locus-tag	class	description
C1O30_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1O30_RS00015	COG0592	DNA-directed DNA polymerase activity
C1O30_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1O30_RS00035	COG0742	ribosomal rna small subunit methyltransferase
C1O30_RS00040	COG0339	signal peptide processing
C1O30_RS00050	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C1O30_RS00055	COG1234	tRNA 3'-trailer cleavage
C1O30_RS00060	COG4650	regulator
C1O30_RS00070	COG1690	Belongs to the RtcB family
C1O30_RS00075	COG3541	Predicted nucleotidyltransferase
C1O30_RS00080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1O30_RS00130	COG1522	sequence-specific DNA binding
C1O30_RS00135	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1O30_RS00160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1O30_RS00165	COG4191	Histidine kinase
C1O30_RS00185	COG0583	DNA-binding transcription factor activity
C1O30_RS00205	COG0837	glucose binding
C1O30_RS00220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1O30_RS00240	COG0747	negative chemotaxis
C1O30_RS00250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1O30_RS00255	COG3977	Valine--pyruvate aminotransferase
C1O30_RS00265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1O30_RS00270	COG0456	acetyltransferase
C1O30_RS00275	COG2818	Glycosylase
C1O30_RS00290	COG0751	glycine-tRNA ligase activity
C1O30_RS00300	COG3842	ATPase activity
C1O30_RS00305	COG1940	carbohydrate kinase activity
C1O30_RS00310	COG1940	carbohydrate kinase activity
C1O30_RS00325	COG1175	transmembrane transport
C1O30_RS00330	COG0395	ABC-type sugar transport system, permease component
C1O30_RS00350	COG3842	ATPase activity
C1O30_RS00355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1O30_RS00370	COG2213	PTS system mannitol-specific
C1O30_RS00370	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1O30_RS00375	COG0246	Mannitol dehydrogenase
C1O30_RS00380	COG3722	fumarate hydratase activity
C1O30_RS00385	COG0840	transmembrane signaling receptor activity
C1O30_RS00395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1O30_RS00400	COG1012	belongs to the aldehyde dehydrogenase family
C1O30_RS00405	COG1070	Carbohydrate kinase
C1O30_RS00410	COG2115	Belongs to the xylose isomerase family
C1O30_RS00415	COG4213	ABC transporter substrate-binding protein
C1O30_RS00420	COG1129	ABC transporter
C1O30_RS00425	COG4214	carbohydrate transport
C1O30_RS00430	COG1609	Transcriptional regulator
C1O30_RS00430	COG2207	Transcriptional regulator
C1O30_RS00450	COG0137	argininosuccinate synthase activity
C1O30_RS00455	COG1846	Transcriptional regulator
C1O30_RS00460	COG0697	spore germination
C1O30_RS00465	COG2313	pseudouridylate synthase activity
C1O30_RS00475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1O30_RS00510	COG1136	(ABC) transporter
C1O30_RS00510	COG0577	efflux transmembrane transporter activity
C1O30_RS00515	COG0577	efflux transmembrane transporter activity
C1O30_RS00515	COG1136	(ABC) transporter
C1O30_RS00530	COG2091	lysine biosynthetic process via aminoadipic acid
C1O30_RS00540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1O30_RS00555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1O30_RS00575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1O30_RS00625	COG1561	YicC-like family, N-terminal region
C1O30_RS00630	COG0583	DNA-binding transcription factor activity
C1O30_RS00640	COG0747	negative chemotaxis
C1O30_RS00645	COG0601	transmembrane transport
C1O30_RS00650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O30_RS00655	COG0444	Belongs to the ABC transporter superfamily
C1O30_RS00660	COG4608	Belongs to the ABC transporter superfamily
C1O30_RS00685	COG0577	efflux transmembrane transporter activity
C1O30_RS00685	COG1136	(ABC) transporter
C1O30_RS00690	COG0577	efflux transmembrane transporter activity
C1O30_RS00690	COG1136	(ABC) transporter
C1O30_RS00735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O30_RS00740	COG0601	transmembrane transport
C1O30_RS00745	COG0747	negative chemotaxis
C1O30_RS00750	COG4172	Belongs to the ABC transporter superfamily
C1O30_RS00755	COG4948	Mandelate Racemase Muconate Lactonizing
C1O30_RS00770	COG2149	membrane
C1O30_RS00775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1O30_RS00780	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1O30_RS00785	COG1309	transcriptional regulator
C1O30_RS00790	COG0756	dUTP diphosphatase activity
C1O30_RS00795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1O30_RS00805	COG2003	Belongs to the UPF0758 family
C1O30_RS00820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1O30_RS00825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1O30_RS00835	COG1519	Transferase
C1O30_RS00840	COG0438	transferase activity, transferring glycosyl groups
C1O30_RS00855	COG0438	transferase activity, transferring glycosyl groups
C1O30_RS00860	COG0859	PFAM glycosyl transferase family 9
C1O30_RS00865	COG0859	PFAM glycosyl transferase family 9
C1O30_RS00870	COG0859	PFAM glycosyl transferase family 9
C1O30_RS00875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O30_RS00880	COG0156	8-amino-7-oxononanoate synthase activity
C1O30_RS00885	COG1063	alcohol dehydrogenase
C1O30_RS00890	COG2861	carbohydrate metabolic process
C1O30_RS00895	COG4942	peptidase
C1O30_RS00900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1O30_RS00910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1O30_RS00915	COG1045	serine acetyltransferase
C1O30_RS00930	COG0583	DNA-binding transcription factor activity
C1O30_RS00935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1O30_RS00940	COG0412	Dienelactone hydrolase
C1O30_RS00945	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C1O30_RS00955	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1O30_RS00960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1O30_RS00965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1O30_RS00970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1O30_RS00975	COG0165	Argininosuccinate lyase
C1O30_RS00985	COG1322	Protein conserved in bacteria
C1O30_RS00990	COG2226	methyltransferase
C1O30_RS00995	COG3165	ubiquinone biosynthetic process from chorismate
C1O30_RS01000	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1O30_RS01005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1O30_RS01010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1O30_RS01015	COG0805	protein transport
C1O30_RS01020	COG0084	hydrolase, TatD family'
C1O30_RS01035	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C1O30_RS01050	COG0183	Belongs to the thiolase family
C1O30_RS01055	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1O30_RS01055	COG1024	Enoyl-CoA hydratase
C1O30_RS01060	COG0006	proline dipeptidase activity
C1O30_RS01065	COG1739	Uncharacterized protein family UPF0029
C1O30_RS01070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1O30_RS01100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1O30_RS01110	COG1072	(Pantothenic acid kinase))
C1O30_RS01135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1O30_RS01145	COG0250	Participates in transcription elongation, termination and antitermination
C1O30_RS01180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1O30_RS01200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1O30_RS01205	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1O30_RS01210	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
C1O30_RS01235	COG2022	thiamine diphosphate biosynthetic process
C1O30_RS01240	COG2104	thiamine diphosphate biosynthetic process
C1O30_RS01245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1O30_RS01250	COG0352	thiamine-phosphate diphosphorylase activity
C1O30_RS01255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1O30_RS01260	COG2816	NAD+ diphosphatase activity
C1O30_RS01265	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1O30_RS01270	COG1515	deoxyribonuclease V activity
C1O30_RS01290	COG3385	transposase activity
C1O30_RS01295	COG0151	Belongs to the GarS family
C1O30_RS01330	COG1126	abc transporter atp-binding protein
C1O30_RS01335	COG0765	amino acid transport
C1O30_RS01340	COG4597	amino acid ABC transporter
C1O30_RS01345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1O30_RS01350	COG0504	CTP synthase activity
C1O30_RS01355	COG0765	amino acid transport
C1O30_RS01360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1O30_RS01370	COG3302	dmso reductase anchor subunit
C1O30_RS01380	COG0243	molybdopterin cofactor binding
C1O30_RS01390	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS01395	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C1O30_RS01405	COG2264	protein methyltransferase activity
C1O30_RS01410	COG4145	pantothenate transmembrane transporter activity
C1O30_RS01415	COG3924	membrane
C1O30_RS01420	COG0439	Biotin carboxylase
C1O30_RS01425	COG0511	ligase activity, forming carbon-carbon bonds
C1O30_RS01430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1O30_RS01435	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C1O30_RS01440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1O30_RS01445	COG0604	alcohol dehydrogenase
C1O30_RS01450	COG2200	EAL domain
C1O30_RS01450	COG2199	diguanylate cyclase activity
C1O30_RS01455	COG1077	Cell shape determining protein MreB Mrl
C1O30_RS01460	COG1792	Involved in formation and maintenance of cell shape
C1O30_RS01465	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C1O30_RS01470	COG0424	maF-like protein
C1O30_RS01480	COG3164	Protein of unknown function
C1O30_RS01485	COG0312	modulator of DNA gyrase
C1O30_RS01490	COG0583	DNA-binding transcription factor activity
C1O30_RS01500	COG1566	PFAM secretion protein HlyD family protein
C1O30_RS01505	COG1289	transmembrane transporter activity
C1O30_RS01515	COG1280	lysine exporter protein (LysE YggA)
C1O30_RS01520	COG3028	Belongs to the UPF0307 family
C1O30_RS01525	COG0312	modulator of DNA gyrase
C1O30_RS01530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1O30_RS01535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1O30_RS01555	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C1O30_RS01560	COG1137	ATPase activity
C1O30_RS01565	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C1O30_RS01570	COG3117	lipopolysaccharide transmembrane transporter activity
C1O30_RS01575	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C1O30_RS01580	COG0517	IMP dehydrogenase activity
C1O30_RS01580	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C1O30_RS01585	COG0530	calcium, potassium:sodium antiporter activity
C1O30_RS01590	COG1127	ABC transporter
C1O30_RS01595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1O30_RS01600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1O30_RS01605	COG2854	intermembrane phospholipid transfer
C1O30_RS01610	COG3113	response to antibiotic
C1O30_RS01615	COG5007	Belongs to the BolA IbaG family
C1O30_RS01620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1O30_RS01625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O30_RS01630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O30_RS01635	COG3105	Protein conserved in bacteria
C1O30_RS01640	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1O30_RS01655	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1O30_RS01660	COG0625	glutathione transferase activity
C1O30_RS01665	COG2969	positive regulation of protein catabolic process
C1O30_RS01670	COG3385	transposase activity
C1O30_RS01680	COG0493	'glutamate synthase
C1O30_RS01685	COG0070	glutamate synthase
C1O30_RS01685	COG0069	glutamate synthase activity
C1O30_RS01685	COG0067	glutamate synthase
C1O30_RS01690	COG1242	4 iron, 4 sulfur cluster binding
C1O30_RS01695	COG0784	Response regulator, receiver
C1O30_RS01695	COG2198	Histidine kinase
C1O30_RS01695	COG5002	protein histidine kinase activity
C1O30_RS01700	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C1O30_RS01705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1O30_RS01715	COG2823	Periplasmic or secreted lipoprotein
C1O30_RS01720	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1O30_RS01725	COG0792	nuclease activity
C1O30_RS01730	COG3107	peptidoglycan biosynthetic process
C1O30_RS01735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1O30_RS01745	COG3384	dioxygenase
C1O30_RS01750	COG0754	glutathionylspermidine amidase activity
C1O30_RS01755	COG5463	Belongs to the UPF0441 family
C1O30_RS01760	COG1538	Outer membrane efflux protein
C1O30_RS01765	COG0494	nUDIX hydrolase
C1O30_RS01770	COG3151	Protein conserved in bacteria
C1O30_RS01775	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1O30_RS01780	COG3150	esterase
C1O30_RS01795	COG0583	DNA-binding transcription factor activity
C1O30_RS01800	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1O30_RS01805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1O30_RS01815	COG2132	Multicopper oxidase
C1O30_RS01820	COG0656	L-ascorbic acid biosynthetic process
C1O30_RS01825	COG1979	alcohol dehydrogenase
C1O30_RS01830	COG0778	Nitroreductase
C1O30_RS01835	COG2207	Transcriptional regulator
C1O30_RS01840	COG0586	Pfam SNARE associated Golgi protein
C1O30_RS01845	COG0626	cystathionine gamma-synthase activity
C1O30_RS01850	COG0811	peptide transport
C1O30_RS01855	COG0848	biopolymer transport protein
C1O30_RS01885	COG1203	CRISPR-associated helicase, Cas3
C1O30_RS01900	COG1857	crispr-associated protein
C1O30_RS01915	COG1518	maintenance of DNA repeat elements
C1O30_RS01920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1O30_RS01940	COG1328	CTP reductase activity
C1O30_RS01955	COG0601	transmembrane transport
C1O30_RS01960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O30_RS01965	COG4172	Belongs to the ABC transporter superfamily
C1O30_RS01985	COG2308	Evidence 4 Homologs of previously reported genes of
C1O30_RS02000	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C1O30_RS02005	COG0540	Belongs to the ATCase OTCase family
C1O30_RS02010	COG2731	YhcH YjgK YiaL family protein
C1O30_RS02015	COG2723	6-phospho-beta-galactosidase activity
C1O30_RS02020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1O30_RS02030	COG0456	acetyltransferase
C1O30_RS02040	COG0454	-acetyltransferase
C1O30_RS02045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1O30_RS02050	COG0840	transmembrane signaling receptor activity
C1O30_RS02055	COG0525	valine-tRNA ligase activity
C1O30_RS02060	COG2927	DNA polymerase III (CHI subunit)
C1O30_RS02065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1O30_RS02070	COG0795	lipopolysaccharide-transporting ATPase activity
C1O30_RS02075	COG0795	lipopolysaccharide-transporting ATPase activity
C1O30_RS02110	COG3706	GGDEF domain
C1O30_RS02115	COG4106	trans-aconitate 2-methyltransferase activity
C1O30_RS02145	COG1522	sequence-specific DNA binding
C1O30_RS02175	COG3727	T/G mismatch-specific endonuclease activity
C1O30_RS02190	COG2814	Major facilitator Superfamily
C1O30_RS02205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1O30_RS02210	COG1349	DNA-binding transcription factor activity
C1O30_RS02215	COG3959	Transketolase, thiamine diphosphate binding domain
C1O30_RS02220	COG3958	Transketolase
C1O30_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS02230	COG1879	ABC-type sugar transport system periplasmic component
C1O30_RS02240	COG1129	ABC transporter
C1O30_RS02245	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1O30_RS02250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1O30_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS02260	COG0747	negative chemotaxis
C1O30_RS02270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O30_RS02275	COG0444	Belongs to the ABC transporter superfamily
C1O30_RS02280	COG4608	Belongs to the ABC transporter superfamily
C1O30_RS02295	COG0583	DNA-binding transcription factor activity
C1O30_RS02310	COG1605	Chorismate mutase
C1O30_RS02320	COG1418	mRNA catabolic process
C1O30_RS02325	COG1414	Transcriptional regulator
C1O30_RS02330	COG0840	transmembrane signaling receptor activity
C1O30_RS02340	COG3254	rhamnose metabolic process
C1O30_RS02345	COG0235	Class ii aldolase
C1O30_RS02350	COG4806	L-rhamnose isomerase
C1O30_RS02355	COG1070	Carbohydrate kinase
C1O30_RS02360	COG1917	Cupin 2, conserved barrel domain protein
C1O30_RS02360	COG2169	Transcriptional regulator
C1O30_RS02365	COG4977	sequence-specific DNA binding
C1O30_RS02365	COG1917	Cupin 2, conserved barrel domain protein
C1O30_RS02385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O30_RS02395	COG0747	negative chemotaxis
C1O30_RS02400	COG3477	response to acidic pH
C1O30_RS02405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1O30_RS02410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1O30_RS02415	COG0006	proline dipeptidase activity
C1O30_RS02420	COG3079	Belongs to the UPF0149 family
C1O30_RS02425	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C1O30_RS02435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1O30_RS02450	COG0560	Phosphoserine phosphatase
C1O30_RS02455	COG3726	membrane protein affecting hemolysin expression
C1O30_RS02460	COG4106	trans-aconitate 2-methyltransferase activity
C1O30_RS02470	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C1O30_RS02475	COG2823	Periplasmic or secreted lipoprotein
C1O30_RS02485	COG0084	hydrolase, TatD family'
C1O30_RS02490	COG2977	Belongs to the P-Pant transferase superfamily
C1O30_RS02495	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C1O30_RS02500	COG0840	transmembrane signaling receptor activity
C1O30_RS02520	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C1O30_RS02530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1O30_RS02540	COG3634	alkyl hydroperoxide reductase activity
C1O30_RS02555	COG0110	maltose O-acetyltransferase activity
C1O30_RS02575	COG1609	Transcriptional regulator
C1O30_RS02625	COG0297	glycogen (starch) synthase activity
C1O30_RS02625	COG0438	transferase activity, transferring glycosyl groups
C1O30_RS02640	COG1045	serine acetyltransferase
C1O30_RS02675	COG1309	transcriptional regulator
C1O30_RS02680	COG4232	protein-disulfide reductase activity
