locus-tag	class	description
A6035_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6035_RS00010	COG0592	DNA-directed DNA polymerase activity
A6035_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6035_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
A6035_RS00025	COG0187	DNA topoisomerase II activity
A6035_RS00040	COG0438	transferase activity, transferring glycosyl groups
A6035_RS00050	COG2188	Transcriptional regulator
A6035_RS00055	COG1914	H( )-stimulated, divalent metal cation uptake system
A6035_RS00060	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6035_RS00075	COG1984	allophanate hydrolase subunit 2
A6035_RS00080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6035_RS00100	COG2814	Major facilitator Superfamily
A6035_RS00115	COG3976	FMN-binding domain protein
A6035_RS00115	COG1053	succinate dehydrogenase
A6035_RS00115	COG0431	NADPH-dependent FMN reductase
A6035_RS00145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6035_RS00150	COG1132	(ABC) transporter
A6035_RS00155	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS00160	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A6035_RS00175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6035_RS00180	COG0705	Rhomboid family
A6035_RS00180	COG0457	Tetratricopeptide repeat
A6035_RS00200	COG2815	serine threonine protein kinase
A6035_RS00200	COG0515	serine threonine protein kinase
A6035_RS00205	COG0515	serine threonine protein kinase
A6035_RS00210	COG0768	penicillin binding
A6035_RS00230	COG1716	ATPase activity
A6035_RS00235	COG0463	Glycosyl transferase, family 2
A6035_RS00280	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6035_RS00285	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6035_RS00305	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6035_RS00310	COG2218	PFAM glutamate synthase alpha subunit domain protein
A6035_RS00315	COG0069	glutamate synthase activity
A6035_RS00325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6035_RS00330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6035_RS00335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6035_RS00340	COG3387	PFAM Glycoside hydrolase 15-related
A6035_RS00345	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS00355	COG1960	acyl-CoA dehydrogenase activity
A6035_RS00375	COG0596	Alpha beta hydrolase
A6035_RS00430	COG2353	YceI-like domain
A6035_RS00445	COG2072	flavoprotein involved in K transport
A6035_RS00485	COG2169	Transcriptional regulator
A6035_RS00485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6035_RS00490	COG1280	lysine exporter protein (LysE YggA)
A6035_RS00500	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6035_RS00585	COG1309	transcriptional regulator
A6035_RS00590	COG2239	Acts as a magnesium transporter
A6035_RS00595	COG1309	transcriptional regulator
A6035_RS00605	COG0142	geranyltranstransferase activity
A6035_RS00610	COG0657	acetylesterase activity
A6035_RS00630	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS00640	COG1012	belongs to the aldehyde dehydrogenase family
A6035_RS00645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6035_RS00705	COG0142	geranyltranstransferase activity
A6035_RS00715	COG1309	transcriptional regulator
A6035_RS00720	COG0604	alcohol dehydrogenase
A6035_RS00750	COG1309	transcriptional regulator
A6035_RS00755	COG0477	Major facilitator Superfamily
A6035_RS00760	COG1132	(ABC) transporter
A6035_RS00770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6035_RS00775	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS00865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6035_RS00905	COG0243	molybdopterin cofactor binding
A6035_RS00985	COG0657	acetylesterase activity
A6035_RS01025	COG2801	Transposase and inactivated derivatives
A6035_RS01035	COG4221	oxidoreductase activity
A6035_RS01065	COG1063	alcohol dehydrogenase
A6035_RS01070	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS01090	COG1053	succinate dehydrogenase
A6035_RS01125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A6035_RS01140	COG2801	Transposase and inactivated derivatives
A6035_RS01155	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS01160	COG2365	Tyrosine phosphatase family
A6035_RS01175	COG1074	ATP-dependent DNA helicase activity
A6035_RS01185	COG1309	transcriptional regulator
A6035_RS01230	COG3546	catalase activity
A6035_RS01245	COG1064	alcohol dehydrogenase
A6035_RS01250	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS01265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6035_RS01270	COG1115	amino acid carrier protein
A6035_RS01285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6035_RS01290	COG0175	sulfate reduction
A6035_RS01295	COG1648	precorrin-2 dehydrogenase activity
A6035_RS01295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6035_RS01340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6035_RS01360	COG1403	HNH endonuclease
A6035_RS01370	COG0315	cyclic pyranopterin monophosphate synthase activity
A6035_RS01370	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6035_RS01375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6035_RS01380	COG1902	pentaerythritol trinitrate reductase activity
A6035_RS01400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6035_RS01415	COG0477	Major facilitator Superfamily
A6035_RS01425	COG2233	PERMEase
A6035_RS01430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6035_RS01445	COG2514	catechol 2,3-dioxygenase activity
A6035_RS01460	COG0477	Major facilitator Superfamily
A6035_RS01475	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6035_RS01480	COG1051	belongs to the nudix hydrolase family
A6035_RS01485	COG1045	serine acetyltransferase
A6035_RS01520	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A6035_RS01520	COG0069	glutamate synthase activity
A6035_RS01530	COG1929	Belongs to the glycerate kinase type-1 family
A6035_RS01560	COG0069	glutamate synthase activity
A6035_RS01560	COG0070	glutamate synthase
A6035_RS01560	COG0067	glutamate synthase
A6035_RS01575	COG2501	S4 domain
A6035_RS01590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6035_RS01595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6035_RS01610	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS01615	COG0789	Transcriptional regulator
A6035_RS01620	COG1012	belongs to the aldehyde dehydrogenase family
A6035_RS01745	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6035_RS01750	COG1051	belongs to the nudix hydrolase family
A6035_RS01760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6035_RS01765	COG1278	Cold shock
A6035_RS01770	COG3189	MarR family transcriptional regulator
A6035_RS01795	COG1316	TRANSCRIPTIONal
A6035_RS01815	COG0077	Prephenate dehydratase
A6035_RS01840	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6035_RS01855	COG0561	phosphatase activity
A6035_RS01880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6035_RS01885	COG1216	Glycosyl transferase, family 2
A6035_RS01890	COG0671	phosphoesterase, PA-phosphatase related
A6035_RS01895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6035_RS01905	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6035_RS01920	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
A6035_RS01930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6035_RS01930	COG3321	synthase
A6035_RS01930	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A6035_RS01935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6035_RS01960	COG0277	FAD linked oxidase domain protein
A6035_RS01985	COG1216	Glycosyl transferase, family 2
A6035_RS02025	COG1216	Glycosyl transferase, family 2
A6035_RS02040	COG2130	NADP-dependent
A6035_RS02065	COG3321	synthase
A6035_RS02065	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS02065	COG0604	alcohol dehydrogenase
A6035_RS02090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6035_RS02115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6035_RS02130	COG0737	Belongs to the 5'-nucleotidase family
A6035_RS02135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6035_RS02165	COG1403	HNH endonuclease
A6035_RS02170	COG0697	spore germination
A6035_RS02210	COG0287	Prephenate dehydrogenase
A6035_RS02235	COG1309	transcriptional regulator
A6035_RS02240	COG0343	queuine tRNA-ribosyltransferase activity
A6035_RS02260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6035_RS02295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6035_RS02300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6035_RS02305	COG1034	ATP synthesis coupled electron transport
A6035_RS02320	COG0649	NAD binding
A6035_RS02325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6035_RS02330	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6035_RS02355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6035_RS02365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6035_RS02370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6035_RS02380	COG1492	cobalamin metabolic process
A6035_RS02385	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6035_RS02395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6035_RS02405	COG1950	PFAM Membrane protein of
A6035_RS02430	COG0697	spore germination
A6035_RS02440	COG2826	transposase and inactivated derivatives, IS30 family
A6035_RS02455	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6035_RS02480	COG0346	lactoylglutathione lyase activity
