locus-tag	class	description
MED134_RS00025	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MED134_RS00035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MED134_RS00065	COG1073	alpha beta
MED134_RS00075	COG1917	Cupin 2, conserved barrel domain protein
MED134_RS00075	COG2169	Transcriptional regulator
MED134_RS00100	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MED134_RS00105	COG1506	peptidase
MED134_RS00105	COG0823	Involved in the tonB-independent uptake of proteins
MED134_RS00110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MED134_RS00130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MED134_RS00135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MED134_RS00155	COG1595	DNA-templated transcription, initiation
MED134_RS00205	COG0673	inositol 2-dehydrogenase activity
MED134_RS00225	COG0598	Magnesium transport protein CorA
MED134_RS00235	COG0424	maF-like protein
MED134_RS00255	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MED134_RS00255	COG1333	cytochrome c biogenesis protein
MED134_RS00275	COG0612	Peptidase, M16
MED134_RS00295	COG1073	alpha beta
MED134_RS00325	COG1401	restriction endodeoxyribonuclease activity
MED134_RS00325	COG1401	restriction endodeoxyribonuclease activity
MED134_RS00335	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MED134_RS00385	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MED134_RS00450	COG1192	Involved in chromosome partitioning
MED134_RS00530	COG0300	oxidoreductase activity
MED134_RS00545	COG2207	Transcriptional regulator
MED134_RS00560	COG4206	TonB-dependent receptor
MED134_RS00590	COG0784	Response regulator, receiver
MED134_RS00600	COG4251	negative regulation of phosphorylation
MED134_RS00610	COG4251	negative regulation of phosphorylation
MED134_RS00620	COG3279	Response regulator of the LytR AlgR family
MED134_RS00680	COG0463	Glycosyl transferase, family 2
MED134_RS00685	COG1482	cell wall glycoprotein biosynthetic process
MED134_RS00690	COG2095	MarC family integral membrane protein
MED134_RS00700	COG0589	response to stress
MED134_RS00710	COG2217	Heavy metal translocating P-type atpase
MED134_RS00725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MED134_RS00750	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MED134_RS00770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MED134_RS00810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MED134_RS00840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MED134_RS00850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MED134_RS00855	COG0714	Associated with various cellular activities
MED134_RS00875	COG1733	regulation of RNA biosynthetic process
MED134_RS00890	COG3118	belongs to the thioredoxin family
MED134_RS00905	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MED134_RS00930	COG0402	S-adenosylhomocysteine deaminase activity
MED134_RS00935	COG3279	Response regulator of the LytR AlgR family
MED134_RS00945	COG2195	Cleaves the N-terminal amino acid of tripeptides
MED134_RS00950	COG0167	dihydroorotate dehydrogenase activity
MED134_RS00960	COG0366	Alpha amylase catalytic
MED134_RS00970	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MED134_RS00975	COG0540	Belongs to the ATCase OTCase family
MED134_RS00985	COG1234	tRNA 3'-trailer cleavage
MED134_RS00995	COG0259	pyridoxamine-phosphate oxidase activity
MED134_RS01005	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MED134_RS01040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MED134_RS01050	COG0205	6-phosphofructokinase activity
MED134_RS01055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MED134_RS01085	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MED134_RS01130	COG2130	NADP-dependent
MED134_RS01135	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MED134_RS01140	COG1960	acyl-CoA dehydrogenase activity
MED134_RS01145	COG0183	Belongs to the thiolase family
MED134_RS01150	COG1250	3-hydroxyacyl-CoA dehydrogenase
MED134_RS01150	COG1024	Enoyl-CoA hydratase
MED134_RS01190	COG0563	adenylate kinase activity
MED134_RS01205	COG0405	Gamma-glutamyltransferase
MED134_RS01215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MED134_RS01240	COG1187	pseudouridine synthase activity
MED134_RS01245	COG1278	Cold shock
MED134_RS01260	COG0628	permease
MED134_RS01275	COG0612	Peptidase, M16
MED134_RS01285	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MED134_RS01315	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MED134_RS01325	COG0783	Belongs to the Dps family
MED134_RS01330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MED134_RS01335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MED134_RS01340	COG1088	dTDP-glucose 4,6-dehydratase activity
MED134_RS01345	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MED134_RS01355	COG1091	dTDP-4-dehydrorhamnose reductase activity
MED134_RS01370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MED134_RS01375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MED134_RS01380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MED134_RS01395	COG0110	maltose O-acetyltransferase activity
MED134_RS01400	COG0673	inositol 2-dehydrogenase activity
MED134_RS01415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MED134_RS01420	COG0110	maltose O-acetyltransferase activity
MED134_RS01425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MED134_RS01430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MED134_RS01450	COG4464	protein tyrosine phosphatase activity
MED134_RS01460	COG3153	acetyltransferase
MED134_RS01460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MED134_RS01475	COG0010	Belongs to the arginase family
MED134_RS01480	COG1166	arginine decarboxylase activity
MED134_RS01500	COG2207	Transcriptional regulator
MED134_RS01575	COG3590	peptidase
MED134_RS01635	COG2814	Major facilitator Superfamily
MED134_RS01640	COG1012	belongs to the aldehyde dehydrogenase family
MED134_RS01655	COG1061	Type III restriction enzyme res subunit
MED134_RS01670	COG4221	oxidoreductase activity
MED134_RS01690	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MED134_RS01760	COG0579	oxidoreductase
MED134_RS01765	COG1233	COG1233 Phytoene dehydrogenase and related
MED134_RS01785	COG1064	alcohol dehydrogenase
MED134_RS01790	COG1902	pentaerythritol trinitrate reductase activity
MED134_RS01810	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
MED134_RS01820	COG1187	pseudouridine synthase activity
MED134_RS01825	COG1278	Cold shock
MED134_RS01850	COG1132	(ABC) transporter
MED134_RS01860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MED134_RS01885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MED134_RS01885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MED134_RS01890	COG2356	endonuclease I
MED134_RS01920	COG1022	Amp-dependent synthetase and ligase
MED134_RS01930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MED134_RS01935	COG1611	Belongs to the LOG family
MED134_RS01945	COG0022	dehydrogenase e1 component
MED134_RS01950	COG1480	7TM receptor with intracellular HD hydrolase
MED134_RS01955	COG0183	Belongs to the thiolase family
MED134_RS01960	COG0791	NLP P60 protein
MED134_RS01970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MED134_RS01975	COG0542	response to heat
MED134_RS01990	COG2986	histidine ammonia-lyase
MED134_RS02000	COG0302	gtp cyclohydrolase
MED134_RS02010	COG1136	(ABC) transporter
MED134_RS02020	COG5002	protein histidine kinase activity
MED134_RS02030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MED134_RS02050	COG0321	lipoyl(octanoyl) transferase activity
MED134_RS02050	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MED134_RS02060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MED134_RS02075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MED134_RS02105	COG1473	amidohydrolase
MED134_RS02110	COG1629	transport
MED134_RS02120	COG1473	amidohydrolase
MED134_RS02150	COG0542	response to heat
MED134_RS02170	COG3177	Filamentation induced by cAMP protein fic
MED134_RS02190	COG1272	protein, Hemolysin III
MED134_RS02200	COG0513	Belongs to the DEAD box helicase family
MED134_RS02210	COG0359	binds to the 23S rRNA
MED134_RS02215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MED134_RS02220	COG0360	Binds together with S18 to 16S ribosomal RNA
MED134_RS02230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MED134_RS02255	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MED134_RS02265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MED134_RS02280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MED134_RS02285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MED134_RS02310	COG1652	LysM domain
MED134_RS02310	COG2823	Periplasmic or secreted lipoprotein
