locus-tag class description HH212_RS00140 ENOG4105DH7 May be involved in recombination (By similarity) HH212_RS00195 ENOG4105BZU Histidine kinase HH212_RS00200 ENOG4105D58 Diguanylate phosphodiesterase HH212_RS00215 ENOG4105D22 carbon starvation protein HH212_RS00220 ENOG4105VCD cytoplasmic protein HH212_RS00225 ENOG4105BZU Histidine kinase HH212_RS00230 ENOG4105BZU Histidine kinase HH212_RS00250 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HH212_RS00255 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HH212_RS00260 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HH212_RS00265 ENOG4107QMP dna polymerase iii subunits gamma and tau HH212_RS00270 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS00280 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HH212_RS00290 ENOG4107YIM Involved in the transcription termination process (By similarity) HH212_RS00295 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HH212_RS00300 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HH212_RS00305 ENOG4107RAN Peptidase, M16 HH212_RS00310 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HH212_RS00320 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HH212_RS00350 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HH212_RS00355 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HH212_RS00360 ENOG4105EMU Dehydrogenase HH212_RS00365 ENOG4107YD3 Thioesterase HH212_RS00370 ENOG4105E02 MotA TolQ exbB proton channel HH212_RS00385 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HH212_RS00390 ENOG4105KCK Peptidoglycan-associated lipoprotein HH212_RS00395 ENOG4105UFD tol-pal system protein YbgF HH212_RS00440 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HH212_RS00455 ENOG410624X efflux transporter, rnd family, mfp subunit HH212_RS00485 ENOG4108YZN class I peptide chain release factor HH212_RS00505 ENOG4106RHG Yeca family HH212_RS00510 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HH212_RS00520 ENOG4105BZU Histidine kinase HH212_RS00525 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HH212_RS00530 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HH212_RS00535 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HH212_RS00540 ENOG4105DBV ornithine carbamoyltransferase HH212_RS00545 ENOG4105CDH Citrulline--aspartate ligase HH212_RS00550 ENOG4108IU3 tonb-dependent siderophore receptor HH212_RS00565 ENOG4105D4A Cell wall formation (By similarity) HH212_RS00570 ENOG4108VPT UPF0234 protein HH212_RS00575 ENOG4105EA8 2-Nitropropane dioxygenase HH212_RS00580 ENOG4105BZU Histidine kinase HH212_RS00590 ENOG4108HRK Histidine kinase HH212_RS00595 ENOG4108VAC response regulator HH212_RS00600 ENOG4105BZU Histidine kinase HH212_RS00615 ENOG4107R11 Transcriptional regulator HH212_RS00620 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HH212_RS00645 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HH212_RS00660 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HH212_RS00665 ENOG4108K5H permease YjgP YjgQ family protein HH212_RS00675 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HH212_RS00695 ENOG4105CGK Exodeoxyribonuclease III HH212_RS00700 ENOG4105BZU Histidine kinase HH212_RS00705 ENOG4105C7F AcnD-accessory protein PrpF HH212_RS00710 ENOG4108I0Z Aconitate hydratase HH212_RS00715 ENOG4105BZN citrate synthase HH212_RS00720 ENOG4105CR4 methylisocitrate lyase HH212_RS00725 ENOG4107QN1 sodium solute HH212_RS00735 ENOG4108JU7 Transcriptional regulator HH212_RS00745 ENOG4105C28 cystathionine HH212_RS00750 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH212_RS00755 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HH212_RS00760 ENOG4105VEQ Cold shock protein HH212_RS00770 ENOG4108R99 pseudouridine synthase HH212_RS00775 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) HH212_RS00780 ENOG4105CJR Integral membrane protein (MviN HH212_RS00790 ENOG4108VAU general secretion pathway protein G HH212_RS00825 ENOG4107QHF type ii secretion system protein e HH212_RS00835 ENOG4108VAU general secretion pathway protein G HH212_RS00845 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HH212_RS00850 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HH212_RS00870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HH212_RS00905 ENOG4105CMR udp-glucose 4-epimerase HH212_RS00915 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HH212_RS00925 ENOG4105E2K Glycosyl transferase (Group 1 HH212_RS00950 ENOG4105K64 Glycosyl transferase, family 2 HH212_RS01000 ENOG4105C30 Nad-dependent epimerase dehydratase HH212_RS01005 ENOG4105C0K Gdp-mannose 4,6-dehydratase HH212_RS01010 ENOG4105D3Q Sugar transferase HH212_RS01025 ENOG4105C5H ABC transporter HH212_RS01035 ENOG4105CHH sulfate transporter HH212_RS01040 ENOG4108VYJ response regulator receiver protein HH212_RS01045 ENOG4105BZU Histidine kinase HH212_RS01050 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HH212_RS01070 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HH212_RS01080 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HH212_RS01085 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HH212_RS01090 ENOG4105W49 UPF0434 protein HH212_RS01095 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HH212_RS01100 ENOG4105M15 transport protein ExbD HH212_RS01110 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HH212_RS01130 ENOG4107EXC regulatoR HH212_RS01145 ENOG4105JJR Histidine kinase HH212_RS01185 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HH212_RS01190 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HH212_RS01205 ENOG4105DGU Histone deacetylase HH212_RS01210 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HH212_RS01220 ENOG4105F8C transglutaminase domain-containing protein HH212_RS01225 ENOG4105CVE Lytic murein transglycosylase HH212_RS01235 ENOG4105C6T cysteine synthase HH212_RS01245 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HH212_RS01250 ENOG4105C6Y Udp-glucose 6-dehydrogenase HH212_RS01255 ENOG4105CFV Tetratricopeptide repeat protein HH212_RS01265 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HH212_RS01270 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HH212_RS01275 ENOG4105CAT Cytidine monophosphate kinase HH212_RS01280 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HH212_RS01295 ENOG4105CQC Prephenate dehydratase HH212_RS01300 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HH212_RS01310 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HH212_RS01315 ENOG4105UYK outer membrane protein a HH212_RS01320 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HH212_RS01325 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HH212_RS01350 ENOG4108Z0Z intracellular protease Pfpi family HH212_RS01355 ENOG4107RKG DJ-1/PfpI family HH212_RS01375 ENOG4107QI1 Mate efflux family protein HH212_RS01410 ENOG4105C9K Endothelin-converting enzyme 1 HH212_RS01425 ENOG4105C9Q fumarate hydratase class II HH212_RS01440 ENOG4105E18 UPF0276 protein HH212_RS01455 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HH212_RS01500 ENOG4105DQ6 Transposase HH212_RS01535 ENOG4105D0M Protease HtpX homolog HH212_RS01540 ENOG4105IPI Membrane HH212_RS01550 ENOG4105CE4 GlcNAc 6-P deacetylase HH212_RS01555 ENOG4105D17 glycoside hydrolase, family 3 domain protein HH212_RS01570 ENOG4105FDP GntR family transcriptional regulator HH212_RS01590 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HH212_RS01610 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HH212_RS01615 ENOG4105P8F nudix hydrolase HH212_RS01620 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HH212_RS01625 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HH212_RS01630 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HH212_RS01635 ENOG4105K5M 30s ribosomal protein S16 HH212_RS01650 ENOG4105CSU acyl-Coa dehydrogenase HH212_RS01655 ENOG4105C10 Electron transfer flavoprotein HH212_RS01660 ENOG4105BZJ Electron transfer flavoprotein HH212_RS01665 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HH212_RS01670 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HH212_RS01675 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HH212_RS01700 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HH212_RS01710 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HH212_RS01725 ENOG4105D94 Major Facilitator Superfamily HH212_RS01745 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HH212_RS01750 ENOG4105CX6 glutaminyL-tRNA synthetase HH212_RS01755 ENOG4105BZU Histidine kinase HH212_RS01790 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HH212_RS01800 ENOG4105CJB Exodeoxyribonuclease I HH212_RS01805 ENOG4105SKN orotidine 5''-phosphate decarboxylase HH212_RS01810 ENOG4108V0P LemA family HH212_RS01825 ENOG4105CHR reductase HH212_RS01835 ENOG4105C01 Dihydroxy-acid dehydratase HH212_RS01860 ENOG4105CNT hydrolase family 2 HH212_RS01865 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HH212_RS01875 ENOG4105EUB pirin domain protein HH212_RS01895 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH212_RS01900 ENOG4105ETP RND efflux system, outer membrane lipoprotein HH212_RS01905 ENOG4105CW7 secretion protein, HlyD family HH212_RS01915 ENOG4105C5I Dehydrogenase HH212_RS01930 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS01945 ENOG41062B0 ABC transporter, permease HH212_RS01950 ENOG4107R9N ABC transporter HH212_RS01955 ENOG4105C2J ABC transporter HH212_RS01960 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HH212_RS01975 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HH212_RS01980 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HH212_RS01985 ENOG4105CGS Alpha-glucosidase HH212_RS02005 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HH212_RS02010 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HH212_RS02015 ENOG4105CT4 transporter HH212_RS02030 ENOG4105BZU Histidine kinase HH212_RS02035 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HH212_RS02040 ENOG4105K56 Transcriptional regulator HH212_RS02050 ENOG4105BZU Histidine kinase HH212_RS02055 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HH212_RS02060 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HH212_RS02065 ENOG4105C7W Xanthine dehydrogenase HH212_RS02070 ENOG4105BZU Histidine kinase HH212_RS02075 ENOG4108YIQ Alpha beta hydrolase HH212_RS02095 ENOG4105E0K tonB-dependent siderophore receptor HH212_RS02105 ENOG4105C6K Malic enzyme HH212_RS02130 ENOG4105F4R Transcriptional regulator mode HH212_RS02160 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HH212_RS02165 ENOG4108TEB UPF0114 protein HH212_RS02175 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HH212_RS02200 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS02205 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HH212_RS02215 ENOG4107MMM Anti-sigma-factor antagonist HH212_RS02220 ENOG4105C08 Histidine kinase HH212_RS02230 ENOG4105BZU Histidine kinase HH212_RS02245 ENOG4105BZU Histidine kinase HH212_RS02255 ENOG4108UT2 hemolysin iii HH212_RS02265 ENOG4105BZU Histidine kinase HH212_RS02275 ENOG4105BZU Histidine kinase HH212_RS02305 ENOG4105I03 Flagellin HH212_RS02320 ENOG4105CHR reductase HH212_RS02330 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HH212_RS02340 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HH212_RS02350 ENOG4105D00 flagellar biosynthetic protein flhB HH212_RS02355 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HH212_RS02360 ENOG4105VS8 Flagellar biosynthetic protein fliq HH212_RS02365 ENOG4105CN7 Flagellar biosynthetic protein FliP HH212_RS02370 ENOG4105DD5 Flagellar motor switch protein HH212_RS02380 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HH212_RS02385 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HH212_RS02390 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HH212_RS02400 ENOG4108JIR Flagellum-specific ATP synthase HH212_RS02410 ENOG410804A Flagellar hook-associated 2 domain-containing protein HH212_RS02440 ENOG4107RD7 Flagellar Motor Protein, MotA HH212_RS02460 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HH212_RS02475 ENOG4108ZC9 flagellar basal-body rod protein flgc HH212_RS02485 ENOG4105BZE flagellar hook protein, FlgE HH212_RS02490 ENOG4108KPB Flagellar basal-body rod protein FlgF HH212_RS02495 ENOG4105CGA flagellar basal-body rod protein FlgG HH212_RS02500 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HH212_RS02505 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HH212_RS02515 ENOG4105E1Q flagellar hook-associated protein HH212_RS02520 ENOG4105DTJ flagellar hook-associated protein HH212_RS02530 ENOG4105CI3 gtp-binding protein typa HH212_RS02540 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HH212_RS02545 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HH212_RS02550 ENOG4105CHV Transcription elongation factor NusA HH212_RS02555 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HH212_RS02560 ENOG4105FE9 pseudouridine synthase HH212_RS02565 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HH212_RS02570 ENOG4105CHC glucokinase (EC 2.7.1.2) HH212_RS02600 ENOG4105D05 Receptor HH212_RS02605 ENOG4107RNH Outer membrane receptor FepA HH212_RS02610 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HH212_RS02615 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HH212_RS02635 ENOG4105DND Transcriptional regulator HH212_RS02655 ENOG4105D1U peptidase U62 modulator of DNA gyrase HH212_RS02670 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HH212_RS02675 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HH212_RS02685 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HH212_RS02690 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HH212_RS02700 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HH212_RS02710 ENOG4105D05 Receptor HH212_RS02715 ENOG4105DZ0 fad dependent oxidoreductase HH212_RS02720 ENOG4107AQZ Membrane HH212_RS02730 ENOG4107SCA Formamidase (EC 3.5.1.49) HH212_RS02735 ENOG4105D7N magnesium and cobalt transport protein CorA HH212_RS02740 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH212_RS02745 ENOG4105CUX Signal transduction histidine kinase HH212_RS02820 ENOG4108V1T peptidylprolyl cis-trans isomerase HH212_RS02845 ENOG4108Z4U Ferredoxin HH212_RS02850 ENOG4105CAY ferredoxin--nadp reductase HH212_RS02865 ENOG4108R3D Electron transport complex HH212_RS02870 ENOG4105CSM endonuclease III HH212_RS02910 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HH212_RS02920 ENOG4108RG3 short-chain dehydrogenase reductase HH212_RS02925 ENOG4105IQ5 FAD linked oxidase domain protein HH212_RS02945 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HH212_RS02955 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HH212_RS02960 ENOG4105K46 50S ribosomal protein l27 HH212_RS02965 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HH212_RS02970 ENOG4105EAH synthase HH212_RS02985 ENOG4105DU1 integral membrane protein, terc HH212_RS02995 ENOG4108IFG nitrite reductase, (NAD(P)H) HH212_RS03000 ENOG4107QZF nitrite reductase NADPH large subunit HH212_RS03005 ENOG4107QZF nitrite reductase NADPH large subunit HH212_RS03010 ENOG4107RNU major facilitator superfamily MFS_1 HH212_RS03015 ENOG4105I5W Transporter HH212_RS03045 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HH212_RS03065 ENOG4105D9R oxidoreductase HH212_RS03075 ENOG4105EDV vault protein HH212_RS03085 ENOG4105K6V RNA polymerase HH212_RS03090 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HH212_RS03095 ENOG4105CD3 dihydroorotase HH212_RS03100 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HH212_RS03105 ENOG4107SJI Dehydrogenase HH212_RS03110 ENOG4105BZ8 glutamate synthase HH212_RS03115 ENOG4105C26 Dehydrogenase HH212_RS03120 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HH212_RS03125 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HH212_RS03130 ENOG4108R86 Transcriptional regulator HH212_RS03135 ENOG4105KNA -acetyltransferase HH212_RS03160 ENOG4108HRK Histidine kinase HH212_RS03165 ENOG4108VAC response regulator HH212_RS03190 ENOG4105C26 Dehydrogenase HH212_RS03195 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HH212_RS03200 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HH212_RS03205 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HH212_RS03210 