locus-tag	class	description
C3V38_RS00010	COG4604	ABC transporter, ATP-binding protein
C3V38_RS00015	COG4605	iron ion homeostasis
C3V38_RS00020	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V38_RS00025	COG4607	ABC-type enterochelin transport system periplasmic component
C3V38_RS00035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3V38_RS00040	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C3V38_RS00040	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C3V38_RS00055	COG2814	Major facilitator Superfamily
C3V38_RS00065	COG2354	Protein conserved in bacteria
C3V38_RS00085	COG4044	May play a role in the intracellular transport of hydrophobic ligands
C3V38_RS00090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3V38_RS00095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3V38_RS00100	COG1116	anion transmembrane transporter activity
C3V38_RS00100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3V38_RS00120	COG0129	dihydroxy-acid dehydratase activity
C3V38_RS00130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V38_RS00165	COG3360	Dodecin
C3V38_RS00175	COG1132	(ABC) transporter
C3V38_RS00180	COG1132	(ABC) transporter
C3V38_RS00200	COG2814	Major facilitator Superfamily
C3V38_RS00205	COG0564	pseudouridine synthase activity
C3V38_RS00230	COG0583	DNA-binding transcription factor activity
C3V38_RS00240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3V38_RS00265	COG0012	GTP binding
C3V38_RS00280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3V38_RS00290	COG1570	exodeoxyribonuclease VII activity
C3V38_RS00305	COG1494	fructose-1,6-bisphosphatase
C3V38_RS00315	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C3V38_RS00355	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS00365	COG0183	Belongs to the thiolase family
C3V38_RS00370	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS00375	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS00385	COG0477	Major facilitator Superfamily
C3V38_RS00390	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS00405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3V38_RS00410	COG1072	(Pantothenic acid kinase))
C3V38_RS00430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C3V38_RS00435	COG1403	HNH endonuclease
C3V38_RS00445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V38_RS00460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3V38_RS00475	COG1401	restriction endodeoxyribonuclease activity
C3V38_RS00485	COG2755	lipolytic protein G-D-S-L family
C3V38_RS00490	COG0183	Belongs to the thiolase family
C3V38_RS00505	COG1131	(ABC) transporter
C3V38_RS00520	COG0477	Major facilitator Superfamily
C3V38_RS00535	COG2264	protein methyltransferase activity
C3V38_RS00575	COG1937	Protein conserved in bacteria
C3V38_RS00580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3V38_RS00660	COG4942	peptidase
C3V38_RS00700	COG0148	phosphopyruvate hydratase activity
C3V38_RS00725	COG1132	(ABC) transporter
C3V38_RS00730	COG1132	(ABC) transporter
C3V38_RS00770	COG1304	FMN binding
C3V38_RS00775	COG1569	PIN domain
C3V38_RS00780	COG3311	Transcriptional regulator
C3V38_RS00815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3V38_RS00820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3V38_RS00825	COG1309	transcriptional regulator
C3V38_RS00845	COG0028	Belongs to the TPP enzyme family
C3V38_RS00855	COG0477	Major facilitator Superfamily
C3V38_RS00875	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C3V38_RS00890	COG0193	aminoacyl-tRNA hydrolase activity
C3V38_RS00905	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C3V38_RS00910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V38_RS00925	COG0628	permease
C3V38_RS00935	COG2326	polyphosphate kinase activity
C3V38_RS00955	COG0488	(ABC) transporter
C3V38_RS00960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C3V38_RS00965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3V38_RS00970	COG3583	domain protein
C3V38_RS00975	COG0084	hydrolase, TatD family'
C3V38_RS00980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3V38_RS00985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C3V38_RS00990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C3V38_RS01005	COG0668	transmembrane transport
C3V38_RS01050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3V38_RS01060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3V38_RS01065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C3V38_RS01080	COG1970	mechanosensitive ion channel activity
C3V38_RS01090	COG0521	Mo-molybdopterin cofactor biosynthetic process
C3V38_RS01090	COG0315	cyclic pyranopterin monophosphate synthase activity
C3V38_RS01095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3V38_RS01100	COG2205	protein histidine kinase activity
C3V38_RS01115	COG0254	rRNA binding
C3V38_RS01120	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3V38_RS01125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3V38_RS01130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3V38_RS01135	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3V38_RS01160	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS01170	COG2030	dehydratase
C3V38_RS01175	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS01185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3V38_RS01210	COG1131	(ABC) transporter
C3V38_RS01275	COG1115	amino acid carrier protein
C3V38_RS01290	COG0166	Belongs to the GPI family
C3V38_RS01305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3V38_RS01315	COG1201	RNA secondary structure unwinding
C3V38_RS01320	COG1218	3'(2'),5'-bisphosphate nucleotidase
C3V38_RS01345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3V38_RS01370	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS01385	COG0535	radical SAM domain protein
C3V38_RS01425	COG0346	lactoylglutathione lyase activity
C3V38_RS01430	COG2301	Belongs to the HpcH HpaI aldolase family
C3V38_RS01435	COG1012	belongs to the aldehyde dehydrogenase family
C3V38_RS01455	COG1674	ftsk spoiiie
C3V38_RS01465	COG1404	Belongs to the peptidase S8 family
C3V38_RS01485	COG0702	epimerase
C3V38_RS01500	COG2755	lipolytic protein G-D-S-L family
C3V38_RS01505	COG0203	ribosomal protein L17
C3V38_RS01510	COG0202	RNA polymerase activity
C3V38_RS01520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3V38_RS01525	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3V38_RS01530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C3V38_RS01545	COG0563	adenylate kinase activity
C3V38_RS01550	COG0201	protein transport
C3V38_RS01555	COG0200	Binds to the 23S rRNA
C3V38_RS01570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C3V38_RS01585	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3V38_RS01590	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3V38_RS01595	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3V38_RS01600	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C3V38_RS01600	COG5479	isomerase activity
C3V38_RS01610	COG0255	Belongs to the universal ribosomal protein uL29 family
C3V38_RS01625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C3V38_RS01630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C3V38_RS01635	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3V38_RS01645	COG0088	Forms part of the polypeptide exit tunnel
C3V38_RS01650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C3V38_RS01655	COG0051	transcription antitermination factor activity, RNA binding
C3V38_RS01680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3V38_RS01710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3V38_RS01715	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS01750	COG0477	Major facilitator Superfamily
C3V38_RS01755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3V38_RS01760	COG0859	PFAM glycosyl transferase family 9
C3V38_RS01765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C3V38_RS01765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C3V38_RS01770	COG0297	glycogen (starch) synthase activity
C3V38_RS01780	COG0859	PFAM glycosyl transferase family 9
C3V38_RS01790	COG2192	nodulation
C3V38_RS01795	COG1215	transferase activity, transferring glycosyl groups
C3V38_RS01810	COG2124	cytochrome p450
C3V38_RS01815	COG2197	response regulator
C3V38_RS01835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3V38_RS01850	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
C3V38_RS01855	COG3304	Inner membrane component domain
C3V38_RS01885	COG2226	methyltransferase
C3V38_RS01890	COG0438	transferase activity, transferring glycosyl groups
C3V38_RS01900	COG0085	RNA polymerase activity
C3V38_RS01920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C3V38_RS01945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C3V38_RS01950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C3V38_RS01965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C3V38_RS01975	COG0081	regulation of translation