C1O30_RS02685	COG1324	tolerance protein
C1O30_RS02690	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1O30_RS02705	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1O30_RS02710	COG0459	protein refolding
C1O30_RS02715	COG3161	chorismate lyase activity
C1O30_RS02720	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1O30_RS02725	COG2937	Belongs to the GPAT DAPAT family
C1O30_RS02730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1O30_RS02735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1O30_RS02740	COG0735	belongs to the Fur family
C1O30_RS02745	COG1741	Belongs to the pirin family
C1O30_RS02750	COG0583	DNA-binding transcription factor activity
C1O30_RS02755	COG0435	Glutathione S-transferase
C1O30_RS02760	COG2259	Doxx family
C1O30_RS02770	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C1O30_RS02775	COG4575	ribosome binding
C1O30_RS02785	COG0586	Pfam SNARE associated Golgi protein
C1O30_RS02795	COG2271	Major facilitator Superfamily
C1O30_RS02800	COG1904	glucuronate isomerase
C1O30_RS02805	COG0246	Mannitol dehydrogenase
C1O30_RS02810	COG2721	sulfolactate sulfo-lyase activity
C1O30_RS02820	COG0861	Integral membrane protein TerC family
C1O30_RS02825	COG2813	Specifically methylates the guanine in position
C1O30_RS02840	COG2197	response regulator
C1O30_RS02850	COG2271	Major facilitator Superfamily
C1O30_RS02860	COG3678	ATP-independent chaperone mediated protein folding
C1O30_RS02865	COG1477	protein flavinylation
C1O30_RS02885	COG3385	transposase activity
C1O30_RS02910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1O30_RS02915	COG0358	DNA primase activity
C1O30_RS02920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1O30_RS02925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1O30_RS02930	COG1438	arginine binding
C1O30_RS02940	COG3423	Transcriptional regulator
C1O30_RS02955	COG0142	geranyltranstransferase activity
C1O30_RS02960	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1O30_RS02970	COG0697	spore germination
C1O30_RS02975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1O30_RS02980	COG2027	D-alanyl-D-alanine carboxypeptidase
C1O30_RS02990	COG1534	Rna-binding protein
C1O30_RS02995	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C1O30_RS03000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1O30_RS03005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1O30_RS03010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1O30_RS03015	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1O30_RS03030	COG0779	Required for maturation of 30S ribosomal subunits
C1O30_RS03035	COG0195	Participates in both transcription termination and antitermination
C1O30_RS03040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1O30_RS03045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1O30_RS03050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1O30_RS03055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1O30_RS03060	COG1185	polyribonucleotide nucleotidyltransferase activity
C1O30_RS03070	COG0513	Belongs to the DEAD box helicase family
C1O30_RS03075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1O30_RS03080	COG0826	peptidase U32
C1O30_RS03085	COG0826	peptidase U32
C1O30_RS03090	COG3154	lipid carrier protein
C1O30_RS03095	COG3153	acetyltransferase
C1O30_RS03100	COG2827	Endonuclease containing a URI domain
C1O30_RS03105	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1O30_RS03110	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C1O30_RS03115	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C1O30_RS03120	COG0813	purine-nucleoside phosphorylase activity
C1O30_RS03130	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C1O30_RS03135	COG2813	Specifically methylates the guanine in position
C1O30_RS03140	COG0667	Aldo Keto reductase
C1O30_RS03145	COG0583	DNA-binding transcription factor activity
C1O30_RS03185	COG1454	alcohol dehydrogenase
C1O30_RS03190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1O30_RS03195	COG0509	glycine decarboxylation via glycine cleavage system
C1O30_RS03200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1O30_RS03200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1O30_RS03210	COG1272	protein, Hemolysin III
C1O30_RS03215	COG0354	folic acid binding
C1O30_RS03220	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C1O30_RS03230	COG0716	FMN binding
C1O30_RS03235	COG0477	Major facilitator Superfamily
C1O30_RS03240	COG4974	Belongs to the 'phage' integrase family
C1O30_RS03245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1O30_RS03250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1O30_RS03275	COG1733	regulation of RNA biosynthetic process
C1O30_RS03280	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1O30_RS03305	COG0438	transferase activity, transferring glycosyl groups
C1O30_RS03330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1O30_RS03340	COG3842	ATPase activity
C1O30_RS03345	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1O30_RS03350	COG0395	ABC-type sugar transport system, permease component
C1O30_RS03355	COG1175	transmembrane transport
C1O30_RS03365	COG1560	Kdo2-lipid A biosynthetic process
C1O30_RS03375	COG2252	PERMEase
C1O30_RS03380	COG0025	NhaP-type Na H and K H
C1O30_RS03385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1O30_RS03390	COG3162	membrane
C1O30_RS03395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1O30_RS03410	COG2211	Major facilitator Superfamily
C1O30_RS03415	COG3655	Transcriptional regulator
C1O30_RS03420	COG0246	Mannitol dehydrogenase
C1O30_RS03425	COG2814	Major facilitator Superfamily
C1O30_RS03440	COG1376	ErfK ybiS ycfS ynhG family protein
C1O30_RS03445	COG1013	pyruvate-flavodoxin oxidoreductase activity
C1O30_RS03445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O30_RS03445	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C1O30_RS03445	COG0674	pyruvate-flavodoxin oxidoreductase activity
C1O30_RS03490	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1O30_RS03505	COG3962	Belongs to the TPP enzyme family
C1O30_RS03510	COG0673	inositol 2-dehydrogenase activity
C1O30_RS03525	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1O30_RS03530	COG0673	inositol 2-dehydrogenase activity
C1O30_RS03535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1O30_RS03545	COG3718	enzyme involved in inositol metabolism
C1O30_RS03550	COG2951	lytic endotransglycosylase activity
C1O30_RS03565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1O30_RS03600	COG3423	Transcriptional regulator
C1O30_RS03610	COG3501	Rhs element vgr protein
C1O30_RS03640	COG3829	transcription factor binding
C1O30_RS03770	COG2171	N-acyltransferase activity
C1O30_RS03935	COG3621	Patatin-like phospholipase
C1O30_RS03975	COG0270	DNA (cytosine-5-)-methyltransferase activity
C1O30_RS03980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1O30_RS04045	COG0582	viral genome integration into host DNA
C1O30_RS04060	COG2867	negative regulation of translational initiation
C1O30_RS04065	COG2914	Belongs to the UPF0125 (RnfH) family
C1O30_RS04075	COG0497	DNA recombination
C1O30_RS04080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1O30_RS04090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1O30_RS04095	COG1914	H( )-stimulated, divalent metal cation uptake system
C1O30_RS04100	COG0494	nUDIX hydrolase
C1O30_RS04105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1O30_RS04115	COG1671	Belongs to the UPF0178 family
C1O30_RS04120	COG0408	coproporphyrinogen oxidase activity
C1O30_RS04125	COG0456	acetyltransferase
C1O30_RS04130	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C1O30_RS04135	COG4771	TonB-dependent receptor
C1O30_RS04140	COG0612	Peptidase, M16
C1O30_RS04145	COG4178	(ABC) transporter
C1O30_RS04160	COG0738	Major facilitator superfamily
C1O30_RS04165	COG0583	DNA-binding transcription factor activity
C1O30_RS04170	COG2271	Major facilitator Superfamily
C1O30_RS04185	COG4670	ketone body catabolic process
C1O30_RS04190	COG1960	acyl-CoA dehydrogenase activity
C1O30_RS04195	COG2207	Transcriptional regulator
C1O30_RS04195	COG1917	Cupin 2, conserved barrel domain protein
C1O30_RS04200	COG2086	electron transfer activity
C1O30_RS04205	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C1O30_RS04210	COG0644	oxidoreductase
C1O30_RS04215	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C1O30_RS04220	COG0318	PFAM AMP-dependent synthetase and ligase
C1O30_RS04225	COG3423	Transcriptional regulator
C1O30_RS04240	COG2837	iron assimilation
C1O30_RS04245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1O30_RS04250	COG1136	(ABC) transporter
C1O30_RS04250	COG0577	efflux transmembrane transporter activity
C1O30_RS04255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O30_RS04260	COG0745	RESPONSE REGULATOR receiver
C1O30_RS04265	COG2205	protein histidine kinase activity
C1O30_RS04280	COG2190	(PTS) system
C1O30_RS04290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1O30_RS04300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1O30_RS04305	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C1O30_RS04310	COG3115	cell septum assembly
C1O30_RS04315	COG0531	amino acid
C1O30_RS04325	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1O30_RS04335	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1O30_RS04340	COG1773	rubredoxin
C1O30_RS04340	COG0426	domain, Protein
C1O30_RS04345	COG3604	Transcriptional regulator
C1O30_RS04350	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C1O30_RS04350	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C1O30_RS04380	COG3976	FMN-binding domain protein
C1O30_RS04380	COG1053	succinate dehydrogenase
C1O30_RS04380	COG0431	NADPH-dependent FMN reductase
C1O30_RS04385	COG0477	Major facilitator Superfamily
C1O30_RS04390	COG3301	Polysulphide reductase, NrfD
C1O30_RS04395	COG0437	4 iron, 4 sulfur cluster binding
C1O30_RS04400	COG0657	acetylesterase activity
C1O30_RS04410	COG1609	Transcriptional regulator
C1O30_RS04415	COG1234	tRNA 3'-trailer cleavage
C1O30_RS04420	COG3842	ATPase activity
C1O30_RS04425	COG0395	ABC-type sugar transport system, permease component
C1O30_RS04430	COG1175	transmembrane transport
C1O30_RS04450	COG0473	3-isopropylmalate dehydrogenase activity
C1O30_RS04455	COG0583	DNA-binding transcription factor activity
C1O30_RS04460	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1O30_RS04460	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1O30_RS04475	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS04495	COG2862	Uncharacterized protein family, UPF0114
C1O30_RS04515	COG0730	response to heat
C1O30_RS04535	COG0745	RESPONSE REGULATOR receiver
C1O30_RS04540	COG5002	protein histidine kinase activity
C1O30_RS04545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O30_RS04560	COG1733	regulation of RNA biosynthetic process
C1O30_RS04570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1O30_RS04590	COG2003	Belongs to the UPF0758 family
C1O30_RS04655	COG1982	Orn Lys Arg decarboxylase major
C1O30_RS04665	COG0741	lytic transglycosylase activity
C1O30_RS04680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1O30_RS04685	COG3171	Protein conserved in bacteria
C1O30_RS04695	COG1404	Belongs to the peptidase S8 family
C1O30_RS04700	COG0667	Aldo Keto reductase
C1O30_RS04710	COG0861	Integral membrane protein TerC family
C1O30_RS04715	COG3066	DNA modification
C1O30_RS04725	COG0494	nUDIX hydrolase
C1O30_RS04735	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1O30_RS04740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C1O30_RS04750	COG4795	General secretion pathway protein
C1O30_RS04770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1O30_RS04770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1O30_RS04775	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1O30_RS04790	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C1O30_RS04805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1O30_RS04815	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C1O30_RS04820	COG2166	iron-sulfur cluster assembly
C1O30_RS04825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1O30_RS04835	COG0583	DNA-binding transcription factor activity
C1O30_RS04840	COG2363	Small membrane protein
C1O30_RS04845	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C1O30_RS04850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1O30_RS04855	COG1611	Belongs to the LOG family
C1O30_RS04885	COG2171	N-acyltransferase activity
C1O30_RS04890	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C1O30_RS04905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1O30_RS04910	COG0528	UMP kinase activity
C1O30_RS04915	COG0233	cytoplasmic translational termination
C1O30_RS04920	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1O30_RS04925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1O30_RS04930	COG0575	Belongs to the CDS family
C1O30_RS04935	COG0750	zinc metalloprotease
C1O30_RS04940	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1O30_RS04945	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C1O30_RS04950	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1O30_RS04955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1O30_RS04960	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1O30_RS04965	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1O30_RS04970	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1O30_RS04975	COG0587	DNA-directed DNA polymerase activity
C1O30_RS04980	COG0825	malonyl-CoA metabolic process
C1O30_RS04985	COG0346	lactoylglutathione lyase activity
C1O30_RS04990	COG0037	tRNA processing
C1O30_RS04995	COG4568	rho-dependent transcription termination
C1O30_RS05005	COG4681	YaeQ
C1O30_RS05010	COG3015	lipoprotein NlpE involved in copper resistance
C1O30_RS05015	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1O30_RS05045	COG2124	cytochrome p450
C1O30_RS05075	COG3433	isochorismatase activity
C1O30_RS05075	COG2226	methyltransferase
C1O30_RS05075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1O30_RS05080	COG0318	PFAM AMP-dependent synthetase and ligase
C1O30_RS05105	COG0840	transmembrane signaling receptor activity
C1O30_RS05130	COG1881	PFAM PEBP family protein
C1O30_RS05160	COG2192	nodulation
C1O30_RS05195	COG0583	DNA-binding transcription factor activity
C1O30_RS05205	COG2824	Alkylphosphonate utilization operon protein PhnA
C1O30_RS05210	COG3706	GGDEF domain
C1O30_RS05250	COG0583	DNA-binding transcription factor activity
C1O30_RS05260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1O30_RS05275	COG3123	guanosine phosphorylase activity
C1O30_RS05280	COG0840	transmembrane signaling receptor activity
C1O30_RS05285	COG2974	May be involved in recombination
C1O30_RS05290	COG1940	carbohydrate kinase activity
C1O30_RS05295	COG0419	ATPase involved in DNA repair
C1O30_RS05300	COG0420	3'-5' exonuclease activity
C1O30_RS05310	COG5002	protein histidine kinase activity
C1O30_RS05320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1O30_RS05335	COG0450	alkyl hydroperoxide reductase
C1O30_RS05340	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C1O30_RS05345	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1O30_RS05350	COG0343	queuine tRNA-ribosyltransferase activity
C1O30_RS05355	COG1862	Preprotein translocase
C1O30_RS05360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1O30_RS05365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1O30_RS05375	COG3385	transposase activity
C1O30_RS05385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C1O30_RS05390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1O30_RS05395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1O30_RS05395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1O30_RS05400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1O30_RS05405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1O30_RS05410	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C1O30_RS05415	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1O30_RS05420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1O30_RS05425	COG0142	geranyltranstransferase activity
C1O30_RS05430	COG1722	exodeoxyribonuclease VII activity
C1O30_RS05435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1O30_RS05435	COG0301	tRNA thio-modification
C1O30_RS05440	COG0693	protein deglycase activity
C1O30_RS05445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1O30_RS05450	COG1666	GTP binding
C1O30_RS05455	COG2814	Major facilitator Superfamily
C1O30_RS05460	COG0109	protoheme IX farnesyltransferase activity
C1O30_RS05465	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C1O30_RS05470	COG1845	cytochrome c oxidase, subunit III
C1O30_RS05475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1O30_RS05480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1O30_RS05485	COG2223	nitrite transmembrane transporter activity
C1O30_RS05490	COG3056	Lipoprotein
C1O30_RS05495	COG0271	Belongs to the BolA IbaG family
C1O30_RS05500	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1O30_RS05510	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1O30_RS05515	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1O30_RS05520	COG0776	regulation of translation
C1O30_RS05525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1O30_RS05530	COG1555	photosystem II stabilization
C1O30_RS05535	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1O30_RS05545	COG1522	sequence-specific DNA binding
C1O30_RS05550	COG1132	(ABC) transporter
C1O30_RS05555	COG1132	(ABC) transporter
C1O30_RS05560	COG0347	Belongs to the P(II) protein family
C1O30_RS05565	COG0004	ammonium transporteR
C1O30_RS05570	COG1946	Acyl-CoA thioesterase
C1O30_RS05575	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C1O30_RS05580	COG3695	enzyme binding
C1O30_RS05600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1O30_RS05605	COG0254	rRNA binding
C1O30_RS05610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1O30_RS05615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O30_RS05620	COG1309	transcriptional regulator
C1O30_RS05625	COG3264	Mechanosensitive ion channel