MED134_RS02325	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MED134_RS02365	COG1862	Preprotein translocase
MED134_RS02375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MED134_RS02380	COG1132	(ABC) transporter
MED134_RS02395	COG0251	oxidation-reduction process
MED134_RS02400	COG0433	COG0433 Predicted ATPase
MED134_RS02410	COG0662	Cupin 2, conserved barrel domain protein
MED134_RS02410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MED134_RS02425	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MED134_RS02435	COG0131	Imidazoleglycerol-phosphate dehydratase
MED134_RS02435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MED134_RS02440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MED134_RS02445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MED134_RS02450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MED134_RS02480	COG1028	Short-chain dehydrogenase reductase Sdr
MED134_RS02485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MED134_RS02500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MED134_RS02505	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MED134_RS02510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MED134_RS02510	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MED134_RS02515	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MED134_RS02520	COG1078	dGTPase activity
MED134_RS02525	COG2204	response regulator
MED134_RS02615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MED134_RS02620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MED134_RS02625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MED134_RS02630	COG1028	Short-chain dehydrogenase reductase Sdr
MED134_RS02645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MED134_RS02650	COG2885	chlorophyll binding
MED134_RS02665	COG0022	dehydrogenase e1 component
MED134_RS02670	COG0702	epimerase
MED134_RS02695	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MED134_RS02705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MED134_RS02710	COG1193	negative regulation of DNA recombination
MED134_RS02715	COG3011	Protein conserved in bacteria
MED134_RS02720	COG1629	transport
MED134_RS02745	COG0124	histidyl-tRNA synthetase
MED134_RS02750	COG0577	efflux transmembrane transporter activity
MED134_RS02755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MED134_RS02765	COG2860	membrane
MED134_RS02795	COG0714	Associated with various cellular activities
MED134_RS02810	COG2610	gluconate transmembrane transporter activity
MED134_RS02815	COG3265	gluconokinase activity
MED134_RS02835	COG1012	belongs to the aldehyde dehydrogenase family
MED134_RS02875	COG0693	protein deglycase activity
MED134_RS02905	COG0140	phosphoribosyl-ATP diphosphatase activity
MED134_RS02905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MED134_RS02910	COG0107	imidazoleglycerol-phosphate synthase activity
MED134_RS02945	COG0477	Major facilitator Superfamily
MED134_RS02960	COG1393	Belongs to the ArsC family
MED134_RS02970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MED134_RS02980	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MED134_RS02985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MED134_RS03020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MED134_RS03020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MED134_RS03050	COG0069	glutamate synthase activity
MED134_RS03065	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MED134_RS03090	COG0488	(ABC) transporter
MED134_RS03095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MED134_RS03100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MED134_RS03105	COG0300	oxidoreductase activity
MED134_RS03115	COG0778	Nitroreductase
MED134_RS03120	COG1607	acyl-coa hydrolase
MED134_RS03125	COG2949	membrane
MED134_RS03135	COG0592	DNA-directed DNA polymerase activity
MED134_RS03140	COG2234	aminopeptidase activity
MED134_RS03150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MED134_RS03155	COG0626	cystathionine gamma-synthase activity
MED134_RS03160	COG1228	amidohydrolase
MED134_RS03210	COG3876	Protein conserved in bacteria
MED134_RS03230	COG4771	TonB-dependent receptor
MED134_RS03245	COG1120	ATPase activity
MED134_RS03265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MED134_RS03270	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MED134_RS03280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MED134_RS03285	COG0556	nucleotide-excision repair
MED134_RS03290	COG0071	Belongs to the small heat shock protein (HSP20) family
MED134_RS03340	COG2824	Alkylphosphonate utilization operon protein PhnA
MED134_RS03355	COG0482	sulfurtransferase activity
MED134_RS03365	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MED134_RS03380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MED134_RS03410	COG0519	Catalyzes the synthesis of GMP from XMP
MED134_RS03410	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MED134_RS03420	COG1522	sequence-specific DNA binding
MED134_RS03445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MED134_RS03450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MED134_RS03460	COG0254	rRNA binding
MED134_RS03480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MED134_RS03485	COG1132	(ABC) transporter
MED134_RS03510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MED134_RS03535	COG1607	acyl-coa hydrolase
MED134_RS03545	COG1301	dicarboxylic acid transport
MED134_RS03550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MED134_RS03565	COG0277	FAD linked oxidase domain protein
MED134_RS03565	COG0247	lactate metabolic process
MED134_RS03575	COG0438	transferase activity, transferring glycosyl groups
MED134_RS03580	COG1472	Belongs to the glycosyl hydrolase 3 family
MED134_RS03590	COG0247	lactate metabolic process
MED134_RS03590	COG2181	nitrate reductase activity
MED134_RS03605	COG2181	nitrate reductase activity
MED134_RS03605	COG0247	lactate metabolic process
MED134_RS03625	COG0251	oxidation-reduction process
MED134_RS03655	COG0009	L-threonylcarbamoyladenylate synthase
MED134_RS03735	COG1703	isobutyryl-CoA mutase activity
MED134_RS03735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MED134_RS03735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MED134_RS03740	COG0788	formyltetrahydrofolate deformylase activity
MED134_RS03750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MED134_RS03755	COG0284	orotidine-5'-phosphate decarboxylase activity
MED134_RS03760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MED134_RS03770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MED134_RS03835	COG0174	glutamine synthetase
MED134_RS03845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MED134_RS03855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MED134_RS03905	COG0443	Heat shock 70 kDa protein
MED134_RS03920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MED134_RS03925	COG2318	DinB family
MED134_RS03930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MED134_RS03940	COG0101	tRNA pseudouridine synthase activity
MED134_RS03945	COG1132	(ABC) transporter
MED134_RS03965	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MED134_RS03975	COG0326	Molecular chaperone. Has ATPase activity
MED134_RS03985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MED134_RS03995	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MED134_RS04000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MED134_RS04015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MED134_RS04025	COG1280	lysine exporter protein (LysE YggA)
MED134_RS04035	COG0640	Transcriptional regulator
MED134_RS04090	COG3609	addiction module antidote protein, CC2985 family
MED134_RS04115	COG0456	acetyltransferase
MED134_RS04120	COG0336	Belongs to the RNA methyltransferase TrmD family
MED134_RS04125	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MED134_RS04140	COG1522	sequence-specific DNA binding
MED134_RS04150	COG1757	Na H antiporter
MED134_RS04155	COG0450	alkyl hydroperoxide reductase
MED134_RS04160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MED134_RS04180	COG1674	ftsk spoiiie
MED134_RS04195	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MED134_RS04195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MED134_RS04225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MED134_RS04245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MED134_RS04280	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MED134_RS04285	COG0488	(ABC) transporter
MED134_RS04290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MED134_RS04300	COG4628	conserved protein (DUF2132)
MED134_RS04310	COG3956	TIGRFAM MazG family protein
MED134_RS04320	COG0242	peptide deformylase activity