A6035_RS02485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6035_RS02490	COG3119	arylsulfatase activity
A6035_RS02495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6035_RS02510	COG1061	Type III restriction enzyme res subunit
A6035_RS02515	COG0494	nUDIX hydrolase
A6035_RS02530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6035_RS02535	COG0174	glutamine synthetase
A6035_RS02540	COG1053	succinate dehydrogenase
A6035_RS02560	COG2184	nucleotidyltransferase activity
A6035_RS02580	COG0156	8-amino-7-oxononanoate synthase activity
A6035_RS02585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6035_RS02590	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6035_RS02615	COG3708	Transcriptional regulator
A6035_RS02615	COG2207	Transcriptional regulator
A6035_RS02620	COG0477	Major facilitator Superfamily
A6035_RS02630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6035_RS02635	COG3764	Sortase (surface protein transpeptidase)
A6035_RS02650	COG2197	response regulator
A6035_RS02660	COG0589	response to stress
A6035_RS02675	COG0783	Belongs to the Dps family
A6035_RS02690	COG2239	Acts as a magnesium transporter
A6035_RS02710	COG0651	ATP synthesis coupled electron transport
A6035_RS02715	COG1006	Multisubunit Na H antiporter MnhC subunit
A6035_RS02720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6035_RS02720	COG2111	Na H antiporter
A6035_RS02775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6035_RS02795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6035_RS02820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6035_RS02880	COG1205	dead DEAH box helicase
A6035_RS02880	COG1111	helicase
A6035_RS02900	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6035_RS02905	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6035_RS02905	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6035_RS02910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6035_RS02910	COG1754	DNA topoisomerase type I activity
A6035_RS02920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6035_RS02945	COG1024	Enoyl-CoA hydratase
A6035_RS02955	COG1960	acyl-CoA dehydrogenase activity
A6035_RS02960	COG1960	acyl-CoA dehydrogenase activity
A6035_RS02970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6035_RS02995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6035_RS03105	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6035_RS03110	COG2027	D-alanyl-D-alanine carboxypeptidase
A6035_RS03115	COG0037	tRNA processing
A6035_RS03120	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A6035_RS03135	COG1595	DNA-templated transcription, initiation
A6035_RS03150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6035_RS03165	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6035_RS03190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6035_RS03195	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A6035_RS03200	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6035_RS03210	COG3384	dioxygenase
A6035_RS03220	COG2066	Belongs to the glutaminase family
A6035_RS03225	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6035_RS03235	COG1643	Atp-dependent helicase
A6035_RS03260	COG1194	a g-specific adenine glycosylase
A6035_RS03265	COG0288	reversible hydration of carbon dioxide
A6035_RS03275	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
A6035_RS03280	COG2847	Copper chaperone PCu(A)C
A6035_RS03290	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6035_RS03295	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6035_RS03315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6035_RS03320	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6035_RS03325	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6035_RS03335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6035_RS03340	COG0765	amino acid transport
A6035_RS03345	COG0765	amino acid transport
A6035_RS03350	COG1126	abc transporter atp-binding protein
A6035_RS03355	COG0154	amidase activity
A6035_RS03360	COG1802	Transcriptional regulator
A6035_RS03365	COG2197	response regulator
A6035_RS03380	COG0277	FAD linked oxidase domain protein
A6035_RS03380	COG0247	lactate metabolic process
A6035_RS03385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6035_RS03390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6035_RS03395	COG5285	phytanoyl-CoA dioxygenase
A6035_RS03400	COG0583	DNA-binding transcription factor activity
A6035_RS03405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6035_RS03410	COG1309	transcriptional regulator
A6035_RS03415	COG1960	acyl-CoA dehydrogenase activity
A6035_RS03420	COG1960	acyl-CoA dehydrogenase activity
A6035_RS03425	COG2030	dehydratase
A6035_RS03435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6035_RS03460	COG0366	Alpha amylase catalytic
A6035_RS03475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6035_RS03480	COG2030	dehydratase
A6035_RS03485	COG1053	succinate dehydrogenase
A6035_RS03490	COG3971	2-oxopent-4-enoate hydratase activity
A6035_RS03495	COG1414	Transcriptional regulator
A6035_RS03500	COG1403	HNH endonuclease
A6035_RS03505	COG4569	acetaldehyde dehydrogenase (acetylating) activity
A6035_RS03510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6035_RS03520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6035_RS03530	COG4638	Rieske (2fe-2S)
A6035_RS03535	COG1960	acyl-CoA dehydrogenase activity
A6035_RS03540	COG0346	lactoylglutathione lyase activity
A6035_RS03545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6035_RS03560	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6035_RS03565	COG1960	acyl-CoA dehydrogenase activity
A6035_RS03570	COG1960	acyl-CoA dehydrogenase activity
A6035_RS03575	COG1960	acyl-CoA dehydrogenase activity
A6035_RS03580	COG1024	Enoyl-CoA hydratase
A6035_RS03590	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS03595	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS03600	COG1960	acyl-CoA dehydrogenase activity
A6035_RS03605	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS03610	COG1309	transcriptional regulator
A6035_RS03615	COG0183	Belongs to the thiolase family
A6035_RS03645	COG1024	Enoyl-CoA hydratase
A6035_RS03650	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS03655	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS03675	COG0183	Belongs to the thiolase family
A6035_RS03680	COG2124	cytochrome p450
A6035_RS03685	COG0596	Alpha beta hydrolase
A6035_RS03715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6035_RS03725	COG1012	belongs to the aldehyde dehydrogenase family
A6035_RS03730	COG2205	protein histidine kinase activity
A6035_RS03750	COG1024	Enoyl-CoA hydratase
A6035_RS03760	COG2070	2-Nitropropane dioxygenase
A6035_RS03770	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS03775	COG1960	acyl-CoA dehydrogenase activity
A6035_RS03780	COG1960	acyl-CoA dehydrogenase activity
A6035_RS03795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6035_RS03800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6035_RS03825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6035_RS03845	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A6035_RS03875	COG0537	adenosine 5'-monophosphoramidase activity
A6035_RS03890	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A6035_RS03895	COG1960	acyl-CoA dehydrogenase activity
A6035_RS03900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6035_RS03910	COG0471	metal ion transport
A6035_RS03915	COG0436	Aminotransferase
A6035_RS03925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6035_RS03935	COG2267	carboxylic ester hydrolase activity
A6035_RS03940	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6035_RS03960	COG0386	Belongs to the glutathione peroxidase family
A6035_RS03970	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6035_RS03975	COG0047	phosphoribosylformylglycinamidine synthase activity
A6035_RS03985	COG3268	Saccharopine dehydrogenase
A6035_RS04020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6035_RS04035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6035_RS04040	COG4044	May play a role in the intracellular transport of hydrophobic ligands
A6035_RS04060	COG0745	RESPONSE REGULATOR receiver
A6035_RS04065	COG0456	acetyltransferase
A6035_RS04065	COG0454	-acetyltransferase
A6035_RS04080	COG0581	inorganic phosphate transmembrane transporter activity
A6035_RS04085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6035_RS04135	COG2197	response regulator
A6035_RS04145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6035_RS04210	COG0183	Belongs to the thiolase family
A6035_RS04215	COG1024	Enoyl-CoA hydratase
A6035_RS04215	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6035_RS04230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6035_RS04235	COG1120	ATPase activity
A6035_RS04270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6035_RS04280	COG2223	nitrite transmembrane transporter activity
A6035_RS04285	COG0243	molybdopterin cofactor binding
A6035_RS04290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6035_RS04305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6035_RS04305	COG2146	nitrite reductase [NAD(P)H] activity
A6035_RS04315	COG1061	Type III restriction enzyme res subunit
A6035_RS04330	COG1652	LysM domain
A6035_RS04340	COG1278	Cold shock