C1O30_RS05625	COG1196	nuclear chromosome segregation
C1O30_RS05645	COG2832	Protein of unknown function (DUF454)
C1O30_RS05650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1O30_RS05655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1O30_RS05660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1O30_RS05665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1O30_RS05670	COG0326	Molecular chaperone. Has ATPase activity
C1O30_RS05675	COG0563	adenylate kinase activity
C1O30_RS05680	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1O30_RS05685	COG4651	solute:proton antiporter activity
C1O30_RS05685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1O30_RS05690	COG0737	Belongs to the 5'-nucleotidase family
C1O30_RS05700	COG0840	transmembrane signaling receptor activity
C1O30_RS05720	COG3735	TraB family
C1O30_RS05725	COG2217	Heavy metal translocating P-type atpase
C1O30_RS05735	COG1585	Membrane protein implicated in regulation of membrane protease activity
C1O30_RS05740	COG0330	HflC and HflK could
C1O30_RS05745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1O30_RS05750	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1O30_RS05755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1O30_RS05760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1O30_RS05770	COG2205	protein histidine kinase activity
C1O30_RS05770	COG0784	Response regulator, receiver
C1O30_RS05780	COG0642	Histidine kinase
C1O30_RS05780	COG2198	Histidine kinase
C1O30_RS05785	COG1169	isochorismate synthase
C1O30_RS05790	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1O30_RS05795	COG0596	Alpha beta hydrolase
C1O30_RS05800	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1O30_RS05805	COG1441	menaquinone biosynthetic process
C1O30_RS05830	COG3118	belongs to the thioredoxin family
C1O30_RS05835	COG0300	oxidoreductase activity
C1O30_RS05840	COG2755	lipolytic protein G-D-S-L family
C1O30_RS05845	COG4181	ATPase activity
C1O30_RS05850	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C1O30_RS05860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1O30_RS05865	COG0765	amino acid transport
C1O30_RS05870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1O30_RS05880	COG1129	ABC transporter
C1O30_RS05900	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1O30_RS05905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1O30_RS05910	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1O30_RS05915	COG2233	PERMEase
C1O30_RS05920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1O30_RS05925	COG1393	Belongs to the ArsC family
C1O30_RS05930	COG4783	chaperone-mediated protein folding
C1O30_RS05935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1O30_RS05940	COG2716	regulation of RNA biosynthetic process
C1O30_RS05950	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C1O30_RS05955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1O30_RS05960	COG2707	UPF0756 membrane protein
C1O30_RS05965	COG1444	tRNA N-acetyltransferase activity
C1O30_RS05970	COG0400	carboxylic ester hydrolase activity
C1O30_RS05980	COG1876	peptidase activity
C1O30_RS05985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1O30_RS05990	COG1393	Belongs to the ArsC family
C1O30_RS06000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1O30_RS06005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1O30_RS06010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1O30_RS06015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1O30_RS06020	COG0321	lipoyl(octanoyl) transferase activity
C1O30_RS06025	COG2921	Belongs to the UPF0250 family
C1O30_RS06030	COG1686	Belongs to the peptidase S11 family
C1O30_RS06035	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1O30_RS06040	COG0772	Belongs to the SEDS family
C1O30_RS06045	COG0768	penicillin binding
C1O30_RS06050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1O30_RS06055	COG0799	negative regulation of ribosome biogenesis
C1O30_RS06060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1O30_RS06065	COG1466	dna polymerase III delta subunit
C1O30_RS06070	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
C1O30_RS06075	COG0495	leucyl-tRNA aminoacylation
C1O30_RS06080	COG2888	peptidyl-tyrosine sulfation
C1O30_RS06085	COG1126	abc transporter atp-binding protein
C1O30_RS06090	COG0765	amino acid transport
C1O30_RS06095	COG0765	amino acid transport
C1O30_RS06105	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1O30_RS06110	COG4535	Mg2 and Co2 transporter CorC
C1O30_RS06115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1O30_RS06120	COG1702	phosphate starvation-inducible protein PhoH
C1O30_RS06125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1O30_RS06130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1O30_RS06175	COG0367	asparagine synthase
C1O30_RS06180	COG1940	carbohydrate kinase activity
C1O30_RS06180	COG1846	Transcriptional regulator
C1O30_RS06185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1O30_RS06190	COG0363	glucosamine-6-phosphate deaminase activity
C1O30_RS06195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1O30_RS06195	COG1263	PTS System
C1O30_RS06195	COG2190	(PTS) system
C1O30_RS06200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1O30_RS06205	COG0735	belongs to the Fur family
C1O30_RS06215	COG0716	FMN binding
C1O30_RS06220	COG0840	transmembrane signaling receptor activity
C1O30_RS06230	COG0596	Alpha beta hydrolase
C1O30_RS06240	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C1O30_RS06245	COG0033	Phosphoglucomutase
C1O30_RS06255	COG0745	RESPONSE REGULATOR receiver
C1O30_RS06260	COG2205	protein histidine kinase activity
C1O30_RS06265	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C1O30_RS06270	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C1O30_RS06275	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1O30_RS06290	COG3272	Protein of unknown function (DUF1722)
C1O30_RS06295	COG0415	Belongs to the DNA photolyase family
C1O30_RS06300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1O30_RS06305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C1O30_RS06310	COG1984	allophanate hydrolase subunit 2
C1O30_RS06315	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C1O30_RS06320	COG0372	Belongs to the citrate synthase family
C1O30_RS06325	COG2009	succinate dehydrogenase
C1O30_RS06330	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C1O30_RS06335	COG1053	succinate dehydrogenase
C1O30_RS06340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1O30_RS06345	COG0567	Dehydrogenase, E1 component
C1O30_RS06350	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1O30_RS06355	COG0045	succinate-CoA ligase (ADP-forming) activity
C1O30_RS06360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C1O30_RS06365	COG1271	oxidase subunit
C1O30_RS06370	COG1294	oxidase, subunit
C1O30_RS06375	COG4890	Cyd operon protein YbgT
C1O30_RS06380	COG3790	cyd operon protein YbgE
C1O30_RS06385	COG0824	Thioesterase
C1O30_RS06390	COG0811	peptide transport
C1O30_RS06395	COG0848	biopolymer transport protein
C1O30_RS06400	COG3064	Membrane
C1O30_RS06405	COG0823	Involved in the tonB-independent uptake of proteins
C1O30_RS06410	COG2885	chlorophyll binding
C1O30_RS06415	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C1O30_RS06430	COG1811	Na channel or pump
C1O30_RS06435	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1O30_RS06445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1O30_RS06450	COG0588	phosphoglycerate mutase activity
C1O30_RS06455	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1O30_RS06460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O30_RS06480	COG2017	converts alpha-aldose to the beta-anomer
C1O30_RS06490	COG1085	galactose-1-phosphate uridylyltransferase
C1O30_RS06495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1O30_RS06500	COG1119	ATPase activity
C1O30_RS06505	COG2005	Transcriptional regulator
C1O30_RS06505	COG3585	molybdate ion transport
C1O30_RS06515	COG0725	ABC transporter, periplasmic molybdate-binding protein
C1O30_RS06520	COG4149	molybdate abc transporter
C1O30_RS06525	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C1O30_RS06530	COG0561	phosphatase activity
C1O30_RS06535	COG2706	6-phosphogluconolactonase activity
C1O30_RS06555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1O30_RS06555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1O30_RS06560	COG0489	protein tyrosine kinase activity
C1O30_RS06565	COG0572	uridine kinase
C1O30_RS06570	COG0717	Belongs to the dCTP deaminase family
C1O30_RS06575	COG2982	Protein involved in outer membrane biogenesis
C1O30_RS06580	COG1253	flavin adenine dinucleotide binding
C1O30_RS06630	COG1088	dTDP-glucose 4,6-dehydratase activity
C1O30_RS06635	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C1O30_RS06650	COG1215	transferase activity, transferring glycosyl groups
C1O30_RS06655	COG2244	polysaccharide biosynthetic process
C1O30_RS06665	COG0662	Cupin 2, conserved barrel domain protein
C1O30_RS06665	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C1O30_RS06685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1O30_RS06715	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1O30_RS06730	COG3706	GGDEF domain
C1O30_RS06750	COG2990	Protein conserved in bacteria
C1O30_RS06755	COG0783	Belongs to the Dps family
C1O30_RS06765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1O30_RS06775	COG3501	Rhs element vgr protein
C1O30_RS06840	COG1476	TRANSCRIPTIONal
C1O30_RS06845	COG3209	COG3209 Rhs family protein
C1O30_RS06885	COG1473	amidohydrolase
C1O30_RS06940	COG3829	transcription factor binding
C1O30_RS06980	COG4948	Mandelate Racemase Muconate Lactonizing
C1O30_RS06990	COG4251	negative regulation of phosphorylation
C1O30_RS06990	COG5001	Diguanylate cyclase
C1O30_RS06990	COG3706	GGDEF domain
C1O30_RS06990	COG2203	Gaf domain
C1O30_RS06995	COG0672	)-iron permease
C1O30_RS07000	COG2822	iron ion transport
C1O30_RS07010	COG3813	Protein conserved in bacteria
C1O30_RS07015	COG0477	Major facilitator Superfamily
C1O30_RS07035	COG1902	pentaerythritol trinitrate reductase activity
C1O30_RS07050	COG2814	Major facilitator Superfamily
C1O30_RS07060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1O30_RS07065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O30_RS07070	COG0745	RESPONSE REGULATOR receiver
C1O30_RS07095	COG0488	(ABC) transporter
C1O30_RS07105	COG1556	Lactate utilization protein
C1O30_RS07110	COG1139	Iron-sulfur cluster binding protein
C1O30_RS07115	COG0247	lactate metabolic process
C1O30_RS07120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1O30_RS07130	COG1346	cytolysis
C1O30_RS07150	COG4566	intracellular signal transduction
C1O30_RS07155	COG4191	Histidine kinase
C1O30_RS07160	COG1116	anion transmembrane transporter activity
C1O30_RS07165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1O30_RS07175	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C1O30_RS07180	COG0768	penicillin binding
C1O30_RS07185	COG2226	methyltransferase
C1O30_RS07190	COG0747	negative chemotaxis
C1O30_RS07195	COG0601	transmembrane transport
C1O30_RS07200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O30_RS07205	COG0444	Belongs to the ABC transporter superfamily
C1O30_RS07210	COG1124	(ABC) transporter
C1O30_RS07215	COG1846	Transcriptional regulator
C1O30_RS07220	COG2207	Transcriptional regulator
C1O30_RS07220	COG3708	Transcriptional regulator
C1O30_RS07230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C1O30_RS07235	COG3615	Tellurite resistance protein tehB
C1O30_RS07250	COG4221	oxidoreductase activity
C1O30_RS07250	COG3321	synthase
C1O30_RS07250	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS07250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1O30_RS07260	COG0156	8-amino-7-oxononanoate synthase activity
C1O30_RS07270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1O30_RS07285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1O30_RS07295	COG1819	glycosyl
C1O30_RS07310	COG0534	Mate efflux family protein
C1O30_RS07325	COG0583	DNA-binding transcription factor activity
C1O30_RS07335	COG0583	DNA-binding transcription factor activity
C1O30_RS07340	COG0604	alcohol dehydrogenase
C1O30_RS07375	COG2207	Transcriptional regulator
C1O30_RS07380	COG1403	HNH endonuclease
C1O30_RS07390	COG1522	sequence-specific DNA binding
C1O30_RS07400	COG2070	2-Nitropropane dioxygenase
C1O30_RS07405	COG0583	DNA-binding transcription factor activity
C1O30_RS07415	COG0534	Mate efflux family protein
C1O30_RS07440	COG4221	oxidoreductase activity
C1O30_RS07445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1O30_RS07450	COG4221	oxidoreductase activity
C1O30_RS07460	COG0667	Aldo Keto reductase
C1O30_RS07470	COG4221	oxidoreductase activity
C1O30_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS07480	COG0604	alcohol dehydrogenase
C1O30_RS07485	COG0604	alcohol dehydrogenase
C1O30_RS07515	COG0667	Aldo Keto reductase
C1O30_RS07520	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1O30_RS07585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1O30_RS07610	COG3423	Transcriptional regulator
C1O30_RS07625	COG3501	Rhs element vgr protein
C1O30_RS07670	COG0582	viral genome integration into host DNA
C1O30_RS07680	COG3250	beta-galactosidase activity
C1O30_RS07685	COG1609	Transcriptional regulator
C1O30_RS07695	COG0583	DNA-binding transcription factor activity
C1O30_RS07700	COG1301	dicarboxylic acid transport
C1O30_RS07710	COG3383	formate dehydrogenase (NAD+) activity
C1O30_RS07715	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1O30_RS07720	COG1802	Transcriptional regulator
C1O30_RS07735	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS07755	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C1O30_RS07765	COG3260	NADH ubiquinone oxidoreductase 20
C1O30_RS07770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O30_RS07775	COG3261	NADH dehydrogenase
C1O30_RS07775	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C1O30_RS07780	COG0651	ATP synthesis coupled electron transport
C1O30_RS07785	COG4237	Hydrogenase 4 membrane
C1O30_RS07790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1O30_RS07795	COG0650	Formate hydrogenlyase subunit 4
C1O30_RS07800	COG0651	ATP synthesis coupled electron transport
C1O30_RS07805	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1O30_RS07810	COG0298	carbon dioxide binding
C1O30_RS07825	COG1301	dicarboxylic acid transport
C1O30_RS07835	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1O30_RS07850	COG1012	belongs to the aldehyde dehydrogenase family
C1O30_RS07855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1O30_RS07885	COG2188	Transcriptional regulator
C1O30_RS07890	COG3624	Phosphonate C-P lyase system protein PhnG
C1O30_RS07895	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C1O30_RS07900	COG3626	phosphonate metabolism
C1O30_RS07905	COG3627	carbon phosphorus lyase activity
C1O30_RS07910	COG4107	phosphonate C-P lyase system protein PhnK
C1O30_RS07915	COG4778	phosphonate C-P lyase system protein PhnL
C1O30_RS07920	COG3454	Phosphonate metabolism
C1O30_RS07925	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C1O30_RS07930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1O30_RS07940	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C1O30_RS07950	COG3639	organic phosphonate transmembrane transporter activity
C1O30_RS07955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1O30_RS07965	COG4264	IucA IucC family
C1O30_RS07970	COG0019	diaminopimelate decarboxylase activity
C1O30_RS07975	COG2814	Major facilitator Superfamily
C1O30_RS07980	COG4264	IucA IucC family
C1O30_RS07990	COG4264	IucA IucC family
C1O30_RS08000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1O30_RS08005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1O30_RS08010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1O30_RS08015	COG1120	ATPase activity
C1O30_RS08020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1O30_RS08025	COG1285	pathogenesis
C1O30_RS08035	COG0583	DNA-binding transcription factor activity
C1O30_RS08040	COG2828	Protein conserved in bacteria
C1O30_RS08045	COG2814	Major facilitator Superfamily
C1O30_RS08050	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1O30_RS08060	COG3052	prosthetic group binding
C1O30_RS08085	COG0243	molybdopterin cofactor binding
C1O30_RS08085	COG3383	formate dehydrogenase (NAD+) activity
C1O30_RS08090	COG0437	4 iron, 4 sulfur cluster binding
C1O30_RS08095	COG2864	formate dehydrogenase
C1O30_RS08110	COG2211	Major facilitator Superfamily
C1O30_RS08130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1O30_RS08135	COG2199	diguanylate cyclase activity
C1O30_RS08140	COG3416	Protein conserved in bacteria
C1O30_RS08155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1O30_RS08160	COG2011	ABC-type metal ion transport system permease component
C1O30_RS08165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1O30_RS08185	COG2134	cdp-diacylglycerol pyrophosphatase
C1O30_RS08195	COG4166	transmembrane transport
C1O30_RS08200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1O30_RS08210	COG1957	nucleoside hydrolase
C1O30_RS08215	COG0601	transmembrane transport
C1O30_RS08235	COG0174	glutamine synthetase
C1O30_RS08260	COG0835	chemotaxis
C1O30_RS08260	COG0784	Response regulator, receiver
C1O30_RS08295	COG0679	Auxin Efflux Carrier
C1O30_RS08305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1O30_RS08315	COG0583	DNA-binding transcription factor activity
C1O30_RS08320	COG2271	Major facilitator Superfamily
C1O30_RS08325	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS08330	COG3959	Transketolase, thiamine diphosphate binding domain
C1O30_RS08335	COG3958	Transketolase
C1O30_RS08345	COG0697	spore germination
C1O30_RS08350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1O30_RS08360	COG1984	allophanate hydrolase subunit 2
C1O30_RS08365	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C1O30_RS08385	COG4221	oxidoreductase activity
C1O30_RS08390	COG0765	amino acid transport
