	TonB-dependent receptor
A4U42_RS05355	COG4977	sequence-specific DNA binding
A4U42_RS05360	COG2079	MmgE PrpD family protein
A4U42_RS05370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4U42_RS05375	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4U42_RS05380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A4U42_RS05390	COG1113	amino acid transport
A4U42_RS05395	COG3725	Membrane protein required for beta-lactamase induction
A4U42_RS05400	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4U42_RS05405	COG3248	Nucleoside-binding outer membrane protein
A4U42_RS05415	COG4969	Belongs to the N-Me-Phe pilin family
A4U42_RS05420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4U42_RS05425	COG1459	type II secretion system
A4U42_RS05435	COG0237	dephospho-CoA kinase activity
A4U42_RS05440	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A4U42_RS05450	COG0494	nUDIX hydrolase
A4U42_RS05455	COG0653	protein targeting
A4U42_RS05470	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A4U42_RS05475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A4U42_RS05480	COG0849	cell division
A4U42_RS05485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A4U42_RS05490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4U42_RS05495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4U42_RS05500	COG0772	Belongs to the SEDS family
A4U42_RS05505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4U42_RS05510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4U42_RS05515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4U42_RS05520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4U42_RS05525	COG0768	penicillin binding
A4U42_RS05530	COG3116	cell division
A4U42_RS05535	COG0275	rRNA processing
A4U42_RS05540	COG2001	Belongs to the MraZ family
A4U42_RS05560	COG0028	Belongs to the TPP enzyme family
A4U42_RS05565	COG1022	Amp-dependent synthetase and ligase
A4U42_RS05570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4U42_RS05575	COG0473	3-isopropylmalate dehydrogenase activity
A4U42_RS05580	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4U42_RS05585	COG0066	3-isopropylmalate dehydratase activity
A4U42_RS05595	COG3033	Beta-eliminating lyase
A4U42_RS05605	COG4533	DNA binding
A4U42_RS05615	COG1178	ABC-type Fe3 transport system permease component
A4U42_RS05620	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A4U42_RS05625	COG0028	Belongs to the TPP enzyme family
A4U42_RS05630	COG0440	acetolactate synthase activity
A4U42_RS05635	COG0586	Pfam SNARE associated Golgi protein
A4U42_RS05665	COG0411	ABC transporter
A4U42_RS05685	COG0417	DNA replication proofreading
A4U42_RS05690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4U42_RS05695	COG0564	pseudouridine synthase activity
A4U42_RS05700	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A4U42_RS05705	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A4U42_RS05710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4U42_RS05715	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4U42_RS05720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4U42_RS05725	COG2967	ApaG domain
A4U42_RS05730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4U42_RS05735	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4U42_RS05740	COG3610	response to peptide
A4U42_RS05745	COG2966	Psort location CytoplasmicMembrane, score
A4U42_RS05750	COG1280	lysine exporter protein (LysE YggA)
A4U42_RS05755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4U42_RS05760	COG0505	Belongs to the CarA family
A4U42_RS05775	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4U42_RS05780	COG1047	Peptidyl-prolyl cis-trans
A4U42_RS05785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A4U42_RS05790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4U42_RS05795	COG0196	riboflavin kinase activity
A4U42_RS05800	COG0268	Binds directly to 16S ribosomal RNA
A4U42_RS05805	COG0583	DNA-binding transcription factor activity
A4U42_RS05810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4U42_RS05815	COG0484	heat shock protein binding
A4U42_RS05825	COG1584	GPR1 FUN34 yaaH family protein
A4U42_RS05835	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4U42_RS05840	COG3706	GGDEF domain
A4U42_RS05845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4U42_RS05850	COG3022	response to hydroperoxide
A4U42_RS05860	COG0083	homoserine kinase activity
A4U42_RS05870	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A4U42_RS05875	COG0745	RESPONSE REGULATOR receiver
A4U42_RS05880	COG3045	CreA protein
A4U42_RS05885	COG2207	Transcriptional regulator
A4U42_RS05885	COG3708	Transcriptional regulator
A4U42_RS05890	COG0406	alpha-ribazole phosphatase activity
A4U42_RS05895	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A4U42_RS05900	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
A4U42_RS05910	COG0488	(ABC) transporter
A4U42_RS05915	COG0840	transmembrane signaling receptor activity
A4U42_RS05925	COG0604	alcohol dehydrogenase
A4U42_RS05930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4U42_RS05935	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A4U42_RS05940	COG0583	DNA-binding transcription factor activity
A4U42_RS05945	COG2968	Membrane
A4U42_RS05950	COG1414	Transcriptional regulator
A4U42_RS05955	COG0668	transmembrane transport
A4U42_RS05965	COG0126	phosphoglycerate kinase activity
A4U42_RS05970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4U42_RS05975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4U42_RS05980	COG0738	Major facilitator superfamily
A4U42_RS05985	COG1166	arginine decarboxylase activity
A4U42_RS05995	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4U42_RS06000	COG3091	SprT-like family
A4U42_RS06005	COG2356	endonuclease I
A4U42_RS06010	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4U42_RS06015	COG0189	ligase activity
A4U42_RS06020	COG1678	Uncharacterized ACR, COG1678
A4U42_RS06025	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A4U42_RS06030	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A4U42_RS06035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4U42_RS06040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4U42_RS06045	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A4U42_RS06050	COG0330	HflC and HflK could
A4U42_RS06055	COG0330	HflC and HflK could
A4U42_RS06060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4U42_RS06065	COG1923	regulation of RNA biosynthetic process
A4U42_RS06070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4U42_RS06075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A4U42_RS06085	COG0802	atpase or kinase
A4U42_RS06090	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4U42_RS06090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4U42_RS06100	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4U42_RS06120	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A4U42_RS06150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4U42_RS06165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U42_RS06170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U42_RS06190	COG0765	amino acid transport
A4U42_RS06195	COG1126	abc transporter atp-binding protein
A4U42_RS06205	COG1764	response to oxidative stress
A4U42_RS06210	COG1846	Transcriptional regulator
A4U42_RS06215	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A4U42_RS06220	COG1473	amidohydrolase
A4U42_RS06230	COG0583	DNA-binding transcription factor activity
A4U42_RS06235	COG0840	transmembrane signaling receptor activity
A4U42_RS06250	COG3604	Transcriptional regulator
A4U42_RS06255	COG2205	protein histidine kinase activity
A4U42_RS06270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4U42_RS06325	COG0840	transmembrane signaling receptor activity
A4U42_RS06370	COG2977	Belongs to the P-Pant transferase superfamily
A4U42_RS06385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4U42_RS06385	COG2070	2-Nitropropane dioxygenase
A4U42_RS06395	COG3321	synthase
A4U42_RS06395	COG3321	synthase
A4U42_RS06395	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS06395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4U42_RS06395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4U42_RS06395	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS06395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4U42_RS06395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4U42_RS06395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U42_RS06395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U42_RS06400	COG3321	synthase
A4U42_RS06400	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS06400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U42_RS06400	COG4221	oxidoreductase activity
A4U42_RS06415	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS06415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U42_RS06415	COG0300	oxidoreductase activity
A4U42_RS06415	COG3321	synthase
A4U42_RS06415	COG0318	PFAM AMP-dependent synthetase and ligase
A4U42_RS06420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U42_RS06420	COG4221	oxidoreductase activity
A4U42_RS06420	COG3321	synthase
A4U42_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS06425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U42_RS06430	COG4221	oxidoreductase activity
A4U42_RS06430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4U42_RS06430	COG3321	synthase
A4U42_RS06430	COG0300	oxidoreductase activity
A4U42_RS06435	COG2072	flavoprotein involved in K transport
A4U42_RS06440	COG4221	oxidoreductase activity
A4U42_RS06440	COG3321	synthase
A4U42_RS06440	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS06440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U42_RS06445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4U42_RS06450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4U42_RS06455	COG3425	synthase
A4U42_RS06460	COG1024	Enoyl-CoA hydratase
A4U42_RS06465	COG1024	Enoyl-CoA hydratase
A4U42_RS06485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A4U42_RS06490	COG1162	GTPase activity
A4U42_RS06495	COG0688	phosphatidylethanolamine metabolic process
A4U42_RS06500	COG1511	domain protein
A4U42_RS06500	COG3264	Mechanosensitive ion channel
A4U42_RS06505	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A4U42_RS06510	COG1053	succinate dehydrogenase
A4U42_RS06515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4U42_RS06520	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A4U42_RS06525	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A4U42_RS06535	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4U42_RS06540	COG1509	lysine 2,3-aminomutase activity
A4U42_RS06550	COG4124	Belongs to the glycosyl hydrolase 26 family
A4U42_RS06555	COG0166	Belongs to the GPI family
A4U42_RS06560	COG0527	aspartate kinase activity
A4U42_RS06570	COG1283	sodium-dependent phosphate transmembrane transporter activity
A4U42_RS06575	COG0471	metal ion transport
A4U42_RS06580	COG1410	methionine synthase
A4U42_RS06580	COG0646	methionine synthase
A4U42_RS06585	COG1414	Transcriptional regulator
A4U42_RS06590	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A4U42_RS06600	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A4U42_RS06605	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A4U42_RS06635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A4U42_RS06645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4U42_RS06650	COG0009	L-threonylcarbamoyladenylate synthase
A4U42_RS06660	COG2922	Belongs to the Smg family
A4U42_RS06665	COG0758	DNA mediated transformation
A4U42_RS06670	COG0242	peptide deformylase activity
A4U42_RS06675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4U42_RS06680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4U42_RS06680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4U42_RS06690	COG1970	mechanosensitive ion channel activity
A4U42_RS06695	COG3036	rescue of stalled ribosome
A4U42_RS06705	COG0203	ribosomal protein L17
A4U42_RS06715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4U42_RS06725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4U42_RS06735	COG0201	protein transport
A4U42_RS06740	COG0200	Binds to the 23S rRNA
A4U42_RS06745	COG1841	ribosomal large subunit assembly
A4U42_RS06750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4U42_RS06760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4U42_RS06770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4U42_RS06775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4U42_RS06790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4U42_RS06795	COG0255	Belongs to the universal ribosomal protein uL29 family
A4U42_RS06800	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4U42_RS06810	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4U42_RS06815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4U42_RS06820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4U42_RS06825	COG0089	rRNA binding
A4U42_RS06830	COG0088	Forms part of the polypeptide exit tunnel
A4U42_RS06835	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4U42_RS06840	COG0051	transcription antitermination factor activity, RNA binding
A4U42_RS06855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4U42_RS06860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4U42_RS06865	COG0049	tRNA binding
A4U42_RS06870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4U42_RS06875	COG2168	tRNA wobble position uridine thiolation
A4U42_RS06880	COG2923	Belongs to the DsrF TusC family
A4U42_RS06885	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A4U42_RS06890	COG2964	Protein conserved in bacteria
A4U42_RS06895	COG2194	sulfuric ester hydrolase activity
A4U42_RS06900	COG0745	RESPONSE REGULATOR receiver
A4U42_RS06905	COG0642	Histidine kinase