MED134_RS04325	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MED134_RS04330	COG2171	N-acyltransferase activity
MED134_RS04340	COG0463	Glycosyl transferase, family 2
MED134_RS04345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MED134_RS04360	COG2183	response to ionizing radiation
MED134_RS04360	COG0539	negative regulation of cytoplasmic translation
MED134_RS04375	COG2154	pterin-4-alpha-carbinolamine dehydratase
MED134_RS04380	COG0217	transcriptional regulatory protein
MED134_RS04400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MED134_RS04410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MED134_RS04445	COG1970	mechanosensitive ion channel activity
MED134_RS04450	COG2270	Major facilitator Superfamily
MED134_RS04455	COG4783	chaperone-mediated protein folding
MED134_RS04465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MED134_RS04470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MED134_RS04475	COG0297	glycogen (starch) synthase activity
MED134_RS04480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MED134_RS04485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MED134_RS04490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MED134_RS04495	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MED134_RS04505	COG4974	Belongs to the 'phage' integrase family
MED134_RS04530	COG1266	CAAX protease self-immunity
MED134_RS04535	COG4948	Mandelate Racemase Muconate Lactonizing
MED134_RS04540	COG1678	Uncharacterized ACR, COG1678
MED134_RS04560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MED134_RS04575	COG0348	domain, Protein
MED134_RS04580	COG2010	Cytochrome c
MED134_RS04590	COG3278	Belongs to the heme-copper respiratory oxidase family
MED134_RS04605	COG2217	Heavy metal translocating P-type atpase
MED134_RS04650	COG0745	RESPONSE REGULATOR receiver
MED134_RS04655	COG5002	protein histidine kinase activity
MED134_RS04720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MED134_RS04725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MED134_RS04730	COG0440	acetolactate synthase activity
MED134_RS04735	COG0028	Belongs to the TPP enzyme family
MED134_RS04740	COG0129	dihydroxy-acid dehydratase activity
MED134_RS04745	COG1012	belongs to the aldehyde dehydrogenase family
MED134_RS04760	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MED134_RS04770	COG1914	H( )-stimulated, divalent metal cation uptake system
MED134_RS04775	COG0784	Response regulator, receiver
MED134_RS04775	COG2205	protein histidine kinase activity
MED134_RS04780	COG0606	chelatase, subunit chli
MED134_RS04805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MED134_RS04815	COG1115	amino acid carrier protein
MED134_RS04825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MED134_RS04830	COG1702	phosphate starvation-inducible protein PhoH
MED134_RS04860	COG0784	Response regulator, receiver
MED134_RS04865	COG4251	negative regulation of phosphorylation
MED134_RS04880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MED134_RS04885	COG0085	RNA polymerase activity
MED134_RS04890	COG0222	ribosome binding
MED134_RS04895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MED134_RS04900	COG0081	regulation of translation
MED134_RS04905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MED134_RS04925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MED134_RS04955	COG4974	Belongs to the 'phage' integrase family
MED134_RS04960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MED134_RS04965	COG1960	acyl-CoA dehydrogenase activity
MED134_RS04975	COG1115	amino acid carrier protein
MED134_RS04980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MED134_RS04990	COG0514	ATP-dependent DNA helicase (RecQ)
MED134_RS05000	COG0805	protein transport
MED134_RS05010	COG1137	ATPase activity
MED134_RS05040	COG3279	Response regulator of the LytR AlgR family
MED134_RS05045	COG0302	gtp cyclohydrolase
MED134_RS05050	COG0215	cysteine-tRNA ligase activity
MED134_RS05055	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MED134_RS05060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MED134_RS05070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MED134_RS05075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MED134_RS05080	COG1546	Belongs to the CinA family
MED134_RS05080	COG1058	Belongs to the CinA family
MED134_RS05095	COG2176	DNA-directed DNA polymerase activity
MED134_RS05095	COG5002	protein histidine kinase activity
MED134_RS05120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MED134_RS05125	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MED134_RS05130	COG0673	inositol 2-dehydrogenase activity
MED134_RS05135	COG1250	3-hydroxyacyl-CoA dehydrogenase
MED134_RS05150	COG1199	ATP-dependent helicase activity
MED134_RS05150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MED134_RS05155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MED134_RS05160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MED134_RS05175	COG0237	dephospho-CoA kinase activity
MED134_RS05185	COG0463	Glycosyl transferase, family 2
MED134_RS05190	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MED134_RS05195	COG0497	DNA recombination
MED134_RS05220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MED134_RS05230	COG0737	Belongs to the 5'-nucleotidase family
MED134_RS05235	COG0737	Belongs to the 5'-nucleotidase family
MED134_RS05245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MED134_RS05260	COG2890	protein-(glutamine-N5) methyltransferase activity
MED134_RS05270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MED134_RS05270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MED134_RS05320	COG1396	sequence-specific DNA binding
MED134_RS05330	COG1842	Phage shock protein A
MED134_RS05345	COG2255	four-way junction helicase activity
MED134_RS05355	COG2133	pyrroloquinoline quinone binding
MED134_RS05370	COG1192	Involved in chromosome partitioning
MED134_RS05375	COG1475	DNA binding
MED134_RS05385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MED134_RS05415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MED134_RS05425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MED134_RS05435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MED134_RS05450	COG0018	arginyl-trna synthetase
MED134_RS05460	COG1090	epimerase
MED134_RS05465	COG1959	2 iron, 2 sulfur cluster binding
MED134_RS05475	COG0492	ferredoxin-NADP+ reductase activity
MED134_RS05480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MED134_RS05485	COG0569	domain protein
MED134_RS05490	COG2226	methyltransferase
MED134_RS05500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MED134_RS05510	COG0191	fructose-bisphosphate aldolase activity
MED134_RS05515	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MED134_RS05530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MED134_RS05535	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MED134_RS05545	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MED134_RS05555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MED134_RS05590	COG1490	D-aminoacyl-tRNA deacylase activity
MED134_RS05595	COG1162	GTPase activity
MED134_RS05605	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MED134_RS05610	COG0287	Prephenate dehydrogenase
MED134_RS05615	COG0436	Aminotransferase
MED134_RS05625	COG1131	(ABC) transporter
MED134_RS05635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MED134_RS05640	COG1185	polyribonucleotide nucleotidyltransferase activity
MED134_RS05730	COG0367	asparagine synthase
MED134_RS05750	COG3540	Alkaline phosphatase
MED134_RS05755	COG0305	Participates in initiation and elongation during chromosome replication
MED134_RS05760	COG0825	malonyl-CoA metabolic process
MED134_RS05775	COG0343	queuine tRNA-ribosyltransferase activity
MED134_RS05790	COG1215	transferase activity, transferring glycosyl groups
MED134_RS05805	COG1595	DNA-templated transcription, initiation
MED134_RS05810	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MED134_RS05815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MED134_RS05820	COG0436	Aminotransferase
MED134_RS05830	COG0525	valine-tRNA ligase activity
MED134_RS05840	COG0688	phosphatidylethanolamine metabolic process
MED134_RS05845	COG4589	Belongs to the CDS family
MED134_RS05855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MED134_RS05860	COG0799	negative regulation of ribosome biogenesis
MED134_RS05865	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MED134_RS05865	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MED134_RS05870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MED134_RS05875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MED134_RS05885	COG1663	tetraacyldisaccharide 4'-kinase activity