C3V38_RS01980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C3V38_RS02005	COG2030	dehydratase
C3V38_RS02020	COG1215	transferase activity, transferring glycosyl groups
C3V38_RS02040	COG1562	ergosterol biosynthetic process
C3V38_RS02045	COG0142	geranyltranstransferase activity
C3V38_RS02075	COG0142	geranyltranstransferase activity
C3V38_RS02090	COG0438	transferase activity, transferring glycosyl groups
C3V38_RS02100	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C3V38_RS02115	COG2318	DinB family
C3V38_RS02125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3V38_RS02135	COG4948	Mandelate Racemase Muconate Lactonizing
C3V38_RS02175	COG1136	(ABC) transporter
C3V38_RS02195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3V38_RS02240	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C3V38_RS02245	COG1088	dTDP-glucose 4,6-dehydratase activity
C3V38_RS02255	COG1959	2 iron, 2 sulfur cluster binding
C3V38_RS02255	COG1295	ribonuclease BN
C3V38_RS02260	COG1295	ribonuclease BN
C3V38_RS02275	COG1218	3'(2'),5'-bisphosphate nucleotidase
C3V38_RS02280	COG0730	response to heat
C3V38_RS02300	COG0175	sulfate reduction
C3V38_RS02315	COG1012	belongs to the aldehyde dehydrogenase family
C3V38_RS02325	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS02340	COG4585	Histidine kinase
C3V38_RS02375	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
C3V38_RS02475	COG0574	Belongs to the PEP-utilizing enzyme family
C3V38_RS02475	COG3848	Pyruvate phosphate dikinase
C3V38_RS02495	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C3V38_RS02505	COG1764	response to oxidative stress
C3V38_RS02525	COG4941	Belongs to the sigma-70 factor family
C3V38_RS02530	COG3795	YCII-related domain
C3V38_RS02555	COG1120	ATPase activity
C3V38_RS02560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C3V38_RS02565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V38_RS02570	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V38_RS02580	COG1511	domain protein
C3V38_RS02625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3V38_RS02665	COG2267	carboxylic ester hydrolase activity
C3V38_RS02730	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C3V38_RS02760	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C3V38_RS02765	COG2116	formate transmembrane transporter activity
C3V38_RS02845	COG0829	nickel cation binding
C3V38_RS02850	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C3V38_RS02855	COG2814	Major facilitator Superfamily
C3V38_RS02860	COG0830	nickel cation binding
C3V38_RS02865	COG0804	urea catabolic process
C3V38_RS02875	COG0831	urea catabolic process
C3V38_RS02885	COG2351	hydroxyisourate hydrolase activity
C3V38_RS02895	COG2080	2 iron, 2 sulfur cluster binding
C3V38_RS02895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3V38_RS02910	COG0402	S-adenosylhomocysteine deaminase activity
C3V38_RS02915	COG0259	pyridoxamine-phosphate oxidase activity
C3V38_RS02925	COG0277	FAD linked oxidase domain protein
C3V38_RS02945	COG0402	S-adenosylhomocysteine deaminase activity
C3V38_RS02960	COG2072	flavoprotein involved in K transport
C3V38_RS02965	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
C3V38_RS02975	COG4266	Belongs to the allantoicase family
C3V38_RS02980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3V38_RS03005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3V38_RS03015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3V38_RS03020	COG1333	cytochrome c biogenesis protein
C3V38_RS03040	COG0785	Cytochrome C biogenesis protein
C3V38_RS03050	COG0406	alpha-ribazole phosphatase activity
C3V38_RS03090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3V38_RS03090	COG1648	precorrin-2 dehydrogenase activity
C3V38_RS03100	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C3V38_RS03160	COG0745	RESPONSE REGULATOR receiver
C3V38_RS03165	COG5002	protein histidine kinase activity
C3V38_RS03170	COG0588	phosphoglycerate mutase activity
C3V38_RS03175	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS03185	COG0438	transferase activity, transferring glycosyl groups
C3V38_RS03210	COG1528	Iron-storage protein
C3V38_RS03220	COG0706	membrane insertase activity
C3V38_RS03225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C3V38_RS03250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C3V38_RS03280	COG2733	membrane
C3V38_RS03290	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3V38_RS03300	COG2224	Isocitrate lyase
C3V38_RS03320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3V38_RS03335	COG1505	serine-type exopeptidase activity
C3V38_RS03380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3V38_RS03390	COG2111	Na H antiporter
C3V38_RS03390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3V38_RS03395	COG1006	Multisubunit Na H antiporter MnhC subunit
C3V38_RS03400	COG0651	ATP synthesis coupled electron transport
C3V38_RS03410	COG2212	antiporter activity
C3V38_RS03450	COG2326	polyphosphate kinase activity
C3V38_RS03455	COG1832	CoA-binding protein
C3V38_RS03475	COG1131	(ABC) transporter
C3V38_RS03485	COG2022	thiamine diphosphate biosynthetic process
C3V38_RS03520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3V38_RS03525	COG0515	serine threonine protein kinase
C3V38_RS03555	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C3V38_RS03570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V38_RS03615	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C3V38_RS03625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3V38_RS03630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3V38_RS03645	COG1984	allophanate hydrolase subunit 2
C3V38_RS03655	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C3V38_RS03665	COG4129	membrane
C3V38_RS03690	COG1403	HNH endonuclease
C3V38_RS03705	COG3655	Transcriptional regulator
C3V38_RS03720	COG0300	oxidoreductase activity
C3V38_RS03730	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3V38_RS03745	COG0542	response to heat
C3V38_RS03755	COG0778	Nitroreductase
C3V38_RS03765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3V38_RS03810	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS03815	COG3842	ATPase activity
C3V38_RS03830	COG2801	Transposase and inactivated derivatives
C3V38_RS03830	COG3415	Transposase
C3V38_RS03835	COG0789	Transcriptional regulator
C3V38_RS03840	COG0484	heat shock protein binding
C3V38_RS03850	COG0443	Heat shock 70 kDa protein
C3V38_RS03855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3V38_RS03865	COG2181	nitrate reductase activity
C3V38_RS03865	COG0247	lactate metabolic process
C3V38_RS03920	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS03935	COG0183	Belongs to the thiolase family
C3V38_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS03945	COG2030	dehydratase
C3V38_RS03950	COG2133	pyrroloquinoline quinone binding
C3V38_RS03955	COG2133	pyrroloquinoline quinone binding
C3V38_RS03980	COG2755	lipolytic protein G-D-S-L family
C3V38_RS03985	COG2755	lipolytic protein G-D-S-L family
C3V38_RS03990	COG2837	iron assimilation
C3V38_RS04020	COG1842	Phage shock protein A
C3V38_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS04060	COG1136	(ABC) transporter
C3V38_RS04060	COG0577	efflux transmembrane transporter activity
C3V38_RS04065	COG1136	(ABC) transporter
C3V38_RS04070	COG0564	pseudouridine synthase activity
C3V38_RS04100	COG1309	transcriptional regulator
C3V38_RS04125	COG1376	ErfK ybiS ycfS ynhG family protein
C3V38_RS04130	COG1376	ErfK ybiS ycfS ynhG family protein
C3V38_RS04145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3V38_RS04150	COG3590	peptidase
C3V38_RS04190	COG2409	Drug exporters of the RND superfamily
C3V38_RS04200	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3V38_RS04220	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C3V38_RS04230	COG2205	protein histidine kinase activity
C3V38_RS04250	COG0438	transferase activity, transferring glycosyl groups
C3V38_RS04285	COG1309	transcriptional regulator
C3V38_RS04290	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS04315	COG2070	2-Nitropropane dioxygenase
C3V38_RS04325	COG1472	Belongs to the glycosyl hydrolase 3 family
C3V38_RS04330	COG0519	Catalyzes the synthesis of GMP from XMP
C3V38_RS04340	COG2860	membrane
C3V38_RS04350	COG0435	Glutathione S-transferase
C3V38_RS04365	COG1917	Cupin 2, conserved barrel domain protein
C3V38_RS04370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C3V38_RS04375	COG0456	acetyltransferase
C3V38_RS04385	COG1403	HNH endonuclease
C3V38_RS04415	COG0483	inositol monophosphate 1-phosphatase activity
C3V38_RS04420	COG1174	glycine betaine transport
C3V38_RS04430	COG1174	glycine betaine transport