A4U42_RS06910	COG1126	abc transporter atp-binding protein
A4U42_RS06915	COG0765	amino acid transport
A4U42_RS06925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4U42_RS06940	COG0545	Peptidyl-prolyl cis-trans isomerase
A4U42_RS06945	COG2900	Belongs to the SlyX family
A4U42_RS06955	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A4U42_RS06970	COG2140	Oxalate decarboxylase
A4U42_RS06975	COG1047	Peptidyl-prolyl cis-trans
A4U42_RS06980	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A4U42_RS06985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4U42_RS06985	COG0475	glutathione-regulated potassium exporter activity
A4U42_RS06990	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4U42_RS06995	COG0488	(ABC) transporter
A4U42_RS07005	COG0429	hydrolase of the alpha beta-hydrolase fold
A4U42_RS07015	COG3954	Phosphoribulokinase
A4U42_RS07020	COG1765	OsmC-like protein
A4U42_RS07040	COG4753	response regulator
A4U42_RS07040	COG2207	Transcriptional regulator
A4U42_RS07045	COG1404	Belongs to the peptidase S8 family
A4U42_RS07050	COG3179	chitinase
A4U42_RS07090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4U42_RS07095	COG4948	Mandelate Racemase Muconate Lactonizing
A4U42_RS07105	COG0546	phosphoglycolate phosphatase activity
A4U42_RS07110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4U42_RS07125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4U42_RS07130	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4U42_RS07135	COG4796	Type ii and iii secretion system protein
A4U42_RS07160	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A4U42_RS07165	COG0494	nUDIX hydrolase
A4U42_RS07175	COG1011	Hydrolase
A4U42_RS07180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4U42_RS07185	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A4U42_RS07190	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A4U42_RS07205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4U42_RS07215	COG2183	response to ionizing radiation
A4U42_RS07225	COG2267	carboxylic ester hydrolase activity
A4U42_RS07235	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A4U42_RS07235	COG0316	Belongs to the HesB IscA family
A4U42_RS07240	COG1640	4-alpha-glucanotransferase
A4U42_RS07245	COG0058	SHG alpha-glucan phosphorylase activity
A4U42_RS07250	COG1349	DNA-binding transcription factor activity
A4U42_RS07255	COG0705	Rhomboid family
A4U42_RS07260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U42_RS07270	COG2731	YhcH YjgK YiaL family protein
A4U42_RS07275	COG2271	Major facilitator Superfamily
A4U42_RS07285	COG5001	Diguanylate cyclase
A4U42_RS07295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4U42_RS07300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4U42_RS07305	COG0058	SHG alpha-glucan phosphorylase activity
A4U42_RS07310	COG0297	glycogen (starch) synthase activity
A4U42_RS07315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4U42_RS07330	COG3275	phosphorelay sensor kinase activity
A4U42_RS07335	COG1278	Cold shock
A4U42_RS07345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4U42_RS07350	COG2095	MarC family integral membrane protein
A4U42_RS07355	COG2610	gluconate transmembrane transporter activity
A4U42_RS07360	COG3265	gluconokinase activity
A4U42_RS07365	COG1609	Transcriptional regulator
A4U42_RS07375	COG1741	Belongs to the pirin family
A4U42_RS07380	COG0247	lactate metabolic process
A4U42_RS07385	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A4U42_RS07390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4U42_RS07395	COG2271	Major facilitator Superfamily
A4U42_RS07400	COG0584	glycerophosphoryl diester phosphodiesterase
A4U42_RS07405	COG0561	phosphatase activity
A4U42_RS07410	COG2267	carboxylic ester hydrolase activity
A4U42_RS07415	COG1280	lysine exporter protein (LysE YggA)
A4U42_RS07420	COG1280	lysine exporter protein (LysE YggA)
A4U42_RS07425	COG0514	ATP-dependent DNA helicase (RecQ)
A4U42_RS07435	COG2050	protein possibly involved in aromatic compounds catabolism
A4U42_RS07445	COG3180	Ammonia monooxygenase
A4U42_RS07450	COG0598	Magnesium transport protein CorA
A4U42_RS07455	COG0210	DNA helicase
A4U42_RS07460	COG1011	Hydrolase
A4U42_RS07475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4U42_RS07495	COG0181	hydroxymethylbilane synthase activity
A4U42_RS07500	COG1587	Uroporphyrinogen-III synthase
A4U42_RS07505	COG2959	enzyme of heme biosynthesis
A4U42_RS07510	COG3071	HemY protein
A4U42_RS07515	COG1473	amidohydrolase
A4U42_RS07520	COG1126	abc transporter atp-binding protein
A4U42_RS07525	COG0765	amino acid transport
A4U42_RS07530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U42_RS07535	COG0456	acetyltransferase
A4U42_RS07540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4U42_RS07550	COG0371	Dehydrogenase
A4U42_RS07555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U42_RS07585	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A4U42_RS07595	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4U42_RS07600	COG2244	polysaccharide biosynthetic process
A4U42_RS07605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4U42_RS07615	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A4U42_RS07620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A4U42_RS07625	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A4U42_RS07630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4U42_RS07635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4U42_RS07640	COG3118	belongs to the thioredoxin family
A4U42_RS07645	COG0513	Belongs to the DEAD box helicase family
A4U42_RS07650	COG0248	Ppx GppA phosphatase
A4U42_RS07680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4U42_RS07685	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A4U42_RS07685	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A4U42_RS07685	COG0506	proline dehydrogenase activity
A4U42_RS07690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4U42_RS07700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4U42_RS07720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4U42_RS07730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4U42_RS07735	COG3978	acetolactate synthase activity
A4U42_RS07745	COG2814	Major facilitator Superfamily
A4U42_RS07755	COG3085	chromosome segregation
A4U42_RS07760	COG0583	DNA-binding transcription factor activity
A4U42_RS07800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4U42_RS07810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4U42_RS07825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4U42_RS07835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4U42_RS07835	COG0678	peroxiredoxin activity
A4U42_RS07845	COG0460	homoserine dehydrogenase
A4U42_RS07845	COG0527	aspartate kinase activity
A4U42_RS07850	COG0626	cystathionine gamma-synthase activity
A4U42_RS07855	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A4U42_RS07865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4U42_RS07870	COG1609	Transcriptional regulator
A4U42_RS07875	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4U42_RS07880	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A4U42_RS07885	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A4U42_RS07890	COG1575	Belongs to the MenA family. Type 1 subfamily
A4U42_RS07895	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4U42_RS07900	COG3074	FtsZ-dependent cytokinesis
A4U42_RS07905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4U42_RS07915	COG1494	fructose-1,6-bisphosphatase
A4U42_RS07925	COG3152	Membrane
A4U42_RS07935	COG0149	triose-phosphate isomerase activity
A4U42_RS07945	COG2957	Belongs to the agmatine deiminase family
A4U42_RS07950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4U42_RS07955	COG0205	6-phosphofructokinase activity
A4U42_RS07960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A4U42_RS07975	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4U42_RS07990	COG2963	transposase activity
A4U42_RS07995	COG2801	Transposase and inactivated derivatives
A4U42_RS08005	COG3678	ATP-independent chaperone mediated protein folding
A4U42_RS08010	COG0745	RESPONSE REGULATOR receiver
A4U42_RS08015	COG2205	protein histidine kinase activity
A4U42_RS08030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4U42_RS08035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4U42_RS08045	COG0679	Auxin Efflux Carrier
A4U42_RS08050	COG0584	glycerophosphoryl diester phosphodiesterase
A4U42_RS08055	COG3842	ATPase activity
A4U42_RS08060	COG0395	ABC-type sugar transport system, permease component
A4U42_RS08065	COG1175	transmembrane transport
A4U42_RS08070	COG1653	transport
A4U42_RS08080	COG0840	transmembrane signaling receptor activity
A4U42_RS08085	COG0840	transmembrane signaling receptor activity
A4U42_RS08090	COG0840	transmembrane signaling receptor activity
A4U42_RS08100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4U42_RS08110	COG0411	ABC transporter
A4U42_RS08115	COG4177	L-phenylalanine transmembrane transporter activity
A4U42_RS08120	COG0559	Belongs to the binding-protein-dependent transport system permease family
A4U42_RS08125	COG0683	leucine binding
A4U42_RS08130	COG0456	acetyltransferase
A4U42_RS08140	COG2177	Part of the ABC transporter FtsEX involved in
A4U42_RS08145	COG2884	Cell division ATP-binding protein ftsE
A4U42_RS08150	COG0552	protein localization to endoplasmic reticulum
A4U42_RS08150	COG0552	protein localization to endoplasmic reticulum
A4U42_RS08155	COG3493	citrate carrier protein
A4U42_RS08160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4U42_RS08170	COG0742	ribosomal rna small subunit methyltransferase
A4U42_RS08175	COG3776	membrane
A4U42_RS08185	COG3714	YhhN family
A4U42_RS08190	COG0425	Belongs to the sulfur carrier protein TusA family
A4U42_RS08195	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A4U42_RS08205	COG0477	Major facilitator Superfamily
A4U42_RS08210	COG1295	ribonuclease BN
A4U42_RS08215	COG1942	4-Oxalocrotonate Tautomerase
A4U42_RS08220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U42_RS08230	COG1301	dicarboxylic acid transport
A4U42_RS08235	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A4U42_RS08245	COG0457	Tetratricopeptide repeat
A4U42_RS08255	COG1215	transferase activity, transferring glycosyl groups
A4U42_RS08260	COG0489	protein tyrosine kinase activity
A4U42_RS08275	COG2378	regulation of single-species biofilm formation
A4U42_RS08285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4U42_RS08305	COG4608	Belongs to the ABC transporter superfamily
A4U42_RS08310	COG0444	Belongs to the ABC transporter superfamily
A4U42_RS08315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS08320	COG0601	transmembrane transport
A4U42_RS08325	COG0747	negative chemotaxis
A4U42_RS08330	COG3493	citrate carrier protein
A4U42_RS08335	COG4565	transcriptional regulatory protein
A4U42_RS08340	COG3290	protein histidine kinase activity
A4U42_RS08345	COG0471	metal ion transport
A4U42_RS08350	COG0071	Belongs to the small heat shock protein (HSP20) family
A4U42_RS08355	COG0071	Belongs to the small heat shock protein (HSP20) family
A4U42_RS08360	COG5645	(Lipo)protein
A4U42_RS08370	COG0477	Major facilitator Superfamily
A4U42_RS08380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4U42_RS08395	COG2085	NADP oxidoreductase coenzyme F420-dependent
A4U42_RS08400	COG1733	regulation of RNA biosynthetic process
A4U42_RS08405	COG0823	Involved in the tonB-independent uptake of proteins
A4U42_RS08425	COG0561	phosphatase activity
A4U42_RS08435	COG0589	response to stress
A4U42_RS08445	COG0306	phosphate transporter
A4U42_RS08450	COG2081	HI0933 family
A4U42_RS08475	COG3842	ATPase activity
A4U42_RS08480	COG0395	ABC-type sugar transport system, permease component
A4U42_RS08530	COG1653	transport
A4U42_RS08540	COG1175	transmembrane transport
A4U42_RS08550	COG2814	Major facilitator Superfamily
A4U42_RS08555	COG0583	DNA-binding transcription factor activity
A4U42_RS08570	COG4221	oxidoreductase activity
A4U42_RS08585	COG2194	sulfuric ester hydrolase activity
A4U42_RS08590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4U42_RS08595	COG0194	GDP metabolic process
A4U42_RS08605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4U42_RS08610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4U42_RS08615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4U42_RS08620	COG2233	PERMEase
A4U42_RS08625	COG2982	Protein involved in outer membrane biogenesis
A4U42_RS08630	COG0456	acetyltransferase
A4U42_RS08635	COG1490	D-aminoacyl-tRNA deacylase activity
A4U42_RS08640	COG1011	Hydrolase
A4U42_RS08645	COG1217	gtp-binding protein TYPA
A4U42_RS08655	COG3852	Histidine kinase
A4U42_RS08670	COG3078	GTPase activator activity
A4U42_RS08675	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A4U42_RS08685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4U42_RS08690	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A4U42_RS08695	COG3084	Protein conserved in bacteria
A4U42_RS08705	COG1763	Mo-molybdopterin cofactor biosynthetic process
A4U42_RS08735	COG1609	Transcriptional regulator
A4U42_RS08740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U42_RS08745	COG1879	ABC-type sugar transport system periplasmic component
A4U42_RS08750	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U42_RS08755	COG1129	ABC transporter
A4U42_RS08760	COG1869	D-ribose catabolic process
A4U42_RS08765	COG3158	transport of potassium into the cell
A4U42_RS08770	COG0714	Associated with various cellular activities
A4U42_RS08775	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A4U42_RS08780	COG1522	sequence-specific DNA binding
A4U42_RS08785	COG0716	FMN binding
A4U42_RS08790	COG0445	tRNA wobble uridine modification
A4U42_RS08795	COG0357	Ribosomal RNA small subunit methyltransferase G
A4U42_RS08800	COG3312	ion transport