A6035_RS04350	COG2814	Major facilitator Superfamily
A6035_RS04370	COG2252	PERMEase
A6035_RS04375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6035_RS04395	COG0259	pyridoxamine-phosphate oxidase activity
A6035_RS04405	COG0545	Peptidyl-prolyl cis-trans isomerase
A6035_RS04420	COG1024	Enoyl-CoA hydratase
A6035_RS04435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6035_RS04470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6035_RS04480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6035_RS04500	COG0456	acetyltransferase
A6035_RS04505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6035_RS04520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6035_RS04525	COG0459	protein refolding
A6035_RS04565	COG0519	Catalyzes the synthesis of GMP from XMP
A6035_RS04565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6035_RS04630	COG0587	DNA-directed DNA polymerase activity
A6035_RS04640	COG0277	FAD linked oxidase domain protein
A6035_RS04655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6035_RS04660	COG1121	(ABC) transporter
A6035_RS04665	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6035_RS04670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6035_RS04695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6035_RS04700	COG2873	o-acetylhomoserine
A6035_RS04710	COG0385	Bile acid
A6035_RS04715	COG2814	Major facilitator Superfamily
A6035_RS04730	COG1414	Transcriptional regulator
A6035_RS04735	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6035_RS04740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6035_RS04745	COG0066	3-isopropylmalate dehydratase activity
A6035_RS04755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6035_RS04760	COG0180	Tryptophanyl-tRNA synthetase
A6035_RS04765	COG0328	RNA-DNA hybrid ribonuclease activity
A6035_RS04780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6035_RS04780	COG1017	nitric oxide dioxygenase activity
A6035_RS04790	COG1686	Belongs to the peptidase S11 family
A6035_RS04795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6035_RS04800	COG1053	succinate dehydrogenase
A6035_RS04810	COG2009	succinate dehydrogenase
A6035_RS04840	COG0791	NLP P60 protein
A6035_RS04855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6035_RS04875	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6035_RS04880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6035_RS04885	COG4770	biotin carboxylase activity
A6035_RS04905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6035_RS04910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6035_RS04910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6035_RS04940	COG1316	TRANSCRIPTIONal
A6035_RS04950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6035_RS04955	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A6035_RS04955	COG0778	Nitroreductase
A6035_RS04960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6035_RS04980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6035_RS04990	COG1482	cell wall glycoprotein biosynthetic process
A6035_RS04995	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6035_RS05005	COG0745	RESPONSE REGULATOR receiver
A6035_RS05010	COG5002	protein histidine kinase activity
A6035_RS05015	COG5401	PFAM Sporulation and spore germination
A6035_RS05025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6035_RS05030	COG0653	protein targeting
A6035_RS05040	COG1011	Hydrolase
A6035_RS05060	COG1162	GTPase activity
A6035_RS05065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6035_RS05080	COG1595	DNA-templated transcription, initiation
A6035_RS05090	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A6035_RS05110	COG0513	Belongs to the DEAD box helicase family
A6035_RS05155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6035_RS05175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6035_RS05195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6035_RS05200	COG1615	UPF0182 protein
A6035_RS05225	COG1024	Enoyl-CoA hydratase
A6035_RS05230	COG2072	flavoprotein involved in K transport
A6035_RS05235	COG1960	acyl-CoA dehydrogenase activity
A6035_RS05240	COG1309	transcriptional regulator
A6035_RS05250	COG1960	acyl-CoA dehydrogenase activity
A6035_RS05255	COG1960	acyl-CoA dehydrogenase activity
A6035_RS05260	COG0483	inositol monophosphate 1-phosphatase activity
A6035_RS05265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6035_RS05270	COG0668	transmembrane transport
A6035_RS05280	COG2884	Cell division ATP-binding protein ftsE
A6035_RS05285	COG2177	Part of the ABC transporter FtsEX involved in
A6035_RS05305	COG1403	HNH endonuclease
A6035_RS05345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6035_RS05360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6035_RS05380	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6035_RS05400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6035_RS05405	COG1234	tRNA 3'-trailer cleavage
A6035_RS05410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6035_RS05415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6035_RS05435	COG2340	Cysteine-rich secretory protein family
A6035_RS05445	COG3265	gluconokinase activity
A6035_RS05455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6035_RS05465	COG0733	neurotransmitter:sodium symporter activity
A6035_RS05475	COG2030	dehydratase
A6035_RS05480	COG0736	holo-[acyl-carrier-protein] synthase activity
A6035_RS05505	COG1376	ErfK ybiS ycfS ynhG family protein
A6035_RS05530	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A6035_RS05535	COG0300	oxidoreductase activity
A6035_RS05545	COG0546	phosphoglycolate phosphatase activity
A6035_RS05550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6035_RS05560	COG3336	cytochrome c oxidase
A6035_RS05605	COG0366	Alpha amylase catalytic
A6035_RS05625	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A6035_RS05650	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6035_RS05655	COG0740	serine-type endopeptidase activity
A6035_RS05660	COG0740	serine-type endopeptidase activity
A6035_RS05665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6035_RS05685	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS05700	COG4638	Rieske (2fe-2S)
A6035_RS05705	COG3485	protocatechuate 3,4-dioxygenase
A6035_RS05710	COG4948	Mandelate Racemase Muconate Lactonizing
A6035_RS05715	COG4829	muconolactone delta-isomerase
A6035_RS05725	COG1414	Transcriptional regulator
A6035_RS05745	COG0039	L-malate dehydrogenase activity
A6035_RS05750	COG0525	valine-tRNA ligase activity
A6035_RS05755	COG0285	dihydrofolate synthase activity
A6035_RS05765	COG0105	UTP biosynthetic process
A6035_RS05770	COG1530	ribonuclease E activity
A6035_RS05780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6035_RS05785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6035_RS05790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6035_RS05795	COG0288	reversible hydration of carbon dioxide
A6035_RS05815	COG3573	Dehydrogenase
A6035_RS05820	COG0530	calcium, potassium:sodium antiporter activity
A6035_RS05835	COG4106	trans-aconitate 2-methyltransferase activity
A6035_RS05845	COG2197	response regulator
A6035_RS05860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6035_RS05865	COG0542	response to heat
A6035_RS05875	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6035_RS05890	COG1307	EDD domain protein, DegV family
A6035_RS05895	COG1555	photosystem II stabilization
A6035_RS05905	COG0514	ATP-dependent DNA helicase (RecQ)
A6035_RS05910	COG2080	2 iron, 2 sulfur cluster binding
A6035_RS05915	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6035_RS05920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6035_RS05935	COG4221	oxidoreductase activity
A6035_RS05940	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS05950	COG0268	Binds directly to 16S ribosomal RNA
A6035_RS05965	COG0481	GTPase activity
A6035_RS05980	COG0339	signal peptide processing
A6035_RS06000	COG1420	regulation of RNA biosynthetic process
A6035_RS06005	COG0484	heat shock protein binding
A6035_RS06035	COG1381	Involved in DNA repair and RecF pathway recombination
A6035_RS06040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6035_RS06055	COG0423	glycine-tRNA ligase activity
A6035_RS06080	COG0358	DNA primase activity
A6035_RS06115	COG0657	acetylesterase activity
A6035_RS06120	COG1131	(ABC) transporter
A6035_RS06145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6035_RS06150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6035_RS06160	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6035_RS06205	COG3323	Protein of unknown function (DUF1653)
A6035_RS06205	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6035_RS06230	COG2072	flavoprotein involved in K transport
A6035_RS06245	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6035_RS06250	COG0174	glutamine synthetase
A6035_RS06255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6035_RS06285	COG0174	glutamine synthetase
A6035_RS06300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6035_RS06305	COG0321	lipoyl(octanoyl) transferase activity
A6035_RS06310	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6035_RS06325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6035_RS06330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6035_RS06340	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A6035_RS06355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6035_RS06365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6035_RS06390	COG1053	succinate dehydrogenase
