locus-tag	class	description
D083_RS00005	COG0840	transmembrane signaling receptor activity
D083_RS00015	COG0302	gtp cyclohydrolase
D083_RS00020	COG2311	Membrane
D083_RS00025	COG2949	membrane
D083_RS00030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D083_RS00035	COG2133	pyrroloquinoline quinone binding
D083_RS00040	COG0625	glutathione transferase activity
D083_RS00045	COG1464	Belongs to the NlpA lipoprotein family
D083_RS00050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D083_RS00055	COG2011	ABC-type metal ion transport system permease component
D083_RS00060	COG2267	carboxylic ester hydrolase activity
D083_RS00065	COG1686	Belongs to the peptidase S11 family
D083_RS00070	COG1349	DNA-binding transcription factor activity
D083_RS00075	COG2985	domain, Protein
D083_RS00075	COG0569	domain protein
D083_RS00100	COG0189	ligase activity
D083_RS00110	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D083_RS00115	COG3842	ATPase activity
D083_RS00120	COG1176	ABC-type spermidine putrescine transport system, permease component I
D083_RS00125	COG1177	transmembrane transport
D083_RS00135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D083_RS00145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D083_RS00150	COG4160	amino acid transport
D083_RS00155	COG4215	(ABC) transporter
D083_RS00160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D083_RS00165	COG1126	abc transporter atp-binding protein
D083_RS00170	COG0393	Putative heavy-metal-binding
D083_RS00175	COG3023	N-Acetylmuramoyl-L-alanine amidase
D083_RS00180	COG0702	epimerase
D083_RS00185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D083_RS00190	COG1151	hydroxylamine reductase activity
D083_RS00195	COG3593	DNA synthesis involved in DNA repair
D083_RS00200	COG1278	Cold shock
D083_RS00205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D083_RS00210	COG0542	response to heat
D083_RS00215	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D083_RS00220	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D083_RS00225	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D083_RS00230	COG4988	ABC transporter
D083_RS00235	COG0492	ferredoxin-NADP+ reductase activity
D083_RS00245	COG3107	peptidoglycan biosynthetic process
D083_RS00245	COG1674	ftsk spoiiie
D083_RS00250	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D083_RS00255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D083_RS00260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D083_RS00265	COG3381	protein complex oligomerization
D083_RS00285	COG0583	DNA-binding transcription factor activity
D083_RS00290	COG0477	Major facilitator Superfamily
D083_RS00300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D083_RS00305	COG1882	Formate acetyltransferase
D083_RS00310	COG2116	formate transmembrane transporter activity
D083_RS00315	COG1944	ATP diphosphatase activity
D083_RS00320	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D083_RS00325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D083_RS00330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D083_RS00335	COG0539	negative regulation of cytoplasmic translation
D083_RS00340	COG0776	regulation of translation
D083_RS00355	COG0140	phosphoribosyl-ATP diphosphatase activity
D083_RS00355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D083_RS00360	COG0107	imidazoleglycerol-phosphate synthase activity
D083_RS00365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D083_RS00370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D083_RS00375	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D083_RS00375	COG0131	Imidazoleglycerol-phosphate dehydratase
D083_RS00380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D083_RS00385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D083_RS00390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D083_RS00395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D083_RS00400	COG0840	transmembrane signaling receptor activity
D083_RS00415	COG3493	citrate carrier protein
D083_RS00420	COG0179	Fumarylacetoacetate (FAA) hydrolase
D083_RS00425	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
D083_RS00430	COG3052	prosthetic group binding
D083_RS00445	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D083_RS00445	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
D083_RS00450	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D083_RS00455	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D083_RS00465	COG0531	amino acid
D083_RS00470	COG2925	Exonuclease
D083_RS00480	COG2926	Belongs to the UPF0265 family
D083_RS00490	COG2333	competence protein COMEC
D083_RS00490	COG0658	competence protein
D083_RS00495	COG1132	(ABC) transporter
D083_RS00500	COG1663	tetraacyldisaccharide 4'-kinase activity
D083_RS00505	COG2835	tetraacyldisaccharide 4'-kinase activity
D083_RS00510	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D083_RS00520	COG3173	Aminoglycoside phosphotransferase
D083_RS00525	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D083_RS00530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D083_RS00535	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
D083_RS00540	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D083_RS00545	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D083_RS00565	COG2132	Multicopper oxidase
D083_RS00570	COG1733	regulation of RNA biosynthetic process
D083_RS00595	COG1349	DNA-binding transcription factor activity
D083_RS00605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D083_RS00625	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D083_RS00630	COG3381	protein complex oligomerization
D083_RS00640	COG2999	glutathione oxidoreductase activity
D083_RS00645	COG0477	Major facilitator Superfamily
D083_RS00650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D083_RS00655	COG3132	Protein of unknown function, DUF480
D083_RS00665	COG0728	peptidoglycan biosynthetic process
D083_RS00670	COG0018	arginyl-trna synthetase
D083_RS00675	COG3102	Protein conserved in bacteria
D083_RS00680	COG3142	Participates in the control of copper homeostasis
D083_RS00690	COG0500	methyltransferase
D083_RS00695	COG2226	methyltransferase
D083_RS00700	COG3788	relative of glutathione S-transferase, MAPEG superfamily
D083_RS00705	COG1801	Protein of unknown function DUF72
D083_RS00715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D083_RS00720	COG0494	nUDIX hydrolase
D083_RS00735	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D083_RS00740	COG0632	four-way junction helicase activity
D083_RS00745	COG2255	four-way junction helicase activity
D083_RS00750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D083_RS00755	COG1121	(ABC) transporter
D083_RS00760	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D083_RS00765	COG0739	heme binding
D083_RS00770	COG1560	Kdo2-lipid A biosynthetic process
D083_RS00785	COG0469	pyruvate kinase activity
D083_RS00790	COG1737	Transcriptional regulator
D083_RS00795	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D083_RS00800	COG0800	Aldolase
D083_RS00805	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D083_RS00810	COG1770	oligopeptidase
D083_RS00825	COG1276	copper resistance
D083_RS00830	COG1528	Iron-storage protein
D083_RS00840	COG2204	response regulator
D083_RS00875	COG2261	transglycosylase associated protein
D083_RS00895	COG0444	Belongs to the ABC transporter superfamily
D083_RS00900	COG2718	Belongs to the UPF0229 family
D083_RS00905	COG2766	serine protein kinase
D083_RS00910	COG3713	MltA-interacting MipA family protein
D083_RS00915	COG0656	L-ascorbic acid biosynthetic process
D083_RS00935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D083_RS00940	COG3139	Protein of unknown function (DUF1315)
D083_RS00945	COG1335	isochorismatase
D083_RS00950	COG0252	asparaginase activity
D083_RS00955	COG0616	signal peptide processing
D083_RS00960	COG0778	Nitroreductase
D083_RS00965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D083_RS00980	COG2860	membrane
D083_RS00990	COG0788	formyltetrahydrofolate deformylase activity
D083_RS00995	COG3012	SEC-C Motif Domain Protein
D083_RS01000	COG1752	Esterase of the alpha-beta hydrolase superfamily
D083_RS01005	COG0745	RESPONSE REGULATOR receiver
D083_RS01010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D083_RS01020	COG1435	thymidine kinase activity
D083_RS01025	COG1454	alcohol dehydrogenase
D083_RS01025	COG1012	belongs to the aldehyde dehydrogenase family
D083_RS01030	COG2095	MarC family integral membrane protein
D083_RS01040	COG0601	transmembrane transport
D083_RS01045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS01050	COG0444	Belongs to the ABC transporter superfamily
D083_RS01065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D083_RS01070	COG0840	transmembrane signaling receptor activity
D083_RS01075	COG2350	Protein conserved in bacteria
D083_RS01090	COG2917	probably involved in intracellular septation
D083_RS01100	COG0727	PFAM Uncharacterised protein family (UPF0153)
D083_RS01110	COG3047	cAMP biosynthetic process
D083_RS01115	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D083_RS01120	COG0159	tryptophan synthase activity
D083_RS01125	COG0133	tryptophan synthase activity
D083_RS01130	COG0135	phosphoribosylanthranilate isomerase activity
D083_RS01130	COG0134	indole-3-glycerol-phosphate synthase activity
D083_RS01135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D083_RS01140	COG0512	Glutamine amidotransferase of anthranilate synthase
D083_RS01155	COG0009	L-threonylcarbamoyladenylate synthase
D083_RS01160	COG1187	pseudouridine synthase activity
D083_RS01165	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D083_RS01170	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS01175	COG0616	signal peptide processing
D083_RS01200	COG0583	DNA-binding transcription factor activity
D083_RS01205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D083_RS01215	COG4659	FMN binding
D083_RS01220	COG4658	electron transport chain
D083_RS01225	COG4656	Part of a membrane complex involved in electron transport
D083_RS01230	COG2878	Part of a membrane complex involved in electron transport
D083_RS01235	COG4657	Part of a membrane complex involved in electron transport
D083_RS01245	COG2160	L-arabinose isomerase activity
D083_RS01250	COG1069	ribulokinase activity
D083_RS01255	COG1879	ABC-type sugar transport system periplasmic component
D083_RS01260	COG1129	ABC transporter
D083_RS01265	COG1172	Belongs to the binding-protein-dependent transport system permease family
D083_RS01275	COG0673	inositol 2-dehydrogenase activity
D083_RS01280	COG0385	Bile acid
D083_RS01290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D083_RS01295	COG5339	Protein conserved in bacteria
D083_RS01300	COG1482	cell wall glycoprotein biosynthetic process
D083_RS01305	COG0114	fumarate hydratase activity
D083_RS01315	COG2814	Major facilitator Superfamily
D083_RS01320	COG0583	DNA-binding transcription factor activity
D083_RS01325	COG1940	carbohydrate kinase activity
D083_RS01330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D083_RS01345	COG4221	oxidoreductase activity
D083_RS01350	COG2226	methyltransferase
D083_RS01355	COG1215	transferase activity, transferring glycosyl groups
D083_RS01400	COG4305	rare lipoprotein A
D083_RS01420	COG2995	paraquat-inducible protein a
D083_RS01425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D083_RS01425	COG3008	intermembrane lipid transfer
D083_RS01450	COG3158	transport of potassium into the cell
D083_RS01495	COG0702	epimerase
D083_RS01525	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D083_RS01530	COG0483	inositol monophosphate 1-phosphatase activity
D083_RS01535	COG0584	glycerophosphoryl diester phosphodiesterase
D083_RS01555	COG3842	ATPase activity
D083_RS01570	COG3479	Phenolic acid decarboxylase
D083_RS01580	COG0840	transmembrane signaling receptor activity
D083_RS01595	COG0840	transmembrane signaling receptor activity
D083_RS01605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D083_RS01615	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D083_RS01620	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D083_RS01630	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D083_RS01635	COG2912	Transglutaminase-like superfamily
D083_RS01640	COG2890	protein-(glutamine-N5) methyltransferase activity
D083_RS01645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D083_RS01650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D083_RS01655	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D083_RS01660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D083_RS01665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D083_RS01680	COG0583	DNA-binding transcription factor activity
D083_RS01690	COG0193	aminoacyl-tRNA hydrolase activity
D083_RS01695	COG0012	GTP binding
D083_RS01760	COG0439	Biotin carboxylase
D083_RS01770	COG0513	Belongs to the DEAD box helicase family
D083_RS01795	COG3706	GGDEF domain
D083_RS01800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D083_RS01805	COG1074	ATP-dependent DNA helicase activity
D083_RS01810	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D083_RS01835	COG5297	Belongs to the glycosyl hydrolase family 6
D083_RS01895	COG3210	domain, Protein
D083_RS01900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D083_RS01905	COG2719	SpoVR family
D083_RS01910	COG2186	Transcriptional regulator
D083_RS01915	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D083_RS01920	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D083_RS01925	COG2983	Belongs to the UPF0260 family
D083_RS01930	COG0179	Fumarylacetoacetate (FAA) hydrolase
D083_RS01945	COG0850	regulation of cytokinetic process
D083_RS01950	COG2894	cell division
D083_RS01955	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D083_RS01960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D083_RS01965	COG0318	PFAM AMP-dependent synthetase and ligase
D083_RS01970	COG3065	identical protein binding
D083_RS01980	COG1199	ATP-dependent helicase activity
D083_RS01985	COG0251	oxidation-reduction process
D083_RS02000	COG0494	nUDIX hydrolase
D083_RS02005	COG1760	l-serine dehydratase
D083_RS02010	COG0840	transmembrane signaling receptor activity
D083_RS02015	COG1253	flavin adenine dinucleotide binding
D083_RS02020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D083_RS02020	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D083_RS02025	COG3715	PTS system
D083_RS02030	COG3716	PTS system mannose fructose sorbose family IID component
D083_RS02035	COG4811	Protein of unknown function (DUF986)
D083_RS02040	COG1971	Probably functions as a manganese efflux pump
D083_RS02045	COG2226	methyltransferase
D083_RS02060	COG3001	Fructosamine kinase
D083_RS02070	COG1917	Cupin 2, conserved barrel domain protein
D083_RS02075	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D083_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS02090	COG1175	transmembrane transport
D083_RS02095	COG0395	ABC-type sugar transport system, permease component
D083_RS02100	COG3842	ATPase activity
D083_RS02110	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D083_RS02115	COG0657	acetylesterase activity
D083_RS02115	COG2755	lipolytic protein G-D-S-L family
D083_RS02120	COG1988	membrane-bound metal-dependent
D083_RS02125	COG1823	symporter activity
D083_RS02130	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D083_RS02135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D083_RS02150	COG0776	regulation of translation
D083_RS02155	COG0072	phenylalanine-tRNA ligase activity
D083_RS02155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D083_RS02160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D083_RS02170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D083_RS02175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D083_RS02180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D083_RS02195	COG0823	Involved in the tonB-independent uptake of proteins
D083_RS02200	COG0501	Belongs to the peptidase M48B family
D083_RS02210	COG0538	isocitrate dehydrogenase activity
D083_RS02225	COG0482	sulfurtransferase activity
D083_RS02230	COG2915	High frequency lysogenization protein hflD homolog
D083_RS02235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D083_RS02250	COG2850	peptidyl-arginine hydroxylation
D083_RS02255	COG2195	Cleaves the N-terminal amino acid of tripeptides
D083_RS02305	COG2831	hemolysin activation secretion protein
D083_RS02350	COG2161	toxin-antitoxin pair type II binding
D083_RS02365	COG2951	lytic endotransglycosylase activity
D083_RS02405	COG2197	response regulator
D083_RS02410	COG4585	Histidine kinase
D083_RS02460	COG4794	Type iii secretion
D083_RS02470	COG4792	protein secretion
D083_RS02485	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
D083_RS02490	COG0840	transmembrane signaling receptor activity
D083_RS02495	COG0840	transmembrane signaling receptor activity
D083_RS02515	COG0626	cystathionine gamma-synthase activity
D083_RS02520	COG0765	amino acid transport
D083_RS02525	COG0765	amino acid transport
D083_RS02530	COG1126	abc transporter atp-binding protein
D083_RS02540	COG0561	phosphatase activity
D083_RS02545	COG2223	nitrite transmembrane transporter activity
D083_RS02550	COG0483	inositol monophosphate 1-phosphatase activity
D083_RS02555	COG1349	DNA-binding transcription factor activity
D083_RS02560	COG4774	siderophore transport
D083_RS02575	COG1176	ABC-type spermidine putrescine transport system, permease component I
D083_RS02585	COG1012	belongs to the aldehyde dehydrogenase family
D083_RS02590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D083_RS02600	COG3842	ATPase activity
D083_RS02665	COG1454	alcohol dehydrogenase
D083_RS02675	COG2181	nitrate reductase activity
D083_RS02680	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D083_RS02685	COG1140	nitrate reductase beta subunit
D083_RS02690	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D083_RS02695	COG0583	DNA-binding transcription factor activity
D083_RS02705	COG2223	nitrite transmembrane transporter activity
D083_RS02710	COG3850	Histidine kinase
D083_RS02715	COG2197	response regulator
D083_RS02730	COG0793	Belongs to the peptidase S41A family
D083_RS02735	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D083_RS02740	COG1956	GAF domain-containing protein
D083_RS02745	COG2995	paraquat-inducible protein a
D083_RS02750	COG3008	intermembrane lipid transfer
D083_RS02755	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D083_RS02755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D083_RS02785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D083_RS02810	COG2175	clavaminate synthase activity