C3V38_RS04465	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C3V38_RS04495	COG2409	Drug exporters of the RND superfamily
C3V38_RS04500	COG0596	Alpha beta hydrolase
C3V38_RS04520	COG0463	Glycosyl transferase, family 2
C3V38_RS04525	COG4106	trans-aconitate 2-methyltransferase activity
C3V38_RS04555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3V38_RS04555	COG1648	precorrin-2 dehydrogenase activity
C3V38_RS04560	COG1376	ErfK ybiS ycfS ynhG family protein
C3V38_RS04565	COG3104	oligopeptide transport
C3V38_RS04570	COG1253	flavin adenine dinucleotide binding
C3V38_RS04575	COG1253	flavin adenine dinucleotide binding
C3V38_RS04585	COG0768	penicillin binding
C3V38_RS04595	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS04610	COG1595	DNA-templated transcription, initiation
C3V38_RS04620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3V38_RS04645	COG0710	3-dehydroquinate dehydratase activity
C3V38_RS04665	COG1247	-acetyltransferase
C3V38_RS04685	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3V38_RS04695	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C3V38_RS04705	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C3V38_RS04710	COG0431	NADPH-dependent FMN reductase
C3V38_RS04720	COG2205	protein histidine kinase activity
C3V38_RS04725	COG4585	Histidine kinase
C3V38_RS04730	COG2197	response regulator
C3V38_RS04740	COG4152	abc transporter atp-binding protein
C3V38_RS04750	COG0745	RESPONSE REGULATOR receiver
C3V38_RS04755	COG1045	serine acetyltransferase
C3V38_RS04780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3V38_RS04805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C3V38_RS04830	COG0659	secondary active sulfate transmembrane transporter activity
C3V38_RS04840	COG1027	Aspartate ammonia-lyase
C3V38_RS04845	COG0671	phosphoesterase, PA-phosphatase related
C3V38_RS04850	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C3V38_RS04880	COG0765	amino acid transport
C3V38_RS04885	COG0765	amino acid transport
C3V38_RS04890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3V38_RS04895	COG1126	abc transporter atp-binding protein
C3V38_RS04920	COG0693	protein deglycase activity
C3V38_RS04935	COG0513	Belongs to the DEAD box helicase family
C3V38_RS04950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V38_RS04960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C3V38_RS04960	COG0351	phosphomethylpyrimidine kinase
C3V38_RS04960	COG0352	thiamine-phosphate diphosphorylase activity
C3V38_RS04970	COG0569	domain protein
C3V38_RS04975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3V38_RS04995	COG0477	Major facilitator Superfamily
C3V38_RS05040	COG1192	Involved in chromosome partitioning
C3V38_RS05080	COG2608	mercury ion transmembrane transporter activity
C3V38_RS05085	COG1937	Protein conserved in bacteria
C3V38_RS05110	COG0243	molybdopterin cofactor binding
C3V38_RS05155	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C3V38_RS05230	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS05240	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS05250	COG0405	Gamma-glutamyltransferase
C3V38_RS05255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C3V38_RS05260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V38_RS05265	COG1120	ATPase activity
C3V38_RS05290	COG2409	Drug exporters of the RND superfamily
C3V38_RS05325	COG0297	glycogen (starch) synthase activity
C3V38_RS05365	COG0657	acetylesterase activity
C3V38_RS05375	COG2066	Belongs to the glutaminase family
C3V38_RS05400	COG0662	Cupin 2, conserved barrel domain protein
C3V38_RS05405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3V38_RS05415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3V38_RS05430	COG0386	Belongs to the glutathione peroxidase family
C3V38_RS05445	COG1652	LysM domain
C3V38_RS05460	COG1840	ABC-type Fe3 transport system, periplasmic component
C3V38_RS05470	COG3842	ATPase activity
C3V38_RS05475	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS05480	COG2072	flavoprotein involved in K transport
C3V38_RS05510	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C3V38_RS05520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3V38_RS05530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3V38_RS05530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3V38_RS05530	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C3V38_RS05535	COG1105	Belongs to the carbohydrate kinase PfkB family
C3V38_RS05540	COG1349	DNA-binding transcription factor activity
C3V38_RS05545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3V38_RS05565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V38_RS05570	COG1120	ATPase activity
C3V38_RS05610	COG1120	ATPase activity
C3V38_RS05615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V38_RS05650	COG1136	(ABC) transporter
C3V38_RS05660	COG4585	Histidine kinase
C3V38_RS05665	COG2197	response regulator
C3V38_RS05680	COG1797	cobyrinic acid a,c-diamide synthase activity
C3V38_RS05695	COG1492	cobalamin metabolic process
C3V38_RS05700	COG0477	Major facilitator Superfamily
C3V38_RS05710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3V38_RS05725	COG0671	phosphoesterase, PA-phosphatase related
C3V38_RS05740	COG0454	-acetyltransferase
C3V38_RS05740	COG0456	acetyltransferase
C3V38_RS05815	COG0305	Participates in initiation and elongation during chromosome replication
C3V38_RS05820	COG0359	binds to the 23S rRNA
C3V38_RS05825	COG0629	single-stranded DNA binding
C3V38_RS05840	COG4249	Peptidase C14 caspase catalytic subunit p20
C3V38_RS05840	COG2319	Wd-40 repeat
C3V38_RS05855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3V38_RS05870	COG1260	myo-inositol-1-phosphate synthase
C3V38_RS05880	COG2264	protein methyltransferase activity
C3V38_RS05905	COG3383	formate dehydrogenase (NAD+) activity
C3V38_RS05905	COG0243	molybdopterin cofactor binding
C3V38_RS05910	COG0437	4 iron, 4 sulfur cluster binding
C3V38_RS05925	COG1921	L-seryl-tRNASec selenium transferase activity
C3V38_RS05935	COG0709	Synthesizes selenophosphate from selenide and ATP
C3V38_RS05940	COG1473	amidohydrolase
C3V38_RS05940	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C3V38_RS05950	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C3V38_RS05950	COG2308	Evidence 4 Homologs of previously reported genes of
C3V38_RS05955	COG2308	Evidence 4 Homologs of previously reported genes of
C3V38_RS05955	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C3V38_RS05960	COG1024	Enoyl-CoA hydratase
C3V38_RS05965	COG1802	Transcriptional regulator
C3V38_RS05975	COG1024	Enoyl-CoA hydratase
C3V38_RS05990	COG1012	belongs to the aldehyde dehydrogenase family
C3V38_RS05995	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS06030	COG3842	ATPase activity
C3V38_RS06050	COG4221	oxidoreductase activity
C3V38_RS06055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C3V38_RS06105	COG3321	synthase
C3V38_RS06105	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS06105	COG0604	alcohol dehydrogenase
C3V38_RS06110	COG2130	NADP-dependent
C3V38_RS06125	COG3631	Ketosteroid isomerase-related protein
C3V38_RS06130	COG0477	Major facilitator Superfamily
C3V38_RS06145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3V38_RS06150	COG0640	Transcriptional regulator
C3V38_RS06160	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS06170	COG2267	carboxylic ester hydrolase activity
C3V38_RS06200	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS06210	COG0495	leucyl-tRNA aminoacylation
C3V38_RS06215	COG2259	Doxx family
C3V38_RS06240	COG2149	membrane
C3V38_RS06275	COG2124	cytochrome p450
C3V38_RS06285	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C3V38_RS06295	COG2271	Major facilitator Superfamily
C3V38_RS06300	COG1678	Uncharacterized ACR, COG1678
C3V38_RS06315	COG5650	phosphatidylinositol metabolic process
C3V38_RS06320	COG0617	tRNA 3'-terminal CCA addition
C3V38_RS06320	COG1353	crispr-associated protein
C3V38_RS06360	COG1595	DNA-templated transcription, initiation
C3V38_RS06375	COG3409	Peptidoglycan-binding domain 1 protein
C3V38_RS06375	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3V38_RS06390	COG1192	Involved in chromosome partitioning
C3V38_RS06395	COG0357	Ribosomal RNA small subunit methyltransferase G
C3V38_RS06410	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3V38_RS06415	COG0594	ribonuclease P activity
C3V38_RS06420	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C3V38_RS06425	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3V38_RS06430	COG0592	DNA-directed DNA polymerase activity
C3V38_RS06435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3V38_RS06440	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C3V38_RS06445	COG0187	DNA topoisomerase II activity