A6035_RS06395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6035_RS06400	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6035_RS06415	COG1845	cytochrome c oxidase, subunit III
A6035_RS06420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6035_RS06445	COG0438	transferase activity, transferring glycosyl groups
A6035_RS06450	COG1022	Amp-dependent synthetase and ligase
A6035_RS06475	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6035_RS06495	COG0142	geranyltranstransferase activity
A6035_RS06545	COG0768	penicillin binding
A6035_RS06565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6035_RS06575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6035_RS06580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6035_RS06585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6035_RS06590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6035_RS06600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6035_RS06615	COG3599	regulation of cell shape
A6035_RS06625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6035_RS06635	COG0252	asparaginase activity
A6035_RS06650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6035_RS06690	COG1739	Uncharacterized protein family UPF0029
A6035_RS06775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6035_RS06830	COG2315	Protein conserved in bacteria
A6035_RS06840	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A6035_RS06845	COG0076	glutamate decarboxylase activity
A6035_RS06850	COG4607	ABC-type enterochelin transport system periplasmic component
A6035_RS06855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6035_RS06860	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6035_RS06865	COG1120	ATPase activity
A6035_RS06885	COG1122	ATPase activity
A6035_RS06890	COG1268	BioY protein
A6035_RS06910	COG3634	alkyl hydroperoxide reductase activity
A6035_RS06955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6035_RS06965	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6035_RS06970	COG0483	inositol monophosphate 1-phosphatase activity
A6035_RS06975	COG0107	imidazoleglycerol-phosphate synthase activity
A6035_RS06990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6035_RS07015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6035_RS07020	COG0469	pyruvate kinase activity
A6035_RS07060	COG0765	amino acid transport
A6035_RS07065	COG1126	abc transporter atp-binding protein
A6035_RS07075	COG0539	negative regulation of cytoplasmic translation
A6035_RS07080	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A6035_RS07080	COG0237	dephospho-CoA kinase activity
A6035_RS07110	COG3973	AAA domain
A6035_RS07140	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6035_RS07150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6035_RS07155	COG0488	(ABC) transporter
A6035_RS07160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6035_RS07165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6035_RS07165	COG0072	phenylalanine-tRNA ligase activity
A6035_RS07170	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6035_RS07170	COG0352	thiamine-phosphate diphosphorylase activity
A6035_RS07170	COG0351	phosphomethylpyrimidine kinase
A6035_RS07180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6035_RS07195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6035_RS07210	COG1438	arginine binding
A6035_RS07220	COG0165	Argininosuccinate lyase
A6035_RS07230	COG2094	Belongs to the DNA glycosylase MPG family
A6035_RS07235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6035_RS07260	COG0647	UMP catabolic process
A6035_RS07300	COG0494	nUDIX hydrolase
A6035_RS07315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6035_RS07320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6035_RS07330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6035_RS07335	COG1160	GTP binding
A6035_RS07375	COG0653	protein targeting
A6035_RS07390	COG1716	ATPase activity
A6035_RS07410	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6035_RS07410	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6035_RS07420	COG0596	Alpha beta hydrolase
A6035_RS07425	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS07455	COG1309	transcriptional regulator
A6035_RS07465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6035_RS07490	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6035_RS07495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6035_RS07495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6035_RS07560	COG0756	dUTP diphosphatase activity
A6035_RS07590	COG0450	alkyl hydroperoxide reductase
A6035_RS07605	COG0513	Belongs to the DEAD box helicase family
A6035_RS07610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6035_RS07625	COG1252	NADH dehydrogenase
A6035_RS07630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6035_RS07670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6035_RS07675	COG1063	alcohol dehydrogenase
A6035_RS07705	COG1690	Belongs to the RtcB family
A6035_RS07720	COG1846	Transcriptional regulator
A6035_RS07730	COG0488	(ABC) transporter
A6035_RS07750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6035_RS07795	COG0300	oxidoreductase activity
A6035_RS07810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6035_RS07825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6035_RS07840	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A6035_RS07855	COG1222	aaa ATPase
A6035_RS07875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6035_RS07880	COG0140	phosphoribosyl-ATP diphosphatase activity
A6035_RS07895	COG0646	methionine synthase
A6035_RS07895	COG1410	methionine synthase
A6035_RS07905	COG0215	cysteine-tRNA ligase activity
A6035_RS07925	COG1968	undecaprenyl-diphosphatase activity
A6035_RS07970	COG1957	nucleoside hydrolase
A6035_RS07975	COG0492	ferredoxin-NADP+ reductase activity
A6035_RS07990	COG4941	Belongs to the sigma-70 factor family
A6035_RS08025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6035_RS08030	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6035_RS08040	COG2304	oxidoreductase activity
A6035_RS08050	COG0714	Associated with various cellular activities
A6035_RS08055	COG0791	NLP P60 protein
A6035_RS08055	COG3883	PFAM NLP P60 protein
A6035_RS08065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6035_RS08070	COG1309	transcriptional regulator
A6035_RS08085	COG0076	glutamate decarboxylase activity
A6035_RS08105	COG0488	(ABC) transporter
A6035_RS08120	COG2151	metal-sulfur cluster biosynthetic enzyme
A6035_RS08135	COG0396	ATPase activity
A6035_RS08160	COG1131	(ABC) transporter
A6035_RS08185	COG0109	protoheme IX farnesyltransferase activity
A6035_RS08190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6035_RS08210	COG0363	glucosamine-6-phosphate deaminase activity
A6035_RS08215	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6035_RS08220	COG0149	triose-phosphate isomerase activity
A6035_RS08225	COG0126	phosphoglycerate kinase activity
A6035_RS08230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6035_RS08235	COG1481	regulation of sporulation
A6035_RS08245	COG1660	Displays ATPase and GTPase activities
A6035_RS08250	COG0322	excinuclease ABC activity
A6035_RS08260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6035_RS08265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6035_RS08265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6035_RS08295	COG0242	peptide deformylase activity
A6035_RS08305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6035_RS08320	COG0194	GDP metabolic process
A6035_RS08335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6035_RS08360	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6035_RS08375	COG0006	proline dipeptidase activity
A6035_RS08380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6035_RS08385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6035_RS08390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6035_RS08395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6035_RS08400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6035_RS08405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6035_RS08410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6035_RS08425	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6035_RS08435	COG0124	histidyl-tRNA synthetase
A6035_RS08440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6035_RS08445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6035_RS08450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6035_RS08460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6035_RS08465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6035_RS08475	COG2255	four-way junction helicase activity
A6035_RS08480	COG0632	four-way junction helicase activity
A6035_RS08485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6035_RS08495	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A6035_RS08500	COG1946	Acyl-CoA thioesterase