MED134_RS05890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MED134_RS05900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MED134_RS05915	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MED134_RS05920	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MED134_RS05950	COG0811	peptide transport
MED134_RS05960	COG0252	asparaginase activity
MED134_RS05970	COG0084	hydrolase, TatD family'
MED134_RS06000	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MED134_RS06005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MED134_RS06020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MED134_RS06070	COG0488	(ABC) transporter
MED134_RS06100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MED134_RS06125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MED134_RS06130	COG3829	transcription factor binding
MED134_RS06150	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MED134_RS06155	COG0459	protein refolding
MED134_RS06220	COG0577	efflux transmembrane transporter activity
MED134_RS06220	COG1136	(ABC) transporter
MED134_RS06225	COG0138	bifunctional purine biosynthesis protein purh
MED134_RS06230	COG1077	Cell shape determining protein MreB Mrl
MED134_RS06250	COG0772	Belongs to the SEDS family
MED134_RS06265	COG0612	Peptidase, M16
MED134_RS06270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MED134_RS06275	COG0587	DNA-directed DNA polymerase activity
MED134_RS06305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MED134_RS06310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MED134_RS06315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MED134_RS06320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MED134_RS06335	COG2274	protein secretion by the type I secretion system
MED134_RS06350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MED134_RS06350	COG5297	Belongs to the glycosyl hydrolase family 6
MED134_RS06360	COG1131	(ABC) transporter
MED134_RS06375	COG0285	dihydrofolate synthase activity
MED134_RS06385	COG0848	biopolymer transport protein
MED134_RS06390	COG0811	peptide transport
MED134_RS06400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MED134_RS06405	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MED134_RS06410	COG1960	acyl-CoA dehydrogenase activity
MED134_RS06425	COG0793	Belongs to the peptidase S41A family
MED134_RS06430	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MED134_RS06440	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MED134_RS06445	COG0791	NLP P60 protein
MED134_RS06450	COG0658	competence protein
MED134_RS06450	COG2333	competence protein COMEC
MED134_RS06460	COG3104	oligopeptide transport
MED134_RS06465	COG0823	Involved in the tonB-independent uptake of proteins
MED134_RS06465	COG1506	peptidase
MED134_RS06485	COG1253	flavin adenine dinucleotide binding
MED134_RS06510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MED134_RS06540	COG1629	transport
MED134_RS06540	COG4206	TonB-dependent receptor
MED134_RS06560	COG1054	Belongs to the UPF0176 family
MED134_RS06585	COG2226	methyltransferase
MED134_RS06605	COG1733	regulation of RNA biosynthetic process
MED134_RS06655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MED134_RS06675	COG0439	Biotin carboxylase
MED134_RS06680	COG0511	ligase activity, forming carbon-carbon bonds
MED134_RS06685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MED134_RS06690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MED134_RS06700	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MED134_RS06720	COG0346	lactoylglutathione lyase activity
MED134_RS06725	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MED134_RS06730	COG4591	ABC-type transport system involved in lipoprotein release permease component
MED134_RS06735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MED134_RS06750	COG0481	GTPase activity
MED134_RS06765	COG3537	Alpha-1,2-mannosidase
MED134_RS06770	COG2897	thiosulfate sulfurtransferase activity
MED134_RS06775	COG1446	asparaginase
MED134_RS06780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MED134_RS06780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MED134_RS06795	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MED134_RS06800	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MED134_RS06805	COG0052	Belongs to the universal ribosomal protein uS2 family
MED134_RS06810	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MED134_RS06820	COG0528	UMP kinase activity
MED134_RS06825	COG0233	cytoplasmic translational termination
MED134_RS06840	COG0259	pyridoxamine-phosphate oxidase activity
MED134_RS06845	COG0017	Asparaginyl-tRNA synthetase
MED134_RS06880	COG4585	Histidine kinase
MED134_RS06905	COG2066	Belongs to the glutaminase family
MED134_RS06920	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MED134_RS06920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MED134_RS06930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MED134_RS06935	COG0501	Belongs to the peptidase M48B family
MED134_RS06940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MED134_RS06955	COG3152	Membrane
MED134_RS06975	COG1477	protein flavinylation
MED134_RS06985	COG3279	Response regulator of the LytR AlgR family
MED134_RS06990	COG2972	Histidine kinase
MED134_RS07020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MED134_RS07025	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MED134_RS07030	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MED134_RS07035	COG1805	sodium ion transport
MED134_RS07070	COG1012	belongs to the aldehyde dehydrogenase family
MED134_RS07080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MED134_RS07090	COG0646	methionine synthase
MED134_RS07090	COG1410	methionine synthase
MED134_RS07095	COG0527	aspartate kinase activity
MED134_RS07095	COG0460	homoserine dehydrogenase
MED134_RS07100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MED134_RS07110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MED134_RS07125	COG4206	TonB-dependent receptor
MED134_RS07125	COG1629	transport
MED134_RS07165	COG1428	Deoxynucleoside kinase
MED134_RS07185	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MED134_RS07190	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MED134_RS07200	COG0022	dehydrogenase e1 component
MED134_RS07200	COG0508	dehydrogenase complex catalyzes the overall conversion of
MED134_RS07205	COG2086	electron transfer activity
MED134_RS07210	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MED134_RS07220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MED134_RS07230	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MED134_RS07240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MED134_RS07245	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MED134_RS07270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MED134_RS07275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MED134_RS07300	COG1519	Transferase
MED134_RS07300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MED134_RS07365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MED134_RS07370	COG4771	TonB-dependent receptor
MED134_RS07410	COG1428	Deoxynucleoside kinase
MED134_RS07440	COG1160	GTP binding
MED134_RS07465	COG2885	chlorophyll binding
MED134_RS07465	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MED134_RS07470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MED134_RS07480	COG0544	peptidyl-prolyl cis-trans isomerase activity
MED134_RS07485	COG1950	PFAM Membrane protein of
MED134_RS07500	COG0596	Alpha beta hydrolase
MED134_RS07505	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MED134_RS07515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MED134_RS07525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MED134_RS07530	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MED134_RS07545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MED134_RS07550	COG3279	Response regulator of the LytR AlgR family
MED134_RS07575	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MED134_RS07580	COG1960	acyl-CoA dehydrogenase activity
MED134_RS07585	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MED134_RS07590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MED134_RS07595	COG0228	four-way junction DNA binding
MED134_RS07620	COG4585	Histidine kinase
MED134_RS07630	COG0508	dehydrogenase complex catalyzes the overall conversion of
MED134_RS07650	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MED134_RS07650	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MED134_RS07660	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MED134_RS07670	COG0572	uridine kinase
MED134_RS07675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MED134_RS07725	COG0166	Belongs to the GPI family
MED134_RS07735	COG3483	tryptophan 2,3-dioxygenase activity