ENOG4105DD7 kinase (PfkB family HH212_RS03220 ENOG4105CN8 Transcriptional regulator HH212_RS03225 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HH212_RS03260 ENOG4105DIH basic membrane HH212_RS03265 ENOG4108JQ9 ABC transporter HH212_RS03270 ENOG4105UIB (ABC) transporter HH212_RS03290 ENOG4105CGH 5'-nucleotidase HH212_RS03305 ENOG4107QUY Guanine deaminase HH212_RS03315 ENOG4105C7W Xanthine dehydrogenase HH212_RS03330 ENOG4105VT2 5-hydroxyisourate hydrolase HH212_RS03345 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS03360 ENOG4107QHF type ii secretion system protein e HH212_RS03395 ENOG4105CS6 Rhs element vgr protein HH212_RS03400 ENOG4107FQ9 ethanolamine ammonia-lyase HH212_RS03405 ENOG4105CPD ethanolamine ammonia-lyase HH212_RS03425 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HH212_RS03435 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HH212_RS03440 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HH212_RS03465 ENOG4105BZU Histidine kinase HH212_RS03490 ENOG4105IPI Membrane HH212_RS03500 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HH212_RS03530 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HH212_RS03535 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HH212_RS03540 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HH212_RS03545 ENOG4105CPF Cell wall formation (By similarity) HH212_RS03550 ENOG4105DFU Cell wall formation (By similarity) HH212_RS03555 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HH212_RS03565 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HH212_RS03570 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HH212_RS03575 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HH212_RS03580 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HH212_RS03585 ENOG4105CJN penicillin-binding protein HH212_RS03590 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HH212_RS03595 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HH212_RS03600 ENOG4108V6E Cell division protein mraZ HH212_RS03640 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HH212_RS03670 ENOG4105CAK Cell division ATP-binding protein ftsE HH212_RS03675 ENOG4105CRP Part of the ABC transporter FtsEX involved in HH212_RS03680 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH212_RS03690 ENOG4108VHT MarR family transcriptional regulator HH212_RS03695 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH212_RS03705 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HH212_RS03735 ENOG41063Z6 transcriptional regulator, lysR family HH212_RS03740 ENOG4105C37 (CBS) domain HH212_RS03795 ENOG4108HRK Histidine kinase HH212_RS03800 ENOG4108NEV two component transcriptional regulator, LytTR family HH212_RS03805 ENOG4105IPI Membrane HH212_RS03815 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HH212_RS03820 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HH212_RS03840 ENOG4107QS1 Cytochrome C Oxidase, Subunit III HH212_RS03850 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) HH212_RS03860 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HH212_RS03865 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HH212_RS03870 ENOG4105MJ2 Competence protein HH212_RS03885 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HH212_RS03890 ENOG4105CZX twitching motility protein HH212_RS03900 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HH212_RS03905 ENOG4105NE1 Conserved Protein HH212_RS03920 ENOG4105II7 pyrroline-5-carboxylate reductase HH212_RS03925 ENOG4105DFA alanine racemase domain protein HH212_RS03930 ENOG4105CZX twitching motility protein HH212_RS03935 ENOG4105CZX twitching motility protein HH212_RS03940 ENOG4108V06 Glutathione peroxidase HH212_RS03945 ENOG4105DDI hemolysin-type calcium-binding region HH212_RS03950 ENOG4105CIR epoxide hydrolase HH212_RS03975 ENOG4105EMU Dehydrogenase HH212_RS03980 ENOG4105CF7 AraC family transcriptional regulator HH212_RS03985 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HH212_RS04005 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HH212_RS04010 ENOG4105EU8 FAD linked oxidase domain protein HH212_RS04015 ENOG4105CQB FAD linked oxidase domain protein HH212_RS04020 ENOG4108WBT adenosyltransferase HH212_RS04025 ENOG4107ZXI Rhomboid family HH212_RS04030 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HH212_RS04040 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HH212_RS04055 ENOG4105KHC sulfurtransferase HH212_RS04060 ENOG4105CNM Receptor HH212_RS04070 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HH212_RS04080 ENOG4105C2M dna polymerase I HH212_RS04090 ENOG4105CUV Homoserine Kinase HH212_RS04100 ENOG4105C4R Atp-dependent dna helicase HH212_RS04110 ENOG4105C9K Endothelin-converting enzyme 1 HH212_RS04120 ENOG4107QPD alcohol dehydrogenase HH212_RS04125 ENOG4105E3W Two component transcriptional regulator (Winged helix family HH212_RS04130 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HH212_RS04155 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HH212_RS04160 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HH212_RS04165 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HH212_RS04170 ENOG4105DC1 bifunctional purine biosynthesis protein purh HH212_RS04175 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) HH212_RS04180 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HH212_RS04185 ENOG4105CVJ phosphoglycerate mutase HH212_RS04190 ENOG4108V1U phospholipid-binding protein HH212_RS04195 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HH212_RS04220 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HH212_RS04230 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HH212_RS04235 ENOG4108UJD 30S ribosomal protein S9 HH212_RS04240 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HH212_RS04250 ENOG4108IUW ABC transporter HH212_RS04260 ENOG4108UKZ OsmC family HH212_RS04265 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) HH212_RS04275 ENOG4105DA5 (ABC) transporter HH212_RS04290 ENOG4105C9U ATP-dependent DNA helicase RecQ HH212_RS04295 ENOG4108RPN Protein smg homolog HH212_RS04300 ENOG4105C79 DNA protecting protein DprA HH212_RS04315 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HH212_RS04320 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HH212_RS04330 ENOG4105C3R Methionine synthase HH212_RS04345 ENOG4107RMN lycopene cyclase HH212_RS04350 ENOG4105EWK phytoene HH212_RS04360 ENOG4105IJY hydroxylase HH212_RS04370 ENOG4105ED2 Beta-lactamase HH212_RS04380 ENOG4105D58 Diguanylate phosphodiesterase HH212_RS04385 ENOG4105E7A Glutamine amidotransferase HH212_RS04400 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH212_RS04405 ENOG4105ES5 Histidine kinase HH212_RS04415 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HH212_RS04420 ENOG4105C75 arginyL-tRNA synthetase HH212_RS04435 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HH212_RS04440 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HH212_RS04450 ENOG4107VGR Catalase HH212_RS04470 ENOG41090KN UPF0303 protein HH212_RS04475 ENOG4105K6T rare lipoprotein A HH212_RS04480 ENOG4105CNI cell division protein FtsW HH212_RS04485 ENOG4105CJN penicillin-binding protein HH212_RS04510 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HH212_RS04515 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HH212_RS04520 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HH212_RS04525 ENOG4105CGK Exodeoxyribonuclease III HH212_RS04535 ENOG4105C34 Pseudouridine synthase HH212_RS04540 ENOG4108K0D peptidase, M48 HH212_RS04545 ENOG4105DWV Homoserine O-trans-acetylase HH212_RS04550 ENOG4105DWV Homoserine O-trans-acetylase HH212_RS04555 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HH212_RS04560 ENOG41080Z8 PHOSPHOCARRIER protein HH212_RS04570 ENOG4105D7Z glutathione synthase HH212_RS04585 ENOG4105BZU Histidine kinase HH212_RS04600 ENOG4105W0Z cytoplasmic protein HH212_RS04610 ENOG4105C0P Mg chelatase subunit ChlI HH212_RS04635 ENOG4105BZU Histidine kinase HH212_RS04670 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HH212_RS04675 ENOG4105EJC lysr family transcriptional regulator HH212_RS04720 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HH212_RS04725 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HH212_RS04735 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HH212_RS04745 ENOG4105E0A ABC, transporter HH212_RS04750 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HH212_RS04755 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HH212_RS04760 ENOG4108YZT Adenosylcobinamide kinase HH212_RS04765 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HH212_RS04770 ENOG4105EFT decarboxylase HH212_RS04775 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HH212_RS04780 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HH212_RS04825 ENOG4107RZC phospholipase d HH212_RS04840 ENOG4105CA3 membrane-bound lytic murein transglycosylase HH212_RS04850 ENOG4105NWN ApaG protein HH212_RS04855 ENOG4105DJV ribulose-phosphate 3-epimerase HH212_RS04860 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HH212_RS04870 ENOG4105DDQ anthranilate synthase HH212_RS04875 ENOG4107QYG anthranilate phosphoribosyltransferase HH212_RS04880 ENOG4105DK0 Indole-3-glycerol phosphate synthase HH212_RS04900 ENOG4105T95 Thiol disulfide interChange protein HH212_RS04905 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HH212_RS04935 ENOG4105C0D helicase HH212_RS04945 ENOG4105E2A Dehydrogenase HH212_RS04955 ENOG41062D9 Histidine kinase HH212_RS04975 ENOG4105C9K Endothelin-converting enzyme 1 HH212_RS04980 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HH212_RS04985 ENOG4105K4I Scp-like extracellular HH212_RS04990 ENOG4108ZHJ Organic hydroperoxide resistance protein HH212_RS04995 ENOG4108ESY Metal dependent phosphohydrolase HH212_RS05005 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HH212_RS05010 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS05015 ENOG4108S4H thioesterase Superfamily protein HH212_RS05060 ENOG4109066 lysm domain bon superfamily protein HH212_RS05080 ENOG4105D7B Flagellar biosynthesis protein flha HH212_RS05085 ENOG4105D00 flagellar biosynthetic protein flhB HH212_RS05090 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HH212_RS05095 ENOG4105VS8 Flagellar biosynthetic protein fliq HH212_RS05115 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH212_RS05120 ENOG4105CN7 Flagellar biosynthetic protein FliP HH212_RS05130 ENOG4105DD5 Flagellar motor switch protein HH212_RS05140 ENOG4105BZE flagellar hook protein, FlgE HH212_RS05145 ENOG410822I Flagellar hook capping protein HH212_RS05175 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HH212_RS05180 ENOG41084DA flagellar hook-basal body complex protein fliE HH212_RS05190 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HH212_RS05195 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HH212_RS05200 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HH212_RS05210 ENOG4105CGA flagellar basal-body rod protein FlgG HH212_RS05215 ENOG4105CGA flagellar basal-body rod protein FlgG HH212_RS05225 ENOG4105BZU Histidine kinase HH212_RS05230 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HH212_RS05235 ENOG4107RCI amp-dependent synthetase and ligase HH212_RS05250 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH212_RS05255 ENOG4105CBN LysR family transcriptional regulator HH212_RS05260 ENOG4105QNF Outer membrane lipoprotein HH212_RS05270 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HH212_RS05285 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HH212_RS05310 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS05315 ENOG4105E5J UV damage endonuclease HH212_RS05320 ENOG4105CPC Aldo Keto reductase HH212_RS05325 ENOG4105FFC UPF0187 protein HH212_RS05340 ENOG4105DEN Luciferase family HH212_RS05350 ENOG4105D3W isochorismatase HH212_RS05365 ENOG4105EAQ (twin-arginine translocation) pathway signal HH212_RS05400 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HH212_RS05410 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HH212_RS05415 ENOG4105BZU Histidine kinase HH212_RS05435 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HH212_RS05440 ENOG4105CFU surface antigen HH212_RS05500 ENOG4105EU0 Major facilitator Superfamily HH212_RS05620 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HH212_RS05625 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS05635 ENOG4105BZ9 Cytochrome C oxidase, subunit I HH212_RS05640 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HH212_RS05670 ENOG4105CN1 protease HH212_RS05685 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HH212_RS05690 ENOG4105CPK Glycosyl transferase (Group 1 HH212_RS05695 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HH212_RS05700 ENOG4105E39 Enoyl-CoA hydratase HH212_RS05705 ENOG4105CHU acetyl-coa acetyltransferase HH212_RS05715 ENOG4105CSU acyl-Coa dehydrogenase HH212_RS05725 ENOG4105VEJ Heat shock protein HH212_RS05730 ENOG4105DZQ phospholipase D Transphosphatidylase HH212_RS05735 ENOG4105X23 Endonuclease Exonuclease phosphatase HH212_RS05745 ENOG4105E2Y ABC, transporter HH212_RS05750 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HH212_RS05755 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HH212_RS05760 ENOG4105GVF (ABC) transporter HH212_RS05770 ENOG4106TD9 Diguanylate cyclase HH212_RS05775 ENOG4108TIT dATP pyrophosphohydrolase HH212_RS05780 ENOG4105C9M aspartyl-trna synthetase HH212_RS05800 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HH212_RS05815 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HH212_RS05825 ENOG4105VEQ Cold shock protein HH212_RS05845 ENOG4105W39 Membrane HH212_RS05850 ENOG4105C7B Threonine dehydratase HH212_RS05855 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HH212_RS05860 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HH212_RS05865 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HH212_RS05870 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HH212_RS05880 ENOG4105E39 Enoyl-CoA hydratase HH212_RS05885 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HH212_RS05890 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH212_RS05895 ENOG4108IUZ ABC transporter HH212_RS05910 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HH212_RS05915 ENOG4105C2X Arabinose 5-phosphate isomerase HH212_RS05925 ENOG4105BZU Histidine kinase HH212_RS05940 ENOG4105QVC MOSC domain-containing protein HH212_RS05945 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HH212_RS05955 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HH212_RS05960 ENOG4105DWF phosphomethylpyrimidine kinase HH212_RS05965 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HH212_RS05980 ENOG4105CXN decarboxylase HH212_RS06015 ENOG4105C3G gtp-binding protein HH212_RS06035 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HH212_RS06040 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HH212_RS06045 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HH212_RS06050 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HH212_RS06060 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HH212_RS06070 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein HH212_RS06075 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HH212_RS06085 ENOG4105CEN a g-specific adenine glycosylase HH212_RS06100 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HH212_RS06115 ENOG4105E4G Type IV pilus HH212_RS06140 ENOG4108JQC penicillin-binding protein 1A HH212_RS06145 ENOG4105XQ6 frataxin-like protein HH212_RS06155 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HH212_RS06165 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HH212_RS06170 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HH212_RS06175 ENOG4105CRE cytochrome C HH212_RS06185 ENOG4106RE7 Cytochrome HH212_RS06195 ENOG4105D52 delta-aminolevulinic acid dehydratase HH212_RS06210 ENOG4105ENT Efflux transporter rnd family, mfp subunit HH212_RS06215 ENOG4105E0F Histidine kinase HH212_RS06230 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HH212_RS06235 ENOG4108ZT0 50S ribosomal protein l17 HH212_RS06240 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HH212_RS06245 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HH212_RS06250 