A6035_RS08505	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A6035_RS08525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6035_RS08535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6035_RS08540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A6035_RS08595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6035_RS08605	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A6035_RS08610	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6035_RS08625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6035_RS08630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6035_RS08635	COG0531	amino acid
A6035_RS08640	COG0569	domain protein
A6035_RS08660	COG1643	Atp-dependent helicase
A6035_RS08680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6035_RS08690	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6035_RS08695	COG1414	Transcriptional regulator
A6035_RS08700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6035_RS08710	COG1196	nuclear chromosome segregation
A6035_RS08720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6035_RS08730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6035_RS08740	COG1842	Phage shock protein A
A6035_RS08745	COG1396	sequence-specific DNA binding
A6035_RS08750	COG1546	Belongs to the CinA family
A6035_RS08750	COG1058	Belongs to the CinA family
A6035_RS08765	COG1674	ftsk spoiiie
A6035_RS08775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A6035_RS08780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6035_RS08800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6035_RS08825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6035_RS08835	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A6035_RS08845	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6035_RS08850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6035_RS08855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6035_RS08855	COG0481	GTPase activity
A6035_RS08870	COG0779	Required for maturation of 30S ribosomal subunits
A6035_RS08885	COG0442	prolyl-tRNA aminoacylation
A6035_RS08890	COG3022	response to hydroperoxide
A6035_RS08895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6035_RS08900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6035_RS08900	COG1648	precorrin-2 dehydrogenase activity
A6035_RS08905	COG0579	oxidoreductase
A6035_RS08920	COG2072	flavoprotein involved in K transport
A6035_RS08940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6035_RS08945	COG0750	zinc metalloprotease
A6035_RS08950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6035_RS08975	COG0233	cytoplasmic translational termination
A6035_RS08985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6035_RS08990	COG0052	Belongs to the universal ribosomal protein uS2 family
A6035_RS09015	COG0792	nuclease activity
A6035_RS09025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6035_RS09030	COG0681	Belongs to the peptidase S26 family
A6035_RS09035	COG0335	large ribosomal subunit rRNA binding
A6035_RS09040	COG0336	Belongs to the RNA methyltransferase TrmD family
A6035_RS09045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6035_RS09065	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6035_RS09085	COG1196	nuclear chromosome segregation
A6035_RS09090	COG1254	Belongs to the acylphosphatase family
A6035_RS09100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6035_RS09105	COG0571	ribonuclease III activity
A6035_RS09125	COG0742	ribosomal rna small subunit methyltransferase
A6035_RS09130	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6035_RS09135	COG1461	Dihydroxyacetone kinase
A6035_RS09140	COG1024	Enoyl-CoA hydratase
A6035_RS09145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6035_RS09150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6035_RS09165	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6035_RS09170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6035_RS09175	COG1920	GTP binding
A6035_RS09180	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6035_RS09185	COG0406	alpha-ribazole phosphatase activity
A6035_RS09185	COG0494	nUDIX hydrolase
A6035_RS09195	COG0066	3-isopropylmalate dehydratase activity
A6035_RS09200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6035_RS09220	COG1309	transcriptional regulator
A6035_RS09245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6035_RS09255	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6035_RS09270	COG0473	3-isopropylmalate dehydrogenase activity
A6035_RS09285	COG1233	COG1233 Phytoene dehydrogenase and related
A6035_RS09295	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6035_RS09300	COG0440	acetolactate synthase activity
A6035_RS09320	COG0129	dihydroxy-acid dehydratase activity
A6035_RS09335	COG1403	HNH endonuclease
A6035_RS09340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6035_RS09345	COG0205	6-phosphofructokinase activity
A6035_RS09355	COG0154	amidase activity
A6035_RS09360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6035_RS09370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6035_RS09385	COG0482	sulfurtransferase activity
A6035_RS09395	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A6035_RS09405	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS09425	COG1119	ATPase activity
A6035_RS09430	COG0366	Alpha amylase catalytic
A6035_RS09435	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6035_RS09445	COG0183	Belongs to the thiolase family
A6035_RS09465	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A6035_RS09485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6035_RS09490	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6035_RS09495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6035_RS09500	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6035_RS09505	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6035_RS09510	COG0356	it plays a direct role in the translocation of protons across the membrane
A6035_RS09530	COG2890	protein-(glutamine-N5) methyltransferase activity
A6035_RS09535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6035_RS09545	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS09555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6035_RS09560	COG0460	homoserine dehydrogenase
A6035_RS09600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6035_RS09615	COG0477	Major facilitator Superfamily
A6035_RS09645	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6035_RS09645	COG0567	Dehydrogenase, E1 component
A6035_RS09665	COG2301	Belongs to the HpcH HpaI aldolase family
A6035_RS09695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6035_RS09700	COG5662	AntiSigma factor
A6035_RS09715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6035_RS09720	COG0297	glycogen (starch) synthase activity
A6035_RS09730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6035_RS09745	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6035_RS09750	COG1611	Belongs to the LOG family
A6035_RS09760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6035_RS09780	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6035_RS09800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A6035_RS09805	COG0747	negative chemotaxis
A6035_RS09810	COG1217	gtp-binding protein TYPA
A6035_RS09825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6035_RS09835	COG0427	acetyl-CoA hydrolase
A6035_RS09840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6035_RS09845	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6035_RS09875	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6035_RS09880	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A6035_RS09880	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A6035_RS09890	COG2814	Major facilitator Superfamily
A6035_RS09905	COG2354	Protein conserved in bacteria
A6035_RS09915	COG4044	May play a role in the intracellular transport of hydrophobic ligands
A6035_RS09920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6035_RS09925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6035_RS09930	COG1116	anion transmembrane transporter activity
A6035_RS09930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6035_RS09950	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS09955	COG0129	dihydroxy-acid dehydratase activity
A6035_RS09990	COG0564	pseudouridine synthase activity
A6035_RS10010	COG3360	Dodecin
A6035_RS10020	COG1132	(ABC) transporter
A6035_RS10025	COG1132	(ABC) transporter
A6035_RS10055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6035_RS10065	COG0582	viral genome integration into host DNA
A6035_RS10105	COG0012	GTP binding
A6035_RS10120	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6035_RS10130	COG1570	exodeoxyribonuclease VII activity
A6035_RS10145	COG1494	fructose-1,6-bisphosphatase
A6035_RS10155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6035_RS10195	COG1960	acyl-CoA dehydrogenase activity
A6035_RS10200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6035_RS10215	COG0183	Belongs to the thiolase family
A6035_RS10225	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS10235	COG0477	Major facilitator Superfamily
A6035_RS10240	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS10245	COG1309	transcriptional regulator
A6035_RS10255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6035_RS10260	COG1072	(Pantothenic acid kinase))
A6035_RS10290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6035_RS10295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6035_RS10335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A6035_RS10350	COG1401	restriction endodeoxyribonuclease activity