A4U42_RS08805	COG0356	it plays a direct role in the translocation of protons across the membrane
A4U42_RS08815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4U42_RS08820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4U42_RS08825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4U42_RS08830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4U42_RS08835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4U42_RS08840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4U42_RS08850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4U42_RS08855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4U42_RS08880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4U42_RS08885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4U42_RS08940	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS08950	COG3706	GGDEF domain
A4U42_RS08955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4U42_RS08960	COG0573	inorganic phosphate transmembrane transporter activity
A4U42_RS08965	COG0581	inorganic phosphate transmembrane transporter activity
A4U42_RS08970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4U42_RS08980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U42_RS08990	COG0765	amino acid transport
A4U42_RS08995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4U42_RS09000	COG2252	PERMEase
A4U42_RS09005	COG2091	lysine biosynthetic process via aminoadipic acid
A4U42_RS09010	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4U42_RS09015	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4U42_RS09015	COG0493	'glutamate synthase
A4U42_RS09020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4U42_RS09025	COG0463	Glycosyl transferase, family 2
A4U42_RS09035	COG0726	polysaccharide deacetylase
A4U42_RS09040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4U42_RS09045	COG2076	Multidrug Resistance protein
A4U42_RS09050	COG2076	Multidrug Resistance protein
A4U42_RS09060	COG2910	NAD(P)H-binding
A4U42_RS09065	COG1733	regulation of RNA biosynthetic process
A4U42_RS09075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A4U42_RS09085	COG1396	sequence-specific DNA binding
A4U42_RS09090	COG3550	peptidyl-serine autophosphorylation
A4U42_RS09095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4U42_RS09100	COG0706	membrane insertase activity
A4U42_RS09105	COG0594	ribonuclease P activity
A4U42_RS09110	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4U42_RS09115	COG0592	DNA-directed DNA polymerase activity
A4U42_RS09120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4U42_RS09135	COG0742	ribosomal rna small subunit methyltransferase
A4U42_RS09140	COG0339	signal peptide processing
A4U42_RS09150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A4U42_RS09155	COG1234	tRNA 3'-trailer cleavage
A4U42_RS09160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4U42_RS09165	COG0471	metal ion transport
A4U42_RS09170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4U42_RS09175	COG2188	Transcriptional regulator
A4U42_RS09180	COG1696	Membrane protein involved in D-alanine export
A4U42_RS09200	COG1522	sequence-specific DNA binding
A4U42_RS09205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4U42_RS09210	COG1509	lysine 2,3-aminomutase activity
A4U42_RS09230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4U42_RS09235	COG4191	Histidine kinase
A4U42_RS09255	COG0583	DNA-binding transcription factor activity
A4U42_RS09275	COG0837	glucose binding
A4U42_RS09285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U42_RS09290	COG4172	Belongs to the ABC transporter superfamily
A4U42_RS09295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS09300	COG0601	transmembrane transport
A4U42_RS09305	COG0747	negative chemotaxis
A4U42_RS09315	COG3977	Valine--pyruvate aminotransferase
A4U42_RS09325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4U42_RS09330	COG0456	acetyltransferase
A4U42_RS09335	COG2818	Glycosylase
A4U42_RS09345	COG0751	glycine-tRNA ligase activity
A4U42_RS09350	COG3842	ATPase activity
A4U42_RS09355	COG1940	carbohydrate kinase activity
A4U42_RS09360	COG1940	carbohydrate kinase activity
A4U42_RS09375	COG1175	transmembrane transport
A4U42_RS09380	COG0395	ABC-type sugar transport system, permease component
A4U42_RS09400	COG3842	ATPase activity
A4U42_RS09420	COG2213	PTS system mannitol-specific
A4U42_RS09420	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U42_RS09425	COG0246	Mannitol dehydrogenase
A4U42_RS09430	COG3722	fumarate hydratase activity
A4U42_RS09435	COG0840	transmembrane signaling receptor activity
A4U42_RS09440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A4U42_RS09445	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A4U42_RS09450	COG1012	belongs to the aldehyde dehydrogenase family
A4U42_RS09455	COG1070	Carbohydrate kinase
A4U42_RS09460	COG2115	Belongs to the xylose isomerase family
A4U42_RS09465	COG4213	ABC transporter substrate-binding protein
A4U42_RS09470	COG1129	ABC transporter
A4U42_RS09475	COG4214	carbohydrate transport
A4U42_RS09480	COG1609	Transcriptional regulator
A4U42_RS09480	COG2207	Transcriptional regulator
A4U42_RS09505	COG0137	argininosuccinate synthase activity
A4U42_RS09510	COG1846	Transcriptional regulator
A4U42_RS09515	COG0697	spore germination
A4U42_RS09520	COG2313	pseudouridylate synthase activity
A4U42_RS09525	COG0546	phosphoglycolate phosphatase activity
A4U42_RS09530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U42_RS09560	COG1917	Cupin 2, conserved barrel domain protein
A4U42_RS09560	COG2207	Transcriptional regulator
A4U42_RS09565	COG1136	(ABC) transporter
A4U42_RS09565	COG0577	efflux transmembrane transporter activity
A4U42_RS09570	COG0577	efflux transmembrane transporter activity
A4U42_RS09570	COG1136	(ABC) transporter
A4U42_RS09610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4U42_RS09630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U42_RS09645	COG0318	PFAM AMP-dependent synthetase and ligase
A4U42_RS09665	COG2771	luxR family
A4U42_RS09670	COG3916	Acyl-homoserine-lactone synthase
A4U42_RS09725	COG3423	Transcriptional regulator
A4U42_RS09735	COG1561	YicC-like family, N-terminal region
A4U42_RS09740	COG0583	DNA-binding transcription factor activity
A4U42_RS09750	COG0747	negative chemotaxis
A4U42_RS09755	COG0601	transmembrane transport
A4U42_RS09760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS09765	COG0444	Belongs to the ABC transporter superfamily
A4U42_RS09770	COG4608	Belongs to the ABC transporter superfamily
A4U42_RS09800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS09805	COG0601	transmembrane transport
A4U42_RS09810	COG0747	negative chemotaxis
A4U42_RS09815	COG4172	Belongs to the ABC transporter superfamily
A4U42_RS09820	COG4948	Mandelate Racemase Muconate Lactonizing
A4U42_RS09835	COG2149	membrane
A4U42_RS09840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A4U42_RS09845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4U42_RS09850	COG1309	transcriptional regulator
A4U42_RS09855	COG0756	dUTP diphosphatase activity
A4U42_RS09860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4U42_RS09865	COG2003	Belongs to the UPF0758 family
A4U42_RS09880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4U42_RS09885	COG1216	Glycosyl transferase, family 2
A4U42_RS09890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4U42_RS09900	COG1519	Transferase
A4U42_RS09905	COG0438	transferase activity, transferring glycosyl groups
A4U42_RS09925	COG0859	PFAM glycosyl transferase family 9
A4U42_RS09935	COG0859	PFAM glycosyl transferase family 9
A4U42_RS09940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4U42_RS09945	COG0156	8-amino-7-oxononanoate synthase activity
A4U42_RS09950	COG1063	alcohol dehydrogenase
A4U42_RS09955	COG2861	carbohydrate metabolic process
A4U42_RS09960	COG4942	peptidase
A4U42_RS09965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4U42_RS09970	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A4U42_RS09975	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4U42_RS09980	COG1045	serine acetyltransferase
A4U42_RS09995	COG0583	DNA-binding transcription factor activity
A4U42_RS10000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4U42_RS10005	COG0412	Dienelactone hydrolase
A4U42_RS10010	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A4U42_RS10030	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A4U42_RS10035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4U42_RS10040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4U42_RS10045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4U42_RS10050	COG0165	Argininosuccinate lyase
A4U42_RS10055	COG1322	Protein conserved in bacteria
A4U42_RS10060	COG2226	methyltransferase
A4U42_RS10065	COG3165	ubiquinone biosynthetic process from chorismate
A4U42_RS10070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A4U42_RS10085	COG0805	protein transport
A4U42_RS10090	COG0084	hydrolase, TatD family'
A4U42_RS10105	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A4U42_RS10135	COG0183	Belongs to the thiolase family
A4U42_RS10140	COG1024	Enoyl-CoA hydratase
A4U42_RS10140	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4U42_RS10145	COG0006	proline dipeptidase activity
A4U42_RS10150	COG1739	Uncharacterized protein family UPF0029
A4U42_RS10155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4U42_RS10195	COG1072	(Pantothenic acid kinase))
A4U42_RS10230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4U42_RS10240	COG0250	Participates in transcription elongation, termination and antitermination
A4U42_RS10245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4U42_RS10260	COG0222	ribosome binding
A4U42_RS10270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4U42_RS10285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4U42_RS10290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A4U42_RS10295	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
A4U42_RS10315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4U42_RS10320	COG2022	thiamine diphosphate biosynthetic process
A4U42_RS10325	COG2104	thiamine diphosphate biosynthetic process
A4U42_RS10330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4U42_RS10335	COG0352	thiamine-phosphate diphosphorylase activity
A4U42_RS10340	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A4U42_RS10345	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A4U42_RS10350	COG2816	NAD+ diphosphatase activity
A4U42_RS10355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A4U42_RS10360	COG1515	deoxyribonuclease V activity
A4U42_RS10380	COG0151	Belongs to the GarS family
A4U42_RS10385	COG0138	bifunctional purine biosynthesis protein purh
A4U42_RS10415	COG1126	abc transporter atp-binding protein
A4U42_RS10420	COG0765	amino acid transport
A4U42_RS10425	COG4597	amino acid ABC transporter
A4U42_RS10430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U42_RS10435	COG0504	CTP synthase activity
A4U42_RS10440	COG0765	amino acid transport
A4U42_RS10445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U42_RS10455	COG4221	oxidoreductase activity
A4U42_RS10470	COG4221	oxidoreductase activity
A4U42_RS10475	COG1064	alcohol dehydrogenase
A4U42_RS10480	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A4U42_RS10490	COG2264	protein methyltransferase activity
A4U42_RS10495	COG4145	pantothenate transmembrane transporter activity
A4U42_RS10500	COG3924	membrane
A4U42_RS10505	COG0439	Biotin carboxylase
A4U42_RS10510	COG0511	ligase activity, forming carbon-carbon bonds
A4U42_RS10515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4U42_RS10520	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A4U42_RS10525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A4U42_RS10530	COG0604	alcohol dehydrogenase
A4U42_RS10535	COG2200	EAL domain
A4U42_RS10535	COG2199	diguanylate cyclase activity
A4U42_RS10540	COG1077	Cell shape determining protein MreB Mrl
A4U42_RS10545	COG1792	Involved in formation and maintenance of cell shape
A4U42_RS10550	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A4U42_RS10555	COG0424	maF-like protein
A4U42_RS10565	COG3164	Protein of unknown function
A4U42_RS10570	COG0312	modulator of DNA gyrase
A4U42_RS10575	COG0583	DNA-binding transcription factor activity
A4U42_RS10585	COG1566	PFAM secretion protein HlyD family protein
A4U42_RS10590	COG1289	transmembrane transporter activity
A4U42_RS10600	COG1280	lysine exporter protein (LysE YggA)
A4U42_RS10605	COG3028	Belongs to the UPF0307 family
A4U42_RS10610	COG0312	modulator of DNA gyrase
A4U42_RS10615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4U42_RS10620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U42_RS10625	COG1660	Displays ATPase and GTPase activities
A4U42_RS10640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A4U42_RS10645	COG1137	ATPase activity
A4U42_RS10650	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A4U42_RS10655	COG3117	lipopolysaccharide transmembrane transporter activity
A4U42_RS10660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A4U42_RS10665	COG0517	IMP dehydrogenase activity
A4U42_RS10665	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A4U42_RS10670	COG0530	calcium, potassium:sodium antiporter activity
A4U42_RS10675	COG1127	ABC transporter
A4U42_RS10680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4U42_RS10685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4U42_RS10690	COG2854	intermembrane phospholipid transfer
A4U42_RS10695	COG3113	response to antibiotic
A4U42_RS10700	COG5007	Belongs to the BolA IbaG family
A4U42_RS10705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4U42_RS10710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4U42_RS10715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4U42_RS10720	COG3105	Protein conserved in bacteria