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HH212_RS06255 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HH212_RS06260 ENOG41067V7 50S ribosomal protein L36 HH212_RS06265 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HH212_RS06270 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HH212_RS06275 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HH212_RS06280 ENOG4105VPB 50S ribosomal protein L30 HH212_RS06285 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HH212_RS06290 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HH212_RS06295 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HH212_RS06300 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HH212_RS06305 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HH212_RS06310 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HH212_RS06315 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HH212_RS06320 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HH212_RS06325 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HH212_RS06330 ENOG41084PQ 50s ribosomal protein l29 HH212_RS06335 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HH212_RS06340 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HH212_RS06345 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HH212_RS06350 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HH212_RS06355 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HH212_RS06360 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HH212_RS06365 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HH212_RS06370 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HH212_RS06380 ENOG4105D64 Mechanosensitive ion channel HH212_RS06385 ENOG4105ETE Transcriptional regulator (LacI family HH212_RS06395 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HH212_RS06405 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HH212_RS06410 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HH212_RS06415 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HH212_RS06420 ENOG4105DIJ Phosphoethanolamine transferase HH212_RS06425 ENOG4108V1U phospholipid-binding protein HH212_RS06440 ENOG4105C19 ABC transporter HH212_RS06445 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HH212_RS06450 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HH212_RS06460 ENOG4105BZU Histidine kinase HH212_RS06465 ENOG4105C7W Xanthine dehydrogenase HH212_RS06470 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HH212_RS06475 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HH212_RS06480 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HH212_RS06510 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HH212_RS06520 ENOG4105CMS peptidase U62, modulator of DNA gyrase HH212_RS06530 ENOG4105CMS peptidase U62, modulator of DNA gyrase HH212_RS06550 ENOG41089UC methyltransferase, type 11 HH212_RS06555 ENOG4108KSB HipA-like N-terminal domain HH212_RS06565 ENOG41066YJ Beta-lactamase HH212_RS06580 ENOG4108NVI HH212_RS06585 ENOG4105E2V Glycosyltransferase 36 HH212_RS06590 ENOG4105C3J Cysteine desulfurase HH212_RS06595 ENOG4108XM1 transcriptional regulator AsnC family HH212_RS06620 ENOG4105BZU Histidine kinase HH212_RS06630 ENOG4107YTP response regulator receiver protein HH212_RS06650 ENOG4105BZU Histidine kinase HH212_RS06655 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HH212_RS06660 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HH212_RS06665 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HH212_RS06675 ENOG4108VZM 50s ribosomal protein L10 HH212_RS06680 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HH212_RS06685 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HH212_RS06730 ENOG4108VYJ response regulator receiver protein HH212_RS06735 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HH212_RS06745 ENOG4105CHR reductase HH212_RS06755 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HH212_RS06790 ENOG4108XM1 transcriptional regulator AsnC family HH212_RS06795 ENOG4108PC0 lipolytic protein G-D-S-L family HH212_RS06800 ENOG4105EX0 alpha-galactosidase HH212_RS06820 ENOG4105ETE Transcriptional regulator (LacI family HH212_RS06830 ENOG4105D7K pfkb domain protein HH212_RS06840 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HH212_RS06850 ENOG4105CMR udp-glucose 4-epimerase HH212_RS06855 ENOG4107SC1 transglycosylase HH212_RS06865 ENOG4105SYT Methylenetetrahydrofolate reductase HH212_RS06870 ENOG41082T9 Membrane HH212_RS06875 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HH212_RS06880 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HH212_RS06890 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HH212_RS06895 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HH212_RS06905 ENOG4108Z9W Outer membrane porin HH212_RS06915 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH212_RS06920 ENOG4105CKI cobalamin synthesis protein HH212_RS06935 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HH212_RS06940 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HH212_RS06960 ENOG4105D7Q type ii secretion system HH212_RS06965 ENOG4107QHF type ii secretion system protein e HH212_RS06970 ENOG4105GVR general secretion pathway protein D HH212_RS07005 ENOG4105VWV general secretion pathway protein h HH212_RS07010 ENOG4108VAU general secretion pathway protein G HH212_RS07015 ENOG4105D06 uba thif-type nad fad binding protein HH212_RS07020 ENOG4105CN1 protease HH212_RS07025 ENOG41063SB peptidase HH212_RS07030 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HH212_RS07035 ENOG4107YZP Rhodanese domain protein HH212_RS07040 ENOG4105VW4 glutaredoxin 3 HH212_RS07045 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HH212_RS07070 ENOG4105C0H protease HH212_RS07075 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HH212_RS07080 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HH212_RS07085 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HH212_RS07090 ENOG4105EIX cytochrome c1 HH212_RS07095 ENOG4107MKT Stringent starvation protein a HH212_RS07100 ENOG4105KB2 stringent starvation protein b HH212_RS07155 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP HH212_RS07245 ENOG4105W1Y Transcriptional regulator HH212_RS07250 ENOG4105CAU Arsenical resistance protein, ArsH HH212_RS07260 ENOG4107R5R arsenical pump membrane protein HH212_RS07265 ENOG4107WAU Protein tyrosine phosphatase HH212_RS07275 ENOG4105E0C molybdate abc transporter HH212_RS07300 ENOG4105ESI atpase involved in dna repair HH212_RS07315 ENOG4105CYB regulatoR HH212_RS07390 ENOG4105BZU Histidine kinase HH212_RS07400 ENOG4105C4M (Ubiquinol oxidase) subunit I HH212_RS07405 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HH212_RS07415 ENOG4105D5P Methylmalonyl-coA mutase HH212_RS07435 ENOG4105CUZ uba thif-type nad fad binding protein HH212_RS07495 ENOG4108QV3 biosynthesis protein HH212_RS07530 ENOG4107TYR Glycosyl Transferase HH212_RS07540 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HH212_RS07545 ENOG4105CND Glycosyl transferase, family 2 HH212_RS07560 ENOG4105CEY Amp-dependent synthetase and ligase HH212_RS07600 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH212_RS07620 ENOG4105MPD Cytochrome HH212_RS07630 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 HH212_RS07645 ENOG4105C9K Endothelin-converting enzyme 1 HH212_RS07650 ENOG4105C9K Endothelin-converting enzyme 1 HH212_RS07670 ENOG4105C6Y Udp-glucose 6-dehydrogenase HH212_RS07675 ENOG4105CN1 protease HH212_RS07725 ENOG4105CHR reductase HH212_RS07730 ENOG4105CHU acetyl-coa acetyltransferase HH212_RS07735 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HH212_RS07740 ENOG4107QMS site-determining protein HH212_RS07745 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HH212_RS07760 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HH212_RS07765 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HH212_RS07770 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HH212_RS07775 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HH212_RS07785 ENOG4105D9M gamma-glutamylcysteine synthetase HH212_RS07790 ENOG41067B5 Histone deacetylase superfamily protein HH212_RS07800 ENOG4105CSH Transporter HH212_RS07810 ENOG4105BZU Histidine kinase HH212_RS07820 ENOG4108V1T peptidylprolyl cis-trans isomerase HH212_RS07825 ENOG4105DFH Transport of potassium into the cell (By similarity) HH212_RS07835 ENOG4105C5H ABC transporter HH212_RS07885 ENOG4105DC7 peptidase M24 HH212_RS07890 ENOG4108UGV hypoxanthine phosphoribosyltransferase HH212_RS07920 ENOG4105CAS nag kinase HH212_RS07940 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HH212_RS07960 ENOG4105CSR polyphosphate kinase 2 HH212_RS07965 ENOG4105K4P CoA-binding domain protein HH212_RS07970 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HH212_RS07975 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HH212_RS07980 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HH212_RS07985 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HH212_RS07990 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HH212_RS07995 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HH212_RS08000 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HH212_RS08005 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) HH212_RS08020 ENOG4105FA0 parb-like partition protein HH212_RS08025 ENOG4107QJE Chromosome Partitioning Protein HH212_RS08030 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HH212_RS08035 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HH212_RS08045 ENOG4105D74 hydrolase HH212_RS08050 ENOG4108HWW ABC transporter HH212_RS08055 ENOG4105C32 Amino acid ABC transporter (Permease) HH212_RS08065 ENOG4108IV0 ABC, transporter HH212_RS08070 ENOG4105C0Z ABC transporter HH212_RS08085 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HH212_RS08090 ENOG4105DCF alanine dehydrogenase HH212_RS08095 ENOG4105C26 Dehydrogenase HH212_RS08105 ENOG4105EW9 transcriptional regulator AsnC family HH212_RS08130 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HH212_RS08135 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HH212_RS08140 ENOG4106H78 methyltransferase HH212_RS08150 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HH212_RS08155 ENOG4105FKN transcriptional regulator, AsnC family HH212_RS08165 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HH212_RS08290 ENOG4105E9K Isocitrate dehydrogenase HH212_RS08325 ENOG4108SKZ Patatin-like phospholipase HH212_RS08335 ENOG4105F4R Transcriptional regulator mode HH212_RS08340 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HH212_RS08345 ENOG4105E0C molybdate abc transporter HH212_RS08350 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HH212_RS08370 ENOG4105DQ4 alcohol dehydrogenase HH212_RS08390 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HH212_RS08400 ENOG4105CKW Inner membrane protein yedI HH212_RS08410 ENOG4105K70 DNA-binding protein HH212_RS08415 ENOG410829K Lysine exporter protein (Lyse ygga) HH212_RS08430 ENOG4105VT3 DNA binding domain protein, excisionase family HH212_RS08435 ENOG4108Z43 UPF0250 protein HH212_RS08440 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HH212_RS08445 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HH212_RS08455 ENOG4108IEG Formate dehydrogenase Alpha subunit HH212_RS08470 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HH212_RS08490 ENOG4105W4M Transport-associated protein HH212_RS08495 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HH212_RS08500 ENOG41082RQ UPF0102 protein HH212_RS08505 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HH212_RS08520 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HH212_RS08525 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HH212_RS08535 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HH212_RS08540 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HH212_RS08545 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HH212_RS08555 ENOG4108IPT Naphthoate synthase HH212_RS08560 ENOG4107QX3 carboxylase HH212_RS08570 ENOG4105MWK D-amino acid dehydrogenase, small subunit HH212_RS08575 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HH212_RS08585 ENOG4105F32 YngK protein HH212_RS08595 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HH212_RS08605 ENOG4108UQS dipeptidase HH212_RS08615 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HH212_RS08620 ENOG4108JIC nucleoside recognition domain protein HH212_RS08625 ENOG4105DEF Extracellular solute-binding protein, family 5 HH212_RS08635 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HH212_RS08655 ENOG4105C1G acyl-Coa dehydrogenase HH212_RS08660 ENOG4105CHR reductase HH212_RS08670 ENOG4105C1G acyl-Coa dehydrogenase HH212_RS08675 ENOG4105W1Y Transcriptional regulator HH212_RS08710 ENOG4105BZM domain protein HH212_RS08715 ENOG4105C0D helicase HH212_RS08725 ENOG4105XJC Two component transcriptional regulator (Winged helix family HH212_RS08760 ENOG4105DHJ ABC, transporter HH212_RS08765 ENOG4105CY3 ABC transporter, permease HH212_RS08770 ENOG4107PE3 Mammalian cell entry related domain protein HH212_RS08790 ENOG4105DA5 (ABC) transporter HH212_RS08795 ENOG4105E3A (ABC) transporter HH212_RS08805 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HH212_RS08810 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HH212_RS08830 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HH212_RS08840 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HH212_RS08845 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HH212_RS08850 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HH212_RS08855 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase HH212_RS08860 ENOG4105K59 histidine triad (HIT) protein HH212_RS08865 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HH212_RS08870 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HH212_RS08875 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HH212_RS08890 ENOG4105C0D helicase HH212_RS08900 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HH212_RS08905 ENOG4105C25 Primosomal protein n' HH212_RS08965 ENOG4105CHB tonB-dependent Receptor HH212_RS08970 ENOG4105C26 Dehydrogenase HH212_RS08975 ENOG4105DZG Dehydrogenase HH212_RS08980 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HH212_RS09015 ENOG4105C4R Atp-dependent dna helicase HH212_RS09045 ENOG4105DGW oligopeptidase A HH212_RS09050 ENOG4105DGW oligopeptidase A HH212_RS09055 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HH212_RS09065 ENOG4105CCT upf0313 protein HH212_RS09075 ENOG4105EYW Ion transport protein HH212_RS09080 ENOG4105BZU Histidine kinase HH212_RS09100 ENOG4107ZSV Receptor HH212_RS09105 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HH212_RS09110 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HH212_RS09115 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HH212_RS09120 ENOG4105DH7 May be involved in recombination (By similarity) HH212_RS09145 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HH212_RS09150 ENOG4105CH6 catalase HH212_RS09170 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HH212_RS09195 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HH212_RS09205 ENOG4105KCV RNA signal recognition particle 4.5S RNA HH212_RS09210 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HH212_RS09225 ENOG4108JJB ABC transporter HH212_RS09230 ENOG4105CIA precorrin-4 C(11)-methyltransferase HH212_RS09235 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HH212_RS09240 ENOG41081F0 Precorrin-8x methylmutase HH212_RS09245 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HH212_RS09250 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HH212_RS09260 ENOG4108P62 biosynthesis protein (CbiG) HH212_RS09270 ENOG4105E4R Precorrin-3B C17-methyltransferase HH212_RS09275 ENOG4105NZG Ferredoxin HH212_RS09300 ENOG4105DDI hemolysin-type calcium-binding region HH212_RS09305 ENOG4105C6Z Gluconate HH212_RS09315 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HH212_RS09330 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS09360 ENOG4105E09 nadh pyrophosphatase HH212_RS09370 ENOG4105EUJ GTP cyclohydrolase i HH212_RS09380 ENOG4108FN7 Aldo keto reductase HH212_RS09390 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HH212_RS09395 