C3V38_RS06475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3V38_RS06555	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3V38_RS06560	COG1132	(ABC) transporter
C3V38_RS06565	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS06570	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
C3V38_RS06585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3V38_RS06590	COG0705	Rhomboid family
C3V38_RS06590	COG0457	Tetratricopeptide repeat
C3V38_RS06610	COG2815	serine threonine protein kinase
C3V38_RS06610	COG0515	serine threonine protein kinase
C3V38_RS06615	COG0515	serine threonine protein kinase
C3V38_RS06620	COG0768	penicillin binding
C3V38_RS06640	COG1716	ATPase activity
C3V38_RS06655	COG4584	PFAM Integrase catalytic
C3V38_RS06660	COG1484	DNA-dependent DNA replication
C3V38_RS06695	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C3V38_RS06700	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C3V38_RS06710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V38_RS06715	COG3387	PFAM Glycoside hydrolase 15-related
C3V38_RS06720	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS06730	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS06750	COG3415	Transposase
C3V38_RS06750	COG2801	Transposase and inactivated derivatives
C3V38_RS06755	COG0596	Alpha beta hydrolase
C3V38_RS06795	COG2353	YceI-like domain
C3V38_RS06810	COG2072	flavoprotein involved in K transport
C3V38_RS06850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3V38_RS06850	COG2169	Transcriptional regulator
C3V38_RS06855	COG1280	lysine exporter protein (LysE YggA)
C3V38_RS06865	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C3V38_RS06915	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS06920	COG2365	Tyrosine phosphatase family
C3V38_RS06935	COG1074	ATP-dependent DNA helicase activity
C3V38_RS07020	COG1064	alcohol dehydrogenase
C3V38_RS07040	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C3V38_RS07055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C3V38_RS07070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C3V38_RS07075	COG1115	amino acid carrier protein
C3V38_RS07085	COG1403	HNH endonuclease
C3V38_RS07090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3V38_RS07095	COG0175	sulfate reduction
C3V38_RS07100	COG1648	precorrin-2 dehydrogenase activity
C3V38_RS07100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3V38_RS07140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3V38_RS07145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3V38_RS07165	COG1403	HNH endonuclease
C3V38_RS07175	COG0315	cyclic pyranopterin monophosphate synthase activity
C3V38_RS07175	COG0521	Mo-molybdopterin cofactor biosynthetic process
C3V38_RS07180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3V38_RS07185	COG1902	pentaerythritol trinitrate reductase activity
C3V38_RS07205	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C3V38_RS07210	COG0028	Belongs to the TPP enzyme family
C3V38_RS07230	COG2233	PERMEase
C3V38_RS07235	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C3V38_RS07255	COG2514	catechol 2,3-dioxygenase activity
C3V38_RS07280	COG0477	Major facilitator Superfamily
C3V38_RS07285	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C3V38_RS07300	COG1484	DNA-dependent DNA replication
C3V38_RS07305	COG4584	PFAM Integrase catalytic
C3V38_RS07315	COG1045	serine acetyltransferase
C3V38_RS07330	COG1022	Amp-dependent synthetase and ligase
C3V38_RS07355	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C3V38_RS07355	COG0069	glutamate synthase activity
C3V38_RS07360	COG1929	Belongs to the glycerate kinase type-1 family
C3V38_RS07385	COG0069	glutamate synthase activity
C3V38_RS07385	COG0070	glutamate synthase
C3V38_RS07385	COG0067	glutamate synthase
C3V38_RS07410	COG2501	S4 domain
C3V38_RS07425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C3V38_RS07430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3V38_RS07435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3V38_RS07450	COG0789	Transcriptional regulator
C3V38_RS07455	COG1012	belongs to the aldehyde dehydrogenase family
C3V38_RS07490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C3V38_RS07495	COG1051	belongs to the nudix hydrolase family
C3V38_RS07505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3V38_RS07510	COG1278	Cold shock
C3V38_RS07515	COG3189	MarR family transcriptional regulator
C3V38_RS07540	COG1316	TRANSCRIPTIONal
C3V38_RS07560	COG0077	Prephenate dehydratase
C3V38_RS07585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3V38_RS07600	COG0561	phosphatase activity
C3V38_RS07625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3V38_RS07635	COG1216	Glycosyl transferase, family 2
C3V38_RS07640	COG0671	phosphoesterase, PA-phosphatase related
C3V38_RS07645	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C3V38_RS07650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C3V38_RS07670	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
C3V38_RS07680	COG3321	synthase
C3V38_RS07680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3V38_RS07680	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C3V38_RS07685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3V38_RS07710	COG0277	FAD linked oxidase domain protein
C3V38_RS07740	COG1216	Glycosyl transferase, family 2
C3V38_RS07780	COG1216	Glycosyl transferase, family 2
C3V38_RS07795	COG2130	NADP-dependent
C3V38_RS07805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3V38_RS07810	COG0569	domain protein
C3V38_RS07825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V38_RS07830	COG0604	alcohol dehydrogenase
C3V38_RS07845	COG0737	Belongs to the 5'-nucleotidase family
C3V38_RS07850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3V38_RS07980	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C3V38_RS07995	COG1403	HNH endonuclease
C3V38_RS08005	COG0697	spore germination
C3V38_RS08045	COG0287	Prephenate dehydrogenase
C3V38_RS08070	COG1309	transcriptional regulator
C3V38_RS08075	COG0343	queuine tRNA-ribosyltransferase activity
C3V38_RS08090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3V38_RS08110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3V38_RS08120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C3V38_RS08125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3V38_RS08135	COG1492	cobalamin metabolic process
C3V38_RS08150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C3V38_RS08160	COG1950	PFAM Membrane protein of
C3V38_RS08170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3V38_RS08185	COG0697	spore germination
C3V38_RS08205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C3V38_RS08225	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3V38_RS08235	COG2850	peptidyl-arginine hydroxylation
C3V38_RS08250	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C3V38_RS08300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V38_RS08305	COG2860	membrane
C3V38_RS08310	COG0174	glutamine synthetase
C3V38_RS08315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3V38_RS08320	COG0798	PFAM Bile acid sodium symporter
C3V38_RS08330	COG2184	nucleotidyltransferase activity
C3V38_RS08340	COG0671	phosphoesterase, PA-phosphatase related
C3V38_RS08350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C3V38_RS08355	COG0156	8-amino-7-oxononanoate synthase activity
C3V38_RS08360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3V38_RS08365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3V38_RS08390	COG0477	Major facilitator Superfamily
C3V38_RS08400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3V38_RS08405	COG3764	Sortase (surface protein transpeptidase)
C3V38_RS08415	COG0589	response to stress
C3V38_RS08430	COG0783	Belongs to the Dps family
C3V38_RS08440	COG0651	ATP synthesis coupled electron transport
C3V38_RS08445	COG0651	ATP synthesis coupled electron transport
C3V38_RS08450	COG0651	ATP synthesis coupled electron transport
C3V38_RS08465	COG1320	monovalent cation:proton antiporter activity
C3V38_RS08475	COG2239	Acts as a magnesium transporter
C3V38_RS08495	COG0651	ATP synthesis coupled electron transport
C3V38_RS08500	COG1006	Multisubunit Na H antiporter MnhC subunit
C3V38_RS08505	COG2111	Na H antiporter
C3V38_RS08505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3V38_RS08530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C3V38_RS08560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3V38_RS08580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3V38_RS08605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3V38_RS08655	COG1111	helicase
C3V38_RS08655	COG1205	dead DEAH box helicase
C3V38_RS08675	COG1013	pyruvate-flavodoxin oxidoreductase activity
C3V38_RS08680	COG0674	pyruvate-flavodoxin oxidoreductase activity