A4U42_RS10725	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A4U42_RS10745	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4U42_RS10750	COG0625	glutathione transferase activity
A4U42_RS10755	COG2969	positive regulation of protein catabolic process
A4U42_RS10765	COG0493	'glutamate synthase
A4U42_RS10770	COG0067	glutamate synthase
A4U42_RS10770	COG0070	glutamate synthase
A4U42_RS10770	COG0069	glutamate synthase activity
A4U42_RS10775	COG1242	4 iron, 4 sulfur cluster binding
A4U42_RS10780	COG5002	protein histidine kinase activity
A4U42_RS10780	COG0784	Response regulator, receiver
A4U42_RS10780	COG2198	Histidine kinase
A4U42_RS10785	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A4U42_RS10790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4U42_RS10800	COG2823	Periplasmic or secreted lipoprotein
A4U42_RS10805	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4U42_RS10810	COG0792	nuclease activity
A4U42_RS10815	COG3107	peptidoglycan biosynthetic process
A4U42_RS10820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4U42_RS10830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4U42_RS10835	COG3384	dioxygenase
A4U42_RS10840	COG0754	glutathionylspermidine amidase activity
A4U42_RS10845	COG5463	Belongs to the UPF0441 family
A4U42_RS10850	COG1538	Outer membrane efflux protein
A4U42_RS10855	COG0494	nUDIX hydrolase
A4U42_RS10860	COG3151	Protein conserved in bacteria
A4U42_RS10865	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4U42_RS10870	COG3150	esterase
A4U42_RS10880	COG0583	DNA-binding transcription factor activity
A4U42_RS10885	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4U42_RS10890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4U42_RS10895	COG0204	Acyl-transferase
A4U42_RS10900	COG2132	Multicopper oxidase
A4U42_RS10905	COG0656	L-ascorbic acid biosynthetic process
A4U42_RS10910	COG1979	alcohol dehydrogenase
A4U42_RS10915	COG2207	Transcriptional regulator
A4U42_RS10920	COG0586	Pfam SNARE associated Golgi protein
A4U42_RS10925	COG0626	cystathionine gamma-synthase activity
A4U42_RS10930	COG0811	peptide transport
A4U42_RS10935	COG0848	biopolymer transport protein
A4U42_RS10980	COG1328	CTP reductase activity
A4U42_RS10990	COG4166	transmembrane transport
A4U42_RS10995	COG0601	transmembrane transport
A4U42_RS11000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS11035	COG2308	Evidence 4 Homologs of previously reported genes of
A4U42_RS11045	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A4U42_RS11050	COG0540	Belongs to the ATCase OTCase family
A4U42_RS11055	COG2731	YhcH YjgK YiaL family protein
A4U42_RS11060	COG2190	(PTS) system
A4U42_RS11060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U42_RS11060	COG1263	PTS System
A4U42_RS11065	COG2723	6-phospho-beta-galactosidase activity
A4U42_RS11070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4U42_RS11085	COG1396	sequence-specific DNA binding
A4U42_RS11090	COG0454	-acetyltransferase
A4U42_RS11095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4U42_RS11100	COG0840	transmembrane signaling receptor activity
A4U42_RS11105	COG0525	valine-tRNA ligase activity
A4U42_RS11110	COG2927	DNA polymerase III (CHI subunit)
A4U42_RS11115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4U42_RS11120	COG0795	lipopolysaccharide-transporting ATPase activity
A4U42_RS11125	COG0795	lipopolysaccharide-transporting ATPase activity
A4U42_RS11135	COG0582	viral genome integration into host DNA
A4U42_RS11205	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A4U42_RS11230	COG4106	trans-aconitate 2-methyltransferase activity
A4U42_RS11250	COG1522	sequence-specific DNA binding
A4U42_RS11270	COG1280	lysine exporter protein (LysE YggA)
A4U42_RS11285	COG2814	Major facilitator Superfamily
A4U42_RS11300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4U42_RS11305	COG1349	DNA-binding transcription factor activity
A4U42_RS11310	COG3959	Transketolase, thiamine diphosphate binding domain
A4U42_RS11315	COG3958	Transketolase
A4U42_RS11320	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS11325	COG1879	ABC-type sugar transport system periplasmic component
A4U42_RS11335	COG1129	ABC transporter
A4U42_RS11340	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U42_RS11345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4U42_RS11375	COG0747	negative chemotaxis
A4U42_RS11385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS11390	COG0444	Belongs to the ABC transporter superfamily
A4U42_RS11395	COG4608	Belongs to the ABC transporter superfamily
A4U42_RS11405	COG0583	DNA-binding transcription factor activity
A4U42_RS11420	COG1605	Chorismate mutase
A4U42_RS11430	COG1418	mRNA catabolic process
A4U42_RS11435	COG1414	Transcriptional regulator
A4U42_RS11440	COG0840	transmembrane signaling receptor activity
A4U42_RS11455	COG0235	Class ii aldolase
A4U42_RS11460	COG4806	L-rhamnose isomerase
A4U42_RS11465	COG1070	Carbohydrate kinase
A4U42_RS11470	COG1917	Cupin 2, conserved barrel domain protein
A4U42_RS11470	COG2169	Transcriptional regulator
A4U42_RS11475	COG4977	sequence-specific DNA binding
A4U42_RS11475	COG1917	Cupin 2, conserved barrel domain protein
A4U42_RS11485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS11495	COG0747	negative chemotaxis
A4U42_RS11500	COG3477	response to acidic pH
A4U42_RS11510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4U42_RS11515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4U42_RS11520	COG0006	proline dipeptidase activity
A4U42_RS11525	COG3079	Belongs to the UPF0149 family
A4U42_RS11530	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A4U42_RS11540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4U42_RS11555	COG0560	Phosphoserine phosphatase
A4U42_RS11560	COG3726	membrane protein affecting hemolysin expression
A4U42_RS11585	COG2823	Periplasmic or secreted lipoprotein
A4U42_RS11600	COG0084	hydrolase, TatD family'
A4U42_RS11610	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A4U42_RS11615	COG0840	transmembrane signaling receptor activity
A4U42_RS11620	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A4U42_RS11635	COG1473	amidohydrolase
A4U42_RS11650	COG1120	ATPase activity
A4U42_RS11660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U42_RS11670	COG3634	alkyl hydroperoxide reductase activity
A4U42_RS11685	COG2351	hydroxyisourate hydrolase activity
A4U42_RS11725	COG1609	Transcriptional regulator
A4U42_RS11770	COG0297	glycogen (starch) synthase activity
A4U42_RS11775	COG0297	glycogen (starch) synthase activity
A4U42_RS11775	COG0438	transferase activity, transferring glycosyl groups
A4U42_RS11790	COG1045	serine acetyltransferase
A4U42_RS11805	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS11820	COG0300	oxidoreductase activity
A4U42_RS11880	COG0582	viral genome integration into host DNA
A4U42_RS11890	COG1309	transcriptional regulator
A4U42_RS11895	COG4232	protein-disulfide reductase activity
A4U42_RS11900	COG1324	tolerance protein
A4U42_RS11905	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4U42_RS11920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4U42_RS11925	COG0459	protein refolding
A4U42_RS11930	COG3161	chorismate lyase activity
A4U42_RS11935	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A4U42_RS11940	COG2937	Belongs to the GPAT DAPAT family
A4U42_RS11945	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A4U42_RS11950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4U42_RS11955	COG0735	belongs to the Fur family
A4U42_RS11960	COG1741	Belongs to the pirin family
A4U42_RS11965	COG0583	DNA-binding transcription factor activity
A4U42_RS11970	COG0435	Glutathione S-transferase
A4U42_RS11975	COG2259	Doxx family
A4U42_RS11985	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
A4U42_RS11990	COG4575	ribosome binding
A4U42_RS12000	COG0586	Pfam SNARE associated Golgi protein
A4U42_RS12010	COG2271	Major facilitator Superfamily
A4U42_RS12015	COG1904	glucuronate isomerase
A4U42_RS12020	COG0246	Mannitol dehydrogenase
A4U42_RS12025	COG2721	sulfolactate sulfo-lyase activity
A4U42_RS12035	COG0861	Integral membrane protein TerC family
A4U42_RS12040	COG2813	Specifically methylates the guanine in position
A4U42_RS12055	COG2197	response regulator
A4U42_RS12065	COG2271	Major facilitator Superfamily
A4U42_RS12070	COG2271	Major facilitator Superfamily
A4U42_RS12075	COG3678	ATP-independent chaperone mediated protein folding
A4U42_RS12085	COG1477	protein flavinylation
A4U42_RS12110	COG0667	Aldo Keto reductase
A4U42_RS12125	COG0604	alcohol dehydrogenase
A4U42_RS12155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4U42_RS12160	COG0358	DNA primase activity
A4U42_RS12165	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A4U42_RS12170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4U42_RS12175	COG1438	arginine binding
A4U42_RS12195	COG0142	geranyltranstransferase activity
A4U42_RS12200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4U42_RS12210	COG0697	spore germination
A4U42_RS12215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4U42_RS12220	COG2027	D-alanyl-D-alanine carboxypeptidase
A4U42_RS12230	COG1534	Rna-binding protein
A4U42_RS12235	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A4U42_RS12240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4U42_RS12245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4U42_RS12250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4U42_RS12255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4U42_RS12270	COG0779	Required for maturation of 30S ribosomal subunits
A4U42_RS12275	COG0195	Participates in both transcription termination and antitermination
A4U42_RS12280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4U42_RS12285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4U42_RS12290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4U42_RS12295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4U42_RS12300	COG1185	polyribonucleotide nucleotidyltransferase activity
A4U42_RS12310	COG0513	Belongs to the DEAD box helicase family
A4U42_RS12315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U42_RS12320	COG0826	peptidase U32
A4U42_RS12325	COG0826	peptidase U32
A4U42_RS12330	COG3154	lipid carrier protein
A4U42_RS12335	COG3153	acetyltransferase
A4U42_RS12340	COG2827	Endonuclease containing a URI domain
A4U42_RS12345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A4U42_RS12350	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A4U42_RS12355	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A4U42_RS12360	COG0813	purine-nucleoside phosphorylase activity
A4U42_RS12390	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A4U42_RS12395	COG2813	Specifically methylates the guanine in position
A4U42_RS12400	COG0667	Aldo Keto reductase
A4U42_RS12405	COG0583	DNA-binding transcription factor activity
A4U42_RS12465	COG1454	alcohol dehydrogenase
A4U42_RS12470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A4U42_RS12475	COG0509	glycine decarboxylation via glycine cleavage system
A4U42_RS12480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4U42_RS12480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4U42_RS12485	COG1280	lysine exporter protein (LysE YggA)
A4U42_RS12495	COG1272	protein, Hemolysin III
A4U42_RS12500	COG0354	folic acid binding
A4U42_RS12505	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A4U42_RS12515	COG0716	FMN binding
A4U42_RS12520	COG0477	Major facilitator Superfamily
A4U42_RS12525	COG4974	Belongs to the 'phage' integrase family
A4U42_RS12530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4U42_RS12535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4U42_RS12540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4U42_RS12570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U42_RS12580	COG0642	Histidine kinase
A4U42_RS12595	COG0671	phosphoesterase, PA-phosphatase related
A4U42_RS12600	COG1733	regulation of RNA biosynthetic process
A4U42_RS12615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4U42_RS12620	COG1653	transport
A4U42_RS12630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4U42_RS12635	COG0395	ABC-type sugar transport system, permease component
A4U42_RS12640	COG1175	transmembrane transport
A4U42_RS12650	COG1560	Kdo2-lipid A biosynthetic process
A4U42_RS12655	COG2252	PERMEase
A4U42_RS12660	COG0025	NhaP-type Na H and K H
A4U42_RS12665	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4U42_RS12670	COG3162	membrane
A4U42_RS12675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4U42_RS12690	COG4948	Mandelate Racemase Muconate Lactonizing
A4U42_RS12695	COG0747	negative chemotaxis
A4U42_RS12700	COG0601	transmembrane transport
A4U42_RS12705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS12710	COG0444	Belongs to the ABC transporter superfamily
A4U42_RS12715	COG4608	Belongs to the ABC transporter superfamily
A4U42_RS12725	COG3712	iron ion homeostasis
A4U42_RS12745	COG0246	Mannitol dehydrogenase
A4U42_RS12750	COG2814	Major facilitator Superfamily
A4U42_RS12760	COG1846	Transcriptional regulator
A4U42_RS12765	COG1376	ErfK ybiS ycfS ynhG family protein
A4U42_RS12770	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4U42_RS12770	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4U42_RS12770	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4U42_RS12770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4U42_RS12785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U42_RS12790	COG0765	amino acid transport
A4U42_RS12795	COG0765	amino acid transport
A4U42_RS12835	COG2211	Major facilitator Superfamily
A4U42_RS12855	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4U42_RS12880	COG2814	Major facilitator Superfamily
A4U42_RS12885	COG0583	DNA-binding transcription factor activity