D083_RS02850	COG2840	Smr protein MutS2
D083_RS02860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D083_RS02915	COG0402	S-adenosylhomocysteine deaminase activity
D083_RS02925	COG0840	transmembrane signaling receptor activity
D083_RS02930	COG0840	transmembrane signaling receptor activity
D083_RS02940	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D083_RS02945	COG0038	chloride channel
D083_RS02955	COG4172	Belongs to the ABC transporter superfamily
D083_RS02960	COG0444	Belongs to the ABC transporter superfamily
D083_RS02965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS02970	COG0601	transmembrane transport
D083_RS02975	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D083_RS02980	COG0387	Pfam Sodium calcium exchanger
D083_RS02985	COG0659	secondary active sulfate transmembrane transporter activity
D083_RS02995	COG0745	RESPONSE REGULATOR receiver
D083_RS03000	COG2205	protein histidine kinase activity
D083_RS03010	COG3591	Belongs to the peptidase S1B family
D083_RS03015	COG1620	l-lactate permease
D083_RS03020	COG0247	lactate metabolic process
D083_RS03025	COG1139	Iron-sulfur cluster binding protein
D083_RS03030	COG1556	Lactate utilization protein
D083_RS03035	COG1643	Atp-dependent helicase
D083_RS03040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D083_RS03050	COG2911	Protein conserved in bacteria
D083_RS03055	COG0840	transmembrane signaling receptor activity
D083_RS03060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D083_RS03070	COG0840	transmembrane signaling receptor activity
D083_RS03090	COG0037	tRNA processing
D083_RS03100	COG0598	Magnesium transport protein CorA
D083_RS03105	COG4166	transmembrane transport
D083_RS03110	COG2866	Carboxypeptidase
D083_RS03115	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D083_RS03120	COG0477	Major facilitator Superfamily
D083_RS03150	COG1902	pentaerythritol trinitrate reductase activity
D083_RS03155	COG0583	DNA-binding transcription factor activity
D083_RS03170	COG2271	Major facilitator Superfamily
D083_RS03175	COG3768	UPF0283 membrane protein
D083_RS03180	COG3106	COG3106 Predicted ATPase
D083_RS03185	COG1983	PspC domain protein
D083_RS03195	COG1842	Phage shock protein A
D083_RS03200	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D083_RS03210	COG4166	transmembrane transport
D083_RS03215	COG4168	peptide transport system, permease
D083_RS03225	COG4172	Belongs to the ABC transporter superfamily
D083_RS03245	COG0243	molybdopterin cofactor binding
D083_RS03250	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
D083_RS03255	COG4989	oxidoreductase activity
D083_RS03260	COG1966	Carbon starvation protein
D083_RS03280	COG0023	Translation Initiation Factor
D083_RS03290	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D083_RS03295	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D083_RS03300	COG0671	phosphoesterase, PA-phosphatase related
D083_RS03320	COG0625	glutathione transferase activity
D083_RS03325	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D083_RS03335	COG0259	pyridoxamine-phosphate oxidase activity
D083_RS03340	COG3895	Periplasmic Protein
D083_RS03345	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D083_RS03360	COG3313	Fe-S protein
D083_RS03365	COG0346	lactoylglutathione lyase activity
D083_RS03370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D083_RS03375	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D083_RS03380	COG0791	NLP P60 protein
D083_RS03390	COG1609	Transcriptional regulator
D083_RS03395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D083_RS03400	COG0307	riboflavin synthase, alpha
D083_RS03405	COG0534	Mate efflux family protein
D083_RS03420	COG2382	esterase
D083_RS03450	COG4238	major outer membrane lipoprotein
D083_RS03455	COG1376	ErfK ybiS ycfS ynhG family protein
D083_RS03455	COG1388	LysM domain
D083_RS03460	COG2166	iron-sulfur cluster assembly
D083_RS03465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D083_RS03470	COG0719	Fe-S assembly protein
D083_RS03475	COG0396	ATPase activity
D083_RS03480	COG0719	Fe-S assembly protein
D083_RS03485	COG0316	Belongs to the HesB IscA family
D083_RS03495	COG2050	protein possibly involved in aromatic compounds catabolism
D083_RS03500	COG0277	FAD linked oxidase domain protein
D083_RS03500	COG0247	lactate metabolic process
D083_RS03505	COG0628	permease
D083_RS03515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D083_RS03515	COG0574	Belongs to the PEP-utilizing enzyme family
D083_RS03520	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D083_RS03530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D083_RS03535	COG3130	regulation of translation
D083_RS03540	COG3009	Protein conserved in bacteria
D083_RS03545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D083_RS03545	COG3008	intermembrane lipid transfer
D083_RS03550	COG2995	paraquat-inducible protein a
D083_RS03555	COG0488	(ABC) transporter
D083_RS03560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D083_RS03560	COG0116	Belongs to the methyltransferase superfamily
D083_RS03565	COG3217	Mosc domain protein beta barrel domain protein
D083_RS03565	COG0633	Ferredoxin
D083_RS03575	COG0167	dihydroorotate dehydrogenase activity
D083_RS03580	COG0431	NADPH-dependent FMN reductase
D083_RS03585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D083_RS03590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D083_RS03595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D083_RS03600	COG1116	anion transmembrane transporter activity
D083_RS03605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D083_RS03615	COG0308	aminopeptidase N
D083_RS03620	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D083_RS03625	COG0017	Asparaginyl-tRNA synthetase
D083_RS03645	COG1448	Aminotransferase
D083_RS03650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D083_RS03655	COG3108	Peptidase M15
D083_RS03660	COG2989	Protein conserved in bacteria
D083_RS03665	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D083_RS03675	COG0095	Lipoate-protein ligase
D083_RS03680	COG0791	NLP P60 protein
D083_RS03685	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
D083_RS03690	COG0386	Belongs to the glutathione peroxidase family
D083_RS03695	COG4139	cobalamin transport
D083_RS03715	COG4591	ABC-type transport system involved in lipoprotein release permease component
D083_RS03720	COG1136	(ABC) transporter
D083_RS03725	COG4591	ABC-type transport system involved in lipoprotein release permease component
D083_RS03730	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D083_RS03735	COG2200	EAL domain
D083_RS03740	COG0443	Heat shock 70 kDa protein
D083_RS03755	COG2271	Major facilitator Superfamily
D083_RS03760	COG1609	Transcriptional regulator
D083_RS03765	COG3134	Outer membrane lipoprotein
D083_RS03770	COG1252	NADH dehydrogenase
D083_RS03780	COG1472	Belongs to the glycosyl hydrolase 3 family
D083_RS03790	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
D083_RS03795	COG5633	Lipoprotein
D083_RS03800	COG0537	adenosine 5'-monophosphoramidase activity
D083_RS03810	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D083_RS03815	COG1263	PTS System
D083_RS03815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D083_RS03820	COG0084	hydrolase, TatD family'
D083_RS03825	COG0470	DNA polymerase III
D083_RS03830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D083_RS03835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D083_RS03840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D083_RS03845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D083_RS03850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D083_RS03855	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS03865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D083_RS03870	COG0416	fatty acid biosynthetic process
D083_RS03875	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D083_RS03880	COG1399	metal-binding, possibly nucleic acid-binding protein
D083_RS03885	COG0424	maF-like protein
D083_RS03890	COG0564	pseudouridine synthase activity
D083_RS03895	COG1530	ribonuclease E activity
D083_RS03905	COG0418	dihydroorotase activity
D083_RS03920	COG3038	cytochrome b561
D083_RS03930	COG1054	Belongs to the UPF0176 family
D083_RS03935	COG1902	pentaerythritol trinitrate reductase activity
D083_RS03940	COG1560	Kdo2-lipid A biosynthetic process
D083_RS03945	COG2814	Major facilitator Superfamily
D083_RS03950	COG2943	transferase activity, transferring hexosyl groups
D083_RS03955	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D083_RS03970	COG0840	transmembrane signaling receptor activity
D083_RS03990	COG1067	ATP-dependent peptidase activity
D083_RS03995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D083_RS04005	COG1012	belongs to the aldehyde dehydrogenase family
D083_RS04030	COG1702	phosphate starvation-inducible protein PhoH
D083_RS04045	COG1191	sigma factor activity
D083_RS04060	COG0673	inositol 2-dehydrogenase activity
D083_RS04075	COG0500	methyltransferase
D083_RS04085	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D083_RS04100	COG1677	Flagellar hook-basal body complex protein FliE
D083_RS04115	COG1317	bacterial-type flagellum organization
D083_RS04120	COG1157	protein secretion by the type III secretion system
D083_RS04135	COG1580	Controls the rotational direction of flagella during chemotaxis
D083_RS04170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D083_RS04175	COG1256	bacterial-type flagellum assembly
D083_RS04185	COG1706	bacterial-type flagellum-dependent cell motility
D083_RS04190	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D083_RS04200	COG4787	bacterial-type flagellum-dependent cell motility
D083_RS04205	COG1749	Flagellar hook protein flgE
D083_RS04210	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D083_RS04215	COG1558	bacterial-type flagellum-dependent cell motility
D083_RS04220	COG1815	bacterial-type flagellum-dependent cell motility
D083_RS04230	COG2747	anti-sigma28 factor FlgM
D083_RS04245	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D083_RS04250	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D083_RS04255	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D083_RS04260	COG0745	RESPONSE REGULATOR receiver
D083_RS04265	COG2201	protein-glutamate methylesterase activity
D083_RS04270	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D083_RS04275	COG0840	transmembrane signaling receptor activity
D083_RS04280	COG0835	chemotaxis
D083_RS04285	COG0643	Histidine kinase
D083_RS04285	COG2198	Histidine kinase
D083_RS04290	COG1360	Flagellar Motor Protein
D083_RS04310	COG1979	alcohol dehydrogenase
D083_RS04315	COG0840	transmembrane signaling receptor activity
D083_RS04330	COG0534	Mate efflux family protein
D083_RS04340	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D083_RS04345	COG4733	cellulase activity
D083_RS04390	COG0534	Mate efflux family protein
D083_RS04410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D083_RS04445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D083_RS04445	COG3321	synthase
D083_RS04445	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS04445	COG4221	oxidoreductase activity
D083_RS04460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D083_RS04465	COG0322	excinuclease ABC activity
D083_RS04470	COG2197	response regulator
D083_RS04485	COG1113	amino acid transport
D083_RS04500	COG1819	glycosyl
D083_RS04510	COG0840	transmembrane signaling receptor activity
D083_RS04515	COG1619	proteins homologs of microcin C7 resistance protein MccF
D083_RS04520	COG0583	DNA-binding transcription factor activity
D083_RS04525	COG0436	Aminotransferase
D083_RS04545	COG1648	precorrin-2 dehydrogenase activity
D083_RS04545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D083_RS04550	COG0243	molybdopterin cofactor binding
D083_RS04555	COG2146	nitrite reductase [NAD(P)H] activity
D083_RS04555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D083_RS04560	COG1116	anion transmembrane transporter activity
D083_RS04570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D083_RS04575	COG3707	response regulator
D083_RS04585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D083_RS04590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D083_RS04600	COG2814	Major facilitator Superfamily
D083_RS04605	COG0657	acetylesterase activity
D083_RS04610	COG3058	Necessary for formate dehydrogenase activity
D083_RS04615	COG2271	Major facilitator Superfamily
D083_RS04625	COG2864	formate dehydrogenase
D083_RS04630	COG0437	4 iron, 4 sulfur cluster binding
D083_RS04635	COG3383	formate dehydrogenase (NAD+) activity
D083_RS04635	COG0243	molybdopterin cofactor binding
D083_RS04640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D083_RS04645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D083_RS04645	COG0519	Catalyzes the synthesis of GMP from XMP
D083_RS04655	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D083_RS04665	COG0309	Hydrogenase expression formation protein (HypE)
D083_RS04670	COG0409	Hydrogenase expression formation protein
D083_RS04675	COG0298	carbon dioxide binding
D083_RS04680	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D083_RS04690	COG1773	rubredoxin
D083_RS04695	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D083_RS04700	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D083_RS04705	COG5557	Pfam Polysulphide reductase, NrfD
D083_RS04710	COG0437	4 iron, 4 sulfur cluster binding
D083_RS04715	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D083_RS04720	COG0488	(ABC) transporter
D083_RS04725	COG0384	phenazine biosynthesis protein PhzF
D083_RS04735	COG1007	ATP synthesis coupled electron transport
D083_RS04740	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D083_RS04745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D083_RS04750	COG0713	ATP synthesis coupled electron transport
D083_RS04755	COG0839	Belongs to the complex I subunit 6 family
D083_RS04760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D083_RS04765	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D083_RS04775	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D083_RS04785	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D083_RS04785	COG0649	NAD binding
D083_RS04795	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D083_RS04800	COG0583	DNA-binding transcription factor activity
D083_RS04805	COG0436	Aminotransferase
D083_RS04810	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D083_RS04815	COG0490	domain, Protein
D083_RS04815	COG0471	metal ion transport
D083_RS04820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D083_RS04825	COG3013	Belongs to the UPF0304 family
D083_RS04830	COG3092	negative regulation of chromosome organization
D083_RS04840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D083_RS04845	COG0857	belongs to the CobB CobQ family
D083_RS04845	COG0280	phosphate acetyltransferase
D083_RS04850	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D083_RS04855	COG0622	Phosphoesterase
D083_RS04860	COG0625	glutathione transferase activity
D083_RS04865	COG1090	epimerase
D083_RS04880	COG4215	(ABC) transporter
D083_RS04885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D083_RS04890	COG0163	prenyltransferase activity
D083_RS04895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D083_RS04900	COG1286	toxin biosynthetic process
D083_RS04905	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D083_RS04910	COG0285	dihydrofolate synthase activity
D083_RS04915	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D083_RS04925	COG0586	Pfam SNARE associated Golgi protein
D083_RS04935	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D083_RS04940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D083_RS04950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D083_RS04955	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D083_RS04955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D083_RS05000	COG3101	peptidyl-lysine hydroxylation
D083_RS05005	COG0730	response to heat
D083_RS05010	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D083_RS05015	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D083_RS05020	COG2890	protein-(glutamine-N5) methyltransferase activity
D083_RS05025	COG2840	Smr protein MutS2
D083_RS05030	COG2062	phosphohistidine phosphatase, SixA
D083_RS05035	COG1024	Enoyl-CoA hydratase
D083_RS05035	COG1250	3-hydroxyacyl-CoA dehydrogenase
D083_RS05040	COG0183	Belongs to the thiolase family
D083_RS05045	COG3691	Protein conserved in bacteria
D083_RS05050	COG2067	long-chain fatty acid transport protein
D083_RS05055	COG0579	oxidoreductase
D083_RS05075	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D083_RS05090	COG4592	Periplasmic binding protein
D083_RS05100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D083_RS05105	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D083_RS05110	COG1120	ATPase activity
D083_RS05135	COG2382	esterase
D083_RS05140	COG4774	siderophore transport
D083_RS05145	COG1169	isochorismate synthase
D083_RS05150	COG1021	2,3-dihydroxybenzoate-AMP ligase
D083_RS05155	COG3433	isochorismatase activity
D083_RS05155	COG1535	isochorismatase
D083_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS05165	COG2050	protein possibly involved in aromatic compounds catabolism
D083_RS05175	COG1902	pentaerythritol trinitrate reductase activity
D083_RS05185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D083_RS05240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D083_RS05245	COG1450	Type ii and iii secretion system protein
D083_RS05250	COG3031	protein transport across the cell outer membrane
D083_RS05255	COG3266	domain, Protein
D083_RS05265	COG0436	Aminotransferase
D083_RS05270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D083_RS05275	COG3264	Mechanosensitive ion channel
D083_RS05275	COG1511	domain protein
D083_RS05290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D083_RS05320	COG2850	peptidyl-arginine hydroxylation
D083_RS05345	COG0583	DNA-binding transcription factor activity
D083_RS05350	COG1126	abc transporter atp-binding protein
D083_RS05355	COG0765	amino acid transport
D083_RS05370	COG0583	DNA-binding transcription factor activity
D083_RS05375	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D083_RS05380	COG1301	dicarboxylic acid transport
D083_RS05385	COG0436	Aminotransferase
D083_RS05390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D083_RS05410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D083_RS05410	COG1263	PTS System
D083_RS05415	COG1874	Beta-galactosidase
D083_RS05425	COG3833	ABC-type maltose transport systems, permease component