A6035_RS10360	COG2755	lipolytic protein G-D-S-L family
A6035_RS10365	COG0183	Belongs to the thiolase family
A6035_RS10390	COG1131	(ABC) transporter
A6035_RS10420	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A6035_RS10425	COG3639	organic phosphonate transmembrane transporter activity
A6035_RS10445	COG0477	Major facilitator Superfamily
A6035_RS10465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6035_RS10470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6035_RS10475	COG1120	ATPase activity
A6035_RS10505	COG2264	protein methyltransferase activity
A6035_RS10510	COG3973	AAA domain
A6035_RS10530	COG1937	Protein conserved in bacteria
A6035_RS10535	COG1309	transcriptional regulator
A6035_RS10610	COG4942	peptidase
A6035_RS10635	COG2801	Transposase and inactivated derivatives
A6035_RS10670	COG0148	phosphopyruvate hydratase activity
A6035_RS10675	COG0789	Transcriptional regulator
A6035_RS10700	COG1132	(ABC) transporter
A6035_RS10705	COG1132	(ABC) transporter
A6035_RS10750	COG1304	FMN binding
A6035_RS10760	COG3956	TIGRFAM MazG family protein
A6035_RS10785	COG0028	Belongs to the TPP enzyme family
A6035_RS10795	COG0477	Major facilitator Superfamily
A6035_RS10815	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6035_RS10830	COG0193	aminoacyl-tRNA hydrolase activity
A6035_RS10845	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6035_RS10850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6035_RS10865	COG0628	permease
A6035_RS10875	COG2326	polyphosphate kinase activity
A6035_RS10900	COG0488	(ABC) transporter
A6035_RS10905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6035_RS10910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6035_RS10915	COG3583	domain protein
A6035_RS10920	COG0084	hydrolase, TatD family'
A6035_RS10925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6035_RS10930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6035_RS10950	COG0668	transmembrane transport
A6035_RS11005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6035_RS11010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6035_RS11025	COG1970	mechanosensitive ion channel activity
A6035_RS11035	COG0315	cyclic pyranopterin monophosphate synthase activity
A6035_RS11035	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6035_RS11040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6035_RS11045	COG2205	protein histidine kinase activity
A6035_RS11060	COG0254	rRNA binding
A6035_RS11065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6035_RS11070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6035_RS11075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6035_RS11080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6035_RS11105	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS11115	COG2030	dehydratase
A6035_RS11120	COG1960	acyl-CoA dehydrogenase activity
A6035_RS11130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6035_RS11155	COG1131	(ABC) transporter
A6035_RS11205	COG4942	peptidase
A6035_RS11220	COG1115	amino acid carrier protein
A6035_RS11235	COG0166	Belongs to the GPI family
A6035_RS11250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6035_RS11260	COG1201	RNA secondary structure unwinding
A6035_RS11265	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6035_RS11290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6035_RS11315	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS11330	COG0535	radical SAM domain protein
A6035_RS11370	COG0346	lactoylglutathione lyase activity
A6035_RS11375	COG2301	Belongs to the HpcH HpaI aldolase family
A6035_RS11385	COG1012	belongs to the aldehyde dehydrogenase family
A6035_RS11405	COG1674	ftsk spoiiie
A6035_RS11415	COG1404	Belongs to the peptidase S8 family
A6035_RS11435	COG0702	epimerase
A6035_RS11450	COG2755	lipolytic protein G-D-S-L family
A6035_RS11455	COG0203	ribosomal protein L17
A6035_RS11460	COG0202	RNA polymerase activity
A6035_RS11470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6035_RS11475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6035_RS11480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6035_RS11495	COG0563	adenylate kinase activity
A6035_RS11500	COG0201	protein transport
A6035_RS11505	COG0200	Binds to the 23S rRNA
A6035_RS11520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6035_RS11540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6035_RS11545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6035_RS11550	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6035_RS11550	COG5479	isomerase activity
A6035_RS11560	COG0255	Belongs to the universal ribosomal protein uL29 family
A6035_RS11575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6035_RS11580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6035_RS11585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6035_RS11595	COG0088	Forms part of the polypeptide exit tunnel
A6035_RS11605	COG0051	transcription antitermination factor activity, RNA binding
A6035_RS11630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6035_RS11660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6035_RS11665	COG1960	acyl-CoA dehydrogenase activity
A6035_RS11680	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS11700	COG0477	Major facilitator Superfamily
A6035_RS11710	COG0859	PFAM glycosyl transferase family 9
A6035_RS11715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6035_RS11715	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6035_RS11720	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6035_RS11730	COG0859	PFAM glycosyl transferase family 9
A6035_RS11740	COG2192	nodulation
A6035_RS11760	COG2124	cytochrome p450
A6035_RS11765	COG2197	response regulator
A6035_RS11785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6035_RS11790	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS11815	COG2124	cytochrome p450
A6035_RS11865	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
A6035_RS11870	COG3304	Inner membrane component domain
A6035_RS11910	COG0438	transferase activity, transferring glycosyl groups
A6035_RS11965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6035_RS11970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6035_RS11985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6035_RS12005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6035_RS12015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6035_RS12035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6035_RS12060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6035_RS12070	COG0081	regulation of translation
A6035_RS12075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6035_RS12100	COG2030	dehydratase
A6035_RS12115	COG0156	8-amino-7-oxononanoate synthase activity
A6035_RS12135	COG1215	transferase activity, transferring glycosyl groups
A6035_RS12155	COG1562	ergosterol biosynthetic process
A6035_RS12160	COG0142	geranyltranstransferase activity
A6035_RS12170	COG1666	GTP binding
A6035_RS12190	COG0142	geranyltranstransferase activity
A6035_RS12205	COG0438	transferase activity, transferring glycosyl groups
A6035_RS12215	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6035_RS12230	COG2318	DinB family
A6035_RS12240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6035_RS12250	COG4948	Mandelate Racemase Muconate Lactonizing
A6035_RS12290	COG4181	ATPase activity
A6035_RS12310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6035_RS12350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6035_RS12355	COG1088	dTDP-glucose 4,6-dehydratase activity
A6035_RS12365	COG1295	ribonuclease BN
A6035_RS12365	COG1959	2 iron, 2 sulfur cluster binding
A6035_RS12370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6035_RS12385	COG1960	acyl-CoA dehydrogenase activity
A6035_RS12395	COG0183	Belongs to the thiolase family
A6035_RS12410	COG1295	ribonuclease BN
A6035_RS12425	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6035_RS12430	COG0730	response to heat
A6035_RS12440	COG0730	response to heat
A6035_RS12450	COG0175	sulfate reduction
A6035_RS12465	COG1012	belongs to the aldehyde dehydrogenase family
A6035_RS12475	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS12500	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS12530	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
A6035_RS12550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6035_RS12555	COG0601	transmembrane transport
A6035_RS12565	COG0444	Belongs to the ABC transporter superfamily
A6035_RS12625	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS12690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6035_RS12695	COG2826	transposase and inactivated derivatives, IS30 family
A6035_RS12700	COG1024	Enoyl-CoA hydratase
A6035_RS12715	COG1764	response to oxidative stress
A6035_RS12775	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A6035_RS12785	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A6035_RS12800	COG4941	Belongs to the sigma-70 factor family
A6035_RS12805	COG3795	YCII-related domain
A6035_RS12895	COG1960	acyl-CoA dehydrogenase activity
A6035_RS12900	COG1960	acyl-CoA dehydrogenase activity
A6035_RS12910	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS12925	COG0824	Thioesterase
A6035_RS12925	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6035_RS12935	COG2130	NADP-dependent