A4U42_RS12905	COG3962	Belongs to the TPP enzyme family
A4U42_RS12910	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A4U42_RS12935	COG4133	protoheme IX ABC transporter activity
A4U42_RS12940	COG0673	inositol 2-dehydrogenase activity
A4U42_RS12955	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U42_RS12960	COG0673	inositol 2-dehydrogenase activity
A4U42_RS12965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U42_RS12975	COG3718	enzyme involved in inositol metabolism
A4U42_RS12980	COG2951	lytic endotransglycosylase activity
A4U42_RS12985	COG0583	DNA-binding transcription factor activity
A4U42_RS12990	COG2271	Major facilitator Superfamily
A4U42_RS12995	COG4948	Mandelate Racemase Muconate Lactonizing
A4U42_RS13010	COG2801	Transposase and inactivated derivatives
A4U42_RS13020	COG2801	Transposase and inactivated derivatives
A4U42_RS13025	COG2963	transposase activity
A4U42_RS13075	COG2916	Histone family protein nucleoid-structuring protein H-NS
A4U42_RS13090	COG3423	Transcriptional regulator
A4U42_RS13105	COG4104	PAAR repeat-containing protein
A4U42_RS13105	COG3209	COG3209 Rhs family protein
A4U42_RS13115	COG3501	Rhs element vgr protein
A4U42_RS13135	COG2867	negative regulation of translational initiation
A4U42_RS13140	COG2914	Belongs to the UPF0125 (RnfH) family
A4U42_RS13150	COG0497	DNA recombination
A4U42_RS13155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4U42_RS13160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4U42_RS13165	COG1914	H( )-stimulated, divalent metal cation uptake system
A4U42_RS13170	COG0494	nUDIX hydrolase
A4U42_RS13175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4U42_RS13185	COG1671	Belongs to the UPF0178 family
A4U42_RS13190	COG0408	coproporphyrinogen oxidase activity
A4U42_RS13195	COG0456	acetyltransferase
A4U42_RS13200	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A4U42_RS13205	COG4771	TonB-dependent receptor
A4U42_RS13210	COG0612	Peptidase, M16
A4U42_RS13215	COG4178	(ABC) transporter
A4U42_RS13230	COG3423	Transcriptional regulator
A4U42_RS13245	COG2837	iron assimilation
A4U42_RS13255	COG3157	Type VI secretion system effector, Hcp
A4U42_RS13270	COG0577	efflux transmembrane transporter activity
A4U42_RS13270	COG1136	(ABC) transporter
A4U42_RS13275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U42_RS13280	COG0745	RESPONSE REGULATOR receiver
A4U42_RS13285	COG2205	protein histidine kinase activity
A4U42_RS13290	COG1024	Enoyl-CoA hydratase
A4U42_RS13295	COG1733	regulation of RNA biosynthetic process
A4U42_RS13300	COG2190	(PTS) system
A4U42_RS13310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U42_RS13320	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
A4U42_RS13325	COG3115	cell septum assembly
A4U42_RS13330	COG0531	amino acid
A4U42_RS13340	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4U42_RS13350	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4U42_RS13355	COG1773	rubredoxin
A4U42_RS13355	COG0426	domain, Protein
A4U42_RS13360	COG3604	Transcriptional regulator
A4U42_RS13365	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4U42_RS13365	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4U42_RS13390	COG3976	FMN-binding domain protein
A4U42_RS13390	COG0431	NADPH-dependent FMN reductase
A4U42_RS13390	COG1053	succinate dehydrogenase
A4U42_RS13395	COG3976	FMN-binding domain protein
A4U42_RS13395	COG1053	succinate dehydrogenase
A4U42_RS13395	COG0431	NADPH-dependent FMN reductase
A4U42_RS13400	COG0477	Major facilitator Superfamily
A4U42_RS13405	COG3301	Polysulphide reductase, NrfD
A4U42_RS13410	COG0437	4 iron, 4 sulfur cluster binding
A4U42_RS13425	COG1609	Transcriptional regulator
A4U42_RS13430	COG1234	tRNA 3'-trailer cleavage
A4U42_RS13435	COG3842	ATPase activity
A4U42_RS13445	COG1175	transmembrane transport
A4U42_RS13460	COG0473	3-isopropylmalate dehydrogenase activity
A4U42_RS13465	COG0583	DNA-binding transcription factor activity
A4U42_RS13470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A4U42_RS13470	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A4U42_RS13490	COG2862	Uncharacterized protein family, UPF0114
A4U42_RS13525	COG0745	RESPONSE REGULATOR receiver
A4U42_RS13530	COG5002	protein histidine kinase activity
A4U42_RS13540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U42_RS13550	COG1733	regulation of RNA biosynthetic process
A4U42_RS13595	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A4U42_RS13605	COG0583	DNA-binding transcription factor activity
A4U42_RS13610	COG0577	efflux transmembrane transporter activity
A4U42_RS13610	COG1136	(ABC) transporter
A4U42_RS13620	COG0577	efflux transmembrane transporter activity
A4U42_RS13620	COG1136	(ABC) transporter
A4U42_RS13660	COG0534	Mate efflux family protein
A4U42_RS13680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U42_RS13685	COG0300	oxidoreductase activity
A4U42_RS13700	COG0667	Aldo Keto reductase
A4U42_RS13705	COG0604	alcohol dehydrogenase
A4U42_RS13725	COG1982	Orn Lys Arg decarboxylase major
A4U42_RS13735	COG0741	lytic transglycosylase activity
A4U42_RS13740	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A4U42_RS13750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4U42_RS13755	COG3171	Protein conserved in bacteria
A4U42_RS13770	COG0667	Aldo Keto reductase
A4U42_RS13780	COG0861	Integral membrane protein TerC family
A4U42_RS13785	COG3066	DNA modification
A4U42_RS13790	COG0494	nUDIX hydrolase
A4U42_RS13800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4U42_RS13805	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A4U42_RS13810	COG2165	general secretion pathway protein
A4U42_RS13815	COG4795	General secretion pathway protein
A4U42_RS13830	COG1025	Belongs to the peptidase M16 family
A4U42_RS13835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4U42_RS13835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A4U42_RS13840	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4U42_RS13855	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A4U42_RS13865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4U42_RS13875	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4U42_RS13880	COG2166	iron-sulfur cluster assembly
A4U42_RS13885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4U42_RS13890	COG0583	DNA-binding transcription factor activity
A4U42_RS13895	COG2363	Small membrane protein
A4U42_RS13900	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A4U42_RS13905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4U42_RS13910	COG1611	Belongs to the LOG family
A4U42_RS13940	COG2171	N-acyltransferase activity
A4U42_RS13945	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A4U42_RS13960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4U42_RS13965	COG0528	UMP kinase activity
A4U42_RS13970	COG0233	cytoplasmic translational termination
A4U42_RS13975	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4U42_RS13980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4U42_RS13985	COG0575	Belongs to the CDS family
A4U42_RS13990	COG0750	zinc metalloprotease
A4U42_RS13995	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4U42_RS14000	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A4U42_RS14005	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4U42_RS14010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4U42_RS14015	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4U42_RS14020	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4U42_RS14025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4U42_RS14030	COG0587	DNA-directed DNA polymerase activity
A4U42_RS14035	COG0825	malonyl-CoA metabolic process
A4U42_RS14040	COG0346	lactoylglutathione lyase activity
A4U42_RS14045	COG0037	tRNA processing
A4U42_RS14050	COG4568	rho-dependent transcription termination
A4U42_RS14060	COG4681	YaeQ
A4U42_RS14065	COG3015	lipoprotein NlpE involved in copper resistance
A4U42_RS14070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4U42_RS14090	COG0778	Nitroreductase
A4U42_RS14105	COG1881	PFAM PEBP family protein
A4U42_RS14135	COG2192	nodulation
A4U42_RS14160	COG2423	ornithine cyclodeaminase activity
A4U42_RS14170	COG0583	DNA-binding transcription factor activity
A4U42_RS14185	COG0546	phosphoglycolate phosphatase activity
A4U42_RS14200	COG2824	Alkylphosphonate utilization operon protein PhnA
A4U42_RS14205	COG3706	GGDEF domain
A4U42_RS14230	COG0583	DNA-binding transcription factor activity
A4U42_RS14255	COG0583	DNA-binding transcription factor activity
A4U42_RS14270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4U42_RS14275	COG4615	Cyclic peptide transporter
A4U42_RS14290	COG3123	guanosine phosphorylase activity
A4U42_RS14295	COG0840	transmembrane signaling receptor activity
A4U42_RS14300	COG2974	May be involved in recombination
A4U42_RS14305	COG1940	carbohydrate kinase activity
A4U42_RS14310	COG0419	ATPase involved in DNA repair
A4U42_RS14315	COG0420	3'-5' exonuclease activity
A4U42_RS14325	COG5002	protein histidine kinase activity
A4U42_RS14335	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4U42_RS14350	COG0450	alkyl hydroperoxide reductase
A4U42_RS14355	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A4U42_RS14360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4U42_RS14365	COG0343	queuine tRNA-ribosyltransferase activity
A4U42_RS14370	COG1862	Preprotein translocase
A4U42_RS14375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4U42_RS14380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4U42_RS14385	COG4238	major outer membrane lipoprotein
A4U42_RS14390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4U42_RS14395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4U42_RS14400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4U42_RS14400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4U42_RS14405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A4U42_RS14410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4U42_RS14415	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A4U42_RS14420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A4U42_RS14425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4U42_RS14430	COG0142	geranyltranstransferase activity
A4U42_RS14435	COG1722	exodeoxyribonuclease VII activity
A4U42_RS14440	COG0301	tRNA thio-modification
A4U42_RS14440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4U42_RS14445	COG0693	protein deglycase activity
A4U42_RS14450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4U42_RS14455	COG1666	GTP binding
A4U42_RS14465	COG2814	Major facilitator Superfamily
A4U42_RS14485	COG0109	protoheme IX farnesyltransferase activity
A4U42_RS14490	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A4U42_RS14495	COG1845	cytochrome c oxidase, subunit III
A4U42_RS14500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4U42_RS14505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A4U42_RS14510	COG2223	nitrite transmembrane transporter activity
A4U42_RS14515	COG3056	Lipoprotein
A4U42_RS14520	COG0271	Belongs to the BolA IbaG family
A4U42_RS14525	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4U42_RS14530	COG0740	serine-type endopeptidase activity
A4U42_RS14535	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4U42_RS14540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4U42_RS14545	COG0776	regulation of translation
A4U42_RS14550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4U42_RS14555	COG1555	photosystem II stabilization
A4U42_RS14560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A4U42_RS14570	COG1522	sequence-specific DNA binding
A4U42_RS14575	COG1132	(ABC) transporter
A4U42_RS14580	COG1132	(ABC) transporter
A4U42_RS14585	COG0347	Belongs to the P(II) protein family
A4U42_RS14590	COG0004	ammonium transporteR
A4U42_RS14595	COG1946	Acyl-CoA thioesterase
A4U42_RS14600	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A4U42_RS14605	COG3695	enzyme binding
A4U42_RS14625	COG0254	rRNA binding
A4U42_RS14630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U42_RS14635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U42_RS14640	COG1309	transcriptional regulator
A4U42_RS14645	COG3264	Mechanosensitive ion channel
A4U42_RS14645	COG1196	nuclear chromosome segregation
A4U42_RS14665	COG2832	Protein of unknown function (DUF454)
A4U42_RS14670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4U42_RS14680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4U42_RS14685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4U42_RS14690	COG0326	Molecular chaperone. Has ATPase activity
A4U42_RS14695	COG0563	adenylate kinase activity
A4U42_RS14700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A4U42_RS14705	COG4651	solute:proton antiporter activity
A4U42_RS14705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4U42_RS14710	COG0737	Belongs to the 5'-nucleotidase family
A4U42_RS14720	COG0840	transmembrane signaling receptor activity
A4U42_RS14735	COG3735	TraB family
A4U42_RS14740	COG2217	Heavy metal translocating P-type atpase
A4U42_RS14745	COG0789	Transcriptional regulator
A4U42_RS14750	COG1585	Membrane protein implicated in regulation of membrane protease activity
A4U42_RS14755	COG0330	HflC and HflK could
A4U42_RS14760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4U42_RS14770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4U42_RS14775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4U42_RS14785	COG2205	protein histidine kinase activity
A4U42_RS14785	COG0784	Response regulator, receiver
A4U42_RS14795	COG0642	Histidine kinase
A4U42_RS14795	COG2198	Histidine kinase
A4U42_RS14800	COG2223	nitrite transmembrane transporter activity
A4U42_RS14805	COG1169	isochorismate synthase
A4U42_RS14810	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A4U42_RS14815	COG0596	Alpha beta hydrolase