D083_RS05430	COG1175	transmembrane transport
D083_RS05435	COG2182	Extracellular solute-binding protein
D083_RS05445	COG1473	amidohydrolase
D083_RS05455	COG5297	Belongs to the glycosyl hydrolase family 6
D083_RS05465	COG4948	Mandelate Racemase Muconate Lactonizing
D083_RS05470	COG1904	glucuronate isomerase
D083_RS05475	COG2211	Major facilitator Superfamily
D083_RS05480	COG0246	Mannitol dehydrogenase
D083_RS05485	COG1802	Transcriptional regulator
D083_RS05490	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D083_RS05495	COG2986	histidine ammonia-lyase
D083_RS05540	COG3290	protein histidine kinase activity
D083_RS05545	COG4565	transcriptional regulatory protein
D083_RS05550	COG2986	histidine ammonia-lyase
D083_RS05580	COG0402	S-adenosylhomocysteine deaminase activity
D083_RS05600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D083_RS05605	COG2501	S4 domain
D083_RS05610	COG0215	cysteine-tRNA ligase activity
D083_RS05620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D083_RS05625	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D083_RS05630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D083_RS05635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D083_RS05640	COG0814	amino acid
D083_RS05645	COG1760	l-serine dehydratase
D083_RS05660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D083_RS05665	COG0581	inorganic phosphate transmembrane transporter activity
D083_RS05670	COG0573	inorganic phosphate transmembrane transporter activity
D083_RS05675	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D083_RS05690	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D083_RS05695	COG0589	response to stress
D083_RS05715	COG0670	Belongs to the BI1 family
D083_RS05720	COG2920	part of a sulfur-relay system
D083_RS05725	COG1254	Belongs to the acylphosphatase family
D083_RS05730	COG3785	DNA binding
D083_RS05735	COG1832	CoA-binding protein
D083_RS05745	COG1803	Methylglyoxal synthase
D083_RS05750	COG0210	DNA helicase
D083_RS05755	COG3304	Inner membrane component domain
D083_RS05760	COG1289	transmembrane transporter activity
D083_RS05765	COG3070	regulator of competence-specific genes
D083_RS05770	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
D083_RS05775	COG2885	chlorophyll binding
D083_RS05775	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D083_RS05785	COG0667	Aldo Keto reductase
D083_RS05790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D083_RS05795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D083_RS05800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D083_RS05805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D083_RS05810	COG0477	Major facilitator Superfamily
D083_RS05815	COG2205	protein histidine kinase activity
D083_RS05820	COG0745	RESPONSE REGULATOR receiver
D083_RS05825	COG0435	Glutathione S-transferase
D083_RS05830	COG0826	peptidase U32
D083_RS05835	COG3223	Belongs to the PsiE family
D083_RS05840	COG3622	Belongs to the hyi family
D083_RS05845	COG2211	Major facilitator Superfamily
D083_RS05855	COG0673	inositol 2-dehydrogenase activity
D083_RS05870	COG0351	phosphomethylpyrimidine kinase
D083_RS05875	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D083_RS05880	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D083_RS05885	COG2814	Major facilitator Superfamily
D083_RS05895	COG2192	nodulation
D083_RS05905	COG0583	DNA-binding transcription factor activity
D083_RS05910	COG2814	Major facilitator Superfamily
D083_RS05915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D083_RS05945	COG1733	regulation of RNA biosynthetic process
D083_RS05950	COG0604	alcohol dehydrogenase
D083_RS05950	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS05950	COG3321	synthase
D083_RS05985	COG1309	transcriptional regulator
D083_RS05990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D083_RS05990	COG0519	Catalyzes the synthesis of GMP from XMP
D083_RS05995	COG0516	GMP reductase activity
D083_RS05995	COG0517	IMP dehydrogenase activity
D083_RS06000	COG1570	exodeoxyribonuclease VII activity
D083_RS06020	COG1160	GTP binding
D083_RS06025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D083_RS06030	COG2976	Protein conserved in bacteria
D083_RS06035	COG0124	histidyl-tRNA synthetase
D083_RS06040	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D083_RS06045	COG1426	Protein conserved in bacteria
D083_RS06055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D083_RS06060	COG0105	UTP biosynthetic process
D083_RS06065	COG2897	thiosulfate sulfurtransferase activity
D083_RS06075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D083_RS06080	COG2975	iron-sulfur cluster assembly
D083_RS06085	COG0633	Ferredoxin
D083_RS06090	COG0443	Heat shock 70 kDa protein
D083_RS06095	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D083_RS06100	COG0316	Belongs to the HesB IscA family
D083_RS06105	COG0822	iron-sulfur transferase activity
D083_RS06115	COG1959	2 iron, 2 sulfur cluster binding
D083_RS06120	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D083_RS06125	COG0483	inositol monophosphate 1-phosphatase activity
D083_RS06135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D083_RS06140	COG1120	ATPase activity
D083_RS06150	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D083_RS06155	COG3683	transport system, periplasmic component
D083_RS06160	COG2814	Major facilitator Superfamily
D083_RS06165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D083_RS06170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D083_RS06170	COG1017	nitric oxide dioxygenase activity
D083_RS06175	COG3866	Pectate lyase
D083_RS06195	COG4677	pectinesterase activity
D083_RS06200	COG0347	Belongs to the P(II) protein family
D083_RS06205	COG2204	response regulator
D083_RS06210	COG3170	Tfp pilus assembly protein FimV
D083_RS06215	COG2205	protein histidine kinase activity
D083_RS06220	COG0047	phosphoribosylformylglycinamidine synthase activity
D083_RS06220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D083_RS06225	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D083_RS06235	COG0560	Phosphoserine phosphatase
D083_RS06240	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D083_RS06255	COG2274	protein secretion by the type I secretion system
D083_RS06270	COG2200	EAL domain
D083_RS06275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D083_RS06280	COG0736	holo-[acyl-carrier-protein] synthase activity
D083_RS06285	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D083_RS06290	COG1381	Involved in DNA repair and RecF pathway recombination
D083_RS06295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D083_RS06300	COG0571	ribonuclease III activity
D083_RS06310	COG0481	GTPase activity
D083_RS06315	COG3086	response to oxidative stress
D083_RS06320	COG3026	antisigma factor binding
D083_RS06335	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D083_RS06340	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D083_RS06345	COG0513	Belongs to the DEAD box helicase family
D083_RS06350	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
D083_RS06355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D083_RS06370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D083_RS06400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D083_RS06405	COG4208	sulfate ABC transporter
D083_RS06410	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D083_RS06415	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D083_RS06420	COG3835	regulator
D083_RS06430	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D083_RS06435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D083_RS06440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D083_RS06460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D083_RS06465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D083_RS06470	COG1120	ATPase activity
D083_RS06475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D083_RS06480	COG1643	Atp-dependent helicase
D083_RS06485	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D083_RS06490	COG1489	DNA binding
D083_RS06495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D083_RS06500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D083_RS06505	COG0617	tRNA 3'-terminal CCA addition
D083_RS06510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D083_RS06515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D083_RS06520	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D083_RS06525	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D083_RS06530	COG0842	Transport permease protein
D083_RS06535	COG1131	(ABC) transporter
D083_RS06540	COG0288	reversible hydration of carbon dioxide
D083_RS06545	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D083_RS06560	COG3842	ATPase activity
D083_RS06580	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D083_RS06585	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D083_RS06595	COG1780	Probably involved in ribonucleotide reductase function
D083_RS06600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D083_RS06605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D083_RS06620	COG0328	RNA-DNA hybrid ribonuclease activity
D083_RS06625	COG2226	methyltransferase
D083_RS06630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D083_RS06635	COG0741	lytic transglycosylase activity
D083_RS06635	COG1388	LysM domain
D083_RS06640	COG3021	interspecies interaction between organisms
D083_RS06675	COG0542	response to heat
D083_RS06680	COG1496	oxidoreductase activity
D083_RS06685	COG0564	pseudouridine synthase activity
D083_RS06690	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D083_RS06695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D083_RS06700	COG0077	Prephenate dehydratase
D083_RS06700	COG1605	Chorismate mutase
D083_RS06705	COG1605	Chorismate mutase
D083_RS06705	COG0287	Prephenate dehydrogenase
D083_RS06710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D083_RS06725	COG0335	large ribosomal subunit rRNA binding
D083_RS06730	COG0336	Belongs to the RNA methyltransferase TrmD family
D083_RS06735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D083_RS06740	COG0228	four-way junction DNA binding
D083_RS06745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D083_RS06750	COG4137	Cytochrome C assembly protein
D083_RS06755	COG1854	S-ribosylhomocysteine lyase activity
D083_RS06760	COG2918	glutathione biosynthetic process
D083_RS06765	COG1238	metal cluster binding
D083_RS06770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D083_RS06795	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D083_RS06800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D083_RS06805	COG2137	regulation of response to DNA damage stimulus
D083_RS06810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D083_RS06825	COG3038	cytochrome b561
D083_RS06830	COG1280	lysine exporter protein (LysE YggA)
D083_RS06860	COG1879	ABC-type sugar transport system periplasmic component
D083_RS06865	COG1129	ABC transporter
D083_RS06870	COG1172	Belongs to the binding-protein-dependent transport system permease family
D083_RS06875	COG1172	Belongs to the binding-protein-dependent transport system permease family
D083_RS06880	COG0688	phosphatidylethanolamine metabolic process
D083_RS06895	COG2207	Transcriptional regulator
D083_RS06905	COG0523	cobalamin synthesis protein
D083_RS06910	COG2879	small protein
D083_RS06915	COG1966	Carbon starvation protein
D083_RS06925	COG3275	phosphorelay sensor kinase activity
D083_RS06945	COG0601	transmembrane transport
D083_RS06950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS06960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D083_RS06970	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D083_RS06995	COG0583	DNA-binding transcription factor activity
D083_RS07005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D083_RS07010	COG1696	Membrane protein involved in D-alanine export
D083_RS07050	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D083_RS07055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D083_RS07065	COG2199	diguanylate cyclase activity
D083_RS07075	COG1073	alpha beta
D083_RS07080	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D083_RS07090	COG2195	Cleaves the N-terminal amino acid of tripeptides
D083_RS07095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D083_RS07100	COG3034	peptidoglycan biosynthetic process
D083_RS07105	COG0121	glutamine amidotransferase
D083_RS07110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D083_RS07115	COG1960	acyl-CoA dehydrogenase activity
D083_RS07120	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D083_RS07130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D083_RS07135	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D083_RS07140	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
D083_RS07145	COG0235	Class ii aldolase
D083_RS07150	COG0436	Aminotransferase
D083_RS07155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D083_RS07165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D083_RS07175	COG0765	amino acid transport
D083_RS07220	COG3550	peptidyl-serine autophosphorylation
D083_RS07240	COG1953	Uracil, thiamine, allantoin
D083_RS07245	COG4175	Glycine betaine
D083_RS07250	COG4176	ABC-type proline glycine betaine transport system permease component
D083_RS07255	COG2113	Glycine betaine
D083_RS07260	COG2814	Major facilitator Superfamily
D083_RS07265	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D083_RS07275	COG1846	Transcriptional regulator
D083_RS07280	COG1566	PFAM secretion protein HlyD family protein
D083_RS07285	COG2814	Major facilitator Superfamily
D083_RS07290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D083_RS07295	COG3118	belongs to the thioredoxin family
D083_RS07300	COG3148	PFAM DTW domain containing protein
D083_RS07305	COG0045	succinate-CoA ligase (ADP-forming) activity
D083_RS07305	COG1042	CoA-binding domain protein
D083_RS07305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D083_RS07310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D083_RS07315	COG5544	Lipoprotein
D083_RS07320	COG0477	Major facilitator Superfamily
D083_RS07365	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D083_RS07370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D083_RS07375	COG2011	ABC-type metal ion transport system permease component
D083_RS07380	COG1464	Belongs to the NlpA lipoprotein family
D083_RS07390	COG1720	tRNA m6t6A37 methyltransferase activity
D083_RS07395	COG0442	prolyl-tRNA aminoacylation
D083_RS07405	COG1388	LysM domain
D083_RS07405	COG4942	peptidase
D083_RS07410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D083_RS07415	COG0585	pseudouridine synthase activity
D083_RS07420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D083_RS07425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D083_RS07430	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D083_RS07440	COG0529	Catalyzes the synthesis of activated sulfate
D083_RS07445	COG2895	sulfate adenylyltransferase (ATP) activity
D083_RS07455	COG1648	precorrin-2 dehydrogenase activity
D083_RS07455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D083_RS07460	COG0175	sulfate reduction
D083_RS07465	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D083_RS07470	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D083_RS07475	COG0720	synthase
D083_RS07480	COG0602	queuosine metabolic process
D083_RS07485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D083_RS07490	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D083_RS07500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D083_RS07510	COG0148	phosphopyruvate hydratase activity
D083_RS07515	COG0504	CTP synthase activity
D083_RS07520	COG3956	TIGRFAM MazG family protein
D083_RS07525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D083_RS07530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D083_RS07540	COG1929	Belongs to the glycerate kinase type-1 family
D083_RS07545	COG2084	Dehydrogenase
D083_RS07555	COG4948	Mandelate Racemase Muconate Lactonizing
D083_RS07560	COG4948	Mandelate Racemase Muconate Lactonizing
D083_RS07565	COG2271	Major facilitator Superfamily
D083_RS07570	COG2721	sulfolactate sulfo-lyase activity
D083_RS07575	COG0840	transmembrane signaling receptor activity
D083_RS07595	COG3530	Putative quorum-sensing-regulated virulence factor
D083_RS07600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D083_RS07605	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D083_RS07605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D083_RS07610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D083_RS07615	COG3025	triphosphatase activity
D083_RS07620	COG4991	sh3 domain protein
D083_RS07625	COG0617	tRNA 3'-terminal CCA addition
D083_RS07630	COG1968	undecaprenyl-diphosphatase activity
D083_RS07635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D083_RS07640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D083_RS07650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D083_RS07655	COG2105	PFAM AIG2 family protein
D083_RS07665	COG0729	surface antigen
D083_RS07670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D083_RS07675	COG1253	flavin adenine dinucleotide binding
D083_RS07685	COG1218	3'(2'),5'-bisphosphate nucleotidase
D083_RS07690	COG0737	Belongs to the 5'-nucleotidase family
D083_RS07695	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
D083_RS07705	COG0545	Peptidyl-prolyl cis-trans isomerase
D083_RS07710	COG3061	Opacity-associated protein A
D083_RS07720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D083_RS07725	COG1609	Transcriptional regulator
D083_RS07730	COG0840	transmembrane signaling receptor activity
D083_RS07740	COG2271	Major facilitator Superfamily
D083_RS07750	COG0359	binds to the 23S rRNA
D083_RS07755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D083_RS07760	COG2965	DNA replication, synthesis of RNA primer
D083_RS07765	COG0360	Binds together with S18 to 16S ribosomal RNA
D083_RS07770	COG1073	alpha beta
D083_RS07790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D083_RS07795	COG0557	exoribonuclease II activity
D083_RS07800	COG1959	2 iron, 2 sulfur cluster binding
D083_RS07815	COG0402	S-adenosylhomocysteine deaminase activity
D083_RS07820	COG2805	Type II/IV secretion system protein
D083_RS07825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D083_RS07830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D083_RS07835	COG0762	integral membrane protein
D083_RS07840	COG1872	DUF167
D083_RS07845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D083_RS07850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D083_RS07860	COG2153	protein acetylation