A6035_RS12955	COG0559	Belongs to the binding-protein-dependent transport system permease family
A6035_RS12980	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS13020	COG1073	alpha beta
A6035_RS13020	COG2226	methyltransferase
A6035_RS13050	COG3300	MHYT domain
A6035_RS13050	COG5001	Diguanylate cyclase
A6035_RS13055	COG2267	carboxylic ester hydrolase activity
A6035_RS13065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6035_RS13070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6035_RS13110	COG1484	DNA-dependent DNA replication
A6035_RS13150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6035_RS13155	COG1086	Polysaccharide biosynthesis protein
A6035_RS13160	COG3206	protein involved in exopolysaccharide biosynthesis
A6035_RS13160	COG0489	protein tyrosine kinase activity
A6035_RS13205	COG2197	response regulator
A6035_RS13215	COG1960	acyl-CoA dehydrogenase activity
A6035_RS13220	COG1960	acyl-CoA dehydrogenase activity
A6035_RS13235	COG0477	Major facilitator Superfamily
A6035_RS13240	COG2186	Transcriptional regulator
A6035_RS13275	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A6035_RS13340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6035_RS13350	COG3835	regulator
A6035_RS13355	COG2814	Major facilitator Superfamily
A6035_RS13370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6035_RS13375	COG1333	cytochrome c biogenesis protein
A6035_RS13385	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
A6035_RS13410	COG0785	Cytochrome C biogenesis protein
A6035_RS13420	COG0406	alpha-ribazole phosphatase activity
A6035_RS13455	COG1648	precorrin-2 dehydrogenase activity
A6035_RS13455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6035_RS13460	COG0181	hydroxymethylbilane synthase activity
A6035_RS13465	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6035_RS13525	COG0745	RESPONSE REGULATOR receiver
A6035_RS13530	COG5002	protein histidine kinase activity
A6035_RS13535	COG0588	phosphoglycerate mutase activity
A6035_RS13540	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS13545	COG2826	transposase and inactivated derivatives, IS30 family
A6035_RS13555	COG0438	transferase activity, transferring glycosyl groups
A6035_RS13565	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
A6035_RS13575	COG1528	Iron-storage protein
A6035_RS13580	COG0488	(ABC) transporter
A6035_RS13585	COG0706	membrane insertase activity
A6035_RS13590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6035_RS13630	COG0651	ATP synthesis coupled electron transport
A6035_RS13635	COG1006	Multisubunit Na H antiporter MnhC subunit
A6035_RS13640	COG2111	Na H antiporter
A6035_RS13640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6035_RS13645	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6035_RS13675	COG2733	membrane
A6035_RS13685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6035_RS13695	COG2224	Isocitrate lyase
A6035_RS13720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6035_RS13735	COG1505	serine-type exopeptidase activity
A6035_RS13780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6035_RS13790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6035_RS13790	COG2111	Na H antiporter
A6035_RS13795	COG1006	Multisubunit Na H antiporter MnhC subunit
A6035_RS13800	COG0651	ATP synthesis coupled electron transport
A6035_RS13850	COG2326	polyphosphate kinase activity
A6035_RS13855	COG1832	CoA-binding protein
A6035_RS13875	COG1131	(ABC) transporter
A6035_RS13885	COG2022	thiamine diphosphate biosynthetic process
A6035_RS13900	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS13910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6035_RS13970	COG0667	Aldo Keto reductase
A6035_RS13975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6035_RS14000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6035_RS14005	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A6035_RS14025	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS14030	COG1960	acyl-CoA dehydrogenase activity
A6035_RS14040	COG1960	acyl-CoA dehydrogenase activity
A6035_RS14045	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6035_RS14045	COG0022	dehydrogenase e1 component
A6035_RS14050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6035_RS14065	COG1960	acyl-CoA dehydrogenase activity
A6035_RS14125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6035_RS14180	COG1024	Enoyl-CoA hydratase
A6035_RS14185	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS14185	COG3321	synthase
A6035_RS14185	COG0604	alcohol dehydrogenase
A6035_RS14190	COG1960	acyl-CoA dehydrogenase activity
A6035_RS14205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6035_RS14210	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6035_RS14210	COG0022	dehydrogenase e1 component
A6035_RS14215	COG1960	acyl-CoA dehydrogenase activity
A6035_RS14225	COG1960	acyl-CoA dehydrogenase activity
A6035_RS14230	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS14250	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A6035_RS14255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6035_RS14265	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS14290	COG0352	thiamine-phosphate diphosphorylase activity
A6035_RS14310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6035_RS14315	COG0515	serine threonine protein kinase
A6035_RS14340	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A6035_RS14345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6035_RS14360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6035_RS14385	COG0493	'glutamate synthase
A6035_RS14405	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A6035_RS14415	COG3938	Belongs to the proline racemase family
A6035_RS14420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6035_RS14425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6035_RS14445	COG1984	allophanate hydrolase subunit 2
A6035_RS14455	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6035_RS14465	COG4129	membrane
A6035_RS14485	COG1403	HNH endonuclease
A6035_RS14495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6035_RS14500	COG3655	Transcriptional regulator
A6035_RS14515	COG0300	oxidoreductase activity
A6035_RS14525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6035_RS14580	COG0542	response to heat
A6035_RS14590	COG0778	Nitroreductase
A6035_RS14600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6035_RS14640	COG0789	Transcriptional regulator
A6035_RS14645	COG0484	heat shock protein binding
A6035_RS14655	COG0443	Heat shock 70 kDa protein
A6035_RS14660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6035_RS14670	COG0247	lactate metabolic process
A6035_RS14670	COG2181	nitrate reductase activity
A6035_RS14720	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS14745	COG1960	acyl-CoA dehydrogenase activity
A6035_RS14750	COG0753	catalase activity
A6035_RS14760	COG0183	Belongs to the thiolase family
A6035_RS14765	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS14770	COG2030	dehydratase
A6035_RS14775	COG2133	pyrroloquinoline quinone binding
A6035_RS14785	COG2133	pyrroloquinoline quinone binding
A6035_RS14795	COG0738	Major facilitator superfamily
A6035_RS14805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6035_RS14810	COG2755	lipolytic protein G-D-S-L family
A6035_RS14815	COG2755	lipolytic protein G-D-S-L family
A6035_RS14820	COG2837	iron assimilation
A6035_RS14850	COG1842	Phage shock protein A
A6035_RS14875	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS14890	COG0577	efflux transmembrane transporter activity
A6035_RS14890	COG1136	(ABC) transporter
A6035_RS14895	COG1136	(ABC) transporter
A6035_RS14900	COG0564	pseudouridine synthase activity
A6035_RS14925	COG1309	transcriptional regulator
A6035_RS14950	COG1376	ErfK ybiS ycfS ynhG family protein
A6035_RS14955	COG1376	ErfK ybiS ycfS ynhG family protein
A6035_RS14960	COG1175	transmembrane transport
A6035_RS14970	COG1653	transport
A6035_RS14975	COG3842	ATPase activity
A6035_RS14980	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A6035_RS14995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6035_RS15000	COG3590	peptidase
A6035_RS15040	COG2409	Drug exporters of the RND superfamily
A6035_RS15050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6035_RS15070	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A6035_RS15080	COG2205	protein histidine kinase activity
A6035_RS15090	COG0477	Major facilitator Superfamily
A6035_RS15110	COG0438	transferase activity, transferring glycosyl groups
A6035_RS15145	COG1309	transcriptional regulator
A6035_RS15150	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS15175	COG2070	2-Nitropropane dioxygenase
A6035_RS15190	COG1472	Belongs to the glycosyl hydrolase 3 family
A6035_RS15195	COG0519	Catalyzes the synthesis of GMP from XMP
A6035_RS15205	COG2860	membrane
A6035_RS15215	COG0435	Glutathione S-transferase
A6035_RS15235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A6035_RS15260	COG1917	Cupin 2, conserved barrel domain protein
A6035_RS15265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6035_RS15270	COG0456	acetyltransferase
A6035_RS15315	COG0483	inositol monophosphate 1-phosphatase activity
A6035_RS15320	COG1174	glycine betaine transport
A6035_RS15330	COG1174	glycine betaine transport