C1O30_RS08395	COG0765	amino acid transport
C1O30_RS08410	COG0583	DNA-binding transcription factor activity
C1O30_RS08415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1O30_RS08425	COG2423	ornithine cyclodeaminase activity
C1O30_RS08485	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C1O30_RS08485	COG0456	acetyltransferase
C1O30_RS08660	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1O30_RS08690	COG0582	viral genome integration into host DNA
C1O30_RS08700	COG3228	Belongs to the MtfA family
C1O30_RS08725	COG0463	Glycosyl transferase, family 2
C1O30_RS08725	COG0457	Tetratricopeptide repeat
C1O30_RS08740	COG0303	'Molybdopterin
C1O30_RS08745	COG0281	malic enzyme
C1O30_RS08750	COG0295	cytidine deaminase activity
C1O30_RS08755	COG1346	cytolysis
C1O30_RS08760	COG1380	Effector of murein hydrolase LrgA
C1O30_RS08775	COG2207	Transcriptional regulator
C1O30_RS08795	COG1022	Amp-dependent synthetase and ligase
C1O30_RS08810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1O30_RS08815	COG0156	8-amino-7-oxononanoate synthase activity
C1O30_RS08820	COG2226	methyltransferase
C1O30_RS08830	COG0556	nucleotide-excision repair
C1O30_RS08840	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C1O30_RS08845	COG1271	oxidase subunit
C1O30_RS08850	COG1294	oxidase, subunit
C1O30_RS08860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1O30_RS08865	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1O30_RS08875	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C1O30_RS08900	COG0670	Belongs to the BI1 family
C1O30_RS08910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1O30_RS08915	COG3568	Endonuclease Exonuclease Phosphatase
C1O30_RS08920	COG0842	Transport permease protein
C1O30_RS08925	COG0842	Transport permease protein
C1O30_RS08930	COG1131	(ABC) transporter
C1O30_RS08935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O30_RS08940	COG0513	Belongs to the DEAD box helicase family
C1O30_RS08945	COG0697	spore germination
C1O30_RS08955	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1O30_RS08960	COG0747	negative chemotaxis
C1O30_RS08965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1O30_RS08980	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1O30_RS08985	COG1686	Belongs to the peptidase S11 family
C1O30_RS08995	COG1349	DNA-binding transcription factor activity
C1O30_RS09000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1O30_RS09005	COG1472	Belongs to the glycosyl hydrolase 3 family
C1O30_RS09020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1O30_RS09030	COG0671	phosphoesterase, PA-phosphatase related
C1O30_RS09040	COG1126	abc transporter atp-binding protein
C1O30_RS09045	COG0765	amino acid transport
C1O30_RS09050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1O30_RS09055	COG0783	Belongs to the Dps family
C1O30_RS09060	COG5006	permease, DMT superfamily
C1O30_RS09065	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C1O30_RS09070	COG1846	Transcriptional regulator
C1O30_RS09075	COG2807	transmembrane transport
C1O30_RS09090	COG0511	ligase activity, forming carbon-carbon bonds
C1O30_RS09105	COG1984	allophanate hydrolase subunit 2
C1O30_RS09115	COG0071	Belongs to the small heat shock protein (HSP20) family
C1O30_RS09120	COG3136	membrane protein required for alginate biosynthesis
C1O30_RS09170	COG3157	Type VI secretion system effector, Hcp
C1O30_RS09190	COG3082	Protein of unknown function (DUF1414)
C1O30_RS09195	COG3081	Nucleoid-associated protein
C1O30_RS09200	COG3275	phosphorelay sensor kinase activity
C1O30_RS09205	COG3279	Response regulator of the LytR AlgR family
C1O30_RS09210	COG2223	nitrite transmembrane transporter activity
C1O30_RS09215	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1O30_RS09220	COG1061	Type III restriction enzyme res subunit
C1O30_RS09235	COG2814	Major facilitator Superfamily
C1O30_RS09250	COG4172	Belongs to the ABC transporter superfamily
C1O30_RS09255	COG4239	(ABC) transporter, permease
C1O30_RS09260	COG4174	ABC transporter (Permease)
C1O30_RS09265	COG4166	transmembrane transport
C1O30_RS09270	COG0791	NLP P60 protein
C1O30_RS09275	COG0523	cobalamin synthesis protein
C1O30_RS09280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1O30_RS09300	COG1105	Belongs to the carbohydrate kinase PfkB family
C1O30_RS09305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1O30_RS09305	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C1O30_RS09305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1O30_RS09315	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C1O30_RS09320	COG2855	membrane
C1O30_RS09325	COG0583	DNA-binding transcription factor activity
C1O30_RS09330	COG0833	amino acid
C1O30_RS09340	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1O30_RS09345	COG1129	ABC transporter
C1O30_RS09350	COG0371	Dehydrogenase
C1O30_RS09370	COG0583	DNA-binding transcription factor activity
C1O30_RS09380	COG0840	transmembrane signaling receptor activity
C1O30_RS09410	COG0302	gtp cyclohydrolase
C1O30_RS09415	COG2311	Membrane
C1O30_RS09420	COG2949	membrane
C1O30_RS09425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1O30_RS09430	COG2133	pyrroloquinoline quinone binding
C1O30_RS09435	COG0625	glutathione transferase activity
C1O30_RS09440	COG2267	carboxylic ester hydrolase activity
C1O30_RS09445	COG1686	Belongs to the peptidase S11 family
C1O30_RS09450	COG1349	DNA-binding transcription factor activity
C1O30_RS09455	COG2985	domain, Protein
C1O30_RS09455	COG0569	domain protein
C1O30_RS09480	COG0189	ligase activity
C1O30_RS09490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1O30_RS09495	COG3842	ATPase activity
C1O30_RS09500	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1O30_RS09505	COG1177	transmembrane transport
C1O30_RS09515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1O30_RS09520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1O30_RS09525	COG4160	amino acid transport
C1O30_RS09530	COG4215	(ABC) transporter
C1O30_RS09535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1O30_RS09540	COG1126	abc transporter atp-binding protein
C1O30_RS09545	COG0393	Putative heavy-metal-binding
C1O30_RS09550	COG3023	N-Acetylmuramoyl-L-alanine amidase
C1O30_RS09555	COG0702	epimerase
C1O30_RS09560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1O30_RS09565	COG1151	hydroxylamine reductase activity
C1O30_RS09570	COG3593	DNA synthesis involved in DNA repair
C1O30_RS09575	COG1278	Cold shock
C1O30_RS09580	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1O30_RS09585	COG0542	response to heat
C1O30_RS09590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1O30_RS09595	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1O30_RS09600	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C1O30_RS09605	COG4988	ABC transporter
C1O30_RS09610	COG0492	ferredoxin-NADP+ reductase activity
C1O30_RS09620	COG3107	peptidoglycan biosynthetic process
C1O30_RS09620	COG1674	ftsk spoiiie
C1O30_RS09625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C1O30_RS09630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1O30_RS09635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1O30_RS09640	COG3385	transposase activity
C1O30_RS09645	COG3381	protein complex oligomerization
C1O30_RS09655	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C1O30_RS09665	COG0583	DNA-binding transcription factor activity
C1O30_RS09670	COG2814	Major facilitator Superfamily
C1O30_RS09680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1O30_RS09685	COG1882	Formate acetyltransferase
C1O30_RS09690	COG2116	formate transmembrane transporter activity
C1O30_RS09695	COG1944	ATP diphosphatase activity
C1O30_RS09700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1O30_RS09705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1O30_RS09710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1O30_RS09715	COG0539	negative regulation of cytoplasmic translation
C1O30_RS09720	COG0776	regulation of translation
C1O30_RS09730	COG0140	phosphoribosyl-ATP diphosphatase activity
C1O30_RS09730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1O30_RS09735	COG0107	imidazoleglycerol-phosphate synthase activity
C1O30_RS09740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1O30_RS09745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1O30_RS09750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1O30_RS09750	COG0131	Imidazoleglycerol-phosphate dehydratase
C1O30_RS09755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1O30_RS09760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1O30_RS09765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1O30_RS09770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1O30_RS09775	COG0840	transmembrane signaling receptor activity
C1O30_RS09790	COG3493	citrate carrier protein
C1O30_RS09795	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1O30_RS09805	COG3052	prosthetic group binding
C1O30_RS09820	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
C1O30_RS09820	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C1O30_RS09825	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C1O30_RS09830	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C1O30_RS09840	COG0531	amino acid
C1O30_RS09845	COG2925	Exonuclease
C1O30_RS09850	COG2926	Belongs to the UPF0265 family
C1O30_RS09860	COG0658	competence protein
C1O30_RS09860	COG2333	competence protein COMEC
C1O30_RS09865	COG1132	(ABC) transporter
C1O30_RS09870	COG1663	tetraacyldisaccharide 4'-kinase activity
C1O30_RS09875	COG2835	tetraacyldisaccharide 4'-kinase activity
C1O30_RS09880	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1O30_RS09890	COG3173	Aminoglycoside phosphotransferase
C1O30_RS09895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1O30_RS09900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1O30_RS09905	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
C1O30_RS09910	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C1O30_RS09915	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1O30_RS09925	COG2132	Multicopper oxidase
C1O30_RS09930	COG1733	regulation of RNA biosynthetic process
C1O30_RS09940	COG0494	nUDIX hydrolase
C1O30_RS09950	COG0494	nUDIX hydrolase
C1O30_RS09955	COG1349	DNA-binding transcription factor activity
C1O30_RS09985	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS09990	COG1902	pentaerythritol trinitrate reductase activity
C1O30_RS09995	COG2207	Transcriptional regulator
C1O30_RS10005	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1O30_RS10010	COG3381	protein complex oligomerization
C1O30_RS10020	COG2999	glutathione oxidoreductase activity
C1O30_RS10025	COG0477	Major facilitator Superfamily
C1O30_RS10030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1O30_RS10055	COG0018	arginyl-trna synthetase
C1O30_RS10060	COG3102	Protein conserved in bacteria
C1O30_RS10065	COG3142	Participates in the control of copper homeostasis
C1O30_RS10075	COG0500	methyltransferase
C1O30_RS10080	COG2226	methyltransferase
C1O30_RS10085	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C1O30_RS10090	COG1801	Protein of unknown function DUF72
C1O30_RS10095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1O30_RS10100	COG0494	nUDIX hydrolase
C1O30_RS10105	COG0217	transcriptional regulatory protein
C1O30_RS10115	COG0632	four-way junction helicase activity
C1O30_RS10120	COG2255	four-way junction helicase activity
C1O30_RS10125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1O30_RS10130	COG1121	(ABC) transporter
C1O30_RS10135	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C1O30_RS10140	COG0739	heme binding
C1O30_RS10145	COG1560	Kdo2-lipid A biosynthetic process
C1O30_RS10160	COG0469	pyruvate kinase activity
C1O30_RS10165	COG1737	Transcriptional regulator
C1O30_RS10170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1O30_RS10175	COG0800	Aldolase
C1O30_RS10180	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C1O30_RS10185	COG1770	oligopeptidase
C1O30_RS10200	COG1276	copper resistance
C1O30_RS10205	COG1528	Iron-storage protein
C1O30_RS10220	COG0765	amino acid transport
C1O30_RS10225	COG0765	amino acid transport
C1O30_RS10230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1O30_RS10265	COG2718	Belongs to the UPF0229 family
C1O30_RS10270	COG2766	serine protein kinase
C1O30_RS10275	COG3713	MltA-interacting MipA family protein
C1O30_RS10280	COG0656	L-ascorbic acid biosynthetic process
C1O30_RS10295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1O30_RS10300	COG3139	Protein of unknown function (DUF1315)
C1O30_RS10305	COG1335	isochorismatase
C1O30_RS10310	COG0252	asparaginase activity
C1O30_RS10315	COG0616	signal peptide processing
C1O30_RS10320	COG0778	Nitroreductase
C1O30_RS10325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1O30_RS10340	COG2860	membrane
C1O30_RS10350	COG0788	formyltetrahydrofolate deformylase activity
C1O30_RS10355	COG3012	SEC-C Motif Domain Protein
C1O30_RS10360	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1O30_RS10365	COG0745	RESPONSE REGULATOR receiver
C1O30_RS10370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1O30_RS10380	COG1435	thymidine kinase activity
C1O30_RS10385	COG1012	belongs to the aldehyde dehydrogenase family
C1O30_RS10385	COG1454	alcohol dehydrogenase
C1O30_RS10395	COG2095	MarC family integral membrane protein
C1O30_RS10400	COG4166	transmembrane transport
C1O30_RS10405	COG0601	transmembrane transport
C1O30_RS10410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O30_RS10425	COG3099	Belongs to the UPF0263 family
C1O30_RS10430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1O30_RS10440	COG2350	Protein conserved in bacteria
C1O30_RS10455	COG2917	probably involved in intracellular septation
C1O30_RS10465	COG0727	PFAM Uncharacterised protein family (UPF0153)
C1O30_RS10470	COG3047	cAMP biosynthetic process
C1O30_RS10475	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1O30_RS10480	COG0159	tryptophan synthase activity
C1O30_RS10485	COG0133	tryptophan synthase activity
C1O30_RS10490	COG0134	indole-3-glycerol-phosphate synthase activity
C1O30_RS10490	COG0135	phosphoribosylanthranilate isomerase activity
C1O30_RS10495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1O30_RS10500	COG0512	Glutamine amidotransferase of anthranilate synthase
C1O30_RS10510	COG0613	PHP domain protein
C1O30_RS10515	COG0009	L-threonylcarbamoyladenylate synthase
C1O30_RS10520	COG1187	pseudouridine synthase activity
C1O30_RS10525	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C1O30_RS10530	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS10535	COG0616	signal peptide processing
C1O30_RS10555	COG0583	DNA-binding transcription factor activity
C1O30_RS10560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1O30_RS10570	COG4659	FMN binding
C1O30_RS10575	COG4658	electron transport chain
C1O30_RS10580	COG4656	Part of a membrane complex involved in electron transport
C1O30_RS10585	COG2878	Part of a membrane complex involved in electron transport
C1O30_RS10590	COG4657	Part of a membrane complex involved in electron transport
C1O30_RS10605	COG2160	L-arabinose isomerase activity
C1O30_RS10610	COG1069	ribulokinase activity
C1O30_RS10615	COG1879	ABC-type sugar transport system periplasmic component
C1O30_RS10620	COG1129	ABC transporter
C1O30_RS10625	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1O30_RS10635	COG0673	inositol 2-dehydrogenase activity
C1O30_RS10640	COG0385	Bile acid
C1O30_RS10650	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1O30_RS10655	COG5339	Protein conserved in bacteria
C1O30_RS10660	COG1482	cell wall glycoprotein biosynthetic process
C1O30_RS10665	COG0114	fumarate hydratase activity
C1O30_RS10675	COG2814	Major facilitator Superfamily
C1O30_RS10680	COG0583	DNA-binding transcription factor activity
C1O30_RS10685	COG1940	carbohydrate kinase activity
C1O30_RS10690	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1O30_RS10705	COG4221	oxidoreductase activity
C1O30_RS10710	COG2226	methyltransferase
C1O30_RS10715	COG1215	transferase activity, transferring glycosyl groups
C1O30_RS10760	COG2315	Protein conserved in bacteria
C1O30_RS10770	COG1275	C4-dicarboxylate transporter malic acid transport protein
C1O30_RS10775	COG4305	rare lipoprotein A
C1O30_RS10780	COG3158	transport of potassium into the cell
C1O30_RS10830	COG0702	epimerase
C1O30_RS10860	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C1O30_RS10865	COG0483	inositol monophosphate 1-phosphatase activity
C1O30_RS10870	COG0584	glycerophosphoryl diester phosphodiesterase
C1O30_RS10880	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1O30_RS10885	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1O30_RS10890	COG3842	ATPase activity
C1O30_RS10905	COG3479	Phenolic acid decarboxylase
C1O30_RS10910	COG3385	transposase activity
C1O30_RS10915	COG0840	transmembrane signaling receptor activity
C1O30_RS10930	COG0840	transmembrane signaling receptor activity
C1O30_RS10940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1O30_RS10950	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1O30_RS10955	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C1O30_RS10965	COG3385	transposase activity
C1O30_RS10970	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1O30_RS10980	COG2890	protein-(glutamine-N5) methyltransferase activity
C1O30_RS10985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1O30_RS10990	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1O30_RS10995	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C1O30_RS11000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1O30_RS11005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1O30_RS11015	COG0193	aminoacyl-tRNA hydrolase activity
C1O30_RS11020	COG0012	GTP binding
C1O30_RS11055	COG0513	Belongs to the DEAD box helicase family
C1O30_RS11080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1O30_RS11085	COG1074	ATP-dependent DNA helicase activity
C1O30_RS11090	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C1O30_RS11110	COG5297	Belongs to the glycosyl hydrolase family 6