MED134_RS07745	COG3185	4-Hydroxyphenylpyruvate dioxygenase
MED134_RS07760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MED134_RS07765	COG3938	Belongs to the proline racemase family
MED134_RS07780	COG3813	Protein conserved in bacteria
MED134_RS07785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MED134_RS07820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MED134_RS07825	COG2315	Protein conserved in bacteria
MED134_RS07855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MED134_RS07865	COG0629	single-stranded DNA binding
MED134_RS07870	COG0514	ATP-dependent DNA helicase (RecQ)
MED134_RS07875	COG0471	metal ion transport
MED134_RS07880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MED134_RS07900	COG2201	protein-glutamate methylesterase activity
MED134_RS07905	COG2201	protein-glutamate methylesterase activity
MED134_RS07915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MED134_RS07920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MED134_RS07930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MED134_RS07935	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MED134_RS07940	COG0156	8-amino-7-oxononanoate synthase activity
MED134_RS07960	COG3655	Transcriptional regulator
MED134_RS07965	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MED134_RS07975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MED134_RS07985	COG0297	glycogen (starch) synthase activity
MED134_RS07990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MED134_RS07995	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MED134_RS08015	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MED134_RS08020	COG0667	Aldo Keto reductase
MED134_RS08035	COG0708	Exodeoxyribonuclease III
MED134_RS08055	COG0423	glycine-tRNA ligase activity
MED134_RS08065	COG1040	competence protein
MED134_RS08085	COG2176	DNA-directed DNA polymerase activity
MED134_RS08085	COG5002	protein histidine kinase activity
MED134_RS08105	COG0436	Aminotransferase
MED134_RS08120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MED134_RS08125	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MED134_RS08130	COG2095	MarC family integral membrane protein
MED134_RS08145	COG0793	Belongs to the peptidase S41A family
MED134_RS08165	COG2205	protein histidine kinase activity
MED134_RS08165	COG0784	Response regulator, receiver
MED134_RS08185	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MED134_RS08195	COG0527	aspartate kinase activity
MED134_RS08215	COG0076	glutamate decarboxylase activity
MED134_RS08230	COG0346	lactoylglutathione lyase activity
MED134_RS08240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MED134_RS08260	COG2239	Acts as a magnesium transporter
MED134_RS08265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MED134_RS08280	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MED134_RS08290	COG0196	riboflavin kinase activity
MED134_RS08295	COG0193	aminoacyl-tRNA hydrolase activity
MED134_RS08300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MED134_RS08305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MED134_RS08315	COG1459	type II secretion system
MED134_RS08375	COG4968	Prepilin-type N-terminal cleavage methylation domain
MED134_RS08425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MED134_RS08445	COG4974	Belongs to the 'phage' integrase family
MED134_RS08460	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MED134_RS08460	COG1793	dna ligase
MED134_RS08465	COG1793	dna ligase
MED134_RS08470	COG1201	RNA secondary structure unwinding
MED134_RS08475	COG0123	including yeast histone deacetylase and acetoin utilization protein
MED134_RS08495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MED134_RS08495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MED134_RS08510	COG1619	proteins homologs of microcin C7 resistance protein MccF
MED134_RS08515	COG0792	nuclease activity
MED134_RS08540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MED134_RS08560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MED134_RS08585	COG0484	heat shock protein binding
MED134_RS08595	COG1418	mRNA catabolic process
MED134_RS08615	COG0673	inositol 2-dehydrogenase activity
MED134_RS08620	COG1024	Enoyl-CoA hydratase
MED134_RS08630	COG1981	membrane
MED134_RS08655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MED134_RS08665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MED134_RS08670	COG0181	hydroxymethylbilane synthase activity
MED134_RS08680	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MED134_RS08690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MED134_RS08700	COG0408	coproporphyrinogen oxidase activity
MED134_RS08710	COG0113	porphobilinogen synthase activity
MED134_RS08720	COG1253	flavin adenine dinucleotide binding
MED134_RS08760	COG4172	Belongs to the ABC transporter superfamily
MED134_RS08775	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MED134_RS08780	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MED134_RS08790	COG1774	PSP1 C-terminal conserved region
MED134_RS08800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MED134_RS08805	COG1595	DNA-templated transcription, initiation
MED134_RS08815	COG0204	Acyl-transferase
MED134_RS08820	COG0180	Tryptophanyl-tRNA synthetase
MED134_RS08825	COG0720	synthase
MED134_RS08830	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MED134_RS08835	COG0596	Alpha beta hydrolase
MED134_RS08840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MED134_RS08840	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MED134_RS08855	COG1404	Belongs to the peptidase S8 family
MED134_RS08865	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MED134_RS08880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MED134_RS08885	COG2198	Histidine kinase
MED134_RS08885	COG0784	Response regulator, receiver
MED134_RS08885	COG0643	Histidine kinase
MED134_RS08895	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MED134_RS08905	COG0189	ligase activity
MED134_RS08915	COG0322	excinuclease ABC activity
MED134_RS08920	COG1752	Esterase of the alpha-beta hydrolase superfamily
MED134_RS08930	COG0469	pyruvate kinase activity
MED134_RS08940	COG0784	Response regulator, receiver
MED134_RS08940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MED134_RS08940	COG2198	Histidine kinase
MED134_RS08940	COG2205	protein histidine kinase activity
MED134_RS08945	COG0571	ribonuclease III activity
MED134_RS08950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MED134_RS08955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MED134_RS08965	COG3341	Caulimovirus viroplasmin
MED134_RS08965	COG0328	RNA-DNA hybrid ribonuclease activity
MED134_RS08980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MED134_RS08985	COG1074	ATP-dependent DNA helicase activity
MED134_RS08990	COG0156	8-amino-7-oxononanoate synthase activity
MED134_RS09015	COG0456	acetyltransferase
MED134_RS09030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MED134_RS09050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MED134_RS09055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MED134_RS09060	COG0594	ribonuclease P activity
MED134_RS09065	COG0793	Belongs to the peptidase S41A family
MED134_RS09080	COG2153	protein acetylation
MED134_RS09085	COG0698	ribose 5-phosphate isomerase
MED134_RS09090	COG0557	exoribonuclease II activity
MED134_RS09120	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
MED134_RS09125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MED134_RS09155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MED134_RS09170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MED134_RS09175	COG0445	tRNA wobble uridine modification
MED134_RS09180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MED134_RS09190	COG0470	DNA polymerase III
MED134_RS09195	COG0126	phosphoglycerate kinase activity
MED134_RS09200	COG3942	CHAP domain
MED134_RS09200	COG1388	LysM domain
MED134_RS09215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MED134_RS09220	COG4942	peptidase
MED134_RS09240	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MED134_RS09245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MED134_RS09255	COG2244	polysaccharide biosynthetic process
MED134_RS09280	COG0110	maltose O-acetyltransferase activity
MED134_RS09285	COG0297	glycogen (starch) synthase activity
MED134_RS09290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MED134_RS09300	COG1215	transferase activity, transferring glycosyl groups
MED134_RS09315	COG0151	Belongs to the GarS family
MED134_RS09350	COG2022	thiamine diphosphate biosynthetic process
MED134_RS09355	COG1131	(ABC) transporter
MED134_RS09365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MED134_RS09375	COG4152	abc transporter atp-binding protein