A4U42_RS14820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A4U42_RS14825	COG1441	menaquinone biosynthetic process
A4U42_RS14845	COG3118	belongs to the thioredoxin family
A4U42_RS14850	COG0300	oxidoreductase activity
A4U42_RS14855	COG2755	lipolytic protein G-D-S-L family
A4U42_RS14860	COG4181	ATPase activity
A4U42_RS14865	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A4U42_RS14875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4U42_RS14880	COG0765	amino acid transport
A4U42_RS14885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U42_RS14900	COG1879	ABC-type sugar transport system periplasmic component
A4U42_RS14910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4U42_RS14915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4U42_RS14920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A4U42_RS14925	COG2233	PERMEase
A4U42_RS14930	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4U42_RS14935	COG1393	Belongs to the ArsC family
A4U42_RS14940	COG4783	chaperone-mediated protein folding
A4U42_RS14945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4U42_RS14950	COG2716	regulation of RNA biosynthetic process
A4U42_RS14960	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A4U42_RS14965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4U42_RS14970	COG2707	UPF0756 membrane protein
A4U42_RS14975	COG1444	tRNA N-acetyltransferase activity
A4U42_RS14980	COG0400	carboxylic ester hydrolase activity
A4U42_RS14990	COG1876	peptidase activity
A4U42_RS14995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4U42_RS15000	COG1393	Belongs to the ArsC family
A4U42_RS15010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4U42_RS15015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4U42_RS15020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4U42_RS15025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4U42_RS15030	COG0321	lipoyl(octanoyl) transferase activity
A4U42_RS15035	COG2921	Belongs to the UPF0250 family
A4U42_RS15040	COG1686	Belongs to the peptidase S11 family
A4U42_RS15045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4U42_RS15050	COG0772	Belongs to the SEDS family
A4U42_RS15055	COG0768	penicillin binding
A4U42_RS15060	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A4U42_RS15065	COG0799	negative regulation of ribosome biogenesis
A4U42_RS15070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4U42_RS15075	COG1466	dna polymerase III delta subunit
A4U42_RS15080	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A4U42_RS15085	COG0495	leucyl-tRNA aminoacylation
A4U42_RS15090	COG2888	peptidyl-tyrosine sulfation
A4U42_RS15095	COG1126	abc transporter atp-binding protein
A4U42_RS15100	COG0765	amino acid transport
A4U42_RS15105	COG0765	amino acid transport
A4U42_RS15115	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A4U42_RS15120	COG4535	Mg2 and Co2 transporter CorC
A4U42_RS15125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4U42_RS15130	COG1702	phosphate starvation-inducible protein PhoH
A4U42_RS15135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4U42_RS15140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4U42_RS15180	COG0367	asparagine synthase
A4U42_RS15185	COG1846	Transcriptional regulator
A4U42_RS15185	COG1940	carbohydrate kinase activity
A4U42_RS15190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4U42_RS15195	COG0363	glucosamine-6-phosphate deaminase activity
A4U42_RS15200	COG1263	PTS System
A4U42_RS15200	COG2190	(PTS) system
A4U42_RS15200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U42_RS15205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4U42_RS15210	COG0735	belongs to the Fur family
A4U42_RS15220	COG0840	transmembrane signaling receptor activity
A4U42_RS15230	COG0596	Alpha beta hydrolase
A4U42_RS15235	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A4U42_RS15240	COG0033	Phosphoglucomutase
A4U42_RS15250	COG0745	RESPONSE REGULATOR receiver
A4U42_RS15255	COG2205	protein histidine kinase activity
A4U42_RS15260	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A4U42_RS15265	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A4U42_RS15270	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A4U42_RS15285	COG3272	Protein of unknown function (DUF1722)
A4U42_RS15290	COG0415	Belongs to the DNA photolyase family
A4U42_RS15295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4U42_RS15300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A4U42_RS15305	COG1984	allophanate hydrolase subunit 2
A4U42_RS15310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A4U42_RS15315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4U42_RS15320	COG0372	Belongs to the citrate synthase family
A4U42_RS15330	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A4U42_RS15335	COG1053	succinate dehydrogenase
A4U42_RS15340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4U42_RS15345	COG0567	Dehydrogenase, E1 component
A4U42_RS15350	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4U42_RS15360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4U42_RS15365	COG1271	oxidase subunit
A4U42_RS15370	COG1294	oxidase, subunit
A4U42_RS15375	COG4890	Cyd operon protein YbgT
A4U42_RS15380	COG3790	cyd operon protein YbgE
A4U42_RS15385	COG0824	Thioesterase
A4U42_RS15390	COG0811	peptide transport
A4U42_RS15395	COG0848	biopolymer transport protein
A4U42_RS15400	COG3064	Membrane
A4U42_RS15405	COG0823	Involved in the tonB-independent uptake of proteins
A4U42_RS15410	COG2885	chlorophyll binding
A4U42_RS15415	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A4U42_RS15440	COG1811	Na channel or pump
A4U42_RS15445	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4U42_RS15455	COG1230	cation diffusion facilitator family transporter
A4U42_RS15460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4U42_RS15465	COG0588	phosphoglycerate mutase activity
A4U42_RS15470	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U42_RS15475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U42_RS15495	COG2017	converts alpha-aldose to the beta-anomer
A4U42_RS15505	COG1085	galactose-1-phosphate uridylyltransferase
A4U42_RS15510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4U42_RS15515	COG1119	ATPase activity
A4U42_RS15520	COG2005	Transcriptional regulator
A4U42_RS15520	COG3585	molybdate ion transport
A4U42_RS15525	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4U42_RS15530	COG4149	molybdate abc transporter
A4U42_RS15535	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A4U42_RS15545	COG0561	phosphatase activity
A4U42_RS15550	COG2706	6-phosphogluconolactonase activity
A4U42_RS15570	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4U42_RS15570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4U42_RS15575	COG0489	protein tyrosine kinase activity
A4U42_RS15585	COG0717	Belongs to the dCTP deaminase family
A4U42_RS15590	COG2982	Protein involved in outer membrane biogenesis
A4U42_RS15595	COG1253	flavin adenine dinucleotide binding
A4U42_RS15645	COG1088	dTDP-glucose 4,6-dehydratase activity
A4U42_RS15665	COG1215	transferase activity, transferring glycosyl groups
A4U42_RS15670	COG2244	polysaccharide biosynthetic process
A4U42_RS15700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4U42_RS15730	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4U42_RS15745	COG3706	GGDEF domain
A4U42_RS15765	COG2990	Protein conserved in bacteria
A4U42_RS15780	COG3720	iron ion transport
A4U42_RS15785	COG4558	Periplasmic binding protein
A4U42_RS15790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U42_RS15795	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A4U42_RS15805	COG2706	6-phosphogluconolactonase activity
A4U42_RS15810	COG0783	Belongs to the Dps family
A4U42_RS15815	COG2267	carboxylic ester hydrolase activity
A4U42_RS15835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS15840	COG0444	Belongs to the ABC transporter superfamily
A4U42_RS15845	COG4608	Belongs to the ABC transporter superfamily
A4U42_RS15855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4U42_RS15865	COG3501	Rhs element vgr protein
A4U42_RS15890	COG3209	COG3209 Rhs family protein
A4U42_RS15905	COG3209	COG3209 Rhs family protein
A4U42_RS15920	COG1473	amidohydrolase
A4U42_RS15975	COG3829	transcription factor binding
A4U42_RS16015	COG4948	Mandelate Racemase Muconate Lactonizing
A4U42_RS16025	COG4251	negative regulation of phosphorylation
A4U42_RS16025	COG3706	GGDEF domain
A4U42_RS16025	COG2203	Gaf domain
A4U42_RS16025	COG5001	Diguanylate cyclase
A4U42_RS16030	COG0672	)-iron permease
A4U42_RS16045	COG3813	Protein conserved in bacteria
A4U42_RS16060	COG1136	(ABC) transporter
A4U42_RS16060	COG0577	efflux transmembrane transporter activity
A4U42_RS16080	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A4U42_RS16080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4U42_RS16080	COG3321	synthase
A4U42_RS16085	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4U42_RS16085	COG2070	2-Nitropropane dioxygenase
A4U42_RS16090	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS16120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U42_RS16140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U42_RS16145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U42_RS16150	COG0745	RESPONSE REGULATOR receiver
A4U42_RS16155	COG5002	protein histidine kinase activity
A4U42_RS16160	COG0583	DNA-binding transcription factor activity
A4U42_RS16170	COG0436	Aminotransferase
A4U42_RS16190	COG0730	response to heat
A4U42_RS16195	COG0488	(ABC) transporter
A4U42_RS16210	COG1556	Lactate utilization protein
A4U42_RS16215	COG1139	Iron-sulfur cluster binding protein
A4U42_RS16220	COG0247	lactate metabolic process
A4U42_RS16225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4U42_RS16235	COG1346	cytolysis
A4U42_RS16245	COG4566	intracellular signal transduction
A4U42_RS16250	COG4191	Histidine kinase
A4U42_RS16255	COG1116	anion transmembrane transporter activity
A4U42_RS16260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U42_RS16265	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A4U42_RS16270	COG0768	penicillin binding
A4U42_RS16275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4U42_RS16280	COG0747	negative chemotaxis
A4U42_RS16285	COG0601	transmembrane transport
A4U42_RS16295	COG0444	Belongs to the ABC transporter superfamily
A4U42_RS16300	COG1124	(ABC) transporter
A4U42_RS16305	COG1846	Transcriptional regulator
A4U42_RS16310	COG1566	PFAM secretion protein HlyD family protein
A4U42_RS16315	COG2814	Major facilitator Superfamily
A4U42_RS16320	COG3708	Transcriptional regulator
A4U42_RS16320	COG2207	Transcriptional regulator
A4U42_RS16340	COG3615	Tellurite resistance protein tehB
A4U42_RS16350	COG2814	Major facilitator Superfamily
A4U42_RS16385	COG2207	Transcriptional regulator
A4U42_RS16390	COG2315	Protein conserved in bacteria
A4U42_RS16415	COG0582	viral genome integration into host DNA
A4U42_RS16425	COG3250	beta-galactosidase activity
A4U42_RS16430	COG1609	Transcriptional regulator
A4U42_RS16440	COG0583	DNA-binding transcription factor activity
A4U42_RS16445	COG1301	dicarboxylic acid transport
A4U42_RS16455	COG3383	formate dehydrogenase (NAD+) activity
A4U42_RS16460	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4U42_RS16475	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4U42_RS16485	COG3260	NADH ubiquinone oxidoreductase 20
A4U42_RS16490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4U42_RS16495	COG3261	NADH dehydrogenase
A4U42_RS16495	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A4U42_RS16500	COG0651	ATP synthesis coupled electron transport
A4U42_RS16505	COG4237	Hydrogenase 4 membrane
A4U42_RS16510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4U42_RS16515	COG0650	Formate hydrogenlyase subunit 4
A4U42_RS16520	COG0651	ATP synthesis coupled electron transport
A4U42_RS16525	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4U42_RS16530	COG0298	carbon dioxide binding
A4U42_RS16535	COG0697	spore germination
A4U42_RS16540	COG0583	DNA-binding transcription factor activity
A4U42_RS16545	COG1301	dicarboxylic acid transport
A4U42_RS16550	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4U42_RS16560	COG0625	glutathione transferase activity
A4U42_RS16570	COG0583	DNA-binding transcription factor activity
A4U42_RS16580	COG1064	alcohol dehydrogenase
A4U42_RS16590	COG0667	Aldo Keto reductase
A4U42_RS16620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U42_RS16625	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A4U42_RS16635	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4U42_RS16640	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A4U42_RS16650	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4U42_RS16655	COG1012	belongs to the aldehyde dehydrogenase family
A4U42_RS16660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4U42_RS16670	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS16675	COG0300	oxidoreductase activity
A4U42_RS16680	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4U42_RS16685	COG0702	epimerase
A4U42_RS16705	COG2188	Transcriptional regulator
A4U42_RS16710	COG3624	Phosphonate C-P lyase system protein PhnG
A4U42_RS16715	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
A4U42_RS16720	COG3626	phosphonate metabolism
A4U42_RS16725	COG3627	carbon phosphorus lyase activity
A4U42_RS16730	COG4107	phosphonate C-P lyase system protein PhnK
A4U42_RS16735	COG4778	phosphonate C-P lyase system protein PhnL
A4U42_RS16740	COG3454	Phosphonate metabolism
A4U42_RS16745	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A4U42_RS16750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4U42_RS16760	COG0583	DNA-binding transcription factor activity