C1O30_RS11145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1O30_RS11150	COG2719	SpoVR family
C1O30_RS11155	COG2186	Transcriptional regulator
C1O30_RS11160	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1O30_RS11180	COG2983	Belongs to the UPF0260 family
C1O30_RS11185	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1O30_RS11195	COG0850	regulation of cytokinetic process
C1O30_RS11200	COG2894	cell division
C1O30_RS11205	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C1O30_RS11210	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1O30_RS11215	COG0318	PFAM AMP-dependent synthetase and ligase
C1O30_RS11220	COG3065	identical protein binding
C1O30_RS11230	COG1199	ATP-dependent helicase activity
C1O30_RS11235	COG0251	oxidation-reduction process
C1O30_RS11245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1O30_RS11250	COG0494	nUDIX hydrolase
C1O30_RS11255	COG1760	l-serine dehydratase
C1O30_RS11260	COG1253	flavin adenine dinucleotide binding
C1O30_RS11265	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1O30_RS11265	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1O30_RS11270	COG3715	PTS system
C1O30_RS11275	COG3716	PTS system mannose fructose sorbose family IID component
C1O30_RS11280	COG4811	Protein of unknown function (DUF986)
C1O30_RS11285	COG1971	Probably functions as a manganese efflux pump
C1O30_RS11290	COG2226	methyltransferase
C1O30_RS11305	COG3001	Fructosamine kinase
C1O30_RS11315	COG1917	Cupin 2, conserved barrel domain protein
C1O30_RS11320	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C1O30_RS11325	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS11335	COG1175	transmembrane transport
C1O30_RS11340	COG0395	ABC-type sugar transport system, permease component
C1O30_RS11345	COG3842	ATPase activity
C1O30_RS11350	COG1653	transport
C1O30_RS11355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1O30_RS11360	COG2755	lipolytic protein G-D-S-L family
C1O30_RS11360	COG0657	acetylesterase activity
C1O30_RS11365	COG1988	membrane-bound metal-dependent
C1O30_RS11370	COG1823	symporter activity
C1O30_RS11375	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1O30_RS11380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C1O30_RS11395	COG0776	regulation of translation
C1O30_RS11400	COG0072	phenylalanine-tRNA ligase activity
C1O30_RS11400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1O30_RS11405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1O30_RS11415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1O30_RS11420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1O30_RS11425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1O30_RS11440	COG0823	Involved in the tonB-independent uptake of proteins
C1O30_RS11445	COG0501	Belongs to the peptidase M48B family
C1O30_RS11450	COG3300	MHYT domain
C1O30_RS11450	COG5001	Diguanylate cyclase
C1O30_RS11455	COG0538	isocitrate dehydrogenase activity
C1O30_RS11460	COG1187	pseudouridine synthase activity
C1O30_RS11470	COG0482	sulfurtransferase activity
C1O30_RS11475	COG2915	High frequency lysogenization protein hflD homolog
C1O30_RS11480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1O30_RS11495	COG2850	peptidyl-arginine hydroxylation
C1O30_RS11500	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1O30_RS11550	COG3210	domain, Protein
C1O30_RS11550	COG3210	domain, Protein
C1O30_RS11555	COG2831	hemolysin activation secretion protein
C1O30_RS11610	COG2951	lytic endotransglycosylase activity
C1O30_RS11690	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1O30_RS11700	COG4794	Type iii secretion
C1O30_RS11710	COG4792	protein secretion
C1O30_RS11720	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C1O30_RS11725	COG0840	transmembrane signaling receptor activity
C1O30_RS11750	COG0626	cystathionine gamma-synthase activity
C1O30_RS11755	COG0765	amino acid transport
C1O30_RS11760	COG0765	amino acid transport
C1O30_RS11765	COG1126	abc transporter atp-binding protein
C1O30_RS11775	COG0561	phosphatase activity
C1O30_RS11780	COG2223	nitrite transmembrane transporter activity
C1O30_RS11785	COG0483	inositol monophosphate 1-phosphatase activity
C1O30_RS11790	COG1349	DNA-binding transcription factor activity
C1O30_RS11805	COG0583	DNA-binding transcription factor activity
C1O30_RS11810	COG0395	ABC-type sugar transport system, permease component
C1O30_RS11815	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1O30_RS11825	COG1012	belongs to the aldehyde dehydrogenase family
C1O30_RS11830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1O30_RS11840	COG3842	ATPase activity
C1O30_RS11870	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C1O30_RS11880	COG2271	Major facilitator Superfamily
C1O30_RS11885	COG1609	Transcriptional regulator
C1O30_RS11890	COG0386	Belongs to the glutathione peroxidase family
C1O30_RS11895	COG1733	regulation of RNA biosynthetic process
C1O30_RS11900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1O30_RS11915	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C1O30_RS11920	COG1454	alcohol dehydrogenase
C1O30_RS11925	COG2181	nitrate reductase activity
C1O30_RS11930	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C1O30_RS11935	COG1140	nitrate reductase beta subunit
C1O30_RS11940	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C1O30_RS11945	COG0583	DNA-binding transcription factor activity
C1O30_RS11955	COG2223	nitrite transmembrane transporter activity
C1O30_RS11960	COG3850	Histidine kinase
C1O30_RS11965	COG2197	response regulator
C1O30_RS11980	COG0300	oxidoreductase activity
C1O30_RS11995	COG1408	metallophosphoesterase
C1O30_RS12000	COG0583	DNA-binding transcription factor activity
C1O30_RS12005	COG0793	Belongs to the peptidase S41A family
C1O30_RS12010	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C1O30_RS12015	COG1956	GAF domain-containing protein
C1O30_RS12020	COG2995	paraquat-inducible protein a
C1O30_RS12025	COG3008	intermembrane lipid transfer
C1O30_RS12030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1O30_RS12030	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C1O30_RS12040	COG0840	transmembrane signaling receptor activity
C1O30_RS12060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1O30_RS12120	COG2840	Smr protein MutS2
C1O30_RS12130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1O30_RS12190	COG0402	S-adenosylhomocysteine deaminase activity
C1O30_RS12200	COG0840	transmembrane signaling receptor activity
C1O30_RS12220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1O30_RS12225	COG0038	chloride channel
C1O30_RS12235	COG1124	(ABC) transporter
C1O30_RS12240	COG0444	Belongs to the ABC transporter superfamily
C1O30_RS12245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O30_RS12250	COG0601	transmembrane transport
C1O30_RS12255	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C1O30_RS12260	COG0387	Pfam Sodium calcium exchanger
C1O30_RS12265	COG0659	secondary active sulfate transmembrane transporter activity
C1O30_RS12275	COG0745	RESPONSE REGULATOR receiver
C1O30_RS12280	COG2205	protein histidine kinase activity
C1O30_RS12290	COG3591	Belongs to the peptidase S1B family
C1O30_RS12295	COG1620	l-lactate permease
C1O30_RS12300	COG0247	lactate metabolic process
C1O30_RS12305	COG1139	Iron-sulfur cluster binding protein
C1O30_RS12310	COG1556	Lactate utilization protein
C1O30_RS12315	COG1643	Atp-dependent helicase
C1O30_RS12320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1O30_RS12330	COG2911	Protein conserved in bacteria
C1O30_RS12335	COG0840	transmembrane signaling receptor activity
C1O30_RS12340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1O30_RS12350	COG0840	transmembrane signaling receptor activity
C1O30_RS12370	COG0037	tRNA processing
C1O30_RS12380	COG0598	Magnesium transport protein CorA
C1O30_RS12385	COG4166	transmembrane transport
C1O30_RS12390	COG2866	Carboxypeptidase
C1O30_RS12395	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C1O30_RS12400	COG0477	Major facilitator Superfamily
C1O30_RS12415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1O30_RS12440	COG2814	Major facilitator Superfamily
C1O30_RS12445	COG3768	UPF0283 membrane protein
C1O30_RS12450	COG3106	COG3106 Predicted ATPase
C1O30_RS12455	COG1983	PspC domain protein
C1O30_RS12465	COG1842	Phage shock protein A
C1O30_RS12470	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C1O30_RS12480	COG4166	transmembrane transport
C1O30_RS12495	COG4172	Belongs to the ABC transporter superfamily
C1O30_RS12510	COG0583	DNA-binding transcription factor activity
C1O30_RS12515	COG0243	molybdopterin cofactor binding
C1O30_RS12530	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C1O30_RS12535	COG4989	oxidoreductase activity
C1O30_RS12540	COG1966	Carbon starvation protein
C1O30_RS12560	COG0023	Translation Initiation Factor
C1O30_RS12565	COG0284	orotidine-5'-phosphate decarboxylase activity
C1O30_RS12570	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C1O30_RS12575	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C1O30_RS12585	COG0671	phosphoesterase, PA-phosphatase related
C1O30_RS12600	COG0625	glutathione transferase activity
C1O30_RS12605	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C1O30_RS12615	COG0259	pyridoxamine-phosphate oxidase activity
C1O30_RS12620	COG3895	Periplasmic Protein
C1O30_RS12625	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1O30_RS12640	COG3313	Fe-S protein
C1O30_RS12645	COG0346	lactoylglutathione lyase activity
C1O30_RS12650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1O30_RS12655	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C1O30_RS12660	COG0791	NLP P60 protein
C1O30_RS12670	COG1609	Transcriptional regulator
C1O30_RS12675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1O30_RS12680	COG0307	riboflavin synthase, alpha
C1O30_RS12685	COG0534	Mate efflux family protein
C1O30_RS12700	COG2382	esterase
C1O30_RS12725	COG4238	major outer membrane lipoprotein
C1O30_RS12730	COG1376	ErfK ybiS ycfS ynhG family protein
C1O30_RS12730	COG1388	LysM domain
C1O30_RS12740	COG2050	protein possibly involved in aromatic compounds catabolism
C1O30_RS12745	COG0247	lactate metabolic process
C1O30_RS12745	COG0277	FAD linked oxidase domain protein
C1O30_RS12750	COG0628	permease
C1O30_RS12760	COG0574	Belongs to the PEP-utilizing enzyme family
C1O30_RS12760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1O30_RS12765	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C1O30_RS12770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1O30_RS12775	COG3130	regulation of translation
C1O30_RS12780	COG3009	Protein conserved in bacteria
C1O30_RS12785	COG3008	intermembrane lipid transfer
C1O30_RS12785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1O30_RS12790	COG2995	paraquat-inducible protein a
C1O30_RS12795	COG0488	(ABC) transporter
C1O30_RS12800	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1O30_RS12800	COG0116	Belongs to the methyltransferase superfamily
C1O30_RS12805	COG3217	Mosc domain protein beta barrel domain protein
C1O30_RS12805	COG0633	Ferredoxin
C1O30_RS12815	COG0167	dihydroorotate dehydrogenase activity
C1O30_RS12820	COG0431	NADPH-dependent FMN reductase
C1O30_RS12825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1O30_RS12830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1O30_RS12835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1O30_RS12840	COG1116	anion transmembrane transporter activity
C1O30_RS12845	COG0308	aminopeptidase N
C1O30_RS12850	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C1O30_RS12855	COG0017	Asparaginyl-tRNA synthetase
C1O30_RS12875	COG1448	Aminotransferase
C1O30_RS12880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1O30_RS12885	COG3108	Peptidase M15
C1O30_RS12890	COG2989	Protein conserved in bacteria
C1O30_RS12895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C1O30_RS12905	COG0095	Lipoate-protein ligase
C1O30_RS12910	COG0791	NLP P60 protein
C1O30_RS12915	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C1O30_RS12920	COG0386	Belongs to the glutathione peroxidase family
C1O30_RS12925	COG4139	cobalamin transport
C1O30_RS12940	COG1940	carbohydrate kinase activity
C1O30_RS12945	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1O30_RS12950	COG1136	(ABC) transporter
C1O30_RS12955	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1O30_RS12960	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1O30_RS12965	COG2200	EAL domain
C1O30_RS12970	COG0443	Heat shock 70 kDa protein
C1O30_RS12985	COG2271	Major facilitator Superfamily
C1O30_RS12990	COG1609	Transcriptional regulator
C1O30_RS12995	COG3134	Outer membrane lipoprotein
C1O30_RS13000	COG1252	NADH dehydrogenase
C1O30_RS13005	COG3150	esterase
C1O30_RS13010	COG1472	Belongs to the glycosyl hydrolase 3 family
C1O30_RS13020	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C1O30_RS13030	COG0537	adenosine 5'-monophosphoramidase activity
C1O30_RS13035	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C1O30_RS13040	COG1263	PTS System
C1O30_RS13040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1O30_RS13045	COG0084	hydrolase, TatD family'
C1O30_RS13050	COG0470	DNA polymerase III
C1O30_RS13055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1O30_RS13060	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1O30_RS13065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1O30_RS13070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1O30_RS13075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1O30_RS13090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1O30_RS13095	COG0416	fatty acid biosynthetic process
C1O30_RS13100	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1O30_RS13105	COG1399	metal-binding, possibly nucleic acid-binding protein
C1O30_RS13110	COG0424	maF-like protein
C1O30_RS13115	COG0564	pseudouridine synthase activity
C1O30_RS13125	COG1530	ribonuclease E activity
C1O30_RS13135	COG0418	dihydroorotase activity
C1O30_RS13150	COG3038	cytochrome b561
C1O30_RS13160	COG1054	Belongs to the UPF0176 family
C1O30_RS13165	COG1902	pentaerythritol trinitrate reductase activity
C1O30_RS13170	COG1560	Kdo2-lipid A biosynthetic process
C1O30_RS13175	COG2814	Major facilitator Superfamily
C1O30_RS13180	COG2943	transferase activity, transferring hexosyl groups
C1O30_RS13185	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C1O30_RS13200	COG0840	transmembrane signaling receptor activity
C1O30_RS13220	COG1067	ATP-dependent peptidase activity
C1O30_RS13225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1O30_RS13245	COG1702	phosphate starvation-inducible protein PhoH
C1O30_RS13260	COG1191	sigma factor activity
C1O30_RS13280	COG0318	PFAM AMP-dependent synthetase and ligase
C1O30_RS13285	COG3958	Transketolase
C1O30_RS13290	COG3959	Transketolase, thiamine diphosphate binding domain
C1O30_RS13295	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS13300	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS13320	COG0500	methyltransferase
C1O30_RS13330	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C1O30_RS13345	COG1677	Flagellar hook-basal body complex protein FliE
C1O30_RS13355	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1O30_RS13365	COG1157	protein secretion by the type III secretion system
C1O30_RS13415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1O30_RS13420	COG1256	bacterial-type flagellum assembly
C1O30_RS13430	COG1706	bacterial-type flagellum-dependent cell motility
C1O30_RS13435	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1O30_RS13445	COG4787	bacterial-type flagellum-dependent cell motility
C1O30_RS13450	COG1749	Flagellar hook protein flgE
C1O30_RS13455	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C1O30_RS13460	COG1558	bacterial-type flagellum-dependent cell motility
C1O30_RS13465	COG1815	bacterial-type flagellum-dependent cell motility
C1O30_RS13475	COG2747	anti-sigma28 factor FlgM
C1O30_RS13490	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1O30_RS13495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1O30_RS13500	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C1O30_RS13505	COG0745	RESPONSE REGULATOR receiver
C1O30_RS13510	COG2201	protein-glutamate methylesterase activity
C1O30_RS13515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1O30_RS13520	COG0840	transmembrane signaling receptor activity
C1O30_RS13525	COG0835	chemotaxis
C1O30_RS13530	COG2198	Histidine kinase
C1O30_RS13530	COG0643	Histidine kinase
C1O30_RS13555	COG0840	transmembrane signaling receptor activity
C1O30_RS13570	COG0534	Mate efflux family protein
C1O30_RS13580	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C1O30_RS13585	COG4733	cellulase activity
C1O30_RS13620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1O30_RS13625	COG0322	excinuclease ABC activity
C1O30_RS13630	COG2197	response regulator
C1O30_RS13645	COG1113	amino acid transport
C1O30_RS13660	COG1819	glycosyl
C1O30_RS13670	COG0840	transmembrane signaling receptor activity
C1O30_RS13675	COG1619	proteins homologs of microcin C7 resistance protein MccF
C1O30_RS13680	COG0583	DNA-binding transcription factor activity
C1O30_RS13685	COG0436	Aminotransferase
C1O30_RS13715	COG1648	precorrin-2 dehydrogenase activity
C1O30_RS13715	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1O30_RS13720	COG0243	molybdopterin cofactor binding
C1O30_RS13725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1O30_RS13725	COG2146	nitrite reductase [NAD(P)H] activity
C1O30_RS13730	COG1116	anion transmembrane transporter activity
C1O30_RS13740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1O30_RS13745	COG3707	response regulator
C1O30_RS13755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1O30_RS13760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O30_RS13770	COG2814	Major facilitator Superfamily
C1O30_RS13775	COG0657	acetylesterase activity
C1O30_RS13780	COG3058	Necessary for formate dehydrogenase activity
C1O30_RS13785	COG2271	Major facilitator Superfamily
C1O30_RS13795	COG2864	formate dehydrogenase