C3V38_RS08680	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C3V38_RS08685	COG1754	DNA topoisomerase type I activity
C3V38_RS08685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3V38_RS08695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C3V38_RS08705	COG1024	Enoyl-CoA hydratase
C3V38_RS08715	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS08750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3V38_RS08860	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C3V38_RS08865	COG2027	D-alanyl-D-alanine carboxypeptidase
C3V38_RS08870	COG0037	tRNA processing
C3V38_RS08875	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C3V38_RS08885	COG1595	DNA-templated transcription, initiation
C3V38_RS08890	COG0154	amidase activity
C3V38_RS08895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3V38_RS08900	COG0302	gtp cyclohydrolase
C3V38_RS08910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C3V38_RS08935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C3V38_RS08940	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C3V38_RS08945	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C3V38_RS08950	COG3384	dioxygenase
C3V38_RS08960	COG2066	Belongs to the glutaminase family
C3V38_RS08965	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C3V38_RS08975	COG1643	Atp-dependent helicase
C3V38_RS09005	COG0288	reversible hydration of carbon dioxide
C3V38_RS09015	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C3V38_RS09020	COG2847	Copper chaperone PCu(A)C
C3V38_RS09030	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C3V38_RS09035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3V38_RS09055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3V38_RS09060	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C3V38_RS09065	COG0803	Belongs to the bacterial solute-binding protein 9 family
C3V38_RS09070	COG1877	trehalose-phosphatase activity
C3V38_RS09075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3V38_RS09080	COG0765	amino acid transport
C3V38_RS09085	COG0765	amino acid transport
C3V38_RS09090	COG1126	abc transporter atp-binding protein
C3V38_RS09095	COG0154	amidase activity
C3V38_RS09100	COG1802	Transcriptional regulator
C3V38_RS09115	COG0277	FAD linked oxidase domain protein
C3V38_RS09115	COG0247	lactate metabolic process
C3V38_RS09120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C3V38_RS09125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3V38_RS09130	COG5285	phytanoyl-CoA dioxygenase
C3V38_RS09135	COG0583	DNA-binding transcription factor activity
C3V38_RS09140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3V38_RS09145	COG1309	transcriptional regulator
C3V38_RS09150	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS09155	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS09160	COG2030	dehydratase
C3V38_RS09170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3V38_RS09190	COG0366	Alpha amylase catalytic
C3V38_RS09205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V38_RS09210	COG2030	dehydratase
C3V38_RS09215	COG1053	succinate dehydrogenase
C3V38_RS09220	COG3971	2-oxopent-4-enoate hydratase activity
C3V38_RS09225	COG1414	Transcriptional regulator
C3V38_RS09230	COG1403	HNH endonuclease
C3V38_RS09235	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C3V38_RS09240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3V38_RS09250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3V38_RS09260	COG4638	Rieske (2fe-2S)
C3V38_RS09265	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS09270	COG0346	lactoylglutathione lyase activity
C3V38_RS09275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3V38_RS09290	COG1218	3'(2'),5'-bisphosphate nucleotidase
C3V38_RS09295	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS09300	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS09305	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS09310	COG1024	Enoyl-CoA hydratase
C3V38_RS09320	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS09325	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS09330	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS09335	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS09340	COG1309	transcriptional regulator
C3V38_RS09345	COG0183	Belongs to the thiolase family
C3V38_RS09375	COG1024	Enoyl-CoA hydratase
C3V38_RS09380	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS09385	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS09405	COG0183	Belongs to the thiolase family
C3V38_RS09410	COG2124	cytochrome p450
C3V38_RS09440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V38_RS09450	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS09455	COG1012	belongs to the aldehyde dehydrogenase family
C3V38_RS09460	COG0784	Response regulator, receiver
C3V38_RS09460	COG2205	protein histidine kinase activity
C3V38_RS09460	COG5002	protein histidine kinase activity
C3V38_RS09475	COG1024	Enoyl-CoA hydratase
C3V38_RS09485	COG3415	Transposase
C3V38_RS09485	COG2801	Transposase and inactivated derivatives
C3V38_RS09495	COG2070	2-Nitropropane dioxygenase
C3V38_RS09505	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS09510	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS09515	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS09530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C3V38_RS09535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C3V38_RS09560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C3V38_RS09580	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C3V38_RS09610	COG0537	adenosine 5'-monophosphoramidase activity
C3V38_RS09625	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C3V38_RS09630	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS09635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3V38_RS09645	COG0471	metal ion transport
C3V38_RS09655	COG0436	Aminotransferase
C3V38_RS09665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C3V38_RS09675	COG2267	carboxylic ester hydrolase activity
C3V38_RS09680	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3V38_RS09700	COG0386	Belongs to the glutathione peroxidase family
C3V38_RS09710	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3V38_RS09715	COG0047	phosphoribosylformylglycinamidine synthase activity
C3V38_RS09725	COG3268	Saccharopine dehydrogenase
C3V38_RS09755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3V38_RS09775	COG4044	May play a role in the intracellular transport of hydrophobic ligands
C3V38_RS09795	COG0745	RESPONSE REGULATOR receiver
C3V38_RS09800	COG0456	acetyltransferase
C3V38_RS09800	COG0454	-acetyltransferase
C3V38_RS09820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3V38_RS09870	COG2197	response regulator
C3V38_RS09880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3V38_RS09915	COG2132	Multicopper oxidase
C3V38_RS09920	COG0745	RESPONSE REGULATOR receiver
C3V38_RS09925	COG2205	protein histidine kinase activity
C3V38_RS09950	COG0183	Belongs to the thiolase family
C3V38_RS09955	COG1024	Enoyl-CoA hydratase
C3V38_RS09955	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3V38_RS09965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3V38_RS09975	COG2223	nitrite transmembrane transporter activity
C3V38_RS09980	COG0243	molybdopterin cofactor binding
C3V38_RS09985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3V38_RS09995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3V38_RS09995	COG2146	nitrite reductase [NAD(P)H] activity
C3V38_RS10000	COG2146	nitrite reductase [NAD(P)H] activity
C3V38_RS10000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3V38_RS10010	COG1061	Type III restriction enzyme res subunit
C3V38_RS10025	COG1652	LysM domain
C3V38_RS10035	COG1278	Cold shock
C3V38_RS10045	COG2814	Major facilitator Superfamily
C3V38_RS10065	COG2252	PERMEase
C3V38_RS10070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3V38_RS10100	COG0545	Peptidyl-prolyl cis-trans isomerase
C3V38_RS10115	COG1024	Enoyl-CoA hydratase
C3V38_RS10130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3V38_RS10155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3V38_RS10165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3V38_RS10175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3V38_RS10190	COG1214	PFAM Peptidase M22, glycoprotease
C3V38_RS10190	COG0456	acetyltransferase
C3V38_RS10195	COG0456	acetyltransferase
C3V38_RS10200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C3V38_RS10215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3V38_RS10220	COG0459	protein refolding
C3V38_RS10260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3V38_RS10260	COG0519	Catalyzes the synthesis of GMP from XMP
C3V38_RS10320	COG0587	DNA-directed DNA polymerase activity
C3V38_RS10330	COG0277	FAD linked oxidase domain protein