D083_RS07865	COG0477	Major facilitator Superfamily
D083_RS07870	COG0318	PFAM AMP-dependent synthetase and ligase
D083_RS07870	COG0204	Acyl-transferase
D083_RS07875	COG2723	6-phospho-beta-galactosidase activity
D083_RS07880	COG2723	6-phospho-beta-galactosidase activity
D083_RS07885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D083_RS07885	COG1263	PTS System
D083_RS07885	COG2190	(PTS) system
D083_RS07890	COG3711	transcriptional antiterminator
D083_RS07905	COG1609	Transcriptional regulator
D083_RS07920	COG2186	Transcriptional regulator
D083_RS07925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D083_RS07930	COG2723	6-phospho-beta-galactosidase activity
D083_RS07935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D083_RS07940	COG1447	Phosphotransferase system cellobiose-specific component IIA
D083_RS07945	COG1609	Transcriptional regulator
D083_RS07955	COG0583	DNA-binding transcription factor activity
D083_RS07965	COG3842	ATPase activity
D083_RS07975	COG4149	molybdate abc transporter
D083_RS08000	COG5642	Protein of unknown function (DUF2384)
D083_RS08035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D083_RS08060	COG1522	sequence-specific DNA binding
D083_RS08070	COG1448	Aminotransferase
D083_RS08075	COG0840	transmembrane signaling receptor activity
D083_RS08085	COG0432	Pfam Uncharacterised protein family UPF0047
D083_RS08090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D083_RS08195	COG1609	Transcriptional regulator
D083_RS08200	COG0395	ABC-type sugar transport system, permease component
D083_RS08205	COG1175	transmembrane transport
D083_RS08210	COG3842	ATPase activity
D083_RS08215	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D083_RS08235	COG2971	BadF BadG BcrA BcrD
D083_RS08245	COG0725	ABC transporter, periplasmic molybdate-binding protein
D083_RS08250	COG1121	(ABC) transporter
D083_RS08255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D083_RS08260	COG0803	Belongs to the bacterial solute-binding protein 9 family
D083_RS08275	COG1349	DNA-binding transcription factor activity
D083_RS08280	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D083_RS08285	COG3395	kinase activity
D083_RS08290	COG1454	alcohol dehydrogenase
D083_RS08295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D083_RS08310	COG2731	YhcH YjgK YiaL family protein
D083_RS08320	COG0861	Integral membrane protein TerC family
D083_RS08325	COG3112	Uncharacterised protein family (UPF0231)
D083_RS08340	COG4771	TonB-dependent receptor
D083_RS08345	COG4977	sequence-specific DNA binding
D083_RS08350	COG2079	MmgE PrpD family protein
D083_RS08360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D083_RS08365	COG0508	dehydrogenase complex catalyzes the overall conversion of
D083_RS08370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D083_RS08380	COG1113	amino acid transport
D083_RS08385	COG3725	Membrane protein required for beta-lactamase induction
D083_RS08390	COG3023	N-Acetylmuramoyl-L-alanine amidase
D083_RS08395	COG3248	Nucleoside-binding outer membrane protein
D083_RS08405	COG4969	Belongs to the N-Me-Phe pilin family
D083_RS08410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D083_RS08415	COG1459	type II secretion system
D083_RS08425	COG0237	dephospho-CoA kinase activity
D083_RS08430	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D083_RS08440	COG0494	nUDIX hydrolase
D083_RS08445	COG0653	protein targeting
D083_RS08460	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D083_RS08465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D083_RS08470	COG0849	cell division
D083_RS08475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D083_RS08480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D083_RS08485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D083_RS08490	COG0772	Belongs to the SEDS family
D083_RS08495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D083_RS08500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D083_RS08505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D083_RS08510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D083_RS08515	COG0768	penicillin binding
D083_RS08520	COG3116	cell division
D083_RS08525	COG0275	rRNA processing
D083_RS08530	COG2001	Belongs to the MraZ family
D083_RS08550	COG0028	Belongs to the TPP enzyme family
D083_RS08555	COG1022	Amp-dependent synthetase and ligase
D083_RS08560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D083_RS08565	COG0473	3-isopropylmalate dehydrogenase activity
D083_RS08570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D083_RS08575	COG0066	3-isopropylmalate dehydratase activity
D083_RS08595	COG3033	Beta-eliminating lyase
D083_RS08605	COG4533	DNA binding
D083_RS08615	COG1178	ABC-type Fe3 transport system permease component
D083_RS08620	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D083_RS08630	COG0028	Belongs to the TPP enzyme family
D083_RS08635	COG0440	acetolactate synthase activity
D083_RS08640	COG0586	Pfam SNARE associated Golgi protein
D083_RS08665	COG3157	Type VI secretion system effector, Hcp
D083_RS08675	COG0411	ABC transporter
D083_RS08695	COG0417	DNA replication proofreading
D083_RS08700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D083_RS08705	COG0564	pseudouridine synthase activity
D083_RS08710	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D083_RS08715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D083_RS08720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D083_RS08725	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D083_RS08730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D083_RS08735	COG2967	ApaG domain
D083_RS08740	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D083_RS08745	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D083_RS08750	COG3610	response to peptide
D083_RS08755	COG2966	Psort location CytoplasmicMembrane, score
D083_RS08760	COG1280	lysine exporter protein (LysE YggA)
D083_RS08765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D083_RS08770	COG0505	Belongs to the CarA family
D083_RS08785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D083_RS08790	COG1047	Peptidyl-prolyl cis-trans
D083_RS08795	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D083_RS08800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D083_RS08805	COG0196	riboflavin kinase activity
D083_RS08810	COG0268	Binds directly to 16S ribosomal RNA
D083_RS08815	COG0583	DNA-binding transcription factor activity
D083_RS08820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D083_RS08825	COG0484	heat shock protein binding
D083_RS08835	COG1584	GPR1 FUN34 yaaH family protein
D083_RS08845	COG0521	Mo-molybdopterin cofactor biosynthetic process
D083_RS08850	COG3706	GGDEF domain
D083_RS08855	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D083_RS08860	COG3022	response to hydroperoxide
D083_RS08870	COG0083	homoserine kinase activity
D083_RS08880	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D083_RS08885	COG0745	RESPONSE REGULATOR receiver
D083_RS08890	COG3045	CreA protein
D083_RS08895	COG2207	Transcriptional regulator
D083_RS08895	COG3708	Transcriptional regulator
D083_RS08900	COG0406	alpha-ribazole phosphatase activity
D083_RS08905	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D083_RS08910	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
D083_RS08920	COG0488	(ABC) transporter
D083_RS08925	COG0840	transmembrane signaling receptor activity
D083_RS08935	COG0604	alcohol dehydrogenase
D083_RS08940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D083_RS08945	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D083_RS08950	COG0583	DNA-binding transcription factor activity
D083_RS08955	COG2968	Membrane
D083_RS08960	COG1414	Transcriptional regulator
D083_RS08965	COG0668	transmembrane transport
D083_RS08975	COG0126	phosphoglycerate kinase activity
D083_RS08980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D083_RS08985	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D083_RS08990	COG0738	Major facilitator superfamily
D083_RS08995	COG1166	arginine decarboxylase activity
D083_RS09005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D083_RS09010	COG3091	SprT-like family
D083_RS09015	COG2356	endonuclease I
D083_RS09020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D083_RS09025	COG0189	ligase activity
D083_RS09030	COG1678	Uncharacterized ACR, COG1678
D083_RS09035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D083_RS09040	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D083_RS09045	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D083_RS09050	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D083_RS09055	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D083_RS09060	COG0330	HflC and HflK could
D083_RS09065	COG0330	HflC and HflK could
D083_RS09070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D083_RS09075	COG1923	regulation of RNA biosynthetic process
D083_RS09080	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D083_RS09085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D083_RS09095	COG0802	atpase or kinase
D083_RS09100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D083_RS09100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D083_RS09110	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D083_RS09130	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D083_RS09160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D083_RS09175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D083_RS09180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D083_RS09200	COG0765	amino acid transport
D083_RS09205	COG1126	abc transporter atp-binding protein
D083_RS09215	COG1764	response to oxidative stress
D083_RS09220	COG1846	Transcriptional regulator
D083_RS09225	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D083_RS09235	COG1473	amidohydrolase
D083_RS09245	COG0583	DNA-binding transcription factor activity
D083_RS09250	COG0840	transmembrane signaling receptor activity
D083_RS09265	COG3604	Transcriptional regulator
D083_RS09270	COG2205	protein histidine kinase activity
D083_RS09285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D083_RS09340	COG0840	transmembrane signaling receptor activity
D083_RS09385	COG2977	Belongs to the P-Pant transferase superfamily
D083_RS09400	COG2070	2-Nitropropane dioxygenase
D083_RS09400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D083_RS09410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D083_RS09410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D083_RS09410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D083_RS09410	COG3321	synthase
D083_RS09410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D083_RS09410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D083_RS09410	COG3321	synthase
D083_RS09410	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS09410	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS09410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D083_RS09415	COG4221	oxidoreductase activity
D083_RS09415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D083_RS09415	COG3321	synthase
D083_RS09415	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS09430	COG3321	synthase
D083_RS09430	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS09430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D083_RS09430	COG0300	oxidoreductase activity
D083_RS09430	COG0318	PFAM AMP-dependent synthetase and ligase
D083_RS09435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D083_RS09435	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS09435	COG4221	oxidoreductase activity
D083_RS09435	COG3321	synthase
D083_RS09440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D083_RS09445	COG0300	oxidoreductase activity
D083_RS09445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D083_RS09445	COG4221	oxidoreductase activity
D083_RS09445	COG3321	synthase
D083_RS09450	COG2072	flavoprotein involved in K transport
D083_RS09455	COG3321	synthase
D083_RS09455	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS09455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D083_RS09455	COG4221	oxidoreductase activity
D083_RS09460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D083_RS09465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D083_RS09470	COG3425	synthase
D083_RS09475	COG1024	Enoyl-CoA hydratase
D083_RS09480	COG1024	Enoyl-CoA hydratase
D083_RS09500	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D083_RS09505	COG1162	GTPase activity
D083_RS09510	COG0688	phosphatidylethanolamine metabolic process
D083_RS09515	COG3264	Mechanosensitive ion channel
D083_RS09515	COG1511	domain protein
D083_RS09520	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D083_RS09525	COG1053	succinate dehydrogenase
D083_RS09530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D083_RS09535	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D083_RS09540	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D083_RS09550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D083_RS09555	COG1509	lysine 2,3-aminomutase activity
D083_RS09565	COG4124	Belongs to the glycosyl hydrolase 26 family
D083_RS09570	COG0166	Belongs to the GPI family
D083_RS09575	COG0527	aspartate kinase activity
D083_RS09585	COG1283	sodium-dependent phosphate transmembrane transporter activity
D083_RS09590	COG0471	metal ion transport
D083_RS09595	COG0646	methionine synthase
D083_RS09595	COG1410	methionine synthase
D083_RS09600	COG1414	Transcriptional regulator
D083_RS09605	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
D083_RS09615	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D083_RS09620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D083_RS09650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D083_RS09660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D083_RS09665	COG0009	L-threonylcarbamoyladenylate synthase
D083_RS09670	COG0551	DNA topoisomerase type I activity
D083_RS09675	COG2922	Belongs to the Smg family
D083_RS09680	COG0758	DNA mediated transformation
D083_RS09685	COG0242	peptide deformylase activity
D083_RS09690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D083_RS09695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D083_RS09695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D083_RS09705	COG1970	mechanosensitive ion channel activity
D083_RS09710	COG3036	rescue of stalled ribosome
D083_RS09720	COG0203	ribosomal protein L17
D083_RS09730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D083_RS09740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D083_RS09745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D083_RS09750	COG0201	protein transport
D083_RS09755	COG0200	Binds to the 23S rRNA
D083_RS09760	COG1841	ribosomal large subunit assembly
D083_RS09765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D083_RS09775	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D083_RS09785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D083_RS09790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D083_RS09805	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D083_RS09810	COG0255	Belongs to the universal ribosomal protein uL29 family
D083_RS09815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D083_RS09825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D083_RS09830	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D083_RS09835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D083_RS09840	COG0089	rRNA binding
D083_RS09845	COG0088	Forms part of the polypeptide exit tunnel
D083_RS09850	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D083_RS09855	COG0051	transcription antitermination factor activity, RNA binding
D083_RS09870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D083_RS09875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D083_RS09880	COG0049	tRNA binding
D083_RS09885	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D083_RS09890	COG2168	tRNA wobble position uridine thiolation
D083_RS09895	COG2923	Belongs to the DsrF TusC family
D083_RS09900	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D083_RS09905	COG2964	Protein conserved in bacteria
D083_RS09910	COG2194	sulfuric ester hydrolase activity
D083_RS09915	COG0745	RESPONSE REGULATOR receiver
D083_RS09920	COG0642	Histidine kinase
D083_RS09925	COG1126	abc transporter atp-binding protein
D083_RS09930	COG0765	amino acid transport
D083_RS09940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D083_RS09955	COG0545	Peptidyl-prolyl cis-trans isomerase
D083_RS09960	COG2900	Belongs to the SlyX family
D083_RS09970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D083_RS09985	COG2140	Oxalate decarboxylase
D083_RS09990	COG1047	Peptidyl-prolyl cis-trans
D083_RS09995	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
D083_RS10000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D083_RS10000	COG0475	glutathione-regulated potassium exporter activity
D083_RS10005	COG2249	NAD(P)H dehydrogenase (quinone) activity
D083_RS10010	COG0488	(ABC) transporter
D083_RS10020	COG0429	hydrolase of the alpha beta-hydrolase fold
D083_RS10030	COG3954	Phosphoribulokinase
D083_RS10035	COG1765	OsmC-like protein
D083_RS10055	COG4753	response regulator
D083_RS10055	COG2207	Transcriptional regulator
D083_RS10065	COG1404	Belongs to the peptidase S8 family
D083_RS10070	COG3179	chitinase
D083_RS10110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D083_RS10115	COG4948	Mandelate Racemase Muconate Lactonizing
D083_RS10125	COG0546	phosphoglycolate phosphatase activity
D083_RS10130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D083_RS10145	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D083_RS10150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D083_RS10160	COG4796	Type ii and iii secretion system protein
D083_RS10185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D083_RS10190	COG0494	nUDIX hydrolase
D083_RS10200	COG1011	Hydrolase
D083_RS10205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D083_RS10210	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D083_RS10215	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D083_RS10230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D083_RS10240	COG2183	response to ionizing radiation
D083_RS10250	COG2267	carboxylic ester hydrolase activity
D083_RS10260	COG0316	Belongs to the HesB IscA family
D083_RS10260	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D083_RS10265	COG1640	4-alpha-glucanotransferase
D083_RS10270	COG0058	SHG alpha-glucan phosphorylase activity
D083_RS10275	COG1349	DNA-binding transcription factor activity