C1O30_RS13800	COG0437	4 iron, 4 sulfur cluster binding
C1O30_RS13805	COG0243	molybdopterin cofactor binding
C1O30_RS13805	COG3383	formate dehydrogenase (NAD+) activity
C1O30_RS13810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1O30_RS13815	COG0519	Catalyzes the synthesis of GMP from XMP
C1O30_RS13815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1O30_RS13825	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C1O30_RS13835	COG0309	Hydrogenase expression formation protein (HypE)
C1O30_RS13840	COG0409	Hydrogenase expression formation protein
C1O30_RS13845	COG0298	carbon dioxide binding
C1O30_RS13850	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1O30_RS13860	COG1773	rubredoxin
C1O30_RS13865	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C1O30_RS13870	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C1O30_RS13875	COG5557	Pfam Polysulphide reductase, NrfD
C1O30_RS13880	COG0437	4 iron, 4 sulfur cluster binding
C1O30_RS13885	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C1O30_RS13890	COG0488	(ABC) transporter
C1O30_RS13895	COG0384	phenazine biosynthesis protein PhzF
C1O30_RS13900	COG1007	ATP synthesis coupled electron transport
C1O30_RS13905	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O30_RS13910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1O30_RS13915	COG0713	ATP synthesis coupled electron transport
C1O30_RS13920	COG0839	Belongs to the complex I subunit 6 family
C1O30_RS13925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O30_RS13930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1O30_RS13940	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1O30_RS13950	COG0649	NAD binding
C1O30_RS13950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O30_RS13960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1O30_RS13965	COG0583	DNA-binding transcription factor activity
C1O30_RS13970	COG0436	Aminotransferase
C1O30_RS13975	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C1O30_RS13980	COG0471	metal ion transport
C1O30_RS13980	COG0490	domain, Protein
C1O30_RS13985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1O30_RS13990	COG3013	Belongs to the UPF0304 family
C1O30_RS13995	COG3092	negative regulation of chromosome organization
C1O30_RS14000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1O30_RS14005	COG0857	belongs to the CobB CobQ family
C1O30_RS14005	COG0280	phosphate acetyltransferase
C1O30_RS14010	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1O30_RS14015	COG0622	Phosphoesterase
C1O30_RS14020	COG0625	glutathione transferase activity
C1O30_RS14025	COG1090	epimerase
C1O30_RS14030	COG4598	ABC transporter
C1O30_RS14040	COG4215	(ABC) transporter
C1O30_RS14045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1O30_RS14050	COG0163	prenyltransferase activity
C1O30_RS14055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1O30_RS14060	COG1286	toxin biosynthetic process
C1O30_RS14065	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C1O30_RS14070	COG0285	dihydrofolate synthase activity
C1O30_RS14075	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1O30_RS14080	COG0586	Pfam SNARE associated Golgi protein
C1O30_RS14085	COG0101	tRNA pseudouridine synthase activity
C1O30_RS14090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1O30_RS14095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1O30_RS14100	COG0642	Histidine kinase
C1O30_RS14130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1O30_RS14135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C1O30_RS14135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1O30_RS14140	COG0840	transmembrane signaling receptor activity
C1O30_RS14180	COG3101	peptidyl-lysine hydroxylation
C1O30_RS14185	COG0730	response to heat
C1O30_RS14190	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C1O30_RS14195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1O30_RS14200	COG2890	protein-(glutamine-N5) methyltransferase activity
C1O30_RS14205	COG2840	Smr protein MutS2
C1O30_RS14210	COG2062	phosphohistidine phosphatase, SixA
C1O30_RS14215	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1O30_RS14215	COG1024	Enoyl-CoA hydratase
C1O30_RS14220	COG0183	Belongs to the thiolase family
C1O30_RS14225	COG3691	Protein conserved in bacteria
C1O30_RS14230	COG2067	long-chain fatty acid transport protein
C1O30_RS14250	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C1O30_RS14260	COG4592	Periplasmic binding protein
C1O30_RS14270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1O30_RS14275	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1O30_RS14280	COG1120	ATPase activity
C1O30_RS14300	COG2382	esterase
C1O30_RS14305	COG4774	siderophore transport
C1O30_RS14310	COG1169	isochorismate synthase
C1O30_RS14315	COG1021	2,3-dihydroxybenzoate-AMP ligase
C1O30_RS14320	COG1535	isochorismatase
C1O30_RS14320	COG3433	isochorismatase activity
C1O30_RS14325	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS14330	COG2050	protein possibly involved in aromatic compounds catabolism
C1O30_RS14335	COG3385	transposase activity
C1O30_RS14345	COG1902	pentaerythritol trinitrate reductase activity
C1O30_RS14410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1O30_RS14425	COG3266	domain, Protein
C1O30_RS14435	COG0436	Aminotransferase
C1O30_RS14440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1O30_RS14445	COG3264	Mechanosensitive ion channel
C1O30_RS14445	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1O30_RS14490	COG1473	amidohydrolase
C1O30_RS14495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1O30_RS14505	COG4608	Belongs to the ABC transporter superfamily
C1O30_RS14510	COG0444	Belongs to the ABC transporter superfamily
C1O30_RS14515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O30_RS14520	COG0601	transmembrane transport
C1O30_RS14535	COG2267	carboxylic ester hydrolase activity
C1O30_RS14540	COG2199	diguanylate cyclase activity
C1O30_RS14540	COG2203	Gaf domain
C1O30_RS14560	COG2850	peptidyl-arginine hydroxylation
C1O30_RS14580	COG5297	Belongs to the glycosyl hydrolase family 6
C1O30_RS14595	COG1904	glucuronate isomerase
C1O30_RS14605	COG0246	Mannitol dehydrogenase
C1O30_RS14610	COG1802	Transcriptional regulator
C1O30_RS14615	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C1O30_RS14620	COG2986	histidine ammonia-lyase
C1O30_RS14625	COG1116	anion transmembrane transporter activity
C1O30_RS14630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1O30_RS14650	COG2188	Transcriptional regulator
C1O30_RS14660	COG3290	protein histidine kinase activity
C1O30_RS14665	COG4565	transcriptional regulatory protein
C1O30_RS14670	COG2986	histidine ammonia-lyase
C1O30_RS14700	COG0402	S-adenosylhomocysteine deaminase activity
C1O30_RS14705	COG1228	amidohydrolase
C1O30_RS14715	COG0840	transmembrane signaling receptor activity
C1O30_RS14720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1O30_RS14725	COG2501	S4 domain
C1O30_RS14730	COG0215	cysteine-tRNA ligase activity
C1O30_RS14740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1O30_RS14745	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1O30_RS14750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1O30_RS14755	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1O30_RS14760	COG0814	amino acid
C1O30_RS14765	COG1760	l-serine dehydratase
C1O30_RS14775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1O30_RS14780	COG0581	inorganic phosphate transmembrane transporter activity
C1O30_RS14785	COG0573	inorganic phosphate transmembrane transporter activity
C1O30_RS14790	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1O30_RS14805	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1O30_RS14810	COG0589	response to stress
C1O30_RS14830	COG0670	Belongs to the BI1 family
C1O30_RS14835	COG1733	regulation of RNA biosynthetic process
C1O30_RS14840	COG1028	Short-chain dehydrogenase reductase Sdr
C1O30_RS14845	COG2920	part of a sulfur-relay system
C1O30_RS14850	COG1254	Belongs to the acylphosphatase family
C1O30_RS14855	COG3785	DNA binding
C1O30_RS14860	COG1832	CoA-binding protein
C1O30_RS14865	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C1O30_RS14870	COG1803	Methylglyoxal synthase
C1O30_RS14875	COG0210	DNA helicase
C1O30_RS14880	COG3304	Inner membrane component domain
C1O30_RS14885	COG1289	transmembrane transporter activity
C1O30_RS14890	COG3070	regulator of competence-specific genes
C1O30_RS14895	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
C1O30_RS14900	COG2885	chlorophyll binding
C1O30_RS14900	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C1O30_RS14905	COG0667	Aldo Keto reductase
C1O30_RS14910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1O30_RS14915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1O30_RS14920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1O30_RS14925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1O30_RS14930	COG0477	Major facilitator Superfamily
C1O30_RS14935	COG2205	protein histidine kinase activity
C1O30_RS14940	COG0745	RESPONSE REGULATOR receiver
C1O30_RS14945	COG0435	Glutathione S-transferase
C1O30_RS14950	COG0826	peptidase U32
C1O30_RS14955	COG3223	Belongs to the PsiE family
C1O30_RS14960	COG3622	Belongs to the hyi family
C1O30_RS14965	COG2211	Major facilitator Superfamily
C1O30_RS14975	COG0673	inositol 2-dehydrogenase activity
C1O30_RS14990	COG0351	phosphomethylpyrimidine kinase
C1O30_RS14995	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C1O30_RS15000	COG3328	transposase activity
C1O30_RS15055	COG1942	4-Oxalocrotonate Tautomerase
C1O30_RS15075	COG2814	Major facilitator Superfamily
C1O30_RS15080	COG0789	Transcriptional regulator
C1O30_RS15090	COG0300	oxidoreductase activity
C1O30_RS15105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1O30_RS15120	COG3272	Protein of unknown function (DUF1722)
C1O30_RS15130	COG3240	lipase activity
C1O30_RS15130	COG4625	pathogenesis
C1O30_RS15155	COG1309	transcriptional regulator
C1O30_RS15160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1O30_RS15160	COG0519	Catalyzes the synthesis of GMP from XMP
C1O30_RS15165	COG0516	GMP reductase activity
C1O30_RS15165	COG0517	IMP dehydrogenase activity
C1O30_RS15170	COG1570	exodeoxyribonuclease VII activity
C1O30_RS15185	COG1645	bacterial-type flagellum-dependent swarming motility
C1O30_RS15190	COG1160	GTP binding
C1O30_RS15195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1O30_RS15200	COG2976	Protein conserved in bacteria
C1O30_RS15205	COG0124	histidyl-tRNA synthetase
C1O30_RS15210	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1O30_RS15215	COG1426	Protein conserved in bacteria
C1O30_RS15225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1O30_RS15230	COG0105	UTP biosynthetic process
C1O30_RS15235	COG2897	thiosulfate sulfurtransferase activity
C1O30_RS15245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1O30_RS15250	COG2975	iron-sulfur cluster assembly
C1O30_RS15255	COG0633	Ferredoxin
C1O30_RS15260	COG0443	Heat shock 70 kDa protein
C1O30_RS15265	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1O30_RS15270	COG0316	Belongs to the HesB IscA family
C1O30_RS15275	COG0822	iron-sulfur transferase activity
C1O30_RS15285	COG1959	2 iron, 2 sulfur cluster binding
C1O30_RS15290	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C1O30_RS15295	COG0483	inositol monophosphate 1-phosphatase activity
C1O30_RS15305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1O30_RS15310	COG1120	ATPase activity
C1O30_RS15320	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C1O30_RS15325	COG3683	transport system, periplasmic component
C1O30_RS15330	COG2814	Major facilitator Superfamily
C1O30_RS15335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1O30_RS15340	COG1017	nitric oxide dioxygenase activity
C1O30_RS15340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1O30_RS15345	COG3866	Pectate lyase
C1O30_RS15365	COG4677	pectinesterase activity
C1O30_RS15370	COG0347	Belongs to the P(II) protein family
C1O30_RS15375	COG2204	response regulator
C1O30_RS15385	COG2205	protein histidine kinase activity
C1O30_RS15390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1O30_RS15390	COG0047	phosphoribosylformylglycinamidine synthase activity
C1O30_RS15395	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1O30_RS15405	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C1O30_RS15415	COG2274	protein secretion by the type I secretion system
C1O30_RS15430	COG2200	EAL domain
C1O30_RS15435	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1O30_RS15440	COG0736	holo-[acyl-carrier-protein] synthase activity
C1O30_RS15445	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1O30_RS15450	COG1381	Involved in DNA repair and RecF pathway recombination
C1O30_RS15455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C1O30_RS15460	COG0571	ribonuclease III activity
C1O30_RS15470	COG0481	GTPase activity
C1O30_RS15475	COG3086	response to oxidative stress
C1O30_RS15480	COG3026	antisigma factor binding
C1O30_RS15495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1O30_RS15500	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C1O30_RS15505	COG0513	Belongs to the DEAD box helicase family
C1O30_RS15510	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
C1O30_RS15515	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1O30_RS15530	COG2873	o-acetylhomoserine
C1O30_RS15535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1O30_RS15570	COG3385	transposase activity
C1O30_RS15575	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1O30_RS15580	COG4208	sulfate ABC transporter
C1O30_RS15585	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C1O30_RS15590	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C1O30_RS15595	COG3835	regulator
C1O30_RS15600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1O30_RS15605	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1O30_RS15610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1O30_RS15615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1O30_RS15620	COG0316	Belongs to the HesB IscA family
C1O30_RS15635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1O30_RS15640	COG1643	Atp-dependent helicase
C1O30_RS15645	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C1O30_RS15650	COG1489	DNA binding
C1O30_RS15655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1O30_RS15660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1O30_RS15665	COG0617	tRNA 3'-terminal CCA addition
C1O30_RS15670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1O30_RS15675	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1O30_RS15680	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1O30_RS15685	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C1O30_RS15690	COG0842	Transport permease protein
C1O30_RS15695	COG1131	(ABC) transporter
C1O30_RS15700	COG0288	reversible hydration of carbon dioxide
C1O30_RS15705	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C1O30_RS15720	COG3842	ATPase activity
C1O30_RS15735	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C1O30_RS15740	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C1O30_RS15750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1O30_RS15760	COG2226	methyltransferase
C1O30_RS15765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1O30_RS15770	COG0741	lytic transglycosylase activity
C1O30_RS15770	COG1388	LysM domain
C1O30_RS15775	COG3021	interspecies interaction between organisms
C1O30_RS15810	COG0542	response to heat
C1O30_RS15815	COG1496	oxidoreductase activity
C1O30_RS15820	COG0564	pseudouridine synthase activity
C1O30_RS15825	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1O30_RS15830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1O30_RS15835	COG0077	Prephenate dehydratase
C1O30_RS15835	COG1605	Chorismate mutase
C1O30_RS15840	COG0287	Prephenate dehydrogenase
C1O30_RS15840	COG1605	Chorismate mutase
C1O30_RS15845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1O30_RS15865	COG0336	Belongs to the RNA methyltransferase TrmD family
C1O30_RS15870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1O30_RS15875	COG0228	four-way junction DNA binding
C1O30_RS15880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1O30_RS15885	COG4137	Cytochrome C assembly protein
C1O30_RS15895	COG2918	glutathione biosynthetic process
C1O30_RS15900	COG1238	metal cluster binding
C1O30_RS15905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1O30_RS15930	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C1O30_RS15935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1O30_RS15940	COG2137	regulation of response to DNA damage stimulus
C1O30_RS15945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1O30_RS15950	COG1546	Belongs to the CinA family
C1O30_RS15965	COG3038	cytochrome b561
C1O30_RS15970	COG1280	lysine exporter protein (LysE YggA)
C1O30_RS15995	COG1879	ABC-type sugar transport system periplasmic component
C1O30_RS16000	COG1129	ABC transporter
C1O30_RS16005	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1O30_RS16010	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1O30_RS16015	COG0688	phosphatidylethanolamine metabolic process
C1O30_RS16025	COG2207	Transcriptional regulator
C1O30_RS16030	COG0523	cobalamin synthesis protein
C1O30_RS16035	COG2879	small protein
C1O30_RS16040	COG1966	Carbon starvation protein
C1O30_RS16050	COG3275	phosphorelay sensor kinase activity
C1O30_RS16060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1O30_RS16070	COG0601	transmembrane transport
C1O30_RS16075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O30_RS16085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1O30_RS16095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1O30_RS16115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1O30_RS16120	COG1696	Membrane protein involved in D-alanine export
C1O30_RS16150	COG2161	toxin-antitoxin pair type II binding
C1O30_RS16185	COG2003	Belongs to the UPF0758 family
C1O30_RS16195	COG3596	GTP binding
C1O30_RS16260	COG4983	Phage plasmid primase, P4 family domain protein