C3V38_RS10340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3V38_RS10345	COG1121	(ABC) transporter
C3V38_RS10350	COG0803	Belongs to the bacterial solute-binding protein 9 family
C3V38_RS10355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C3V38_RS10360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3V38_RS10380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3V38_RS10385	COG2873	o-acetylhomoserine
C3V38_RS10395	COG0385	Bile acid
C3V38_RS10400	COG2814	Major facilitator Superfamily
C3V38_RS10425	COG0180	Tryptophanyl-tRNA synthetase
C3V38_RS10430	COG0328	RNA-DNA hybrid ribonuclease activity
C3V38_RS10455	COG1686	Belongs to the peptidase S11 family
C3V38_RS10460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C3V38_RS10475	COG2009	succinate dehydrogenase
C3V38_RS10505	COG0791	NLP P60 protein
C3V38_RS10525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3V38_RS10545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3V38_RS10550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3V38_RS10555	COG4770	biotin carboxylase activity
C3V38_RS10575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3V38_RS10580	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C3V38_RS10580	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C3V38_RS10610	COG1316	TRANSCRIPTIONal
C3V38_RS10620	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C3V38_RS10625	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C3V38_RS10625	COG0778	Nitroreductase
C3V38_RS10630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C3V38_RS10650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3V38_RS10660	COG1482	cell wall glycoprotein biosynthetic process
C3V38_RS10685	COG0745	RESPONSE REGULATOR receiver
C3V38_RS10690	COG5002	protein histidine kinase activity
C3V38_RS10695	COG5401	PFAM Sporulation and spore germination
C3V38_RS10705	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C3V38_RS10710	COG0653	protein targeting
C3V38_RS10720	COG1011	Hydrolase
C3V38_RS10740	COG1162	GTPase activity
C3V38_RS10745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3V38_RS10760	COG1595	DNA-templated transcription, initiation
C3V38_RS10770	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C3V38_RS10790	COG0513	Belongs to the DEAD box helicase family
C3V38_RS10835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3V38_RS10855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C3V38_RS10875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3V38_RS10880	COG1615	UPF0182 protein
C3V38_RS10895	COG2072	flavoprotein involved in K transport
C3V38_RS10900	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS10905	COG1309	transcriptional regulator
C3V38_RS10915	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS10920	COG1960	acyl-CoA dehydrogenase activity
C3V38_RS10925	COG0483	inositol monophosphate 1-phosphatase activity
C3V38_RS10930	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C3V38_RS10935	COG0668	transmembrane transport
C3V38_RS10940	COG2884	Cell division ATP-binding protein ftsE
C3V38_RS10945	COG2177	Part of the ABC transporter FtsEX involved in
C3V38_RS11005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3V38_RS11020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3V38_RS11045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C3V38_RS11065	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C3V38_RS11070	COG1234	tRNA 3'-trailer cleavage
C3V38_RS11075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C3V38_RS11080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C3V38_RS11100	COG2340	Cysteine-rich secretory protein family
C3V38_RS11110	COG3265	gluconokinase activity
C3V38_RS11120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C3V38_RS11130	COG0733	neurotransmitter:sodium symporter activity
C3V38_RS11140	COG2030	dehydratase
C3V38_RS11145	COG0736	holo-[acyl-carrier-protein] synthase activity
C3V38_RS11170	COG1376	ErfK ybiS ycfS ynhG family protein
C3V38_RS11190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C3V38_RS11195	COG4221	oxidoreductase activity
C3V38_RS11210	COG0546	phosphoglycolate phosphatase activity
C3V38_RS11215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V38_RS11280	COG0366	Alpha amylase catalytic
C3V38_RS11300	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C3V38_RS11325	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3V38_RS11330	COG0740	serine-type endopeptidase activity
C3V38_RS11335	COG0740	serine-type endopeptidase activity
C3V38_RS11340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C3V38_RS11350	COG4829	muconolactone delta-isomerase
C3V38_RS11370	COG0039	L-malate dehydrogenase activity
C3V38_RS11375	COG0525	valine-tRNA ligase activity
C3V38_RS11380	COG0285	dihydrofolate synthase activity
C3V38_RS11390	COG0105	UTP biosynthetic process
C3V38_RS11395	COG1530	ribonuclease E activity
C3V38_RS11405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C3V38_RS11410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3V38_RS11415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3V38_RS11420	COG0288	reversible hydration of carbon dioxide
C3V38_RS11440	COG3573	Dehydrogenase
C3V38_RS11445	COG0530	calcium, potassium:sodium antiporter activity
C3V38_RS11450	COG0514	ATP-dependent DNA helicase (RecQ)
C3V38_RS11455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C3V38_RS11460	COG4106	trans-aconitate 2-methyltransferase activity
C3V38_RS11465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C3V38_RS11470	COG0542	response to heat
C3V38_RS11480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3V38_RS11495	COG1307	EDD domain protein, DegV family
C3V38_RS11500	COG1555	photosystem II stabilization
C3V38_RS11510	COG0514	ATP-dependent DNA helicase (RecQ)
C3V38_RS11515	COG2080	2 iron, 2 sulfur cluster binding
C3V38_RS11520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C3V38_RS11525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3V38_RS11540	COG4221	oxidoreductase activity
C3V38_RS11545	COG1028	Short-chain dehydrogenase reductase Sdr
C3V38_RS11555	COG0268	Binds directly to 16S ribosomal RNA
C3V38_RS11570	COG0481	GTPase activity
C3V38_RS11585	COG0339	signal peptide processing
C3V38_RS11605	COG1420	regulation of RNA biosynthetic process
C3V38_RS11610	COG0484	heat shock protein binding
C3V38_RS11640	COG1381	Involved in DNA repair and RecF pathway recombination
C3V38_RS11645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3V38_RS11660	COG0423	glycine-tRNA ligase activity
C3V38_RS11685	COG0358	DNA primase activity
C3V38_RS11720	COG0657	acetylesterase activity
C3V38_RS11725	COG1131	(ABC) transporter
C3V38_RS11750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3V38_RS11755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C3V38_RS11765	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C3V38_RS11810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C3V38_RS11810	COG3323	Protein of unknown function (DUF1653)
C3V38_RS11835	COG2072	flavoprotein involved in K transport
C3V38_RS11850	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C3V38_RS11855	COG0174	glutamine synthetase
C3V38_RS11860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C3V38_RS11890	COG0174	glutamine synthetase
C3V38_RS11905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3V38_RS11910	COG0321	lipoyl(octanoyl) transferase activity
C3V38_RS11915	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3V38_RS11930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3V38_RS11935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3V38_RS11945	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C3V38_RS11960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3V38_RS11970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C3V38_RS11995	COG1053	succinate dehydrogenase
C3V38_RS12000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3V38_RS12005	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C3V38_RS12020	COG1845	cytochrome c oxidase, subunit III
C3V38_RS12025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3V38_RS12050	COG0438	transferase activity, transferring glycosyl groups
C3V38_RS12055	COG1022	Amp-dependent synthetase and ligase
C3V38_RS12080	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C3V38_RS12100	COG0142	geranyltranstransferase activity
C3V38_RS12155	COG0768	penicillin binding
C3V38_RS12175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3V38_RS12185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3V38_RS12190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3V38_RS12195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C3V38_RS12200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3V38_RS12210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C3V38_RS12225	COG3599	regulation of cell shape