D083_RS10280	COG0705	Rhomboid family
D083_RS10285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D083_RS10295	COG2731	YhcH YjgK YiaL family protein
D083_RS10300	COG2271	Major facilitator Superfamily
D083_RS10310	COG5001	Diguanylate cyclase
D083_RS10320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D083_RS10325	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D083_RS10330	COG0058	SHG alpha-glucan phosphorylase activity
D083_RS10335	COG0297	glycogen (starch) synthase activity
D083_RS10340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D083_RS10355	COG3275	phosphorelay sensor kinase activity
D083_RS10365	COG1278	Cold shock
D083_RS10375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D083_RS10380	COG2095	MarC family integral membrane protein
D083_RS10385	COG2610	gluconate transmembrane transporter activity
D083_RS10390	COG3265	gluconokinase activity
D083_RS10395	COG1609	Transcriptional regulator
D083_RS10405	COG1741	Belongs to the pirin family
D083_RS10410	COG0247	lactate metabolic process
D083_RS10415	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
D083_RS10420	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D083_RS10425	COG2271	Major facilitator Superfamily
D083_RS10430	COG0584	glycerophosphoryl diester phosphodiesterase
D083_RS10435	COG0561	phosphatase activity
D083_RS10440	COG2267	carboxylic ester hydrolase activity
D083_RS10445	COG1280	lysine exporter protein (LysE YggA)
D083_RS10450	COG1280	lysine exporter protein (LysE YggA)
D083_RS10455	COG0514	ATP-dependent DNA helicase (RecQ)
D083_RS10465	COG2050	protein possibly involved in aromatic compounds catabolism
D083_RS10475	COG3180	Ammonia monooxygenase
D083_RS10480	COG0598	Magnesium transport protein CorA
D083_RS10485	COG0210	DNA helicase
D083_RS10490	COG1011	Hydrolase
D083_RS10505	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D083_RS10525	COG0181	hydroxymethylbilane synthase activity
D083_RS10530	COG1587	Uroporphyrinogen-III synthase
D083_RS10535	COG2959	enzyme of heme biosynthesis
D083_RS10540	COG3071	HemY protein
D083_RS10545	COG1473	amidohydrolase
D083_RS10550	COG1126	abc transporter atp-binding protein
D083_RS10555	COG0765	amino acid transport
D083_RS10560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D083_RS10565	COG0456	acetyltransferase
D083_RS10570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D083_RS10580	COG0371	Dehydrogenase
D083_RS10585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D083_RS10615	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D083_RS10625	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D083_RS10630	COG2244	polysaccharide biosynthetic process
D083_RS10635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D083_RS10645	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D083_RS10650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D083_RS10655	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D083_RS10660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D083_RS10665	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D083_RS10670	COG3118	belongs to the thioredoxin family
D083_RS10675	COG0513	Belongs to the DEAD box helicase family
D083_RS10680	COG0248	Ppx GppA phosphatase
D083_RS10710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D083_RS10715	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D083_RS10715	COG0506	proline dehydrogenase activity
D083_RS10715	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D083_RS10720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D083_RS10730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D083_RS10750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D083_RS10760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D083_RS10765	COG3978	acetolactate synthase activity
D083_RS10780	COG2814	Major facilitator Superfamily
D083_RS10790	COG3085	chromosome segregation
D083_RS10795	COG0583	DNA-binding transcription factor activity
D083_RS10835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D083_RS10845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D083_RS10855	COG1309	transcriptional regulator
D083_RS10860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D083_RS10870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D083_RS10870	COG0678	peroxiredoxin activity
D083_RS10880	COG0527	aspartate kinase activity
D083_RS10880	COG0460	homoserine dehydrogenase
D083_RS10885	COG0626	cystathionine gamma-synthase activity
D083_RS10890	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
D083_RS10900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D083_RS10905	COG1609	Transcriptional regulator
D083_RS10910	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D083_RS10915	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D083_RS10920	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D083_RS10925	COG1575	Belongs to the MenA family. Type 1 subfamily
D083_RS10930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D083_RS10935	COG3074	FtsZ-dependent cytokinesis
D083_RS10940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D083_RS10950	COG1494	fructose-1,6-bisphosphatase
D083_RS10960	COG3152	Membrane
D083_RS10970	COG0149	triose-phosphate isomerase activity
D083_RS10980	COG2957	Belongs to the agmatine deiminase family
D083_RS10985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D083_RS10990	COG0205	6-phosphofructokinase activity
D083_RS10995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D083_RS11010	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D083_RS11035	COG3678	ATP-independent chaperone mediated protein folding
D083_RS11040	COG0745	RESPONSE REGULATOR receiver
D083_RS11045	COG2205	protein histidine kinase activity
D083_RS11060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D083_RS11065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D083_RS11075	COG0679	Auxin Efflux Carrier
D083_RS11080	COG0584	glycerophosphoryl diester phosphodiesterase
D083_RS11085	COG3842	ATPase activity
D083_RS11090	COG0395	ABC-type sugar transport system, permease component
D083_RS11095	COG1175	transmembrane transport
D083_RS11100	COG1653	transport
D083_RS11110	COG0840	transmembrane signaling receptor activity
D083_RS11115	COG0840	transmembrane signaling receptor activity
D083_RS11120	COG0840	transmembrane signaling receptor activity
D083_RS11130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D083_RS11140	COG0411	ABC transporter
D083_RS11145	COG4177	L-phenylalanine transmembrane transporter activity
D083_RS11150	COG0559	Belongs to the binding-protein-dependent transport system permease family
D083_RS11155	COG0683	leucine binding
D083_RS11160	COG0456	acetyltransferase
D083_RS11170	COG2177	Part of the ABC transporter FtsEX involved in
D083_RS11175	COG2884	Cell division ATP-binding protein ftsE
D083_RS11180	COG0552	protein localization to endoplasmic reticulum
D083_RS11180	COG0552	protein localization to endoplasmic reticulum
D083_RS11185	COG3493	citrate carrier protein
D083_RS11190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D083_RS11200	COG0742	ribosomal rna small subunit methyltransferase
D083_RS11205	COG3776	membrane
D083_RS11215	COG3714	YhhN family
D083_RS11220	COG0425	Belongs to the sulfur carrier protein TusA family
D083_RS11225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D083_RS11235	COG0477	Major facilitator Superfamily
D083_RS11240	COG1295	ribonuclease BN
D083_RS11245	COG1942	4-Oxalocrotonate Tautomerase
D083_RS11250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D083_RS11260	COG1301	dicarboxylic acid transport
D083_RS11265	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D083_RS11275	COG0457	Tetratricopeptide repeat
D083_RS11285	COG1215	transferase activity, transferring glycosyl groups
D083_RS11290	COG0489	protein tyrosine kinase activity
D083_RS11305	COG2378	regulation of single-species biofilm formation
D083_RS11315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D083_RS11335	COG4608	Belongs to the ABC transporter superfamily
D083_RS11340	COG0444	Belongs to the ABC transporter superfamily
D083_RS11345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS11350	COG0601	transmembrane transport
D083_RS11355	COG0747	negative chemotaxis
D083_RS11360	COG3493	citrate carrier protein
D083_RS11365	COG4565	transcriptional regulatory protein
D083_RS11370	COG3290	protein histidine kinase activity
D083_RS11375	COG0471	metal ion transport
D083_RS11380	COG0071	Belongs to the small heat shock protein (HSP20) family
D083_RS11385	COG0071	Belongs to the small heat shock protein (HSP20) family
D083_RS11390	COG5645	(Lipo)protein
D083_RS11400	COG0477	Major facilitator Superfamily
D083_RS11410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D083_RS11425	COG2085	NADP oxidoreductase coenzyme F420-dependent
D083_RS11430	COG1733	regulation of RNA biosynthetic process
D083_RS11435	COG0823	Involved in the tonB-independent uptake of proteins
D083_RS11455	COG0561	phosphatase activity
D083_RS11465	COG0589	response to stress
D083_RS11475	COG0306	phosphate transporter
D083_RS11480	COG2081	HI0933 family
D083_RS11510	COG0395	ABC-type sugar transport system, permease component
D083_RS11560	COG1653	transport
D083_RS11570	COG1175	transmembrane transport
D083_RS11580	COG2814	Major facilitator Superfamily
D083_RS11585	COG0583	DNA-binding transcription factor activity
D083_RS11600	COG4221	oxidoreductase activity
D083_RS11615	COG2194	sulfuric ester hydrolase activity
D083_RS11620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D083_RS11625	COG0194	GDP metabolic process
D083_RS11635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D083_RS11640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D083_RS11645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D083_RS11650	COG2233	PERMEase
D083_RS11655	COG2982	Protein involved in outer membrane biogenesis
D083_RS11660	COG0456	acetyltransferase
D083_RS11665	COG1490	D-aminoacyl-tRNA deacylase activity
D083_RS11670	COG1011	Hydrolase
D083_RS11675	COG1217	gtp-binding protein TYPA
D083_RS11685	COG3852	Histidine kinase
D083_RS11700	COG3078	GTPase activator activity
D083_RS11705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D083_RS11715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D083_RS11720	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D083_RS11725	COG3084	Protein conserved in bacteria
D083_RS11735	COG1763	Mo-molybdopterin cofactor biosynthetic process
D083_RS11770	COG1609	Transcriptional regulator
D083_RS11775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D083_RS11780	COG1879	ABC-type sugar transport system periplasmic component
D083_RS11785	COG1172	Belongs to the binding-protein-dependent transport system permease family
D083_RS11790	COG1129	ABC transporter
D083_RS11795	COG1869	D-ribose catabolic process
D083_RS11800	COG3158	transport of potassium into the cell
D083_RS11805	COG0714	Associated with various cellular activities
D083_RS11810	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D083_RS11815	COG1522	sequence-specific DNA binding
D083_RS11820	COG0716	FMN binding
D083_RS11825	COG0445	tRNA wobble uridine modification
D083_RS11830	COG0357	Ribosomal RNA small subunit methyltransferase G
D083_RS11835	COG3312	ion transport
D083_RS11840	COG0356	it plays a direct role in the translocation of protons across the membrane
D083_RS11850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D083_RS11855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D083_RS11860	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D083_RS11865	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D083_RS11870	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D083_RS11875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D083_RS11885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D083_RS11890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D083_RS11915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D083_RS11920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D083_RS11975	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS11985	COG3706	GGDEF domain
D083_RS11990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D083_RS11995	COG0573	inorganic phosphate transmembrane transporter activity
D083_RS12000	COG0581	inorganic phosphate transmembrane transporter activity
D083_RS12005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D083_RS12015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D083_RS12025	COG0765	amino acid transport
D083_RS12030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D083_RS12035	COG2252	PERMEase
D083_RS12040	COG2091	lysine biosynthetic process via aminoadipic acid
D083_RS12045	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D083_RS12050	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D083_RS12050	COG0493	'glutamate synthase
D083_RS12055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D083_RS12060	COG0463	Glycosyl transferase, family 2
D083_RS12070	COG0726	polysaccharide deacetylase
D083_RS12075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D083_RS12080	COG2076	Multidrug Resistance protein
D083_RS12085	COG2076	Multidrug Resistance protein
D083_RS12095	COG2910	NAD(P)H-binding
D083_RS12100	COG1733	regulation of RNA biosynthetic process
D083_RS12110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D083_RS12120	COG1396	sequence-specific DNA binding
D083_RS12125	COG3550	peptidyl-serine autophosphorylation
D083_RS12130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D083_RS12135	COG0706	membrane insertase activity
D083_RS12140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D083_RS12145	COG0594	ribonuclease P activity
D083_RS12150	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D083_RS12160	COG0592	DNA-directed DNA polymerase activity
D083_RS12165	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D083_RS12180	COG0742	ribosomal rna small subunit methyltransferase
D083_RS12185	COG0339	signal peptide processing
D083_RS12195	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D083_RS12200	COG1234	tRNA 3'-trailer cleavage
D083_RS12205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D083_RS12210	COG0471	metal ion transport
D083_RS12215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D083_RS12220	COG2188	Transcriptional regulator
D083_RS12225	COG1696	Membrane protein involved in D-alanine export
D083_RS12245	COG1522	sequence-specific DNA binding
D083_RS12250	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D083_RS12255	COG1509	lysine 2,3-aminomutase activity
D083_RS12275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D083_RS12280	COG4191	Histidine kinase
D083_RS12300	COG0583	DNA-binding transcription factor activity
D083_RS12320	COG0837	glucose binding
D083_RS12330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D083_RS12340	COG4172	Belongs to the ABC transporter superfamily
D083_RS12345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS12350	COG0601	transmembrane transport
D083_RS12355	COG0747	negative chemotaxis
D083_RS12365	COG3977	Valine--pyruvate aminotransferase
D083_RS12375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D083_RS12380	COG0456	acetyltransferase
D083_RS12385	COG2818	Glycosylase
D083_RS12400	COG0751	glycine-tRNA ligase activity
D083_RS12405	COG3842	ATPase activity
D083_RS12410	COG1940	carbohydrate kinase activity
D083_RS12415	COG1940	carbohydrate kinase activity
D083_RS12430	COG1175	transmembrane transport
D083_RS12435	COG0395	ABC-type sugar transport system, permease component
D083_RS12455	COG3842	ATPase activity
D083_RS12475	COG2213	PTS system mannitol-specific
D083_RS12475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D083_RS12480	COG0246	Mannitol dehydrogenase
D083_RS12485	COG3722	fumarate hydratase activity
D083_RS12490	COG0840	transmembrane signaling receptor activity
D083_RS12495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D083_RS12500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D083_RS12505	COG1012	belongs to the aldehyde dehydrogenase family
D083_RS12510	COG1070	Carbohydrate kinase
D083_RS12515	COG2115	Belongs to the xylose isomerase family
D083_RS12520	COG4213	ABC transporter substrate-binding protein
D083_RS12525	COG1129	ABC transporter
D083_RS12530	COG4214	carbohydrate transport
D083_RS12535	COG1609	Transcriptional regulator
D083_RS12535	COG2207	Transcriptional regulator
D083_RS12560	COG0137	argininosuccinate synthase activity
D083_RS12565	COG1846	Transcriptional regulator
D083_RS12570	COG0697	spore germination
D083_RS12575	COG2313	pseudouridylate synthase activity
D083_RS12580	COG0546	phosphoglycolate phosphatase activity
D083_RS12585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D083_RS12615	COG2207	Transcriptional regulator
D083_RS12615	COG1917	Cupin 2, conserved barrel domain protein
D083_RS12620	COG0577	efflux transmembrane transporter activity
D083_RS12620	COG1136	(ABC) transporter
D083_RS12625	COG0577	efflux transmembrane transporter activity
D083_RS12625	COG1136	(ABC) transporter
D083_RS12665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D083_RS12685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D083_RS12700	COG0318	PFAM AMP-dependent synthetase and ligase
D083_RS12720	COG2771	luxR family
D083_RS12725	COG3916	Acyl-homoserine-lactone synthase
D083_RS12785	COG3423	Transcriptional regulator
D083_RS12795	COG1561	YicC-like family, N-terminal region
D083_RS12800	COG0583	DNA-binding transcription factor activity
D083_RS12810	COG0747	negative chemotaxis
D083_RS12815	COG0601	transmembrane transport
D083_RS12820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS12825	COG0444	Belongs to the ABC transporter superfamily
D083_RS12830	COG4608	Belongs to the ABC transporter superfamily
D083_RS12860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS12865	COG0601	transmembrane transport
D083_RS12870	COG0747	negative chemotaxis
D083_RS12875	COG4172	Belongs to the ABC transporter superfamily
D083_RS12880	COG4948	Mandelate Racemase Muconate Lactonizing
D083_RS12895	COG2149	membrane
D083_RS12900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D083_RS12905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D083_RS12910	COG1309	transcriptional regulator
D083_RS12915	COG0756	dUTP diphosphatase activity
D083_RS12920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D083_RS12925	COG2003	Belongs to the UPF0758 family
D083_RS12945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D083_RS12950	COG1216	Glycosyl transferase, family 2
D083_RS12955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D083_RS12965	COG1519	Transferase
D083_RS12970	COG0438	transferase activity, transferring glycosyl groups