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HH212_RS09400 ENOG4105C7W Xanthine dehydrogenase HH212_RS09410 ENOG4105Y49 secretion protein, HlyD family HH212_RS09415 ENOG4105ZQC membrane protein AaeX HH212_RS09420 ENOG4105DSW Fusaric acid resistance protein HH212_RS09430 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HH212_RS09435 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HH212_RS09450 ENOG4108WC9 type VI secretion system effector, hcp1 family HH212_RS09485 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HH212_RS09490 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HH212_RS09495 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HH212_RS09500 ENOG4105VG0 50S ribosomal protein l34 HH212_RS09505 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HH212_RS09510 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HH212_RS09515 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HH212_RS09520 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HH212_RS09525 ENOG4105CBN LysR family transcriptional regulator HH212_RS09530 ENOG4105CHR reductase HH212_RS09555 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HH212_RS09565 ENOG4107RGM aldo keto reductase HH212_RS09570 ENOG4105DZ1 carboxypeptidase HH212_RS09575 ENOG4105DHZ alpha beta HH212_RS09600 ENOG4105DHJ ABC, transporter HH212_RS09640 ENOG4105C7W Xanthine dehydrogenase HH212_RS09645 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HH212_RS09650 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HH212_RS09655 ENOG4107QPD alcohol dehydrogenase HH212_RS09670 ENOG4105DZG Dehydrogenase HH212_RS09675 ENOG4105WJN methanol dehydrogenase-like protein, cytochrome cL (XoxG) HH212_RS09705 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HH212_RS09735 ENOG4107SQI penicillin amidase HH212_RS09740 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH212_RS09745 ENOG41061N2 exported protein HH212_RS09750 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HH212_RS09760 ENOG4105CH2 amidohydrolase HH212_RS09765 ENOG4108J2R molybdopterin oxidoreductase HH212_RS09775 ENOG4105CEY Amp-dependent synthetase and ligase HH212_RS09780 ENOG4105CEY Amp-dependent synthetase and ligase HH212_RS09790 ENOG4105DGI Alkaline phosphatase HH212_RS09795 ENOG4105NAU thioesterase Superfamily protein HH212_RS09800 ENOG4108JJ7 ABC transporter HH212_RS09815 ENOG4105CK2 sodium dicarboxylate symporter HH212_RS09820 ENOG4105CDA abc transporter atp-binding protein HH212_RS09840 ENOG4105EKE dihydroorotase HH212_RS09890 ENOG4105CNA YD repeat protein HH212_RS09900 ENOG4105CS6 Rhs element vgr protein HH212_RS09920 ENOG4105CB5 ATP-dependent DNA helicase recG HH212_RS09925 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HH212_RS09930 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HH212_RS09935 ENOG4105VIE preprotein translocase, subunit YajC HH212_RS09940 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HH212_RS09945 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HH212_RS09965 ENOG4105ECQ AraC Family Transcriptional Regulator HH212_RS09970 ENOG4105C8Y Acetylornithine aminotransferase HH212_RS09975 ENOG4108T2Z Arginine HH212_RS09985 ENOG4105C26 Dehydrogenase HH212_RS09990 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HH212_RS09995 ENOG4105C7I Dehydrogenase HH212_RS10000 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HH212_RS10015 ENOG4105CXK mandelate racemase muconate lactonizing HH212_RS10020 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH212_RS10035 ENOG41081JD Transcriptional regulator HH212_RS10040 ENOG4105CUB amino acid HH212_RS10045 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH212_RS10055 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HH212_RS10060 ENOG4105Y3U Transglycosylase-associated protein HH212_RS10075 ENOG4108YYC ycei family HH212_RS10090 ENOG4107QTF adenylosuccinate lyase HH212_RS10095 ENOG4108U78 Glutathione S-transferase HH212_RS10100 ENOG4105ETE Transcriptional regulator (LacI family HH212_RS10110 ENOG4107QW3 Sucrose phosphorylase HH212_RS10130 ENOG4108UQY Iron-storage protein HH212_RS10150 ENOG4105CE1 Ferrous iron transport protein b HH212_RS10175 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS10185 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HH212_RS10200 ENOG4108NJZ Sensory box GGDEF EAL domain protein HH212_RS10205 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HH212_RS10210 ENOG41062IR nudix hydrolase HH212_RS10215 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HH212_RS10220 ENOG4105W8H transhydrogenase (subunit alpha HH212_RS10225 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HH212_RS10230 ENOG4105D0A hydroxylase HH212_RS10235 ENOG4107RAQ aminopeptidase HH212_RS10240 ENOG4108S0S Nucleotidyl transferase HH212_RS10245 ENOG4105EHM Aminoglycoside phosphotransferase HH212_RS10250 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HH212_RS10255 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HH212_RS10260 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HH212_RS10265 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HH212_RS10300 ENOG41090R7 Ferric uptake HH212_RS10305 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HH212_RS10310 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HH212_RS10320 ENOG4105C8T Leucyl-tRNA synthetase HH212_RS10335 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HH212_RS10340 ENOG4108YXA Membrane HH212_RS10345 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HH212_RS10350 ENOG4105C2C drug resistance transporter, Bcr CflA HH212_RS10370 ENOG4105CUX Signal transduction histidine kinase HH212_RS10375 ENOG4105BZU Histidine kinase HH212_RS10395 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HH212_RS10410 ENOG4105D7W serine acetyltransferase HH212_RS10440 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HH212_RS10445 ENOG4105C9U ATP-dependent DNA helicase RecQ HH212_RS10450 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HH212_RS10455 ENOG4105KRS Proteinase inhibitor HH212_RS10465 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HH212_RS10470 ENOG41082J7 Rhodanese domain protein HH212_RS10475 ENOG4105DFG type I secretion outer membrane protein HH212_RS10480 ENOG4107RDF Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HH212_RS10485 ENOG4108UYE Lactoylglutathione lyase HH212_RS10490 ENOG4108Z9K Osmotically inducible protein HH212_RS10510 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HH212_RS10515 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HH212_RS10520 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HH212_RS10530 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HH212_RS10535 ENOG4105CFG Acts as a chaperone (By similarity) HH212_RS10540 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HH212_RS10545 ENOG41077A9 carbonic anhydrase HH212_RS10560 ENOG4105C26 Dehydrogenase HH212_RS10565 ENOG4108Z86 Glutamine amidotransferase HH212_RS10570 ENOG4105CFQ glutamine synthetase HH212_RS10575 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HH212_RS10585 ENOG4108VAC response regulator HH212_RS10590 ENOG4108HRK Histidine kinase HH212_RS10605 ENOG4106UW1 Major Facilitator superfamily HH212_RS10615 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HH212_RS10625 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HH212_RS10630 ENOG4105DJ0 Poly(A) Polymerase HH212_RS10640 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HH212_RS10655 ENOG4107QN1 sodium solute HH212_RS10665 ENOG4105DHQ Histidine kinase HH212_RS10675 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HH212_RS10680 ENOG4108004 Modulates RecA activity (By similarity) HH212_RS10690 ENOG4105CMV Succinyl-CoA synthetase subunit beta HH212_RS10695 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HH212_RS10700 ENOG4105KHS type IV fimbrial pilin protein HH212_RS10710 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HH212_RS10715 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS10720 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HH212_RS10725 ENOG4105ERG peptidase m48, ste24p HH212_RS10735 ENOG4105DNZ Alpha Beta Hydrolase HH212_RS10755 ENOG4105BZA Phosphoglycerate kinase HH212_RS10760 ENOG4105CA9 Pyruvate kinase HH212_RS10770 ENOG4105C8V SAICAR synthetase HH212_RS10775 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HH212_RS10780 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HH212_RS10785 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HH212_RS10805 ENOG4105C1G acyl-Coa dehydrogenase HH212_RS10815 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HH212_RS10820 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HH212_RS10825 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HH212_RS10830 ENOG4105CUZ uba thif-type nad fad binding protein HH212_RS10845 ENOG4105PGM cation diffusion facilitator family transporter HH212_RS10855 ENOG4107RAN Peptidase, M16 HH212_RS10870 ENOG4107TH8 cina domain protein HH212_RS10875 ENOG4105BZU Histidine kinase HH212_RS10880 ENOG4105BZU Histidine kinase HH212_RS10885 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HH212_RS10900 ENOG4105C6K Malic enzyme HH212_RS10905 ENOG4105C0K Gdp-mannose 4,6-dehydratase HH212_RS10925 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HH212_RS10930 ENOG4105BZU Histidine kinase HH212_RS10975 ENOG4105C0D helicase HH212_RS10980 ENOG4108I5C dEAD DEAH box helicase HH212_RS11020 ENOG4105MN3 Resolvase HH212_RS11070 ENOG4105NRA 50s ribosomal protein l31 type b HH212_RS11075 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HH212_RS11085 ENOG4105CZE histidine utilization repressor HH212_RS11090 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HH212_RS11100 ENOG4105EFZ amidohydrolase HH212_RS11105 ENOG4105CGP Urocanate hydratase HH212_RS11110 ENOG4105C84 Histidine ammonia-lyase HH212_RS11120 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HH212_RS11125 ENOG41090B9 response to stress HH212_RS11130 ENOG4105CI2 imidazolone-5-propionate hydrolase HH212_RS11135 ENOG4105R40 Glycine betaine carnitine choline HH212_RS11175 ENOG4105C1P efflux transporter, rnd family, mfp subunit HH212_RS11185 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH212_RS11200 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HH212_RS11215 ENOG4108VX5 3-methyladenine DNA glycosylase HH212_RS11235 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS11245 ENOG4105CNT hydrolase family 2 HH212_RS11250 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HH212_RS11260 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH212_RS11270 ENOG4106CJB Phospholipase Carboxylesterase HH212_RS11275 ENOG4108RIR Molybdenum cofactor biosynthesis protein HH212_RS11285 ENOG4105CMS peptidase U62, modulator of DNA gyrase HH212_RS11290 ENOG4108Z9W Outer membrane porin HH212_RS11295 ENOG4108RCM Nitroreductase HH212_RS11310 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HH212_RS11315 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HH212_RS11320 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HH212_RS11325 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HH212_RS11330 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HH212_RS11335 ENOG4108UKI Enoyl-CoA hydratase HH212_RS11340 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HH212_RS11345 ENOG4108ZJI phenylacetic acid degradation protein HH212_RS11355 ENOG4105CHU acetyl-coa acetyltransferase HH212_RS11360 ENOG4108Z0R Transferase HH212_RS11365 ENOG4105DXM phenylacetic acid degradation protein HH212_RS11380 ENOG4107VXZ Hydrolase HH212_RS11385 ENOG4105CH7 arginosuccinase HH212_RS11415 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HH212_RS11420 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HH212_RS11425 ENOG4108Z86 Glutamine amidotransferase HH212_RS11460 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HH212_RS11470 ENOG4106RE7 Cytochrome HH212_RS11475 ENOG4105CHH sulfate transporter HH212_RS11490 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HH212_RS11495 ENOG4105E4C Lytic transglycosylase catalytic HH212_RS11500 ENOG4108W5M transcriptional regulator HH212_RS11515 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HH212_RS11520 ENOG4107Z6I Thiamine biosynthesis protein HH212_RS11525 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HH212_RS11545 ENOG4107TUY Histidine kinase HH212_RS11550 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH212_RS11555 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HH212_RS11560 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HH212_RS11565 ENOG4105E2K Glycosyl transferase (Group 1 HH212_RS11570 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HH212_RS11585 ENOG4108VIA integral membrane protein HH212_RS11590 ENOG4107T4Z adenosine kinase HH212_RS11605 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HH212_RS11610 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HH212_RS11615 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HH212_RS11620 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HH212_RS11625 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HH212_RS11635 ENOG4105DFU Cell wall formation (By similarity) HH212_RS11640 ENOG4105IPS esterase HH212_RS11645 ENOG410807V Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HH212_RS11660 ENOG4105E2X shikimate dehydrogenase HH212_RS11665 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HH212_RS11675 ENOG4105CNM Receptor HH212_RS11685 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HH212_RS11695 ENOG4105VCQ rubredoxin HH212_RS11700 ENOG4108UNF response regulator HH212_RS11705 ENOG4105M3Z response regulator HH212_RS11715 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS11735 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HH212_RS11740 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HH212_RS11745 ENOG4105CXT aspartate transcarbamylase HH212_RS11750 ENOG4105CD3 dihydroorotase HH212_RS11755 ENOG4108Z20 Acyl-transferase HH212_RS11760 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HH212_RS11775 ENOG4107QKV phosphomannomutase HH212_RS11780 ENOG4105D16 lipopolysaccharide heptosyltransferase i HH212_RS11805 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HH212_RS11810 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HH212_RS11815 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HH212_RS11820 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HH212_RS11825 ENOG4108JU5 Magnesium and cobalt efflux protein HH212_RS11830 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HH212_RS11835 ENOG4105C9A Phoh family HH212_RS11840 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HH212_RS11860 ENOG4108K3A Glutathione S-transferase HH212_RS11880 ENOG4105CKD glutathione-regulated potassium-efflux system protein HH212_RS11885 ENOG4106BRA Membrane HH212_RS11895 ENOG4105CMJ mandelate racemase muconate lactonizing HH212_RS11900 ENOG4105EJC lysr family transcriptional regulator HH212_RS11910 ENOG4105CN9 Peptidase m42 family protein HH212_RS11925 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HH212_RS11930 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HH212_RS11940 ENOG4105DQR SNARE associated Golgi HH212_RS11955 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HH212_RS11960 ENOG4105K8N protein family UPF0079, ATPase HH212_RS11965 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HH212_RS11975 ENOG4108ZXC Two component transcriptional regulator, luxr family HH212_RS11980 ENOG4105BZU Histidine kinase HH212_RS11985 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HH212_RS11995 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH212_RS12010 ENOG4108Z66 YbaK ebsC protein HH212_RS12015 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HH212_RS12075 ENOG4105CNU cell division protein FtsK HH212_RS12080 ENOG4105CFI type iii restriction protein res subunit HH212_RS12110 ENOG41082BM Transcriptional regulator, arsr family HH212_RS12140 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HH212_RS12145 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HH212_RS12150 ENOG4108MTB glycosyl transferase family HH212_RS12155 ENOG4105CBX hi0933 family HH212_RS12160 