A6035_RS15365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6035_RS15395	COG2409	Drug exporters of the RND superfamily
A6035_RS15400	COG0596	Alpha beta hydrolase
A6035_RS15420	COG0463	Glycosyl transferase, family 2
A6035_RS15455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6035_RS15455	COG1648	precorrin-2 dehydrogenase activity
A6035_RS15460	COG1376	ErfK ybiS ycfS ynhG family protein
A6035_RS15465	COG3104	oligopeptide transport
A6035_RS15470	COG1253	flavin adenine dinucleotide binding
A6035_RS15475	COG1253	flavin adenine dinucleotide binding
A6035_RS15495	COG1960	acyl-CoA dehydrogenase activity
A6035_RS15510	COG1595	DNA-templated transcription, initiation
A6035_RS15520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6035_RS15570	COG1247	-acetyltransferase
A6035_RS15580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6035_RS15590	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A6035_RS15600	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A6035_RS15605	COG0431	NADPH-dependent FMN reductase
A6035_RS15615	COG2205	protein histidine kinase activity
A6035_RS15625	COG2197	response regulator
A6035_RS15630	COG4152	abc transporter atp-binding protein
A6035_RS15640	COG0745	RESPONSE REGULATOR receiver
A6035_RS15645	COG1045	serine acetyltransferase
A6035_RS15665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6035_RS15690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6035_RS15705	COG0659	secondary active sulfate transmembrane transporter activity
A6035_RS15715	COG1027	Aspartate ammonia-lyase
A6035_RS15720	COG0671	phosphoesterase, PA-phosphatase related
A6035_RS15725	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A6035_RS15755	COG0765	amino acid transport
A6035_RS15760	COG0765	amino acid transport
A6035_RS15765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6035_RS15770	COG1126	abc transporter atp-binding protein
A6035_RS15795	COG0693	protein deglycase activity
A6035_RS15810	COG0513	Belongs to the DEAD box helicase family
A6035_RS15825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6035_RS15835	COG0351	phosphomethylpyrimidine kinase
A6035_RS15835	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6035_RS15835	COG0352	thiamine-phosphate diphosphorylase activity
A6035_RS15845	COG0569	domain protein
A6035_RS15850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6035_RS15855	COG1595	DNA-templated transcription, initiation
A6035_RS15885	COG0477	Major facilitator Superfamily
A6035_RS15900	COG1309	transcriptional regulator
A6035_RS15940	COG0455	bacterial-type flagellum organization
A6035_RS15980	COG2608	mercury ion transmembrane transporter activity
A6035_RS15985	COG1937	Protein conserved in bacteria
A6035_RS15995	COG0243	molybdopterin cofactor binding
A6035_RS16035	COG3226	Transcriptional regulator
A6035_RS16060	COG4829	muconolactone delta-isomerase
A6035_RS16065	COG4948	Mandelate Racemase Muconate Lactonizing
A6035_RS16070	COG3485	protocatechuate 3,4-dioxygenase
A6035_RS16145	COG1960	acyl-CoA dehydrogenase activity
A6035_RS16155	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS16165	COG0405	Gamma-glutamyltransferase
A6035_RS16170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6035_RS16175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6035_RS16180	COG1120	ATPase activity
A6035_RS16195	COG2409	Drug exporters of the RND superfamily
A6035_RS16200	COG2323	membrane
A6035_RS16250	COG0438	transferase activity, transferring glycosyl groups
A6035_RS16285	COG0657	acetylesterase activity
A6035_RS16305	COG2066	Belongs to the glutaminase family
A6035_RS16310	COG0662	Cupin 2, conserved barrel domain protein
A6035_RS16320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6035_RS16345	COG0386	Belongs to the glutathione peroxidase family
A6035_RS16360	COG1652	LysM domain
A6035_RS16375	COG1840	ABC-type Fe3 transport system, periplasmic component
A6035_RS16385	COG3842	ATPase activity
A6035_RS16390	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS16395	COG2072	flavoprotein involved in K transport
A6035_RS16425	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6035_RS16435	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS16475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6035_RS16480	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A6035_RS16490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6035_RS16490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6035_RS16490	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A6035_RS16495	COG1105	Belongs to the carbohydrate kinase PfkB family
A6035_RS16500	COG1349	DNA-binding transcription factor activity
A6035_RS16505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6035_RS16520	COG1902	pentaerythritol trinitrate reductase activity
A6035_RS16520	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6035_RS16570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6035_RS16575	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6035_RS16590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6035_RS16590	COG1648	precorrin-2 dehydrogenase activity
A6035_RS16645	COG0778	Nitroreductase
A6035_RS16665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6035_RS16670	COG1121	(ABC) transporter
A6035_RS16720	COG1492	cobalamin metabolic process
A6035_RS16740	COG0559	Belongs to the binding-protein-dependent transport system permease family
A6035_RS16745	COG1022	Amp-dependent synthetase and ligase
A6035_RS16760	COG0477	Major facilitator Superfamily
A6035_RS16785	COG0671	phosphoesterase, PA-phosphatase related
A6035_RS16795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6035_RS16805	COG0305	Participates in initiation and elongation during chromosome replication
A6035_RS16810	COG0359	binds to the 23S rRNA
A6035_RS16815	COG0629	single-stranded DNA binding
A6035_RS16835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6035_RS16850	COG1260	myo-inositol-1-phosphate synthase
A6035_RS16860	COG2890	protein-(glutamine-N5) methyltransferase activity
A6035_RS16885	COG3383	formate dehydrogenase (NAD+) activity
A6035_RS16885	COG0243	molybdopterin cofactor binding
A6035_RS16890	COG0437	4 iron, 4 sulfur cluster binding
A6035_RS16905	COG1921	L-seryl-tRNASec selenium transferase activity
A6035_RS16915	COG0709	Synthesizes selenophosphate from selenide and ATP
A6035_RS16920	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A6035_RS16920	COG1473	amidohydrolase
A6035_RS16930	COG2308	Evidence 4 Homologs of previously reported genes of
A6035_RS16930	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A6035_RS16940	COG1024	Enoyl-CoA hydratase
A6035_RS16970	COG0318	PFAM AMP-dependent synthetase and ligase
A6035_RS16975	COG1024	Enoyl-CoA hydratase
A6035_RS16985	COG1024	Enoyl-CoA hydratase
A6035_RS16985	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6035_RS16990	COG0183	Belongs to the thiolase family
A6035_RS16995	COG1309	transcriptional regulator
A6035_RS17015	COG1960	acyl-CoA dehydrogenase activity
A6035_RS17025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6035_RS17050	COG3842	ATPase activity
A6035_RS17070	COG0300	oxidoreductase activity
A6035_RS17075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6035_RS17090	COG3631	Ketosteroid isomerase-related protein
A6035_RS17095	COG0477	Major facilitator Superfamily
A6035_RS17110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6035_RS17115	COG0640	Transcriptional regulator
A6035_RS17125	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS17135	COG2267	carboxylic ester hydrolase activity
A6035_RS17165	COG1028	Short-chain dehydrogenase reductase Sdr
A6035_RS17175	COG0495	leucyl-tRNA aminoacylation
A6035_RS17205	COG2149	membrane
A6035_RS17260	COG2124	cytochrome p450
A6035_RS17270	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A6035_RS17280	COG2271	Major facilitator Superfamily
A6035_RS17285	COG1678	Uncharacterized ACR, COG1678
A6035_RS17305	COG0617	tRNA 3'-terminal CCA addition
A6035_RS17340	COG1595	DNA-templated transcription, initiation
A6035_RS17355	COG3409	Peptidoglycan-binding domain 1 protein
A6035_RS17355	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6035_RS17370	COG1192	Involved in chromosome partitioning
A6035_RS17375	COG0357	Ribosomal RNA small subunit methyltransferase G
A6035_RS17385	COG0706	membrane insertase activity
A6035_RS17390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6035_RS17395	COG0594	ribonuclease P activity
A6035_RS17400	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6035_RS17405	COG1012	belongs to the aldehyde dehydrogenase family
A6035_RS17410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6035_RS17435	COG1012	belongs to the aldehyde dehydrogenase family
A6035_RS17465	COG1960	acyl-CoA dehydrogenase activity
A6035_RS17475	COG0405	Gamma-glutamyltransferase
A6035_RS17490	COG4115	mRNA cleavage
A6035_RS17495	COG2161	toxin-antitoxin pair type II binding
A6035_RS17515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6035_RS17570	COG0477	Major facilitator Superfamily
A6035_RS17575	COG1024	Enoyl-CoA hydratase
A6035_RS17595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6035_RS17605	COG1126	abc transporter atp-binding protein
A6035_RS17610	COG1309	transcriptional regulator
A6035_RS17625	COG1484	DNA-dependent DNA replication
A6035_RS17635	COG4584	PFAM Integrase catalytic