D083_RS12990	COG0859	PFAM glycosyl transferase family 9
D083_RS13000	COG0859	PFAM glycosyl transferase family 9
D083_RS13005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D083_RS13010	COG0156	8-amino-7-oxononanoate synthase activity
D083_RS13015	COG1063	alcohol dehydrogenase
D083_RS13020	COG2861	carbohydrate metabolic process
D083_RS13025	COG4942	peptidase
D083_RS13030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D083_RS13035	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D083_RS13040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D083_RS13045	COG1045	serine acetyltransferase
D083_RS13060	COG0583	DNA-binding transcription factor activity
D083_RS13065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D083_RS13070	COG0412	Dienelactone hydrolase
D083_RS13075	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D083_RS13095	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D083_RS13100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D083_RS13105	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D083_RS13110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D083_RS13115	COG0165	Argininosuccinate lyase
D083_RS13120	COG1322	Protein conserved in bacteria
D083_RS13125	COG2226	methyltransferase
D083_RS13130	COG3165	ubiquinone biosynthetic process from chorismate
D083_RS13135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D083_RS13150	COG0805	protein transport
D083_RS13155	COG0084	hydrolase, TatD family'
D083_RS13170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D083_RS13200	COG0183	Belongs to the thiolase family
D083_RS13205	COG1024	Enoyl-CoA hydratase
D083_RS13205	COG1250	3-hydroxyacyl-CoA dehydrogenase
D083_RS13210	COG0006	proline dipeptidase activity
D083_RS13215	COG1739	Uncharacterized protein family UPF0029
D083_RS13220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D083_RS13265	COG1072	(Pantothenic acid kinase))
D083_RS13300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D083_RS13310	COG0250	Participates in transcription elongation, termination and antitermination
D083_RS13315	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D083_RS13330	COG0222	ribosome binding
D083_RS13345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D083_RS13365	COG5457	Domain of unknown function (DUF1127)
D083_RS13370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D083_RS13375	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D083_RS13380	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
D083_RS13400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D083_RS13405	COG2022	thiamine diphosphate biosynthetic process
D083_RS13410	COG2104	thiamine diphosphate biosynthetic process
D083_RS13415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D083_RS13420	COG0352	thiamine-phosphate diphosphorylase activity
D083_RS13425	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D083_RS13430	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D083_RS13435	COG2816	NAD+ diphosphatase activity
D083_RS13440	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D083_RS13445	COG1515	deoxyribonuclease V activity
D083_RS13465	COG0151	Belongs to the GarS family
D083_RS13470	COG0138	bifunctional purine biosynthesis protein purh
D083_RS13505	COG1126	abc transporter atp-binding protein
D083_RS13510	COG0765	amino acid transport
D083_RS13515	COG4597	amino acid ABC transporter
D083_RS13520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D083_RS13525	COG0504	CTP synthase activity
D083_RS13530	COG0765	amino acid transport
D083_RS13535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D083_RS13545	COG4221	oxidoreductase activity
D083_RS13560	COG4221	oxidoreductase activity
D083_RS13565	COG1064	alcohol dehydrogenase
D083_RS13570	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D083_RS13580	COG2264	protein methyltransferase activity
D083_RS13585	COG4145	pantothenate transmembrane transporter activity
D083_RS13590	COG3924	membrane
D083_RS13595	COG0439	Biotin carboxylase
D083_RS13600	COG0511	ligase activity, forming carbon-carbon bonds
D083_RS13605	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D083_RS13610	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D083_RS13615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D083_RS13620	COG0604	alcohol dehydrogenase
D083_RS13625	COG2200	EAL domain
D083_RS13625	COG2199	diguanylate cyclase activity
D083_RS13630	COG1077	Cell shape determining protein MreB Mrl
D083_RS13635	COG1792	Involved in formation and maintenance of cell shape
D083_RS13640	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D083_RS13645	COG0424	maF-like protein
D083_RS13655	COG3164	Protein of unknown function
D083_RS13660	COG0312	modulator of DNA gyrase
D083_RS13665	COG0583	DNA-binding transcription factor activity
D083_RS13675	COG1566	PFAM secretion protein HlyD family protein
D083_RS13680	COG1289	transmembrane transporter activity
D083_RS13690	COG1280	lysine exporter protein (LysE YggA)
D083_RS13700	COG3028	Belongs to the UPF0307 family
D083_RS13705	COG0312	modulator of DNA gyrase
D083_RS13710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D083_RS13715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D083_RS13720	COG1660	Displays ATPase and GTPase activities
D083_RS13735	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D083_RS13740	COG1137	ATPase activity
D083_RS13745	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D083_RS13750	COG3117	lipopolysaccharide transmembrane transporter activity
D083_RS13755	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D083_RS13760	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D083_RS13760	COG0517	IMP dehydrogenase activity
D083_RS13765	COG0530	calcium, potassium:sodium antiporter activity
D083_RS13770	COG1127	ABC transporter
D083_RS13775	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D083_RS13780	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D083_RS13785	COG2854	intermembrane phospholipid transfer
D083_RS13790	COG3113	response to antibiotic
D083_RS13795	COG5007	Belongs to the BolA IbaG family
D083_RS13800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D083_RS13805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D083_RS13810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D083_RS13815	COG3105	Protein conserved in bacteria
D083_RS13820	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D083_RS13840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D083_RS13845	COG0625	glutathione transferase activity
D083_RS13850	COG2969	positive regulation of protein catabolic process
D083_RS13860	COG0493	'glutamate synthase
D083_RS13865	COG0069	glutamate synthase activity
D083_RS13865	COG0067	glutamate synthase
D083_RS13865	COG0070	glutamate synthase
D083_RS13870	COG1242	4 iron, 4 sulfur cluster binding
D083_RS13875	COG5002	protein histidine kinase activity
D083_RS13875	COG0784	Response regulator, receiver
D083_RS13875	COG2198	Histidine kinase
D083_RS13880	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D083_RS13885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D083_RS13895	COG2823	Periplasmic or secreted lipoprotein
D083_RS13900	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D083_RS13905	COG0792	nuclease activity
D083_RS13910	COG3107	peptidoglycan biosynthetic process
D083_RS13915	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D083_RS13925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D083_RS13930	COG3384	dioxygenase
D083_RS13935	COG0754	glutathionylspermidine amidase activity
D083_RS13940	COG5463	Belongs to the UPF0441 family
D083_RS13945	COG1538	Outer membrane efflux protein
D083_RS13950	COG0494	nUDIX hydrolase
D083_RS13955	COG3151	Protein conserved in bacteria
D083_RS13960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D083_RS13965	COG3150	esterase
D083_RS13975	COG0583	DNA-binding transcription factor activity
D083_RS13980	COG2249	NAD(P)H dehydrogenase (quinone) activity
D083_RS13985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D083_RS13990	COG0204	Acyl-transferase
D083_RS13995	COG2132	Multicopper oxidase
D083_RS14000	COG0656	L-ascorbic acid biosynthetic process
D083_RS14005	COG1979	alcohol dehydrogenase
D083_RS14010	COG2207	Transcriptional regulator
D083_RS14015	COG0586	Pfam SNARE associated Golgi protein
D083_RS14020	COG0626	cystathionine gamma-synthase activity
D083_RS14025	COG0811	peptide transport
D083_RS14030	COG0848	biopolymer transport protein
D083_RS14080	COG1328	CTP reductase activity
D083_RS14090	COG4166	transmembrane transport
D083_RS14095	COG0601	transmembrane transport
D083_RS14100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS14110	COG3157	Type VI secretion system effector, Hcp
D083_RS14140	COG2308	Evidence 4 Homologs of previously reported genes of
D083_RS14150	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
D083_RS14155	COG0540	Belongs to the ATCase OTCase family
D083_RS14160	COG2731	YhcH YjgK YiaL family protein
D083_RS14170	COG1263	PTS System
D083_RS14170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D083_RS14170	COG2190	(PTS) system
D083_RS14175	COG2723	6-phospho-beta-galactosidase activity
D083_RS14180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D083_RS14195	COG1396	sequence-specific DNA binding
D083_RS14200	COG0454	-acetyltransferase
D083_RS14205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D083_RS14210	COG0840	transmembrane signaling receptor activity
D083_RS14215	COG0525	valine-tRNA ligase activity
D083_RS14220	COG2927	DNA polymerase III (CHI subunit)
D083_RS14225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D083_RS14230	COG0795	lipopolysaccharide-transporting ATPase activity
D083_RS14235	COG0795	lipopolysaccharide-transporting ATPase activity
D083_RS14245	COG0582	viral genome integration into host DNA
D083_RS14270	COG3423	Transcriptional regulator
D083_RS14325	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D083_RS14350	COG4106	trans-aconitate 2-methyltransferase activity
D083_RS14375	COG1522	sequence-specific DNA binding
D083_RS14395	COG1280	lysine exporter protein (LysE YggA)
D083_RS14410	COG2814	Major facilitator Superfamily
D083_RS14425	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D083_RS14430	COG1349	DNA-binding transcription factor activity
D083_RS14435	COG3959	Transketolase, thiamine diphosphate binding domain
D083_RS14440	COG3958	Transketolase
D083_RS14445	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS14450	COG1879	ABC-type sugar transport system periplasmic component
D083_RS14460	COG1129	ABC transporter
D083_RS14465	COG1172	Belongs to the binding-protein-dependent transport system permease family
D083_RS14470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D083_RS14500	COG0747	negative chemotaxis
D083_RS14510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS14515	COG0444	Belongs to the ABC transporter superfamily
D083_RS14520	COG4608	Belongs to the ABC transporter superfamily
D083_RS14535	COG0583	DNA-binding transcription factor activity
D083_RS14550	COG1605	Chorismate mutase
D083_RS14560	COG1418	mRNA catabolic process
D083_RS14565	COG1414	Transcriptional regulator
D083_RS14570	COG0840	transmembrane signaling receptor activity
D083_RS14585	COG0235	Class ii aldolase
D083_RS14590	COG4806	L-rhamnose isomerase
D083_RS14595	COG1070	Carbohydrate kinase
D083_RS14600	COG1917	Cupin 2, conserved barrel domain protein
D083_RS14600	COG2169	Transcriptional regulator
D083_RS14605	COG1917	Cupin 2, conserved barrel domain protein
D083_RS14605	COG4977	sequence-specific DNA binding
D083_RS14620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS14630	COG0747	negative chemotaxis
D083_RS14635	COG3477	response to acidic pH
D083_RS14645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D083_RS14650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D083_RS14655	COG0006	proline dipeptidase activity
D083_RS14660	COG3079	Belongs to the UPF0149 family
D083_RS14665	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D083_RS14675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D083_RS14690	COG0560	Phosphoserine phosphatase
D083_RS14695	COG3726	membrane protein affecting hemolysin expression
D083_RS14715	COG2823	Periplasmic or secreted lipoprotein
D083_RS14730	COG0084	hydrolase, TatD family'
D083_RS14740	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D083_RS14745	COG0840	transmembrane signaling receptor activity
D083_RS14765	COG1473	amidohydrolase
D083_RS14780	COG1120	ATPase activity
D083_RS14790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D083_RS14800	COG3634	alkyl hydroperoxide reductase activity
D083_RS14815	COG2351	hydroxyisourate hydrolase activity
D083_RS14855	COG1609	Transcriptional regulator
D083_RS14900	COG0297	glycogen (starch) synthase activity
D083_RS14905	COG0438	transferase activity, transferring glycosyl groups
D083_RS14905	COG0297	glycogen (starch) synthase activity
D083_RS14920	COG1045	serine acetyltransferase
D083_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS14955	COG0300	oxidoreductase activity
D083_RS15020	COG0582	viral genome integration into host DNA
D083_RS15030	COG1309	transcriptional regulator
D083_RS15035	COG4232	protein-disulfide reductase activity
D083_RS15040	COG1324	tolerance protein
D083_RS15045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D083_RS15060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D083_RS15065	COG0459	protein refolding
D083_RS15070	COG3161	chorismate lyase activity
D083_RS15075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D083_RS15080	COG2937	Belongs to the GPAT DAPAT family
D083_RS15085	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D083_RS15090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D083_RS15095	COG0735	belongs to the Fur family
D083_RS15100	COG1741	Belongs to the pirin family
D083_RS15105	COG0583	DNA-binding transcription factor activity
D083_RS15110	COG0435	Glutathione S-transferase
D083_RS15115	COG2259	Doxx family
D083_RS15125	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
D083_RS15130	COG4575	ribosome binding
D083_RS15140	COG0586	Pfam SNARE associated Golgi protein
D083_RS15150	COG2271	Major facilitator Superfamily
D083_RS15155	COG1904	glucuronate isomerase
D083_RS15160	COG0246	Mannitol dehydrogenase
D083_RS15165	COG2721	sulfolactate sulfo-lyase activity
D083_RS15175	COG0861	Integral membrane protein TerC family
D083_RS15180	COG2813	Specifically methylates the guanine in position
D083_RS15195	COG2197	response regulator
D083_RS15205	COG2271	Major facilitator Superfamily
D083_RS15210	COG2271	Major facilitator Superfamily
D083_RS15215	COG3678	ATP-independent chaperone mediated protein folding
D083_RS15250	COG1309	transcriptional regulator
D083_RS15255	COG0667	Aldo Keto reductase
D083_RS15270	COG0604	alcohol dehydrogenase
D083_RS15305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D083_RS15310	COG0358	DNA primase activity
D083_RS15315	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D083_RS15320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D083_RS15325	COG1438	arginine binding
D083_RS15335	COG3423	Transcriptional regulator
D083_RS15350	COG0142	geranyltranstransferase activity
D083_RS15355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D083_RS15365	COG0697	spore germination
D083_RS15370	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D083_RS15375	COG2027	D-alanyl-D-alanine carboxypeptidase
D083_RS15385	COG1534	Rna-binding protein
D083_RS15390	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D083_RS15395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D083_RS15400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D083_RS15405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D083_RS15410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D083_RS15425	COG0779	Required for maturation of 30S ribosomal subunits
D083_RS15430	COG0195	Participates in both transcription termination and antitermination
D083_RS15435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D083_RS15440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D083_RS15445	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D083_RS15450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D083_RS15455	COG1185	polyribonucleotide nucleotidyltransferase activity
D083_RS15465	COG0513	Belongs to the DEAD box helicase family
D083_RS15470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D083_RS15475	COG0826	peptidase U32
D083_RS15480	COG0826	peptidase U32
D083_RS15485	COG3154	lipid carrier protein
D083_RS15490	COG3153	acetyltransferase
D083_RS15495	COG2827	Endonuclease containing a URI domain
D083_RS15500	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D083_RS15505	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D083_RS15510	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D083_RS15515	COG0813	purine-nucleoside phosphorylase activity
D083_RS15550	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
D083_RS15555	COG2813	Specifically methylates the guanine in position
D083_RS15560	COG0667	Aldo Keto reductase
D083_RS15565	COG0583	DNA-binding transcription factor activity
D083_RS15620	COG1454	alcohol dehydrogenase
D083_RS15625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D083_RS15630	COG0509	glycine decarboxylation via glycine cleavage system
D083_RS15635	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D083_RS15635	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D083_RS15640	COG1280	lysine exporter protein (LysE YggA)
D083_RS15650	COG1272	protein, Hemolysin III
D083_RS15655	COG0354	folic acid binding
D083_RS15660	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D083_RS15670	COG0716	FMN binding
D083_RS15675	COG0477	Major facilitator Superfamily
D083_RS15680	COG4974	Belongs to the 'phage' integrase family
D083_RS15685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D083_RS15690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D083_RS15725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D083_RS15735	COG0642	Histidine kinase
D083_RS15750	COG0671	phosphoesterase, PA-phosphatase related
D083_RS15755	COG1733	regulation of RNA biosynthetic process
D083_RS15770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D083_RS15775	COG1653	transport
D083_RS15780	COG3842	ATPase activity
D083_RS15785	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D083_RS15790	COG0395	ABC-type sugar transport system, permease component
D083_RS15795	COG1175	transmembrane transport
D083_RS15805	COG1560	Kdo2-lipid A biosynthetic process
D083_RS15810	COG2252	PERMEase
D083_RS15815	COG0025	NhaP-type Na H and K H