ENOG4105VCC 30S ribosomal protein S21 HH212_RS12170 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HH212_RS12200 ENOG4105CS6 Rhs element vgr protein HH212_RS12275 ENOG4105C1J atp-dependent rna helicase HH212_RS12295 ENOG4105EY8 ABC transporter HH212_RS12305 ENOG4105IJJ transcriptional regulator, crp fnr family HH212_RS12315 ENOG4108T5G Adenylate HH212_RS12330 ENOG4108JJ6 Type I secretion system ATPase HH212_RS12335 ENOG4107QZV Type I secretion membrane fusion protein HH212_RS12340 ENOG4105DFG type I secretion outer membrane protein HH212_RS12345 ENOG4105C72 UPF0176 protein HH212_RS12370 ENOG4105BZ1 (ABC) transporter HH212_RS12375 ENOG4105XA0 heptosyltransferase ii HH212_RS12390 ENOG4105CEY Amp-dependent synthetase and ligase HH212_RS12400 ENOG4105C03 ribonuclease HH212_RS12405 ENOG4108Z03 MAF-like protein HH212_RS12410 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HH212_RS12415 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HH212_RS12420 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HH212_RS12425 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HH212_RS12430 ENOG4105CNM Receptor HH212_RS12440 ENOG4105C12 Phosphoribosylglycinamide synthetase HH212_RS12445 ENOG4105CDY transcriptional regulatory protein HH212_RS12455 ENOG4108Z5K methylglyoxal synthase HH212_RS12460 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HH212_RS12475 ENOG4105CD8 aminopeptidase N HH212_RS12480 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HH212_RS12515 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS12565 ENOG4105BZU Histidine kinase HH212_RS12650 ENOG4105CS6 Rhs element vgr protein HH212_RS12655 ENOG4105BZU Histidine kinase HH212_RS12660 ENOG4105BZ1 (ABC) transporter HH212_RS12665 ENOG4105BZ1 (ABC) transporter HH212_RS12675 ENOG4105DZC cytosine deaminase HH212_RS12685 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS12695 ENOG4108IUK alpha amylase, catalytic HH212_RS12705 ENOG4105QV4 Tryptophan halogenase HH212_RS12720 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HH212_RS12725 ENOG4107T9C Alpha amylase catalytic region HH212_RS12730 ENOG4106HB6 Alpha beta hydrolase HH212_RS12750 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HH212_RS12770 ENOG4105DUX Transporter HH212_RS12775 ENOG4105CG3 alpha amylase, catalytic region HH212_RS12780 ENOG4105CHC glucokinase (EC 2.7.1.2) HH212_RS12790 ENOG4105DQ4 alcohol dehydrogenase HH212_RS12800 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HH212_RS12805 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HH212_RS12830 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HH212_RS12835 ENOG4106NZI LysR family Transcriptional regulator HH212_RS12845 ENOG4105W2Z cytochrome C, class I HH212_RS12850 ENOG4105CP9 extracellular ligand-binding receptor HH212_RS12870 ENOG4105DGW oligopeptidase A HH212_RS12875 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HH212_RS12880 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HH212_RS12885 ENOG4107QSN dihydrolipoamide acetyltransferase HH212_RS12890 ENOG4107QN2 dihydrolipoyl dehydrogenase HH212_RS12900 ENOG4105BZS acriflavin resistance protein HH212_RS12905 ENOG4106KE4 Dehydrogenase HH212_RS12920 ENOG4108VAC response regulator HH212_RS12925 ENOG4108HRK Histidine kinase HH212_RS12960 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH212_RS12970 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS12980 ENOG4105K3G Periplasmic Protein HH212_RS12990 ENOG4105F27 Major Facilitator HH212_RS12995 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HH212_RS13020 ENOG4107QHF type ii secretion system protein e HH212_RS13025 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HH212_RS13040 ENOG4108V3E phosphoribosylglycinamide formyltransferase HH212_RS13050 ENOG4105EGS Mechanosensitive ion channel HH212_RS13070 ENOG4105W0E 50S ribosomal protein L33 HH212_RS13075 ENOG4105KDC 50s ribosomal protein l28 HH212_RS13080 ENOG4108VDT Glycosyl transferase family protein HH212_RS13085 ENOG4105W5Q DNA repair protein (RadC HH212_RS13090 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HH212_RS13100 ENOG4105C32 Amino acid ABC transporter (Permease) HH212_RS13105 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HH212_RS13110 ENOG4105C0Z ABC transporter HH212_RS13115 ENOG4108IV0 ABC, transporter HH212_RS13120 ENOG4108WFY phasin family HH212_RS13135 ENOG41061WM D-Alanyl-D-Alanine HH212_RS13145 ENOG41080IJ Diacylglycerol kinase HH212_RS13150 ENOG4105D3R alkyl hydroperoxide reductase HH212_RS13155 ENOG4107TSN permease HH212_RS13160 ENOG4108I5D sulfate abc transporter HH212_RS13165 ENOG4105ECW sulfate abc transporter HH212_RS13170 ENOG4108IJ6 ABC transporter HH212_RS13175 ENOG4107R11 Transcriptional regulator HH212_RS13180 ENOG4105CPC Aldo Keto reductase HH212_RS13185 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HH212_RS13190 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate HH212_RS13195 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HH212_RS13225 ENOG4105D03 DNA-3-methyladenine glycosylase II HH212_RS13235 ENOG4105ERG peptidase m48, ste24p HH212_RS13240 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HH212_RS13245 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HH212_RS13250 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HH212_RS13255 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HH212_RS13260 ENOG4105DTN riboflavin biosynthesis protein ribF HH212_RS13290 ENOG4105ED1 spovr family HH212_RS13295 ENOG4106AKX UPF0229 protein HH212_RS13300 ENOG4105CYN Serine protein kinase HH212_RS13305 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HH212_RS13310 ENOG4105CV6 ABC transporter, permease HH212_RS13315 ENOG4108Z18 K06886 hemoglobin HH212_RS13325 ENOG4105CVM Molybdenum cofactor synthesis domain protein HH212_RS13330 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HH212_RS13335 ENOG4108Z40 Transcriptional regulator HH212_RS13340 ENOG4105CAY ferredoxin--nadp reductase HH212_RS13345 ENOG4105C03 ribonuclease HH212_RS13350 ENOG4105EI2 Pseudouridine synthase HH212_RS13355 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HH212_RS13375 ENOG4105I08 Pseudouridine synthase HH212_RS13380 ENOG4105HDD phospholipase HH212_RS13400 ENOG4108UT6 Transferase hexapeptide repeat containing protein HH212_RS13405 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HH212_RS13430 ENOG4105D3Q Sugar transferase HH212_RS13445 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HH212_RS13455 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HH212_RS13470 ENOG4105D00 flagellar biosynthetic protein flhB HH212_RS13475 ENOG4105D7B Flagellar biosynthesis protein flha HH212_RS13480 ENOG4105FZW flagellar biosynthesis regulator FlhF HH212_RS13490 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH212_RS13495 ENOG4105E14 MotA TolQ exbB proton channel HH212_RS13500 ENOG4105ER2 Ompa motb domain protein HH212_RS13520 ENOG4105BZU Histidine kinase HH212_RS13525 ENOG4105BZU Histidine kinase HH212_RS13545 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HH212_RS13550 ENOG4108ZC9 flagellar basal-body rod protein flgc HH212_RS13555 ENOG4105W00 Flagellar hook capping protein HH212_RS13560 ENOG4105BZE flagellar hook protein, FlgE HH212_RS13565 ENOG4108KPB Flagellar basal-body rod protein FlgF HH212_RS13570 ENOG4105CGA flagellar basal-body rod protein FlgG HH212_RS13575 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HH212_RS13580 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HH212_RS13585 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HH212_RS13590 ENOG4105E1Q flagellar hook-associated protein HH212_RS13600 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HH212_RS13605 ENOG4105VS8 Flagellar biosynthetic protein fliq HH212_RS13610 ENOG4105CN7 Flagellar biosynthetic protein FliP HH212_RS13615 ENOG4105VTB flagellar biosynthesis protein fliO HH212_RS13620 ENOG4105DD5 Flagellar motor switch protein HH212_RS13625 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HH212_RS13630 ENOG4107ZI8 flagellar basal body-associated protein flil HH212_RS13645 ENOG4108JIR Flagellum-specific ATP synthase HH212_RS13655 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HH212_RS13660 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HH212_RS13665 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HH212_RS13675 ENOG4108N8X transition metal ion binding HH212_RS13685 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HH212_RS13695 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HH212_RS13700 ENOG4105VM1 flagellar HH212_RS13715 ENOG4105MQ3 flagellar protein FliS HH212_RS13720 ENOG4105DTS flagellar hook-associated HH212_RS13720 ENOG4105DTS flagellar hook-associated HH212_RS13720 ENOG4105DTS flagellar hook-associated HH212_RS13730 ENOG4105I03 Flagellin HH212_RS13745 ENOG4105WH1 Two component transcriptional regulator luxr family HH212_RS13750 ENOG4105BZU Histidine kinase HH212_RS13760 ENOG4108RRZ Transcription elongation factor GreB HH212_RS13770 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HH212_RS13775 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HH212_RS13785 ENOG4105DSJ YicC domain protein HH212_RS13790 ENOG4105D9P serine threonine protein kinase HH212_RS13795 ENOG4108ZF3 Phosphatase HH212_RS13810 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HH212_RS13850 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HH212_RS13855 ENOG4105CSA Coproporphyrinogen iii oxidase HH212_RS13860 ENOG4108HRK Histidine kinase HH212_RS13865 ENOG4108NEV two component transcriptional regulator, LytTR family HH212_RS13885 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH212_RS13890 ENOG4105BZS acriflavin resistance protein HH212_RS13895 ENOG4105C1P efflux transporter, rnd family, mfp subunit HH212_RS13905 ENOG4105EA8 2-Nitropropane dioxygenase HH212_RS13915 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS13930 ENOG4105CIR epoxide hydrolase HH212_RS13960 ENOG4105JQN Transcriptional regulator HH212_RS13965 ENOG4107XZQ multidrug resistance protein HH212_RS13985 ENOG4106KNT transcriptional regulator HH212_RS13990 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HH212_RS13995 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HH212_RS14040 ENOG4108JJA ABC, transporter HH212_RS14075 ENOG4107QP8 phosphohexose isomerase HH212_RS14080 ENOG4105C01 Dihydroxy-acid dehydratase HH212_RS14085 ENOG4108UHU Aldolase HH212_RS14110 ENOG4105E66 phosphoriboisomerase A HH212_RS14125 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HH212_RS14130 ENOG4108EKC n-acetylglutamate synthase HH212_RS14135 ENOG4105CQ7 ATP-dependent helicase HH212_RS14150 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HH212_RS14155 ENOG4105CYM Glutathione S-transferase HH212_RS14175 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HH212_RS14180 ENOG4105CFG Acts as a chaperone (By similarity) HH212_RS14250 ENOG4105EJC lysr family transcriptional regulator HH212_RS14255 ENOG4105CGD Nad-dependent epimerase dehydratase HH212_RS14275 ENOG4108ZNX Heat shock protein HH212_RS14280 ENOG4105C0H protease HH212_RS14285 ENOG4105XJC Two component transcriptional regulator (Winged helix family HH212_RS14290 ENOG4105DHQ Histidine kinase HH212_RS14315 ENOG4107RNH Outer membrane receptor FepA HH212_RS14365 ENOG4105C0B DNA polymerase III (alpha subunit) HH212_RS14370 ENOG4105CH2 amidohydrolase HH212_RS14390 ENOG4108M3P Membrane HH212_RS14395 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HH212_RS14400 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HH212_RS14405 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HH212_RS14410 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HH212_RS14435 ENOG4107FW0 short-chain dehydrogenase reductase HH212_RS14445 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HH212_RS14450 ENOG4108Z0R Transferase HH212_RS14455 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HH212_RS14460 ENOG4105DB7 PHP domain protein HH212_RS14465 ENOG4107RTD sua5 ycio yrdc ywlc family protein HH212_RS14470 ENOG4108Z4T Peptidase M50 HH212_RS14480 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HH212_RS14485 ENOG4105GJM (LipO)protein HH212_RS14500 ENOG4105EZE Cupin 4 family protein HH212_RS14505 ENOG4108YZY peptidylprolyl cis-trans isomerase HH212_RS14515 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HH212_RS14530 ENOG4105EXC Acyl-transferase HH212_RS14550 ENOG4105BZ1 (ABC) transporter HH212_RS14595 ENOG4108JQ9 ABC transporter HH212_RS14600 ENOG4105UIB (ABC) transporter HH212_RS14615 ENOG4105C5H ABC transporter HH212_RS14620 ENOG4105C5H ABC transporter HH212_RS14640 ENOG4105BZU Histidine kinase HH212_RS14645 ENOG4105BZU Histidine kinase HH212_RS14650 ENOG4107Z5C methylesterase HH212_RS14655 ENOG4105BZU Histidine kinase HH212_RS14660 ENOG4105D3R alkyl hydroperoxide reductase HH212_RS14665 ENOG4108JU3 Alkyl hydroperoxide reductase HH212_RS14670 ENOG4105C9U ATP-dependent DNA helicase RecQ HH212_RS14675 ENOG4107T0X DNA ligase HH212_RS14680 ENOG4107T0X DNA ligase HH212_RS14685 ENOG4107QRT dEAD DEAH box helicase HH212_RS14700 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HH212_RS14705 ENOG4105WH1 Two component transcriptional regulator luxr family HH212_RS14715 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HH212_RS14725 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HH212_RS14735 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HH212_RS14745 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HH212_RS14760 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HH212_RS14765 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HH212_RS14770 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HH212_RS14775 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HH212_RS14785 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HH212_RS14790 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HH212_RS14800 ENOG4105E96 Colicin v production protein HH212_RS14805 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HH212_RS14810 ENOG4105C28 cystathionine HH212_RS14820 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HH212_RS14825 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HH212_RS14830 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HH212_RS14835 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HH212_RS14840 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HH212_RS14845 ENOG4105CDU Replicative dna helicase HH212_RS14855 ENOG4107QXV Phosphate transporter HH212_RS14875 ENOG410642W LysR family Transcriptional regulator HH212_RS14880 ENOG4107S5I aldo keto reductase HH212_RS14885 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HH212_RS14890 ENOG4105DHT Metal Dependent Phosphohydrolase HH212_RS14895 ENOG4105F8J Adenylate Guanylate cyclase HH212_RS14905 ENOG4105E2R ROK family HH212_RS14930 ENOG4108IAB Phoh family HH212_RS14935 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HH212_RS14945 ENOG4108JU4 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HH212_RS14950 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HH212_RS14955 ENOG4105CKK Glycosyl transferase, family 2 HH212_RS14960 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HH212_RS14965 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HH212_RS14970 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HH212_RS14980 ENOG4105CHM Aminotransferase HH212_RS14985 ENOG4105D6E homoserine dehydrogenase HH212_RS14995 ENOG4105DHQ Histidine kinase HH212_RS15005 ENOG4108Z9W Outer membrane porin HH212_RS15025 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HH212_RS15035 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) HH212_RS15060 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HH212_RS15065 ENOG4105BZU Histidine kinase HH212_RS15070 ENOG4108V3W Chemotaxis protein, CheW HH212_RS15080 ENOG4105CBS Chea signal transduction histidine kinase HH212_RS15090 ENOG4108VYJ response regulator receiver protein HH212_RS15135 ENOG4105DKP glycosyl transferase, family 9 HH212_RS15140 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HH212_RS15145 ENOG4108R85 Short chain dehydrogenase HH212_RS15150 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HH212_RS15200 ENOG4107E2E