MED134_RS09400	COG0356	it plays a direct role in the translocation of protons across the membrane
MED134_RS09405	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MED134_RS09410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MED134_RS09415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MED134_RS09420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MED134_RS09425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MED134_RS09450	COG0756	dUTP diphosphatase activity
MED134_RS09455	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MED134_RS09485	COG1607	acyl-coa hydrolase
MED134_RS09495	COG0758	DNA mediated transformation
MED134_RS09495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MED134_RS09505	COG1652	LysM domain
MED134_RS09515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MED134_RS09525	COG0194	GDP metabolic process
MED134_RS09530	COG1561	YicC-like family, N-terminal region
MED134_RS09560	COG0673	inositol 2-dehydrogenase activity
MED134_RS09565	COG2211	Major facilitator Superfamily
MED134_RS09590	COG2177	Part of the ABC transporter FtsEX involved in
MED134_RS09600	COG1968	undecaprenyl-diphosphatase activity
MED134_RS09605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MED134_RS09620	COG0519	Catalyzes the synthesis of GMP from XMP
MED134_RS09625	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MED134_RS09635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MED134_RS09640	COG4260	virion core protein, lumpy skin disease virus
MED134_RS09650	COG1764	response to oxidative stress
MED134_RS09670	COG1012	belongs to the aldehyde dehydrogenase family
MED134_RS09675	COG0662	Cupin 2, conserved barrel domain protein
MED134_RS09715	COG3590	peptidase
MED134_RS09735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MED134_RS09745	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
MED134_RS09750	COG0429	hydrolase of the alpha beta-hydrolase fold
MED134_RS09795	COG0626	cystathionine gamma-synthase activity
MED134_RS09805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MED134_RS09815	COG1381	Involved in DNA repair and RecF pathway recombination
MED134_RS09820	COG4771	TonB-dependent receptor
MED134_RS09825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MED134_RS09840	COG1435	thymidine kinase activity
MED134_RS09845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MED134_RS09850	COG1970	mechanosensitive ion channel activity
MED134_RS09855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MED134_RS09870	COG1505	serine-type exopeptidase activity
MED134_RS09875	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MED134_RS09890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MED134_RS09905	COG0659	secondary active sulfate transmembrane transporter activity
MED134_RS09915	COG0659	secondary active sulfate transmembrane transporter activity
MED134_RS09940	COG2304	oxidoreductase activity
MED134_RS09945	COG2304	oxidoreductase activity
MED134_RS09960	COG0714	Associated with various cellular activities
MED134_RS09965	COG4989	oxidoreductase activity
MED134_RS09970	COG4221	oxidoreductase activity
MED134_RS09985	COG3852	Histidine kinase
MED134_RS10005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MED134_RS10025	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MED134_RS10055	COG0415	Belongs to the DNA photolyase family
MED134_RS10060	COG3046	protein related to deoxyribodipyrimidine photolyase
MED134_RS10065	COG0415	Belongs to the DNA photolyase family
MED134_RS10100	COG4585	Histidine kinase
MED134_RS10120	COG0740	serine-type endopeptidase activity
MED134_RS10125	COG3118	belongs to the thioredoxin family
MED134_RS10135	COG0686	Belongs to the AlaDH PNT family
MED134_RS10145	COG0495	leucyl-tRNA aminoacylation
MED134_RS10155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MED134_RS10175	COG1522	sequence-specific DNA binding
MED134_RS10185	COG2363	Small membrane protein
MED134_RS10190	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MED134_RS10210	COG0629	single-stranded DNA binding
MED134_RS10230	COG0776	regulation of translation
MED134_RS10235	COG1530	ribonuclease E activity
MED134_RS10240	COG2137	regulation of response to DNA damage stimulus
MED134_RS10250	COG4566	intracellular signal transduction
MED134_RS10255	COG4771	TonB-dependent receptor
MED134_RS10260	COG1321	iron dependent repressor
MED134_RS10260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MED134_RS10265	COG0803	Belongs to the bacterial solute-binding protein 9 family
MED134_RS10270	COG1121	(ABC) transporter
MED134_RS10280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MED134_RS10285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MED134_RS10305	COG1999	signal sequence binding
MED134_RS10310	COG0750	zinc metalloprotease
MED134_RS10370	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MED134_RS10375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MED134_RS10395	COG2954	triphosphatase activity
MED134_RS10415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MED134_RS10430	COG0668	transmembrane transport
MED134_RS10465	COG1028	Short-chain dehydrogenase reductase Sdr
MED134_RS10470	COG2271	Major facilitator Superfamily
MED134_RS10475	COG2186	Transcriptional regulator
MED134_RS10495	COG4771	TonB-dependent receptor
MED134_RS10570	COG3275	phosphorelay sensor kinase activity
MED134_RS10575	COG3279	Response regulator of the LytR AlgR family
MED134_RS10585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MED134_RS10590	COG2814	Major facilitator Superfamily
MED134_RS10595	COG1621	beta-fructofuranosidase activity
MED134_RS10605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MED134_RS10655	COG1629	transport
MED134_RS10660	COG2081	HI0933 family
MED134_RS10690	COG1278	Cold shock
MED134_RS10700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MED134_RS10720	COG0463	Glycosyl transferase, family 2
MED134_RS10725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MED134_RS10740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MED134_RS10760	COG0745	RESPONSE REGULATOR receiver
MED134_RS10765	COG5002	protein histidine kinase activity
MED134_RS10775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MED134_RS10790	COG0489	protein tyrosine kinase activity
MED134_RS10800	COG0492	ferredoxin-NADP+ reductase activity
MED134_RS10805	COG0633	Ferredoxin
MED134_RS10845	COG2151	metal-sulfur cluster biosynthetic enzyme
MED134_RS10850	COG2166	iron-sulfur cluster assembly
MED134_RS10870	COG0719	Fe-S assembly protein
MED134_RS10875	COG0396	ATPase activity
MED134_RS10890	COG0719	Fe-S assembly protein
MED134_RS10905	COG4772	TonB-dependent receptor
MED134_RS10925	COG1858	cytochrome C peroxidase
MED134_RS10950	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MED134_RS10960	COG2267	carboxylic ester hydrolase activity
MED134_RS10965	COG1114	Component of the transport system for branched-chain amino acids
MED134_RS10975	COG0527	aspartate kinase activity
MED134_RS10980	COG0006	proline dipeptidase activity
MED134_RS10995	COG1053	succinate dehydrogenase
MED134_RS11025	COG1629	transport
MED134_RS11035	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MED134_RS11040	COG1404	Belongs to the peptidase S8 family
MED134_RS11045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MED134_RS11070	COG0848	biopolymer transport protein
MED134_RS11075	COG1187	pseudouridine synthase activity
MED134_RS11080	COG0463	Glycosyl transferase, family 2
MED134_RS11100	COG1215	transferase activity, transferring glycosyl groups
MED134_RS11105	COG0463	Glycosyl transferase, family 2
MED134_RS11125	COG3842	ATPase activity
MED134_RS11130	COG1482	cell wall glycoprotein biosynthetic process
MED134_RS11145	COG0726	polysaccharide deacetylase
MED134_RS11170	COG0779	Required for maturation of 30S ribosomal subunits
MED134_RS11175	COG2251	uridine kinase activity
MED134_RS11175	COG0195	Participates in both transcription termination and antitermination
MED134_RS11180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MED134_RS11195	COG0437	4 iron, 4 sulfur cluster binding
MED134_RS11220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MED134_RS11225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MED134_RS11230	COG2255	four-way junction helicase activity
MED134_RS11240	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MED134_RS11260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MED134_RS11265	COG0281	malic enzyme
MED134_RS11265	COG0280	phosphate acetyltransferase
MED134_RS11270	COG0632	four-way junction helicase activity
MED134_RS11280	COG0509	glycine decarboxylation via glycine cleavage system