D083_RS15820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D083_RS15825	COG3162	membrane
D083_RS15830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D083_RS15850	COG4948	Mandelate Racemase Muconate Lactonizing
D083_RS15855	COG0747	negative chemotaxis
D083_RS15860	COG0601	transmembrane transport
D083_RS15865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS15870	COG0444	Belongs to the ABC transporter superfamily
D083_RS15875	COG4608	Belongs to the ABC transporter superfamily
D083_RS15885	COG3712	iron ion homeostasis
D083_RS15905	COG0246	Mannitol dehydrogenase
D083_RS15910	COG2814	Major facilitator Superfamily
D083_RS15920	COG1846	Transcriptional regulator
D083_RS15925	COG1376	ErfK ybiS ycfS ynhG family protein
D083_RS15930	COG1013	pyruvate-flavodoxin oxidoreductase activity
D083_RS15930	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D083_RS15930	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D083_RS15930	COG0674	pyruvate-flavodoxin oxidoreductase activity
D083_RS15945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D083_RS15950	COG0765	amino acid transport
D083_RS15955	COG0765	amino acid transport
D083_RS15995	COG2211	Major facilitator Superfamily
D083_RS16015	COG1181	Belongs to the D-alanine--D-alanine ligase family
D083_RS16040	COG2814	Major facilitator Superfamily
D083_RS16045	COG0583	DNA-binding transcription factor activity
D083_RS16065	COG3962	Belongs to the TPP enzyme family
D083_RS16070	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D083_RS16095	COG4133	protoheme IX ABC transporter activity
D083_RS16100	COG0673	inositol 2-dehydrogenase activity
D083_RS16115	COG1172	Belongs to the binding-protein-dependent transport system permease family
D083_RS16120	COG0673	inositol 2-dehydrogenase activity
D083_RS16125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D083_RS16135	COG3718	enzyme involved in inositol metabolism
D083_RS16145	COG2951	lytic endotransglycosylase activity
D083_RS16150	COG0583	DNA-binding transcription factor activity
D083_RS16155	COG2271	Major facilitator Superfamily
D083_RS16160	COG4948	Mandelate Racemase Muconate Lactonizing
D083_RS16250	COG2916	Histone family protein nucleoid-structuring protein H-NS
D083_RS16270	COG3423	Transcriptional regulator
D083_RS16290	COG4104	PAAR repeat-containing protein
D083_RS16290	COG3209	COG3209 Rhs family protein
D083_RS16300	COG3501	Rhs element vgr protein
D083_RS16320	COG2867	negative regulation of translational initiation
D083_RS16325	COG2914	Belongs to the UPF0125 (RnfH) family
D083_RS16335	COG0497	DNA recombination
D083_RS16340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D083_RS16350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D083_RS16355	COG1914	H( )-stimulated, divalent metal cation uptake system
D083_RS16360	COG0494	nUDIX hydrolase
D083_RS16365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D083_RS16375	COG1671	Belongs to the UPF0178 family
D083_RS16380	COG0408	coproporphyrinogen oxidase activity
D083_RS16385	COG0456	acetyltransferase
D083_RS16390	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D083_RS16395	COG4771	TonB-dependent receptor
D083_RS16400	COG0612	Peptidase, M16
D083_RS16405	COG4178	(ABC) transporter
D083_RS16420	COG3423	Transcriptional regulator
D083_RS16435	COG2837	iron assimilation
D083_RS16450	COG3157	Type VI secretion system effector, Hcp
D083_RS16465	COG1136	(ABC) transporter
D083_RS16465	COG0577	efflux transmembrane transporter activity
D083_RS16470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D083_RS16475	COG0745	RESPONSE REGULATOR receiver
D083_RS16480	COG2205	protein histidine kinase activity
D083_RS16485	COG1024	Enoyl-CoA hydratase
D083_RS16490	COG1733	regulation of RNA biosynthetic process
D083_RS16495	COG2190	(PTS) system
D083_RS16505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D083_RS16520	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D083_RS16525	COG3115	cell septum assembly
D083_RS16530	COG0531	amino acid
D083_RS16540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D083_RS16550	COG0446	pyridine nucleotide-disulphide oxidoreductase
D083_RS16555	COG0426	domain, Protein
D083_RS16555	COG1773	rubredoxin
D083_RS16560	COG3604	Transcriptional regulator
D083_RS16565	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D083_RS16565	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D083_RS16590	COG3976	FMN-binding domain protein
D083_RS16590	COG1053	succinate dehydrogenase
D083_RS16590	COG0431	NADPH-dependent FMN reductase
D083_RS16595	COG0431	NADPH-dependent FMN reductase
D083_RS16595	COG3976	FMN-binding domain protein
D083_RS16595	COG1053	succinate dehydrogenase
D083_RS16600	COG0477	Major facilitator Superfamily
D083_RS16605	COG3301	Polysulphide reductase, NrfD
D083_RS16610	COG0437	4 iron, 4 sulfur cluster binding
D083_RS16625	COG1609	Transcriptional regulator
D083_RS16630	COG1234	tRNA 3'-trailer cleavage
D083_RS16635	COG3842	ATPase activity
D083_RS16645	COG1175	transmembrane transport
D083_RS16660	COG0473	3-isopropylmalate dehydrogenase activity
D083_RS16665	COG0583	DNA-binding transcription factor activity
D083_RS16670	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D083_RS16670	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D083_RS16690	COG2862	Uncharacterized protein family, UPF0114
D083_RS16725	COG0745	RESPONSE REGULATOR receiver
D083_RS16730	COG5002	protein histidine kinase activity
D083_RS16740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D083_RS16750	COG1733	regulation of RNA biosynthetic process
D083_RS16795	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D083_RS16805	COG0583	DNA-binding transcription factor activity
D083_RS16810	COG0577	efflux transmembrane transporter activity
D083_RS16810	COG1136	(ABC) transporter
D083_RS16820	COG0577	efflux transmembrane transporter activity
D083_RS16820	COG1136	(ABC) transporter
D083_RS16860	COG0534	Mate efflux family protein
D083_RS16880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D083_RS16885	COG0300	oxidoreductase activity
D083_RS16900	COG0667	Aldo Keto reductase
D083_RS16905	COG0604	alcohol dehydrogenase
D083_RS16925	COG1982	Orn Lys Arg decarboxylase major
D083_RS16935	COG0741	lytic transglycosylase activity
D083_RS16940	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D083_RS16950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D083_RS16955	COG3171	Protein conserved in bacteria
D083_RS16970	COG0667	Aldo Keto reductase
D083_RS16980	COG0861	Integral membrane protein TerC family
D083_RS16985	COG3066	DNA modification
D083_RS16995	COG0494	nUDIX hydrolase
D083_RS17005	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D083_RS17010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D083_RS17015	COG2165	general secretion pathway protein
D083_RS17020	COG4795	General secretion pathway protein
D083_RS17035	COG1025	Belongs to the peptidase M16 family
D083_RS17040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D083_RS17040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D083_RS17045	COG0860	N-Acetylmuramoyl-L-alanine amidase
D083_RS17060	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D083_RS17070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D083_RS17080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D083_RS17085	COG2166	iron-sulfur cluster assembly
D083_RS17090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D083_RS17095	COG0583	DNA-binding transcription factor activity
D083_RS17100	COG2363	Small membrane protein
D083_RS17105	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D083_RS17110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D083_RS17115	COG1611	Belongs to the LOG family
D083_RS17145	COG2171	N-acyltransferase activity
D083_RS17150	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D083_RS17165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D083_RS17170	COG0528	UMP kinase activity
D083_RS17175	COG0233	cytoplasmic translational termination
D083_RS17180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D083_RS17185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D083_RS17190	COG0575	Belongs to the CDS family
D083_RS17195	COG0750	zinc metalloprotease
D083_RS17200	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D083_RS17205	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D083_RS17210	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D083_RS17215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D083_RS17220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D083_RS17225	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D083_RS17230	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D083_RS17235	COG0587	DNA-directed DNA polymerase activity
D083_RS17240	COG0825	malonyl-CoA metabolic process
D083_RS17245	COG0346	lactoylglutathione lyase activity
D083_RS17250	COG0037	tRNA processing
D083_RS17255	COG4568	rho-dependent transcription termination
D083_RS17265	COG4681	YaeQ
D083_RS17270	COG3015	lipoprotein NlpE involved in copper resistance
D083_RS17275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D083_RS17295	COG0778	Nitroreductase
D083_RS17310	COG1881	PFAM PEBP family protein
D083_RS17340	COG2192	nodulation
D083_RS17365	COG2423	ornithine cyclodeaminase activity
D083_RS17375	COG0583	DNA-binding transcription factor activity
D083_RS17390	COG0546	phosphoglycolate phosphatase activity
D083_RS17405	COG2824	Alkylphosphonate utilization operon protein PhnA
D083_RS17410	COG3706	GGDEF domain
D083_RS17435	COG0583	DNA-binding transcription factor activity
D083_RS17460	COG0583	DNA-binding transcription factor activity
D083_RS17475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D083_RS17480	COG4615	Cyclic peptide transporter
D083_RS17495	COG3123	guanosine phosphorylase activity
D083_RS17500	COG0840	transmembrane signaling receptor activity
D083_RS17510	COG2974	May be involved in recombination
D083_RS17515	COG1940	carbohydrate kinase activity
D083_RS17520	COG0419	ATPase involved in DNA repair
D083_RS17525	COG0420	3'-5' exonuclease activity
D083_RS17535	COG5002	protein histidine kinase activity
D083_RS17545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D083_RS17560	COG0450	alkyl hydroperoxide reductase
D083_RS17565	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D083_RS17570	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D083_RS17575	COG0343	queuine tRNA-ribosyltransferase activity
D083_RS17580	COG1862	Preprotein translocase
D083_RS17585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D083_RS17590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D083_RS17595	COG4238	major outer membrane lipoprotein
D083_RS17600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D083_RS17605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D083_RS17610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D083_RS17610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D083_RS17615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D083_RS17620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D083_RS17625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D083_RS17630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D083_RS17635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D083_RS17640	COG0142	geranyltranstransferase activity
D083_RS17645	COG1722	exodeoxyribonuclease VII activity
D083_RS17650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D083_RS17650	COG0301	tRNA thio-modification
D083_RS17655	COG0693	protein deglycase activity
D083_RS17660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D083_RS17665	COG1666	GTP binding
D083_RS17675	COG2814	Major facilitator Superfamily
D083_RS17695	COG0109	protoheme IX farnesyltransferase activity
D083_RS17700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D083_RS17705	COG1845	cytochrome c oxidase, subunit III
D083_RS17710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D083_RS17715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D083_RS17720	COG2223	nitrite transmembrane transporter activity
D083_RS17725	COG3056	Lipoprotein
D083_RS17730	COG0271	Belongs to the BolA IbaG family
D083_RS17735	COG0544	peptidyl-prolyl cis-trans isomerase activity
D083_RS17740	COG0740	serine-type endopeptidase activity
D083_RS17745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D083_RS17750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D083_RS17755	COG0776	regulation of translation
D083_RS17760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D083_RS17765	COG1555	photosystem II stabilization
D083_RS17770	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D083_RS17780	COG1522	sequence-specific DNA binding
D083_RS17785	COG1132	(ABC) transporter
D083_RS17790	COG1132	(ABC) transporter
D083_RS17795	COG0347	Belongs to the P(II) protein family
D083_RS17800	COG0004	ammonium transporteR
D083_RS17805	COG1946	Acyl-CoA thioesterase
D083_RS17810	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D083_RS17815	COG3695	enzyme binding
D083_RS17835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D083_RS17840	COG0254	rRNA binding
D083_RS17845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D083_RS17850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D083_RS17855	COG1309	transcriptional regulator
D083_RS17860	COG3264	Mechanosensitive ion channel
D083_RS17860	COG1196	nuclear chromosome segregation
D083_RS17880	COG2832	Protein of unknown function (DUF454)
D083_RS17885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D083_RS17895	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D083_RS17900	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D083_RS17905	COG0326	Molecular chaperone. Has ATPase activity
D083_RS17910	COG0563	adenylate kinase activity
D083_RS17915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D083_RS17920	COG4651	solute:proton antiporter activity
D083_RS17920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D083_RS17925	COG0737	Belongs to the 5'-nucleotidase family
D083_RS17940	COG0840	transmembrane signaling receptor activity
D083_RS17955	COG3735	TraB family
D083_RS17960	COG2217	Heavy metal translocating P-type atpase
D083_RS17965	COG0789	Transcriptional regulator
D083_RS17970	COG1585	Membrane protein implicated in regulation of membrane protease activity
D083_RS17975	COG0330	HflC and HflK could
D083_RS17980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D083_RS17990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D083_RS17995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D083_RS18005	COG0784	Response regulator, receiver
D083_RS18005	COG2205	protein histidine kinase activity
D083_RS18015	COG2198	Histidine kinase
D083_RS18015	COG0642	Histidine kinase
D083_RS18020	COG2223	nitrite transmembrane transporter activity
D083_RS18025	COG1169	isochorismate synthase
D083_RS18030	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D083_RS18035	COG0596	Alpha beta hydrolase
D083_RS18040	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D083_RS18045	COG1441	menaquinone biosynthetic process
D083_RS18065	COG3118	belongs to the thioredoxin family
D083_RS18070	COG0300	oxidoreductase activity
D083_RS18075	COG2755	lipolytic protein G-D-S-L family
D083_RS18080	COG4181	ATPase activity
D083_RS18085	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D083_RS18095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D083_RS18100	COG0765	amino acid transport
D083_RS18105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D083_RS18120	COG1879	ABC-type sugar transport system periplasmic component
D083_RS18130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D083_RS18135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D083_RS18140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D083_RS18145	COG2233	PERMEase
D083_RS18150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D083_RS18155	COG1393	Belongs to the ArsC family
D083_RS18160	COG4783	chaperone-mediated protein folding
D083_RS18165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D083_RS18170	COG2716	regulation of RNA biosynthetic process
D083_RS18180	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D083_RS18185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D083_RS18190	COG2707	UPF0756 membrane protein
D083_RS18195	COG1444	tRNA N-acetyltransferase activity
D083_RS18200	COG0400	carboxylic ester hydrolase activity
D083_RS18210	COG1876	peptidase activity
D083_RS18215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D083_RS18220	COG1393	Belongs to the ArsC family
D083_RS18230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D083_RS18235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D083_RS18240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D083_RS18245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D083_RS18250	COG0321	lipoyl(octanoyl) transferase activity
D083_RS18255	COG2921	Belongs to the UPF0250 family
D083_RS18260	COG1686	Belongs to the peptidase S11 family
D083_RS18265	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D083_RS18270	COG0772	Belongs to the SEDS family
D083_RS18275	COG0768	penicillin binding
D083_RS18280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D083_RS18285	COG0799	negative regulation of ribosome biogenesis
D083_RS18290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D083_RS18295	COG1466	dna polymerase III delta subunit
D083_RS18300	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D083_RS18305	COG0495	leucyl-tRNA aminoacylation
D083_RS18310	COG2888	peptidyl-tyrosine sulfation
D083_RS18315	COG1126	abc transporter atp-binding protein
D083_RS18320	COG0765	amino acid transport
D083_RS18325	COG0765	amino acid transport
D083_RS18335	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D083_RS18340	COG4535	Mg2 and Co2 transporter CorC
D083_RS18345	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D083_RS18350	COG1702	phosphate starvation-inducible protein PhoH
D083_RS18355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D083_RS18360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D083_RS18405	COG0367	asparagine synthase
D083_RS18410	COG1940	carbohydrate kinase activity
D083_RS18410	COG1846	Transcriptional regulator
D083_RS18415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D083_RS18420	COG0363	glucosamine-6-phosphate deaminase activity
D083_RS18425	COG2190	(PTS) system
D083_RS18425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D083_RS18425	COG1263	PTS System
D083_RS18430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D083_RS18435	COG0735	belongs to the Fur family
D083_RS18445	COG0840	transmembrane signaling receptor activity