A4U42_RS16770	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A4U42_RS16785	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4U42_RS16800	COG0019	diaminopimelate decarboxylase activity
A4U42_RS16805	COG2814	Major facilitator Superfamily
A4U42_RS16810	COG4264	IucA IucC family
A4U42_RS16820	COG4264	IucA IucC family
A4U42_RS16825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4U42_RS16830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U42_RS16835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U42_RS16840	COG1120	ATPase activity
A4U42_RS16845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4U42_RS16850	COG1598	PFAM Uncharacterised protein family UPF0150
A4U42_RS16860	COG3383	formate dehydrogenase (NAD+) activity
A4U42_RS16860	COG0243	molybdopterin cofactor binding
A4U42_RS16865	COG0437	4 iron, 4 sulfur cluster binding
A4U42_RS16870	COG2864	formate dehydrogenase
A4U42_RS16885	COG2211	Major facilitator Superfamily
A4U42_RS16905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4U42_RS16910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4U42_RS16920	COG2199	diguanylate cyclase activity
A4U42_RS16925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U42_RS16970	COG3416	Protein conserved in bacteria
A4U42_RS16990	COG2011	ABC-type metal ion transport system permease component
A4U42_RS16995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4U42_RS17020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U42_RS17025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4U42_RS17045	COG2134	cdp-diacylglycerol pyrophosphatase
A4U42_RS17055	COG4166	transmembrane transport
A4U42_RS17060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4U42_RS17065	COG1957	nucleoside hydrolase
A4U42_RS17075	COG0601	transmembrane transport
A4U42_RS17100	COG2964	Protein conserved in bacteria
A4U42_RS17110	COG0835	chemotaxis
A4U42_RS17110	COG0784	Response regulator, receiver
A4U42_RS17140	COG0679	Auxin Efflux Carrier
A4U42_RS17150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4U42_RS17160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4U42_RS17165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4U42_RS17170	COG1121	(ABC) transporter
A4U42_RS17175	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4U42_RS17185	COG0697	spore germination
A4U42_RS17190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U42_RS17200	COG1984	allophanate hydrolase subunit 2
A4U42_RS17205	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A4U42_RS17210	COG0436	Aminotransferase
A4U42_RS17225	COG4221	oxidoreductase activity
A4U42_RS17230	COG0765	amino acid transport
A4U42_RS17235	COG0765	amino acid transport
A4U42_RS17250	COG2186	Transcriptional regulator
A4U42_RS17255	COG3734	2-keto-3-deoxy-galactonokinase
A4U42_RS17260	COG0800	Aldolase
A4U42_RS17265	COG4948	Mandelate Racemase Muconate Lactonizing
A4U42_RS17270	COG2271	Major facilitator Superfamily
A4U42_RS17275	COG0583	DNA-binding transcription factor activity
A4U42_RS17280	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS17330	COG0582	viral genome integration into host DNA
A4U42_RS17355	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
A4U42_RS17365	COG3504	Conjugal transfer protein
A4U42_RS17405	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4U42_RS17410	COG0667	Aldo Keto reductase
A4U42_RS17460	COG3423	Transcriptional regulator
A4U42_RS17465	COG1476	TRANSCRIPTIONal
A4U42_RS17475	COG3501	Rhs element vgr protein
A4U42_RS17505	COG5489	Protein of unknown function (DUF736)
A4U42_RS17520	COG3228	Belongs to the MtfA family
A4U42_RS17535	COG1396	sequence-specific DNA binding
A4U42_RS17540	COG0401	homolog of Blt101
A4U42_RS17550	COG0463	Glycosyl transferase, family 2
A4U42_RS17550	COG0457	Tetratricopeptide repeat
A4U42_RS17555	COG1607	acyl-coa hydrolase
A4U42_RS17560	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4U42_RS17565	COG0303	'Molybdopterin
A4U42_RS17570	COG0281	malic enzyme
A4U42_RS17575	COG0295	cytidine deaminase activity
A4U42_RS17585	COG1346	cytolysis
A4U42_RS17590	COG1380	Effector of murein hydrolase LrgA
A4U42_RS17605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4U42_RS17610	COG0156	8-amino-7-oxononanoate synthase activity
A4U42_RS17615	COG2226	methyltransferase
A4U42_RS17620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4U42_RS17625	COG0556	nucleotide-excision repair
A4U42_RS17635	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A4U42_RS17640	COG1271	oxidase subunit
A4U42_RS17645	COG1294	oxidase, subunit
A4U42_RS17650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4U42_RS17655	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4U42_RS17665	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A4U42_RS17690	COG0670	Belongs to the BI1 family
A4U42_RS17695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4U42_RS17700	COG3568	Endonuclease Exonuclease Phosphatase
A4U42_RS17705	COG0842	Transport permease protein
A4U42_RS17710	COG0842	Transport permease protein
A4U42_RS17715	COG1131	(ABC) transporter
A4U42_RS17720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U42_RS17725	COG0513	Belongs to the DEAD box helicase family
A4U42_RS17730	COG0697	spore germination
A4U42_RS17745	COG0444	Belongs to the ABC transporter superfamily
A4U42_RS17760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS17765	COG0584	glycerophosphoryl diester phosphodiesterase
A4U42_RS17775	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4U42_RS17780	COG0747	negative chemotaxis
A4U42_RS17785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4U42_RS17795	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4U42_RS17800	COG1686	Belongs to the peptidase S11 family
A4U42_RS17810	COG1349	DNA-binding transcription factor activity
A4U42_RS17820	COG1472	Belongs to the glycosyl hydrolase 3 family
A4U42_RS17835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4U42_RS17845	COG0671	phosphoesterase, PA-phosphatase related
A4U42_RS17850	COG0671	phosphoesterase, PA-phosphatase related
A4U42_RS17860	COG1126	abc transporter atp-binding protein
A4U42_RS17865	COG0765	amino acid transport
A4U42_RS17870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U42_RS17875	COG0783	Belongs to the Dps family
A4U42_RS17885	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A4U42_RS17890	COG1846	Transcriptional regulator
A4U42_RS17895	COG2807	transmembrane transport
A4U42_RS17900	COG0583	DNA-binding transcription factor activity
A4U42_RS17925	COG1984	allophanate hydrolase subunit 2
A4U42_RS17940	COG1136	(ABC) transporter
A4U42_RS17945	COG1136	(ABC) transporter
A4U42_RS17945	COG0577	efflux transmembrane transporter activity
A4U42_RS17960	COG4677	pectinesterase activity
A4U42_RS17965	COG3136	membrane protein required for alginate biosynthesis
A4U42_RS17980	COG0601	transmembrane transport
A4U42_RS17985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS17990	COG0444	Belongs to the ABC transporter superfamily
A4U42_RS17995	COG4608	Belongs to the ABC transporter superfamily
A4U42_RS18040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U42_RS18070	COG3082	Protein of unknown function (DUF1414)
A4U42_RS18075	COG3081	Nucleoid-associated protein
A4U42_RS18080	COG3275	phosphorelay sensor kinase activity
A4U42_RS18085	COG3279	Response regulator of the LytR AlgR family
A4U42_RS18090	COG2223	nitrite transmembrane transporter activity
A4U42_RS18095	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A4U42_RS18100	COG1061	Type III restriction enzyme res subunit
A4U42_RS18115	COG2814	Major facilitator Superfamily
A4U42_RS18125	COG4172	Belongs to the ABC transporter superfamily
A4U42_RS18130	COG4239	(ABC) transporter, permease
A4U42_RS18135	COG4174	ABC transporter (Permease)
A4U42_RS18140	COG4166	transmembrane transport
A4U42_RS18145	COG0791	NLP P60 protein
A4U42_RS18150	COG0671	phosphoesterase, PA-phosphatase related
A4U42_RS18155	COG0523	cobalamin synthesis protein
A4U42_RS18160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4U42_RS18180	COG1105	Belongs to the carbohydrate kinase PfkB family
A4U42_RS18185	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A4U42_RS18185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4U42_RS18185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4U42_RS18195	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A4U42_RS18200	COG2855	membrane
A4U42_RS18205	COG0583	DNA-binding transcription factor activity
A4U42_RS18210	COG0833	amino acid
A4U42_RS18220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4U42_RS18235	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4U42_RS18245	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U42_RS18250	COG1129	ABC transporter
A4U42_RS18255	COG0371	Dehydrogenase
A4U42_RS18275	COG0583	DNA-binding transcription factor activity
A4U42_RS18280	COG0840	transmembrane signaling receptor activity
A4U42_RS18290	COG0840	transmembrane signaling receptor activity
A4U42_RS18305	COG0302	gtp cyclohydrolase
A4U42_RS18310	COG2311	Membrane
A4U42_RS18315	COG2949	membrane
A4U42_RS18320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4U42_RS18325	COG2133	pyrroloquinoline quinone binding
A4U42_RS18330	COG0625	glutathione transferase activity
A4U42_RS18335	COG1464	Belongs to the NlpA lipoprotein family
A4U42_RS18340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4U42_RS18345	COG2011	ABC-type metal ion transport system permease component
A4U42_RS18350	COG2267	carboxylic ester hydrolase activity
A4U42_RS18355	COG1686	Belongs to the peptidase S11 family
A4U42_RS18360	COG1349	DNA-binding transcription factor activity
A4U42_RS18365	COG2985	domain, Protein
A4U42_RS18365	COG0569	domain protein
A4U42_RS18385	COG0189	ligase activity
A4U42_RS18395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4U42_RS18400	COG3842	ATPase activity
A4U42_RS18405	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4U42_RS18410	COG1177	transmembrane transport
A4U42_RS18420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4U42_RS18430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U42_RS18435	COG4160	amino acid transport
A4U42_RS18440	COG4215	(ABC) transporter
A4U42_RS18445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U42_RS18450	COG1126	abc transporter atp-binding protein
A4U42_RS18455	COG0393	Putative heavy-metal-binding
A4U42_RS18460	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4U42_RS18465	COG0702	epimerase
A4U42_RS18470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4U42_RS18475	COG1151	hydroxylamine reductase activity
A4U42_RS18480	COG3593	DNA synthesis involved in DNA repair
A4U42_RS18485	COG1278	Cold shock
A4U42_RS18490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A4U42_RS18495	COG0542	response to heat
A4U42_RS18500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4U42_RS18505	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A4U42_RS18510	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A4U42_RS18515	COG4988	ABC transporter
A4U42_RS18520	COG0492	ferredoxin-NADP+ reductase activity
A4U42_RS18530	COG1674	ftsk spoiiie
A4U42_RS18530	COG3107	peptidoglycan biosynthetic process
A4U42_RS18535	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A4U42_RS18540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4U42_RS18545	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4U42_RS18550	COG3381	protein complex oligomerization
A4U42_RS18570	COG0583	DNA-binding transcription factor activity
A4U42_RS18575	COG0477	Major facilitator Superfamily
A4U42_RS18585	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4U42_RS18590	COG1882	Formate acetyltransferase
A4U42_RS18595	COG2116	formate transmembrane transporter activity
A4U42_RS18600	COG1944	ATP diphosphatase activity
A4U42_RS18605	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4U42_RS18610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4U42_RS18615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4U42_RS18620	COG0539	negative regulation of cytoplasmic translation
A4U42_RS18625	COG0776	regulation of translation
A4U42_RS18640	COG0140	phosphoribosyl-ATP diphosphatase activity
A4U42_RS18640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4U42_RS18645	COG0107	imidazoleglycerol-phosphate synthase activity
A4U42_RS18650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A4U42_RS18655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4U42_RS18660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4U42_RS18660	COG0131	Imidazoleglycerol-phosphate dehydratase
A4U42_RS18665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4U42_RS18670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4U42_RS18675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4U42_RS18680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4U42_RS18685	COG0840	transmembrane signaling receptor activity
A4U42_RS18700	COG3493	citrate carrier protein
A4U42_RS18705	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4U42_RS18710	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
A4U42_RS18715	COG3052	prosthetic group binding
A4U42_RS18730	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A4U42_RS18730	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
A4U42_RS18735	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A4U42_RS18740	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A4U42_RS18745	COG0531	amino acid
A4U42_RS18750	COG2925	Exonuclease
A4U42_RS18760	COG2926	Belongs to the UPF0265 family
A4U42_RS18770	COG0658	competence protein
A4U42_RS18770	COG2333	competence protein COMEC
A4U42_RS18775	COG1132	(ABC) transporter
A4U42_RS18780	COG1663	tetraacyldisaccharide 4'-kinase activity
A4U42_RS18785	COG2835	tetraacyldisaccharide 4'-kinase activity
A4U42_RS18790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A4U42_RS18800	COG3173	Aminoglycoside phosphotransferase