MED134_RS11315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MED134_RS11320	COG0109	protoheme IX farnesyltransferase activity
MED134_RS11350	COG2322	membrane
MED134_RS11365	COG4206	TonB-dependent receptor
MED134_RS11375	COG1136	(ABC) transporter
MED134_RS11380	COG0577	efflux transmembrane transporter activity
MED134_RS11380	COG1136	(ABC) transporter
MED134_RS11385	COG1136	(ABC) transporter
MED134_RS11385	COG0577	efflux transmembrane transporter activity
MED134_RS11390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MED134_RS11400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MED134_RS11405	COG1214	PFAM Peptidase M22, glycoprotease
MED134_RS11415	COG0668	transmembrane transport
MED134_RS11420	COG1331	Highly conserved protein containing a thioredoxin domain
MED134_RS11440	COG1704	LemA family
MED134_RS11450	COG0739	heme binding
MED134_RS11455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MED134_RS11470	COG3186	Phenylalanine-4-hydroxylase
MED134_RS11485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MED134_RS11490	COG3396	Phenylacetate-CoA oxygenase
MED134_RS11495	COG3460	Phenylacetate-CoA oxygenase
MED134_RS11500	COG3396	Phenylacetate-CoA oxygenase
MED134_RS11505	COG2151	metal-sulfur cluster biosynthetic enzyme
MED134_RS11510	COG1024	Enoyl-CoA hydratase
MED134_RS11515	COG1250	3-hydroxyacyl-CoA dehydrogenase
MED134_RS11525	COG0183	Belongs to the thiolase family
MED134_RS11535	COG1012	belongs to the aldehyde dehydrogenase family
MED134_RS11535	COG2030	dehydratase
MED134_RS11560	COG0508	dehydrogenase complex catalyzes the overall conversion of
MED134_RS11565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MED134_RS11570	COG0022	dehydrogenase e1 component
MED134_RS11590	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MED134_RS11595	COG1705	Flagellar rod assembly protein muramidase FlgJ
MED134_RS11595	COG1388	LysM domain
MED134_RS11600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MED134_RS11620	COG4682	membrane
MED134_RS11645	COG1629	transport
MED134_RS11650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MED134_RS11660	COG0321	lipoyl(octanoyl) transferase activity
MED134_RS11670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MED134_RS11715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MED134_RS11730	COG1418	mRNA catabolic process
MED134_RS11740	COG0137	argininosuccinate synthase activity
MED134_RS11745	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MED134_RS11750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MED134_RS11755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MED134_RS11765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MED134_RS11770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MED134_RS11775	COG0165	Argininosuccinate lyase
MED134_RS11795	COG0066	3-isopropylmalate dehydratase activity
MED134_RS11800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MED134_RS11805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MED134_RS11820	COG0564	pseudouridine synthase activity
MED134_RS11825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MED134_RS11840	COG1760	l-serine dehydratase
MED134_RS11845	COG0456	acetyltransferase
MED134_RS11855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MED134_RS11860	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MED134_RS11865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MED134_RS11870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MED134_RS11875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MED134_RS11890	COG0295	cytidine deaminase activity
MED134_RS11895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MED134_RS11910	COG1028	Short-chain dehydrogenase reductase Sdr
MED134_RS11920	COG0662	Cupin 2, conserved barrel domain protein
MED134_RS11920	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MED134_RS11935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MED134_RS11940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MED134_RS11945	COG1785	Belongs to the alkaline phosphatase family
MED134_RS11960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MED134_RS11965	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MED134_RS11965	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MED134_RS11990	COG1090	epimerase
MED134_RS12010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MED134_RS12015	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MED134_RS12020	COG0563	adenylate kinase activity
MED134_RS12025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MED134_RS12045	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MED134_RS12090	COG3340	Belongs to the peptidase S51 family
MED134_RS12130	COG2095	MarC family integral membrane protein
MED134_RS12140	COG2003	Belongs to the UPF0758 family
MED134_RS12175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MED134_RS12205	COG1629	transport
MED134_RS12215	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MED134_RS12220	COG0049	tRNA binding
MED134_RS12225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MED134_RS12230	COG0051	transcription antitermination factor activity, RNA binding
MED134_RS12235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MED134_RS12240	COG0088	Forms part of the polypeptide exit tunnel
MED134_RS12245	COG0089	rRNA binding
MED134_RS12250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MED134_RS12255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MED134_RS12260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MED134_RS12265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MED134_RS12270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MED134_RS12275	COG0255	Belongs to the universal ribosomal protein uL29 family
MED134_RS12280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MED134_RS12285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MED134_RS12290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MED134_RS12295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MED134_RS12300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MED134_RS12305	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MED134_RS12310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MED134_RS12320	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MED134_RS12325	COG1841	ribosomal large subunit assembly
MED134_RS12330	COG0200	Binds to the 23S rRNA
MED134_RS12335	COG0201	protein transport
MED134_RS12340	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MED134_RS12345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MED134_RS12350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MED134_RS12355	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MED134_RS12360	COG0202	RNA polymerase activity
MED134_RS12365	COG0203	ribosomal protein L17
MED134_RS12375	COG0505	Belongs to the CarA family
MED134_RS12380	COG0148	phosphopyruvate hydratase activity
MED134_RS12395	COG1834	amidinotransferase
MED134_RS12405	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MED134_RS12420	COG0436	Aminotransferase
MED134_RS12425	COG3239	Fatty acid desaturase
MED134_RS12430	COG0357	Ribosomal RNA small subunit methyltransferase G
MED134_RS12450	COG0358	DNA primase activity
MED134_RS12455	COG2197	response regulator
MED134_RS12460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MED134_RS12480	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MED134_RS12490	COG2001	Belongs to the MraZ family
MED134_RS12495	COG0275	rRNA processing
MED134_RS12505	COG0768	penicillin binding
MED134_RS12510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MED134_RS12515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MED134_RS12520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MED134_RS12525	COG0772	Belongs to the SEDS family
MED134_RS12530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MED134_RS12535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MED134_RS12550	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MED134_RS12555	COG1610	YqeY-like protein
MED134_RS12560	COG2885	chlorophyll binding
MED134_RS12580	COG0783	Belongs to the Dps family
MED134_RS12605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MED134_RS12605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MED134_RS12610	COG0730	response to heat
MED134_RS12630	COG1045	serine acetyltransferase
MED134_RS12640	COG1595	DNA-templated transcription, initiation
MED134_RS12675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MED134_RS12680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MED134_RS12685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MED134_RS12690	COG0671	phosphoesterase, PA-phosphatase related
MED134_RS12695	COG1404	Belongs to the peptidase S8 family
MED134_RS12715	COG1028	Short-chain dehydrogenase reductase Sdr