D083_RS18455	COG0596	Alpha beta hydrolase
D083_RS18460	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D083_RS18465	COG0033	Phosphoglucomutase
D083_RS18475	COG0745	RESPONSE REGULATOR receiver
D083_RS18480	COG2205	protein histidine kinase activity
D083_RS18485	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D083_RS18490	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D083_RS18495	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D083_RS18510	COG3272	Protein of unknown function (DUF1722)
D083_RS18515	COG0415	Belongs to the DNA photolyase family
D083_RS18520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D083_RS18525	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D083_RS18530	COG1984	allophanate hydrolase subunit 2
D083_RS18535	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D083_RS18540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D083_RS18545	COG0372	Belongs to the citrate synthase family
D083_RS18555	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D083_RS18560	COG1053	succinate dehydrogenase
D083_RS18565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D083_RS18570	COG0567	Dehydrogenase, E1 component
D083_RS18575	COG0508	dehydrogenase complex catalyzes the overall conversion of
D083_RS18585	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D083_RS18590	COG1271	oxidase subunit
D083_RS18595	COG1294	oxidase, subunit
D083_RS18600	COG4890	Cyd operon protein YbgT
D083_RS18605	COG3790	cyd operon protein YbgE
D083_RS18610	COG0824	Thioesterase
D083_RS18615	COG0811	peptide transport
D083_RS18620	COG0848	biopolymer transport protein
D083_RS18625	COG3064	Membrane
D083_RS18630	COG0823	Involved in the tonB-independent uptake of proteins
D083_RS18635	COG2885	chlorophyll binding
D083_RS18640	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D083_RS18665	COG1811	Na channel or pump
D083_RS18670	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D083_RS18680	COG1230	cation diffusion facilitator family transporter
D083_RS18685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D083_RS18690	COG0588	phosphoglycerate mutase activity
D083_RS18695	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D083_RS18700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D083_RS18720	COG2017	converts alpha-aldose to the beta-anomer
D083_RS18730	COG1085	galactose-1-phosphate uridylyltransferase
D083_RS18735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D083_RS18740	COG1119	ATPase activity
D083_RS18745	COG2005	Transcriptional regulator
D083_RS18745	COG3585	molybdate ion transport
D083_RS18755	COG0725	ABC transporter, periplasmic molybdate-binding protein
D083_RS18760	COG4149	molybdate abc transporter
D083_RS18765	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D083_RS18775	COG0561	phosphatase activity
D083_RS18780	COG2706	6-phosphogluconolactonase activity
D083_RS18800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D083_RS18800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D083_RS18805	COG0489	protein tyrosine kinase activity
D083_RS18815	COG0717	Belongs to the dCTP deaminase family
D083_RS18820	COG2982	Protein involved in outer membrane biogenesis
D083_RS18825	COG1253	flavin adenine dinucleotide binding
D083_RS18875	COG1088	dTDP-glucose 4,6-dehydratase activity
D083_RS18895	COG1215	transferase activity, transferring glycosyl groups
D083_RS18900	COG2244	polysaccharide biosynthetic process
D083_RS18930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D083_RS18960	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D083_RS18975	COG3706	GGDEF domain
D083_RS18995	COG2990	Protein conserved in bacteria
D083_RS19010	COG3720	iron ion transport
D083_RS19015	COG4558	Periplasmic binding protein
D083_RS19020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D083_RS19025	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D083_RS19035	COG2706	6-phosphogluconolactonase activity
D083_RS19040	COG0783	Belongs to the Dps family
D083_RS19045	COG2267	carboxylic ester hydrolase activity
D083_RS19065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS19070	COG0444	Belongs to the ABC transporter superfamily
D083_RS19075	COG4608	Belongs to the ABC transporter superfamily
D083_RS19085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D083_RS19095	COG3501	Rhs element vgr protein
D083_RS19120	COG3209	COG3209 Rhs family protein
D083_RS19155	COG1473	amidohydrolase
D083_RS19215	COG3829	transcription factor binding
D083_RS19255	COG4948	Mandelate Racemase Muconate Lactonizing
D083_RS19265	COG5001	Diguanylate cyclase
D083_RS19265	COG2203	Gaf domain
D083_RS19265	COG3706	GGDEF domain
D083_RS19265	COG4251	negative regulation of phosphorylation
D083_RS19270	COG0672	)-iron permease
D083_RS19285	COG3813	Protein conserved in bacteria
D083_RS19300	COG1136	(ABC) transporter
D083_RS19300	COG0577	efflux transmembrane transporter activity
D083_RS19320	COG3321	synthase
D083_RS19320	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D083_RS19320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D083_RS19325	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D083_RS19325	COG2070	2-Nitropropane dioxygenase
D083_RS19330	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS19360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D083_RS19385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D083_RS19390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D083_RS19395	COG0745	RESPONSE REGULATOR receiver
D083_RS19400	COG5002	protein histidine kinase activity
D083_RS19405	COG0583	DNA-binding transcription factor activity
D083_RS19435	COG0730	response to heat
D083_RS19440	COG0488	(ABC) transporter
D083_RS19455	COG1556	Lactate utilization protein
D083_RS19460	COG1139	Iron-sulfur cluster binding protein
D083_RS19465	COG0247	lactate metabolic process
D083_RS19470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D083_RS19485	COG1346	cytolysis
D083_RS19495	COG4566	intracellular signal transduction
D083_RS19500	COG4191	Histidine kinase
D083_RS19505	COG1116	anion transmembrane transporter activity
D083_RS19510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D083_RS19515	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D083_RS19520	COG0768	penicillin binding
D083_RS19525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D083_RS19530	COG0747	negative chemotaxis
D083_RS19535	COG0601	transmembrane transport
D083_RS19545	COG0444	Belongs to the ABC transporter superfamily
D083_RS19550	COG1124	(ABC) transporter
D083_RS19555	COG1846	Transcriptional regulator
D083_RS19560	COG1566	PFAM secretion protein HlyD family protein
D083_RS19565	COG2814	Major facilitator Superfamily
D083_RS19570	COG3708	Transcriptional regulator
D083_RS19570	COG2207	Transcriptional regulator
D083_RS19590	COG3615	Tellurite resistance protein tehB
D083_RS19600	COG2814	Major facilitator Superfamily
D083_RS19635	COG2207	Transcriptional regulator
D083_RS19640	COG2315	Protein conserved in bacteria
D083_RS19675	COG3250	beta-galactosidase activity
D083_RS19680	COG1609	Transcriptional regulator
D083_RS19690	COG0583	DNA-binding transcription factor activity
D083_RS19695	COG1301	dicarboxylic acid transport
D083_RS19705	COG3383	formate dehydrogenase (NAD+) activity
D083_RS19710	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D083_RS19725	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D083_RS19735	COG3260	NADH ubiquinone oxidoreductase 20
D083_RS19740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D083_RS19745	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
D083_RS19745	COG3261	NADH dehydrogenase
D083_RS19750	COG0651	ATP synthesis coupled electron transport
D083_RS19755	COG4237	Hydrogenase 4 membrane
D083_RS19760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D083_RS19765	COG0650	Formate hydrogenlyase subunit 4
D083_RS19770	COG0651	ATP synthesis coupled electron transport
D083_RS19775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D083_RS19780	COG0298	carbon dioxide binding
D083_RS19785	COG0697	spore germination
D083_RS19790	COG0583	DNA-binding transcription factor activity
D083_RS19795	COG1301	dicarboxylic acid transport
D083_RS19800	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D083_RS19810	COG0625	glutathione transferase activity
D083_RS19820	COG0583	DNA-binding transcription factor activity
D083_RS19830	COG1064	alcohol dehydrogenase
D083_RS19840	COG0667	Aldo Keto reductase
D083_RS19870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D083_RS19875	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D083_RS19885	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D083_RS19890	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D083_RS19900	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D083_RS19905	COG1012	belongs to the aldehyde dehydrogenase family
D083_RS19910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D083_RS19920	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS19925	COG0300	oxidoreductase activity
D083_RS19930	COG1752	Esterase of the alpha-beta hydrolase superfamily
D083_RS19935	COG0702	epimerase
D083_RS19955	COG2188	Transcriptional regulator
D083_RS19960	COG3624	Phosphonate C-P lyase system protein PhnG
D083_RS19965	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
D083_RS19970	COG3626	phosphonate metabolism
D083_RS19975	COG3627	carbon phosphorus lyase activity
D083_RS19980	COG4107	phosphonate C-P lyase system protein PhnK
D083_RS19985	COG4778	phosphonate C-P lyase system protein PhnL
D083_RS19990	COG3454	Phosphonate metabolism
D083_RS19995	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
D083_RS20000	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D083_RS20010	COG0583	DNA-binding transcription factor activity
D083_RS20020	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
D083_RS20035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D083_RS20050	COG0019	diaminopimelate decarboxylase activity
D083_RS20055	COG2814	Major facilitator Superfamily
D083_RS20060	COG4264	IucA IucC family
D083_RS20070	COG4264	IucA IucC family
D083_RS20080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D083_RS20085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D083_RS20090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D083_RS20095	COG1120	ATPase activity
D083_RS20100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D083_RS20105	COG1598	PFAM Uncharacterised protein family UPF0150
D083_RS20130	COG3383	formate dehydrogenase (NAD+) activity
D083_RS20130	COG0243	molybdopterin cofactor binding
D083_RS20135	COG0437	4 iron, 4 sulfur cluster binding
D083_RS20140	COG2864	formate dehydrogenase
D083_RS20160	COG2211	Major facilitator Superfamily
D083_RS20180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D083_RS20185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D083_RS20195	COG2199	diguanylate cyclase activity
D083_RS20200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D083_RS20245	COG3416	Protein conserved in bacteria
D083_RS20265	COG2011	ABC-type metal ion transport system permease component
D083_RS20270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D083_RS20300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D083_RS20305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D083_RS20325	COG2134	cdp-diacylglycerol pyrophosphatase
D083_RS20335	COG4166	transmembrane transport
D083_RS20340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D083_RS20345	COG1957	nucleoside hydrolase
D083_RS20355	COG0601	transmembrane transport
D083_RS20380	COG2964	Protein conserved in bacteria
D083_RS20390	COG0835	chemotaxis
D083_RS20390	COG0784	Response regulator, receiver
D083_RS20420	COG0679	Auxin Efflux Carrier
D083_RS20430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D083_RS20440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D083_RS20445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D083_RS20450	COG1121	(ABC) transporter
D083_RS20455	COG0803	Belongs to the bacterial solute-binding protein 9 family
D083_RS20465	COG0697	spore germination
D083_RS20470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D083_RS20480	COG1984	allophanate hydrolase subunit 2
D083_RS20485	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D083_RS20490	COG0436	Aminotransferase
D083_RS20505	COG4221	oxidoreductase activity
D083_RS20510	COG0765	amino acid transport
D083_RS20515	COG0765	amino acid transport
D083_RS20530	COG2186	Transcriptional regulator
D083_RS20535	COG3734	2-keto-3-deoxy-galactonokinase
D083_RS20540	COG0800	Aldolase
D083_RS20545	COG4948	Mandelate Racemase Muconate Lactonizing
D083_RS20550	COG2271	Major facilitator Superfamily
D083_RS20555	COG0583	DNA-binding transcription factor activity
D083_RS20560	COG1028	Short-chain dehydrogenase reductase Sdr
D083_RS20615	COG0582	viral genome integration into host DNA
D083_RS20655	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
D083_RS20665	COG3504	Conjugal transfer protein
D083_RS20710	COG2249	NAD(P)H dehydrogenase (quinone) activity
D083_RS20715	COG0667	Aldo Keto reductase
D083_RS20765	COG3423	Transcriptional regulator
D083_RS20770	COG1476	TRANSCRIPTIONal
D083_RS20780	COG3501	Rhs element vgr protein
D083_RS20815	COG5489	Protein of unknown function (DUF736)
D083_RS20830	COG3228	Belongs to the MtfA family
D083_RS20845	COG1396	sequence-specific DNA binding
D083_RS20850	COG0401	homolog of Blt101
D083_RS20860	COG0463	Glycosyl transferase, family 2
D083_RS20860	COG0457	Tetratricopeptide repeat
D083_RS20865	COG1607	acyl-coa hydrolase
D083_RS20870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D083_RS20875	COG0303	'Molybdopterin
D083_RS20880	COG0281	malic enzyme
D083_RS20885	COG0295	cytidine deaminase activity
D083_RS20895	COG1346	cytolysis
D083_RS20900	COG1380	Effector of murein hydrolase LrgA
D083_RS20915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D083_RS20920	COG0156	8-amino-7-oxononanoate synthase activity
D083_RS20925	COG2226	methyltransferase
D083_RS20930	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D083_RS20940	COG0556	nucleotide-excision repair
D083_RS20950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D083_RS20955	COG1271	oxidase subunit
D083_RS20960	COG1294	oxidase, subunit
D083_RS20970	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D083_RS20975	COG0521	Mo-molybdopterin cofactor biosynthetic process
D083_RS20985	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D083_RS21010	COG0670	Belongs to the BI1 family
D083_RS21020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D083_RS21025	COG3568	Endonuclease Exonuclease Phosphatase
D083_RS21030	COG0842	Transport permease protein
D083_RS21035	COG0842	Transport permease protein
D083_RS21040	COG1131	(ABC) transporter
D083_RS21045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D083_RS21050	COG0513	Belongs to the DEAD box helicase family
D083_RS21055	COG0697	spore germination
D083_RS21070	COG0444	Belongs to the ABC transporter superfamily
D083_RS21085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS21090	COG0584	glycerophosphoryl diester phosphodiesterase
D083_RS21100	COG2195	Cleaves the N-terminal amino acid of tripeptides
D083_RS21105	COG0747	negative chemotaxis
D083_RS21110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D083_RS21120	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D083_RS21125	COG1686	Belongs to the peptidase S11 family
D083_RS21135	COG1349	DNA-binding transcription factor activity
D083_RS21145	COG1472	Belongs to the glycosyl hydrolase 3 family
D083_RS21160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D083_RS21170	COG0671	phosphoesterase, PA-phosphatase related
D083_RS21175	COG0671	phosphoesterase, PA-phosphatase related
D083_RS21185	COG1126	abc transporter atp-binding protein
D083_RS21190	COG0765	amino acid transport
D083_RS21195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D083_RS21200	COG0783	Belongs to the Dps family
D083_RS21210	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D083_RS21215	COG1846	Transcriptional regulator
D083_RS21220	COG2807	transmembrane transport
D083_RS21225	COG0583	DNA-binding transcription factor activity
D083_RS21250	COG1984	allophanate hydrolase subunit 2
D083_RS21265	COG1136	(ABC) transporter
D083_RS21270	COG1136	(ABC) transporter
D083_RS21270	COG0577	efflux transmembrane transporter activity
D083_RS21285	COG4677	pectinesterase activity
D083_RS21290	COG3136	membrane protein required for alginate biosynthesis
D083_RS21305	COG0601	transmembrane transport
D083_RS21310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D083_RS21315	COG0444	Belongs to the ABC transporter superfamily
D083_RS21320	COG4608	Belongs to the ABC transporter superfamily
D083_RS21375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D083_RS21410	COG3082	Protein of unknown function (DUF1414)
D083_RS21415	COG3081	Nucleoid-associated protein
D083_RS21420	COG3275	phosphorelay sensor kinase activity
D083_RS21425	COG3279	Response regulator of the LytR AlgR family
D083_RS21430	COG2223	nitrite transmembrane transporter activity
D083_RS21435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D083_RS21440	COG1061	Type III restriction enzyme res subunit
D083_RS21455	COG2814	Major facilitator Superfamily
D083_RS21470	COG4172	Belongs to the ABC transporter superfamily
D083_RS21475	COG4239	(ABC) transporter, permease
D083_RS21480	COG4174	ABC transporter (Permease)
D083_RS21485	COG4166	transmembrane transport
D083_RS21490	COG0791	NLP P60 protein
D083_RS21495	COG0671	phosphoesterase, PA-phosphatase related
D083_RS21500	COG0523	cobalamin synthesis protein
D083_RS21505	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D083_RS21525	COG1105	Belongs to the carbohydrate kinase PfkB family
D083_RS21530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D083_RS21530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D083_RS21530	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D083_RS21540	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D083_RS21545	COG2855	membrane
D083_RS21550	COG0583	DNA-binding transcription factor activity
D083_RS21555	COG0833	amino acid
D083_RS21565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D083_RS21580	COG0508	dehydrogenase complex catalyzes the overall conversion of
D083_RS21590	COG1172	Belongs to the binding-protein-dependent transport system permease family
D083_RS21595	COG1129	ABC transporter
D083_RS21600	COG0371	Dehydrogenase
D083_RS21620	COG0583	DNA-binding transcription factor activity
D083_RS21625	COG0840	transmembrane signaling receptor activity
D083_RS21635	COG0840	transmembrane signaling receptor activity