C1O30_RS16290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1O30_RS16295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1O30_RS16305	COG1073	alpha beta
C1O30_RS16310	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C1O30_RS16320	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1O30_RS16325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1O30_RS16330	COG3034	peptidoglycan biosynthetic process
C1O30_RS16335	COG0121	glutamine amidotransferase
C1O30_RS16340	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1O30_RS16345	COG1960	acyl-CoA dehydrogenase activity
C1O30_RS16350	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C1O30_RS16355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C1O30_RS16365	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C1O30_RS16370	COG0235	Class ii aldolase
C1O30_RS16375	COG0436	Aminotransferase
C1O30_RS16395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1O30_RS16405	COG0765	amino acid transport
C1O30_RS16410	COG0765	amino acid transport
C1O30_RS16460	COG1953	Uracil, thiamine, allantoin
C1O30_RS16475	COG4175	Glycine betaine
C1O30_RS16480	COG4176	ABC-type proline glycine betaine transport system permease component
C1O30_RS16485	COG2113	Glycine betaine
C1O30_RS16490	COG2814	Major facilitator Superfamily
C1O30_RS16495	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C1O30_RS16505	COG1846	Transcriptional regulator
C1O30_RS16510	COG1566	PFAM secretion protein HlyD family protein
C1O30_RS16515	COG2814	Major facilitator Superfamily
C1O30_RS16520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1O30_RS16525	COG3118	belongs to the thioredoxin family
C1O30_RS16530	COG3148	PFAM DTW domain containing protein
C1O30_RS16535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1O30_RS16535	COG1042	CoA-binding domain protein
C1O30_RS16535	COG0045	succinate-CoA ligase (ADP-forming) activity
C1O30_RS16540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1O30_RS16545	COG0477	Major facilitator Superfamily
C1O30_RS16590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1O30_RS16595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1O30_RS16605	COG1464	Belongs to the NlpA lipoprotein family
C1O30_RS16615	COG1720	tRNA m6t6A37 methyltransferase activity
C1O30_RS16620	COG0442	prolyl-tRNA aminoacylation
C1O30_RS16635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1O30_RS16640	COG0585	pseudouridine synthase activity
C1O30_RS16645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1O30_RS16650	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1O30_RS16655	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C1O30_RS16665	COG0529	Catalyzes the synthesis of activated sulfate
C1O30_RS16670	COG2895	sulfate adenylyltransferase (ATP) activity
C1O30_RS16680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1O30_RS16680	COG1648	precorrin-2 dehydrogenase activity
C1O30_RS16685	COG0175	sulfate reduction
C1O30_RS16690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1O30_RS16695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1O30_RS16705	COG1653	transport
C1O30_RS16715	COG0720	synthase
C1O30_RS16720	COG0602	queuosine metabolic process
C1O30_RS16725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1O30_RS16730	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C1O30_RS16745	COG0504	CTP synthase activity
C1O30_RS16750	COG3956	TIGRFAM MazG family protein
C1O30_RS16755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1O30_RS16760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1O30_RS16770	COG1929	Belongs to the glycerate kinase type-1 family
C1O30_RS16775	COG2084	Dehydrogenase
C1O30_RS16785	COG4948	Mandelate Racemase Muconate Lactonizing
C1O30_RS16790	COG4948	Mandelate Racemase Muconate Lactonizing
C1O30_RS16795	COG2271	Major facilitator Superfamily
C1O30_RS16800	COG2721	sulfolactate sulfo-lyase activity
C1O30_RS16805	COG0840	transmembrane signaling receptor activity
C1O30_RS16820	COG3530	Putative quorum-sensing-regulated virulence factor
C1O30_RS16825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1O30_RS16830	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1O30_RS16830	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1O30_RS16835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1O30_RS16840	COG3025	triphosphatase activity
C1O30_RS16845	COG4991	sh3 domain protein
C1O30_RS16850	COG0617	tRNA 3'-terminal CCA addition
C1O30_RS16855	COG1968	undecaprenyl-diphosphatase activity
C1O30_RS16860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1O30_RS16865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C1O30_RS16875	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1O30_RS16885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1O30_RS16895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1O30_RS16900	COG2105	PFAM AIG2 family protein
C1O30_RS16905	COG2911	Protein conserved in bacteria
C1O30_RS16915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1O30_RS16920	COG1253	flavin adenine dinucleotide binding
C1O30_RS16930	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1O30_RS16935	COG0737	Belongs to the 5'-nucleotidase family
C1O30_RS16940	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C1O30_RS16950	COG0545	Peptidyl-prolyl cis-trans isomerase
C1O30_RS16955	COG3061	Opacity-associated protein A
C1O30_RS16970	COG1609	Transcriptional regulator
C1O30_RS16975	COG0840	transmembrane signaling receptor activity
C1O30_RS16980	COG2271	Major facilitator Superfamily
C1O30_RS16985	COG0359	binds to the 23S rRNA
C1O30_RS16990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1O30_RS16995	COG2965	DNA replication, synthesis of RNA primer
C1O30_RS17005	COG1073	alpha beta
C1O30_RS17010	COG0840	transmembrane signaling receptor activity
C1O30_RS17025	COG0840	transmembrane signaling receptor activity
C1O30_RS17030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1O30_RS17035	COG0557	exoribonuclease II activity
C1O30_RS17040	COG1959	2 iron, 2 sulfur cluster binding
C1O30_RS17045	COG0840	transmembrane signaling receptor activity
C1O30_RS17055	COG0402	S-adenosylhomocysteine deaminase activity
C1O30_RS17065	COG2805	Type II/IV secretion system protein
C1O30_RS17070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1O30_RS17075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1O30_RS17080	COG0762	integral membrane protein
C1O30_RS17085	COG1872	DUF167
C1O30_RS17090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1O30_RS17095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1O30_RS17100	COG3706	GGDEF domain
C1O30_RS17115	COG2153	protein acetylation
C1O30_RS17120	COG0477	Major facilitator Superfamily
C1O30_RS17125	COG0318	PFAM AMP-dependent synthetase and ligase
C1O30_RS17125	COG0204	Acyl-transferase
C1O30_RS17135	COG1609	Transcriptional regulator
C1O30_RS17145	COG2186	Transcriptional regulator
C1O30_RS17150	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1O30_RS17155	COG2723	6-phospho-beta-galactosidase activity
C1O30_RS17160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1O30_RS17165	COG1447	Phosphotransferase system cellobiose-specific component IIA
C1O30_RS17170	COG1609	Transcriptional regulator
C1O30_RS17180	COG0583	DNA-binding transcription factor activity
C1O30_RS17185	COG3842	ATPase activity
C1O30_RS17195	COG4149	molybdate abc transporter
C1O30_RS17200	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1O30_RS17220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1O30_RS17240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1O30_RS17260	COG1522	sequence-specific DNA binding
C1O30_RS17270	COG1448	Aminotransferase
C1O30_RS17305	COG1203	CRISPR-associated helicase, Cas3
C1O30_RS17310	COG1518	maintenance of DNA repeat elements
C1O30_RS17315	COG0840	transmembrane signaling receptor activity
C1O30_RS17325	COG0432	Pfam Uncharacterised protein family UPF0047
C1O30_RS17335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1O30_RS17380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C1O30_RS17470	COG1609	Transcriptional regulator
C1O30_RS17475	COG0395	ABC-type sugar transport system, permease component
C1O30_RS17480	COG1175	transmembrane transport
C1O30_RS17485	COG3842	ATPase activity
C1O30_RS17490	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C1O30_RS17510	COG2971	BadF BadG BcrA BcrD
C1O30_RS17520	COG0725	ABC transporter, periplasmic molybdate-binding protein
C1O30_RS17525	COG1121	(ABC) transporter
C1O30_RS17530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1O30_RS17535	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1O30_RS17540	COG2368	4-hydroxyphenylacetate
C1O30_RS17560	COG0167	dihydroorotate dehydrogenase activity
C1O30_RS17580	COG1349	DNA-binding transcription factor activity
C1O30_RS17585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1O30_RS17590	COG3395	kinase activity
C1O30_RS17595	COG1454	alcohol dehydrogenase
C1O30_RS17600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1O30_RS17615	COG2731	YhcH YjgK YiaL family protein
C1O30_RS17625	COG0840	transmembrane signaling receptor activity
C1O30_RS17630	COG3112	Uncharacterised protein family (UPF0231)
C1O30_RS17640	COG2079	MmgE PrpD family protein
C1O30_RS17650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1O30_RS17655	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1O30_RS17660	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1O30_RS17675	COG3725	Membrane protein required for beta-lactamase induction
C1O30_RS17680	COG3023	N-Acetylmuramoyl-L-alanine amidase
C1O30_RS17695	COG4969	Belongs to the N-Me-Phe pilin family
C1O30_RS17700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1O30_RS17705	COG1459	type II secretion system
C1O30_RS17715	COG0237	dephospho-CoA kinase activity
C1O30_RS17720	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C1O30_RS17730	COG0494	nUDIX hydrolase
C1O30_RS17735	COG0653	protein targeting
C1O30_RS17750	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1O30_RS17755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1O30_RS17760	COG0849	cell division
C1O30_RS17765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1O30_RS17770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1O30_RS17775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1O30_RS17780	COG0772	Belongs to the SEDS family
C1O30_RS17785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1O30_RS17790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1O30_RS17795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1O30_RS17800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1O30_RS17805	COG0768	penicillin binding
C1O30_RS17810	COG3116	cell division
C1O30_RS17815	COG0275	rRNA processing
C1O30_RS17820	COG2001	Belongs to the MraZ family
C1O30_RS17840	COG0028	Belongs to the TPP enzyme family
C1O30_RS17845	COG1022	Amp-dependent synthetase and ligase
C1O30_RS17850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1O30_RS17855	COG0473	3-isopropylmalate dehydrogenase activity
C1O30_RS17860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1O30_RS17865	COG0066	3-isopropylmalate dehydratase activity
C1O30_RS17880	COG3033	Beta-eliminating lyase
C1O30_RS17890	COG4533	DNA binding
C1O30_RS17895	COG4143	(ABC) transporter
C1O30_RS17900	COG1178	ABC-type Fe3 transport system permease component
C1O30_RS17905	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1O30_RS17915	COG0028	Belongs to the TPP enzyme family
C1O30_RS17920	COG0440	acetolactate synthase activity
C1O30_RS17925	COG0586	Pfam SNARE associated Golgi protein
C1O30_RS17945	COG3157	Type VI secretion system effector, Hcp
C1O30_RS17950	COG0417	DNA replication proofreading
C1O30_RS17955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1O30_RS17960	COG0564	pseudouridine synthase activity
C1O30_RS17965	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1O30_RS17970	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1O30_RS17975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1O30_RS17980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1O30_RS17985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1O30_RS17990	COG2967	ApaG domain
C1O30_RS17995	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1O30_RS18005	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C1O30_RS18015	COG2966	Psort location CytoplasmicMembrane, score
C1O30_RS18020	COG1280	lysine exporter protein (LysE YggA)
C1O30_RS18025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1O30_RS18035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1O30_RS18045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1O30_RS18050	COG1047	Peptidyl-prolyl cis-trans
C1O30_RS18055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1O30_RS18060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1O30_RS18065	COG0196	riboflavin kinase activity
C1O30_RS18075	COG0268	Binds directly to 16S ribosomal RNA
C1O30_RS18080	COG0583	DNA-binding transcription factor activity
C1O30_RS18085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1O30_RS18090	COG0484	heat shock protein binding
C1O30_RS18100	COG1584	GPR1 FUN34 yaaH family protein
C1O30_RS18110	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1O30_RS18115	COG3706	GGDEF domain
C1O30_RS18120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1O30_RS18125	COG3022	response to hydroperoxide
C1O30_RS18135	COG0083	homoserine kinase activity
C1O30_RS18145	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C1O30_RS18150	COG0745	RESPONSE REGULATOR receiver
C1O30_RS18155	COG3045	CreA protein
C1O30_RS18160	COG2207	Transcriptional regulator
C1O30_RS18160	COG3708	Transcriptional regulator
C1O30_RS18165	COG0406	alpha-ribazole phosphatase activity
C1O30_RS18170	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
C1O30_RS18175	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
C1O30_RS18185	COG0488	(ABC) transporter
C1O30_RS18190	COG0840	transmembrane signaling receptor activity
C1O30_RS18200	COG0604	alcohol dehydrogenase
C1O30_RS18205	COG3385	transposase activity
C1O30_RS18210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1O30_RS18215	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C1O30_RS18220	COG0583	DNA-binding transcription factor activity
C1O30_RS18225	COG2968	Membrane
C1O30_RS18230	COG1414	Transcriptional regulator
C1O30_RS18235	COG0668	transmembrane transport
C1O30_RS18245	COG0126	phosphoglycerate kinase activity
C1O30_RS18250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1O30_RS18255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1O30_RS18260	COG0738	Major facilitator superfamily
C1O30_RS18265	COG1166	arginine decarboxylase activity
C1O30_RS18275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1O30_RS18280	COG3091	SprT-like family
C1O30_RS18285	COG2356	endonuclease I
C1O30_RS18290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1O30_RS18295	COG0189	ligase activity
C1O30_RS18300	COG1678	Uncharacterized ACR, COG1678
C1O30_RS18305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1O30_RS18310	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C1O30_RS18315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1O30_RS18320	COG3385	transposase activity
C1O30_RS18325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1O30_RS18330	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C1O30_RS18335	COG0330	HflC and HflK could
C1O30_RS18340	COG0330	HflC and HflK could
C1O30_RS18345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1O30_RS18350	COG1923	regulation of RNA biosynthetic process
C1O30_RS18355	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1O30_RS18360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1O30_RS18370	COG0802	atpase or kinase
C1O30_RS18375	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1O30_RS18375	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1O30_RS18385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1O30_RS18395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1O30_RS18410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1O30_RS18415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1O30_RS18435	COG0765	amino acid transport
C1O30_RS18440	COG1126	abc transporter atp-binding protein
C1O30_RS18445	COG1764	response to oxidative stress
C1O30_RS18450	COG1846	Transcriptional regulator
C1O30_RS18455	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C1O30_RS18460	COG1473	amidohydrolase
C1O30_RS18470	COG0583	DNA-binding transcription factor activity
C1O30_RS18480	COG0840	transmembrane signaling receptor activity
C1O30_RS18525	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C1O30_RS18530	COG1162	GTPase activity
C1O30_RS18535	COG0688	phosphatidylethanolamine metabolic process
C1O30_RS18540	COG3264	Mechanosensitive ion channel
C1O30_RS18540	COG1511	domain protein
C1O30_RS18550	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C1O30_RS18555	COG1053	succinate dehydrogenase
C1O30_RS18560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1O30_RS18565	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C1O30_RS18570	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C1O30_RS18575	COG3040	lipid binding
C1O30_RS18585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1O30_RS18590	COG1509	lysine 2,3-aminomutase activity
C1O30_RS18600	COG0166	Belongs to the GPI family
C1O30_RS18605	COG0527	aspartate kinase activity
C1O30_RS18610	COG1283	sodium-dependent phosphate transmembrane transporter activity
C1O30_RS18615	COG0471	metal ion transport
C1O30_RS18620	COG1410	methionine synthase
C1O30_RS18620	COG0646	methionine synthase
C1O30_RS18630	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C1O30_RS18640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1O30_RS18645	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C1O30_RS18685	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C1O30_RS18695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1O30_RS18700	COG0009	L-threonylcarbamoyladenylate synthase
C1O30_RS18705	COG0551	DNA topoisomerase type I activity