PKHD-type hydroxylase HH212_RS15205 ENOG4107QM5 aconitate hydratase HH212_RS15225 ENOG4105FDP GntR family transcriptional regulator HH212_RS15230 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HH212_RS15235 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HH212_RS15240 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HH212_RS15245 ENOG4105E33 succinate dehydrogenase HH212_RS15250 ENOG41060IS Flavinator of succinate dehydrogenase HH212_RS15255 ENOG4105BZN citrate synthase HH212_RS15275 ENOG4105BZU Histidine kinase HH212_RS15290 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HH212_RS15310 ENOG4105E3W Two component transcriptional regulator (Winged helix family HH212_RS15315 ENOG4105EB3 Histidine kinase HH212_RS15325 ENOG4107SDU Methyl-accepting chemotaxis HH212_RS15330 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HH212_RS15355 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HH212_RS15360 ENOG4105C7S Dehydrogenase HH212_RS15370 ENOG4107QN2 dihydrolipoyl dehydrogenase HH212_RS15375 ENOG4105D6Z AFG1 family ATPase HH212_RS15385 ENOG4108ZF3 Phosphatase HH212_RS15395 ENOG4105DVT helicase HH212_RS15410 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HH212_RS15415 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HH212_RS15420 ENOG4108K5P (LipO)protein HH212_RS15425 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH212_RS15435 ENOG4105BZU Histidine kinase HH212_RS15440 ENOG4107ENK receptor HH212_RS15450 ENOG4108MN8 Membrane HH212_RS15455 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HH212_RS15460 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HH212_RS15475 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HH212_RS15480 ENOG4105CUT histidyl-tRNA synthetase HH212_RS15495 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HH212_RS15500 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HH212_RS15505 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HH212_RS15510 ENOG4107QJR hflk protein HH212_RS15515 ENOG4105EPW hflc protein HH212_RS15520 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HH212_RS15525 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HH212_RS15530 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HH212_RS15535 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS15540 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HH212_RS15575 ENOG4105CGF Aromatic amino acid aminotransferase HH212_RS15590 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HH212_RS15610 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH212_RS15620 ENOG4105CQZ Histidine kinase HH212_RS15630 ENOG4105BZU Histidine kinase HH212_RS15640 ENOG4105J1V Triacylglycerol lipase HH212_RS15665 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH212_RS15690 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HH212_RS15705 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HH212_RS15710 ENOG4105JXB ankyrin repeat-containing protein HH212_RS15725 ENOG4108RXX maleylacetoacetate isomerase HH212_RS15740 ENOG4105C3J Cysteine desulfurase HH212_RS15745 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HH212_RS15750 ENOG4108Z4V iron-sulfur cluster assembly HH212_RS15755 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HH212_RS15760 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HH212_RS15765 ENOG4108ZIT Ferredoxin, 2FE-2S HH212_RS15770 ENOG4105WVQ Fe-S assembly protein IscX HH212_RS15780 ENOG4105C5W Aldolase HH212_RS15815 ENOG4105C7K acetolactate synthase HH212_RS15820 ENOG4108ZP8 Acetolactate synthase small subunit HH212_RS15825 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HH212_RS15835 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HH212_RS15855 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HH212_RS15860 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HH212_RS15865 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HH212_RS15875 ENOG4107MMM Anti-sigma-factor antagonist HH212_RS15880 ENOG4105FUA antagonist HH212_RS15885 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HH212_RS15895 ENOG4105BZU Histidine kinase HH212_RS15900 ENOG4105BZU Histidine kinase HH212_RS15935 ENOG4105DSG hydrolase family 43 HH212_RS15950 ENOG4105CP7 Triose-phosphate isomerase HH212_RS15955 ENOG4107EJC Preprotein translocase subunit SecG HH212_RS15975 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HH212_RS15980 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HH212_RS15990 ENOG4107QIZ NADH dehydrogenase HH212_RS15995 ENOG4108IEH NADH dehydrogenase subunit g HH212_RS16000 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HH212_RS16005 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HH212_RS16010 ENOG4105DF2 NADH dehydrogenase subunit j HH212_RS16015 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HH212_RS16025 ENOG4105C8S subunit m HH212_RS16030 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HH212_RS16040 ENOG4108YZ4 nudix hydrolase HH212_RS16050 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HH212_RS16055 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HH212_RS16080 ENOG4108YYH Nadph-dependent fmn reductase HH212_RS16085 ENOG4105EYW Ion transport protein HH212_RS16090 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HH212_RS16095 ENOG4105KME endoribonuclease L-psp HH212_RS16100 ENOG41067HZ cytochrome C, class I HH212_RS16120 ENOG4108NEV two component transcriptional regulator, LytTR family HH212_RS16125 ENOG4108HRK Histidine kinase HH212_RS16130 ENOG4105BZU Histidine kinase HH212_RS16135 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HH212_RS16145 ENOG4105BZU Histidine kinase HH212_RS16150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HH212_RS16160 ENOG4105BZU Histidine kinase HH212_RS16185 ENOG4105EB3 Histidine kinase HH212_RS16195 ENOG4108IA2 Sodium pantothenate symporter HH212_RS16200 ENOG4105D07 Signal peptide peptidase, SppA HH212_RS16215 ENOG4105BZS acriflavin resistance protein HH212_RS16220 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH212_RS16225 ENOG4105KPY Small multidrug resistance protein HH212_RS16230 ENOG4105DHU Bile acid HH212_RS16235 ENOG4105CZH peptidase HH212_RS16240 ENOG4105BZU Histidine kinase HH212_RS16245 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH212_RS16250 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HH212_RS16255 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HH212_RS16260 ENOG4105C19 ABC transporter HH212_RS16265 ENOG4105ENT Efflux transporter rnd family, mfp subunit HH212_RS16275 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HH212_RS16320 ENOG4105BZU Histidine kinase HH212_RS16330 ENOG4105E0F Histidine kinase HH212_RS16355 ENOG4108V3W Chemotaxis protein, CheW HH212_RS16360 ENOG4105C5H ABC transporter HH212_RS16365 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HH212_RS16370 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HH212_RS16375 ENOG4105KUZ arsenate reductase HH212_RS16415 ENOG4105CZX twitching motility protein HH212_RS16420 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HH212_RS16425 ENOG4105CHM Aminotransferase HH212_RS16440 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HH212_RS16450 ENOG4105T38 integral membrane protein HH212_RS16455 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HH212_RS16460 ENOG4105CHP RNA polymerase HH212_RS16465 ENOG4105GRZ Ycii-related protein HH212_RS16470 ENOG4105GRZ Ycii-related protein HH212_RS16480 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HH212_RS16495 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HH212_RS16505 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HH212_RS16510 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HH212_RS16515 ENOG4107QNM Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HH212_RS16520 ENOG4107RD7 Flagellar Motor Protein, MotA HH212_RS16525 ENOG4105ER2 Ompa motb domain protein HH212_RS16535 ENOG4108VYJ response regulator receiver protein HH212_RS16540 ENOG4105CBS Chea signal transduction histidine kinase HH212_RS16545 ENOG4108V3W Chemotaxis protein, CheW HH212_RS16550 ENOG4105BZU Histidine kinase HH212_RS16555 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) HH212_RS16560 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HH212_RS16565 ENOG4108VYJ response regulator receiver protein HH212_RS16570 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HH212_RS16575 ENOG4105D58 Diguanylate phosphodiesterase HH212_RS16585 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HH212_RS16605 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HH212_RS16615 ENOG4105EVD ribosomal RNA large subunit methyltransferase N HH212_RS16630 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HH212_RS16695 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HH212_RS16705 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HH212_RS16710 ENOG41066VF YeeE YedE family protein HH212_RS16730 ENOG4105C1J atp-dependent rna helicase HH212_RS16745 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HH212_RS16755 ENOG4105EYH Exonuclease HH212_RS16760 ENOG4107RH8 nuclease SbcCD subunit D HH212_RS16765 ENOG4105T0Z Conserved Protein HH212_RS16785 ENOG4108ZAF Molybdopterin HH212_RS16790 ENOG4108Z12 YiaAB two helix domain-containing protein HH212_RS16795 ENOG4107R4J Chloride channel HH212_RS16800 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH212_RS16810 ENOG4105D6S protein involved in catabolism of external DNA HH212_RS16815 ENOG4105BZU Histidine kinase HH212_RS16825 ENOG4108UHJ MAF-like protein HH212_RS16835 ENOG4105VGS 50s ribosomal protein l32 HH212_RS16840 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HH212_RS16845 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HH212_RS16850 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HH212_RS16855 ENOG4105CHR reductase HH212_RS16860 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HH212_RS16865 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HH212_RS16875 ENOG4105EMN RNA polymerase sigma factor HH212_RS16885 ENOG4105C0H protease HH212_RS16895 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HH212_RS16900 ENOG4105C3F Signal peptidase i HH212_RS16915 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HH212_RS16920 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HH212_RS16925 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HH212_RS16930 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HH212_RS16935 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HH212_RS16975 ENOG4105CF7 AraC family transcriptional regulator HH212_RS17000 ENOG4105CAF HipA N-terminal domain protein HH212_RS17040 ENOG4105IBP Cyclic peptide transporter HH212_RS17095 ENOG4105VJY transcriptional regulator HH212_RS17100 ENOG4108TSE Transferase HH212_RS17115 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HH212_RS17135 ENOG4105DJY efflux transporter, rnd family, mfp subunit HH212_RS17140 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH212_RS17145 ENOG4105C54 Major Facilitator superfamily HH212_RS17150 ENOG4105ETE Transcriptional regulator (LacI family HH212_RS17160 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HH212_RS17185 ENOG4105CG3 alpha amylase, catalytic region HH212_RS17190 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HH212_RS17195 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HH212_RS17205 ENOG4108IUM Glycogen debranching enzyme HH212_RS17275 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH212_RS17280 ENOG4105CS6 Rhs element vgr protein HH212_RS17305 ENOG4105CK2 sodium dicarboxylate symporter HH212_RS17335 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HH212_RS17370 ENOG4105C3J Cysteine desulfurase HH212_RS17375 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HH212_RS17380 ENOG4105DZ2 Transcriptional regulator HH212_RS17385 ENOG4105DDY UPF0142 protein ycaO HH212_RS17400 ENOG4107SQD Transcriptional regulator, GntR family HH212_RS17435 ENOG4108JQ5 ABC transporter HH212_RS17440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HH212_RS17445 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HH212_RS17450 ENOG4106R87 Extracellular solute-binding protein, family 5 HH212_RS17455 ENOG41080C8 DUF218 domain HH212_RS17460 ENOG4107RFB Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HH212_RS17485 ENOG4105DMF Dehydrogenase HH212_RS17495 ENOG4108ZXC Two component transcriptional regulator, luxr family HH212_RS17500 ENOG4105BZU Histidine kinase HH212_RS17505 ENOG4105CSH Transporter HH212_RS17530 ENOG4105D05 Receptor HH212_RS17545 ENOG4105CIG ABC transporter HH212_RS17555 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HH212_RS17560 ENOG4105BZU Histidine kinase HH212_RS17580 ENOG4105D9U N-acetyltransferase HH212_RS17605 ENOG4105CEY Amp-dependent synthetase and ligase HH212_RS17610 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HH212_RS17615 ENOG4105D4P Coproporphyrinogen iii oxidase HH212_RS17645 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HH212_RS17655 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HH212_RS17670 ENOG4105C4M (Ubiquinol oxidase) subunit I HH212_RS17675 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HH212_RS17690 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HH212_RS17705 ENOG4107RH7 Nicotinate phosphoribosyltransferase HH212_RS17710 ENOG4108KPJ rna polymerase sigma factor HH212_RS17715 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HH212_RS17725 ENOG4105BZU Histidine kinase HH212_RS17770 ENOG4105FN4 Depolymerizes alginate by cleaving the beta-1,4 glycosidic bond (By similarity) HH212_RS17785 ENOG4105HSS phospholipase C HH212_RS17800 ENOG4105EEQ Na H antiporter HH212_RS17810 ENOG4105C08 Histidine kinase HH212_RS17825 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HH212_RS17870 ENOG4105C4R Atp-dependent dna helicase HH212_RS17875 ENOG4108R7K Metal Dependent Phosphohydrolase HH212_RS17880 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HH212_RS17910 ENOG4105VJY transcriptional regulator HH212_RS17925 ENOG4105DSY exodeoxyribonuclease V, gamma HH212_RS17930 ENOG4107QKA exodeoxyribonuclease V beta HH212_RS17935 ENOG4107QYX exodeoxyribonuclease v alpha HH212_RS17940 ENOG4105BZU Histidine kinase HH212_RS17955 ENOG41061WM D-Alanyl-D-Alanine HH212_RS17960 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HH212_RS17965 ENOG41082BV acetyltransferase HH212_RS17975 ENOG4105WG9 Conserved Protein HH212_RS17995 ENOG4105BZU Histidine kinase HH212_RS18000 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HH212_RS18005 ENOG4108R85 Short chain dehydrogenase HH212_RS18035 ENOG4105D0M Protease HtpX homolog HH212_RS18060 ENOG4105CK2 sodium dicarboxylate symporter HH212_RS18085 ENOG4105DTD Dehydrogenase HH212_RS18095 ENOG4105M4H endoribonuclease L-psp HH212_RS18100 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HH212_RS18120 ENOG4108302 MgtC SapB transporter HH212_RS18125 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HH212_RS18130 ENOG4105C3M thioredoxin reductase HH212_RS18135 ENOG4105PGM cation diffusion facilitator family transporter HH212_RS18145 ENOG4105C22 threonyL-tRNA synthetase HH212_RS18150 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HH212_RS18155 ENOG4105VJV 50s ribosomal protein L35 HH212_RS18160 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HH212_RS18165 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HH212_RS18175 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HH212_RS18215 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HH212_RS18220 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HH212_RS18250 ENOG4105CH6 catalase HH212_RS18260 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HH212_RS18265 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HH212_RS18270 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HH212_RS18290 ENOG4105DHJ ABC, transporter HH212_RS18335 ENOG4105EHU Circadian clock protein KaiC HH212_RS18340 ENOG4105BZU Histidine kinase HH212_RS18360 ENOG4105BZU Histidine kinase HH212_RS18375 ENOG4105DUX Transporter HH212_RS18385 ENOG4105FE9 pseudouridine synthase HH212_RS18390 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HH212_RS18395 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HH212_RS18400 