C3V38_RS12235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3V38_RS12245	COG0252	asparaginase activity
C3V38_RS12260	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3V38_RS12295	COG1739	Uncharacterized protein family UPF0029
C3V38_RS12375	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C3V38_RS12430	COG2315	Protein conserved in bacteria
C3V38_RS12440	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C3V38_RS12445	COG0076	glutamate decarboxylase activity
C3V38_RS12450	COG4607	ABC-type enterochelin transport system periplasmic component
C3V38_RS12455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V38_RS12460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V38_RS12465	COG1120	ATPase activity
C3V38_RS12505	COG1122	ATPase activity
C3V38_RS12510	COG1268	BioY protein
C3V38_RS12545	COG3447	MASE1 domain protein
C3V38_RS12545	COG5001	Diguanylate cyclase
C3V38_RS12545	COG5002	protein histidine kinase activity
C3V38_RS12555	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3V38_RS12565	COG0131	Imidazoleglycerol-phosphate dehydratase
C3V38_RS12575	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C3V38_RS12585	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C3V38_RS12590	COG0483	inositol monophosphate 1-phosphatase activity
C3V38_RS12595	COG0107	imidazoleglycerol-phosphate synthase activity
C3V38_RS12610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C3V38_RS12635	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C3V38_RS12640	COG0469	pyruvate kinase activity
C3V38_RS12745	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C3V38_RS12765	COG0765	amino acid transport
C3V38_RS12770	COG1126	abc transporter atp-binding protein
C3V38_RS12780	COG0539	negative regulation of cytoplasmic translation
C3V38_RS12785	COG0237	dephospho-CoA kinase activity
C3V38_RS12785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C3V38_RS12815	COG3973	AAA domain
C3V38_RS12845	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C3V38_RS12855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3V38_RS12860	COG0488	(ABC) transporter
C3V38_RS12865	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3V38_RS12870	COG0072	phenylalanine-tRNA ligase activity
C3V38_RS12870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3V38_RS12875	COG0351	phosphomethylpyrimidine kinase
C3V38_RS12875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C3V38_RS12875	COG0352	thiamine-phosphate diphosphorylase activity
C3V38_RS12895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3V38_RS12900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3V38_RS12910	COG1438	arginine binding
C3V38_RS12920	COG0165	Argininosuccinate lyase
C3V38_RS12930	COG2094	Belongs to the DNA glycosylase MPG family
C3V38_RS12935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3V38_RS12960	COG0647	UMP catabolic process
C3V38_RS13010	COG0494	nUDIX hydrolase
C3V38_RS13025	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C3V38_RS13030	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3V38_RS13040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C3V38_RS13045	COG1160	GTP binding
C3V38_RS13090	COG0653	protein targeting
C3V38_RS13105	COG1716	ATPase activity
C3V38_RS13125	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3V38_RS13125	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3V38_RS13135	COG0596	Alpha beta hydrolase
C3V38_RS13140	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS13150	COG3012	SEC-C Motif Domain Protein
C3V38_RS13170	COG1309	transcriptional regulator
C3V38_RS13180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C3V38_RS13215	COG0123	including yeast histone deacetylase and acetoin utilization protein
C3V38_RS13220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3V38_RS13220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3V38_RS13230	COG1490	D-aminoacyl-tRNA deacylase activity
C3V38_RS13315	COG0450	alkyl hydroperoxide reductase
C3V38_RS13330	COG0513	Belongs to the DEAD box helicase family
C3V38_RS13335	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C3V38_RS13350	COG1252	NADH dehydrogenase
C3V38_RS13355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3V38_RS13395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3V38_RS13465	COG0789	Transcriptional regulator
C3V38_RS13520	COG2963	transposase activity
C3V38_RS13535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V38_RS13545	COG1120	ATPase activity
C3V38_RS13550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V38_RS13575	COG1846	Transcriptional regulator
C3V38_RS13585	COG0488	(ABC) transporter
C3V38_RS13610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3V38_RS13655	COG0300	oxidoreductase activity
C3V38_RS13670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3V38_RS13685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3V38_RS13700	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C3V38_RS13715	COG1222	aaa ATPase
C3V38_RS13735	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3V38_RS13740	COG0140	phosphoribosyl-ATP diphosphatase activity
C3V38_RS13750	COG0646	methionine synthase
C3V38_RS13750	COG1410	methionine synthase
C3V38_RS13760	COG0215	cysteine-tRNA ligase activity
C3V38_RS13780	COG1968	undecaprenyl-diphosphatase activity
C3V38_RS13865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C3V38_RS13870	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C3V38_RS13880	COG2304	oxidoreductase activity
C3V38_RS13890	COG0714	Associated with various cellular activities
C3V38_RS13895	COG0791	NLP P60 protein
C3V38_RS13895	COG3883	PFAM NLP P60 protein
C3V38_RS13905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C3V38_RS13910	COG1309	transcriptional regulator
C3V38_RS13935	COG0589	response to stress
C3V38_RS13965	COG1201	RNA secondary structure unwinding
C3V38_RS13975	COG0488	(ABC) transporter
C3V38_RS13995	COG2151	metal-sulfur cluster biosynthetic enzyme
C3V38_RS14010	COG0396	ATPase activity
C3V38_RS14035	COG1131	(ABC) transporter
C3V38_RS14060	COG0109	protoheme IX farnesyltransferase activity
C3V38_RS14065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C3V38_RS14090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3V38_RS14095	COG0149	triose-phosphate isomerase activity
C3V38_RS14100	COG0126	phosphoglycerate kinase activity
C3V38_RS14105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3V38_RS14110	COG1481	regulation of sporulation
C3V38_RS14120	COG1660	Displays ATPase and GTPase activities
C3V38_RS14125	COG0322	excinuclease ABC activity
C3V38_RS14135	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C3V38_RS14140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3V38_RS14140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3V38_RS14175	COG0242	peptide deformylase activity
C3V38_RS14185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C3V38_RS14200	COG0194	GDP metabolic process
C3V38_RS14215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3V38_RS14240	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C3V38_RS14250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3V38_RS14255	COG0006	proline dipeptidase activity
C3V38_RS14260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3V38_RS14265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C3V38_RS14270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C3V38_RS14275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3V38_RS14280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C3V38_RS14290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C3V38_RS14305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3V38_RS14315	COG0124	histidyl-tRNA synthetase
C3V38_RS14320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3V38_RS14325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3V38_RS14330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3V38_RS14340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3V38_RS14355	COG2255	four-way junction helicase activity
C3V38_RS14360	COG0632	four-way junction helicase activity
C3V38_RS14365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C3V38_RS14375	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C3V38_RS14380	COG1946	Acyl-CoA thioesterase
C3V38_RS14385	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C3V38_RS14405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C3V38_RS14415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3V38_RS14420	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C3V38_RS14535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3V38_RS14545	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C3V38_RS14550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C3V38_RS14565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C3V38_RS14570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3V38_RS14575	COG0531	amino acid