A4U42_RS18805	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4U42_RS18810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4U42_RS18815	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
A4U42_RS18820	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A4U42_RS18825	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A4U42_RS18845	COG2132	Multicopper oxidase
A4U42_RS18850	COG1733	regulation of RNA biosynthetic process
A4U42_RS18875	COG1349	DNA-binding transcription factor activity
A4U42_RS18885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4U42_RS18905	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4U42_RS18910	COG3381	protein complex oligomerization
A4U42_RS18920	COG2999	glutathione oxidoreductase activity
A4U42_RS18925	COG0477	Major facilitator Superfamily
A4U42_RS18930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4U42_RS18935	COG3132	Protein of unknown function, DUF480
A4U42_RS18945	COG0728	peptidoglycan biosynthetic process
A4U42_RS18950	COG0018	arginyl-trna synthetase
A4U42_RS18955	COG3102	Protein conserved in bacteria
A4U42_RS18960	COG3142	Participates in the control of copper homeostasis
A4U42_RS18970	COG0500	methyltransferase
A4U42_RS18975	COG2226	methyltransferase
A4U42_RS18980	COG3788	relative of glutathione S-transferase, MAPEG superfamily
A4U42_RS18985	COG1801	Protein of unknown function DUF72
A4U42_RS18990	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4U42_RS18995	COG0494	nUDIX hydrolase
A4U42_RS19010	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A4U42_RS19015	COG0632	four-way junction helicase activity
A4U42_RS19020	COG2255	four-way junction helicase activity
A4U42_RS19025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4U42_RS19030	COG1121	(ABC) transporter
A4U42_RS19035	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A4U42_RS19040	COG0739	heme binding
A4U42_RS19045	COG1560	Kdo2-lipid A biosynthetic process
A4U42_RS19060	COG0469	pyruvate kinase activity
A4U42_RS19065	COG1737	Transcriptional regulator
A4U42_RS19070	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4U42_RS19075	COG0800	Aldolase
A4U42_RS19080	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A4U42_RS19085	COG1770	oligopeptidase
A4U42_RS19100	COG1276	copper resistance
A4U42_RS19105	COG1528	Iron-storage protein
A4U42_RS19115	COG2204	response regulator
A4U42_RS19150	COG2261	transglycosylase associated protein
A4U42_RS19170	COG0444	Belongs to the ABC transporter superfamily
A4U42_RS19175	COG2718	Belongs to the UPF0229 family
A4U42_RS19180	COG2766	serine protein kinase
A4U42_RS19185	COG3713	MltA-interacting MipA family protein
A4U42_RS19190	COG0656	L-ascorbic acid biosynthetic process
A4U42_RS19205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4U42_RS19210	COG3139	Protein of unknown function (DUF1315)
A4U42_RS19215	COG1335	isochorismatase
A4U42_RS19220	COG0252	asparaginase activity
A4U42_RS19225	COG0616	signal peptide processing
A4U42_RS19230	COG0778	Nitroreductase
A4U42_RS19235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4U42_RS19250	COG2860	membrane
A4U42_RS19260	COG0788	formyltetrahydrofolate deformylase activity
A4U42_RS19265	COG3012	SEC-C Motif Domain Protein
A4U42_RS19270	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4U42_RS19275	COG0745	RESPONSE REGULATOR receiver
A4U42_RS19280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4U42_RS19290	COG1435	thymidine kinase activity
A4U42_RS19295	COG1012	belongs to the aldehyde dehydrogenase family
A4U42_RS19295	COG1454	alcohol dehydrogenase
A4U42_RS19300	COG2095	MarC family integral membrane protein
A4U42_RS19310	COG0601	transmembrane transport
A4U42_RS19315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U42_RS19320	COG0444	Belongs to the ABC transporter superfamily
A4U42_RS19335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4U42_RS19340	COG0840	transmembrane signaling receptor activity
A4U42_RS19345	COG2350	Protein conserved in bacteria
A4U42_RS19360	COG2917	probably involved in intracellular septation
A4U42_RS19375	COG3047	cAMP biosynthetic process
A4U42_RS19380	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A4U42_RS19385	COG0159	tryptophan synthase activity
A4U42_RS19390	COG0133	tryptophan synthase activity
A4U42_RS19395	COG0134	indole-3-glycerol-phosphate synthase activity
A4U42_RS19395	COG0135	phosphoribosylanthranilate isomerase activity
A4U42_RS19400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4U42_RS19405	COG0512	Glutamine amidotransferase of anthranilate synthase
A4U42_RS19420	COG0009	L-threonylcarbamoyladenylate synthase
A4U42_RS19425	COG1187	pseudouridine synthase activity
A4U42_RS19430	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A4U42_RS19435	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS19440	COG0616	signal peptide processing
A4U42_RS19465	COG0583	DNA-binding transcription factor activity
A4U42_RS19470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4U42_RS19480	COG4659	FMN binding
A4U42_RS19485	COG4658	electron transport chain
A4U42_RS19490	COG4656	Part of a membrane complex involved in electron transport
A4U42_RS19495	COG2878	Part of a membrane complex involved in electron transport
A4U42_RS19500	COG4657	Part of a membrane complex involved in electron transport
A4U42_RS19510	COG2160	L-arabinose isomerase activity
A4U42_RS19515	COG1069	ribulokinase activity
A4U42_RS19520	COG1879	ABC-type sugar transport system periplasmic component
A4U42_RS19525	COG1129	ABC transporter
A4U42_RS19530	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U42_RS19540	COG0673	inositol 2-dehydrogenase activity
A4U42_RS19545	COG0385	Bile acid
A4U42_RS19555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4U42_RS19560	COG5339	Protein conserved in bacteria
A4U42_RS19565	COG1482	cell wall glycoprotein biosynthetic process
A4U42_RS19570	COG0114	fumarate hydratase activity
A4U42_RS19580	COG2814	Major facilitator Superfamily
A4U42_RS19585	COG0583	DNA-binding transcription factor activity
A4U42_RS19590	COG1940	carbohydrate kinase activity
A4U42_RS19595	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4U42_RS19610	COG4221	oxidoreductase activity
A4U42_RS19615	COG2226	methyltransferase
A4U42_RS19620	COG1215	transferase activity, transferring glycosyl groups
A4U42_RS19640	COG2801	Transposase and inactivated derivatives
A4U42_RS19660	COG4305	rare lipoprotein A
A4U42_RS19680	COG2995	paraquat-inducible protein a
A4U42_RS19685	COG3008	intermembrane lipid transfer
A4U42_RS19685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4U42_RS19710	COG3158	transport of potassium into the cell
A4U42_RS19755	COG0702	epimerase
A4U42_RS19785	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A4U42_RS19790	COG0483	inositol monophosphate 1-phosphatase activity
A4U42_RS19795	COG0584	glycerophosphoryl diester phosphodiesterase
A4U42_RS19815	COG3842	ATPase activity
A4U42_RS19830	COG3479	Phenolic acid decarboxylase
A4U42_RS19840	COG0840	transmembrane signaling receptor activity
A4U42_RS19855	COG0840	transmembrane signaling receptor activity
A4U42_RS19865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4U42_RS19875	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A4U42_RS19880	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A4U42_RS19890	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A4U42_RS19895	COG2912	Transglutaminase-like superfamily
A4U42_RS19900	COG2890	protein-(glutamine-N5) methyltransferase activity
A4U42_RS19905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4U42_RS19910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A4U42_RS19915	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A4U42_RS19920	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4U42_RS19925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4U42_RS19935	COG0583	DNA-binding transcription factor activity
A4U42_RS19945	COG0193	aminoacyl-tRNA hydrolase activity
A4U42_RS19950	COG0012	GTP binding
A4U42_RS20015	COG0439	Biotin carboxylase
A4U42_RS20025	COG0513	Belongs to the DEAD box helicase family
A4U42_RS20050	COG3706	GGDEF domain
A4U42_RS20055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4U42_RS20060	COG1074	ATP-dependent DNA helicase activity
A4U42_RS20065	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A4U42_RS20090	COG5297	Belongs to the glycosyl hydrolase family 6
A4U42_RS20135	COG3210	domain, Protein
A4U42_RS20140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4U42_RS20145	COG2719	SpoVR family
A4U42_RS20150	COG2186	Transcriptional regulator
A4U42_RS20155	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A4U42_RS20160	COG2983	Belongs to the UPF0260 family
A4U42_RS20165	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4U42_RS20180	COG0850	regulation of cytokinetic process
A4U42_RS20185	COG2894	cell division
A4U42_RS20190	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A4U42_RS20195	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A4U42_RS20200	COG0318	PFAM AMP-dependent synthetase and ligase
A4U42_RS20205	COG3065	identical protein binding
A4U42_RS20215	COG1199	ATP-dependent helicase activity
A4U42_RS20220	COG0251	oxidation-reduction process
A4U42_RS20235	COG0494	nUDIX hydrolase
A4U42_RS20240	COG1760	l-serine dehydratase
A4U42_RS20245	COG0840	transmembrane signaling receptor activity
A4U42_RS20250	COG1253	flavin adenine dinucleotide binding
A4U42_RS20255	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U42_RS20255	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U42_RS20260	COG3715	PTS system
A4U42_RS20265	COG3716	PTS system mannose fructose sorbose family IID component
A4U42_RS20270	COG4811	Protein of unknown function (DUF986)
A4U42_RS20275	COG1971	Probably functions as a manganese efflux pump
A4U42_RS20280	COG2226	methyltransferase
A4U42_RS20290	COG3001	Fructosamine kinase
A4U42_RS20300	COG1917	Cupin 2, conserved barrel domain protein
A4U42_RS20305	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A4U42_RS20310	COG1028	Short-chain dehydrogenase reductase Sdr
A4U42_RS20320	COG1175	transmembrane transport
A4U42_RS20325	COG0395	ABC-type sugar transport system, permease component
A4U42_RS20330	COG3842	ATPase activity
A4U42_RS20340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A4U42_RS20345	COG0657	acetylesterase activity
A4U42_RS20345	COG2755	lipolytic protein G-D-S-L family
A4U42_RS20350	COG1988	membrane-bound metal-dependent
A4U42_RS20355	COG1823	symporter activity
A4U42_RS20360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4U42_RS20365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4U42_RS20380	COG0776	regulation of translation
A4U42_RS20385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4U42_RS20385	COG0072	phenylalanine-tRNA ligase activity
A4U42_RS20390	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4U42_RS20400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4U42_RS20405	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A4U42_RS20410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4U42_RS20425	COG0823	Involved in the tonB-independent uptake of proteins
A4U42_RS20430	COG0501	Belongs to the peptidase M48B family
A4U42_RS20440	COG0538	isocitrate dehydrogenase activity
A4U42_RS20455	COG0482	sulfurtransferase activity
A4U42_RS20460	COG2915	High frequency lysogenization protein hflD homolog
A4U42_RS20465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4U42_RS20480	COG2850	peptidyl-arginine hydroxylation
A4U42_RS20485	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4U42_RS20520	COG3210	domain, Protein
A4U42_RS20525	COG2831	hemolysin activation secretion protein
A4U42_RS20570	COG2161	toxin-antitoxin pair type II binding
A4U42_RS20585	COG2951	lytic endotransglycosylase activity
A4U42_RS20625	COG2197	response regulator
A4U42_RS20630	COG4585	Histidine kinase
A4U42_RS20680	COG4794	Type iii secretion
A4U42_RS20690	COG4792	protein secretion
A4U42_RS20705	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A4U42_RS20710	COG0840	transmembrane signaling receptor activity
A4U42_RS20715	COG0840	transmembrane signaling receptor activity
A4U42_RS20735	COG0626	cystathionine gamma-synthase activity
A4U42_RS20740	COG0765	amino acid transport
A4U42_RS20745	COG0765	amino acid transport
A4U42_RS20750	COG1126	abc transporter atp-binding protein
A4U42_RS20760	COG0561	phosphatase activity
A4U42_RS20765	COG2223	nitrite transmembrane transporter activity
A4U42_RS20770	COG0483	inositol monophosphate 1-phosphatase activity
A4U42_RS20775	COG1349	DNA-binding transcription factor activity
A4U42_RS20780	COG4774	siderophore transport
A4U42_RS20795	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4U42_RS20805	COG1012	belongs to the aldehyde dehydrogenase family
A4U42_RS20810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4U42_RS20820	COG3842	ATPase activity
A4U42_RS20875	COG1454	alcohol dehydrogenase
A4U42_RS20885	COG2181	nitrate reductase activity
A4U42_RS20890	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A4U42_RS20895	COG1140	nitrate reductase beta subunit
A4U42_RS20900	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A4U42_RS20905	COG0583	DNA-binding transcription factor activity
A4U42_RS20915	COG2223	nitrite transmembrane transporter activity
A4U42_RS20920	COG3850	Histidine kinase
A4U42_RS20925	COG2197	response regulator
A4U42_RS20940	COG0793	Belongs to the peptidase S41A family
A4U42_RS20945	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A4U42_RS20950	COG1956	GAF domain-containing protein
A4U42_RS20955	COG2995	paraquat-inducible protein a
A4U42_RS20960	COG3008	intermembrane lipid transfer
A4U42_RS20965	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A4U42_RS20965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4U42_RS20995	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4U42_RS21020	COG2175	clavaminate synthase activity