ENOG4105CE9 30S ribosomal protein S2 HH212_RS18405 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HH212_RS18410 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HH212_RS18415 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HH212_RS18420 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HH212_RS18425 ENOG4105KNE Phosphatidate cytidylyltransferase HH212_RS18430 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HH212_RS18435 ENOG4105DZP Membrane-associated zinc metalloprotease HH212_RS18440 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HH212_RS18450 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HH212_RS18455 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HH212_RS18460 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HH212_RS18465 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HH212_RS18470 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HH212_RS18480 ENOG4105BZU Histidine kinase HH212_RS18485 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HH212_RS18490 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HH212_RS18500 ENOG4105BZU Histidine kinase HH212_RS18540 ENOG4105C3F Signal peptidase i HH212_RS18545 ENOG4105D94 Major Facilitator Superfamily HH212_RS18550 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HH212_RS18555 ENOG4108Z1B Cyclase dehydrase HH212_RS18560 ENOG4105VDB UPF0125 protein HH212_RS18570 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HH212_RS18575 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HH212_RS18595 ENOG4105F9F transposase HH212_RS18650 ENOG4105VXP Protein of unknown function DUF86 HH212_RS18695 ENOG4105DJB Major Facilitator Superfamily HH212_RS18700 ENOG4107RSM transcriptional regulator HH212_RS18705 ENOG4105WH1 Two component transcriptional regulator luxr family HH212_RS18710 ENOG4105BZU Histidine kinase HH212_RS18765 ENOG4105EDV vault protein HH212_RS18770 ENOG41081SK signal peptide protein HH212_RS18775 ENOG4107S52 alpha-2-macroglobulin domain protein HH212_RS18780 ENOG4108QJJ Protein of unknown function (DUF1175) HH212_RS18785 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HH212_RS18790 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HH212_RS18805 ENOG4108RCM Nitroreductase HH212_RS18810 ENOG4107RM6 sulfurtransferase HH212_RS18830 ENOG4105CNT hydrolase family 2 HH212_RS18840 ENOG4105EWU Squalene--hopene cyclase HH212_RS18890 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HH212_RS18935 ENOG4107WN4 Polygalacturonase HH212_RS18940 ENOG4107TDE lipolytic protein G-D-S-L family HH212_RS18945 ENOG4105D05 Receptor HH212_RS18950 ENOG4105F5H Glycosyl Hydrolase Family 88 HH212_RS18970 ENOG4105C6F GntR Family Transcriptional Regulator HH212_RS18975 ENOG4105CPC Aldo Keto reductase HH212_RS18980 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HH212_RS18985 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HH212_RS18990 ENOG4108HKT sucrose-6-phosphate hydrolase HH212_RS19035 ENOG4107SFQ iron-sulfur binding HH212_RS19070 ENOG4105Z4T Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HH212_RS19080 ENOG4107QS1 Cytochrome C Oxidase, Subunit III HH212_RS19150 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HH212_RS19155 ENOG4105HEI LysR family (Transcriptional regulator HH212_RS19160 ENOG4108RYK Nad-dependent epimerase dehydratase HH212_RS19165 ENOG4108MP6 LysR family Transcriptional regulator HH212_RS19170 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HH212_RS19245 ENOG4107KJX Transcriptional regulator HH212_RS19280 ENOG4105EW6 flavin reductase domain protein, FMN-binding HH212_RS19300 ENOG4105BZU Histidine kinase HH212_RS19385 ENOG4107SDU Methyl-accepting chemotaxis HH212_RS19390 ENOG4105BZU Histidine kinase HH212_RS19395 ENOG4108720 CheD chemotactic sensory transduction HH212_RS19400 ENOG4108V3W Chemotaxis protein, CheW HH212_RS19405 ENOG4105E9Z Nad-dependent epimerase dehydratase HH212_RS19420 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HH212_RS19425 ENOG4105FDP GntR family transcriptional regulator HH212_RS19430 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HH212_RS19435 ENOG4107SUZ Sodium/hydrogen exchanger family HH212_RS19465 ENOG4108JQ6 ABC transporter HH212_RS19475 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HH212_RS19495 ENOG4107R11 Transcriptional regulator HH212_RS19565 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HH212_RS19600 ENOG4108HMN Caspase domain HH212_RS19620 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HH212_RS19630 ENOG4105C2J ABC transporter HH212_RS19635 ENOG4105D4B ABC, transporter HH212_RS19650 ENOG4105C9F isomerase HH212_RS19665 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HH212_RS19685 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis HH212_RS19695 ENOG4105ERH Fumarylacetoacetate hydrolase HH212_RS19720 ENOG4107TDE lipolytic protein G-D-S-L family HH212_RS19725 ENOG4105EKC HH212_RS19735 ENOG4105F5H Glycosyl Hydrolase Family 88 HH212_RS19750 ENOG4107TDE lipolytic protein G-D-S-L family HH212_RS19755 ENOG4108J21 pectate lyase HH212_RS19765 ENOG4105CX8 fg-gap repeat protein HH212_RS19820 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HH212_RS19855 ENOG4105ED9 Protein of unknown function (DUF455) HH212_RS19860 ENOG4105CQ2 DNA polymerase HH212_RS19865 ENOG4105EDV vault protein HH212_RS19880 ENOG4108R6G acetyltransferase HH212_RS19915 ENOG4105DQ4 alcohol dehydrogenase HH212_RS19920 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HH212_RS19930 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HH212_RS19935 ENOG4105MWK D-amino acid dehydrogenase, small subunit HH212_RS19940 ENOG4105EW9 transcriptional regulator AsnC family HH212_RS19985 ENOG4105NVB glycoside hydrolase, family 19 HH212_RS19990 ENOG4105CS6 Rhs element vgr protein HH212_RS20020 ENOG4108WC9 type VI secretion system effector, hcp1 family HH212_RS20040 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH212_RS20075 ENOG41068JE domain protein HH212_RS20080 ENOG4105CS6 Rhs element vgr protein HH212_RS20125 ENOG4105BZU Histidine kinase HH212_RS20190 ENOG4105E2X shikimate dehydrogenase HH212_RS20205 ENOG4105D05 Receptor HH212_RS20220 ENOG4105DPW Major facilitator superfamily MFS_1 HH212_RS20225 ENOG4105D7K pfkb domain protein HH212_RS20235 ENOG4105CHR reductase HH212_RS20240 ENOG4105ETE Transcriptional regulator (LacI family HH212_RS20250 ENOG4105D05 Receptor HH212_RS20270 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase HH212_RS20300 ENOG4105D0H Alpha-glucuronidase (EC 3.2.1.139) HH212_RS20305 ENOG4105ETE Transcriptional regulator (LacI family HH212_RS20360 ENOG4105E9Z Nad-dependent epimerase dehydratase HH212_RS20400 ENOG4105D3P Mannan endo-1,4-beta-mannosidase HH212_RS20425 ENOG41090KN UPF0303 protein HH212_RS20430 ENOG4105BZU Histidine kinase HH212_RS20435 ENOG4105QV4 Tryptophan halogenase HH212_RS20450 ENOG4105E08 Glycoside hydrolase, family 9 HH212_RS20480 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HH212_RS20485 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS20495 ENOG4105BZU Histidine kinase HH212_RS20505 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HH212_RS20510 ENOG4108XHQ (2Fe-2S)-binding domain protein HH212_RS20515 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HH212_RS20520 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS20570 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HH212_RS20575 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HH212_RS20580 ENOG4105C7W Xanthine dehydrogenase HH212_RS20585 ENOG4107SCK Monooxygenase HH212_RS20595 ENOG4105I8F Histidine kinase HH212_RS20620 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HH212_RS20625 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HH212_RS20655 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HH212_RS20665 ENOG4108K70 Transcriptional regulator HH212_RS20695 ENOG4105X1P Steroid delta-isomerase HH212_RS20710 ENOG4105Z6B inner membrane protein yjfl HH212_RS20730 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HH212_RS20750 ENOG4105CPC Aldo Keto reductase HH212_RS20760 ENOG4108YXU transcriptional regulator AsnC family HH212_RS20800 ENOG4105CWU Biogenesis protein HH212_RS20845 ENOG4108IG5 Transcriptional regulator HH212_RS20850 ENOG4105CBD Diacylglycerol kinase HH212_RS20855 ENOG4105BZU Histidine kinase HH212_RS20865 ENOG4105DIQ Transcriptional regulator HH212_RS20870 ENOG4105BZU Histidine kinase HH212_RS20875 ENOG4105CS1 NAD(P)H quinone oxidoreductase HH212_RS20890 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component HH212_RS20900 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HH212_RS20940 ENOG4105CHC glucokinase (EC 2.7.1.2) HH212_RS20945 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HH212_RS20955 ENOG4105EXC Acyl-transferase HH212_RS21045 ENOG4105EQ0 Major Facilitator superfamily HH212_RS21050 ENOG4105BZU Histidine kinase HH212_RS21060 ENOG4108VSE mercuric transport protein HH212_RS21065 ENOG4108KS2 transglutaminase domain protein HH212_RS21070 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HH212_RS21075 ENOG4105CNT hydrolase family 2 HH212_RS21080 ENOG4105C08 Histidine kinase HH212_RS21085 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HH212_RS21090 ENOG4105CKD glutathione-regulated potassium-efflux system protein HH212_RS21105 ENOG4107QN2 dihydrolipoyl dehydrogenase HH212_RS21110 ENOG4107QSN dihydrolipoamide acetyltransferase HH212_RS21115 ENOG4105CPP Dehydrogenase, E1 component HH212_RS21120 ENOG4107R0V Pyruvate dehydrogenase HH212_RS21135 ENOG4105CGK Exodeoxyribonuclease III HH212_RS21140 ENOG4105CJQ hydrolase, family 31 HH212_RS21165 ENOG4108V06 Glutathione peroxidase HH212_RS21185 ENOG4105C85 amino acid HH212_RS21205 ENOG4105F1J Homogentisate 1,2-dioxygenase HH212_RS21220 ENOG4105VAW lrga family HH212_RS21225 ENOG41067MG lrgb family HH212_RS21235 ENOG4105CSH Transporter HH212_RS21240 ENOG4105E2S oxidase) subunit II HH212_RS21245 ENOG4105BZ9 Cytochrome C oxidase, subunit I HH212_RS21250 ENOG4105CCU oxidase (Subunit III) HH212_RS21255 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HH212_RS21265 ENOG4105TX3 Histidine kinase HH212_RS21270 ENOG4108UYB regulatoR HH212_RS21280 ENOG4107RNH Outer membrane receptor FepA HH212_RS21310 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HH212_RS21320 ENOG4105CMQ Chloride channel HH212_RS21325 ENOG4105BZU Histidine kinase HH212_RS21330 ENOG4108JQC penicillin-binding protein 1A HH212_RS21340 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HH212_RS21345 ENOG4105D64 Mechanosensitive ion channel HH212_RS21350 ENOG4108MR6 WD40-like Beta Propeller Repeat HH212_RS21355 ENOG4105K63 Thioredoxin HH212_RS21360 ENOG4105CSH Transporter HH212_RS21390 ENOG4105WH1 Two component transcriptional regulator luxr family HH212_RS21400 ENOG4105CV8 reductase HH212_RS21415 ENOG4105C7N Xanthine uracil vitamin C permease HH212_RS21425 ENOG4105D2H Uronic isomerase HH212_RS21430 ENOG4105CTX dehydratase HH212_RS21435 ENOG4107QZW Altronate oxidoreductase HH212_RS21440 ENOG4105DPW Major facilitator superfamily MFS_1 HH212_RS21455 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HH212_RS21465 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS21505 ENOG4105ES5 Histidine kinase HH212_RS21555 ENOG4107XVI synthase HH212_RS21560 ENOG4108Z6B deaminase HH212_RS21570 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HH212_RS21575 ENOG4105C5H ABC transporter HH212_RS21580 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HH212_RS21585 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HH212_RS21590 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HH212_RS21600 ENOG4108IYU L-aspartate oxidase HH212_RS21605 ENOG4105E2K Glycosyl transferase (Group 1 HH212_RS21610 ENOG4105CPK Glycosyl transferase (Group 1 HH212_RS21625 ENOG4105CI2 imidazolone-5-propionate hydrolase HH212_RS21645 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH212_RS21660 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HH212_RS21665 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HH212_RS21670 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HH212_RS21675 ENOG4105C08 Histidine kinase HH212_RS21680 ENOG4105EEX Two component transcriptional regulator (Winged helix family HH212_RS21780 ENOG4105DIA mandelate racemase muconate lactonizing HH212_RS21785 ENOG4105DJB Major Facilitator Superfamily HH212_RS21790 ENOG4108Z9W Outer membrane porin HH212_RS21795 ENOG4105CTX dehydratase HH212_RS21800 ENOG4105K2J Transcriptional regulator HH212_RS21855 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HH212_RS21865 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HH212_RS21870 ENOG4108MG3 formate dehydrogenase HH212_RS21875 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HH212_RS21880 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HH212_RS21885 ENOG4105EM7 Selenocysteine-specific translation elongation factor HH212_RS21905 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HH212_RS21910 ENOG4105CFP Peptidase U32 HH212_RS21920 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH212_RS21965 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HH212_RS21975 ENOG4105F8V Hydrolase, tatD family HH212_RS21980 ENOG4107TCE N-acetyltransferase HH212_RS21990 ENOG4107QRG dna polymerase iii HH212_RS21995 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HH212_RS22000 ENOG4105HHA aminodeoxychorismate lyase HH212_RS22005 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HH212_RS22020 ENOG4105BZU Histidine kinase HH212_RS22035 ENOG4105DTD Dehydrogenase HH212_RS22065 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HH212_RS22075 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HH212_RS22090 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HH212_RS22100 ENOG4105CNG UPF0061 protein HH212_RS22105 ENOG4105E0X reductase HH212_RS22110 ENOG4107835 probably involved in intracellular septation (By similarity) HH212_RS22120 ENOG4107TF3 peptidylprolyl cis-trans isomerase HH212_RS22125 ENOG4107TF3 peptidylprolyl cis-trans isomerase HH212_RS22140 ENOG4108ETH Formylglycinamide ribotide synthetase HH212_RS22145 ENOG4108VYJ response regulator receiver protein HH212_RS22155 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HH212_RS22170 ENOG4108I0Y (ABC) transporter HH212_RS22175 ENOG4108UJV acyl-CoA thioesterase i HH212_RS22180 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) HH212_RS22185 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HH212_RS22200 ENOG4105K70 DNA-binding protein HH212_RS22205 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HH212_RS22210 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HH212_RS22215 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HH212_RS22220 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HH212_RS22230 ENOG4105BZS acriflavin resistance protein HH212_RS22295 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HH212_RS22300 ENOG4108YXU transcriptional regulator AsnC family HH212_RS22305 ENOG41085JF Trap dicarboxylate transporter-dctp subunit HH212_RS22310 ENOG4105M00 molybdopterin converting factor, subunit 1 HH212_RS22315 ENOG4105CVM Molybdenum cofactor synthesis domain protein HH212_RS22325 ENOG4105EJQ L-serine dehydratase HH212_RS22330 ENOG4105EXW epimerase dehydratase HH212_RS22335 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HH212_RS22370 ENOG4105R8A Heat shock protein HH212_RS22380 ENOG4105D44 asparaginase HH212_RS22400 ENOG4108DIG cyanophycin synthetase HH212_RS22410 ENOG4105CUB amino acid HH212_RS22415 ENOG4105DIN metallophosphoesterase HH212_RS22420 ENOG4105N14 lysine exporter protein LysE YggA HH212_RS22430 ENOG4107T8P acyl-Coa dehydrogenase HH212_RS22435 ENOG4105D01 (LipO)protein HH212_RS22445 ENOG4105DSF transport protein HH212_RS22460 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HH212_RS22465 ENOG4105EQ2 LysR family Transcriptional regulator HH212_RS22470 ENOG4105C7W Xanthine dehydrogenase HH212_RS22475 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HH212_RS22480 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HH212_RS22505 ENOG4105DJB Major Facilitator Superfamily HH212_RS22510 ENOG4105C5R Aminotransferase HH212_RS22515 ENOG4107XBN