C3V38_RS14580	COG0569	domain protein
C3V38_RS14600	COG1643	Atp-dependent helicase
C3V38_RS14605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3V38_RS14620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3V38_RS14625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C3V38_RS14630	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C3V38_RS14635	COG1414	Transcriptional regulator
C3V38_RS14640	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3V38_RS14650	COG1196	nuclear chromosome segregation
C3V38_RS14660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3V38_RS14670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C3V38_RS14680	COG1842	Phage shock protein A
C3V38_RS14685	COG1396	sequence-specific DNA binding
C3V38_RS14690	COG1546	Belongs to the CinA family
C3V38_RS14690	COG1058	Belongs to the CinA family
C3V38_RS14710	COG1674	ftsk spoiiie
C3V38_RS14720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C3V38_RS14725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3V38_RS14745	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3V38_RS14760	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C3V38_RS14770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3V38_RS14780	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C3V38_RS14790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C3V38_RS14795	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3V38_RS14800	COG0481	GTPase activity
C3V38_RS14800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3V38_RS14830	COG0442	prolyl-tRNA aminoacylation
C3V38_RS14835	COG3022	response to hydroperoxide
C3V38_RS14905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3V38_RS14905	COG1648	precorrin-2 dehydrogenase activity
C3V38_RS14910	COG0579	oxidoreductase
C3V38_RS14925	COG2072	flavoprotein involved in K transport
C3V38_RS14950	COG0750	zinc metalloprotease
C3V38_RS14955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C3V38_RS14980	COG0233	cytoplasmic translational termination
C3V38_RS14990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3V38_RS14995	COG0052	Belongs to the universal ribosomal protein uS2 family
C3V38_RS15020	COG0792	nuclease activity
C3V38_RS15030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3V38_RS15035	COG0681	Belongs to the peptidase S26 family
C3V38_RS15040	COG0335	large ribosomal subunit rRNA binding
C3V38_RS15045	COG0336	Belongs to the RNA methyltransferase TrmD family
C3V38_RS15050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3V38_RS15070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C3V38_RS15095	COG1196	nuclear chromosome segregation
C3V38_RS15100	COG1254	Belongs to the acylphosphatase family
C3V38_RS15110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3V38_RS15115	COG0571	ribonuclease III activity
C3V38_RS15135	COG0742	ribosomal rna small subunit methyltransferase
C3V38_RS15140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C3V38_RS15145	COG1461	Dihydroxyacetone kinase
C3V38_RS15150	COG1024	Enoyl-CoA hydratase
C3V38_RS15155	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3V38_RS15160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C3V38_RS15175	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3V38_RS15180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3V38_RS15185	COG1920	GTP binding
C3V38_RS15190	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C3V38_RS15195	COG0494	nUDIX hydrolase
C3V38_RS15195	COG0406	alpha-ribazole phosphatase activity
C3V38_RS15205	COG0066	3-isopropylmalate dehydratase activity
C3V38_RS15210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3V38_RS15230	COG1309	transcriptional regulator
C3V38_RS15255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3V38_RS15265	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3V38_RS15270	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C3V38_RS15280	COG0473	3-isopropylmalate dehydrogenase activity
C3V38_RS15295	COG0644	oxidoreductase
C3V38_RS15305	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C3V38_RS15310	COG0440	acetolactate synthase activity
C3V38_RS15330	COG0129	dihydroxy-acid dehydratase activity
C3V38_RS15345	COG1403	HNH endonuclease
C3V38_RS15355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3V38_RS15360	COG0205	6-phosphofructokinase activity
C3V38_RS15375	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3V38_RS15385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3V38_RS15400	COG0482	sulfurtransferase activity
C3V38_RS15410	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3V38_RS15420	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS15440	COG1119	ATPase activity
C3V38_RS15445	COG0366	Alpha amylase catalytic
C3V38_RS15450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C3V38_RS15460	COG0183	Belongs to the thiolase family
C3V38_RS15480	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C3V38_RS15500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3V38_RS15505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3V38_RS15510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3V38_RS15515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3V38_RS15520	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3V38_RS15525	COG0356	it plays a direct role in the translocation of protons across the membrane
C3V38_RS15545	COG2890	protein-(glutamine-N5) methyltransferase activity
C3V38_RS15550	COG3415	Transposase
C3V38_RS15550	COG2801	Transposase and inactivated derivatives
C3V38_RS15555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3V38_RS15565	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS15575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C3V38_RS15580	COG0460	homoserine dehydrogenase
C3V38_RS15620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3V38_RS15635	COG0477	Major facilitator Superfamily
C3V38_RS15640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3V38_RS15665	COG0567	Dehydrogenase, E1 component
C3V38_RS15665	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3V38_RS15715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3V38_RS15720	COG5662	AntiSigma factor
C3V38_RS15735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C3V38_RS15740	COG0297	glycogen (starch) synthase activity
C3V38_RS15745	COG2226	methyltransferase
C3V38_RS15750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C3V38_RS15765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C3V38_RS15770	COG1611	Belongs to the LOG family
C3V38_RS15780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3V38_RS15800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C3V38_RS15820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3V38_RS15825	COG0747	negative chemotaxis
C3V38_RS15830	COG1217	gtp-binding protein TYPA
C3V38_RS15875	COG0427	acetyl-CoA hydrolase
C3V38_RS15880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3V38_RS15915	COG2135	peptidase activity
C3V38_RS16010	COG1192	Involved in chromosome partitioning
C3V38_RS16055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C3V38_RS16390	COG0601	transmembrane transport
C3V38_RS16415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3V38_RS16420	COG1124	(ABC) transporter
C3V38_RS16425	COG1002	Type II restriction enzyme, methylase subunits
C3V38_RS16550	COG0557	exoribonuclease II activity
C3V38_RS16625	COG0714	Associated with various cellular activities
C3V38_RS16655	COG1674	ftsk spoiiie
C3V38_RS16690	COG0358	DNA primase activity
C3V38_RS16700	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
C3V38_RS16750	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C3V38_RS16800	COG1674	ftsk spoiiie
C3V38_RS16820	COG0629	single-stranded DNA binding
C3V38_RS16835	COG0305	Participates in initiation and elongation during chromosome replication
C3V38_RS16895	COG2801	Transposase and inactivated derivatives
C3V38_RS16895	COG3415	Transposase
C3V38_RS16900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3V38_RS16940	COG0318	PFAM AMP-dependent synthetase and ligase
C3V38_RS16995	COG1652	LysM domain
C3V38_RS17070	COG0789	Transcriptional regulator
C3V38_RS17090	COG0785	Cytochrome C biogenesis protein
C3V38_RS17100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C3V38_RS17100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C3V38_RS17110	COG2847	Copper chaperone PCu(A)C
C3V38_RS17115	COG2837	iron assimilation
C3V38_RS17145	COG0739	heme binding
C3V38_RS17150	COG3336	cytochrome c oxidase
C3V38_RS17160	COG4942	peptidase
C3V38_RS17185	COG0789	Transcriptional regulator
C3V38_RS17195	COG0477	Major facilitator Superfamily
C3V38_RS17255	COG1192	Involved in chromosome partitioning
C3V38_RS17270	COG3328	transposase activity
C3V38_RS17285	COG0640	Transcriptional regulator