C1O30_RS18710	COG2922	Belongs to the Smg family
C1O30_RS18715	COG0758	DNA mediated transformation
C1O30_RS18720	COG0242	peptide deformylase activity
C1O30_RS18725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1O30_RS18730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1O30_RS18730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1O30_RS18740	COG1970	mechanosensitive ion channel activity
C1O30_RS18745	COG3036	rescue of stalled ribosome
C1O30_RS18755	COG0203	ribosomal protein L17
C1O30_RS18765	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1O30_RS18775	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1O30_RS18780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1O30_RS18785	COG0201	protein transport
C1O30_RS18790	COG0200	Binds to the 23S rRNA
C1O30_RS18795	COG1841	ribosomal large subunit assembly
C1O30_RS18800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1O30_RS18810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1O30_RS18820	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1O30_RS18850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1O30_RS18865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1O30_RS18870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1O30_RS18875	COG0089	rRNA binding
C1O30_RS18880	COG0088	Forms part of the polypeptide exit tunnel
C1O30_RS18885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1O30_RS18890	COG0051	transcription antitermination factor activity, RNA binding
C1O30_RS18905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1O30_RS18915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1O30_RS18925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1O30_RS18930	COG2168	tRNA wobble position uridine thiolation
C1O30_RS18935	COG2923	Belongs to the DsrF TusC family
C1O30_RS18940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C1O30_RS18945	COG2964	Protein conserved in bacteria
C1O30_RS18955	COG0745	RESPONSE REGULATOR receiver
C1O30_RS18960	COG0642	Histidine kinase
C1O30_RS18990	COG0545	Peptidyl-prolyl cis-trans isomerase
C1O30_RS18995	COG2900	Belongs to the SlyX family
C1O30_RS19015	COG2140	Oxalate decarboxylase
C1O30_RS19020	COG1047	Peptidyl-prolyl cis-trans
C1O30_RS19025	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C1O30_RS19030	COG0475	glutathione-regulated potassium exporter activity
C1O30_RS19030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1O30_RS19035	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1O30_RS19040	COG0488	(ABC) transporter
C1O30_RS19050	COG0429	hydrolase of the alpha beta-hydrolase fold
C1O30_RS19060	COG3954	Phosphoribulokinase
C1O30_RS19065	COG1765	OsmC-like protein
C1O30_RS19075	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C1O30_RS19085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1O30_RS19100	COG3623	hexulose-6-phosphate isomerase
C1O30_RS19175	COG1404	Belongs to the peptidase S8 family
C1O30_RS19180	COG3179	chitinase
C1O30_RS19200	COG0076	glutamate decarboxylase activity
C1O30_RS19220	COG3706	GGDEF domain
C1O30_RS19225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1O30_RS19230	COG4948	Mandelate Racemase Muconate Lactonizing
C1O30_RS19240	COG0546	phosphoglycolate phosphatase activity
C1O30_RS19245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1O30_RS19260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1O30_RS19265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1O30_RS19270	COG4796	Type ii and iii secretion system protein
C1O30_RS19295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1O30_RS19300	COG0494	nUDIX hydrolase
C1O30_RS19310	COG1011	Hydrolase
C1O30_RS19315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C1O30_RS19320	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C1O30_RS19325	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C1O30_RS19340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1O30_RS19355	COG2183	response to ionizing radiation
C1O30_RS19370	COG2267	carboxylic ester hydrolase activity
C1O30_RS19380	COG0316	Belongs to the HesB IscA family
C1O30_RS19380	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C1O30_RS19385	COG1640	4-alpha-glucanotransferase
C1O30_RS19390	COG0058	SHG alpha-glucan phosphorylase activity
C1O30_RS19395	COG1349	DNA-binding transcription factor activity
C1O30_RS19400	COG0705	Rhomboid family
C1O30_RS19405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1O30_RS19415	COG2731	YhcH YjgK YiaL family protein
C1O30_RS19420	COG2271	Major facilitator Superfamily
C1O30_RS19425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1O30_RS19430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1O30_RS19435	COG0058	SHG alpha-glucan phosphorylase activity
C1O30_RS19440	COG0297	glycogen (starch) synthase activity
C1O30_RS19445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1O30_RS19460	COG3275	phosphorelay sensor kinase activity
C1O30_RS19465	COG1278	Cold shock
C1O30_RS19475	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1O30_RS19480	COG2095	MarC family integral membrane protein
C1O30_RS19485	COG2610	gluconate transmembrane transporter activity
C1O30_RS19490	COG3265	gluconokinase activity
C1O30_RS19495	COG1609	Transcriptional regulator
C1O30_RS19505	COG1741	Belongs to the pirin family
C1O30_RS19510	COG0247	lactate metabolic process
C1O30_RS19515	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C1O30_RS19520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1O30_RS19525	COG2271	Major facilitator Superfamily
C1O30_RS19530	COG0584	glycerophosphoryl diester phosphodiesterase
C1O30_RS19535	COG0561	phosphatase activity
C1O30_RS19540	COG2267	carboxylic ester hydrolase activity
C1O30_RS19545	COG1280	lysine exporter protein (LysE YggA)
C1O30_RS19550	COG1280	lysine exporter protein (LysE YggA)
C1O30_RS19555	COG0514	ATP-dependent DNA helicase (RecQ)
C1O30_RS19565	COG2050	protein possibly involved in aromatic compounds catabolism
C1O30_RS19575	COG3180	Ammonia monooxygenase
C1O30_RS19580	COG0598	Magnesium transport protein CorA
C1O30_RS19585	COG0210	DNA helicase
C1O30_RS19590	COG1011	Hydrolase
C1O30_RS19605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1O30_RS19625	COG0181	hydroxymethylbilane synthase activity
C1O30_RS19630	COG1587	Uroporphyrinogen-III synthase
C1O30_RS19635	COG2959	enzyme of heme biosynthesis
C1O30_RS19640	COG3071	HemY protein
C1O30_RS19645	COG1473	amidohydrolase
C1O30_RS19650	COG1126	abc transporter atp-binding protein
C1O30_RS19655	COG0765	amino acid transport
C1O30_RS19660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1O30_RS19665	COG0456	acetyltransferase
C1O30_RS19670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1O30_RS19700	COG1113	amino acid transport
C1O30_RS19705	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C1O30_RS19715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1O30_RS19720	COG2244	polysaccharide biosynthetic process
C1O30_RS19725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1O30_RS19735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C1O30_RS19740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C1O30_RS19745	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C1O30_RS19755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1O30_RS19765	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1O30_RS19770	COG3118	belongs to the thioredoxin family
C1O30_RS19775	COG0513	Belongs to the DEAD box helicase family
C1O30_RS19780	COG0248	Ppx GppA phosphatase
C1O30_RS19795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1O30_RS19805	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C1O30_RS19805	COG0506	proline dehydrogenase activity
C1O30_RS19805	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C1O30_RS19820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1O30_RS19840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1O30_RS19845	COG0129	dihydroxy-acid dehydratase activity
C1O30_RS19850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1O30_RS19855	COG3978	acetolactate synthase activity
C1O30_RS19870	COG2814	Major facilitator Superfamily
C1O30_RS19885	COG0583	DNA-binding transcription factor activity
C1O30_RS19925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C1O30_RS19935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1O30_RS19950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1O30_RS19960	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1O30_RS19960	COG0678	peroxiredoxin activity
C1O30_RS19970	COG0460	homoserine dehydrogenase
C1O30_RS19970	COG0527	aspartate kinase activity
C1O30_RS19975	COG0626	cystathionine gamma-synthase activity
C1O30_RS19980	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
C1O30_RS19990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1O30_RS19995	COG1609	Transcriptional regulator
C1O30_RS20000	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1O30_RS20005	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C1O30_RS20010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C1O30_RS20015	COG1575	Belongs to the MenA family. Type 1 subfamily
C1O30_RS20020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1O30_RS20025	COG3074	FtsZ-dependent cytokinesis
C1O30_RS20040	COG1494	fructose-1,6-bisphosphatase
C1O30_RS20050	COG3152	Membrane
C1O30_RS20060	COG0149	triose-phosphate isomerase activity
C1O30_RS20135	COG3423	Transcriptional regulator
C1O30_RS20150	COG3210	domain, Protein
C1O30_RS20160	COG2831	hemolysin activation secretion protein
C1O30_RS20165	COG2957	Belongs to the agmatine deiminase family
C1O30_RS20170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1O30_RS20175	COG0205	6-phosphofructokinase activity
C1O30_RS20185	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C1O30_RS20245	COG3678	ATP-independent chaperone mediated protein folding
C1O30_RS20250	COG0745	RESPONSE REGULATOR receiver
C1O30_RS20255	COG2205	protein histidine kinase activity
C1O30_RS20280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C1O30_RS20290	COG0679	Auxin Efflux Carrier
C1O30_RS20295	COG0584	glycerophosphoryl diester phosphodiesterase
C1O30_RS20300	COG3842	ATPase activity
C1O30_RS20305	COG0395	ABC-type sugar transport system, permease component
C1O30_RS20310	COG1175	transmembrane transport
C1O30_RS20315	COG1653	transport
C1O30_RS20320	COG1349	DNA-binding transcription factor activity
C1O30_RS20325	COG2084	Dehydrogenase
C1O30_RS20330	COG3395	kinase activity
C1O30_RS20335	COG0235	Class ii aldolase
C1O30_RS20340	COG3622	Belongs to the hyi family
C1O30_RS20350	COG2610	gluconate transmembrane transporter activity
C1O30_RS20355	COG0840	transmembrane signaling receptor activity
C1O30_RS20360	COG0840	transmembrane signaling receptor activity
C1O30_RS20365	COG0840	transmembrane signaling receptor activity
C1O30_RS20380	COG0840	transmembrane signaling receptor activity
C1O30_RS20400	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C1O30_RS20405	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1O30_RS20410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1O30_RS20420	COG4177	L-phenylalanine transmembrane transporter activity
C1O30_RS20425	COG0559	Belongs to the binding-protein-dependent transport system permease family
C1O30_RS20430	COG0683	leucine binding
C1O30_RS20435	COG0456	acetyltransferase
C1O30_RS20445	COG2177	Part of the ABC transporter FtsEX involved in
C1O30_RS20450	COG2884	Cell division ATP-binding protein ftsE
C1O30_RS20455	COG0552	protein localization to endoplasmic reticulum
C1O30_RS20460	COG0742	ribosomal rna small subunit methyltransferase
C1O30_RS20465	COG3776	membrane
C1O30_RS20475	COG3714	YhhN family
C1O30_RS20480	COG0425	Belongs to the sulfur carrier protein TusA family
C1O30_RS20485	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1O30_RS20495	COG0477	Major facilitator Superfamily
C1O30_RS20500	COG1295	ribonuclease BN
C1O30_RS20505	COG1942	4-Oxalocrotonate Tautomerase
C1O30_RS20510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1O30_RS20520	COG1045	serine acetyltransferase
C1O30_RS20525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1O30_RS20530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1O30_RS20540	COG1301	dicarboxylic acid transport
C1O30_RS20545	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C1O30_RS20555	COG0457	Tetratricopeptide repeat
C1O30_RS20565	COG1215	transferase activity, transferring glycosyl groups
C1O30_RS20570	COG0489	protein tyrosine kinase activity
C1O30_RS20585	COG2378	regulation of single-species biofilm formation
C1O30_RS20595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1O30_RS20605	COG4608	Belongs to the ABC transporter superfamily
C1O30_RS20610	COG0444	Belongs to the ABC transporter superfamily
C1O30_RS20615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1O30_RS20620	COG0601	transmembrane transport
C1O30_RS20625	COG0747	negative chemotaxis
C1O30_RS20630	COG3493	citrate carrier protein
C1O30_RS20635	COG4565	transcriptional regulatory protein
C1O30_RS20640	COG3290	protein histidine kinase activity
C1O30_RS20645	COG0471	metal ion transport
C1O30_RS20655	COG0071	Belongs to the small heat shock protein (HSP20) family
C1O30_RS20660	COG0071	Belongs to the small heat shock protein (HSP20) family
C1O30_RS20665	COG5645	(Lipo)protein
C1O30_RS20675	COG0477	Major facilitator Superfamily
C1O30_RS20685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1O30_RS20695	COG1069	ribulokinase activity
C1O30_RS20700	COG0823	Involved in the tonB-independent uptake of proteins
C1O30_RS20720	COG0561	phosphatase activity
C1O30_RS20725	COG0840	transmembrane signaling receptor activity
C1O30_RS20730	COG0589	response to stress
C1O30_RS20740	COG0306	phosphate transporter
C1O30_RS20745	COG2081	HI0933 family
C1O30_RS20760	COG3842	ATPase activity
C1O30_RS20765	COG0395	ABC-type sugar transport system, permease component
C1O30_RS20805	COG3048	D-serine ammonia-lyase activity
C1O30_RS20820	COG2814	Major facilitator Superfamily
C1O30_RS20825	COG0583	DNA-binding transcription factor activity
C1O30_RS20840	COG4221	oxidoreductase activity
C1O30_RS20855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1O30_RS20860	COG0194	GDP metabolic process
C1O30_RS20870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1O30_RS20875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1O30_RS20880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1O30_RS20885	COG2233	PERMEase
C1O30_RS20890	COG2982	Protein involved in outer membrane biogenesis
C1O30_RS20895	COG0456	acetyltransferase
C1O30_RS20900	COG1490	D-aminoacyl-tRNA deacylase activity
C1O30_RS20905	COG1011	Hydrolase
C1O30_RS20910	COG1217	gtp-binding protein TYPA
C1O30_RS20920	COG3852	Histidine kinase
C1O30_RS20935	COG3078	GTPase activator activity
C1O30_RS20940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1O30_RS20945	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1O30_RS20945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1O30_RS20950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1O30_RS20955	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C1O30_RS20960	COG3084	Protein conserved in bacteria
C1O30_RS20970	COG1763	Mo-molybdopterin cofactor biosynthetic process
C1O30_RS20995	COG1609	Transcriptional regulator
C1O30_RS21000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1O30_RS21005	COG1879	ABC-type sugar transport system periplasmic component
C1O30_RS21010	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1O30_RS21015	COG1129	ABC transporter
C1O30_RS21020	COG1869	D-ribose catabolic process
C1O30_RS21025	COG3158	transport of potassium into the cell
C1O30_RS21030	COG0714	Associated with various cellular activities
C1O30_RS21035	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C1O30_RS21040	COG1522	sequence-specific DNA binding
C1O30_RS21045	COG0716	FMN binding
C1O30_RS21050	COG0445	tRNA wobble uridine modification
C1O30_RS21055	COG0357	Ribosomal RNA small subunit methyltransferase G
C1O30_RS21060	COG3312	ion transport
C1O30_RS21065	COG0356	it plays a direct role in the translocation of protons across the membrane
C1O30_RS21075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1O30_RS21080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1O30_RS21085	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1O30_RS21090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1O30_RS21095	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1O30_RS21100	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1O30_RS21110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1O30_RS21115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1O30_RS21145	COG3706	GGDEF domain
C1O30_RS21150	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C1O30_RS21155	COG0573	inorganic phosphate transmembrane transporter activity
C1O30_RS21160	COG0581	inorganic phosphate transmembrane transporter activity
C1O30_RS21165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1O30_RS21175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1O30_RS21185	COG0765	amino acid transport
C1O30_RS21190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1O30_RS21195	COG2252	PERMEase
C1O30_RS21200	COG2091	lysine biosynthetic process via aminoadipic acid
C1O30_RS21205	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1O30_RS21210	COG0493	'glutamate synthase
C1O30_RS21210	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1O30_RS21245	COG0726	polysaccharide deacetylase
C1O30_RS21250	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1O30_RS21255	COG2076	Multidrug Resistance protein
C1O30_RS21260	COG2076	Multidrug Resistance protein
C1O30_RS21270	COG2910	NAD(P)H-binding
C1O30_RS21275	COG1733	regulation of RNA biosynthetic process
C1O30_RS21285	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1O30_RS21315	COG3645	SOS response
C1O30_RS21320	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C1O30_RS21325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1O30_RS21330	COG0706	membrane insertase activity
C1O30_RS21335	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1O30_RS21340	COG0594	ribonuclease P activity