MED134_RS12725	COG2827	Endonuclease containing a URI domain
MED134_RS12735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MED134_RS12740	COG2808	Putative FMN-binding domain
MED134_RS12745	COG3844	kynureninase activity
MED134_RS12760	COG0602	queuosine metabolic process
MED134_RS12765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MED134_RS12775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MED134_RS12780	COG0039	L-malate dehydrogenase activity
MED134_RS12790	COG0187	DNA topoisomerase II activity
MED134_RS12800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MED134_RS12805	COG0552	protein localization to endoplasmic reticulum
MED134_RS12820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MED134_RS12835	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MED134_RS12865	COG1215	transferase activity, transferring glycosyl groups
MED134_RS12870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MED134_RS12890	COG0789	Transcriptional regulator
MED134_RS12910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MED134_RS12915	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MED134_RS12920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MED134_RS12935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MED134_RS12940	COG3959	Transketolase, thiamine diphosphate binding domain
MED134_RS12950	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MED134_RS12985	COG3022	response to hydroperoxide
MED134_RS12995	COG0564	pseudouridine synthase activity
MED134_RS13005	COG1181	Belongs to the D-alanine--D-alanine ligase family
MED134_RS13010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MED134_RS13015	COG0159	tryptophan synthase activity
MED134_RS13020	COG0133	tryptophan synthase activity
MED134_RS13025	COG0135	phosphoribosylanthranilate isomerase activity
MED134_RS13035	COG0134	indole-3-glycerol-phosphate synthase activity
MED134_RS13040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MED134_RS13050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MED134_RS13050	COG0512	Glutamine amidotransferase of anthranilate synthase
MED134_RS13055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MED134_RS13060	COG2353	YceI-like domain
MED134_RS13080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MED134_RS13090	COG1858	cytochrome C peroxidase
MED134_RS13105	COG0312	modulator of DNA gyrase
MED134_RS13110	COG0312	modulator of DNA gyrase
MED134_RS13120	COG0714	Associated with various cellular activities
MED134_RS13200	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MED134_RS13205	COG0484	heat shock protein binding
MED134_RS13210	COG4152	abc transporter atp-binding protein
MED134_RS13220	COG1196	nuclear chromosome segregation
MED134_RS13220	COG3264	Mechanosensitive ion channel
MED134_RS13230	COG2204	response regulator
MED134_RS13235	COG2326	polyphosphate kinase activity
MED134_RS13250	COG0534	Mate efflux family protein
MED134_RS13260	COG0671	phosphoesterase, PA-phosphatase related
MED134_RS13300	COG0561	phosphatase activity
MED134_RS13305	COG0653	protein targeting
MED134_RS13325	COG1136	(ABC) transporter
MED134_RS13335	COG0488	(ABC) transporter
MED134_RS13345	COG0489	protein tyrosine kinase activity
MED134_RS13370	COG0463	Glycosyl transferase, family 2
MED134_RS13380	COG1216	Glycosyl transferase, family 2
MED134_RS13400	COG1216	Glycosyl transferase, family 2
MED134_RS13420	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MED134_RS13425	COG2089	acid synthase
MED134_RS13455	COG1045	serine acetyltransferase
MED134_RS13480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MED134_RS13495	COG0045	succinate-CoA ligase (ADP-forming) activity
MED134_RS13505	COG2264	protein methyltransferase activity
MED134_RS13520	COG0149	triose-phosphate isomerase activity
MED134_RS13525	COG0601	transmembrane transport
MED134_RS13540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MED134_RS13560	COG2195	Cleaves the N-terminal amino acid of tripeptides
MED134_RS13565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MED134_RS13575	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MED134_RS13580	COG0105	UTP biosynthetic process
MED134_RS13590	COG1217	gtp-binding protein TYPA
MED134_RS13640	COG1216	Glycosyl transferase, family 2
MED134_RS13640	COG0463	Glycosyl transferase, family 2
MED134_RS13650	COG2884	Cell division ATP-binding protein ftsE
MED134_RS13675	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MED134_RS13680	COG3530	Putative quorum-sensing-regulated virulence factor
MED134_RS13685	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MED134_RS13695	COG0004	ammonium transporteR
MED134_RS13705	COG0070	glutamate synthase
MED134_RS13705	COG0069	glutamate synthase activity
MED134_RS13705	COG0067	glutamate synthase
MED134_RS13710	COG0493	'glutamate synthase
MED134_RS13715	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MED134_RS13725	COG1739	Uncharacterized protein family UPF0029
MED134_RS13730	COG4166	transmembrane transport
MED134_RS13735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MED134_RS13750	COG2050	protein possibly involved in aromatic compounds catabolism
MED134_RS13760	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MED134_RS13770	COG2996	Protein conserved in bacteria
MED134_RS13790	COG2211	Major facilitator Superfamily
MED134_RS13815	COG1363	Peptidase, m42
MED134_RS13850	COG0116	Belongs to the methyltransferase superfamily
MED134_RS13865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MED134_RS13870	COG0668	transmembrane transport
MED134_RS13875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MED134_RS13930	COG0335	large ribosomal subunit rRNA binding
MED134_RS13935	COG0268	Binds directly to 16S ribosomal RNA
MED134_RS13950	COG0442	prolyl-tRNA aminoacylation
MED134_RS13965	COG0431	NADPH-dependent FMN reductase
MED134_RS13970	COG0366	Alpha amylase catalytic
MED134_RS13975	COG1575	Belongs to the MenA family. Type 1 subfamily
MED134_RS13985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MED134_RS13990	COG0514	ATP-dependent DNA helicase (RecQ)
MED134_RS14010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MED134_RS14015	COG0584	glycerophosphoryl diester phosphodiesterase
MED134_RS14020	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MED134_RS14025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MED134_RS14030	COG0363	glucosamine-6-phosphate deaminase activity
MED134_RS14035	COG0488	(ABC) transporter
MED134_RS14045	COG0346	lactoylglutathione lyase activity
MED134_RS14050	COG1473	amidohydrolase
MED134_RS14060	COG0415	Belongs to the DNA photolyase family
MED134_RS14090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MED134_RS14105	COG1612	heme a metabolic process
MED134_RS14125	COG1131	(ABC) transporter
MED134_RS14150	COG0617	tRNA 3'-terminal CCA addition
MED134_RS14155	COG0009	L-threonylcarbamoyladenylate synthase
MED134_RS14175	COG0513	Belongs to the DEAD box helicase family
MED134_RS14205	COG0516	GMP reductase activity
MED134_RS14205	COG0517	IMP dehydrogenase activity
MED134_RS14215	COG0504	CTP synthase activity
MED134_RS14220	COG0706	membrane insertase activity
MED134_RS14260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MED134_RS14275	COG0156	8-amino-7-oxononanoate synthase activity
MED134_RS14290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MED134_RS14320	COG2356	endonuclease I
MED134_RS14335	COG0393	Putative heavy-metal-binding
MED134_RS14345	COG1115	amino acid carrier protein
MED134_RS14350	COG1741	Belongs to the pirin family
MED134_RS14410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MED134_RS14410	COG2207	Transcriptional regulator
MED134_RS14480	COG0175	sulfate reduction
MED134_RS14485	COG0175	sulfate reduction
MED134_RS14490	COG2895	sulfate adenylyltransferase (ATP) activity
MED134_RS14495	COG0659	secondary active sulfate transmembrane transporter activity
MED134_RS14510	COG2972	Histidine kinase
MED134_RS14515	COG0861	Integral membrane protein TerC family
MED134_RS14535	COG1522	sequence-specific DNA binding
MED134_RS14545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MED134_RS14565	COG0686	Belongs to the AlaDH PNT family
MED134_RS14580	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MED134_RS14680	COG1629	transport
MED134_RS14700	COG2755	lipolytic protein G-D-S-L family
MED134_RS14700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MED134_RS14710	COG3548	integral membrane protein
MED134_RS14720	COG4251	negative regulation of phosphorylation
MED134_RS14725	COG4251	negative regulation of phosphorylation
MED134_RS14800	COG0784	Response regulator, receiver
MED134_RS14800	COG2205	protein histidine kinase activity
MED134_RS14810	COG1216	Glycosyl transferase, family 2