GntR Family Transcriptional Regulator HH212_RS22520 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HH212_RS22530 ENOG4105EMN RNA polymerase sigma factor HH212_RS22540 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HH212_RS22555 ENOG4105DIJ Phosphoethanolamine transferase HH212_RS22575 ENOG4105F9F transposase HH212_RS22600 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HH212_RS22615 ENOG4105EEQ Na H antiporter HH212_RS22650 ENOG4105D64 Mechanosensitive ion channel HH212_RS22700 ENOG4105BZU Histidine kinase HH212_RS22730 ENOG4105BZU Histidine kinase HH212_RS22745 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HH212_RS22750 ENOG4105E6M Sulphatase-modifying factor protein HH212_RS22755 ENOG4105C09 Bile acid HH212_RS22765 ENOG4105EKQ RNA-directed DNA polymerase HH212_RS22805 ENOG4105C0D helicase HH212_RS22830 ENOG4105BZU Histidine kinase HH212_RS23010 ENOG4107RZZ dna polymerase iii epsilon subunit HH212_RS23015 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HH212_RS23020 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HH212_RS23025 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HH212_RS23030 ENOG4107QP3 malate synthase g HH212_RS23035 ENOG4105EJC lysr family transcriptional regulator HH212_RS23040 ENOG4105VEQ Cold shock protein HH212_RS23050 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HH212_RS23055 ENOG4105CSU acyl-Coa dehydrogenase HH212_RS23060 ENOG4105BZU Histidine kinase HH212_RS23070 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HH212_RS23075 ENOG4105BZU Histidine kinase HH212_RS23085 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HH212_RS23095 ENOG4107S2Z UPF0761 membrane protein HH212_RS23100 ENOG4105CS1 NAD(P)H quinone oxidoreductase HH212_RS23110 ENOG4105CQB FAD linked oxidase domain protein HH212_RS23125 ENOG4105BZ1 (ABC) transporter HH212_RS23130 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS23150 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HH212_RS23170 ENOG4105CXN decarboxylase HH212_RS23175 ENOG4105DHP deoxycytidine triphosphate deaminase HH212_RS23190 ENOG4105E3W Two component transcriptional regulator (Winged helix family HH212_RS23195 ENOG4105E0F Histidine kinase HH212_RS23215 ENOG4108EC8 DNA internalization-related competence protein ComEC HH212_RS23230 ENOG4105CS6 Rhs element vgr protein HH212_RS23235 ENOG4105EYA deoxyribonuclease HH212_RS23240 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HH212_RS23245 ENOG4105D60 lipoprotein releasing system transmembrane protein HH212_RS23255 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HH212_RS23295 ENOG4107RAN Peptidase, M16 HH212_RS23305 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HH212_RS23320 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HH212_RS23325 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS23340 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HH212_RS23355 ENOG4105CRK lysyL-tRNA synthetase HH212_RS23360 ENOG4105EWT decarboxylase family HH212_RS23365 ENOG4105DUX Transporter HH212_RS23375 ENOG4105EEQ Na H antiporter HH212_RS23400 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH212_RS23420 ENOG4105CNA YD repeat protein HH212_RS23450 ENOG4105EPD Oligopeptide transporter, Opt family HH212_RS23455 ENOG4108JQC penicillin-binding protein 1A HH212_RS23470 ENOG4108JA2 transcriptioN-repair coupling factor HH212_RS23475 ENOG4105EAC phosphoserine phosphatase HH212_RS23485 ENOG4105BZU Histidine kinase HH212_RS23505 ENOG4105C0Z ABC transporter HH212_RS23510 ENOG4108IV0 ABC, transporter HH212_RS23520 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HH212_RS23530 ENOG4105C9B Cysteine desulfurase HH212_RS23535 ENOG4105BZW Glycerate kinase HH212_RS23540 ENOG4105CSP Major Facilitator Superfamily HH212_RS23545 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HH212_RS23570 ENOG4105K63 Thioredoxin HH212_RS23580 ENOG4105C28 cystathionine HH212_RS23585 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HH212_RS23595 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class HH212_RS23605 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HH212_RS23610 ENOG4105C34 Pseudouridine synthase HH212_RS23630 ENOG4105EJC lysr family transcriptional regulator HH212_RS23635 ENOG4105D1Q UPF0246 protein HH212_RS23645 ENOG4105CHM Aminotransferase HH212_RS23710 ENOG4105KHS type IV fimbrial pilin protein HH212_RS23715 ENOG4105D7Q type ii secretion system HH212_RS23720 ENOG4107QHF type ii secretion system protein e HH212_RS23725 ENOG4105BZU Histidine kinase HH212_RS23740 ENOG4105CN1 protease HH212_RS23750 ENOG4107104 thymidine kinase HH212_RS23760 ENOG4107SQI penicillin amidase HH212_RS23790 ENOG4105BZU Histidine kinase HH212_RS23800 ENOG4105F7F Chaperone HH212_RS23805 ENOG4108RAV Conserved protein HH212_RS23830 ENOG4107QPV Serine Threonine protein kinase HH212_RS23865 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS23870 ENOG4105E6M Sulphatase-modifying factor protein HH212_RS23920 ENOG4105EST Metal Dependent Phosphohydrolase HH212_RS23930 ENOG4105DJ4 phosphatidylserine decarboxylase HH212_RS23940 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HH212_RS23945 ENOG4105EUB pirin domain protein HH212_RS23970 ENOG4105EYK Phosphatidylglycerophosphatase B HH212_RS23975 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HH212_RS23980 ENOG4105CKK Glycosyl transferase, family 2 HH212_RS24015 ENOG4105BZU Histidine kinase HH212_RS24020 ENOG4105BZU Histidine kinase HH212_RS24035 ENOG4105K89 arsenate reductase HH212_RS24045 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HH212_RS24050 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HH212_RS24055 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HH212_RS24060 ENOG4105CQM Urea amidohydrolase subunit alpha HH212_RS24075 ENOG4108YZ9 Urea amidohydrolase subunit gamma HH212_RS24080 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HH212_RS24095 ENOG4105BZU Histidine kinase HH212_RS24100 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HH212_RS24105 ENOG4105FDF Could be involved in DNA repair (By similarity) HH212_RS24115 ENOG4105DQE DNA ligase HH212_RS24130 ENOG4105C5I Dehydrogenase HH212_RS24165 ENOG4105BZU Histidine kinase HH212_RS24185 ENOG4105BZU Histidine kinase HH212_RS24200 ENOG4105BZU Histidine kinase HH212_RS24210 ENOG4105BZU Histidine kinase HH212_RS24215 ENOG4105CEP NADH dehydrogenase HH212_RS24230 ENOG4105C1J atp-dependent rna helicase HH212_RS24240 ENOG4106Z5D Glycoside Hydrolase Family 43 HH212_RS24260 ENOG4105W4C monovalent cation H antiporter subunit F HH212_RS24265 ENOG4105SC1 monovalent cation H antiporter subunit E HH212_RS24270 ENOG4107R4Z monovalent cation h antiporter subunit d HH212_RS24275 ENOG4108ZE9 Monovalent cation H antiporter subunit C HH212_RS24280 ENOG4105D65 subunit l HH212_RS24295 ENOG4105C8Q Methyl-accepting chemotaxis HH212_RS24325 ENOG4105CD5 CoA-binding domain protein HH212_RS24330 ENOG4105PGM cation diffusion facilitator family transporter HH212_RS24365 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HH212_RS24370 ENOG4105BZU Histidine kinase HH212_RS24420 ENOG4105CYM Glutathione S-transferase HH212_RS24425 ENOG410904N short-chain dehydrogenase reductase HH212_RS24430 ENOG4105EUB pirin domain protein HH212_RS24440 ENOG4105F52 Transcriptional regulator HH212_RS24445 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HH212_RS24450 ENOG410902C phosphohistidine phosphatase, SixA HH212_RS24500 ENOG4105C9X ppx gppa phosphatase HH212_RS24525 ENOG4108ZG0 Ompa motb domain protein HH212_RS24530 ENOG4105DDV Transcriptional regulator (LacI family HH212_RS24555 ENOG4105D05 Receptor HH212_RS24590 ENOG4108Z9W Outer membrane porin HH212_RS24600 ENOG4105D2S major facilitator superfamily HH212_RS24605 ENOG4107F9Y LysR family transcriptional regulator HH212_RS24615 ENOG4105KHM amidohydrolase 2 HH212_RS24625 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HH212_RS24635 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HH212_RS24640 ENOG4108HRK Histidine kinase HH212_RS24645 ENOG4108VAC response regulator HH212_RS24655 ENOG4105CK2 sodium dicarboxylate symporter HH212_RS24665 ENOG410811B TRANSCRIPTIONal HH212_RS24670 ENOG4105GAK amidohydrolase 2 HH212_RS24680 ENOG4105DBI uridine monophosphokinase HH212_RS24690 ENOG4105DFH Transport of potassium into the cell (By similarity) HH212_RS24705 ENOG4105EM2 membrane HH212_RS24720 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HH212_RS24760 ENOG4107QKZ Ompa motb domain protein HH212_RS24850 ENOG4105DFP Integrase HH212_RS24860 ENOG4105CFH Aspartokinase HH212_RS24865 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HH212_RS24870 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HH212_RS24880 ENOG4105C8N cysteinyl-tRNA synthetase HH212_RS24885 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HH212_RS24895 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HH212_RS24905 ENOG4105CZV ABC transporter HH212_RS24915 ENOG4108YXG UPF0502 protein HH212_RS24920 ENOG4105D7W serine acetyltransferase HH212_RS24925 ENOG4105C2N RNA methyltransferase TrmH family group 3 HH212_RS24980 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH212_RS24990 ENOG4108WC9 type VI secretion system effector, hcp1 family HH212_RS25050 ENOG4105F2V VRR-NUC domain-containing protein HH212_RS25060 ENOG4108NEV two component transcriptional regulator, LytTR family HH212_RS25065 ENOG4108HRK Histidine kinase HH212_RS25105 ENOG4107QQG Dehydrogenase HH212_RS25115 ENOG4105J5G Transferase hexapeptide repeat containing protein HH212_RS25120 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HH212_RS25145 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HH212_RS25180 ENOG4105E8R UPF0173 metal-dependent hydrolase HH212_RS25195 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HH212_RS25200 ENOG4105EEI dihydropteroate synthase HH212_RS25205 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HH212_RS25210 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HH212_RS25225 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HH212_RS25230 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HH212_RS25235 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HH212_RS25240 ENOG4108ZJF Glcg protein HH212_RS25245 ENOG4105D78 K07001 NTE family protein HH212_RS25250 ENOG4105BZU Histidine kinase HH212_RS25255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HH212_RS25265 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HH212_RS25270 ENOG4105E2Z phosphate ABC transporter (Permease HH212_RS25275 ENOG4105C8U phosphate abc transporter HH212_RS25280 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HH212_RS25290 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HH212_RS25295 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HH212_RS25300 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) HH212_RS25310 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HH212_RS25320 ENOG41072GX Peptidase M22 Glycoprotease HH212_RS25330 ENOG4105BZU Histidine kinase HH212_RS25350 ENOG4105E9H Lytic Murein transglycosylase HH212_RS25355 ENOG4105C1J atp-dependent rna helicase HH212_RS25360 ENOG4105E6M Sulphatase-modifying factor protein HH212_RS25370 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HH212_RS25390 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HH212_RS25400 ENOG4107S2Z UPF0761 membrane protein HH212_RS25405 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HH212_RS25410 ENOG41067HS methyltransferase HH212_RS25430 ENOG4105BZU Histidine kinase HH212_RS25435 ENOG4105I7M spermidine synthase HH212_RS25440 ENOG4105BZU Histidine kinase HH212_RS25480 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HH212_RS25505 ENOG4105CGZ zinc metallopeptidase HH212_RS25535 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HH212_RS25570 ENOG4105D1H recombination factor protein RarA HH212_RS25580 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HH212_RS25595 ENOG4105C3M thioredoxin reductase HH212_RS25600 ENOG4108DG9 Smr protein MutS2 HH212_RS25605 ENOG4105BZU Histidine kinase HH212_RS25610 ENOG4105EN6 Membrane HH212_RS25615 ENOG4108YZA Nitrogen regulatory protein pii HH212_RS25620 ENOG4108DWA Nad synthetase HH212_RS25630 ENOG41080E2 ribosomal-protein-alanine acetyltransferase HH212_RS25640 ENOG4107ZSV Receptor HH212_RS25655 ENOG4105C0Z ABC transporter HH212_RS25660 ENOG4108IV0 ABC, transporter HH212_RS25685 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HH212_RS25690 ENOG4105F0N pyrophosphate phospho-hydrolase HH212_RS25700 ENOG4105ECF c-methyltransferase HH212_RS25705 ENOG41076E6 Uroporphyrinogen-III Synthase HH212_RS25710 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HH212_RS25715 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HH212_RS25740 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH212_RS25765 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HH212_RS25770 ENOG4105CZX twitching motility protein HH212_RS25795 ENOG4108VWS Yaeq family HH212_RS25800 ENOG4105CIY formyltetrahydrofolate deformylase HH212_RS25810 ENOG4108VKG metal-dependent hydrolase HH212_RS25825 ENOG4105BZU Histidine kinase HH212_RS25830 ENOG4105BZU Histidine kinase HH212_RS25835 ENOG4108URH decarboxylase HH212_RS25840 ENOG4108XG4 DNA-binding transcriptional regulator HH212_RS25850 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HH212_RS25855 ENOG4105ECY inositol monophosphatase HH212_RS25860 ENOG4105C1J atp-dependent rna helicase HH212_RS25875 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HH212_RS25890 ENOG4105CHR reductase HH212_RS25905 ENOG4105EHV domain protein HH212_RS25915 ENOG4105UYK outer membrane protein a HH212_RS25920 ENOG4107S2Z UPF0761 membrane protein HH212_RS25925 ENOG4105DSF transport protein HH212_RS25960 ENOG4105CDV Ompa motb domain protein HH212_RS25970 ENOG41066T0 asmA family HH212_RS25980 ENOG41061RM osmotically inducible lipoprotein HH212_RS26005 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HH212_RS26020 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HH212_RS26025 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HH212_RS26035 ENOG4105YVM Phosphoesterase, PA-phosphatase related HH212_RS26045 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HH212_RS26050 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HH212_RS26055 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HH212_RS26070 ENOG4107S9Q Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HH212_RS26235 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HH212_RS26250 ENOG4105CAR Terminase, large subunit HH212_RS26380 ENOG4105D5G Transposase HH212_RS26405 ENOG4107RAN Peptidase, M16 HH212_RS26410 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH212_RS26415 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HH212_RS26425 ENOG4105F9F transposase HH212_RS26450 ENOG4107S1E Beta-lactamase HH212_RS26460 ENOG4105F9F transposase HH212_RS26490 ENOG4105D5G Transposase HH212_RS26510 ENOG4105C3U ABC transporter HH212_RS26515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HH212_RS26520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HH212_RS26525 ENOG4105DEF Extracellular solute-binding protein, family 5 HH212_RS26550 ENOG4105CW7 secretion protein, HlyD family HH212_RS26555 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH212_RS26600 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HH212_RS26610 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HH212_RS26730 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH212_RS26780 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH212_RS26790 ENOG4105W2Z cytochrome C, class I HH212_RS26800 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HH212_RS26820 ENOG4105HMI Membrane HH212_RS26825 ENOG4108M0I Transcriptional regulator HH212_RS26835 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HH212_RS26850 ENOG4107R4J Chloride channel HH212_RS26860 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HH212_RS26865 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HH212_RS26895 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HH212_RS26910 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH212_RS26940 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)