locus-tag	class	description
HH212_RS00140	COG2974	May be involved in recombination
HH212_RS00200	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HH212_RS00215	COG1966	Carbon starvation protein
HH212_RS00220	COG2879	small protein
HH212_RS00225	COG0784	Response regulator, receiver
HH212_RS00225	COG2205	protein histidine kinase activity
HH212_RS00225	COG5002	protein histidine kinase activity
HH212_RS00250	COG0438	transferase activity, transferring glycosyl groups
HH212_RS00255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HH212_RS00260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HH212_RS00265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HH212_RS00270	COG0840	transmembrane signaling receptor activity
HH212_RS00280	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HH212_RS00290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HH212_RS00295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HH212_RS00305	COG0612	Peptidase, M16
HH212_RS00310	COG0823	Involved in the tonB-independent uptake of proteins
HH212_RS00310	COG1506	peptidase
HH212_RS00320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HH212_RS00320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HH212_RS00350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HH212_RS00355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HH212_RS00360	COG4221	oxidoreductase activity
HH212_RS00365	COG0824	Thioesterase
HH212_RS00385	COG0823	Involved in the tonB-independent uptake of proteins
HH212_RS00395	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HH212_RS00440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HH212_RS00455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HH212_RS00505	COG3012	SEC-C Motif Domain Protein
HH212_RS00505	COG3318	Belongs to the UPF0149 family
HH212_RS00510	COG0516	GMP reductase activity
HH212_RS00510	COG0517	IMP dehydrogenase activity
HH212_RS00520	COG2205	protein histidine kinase activity
HH212_RS00525	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HH212_RS00530	COG0501	Belongs to the peptidase M48B family
HH212_RS00535	COG1162	GTPase activity
HH212_RS00540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HH212_RS00545	COG0137	argininosuccinate synthase activity
HH212_RS00550	COG4774	siderophore transport
HH212_RS00560	COG4178	(ABC) transporter
HH212_RS00565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HH212_RS00570	COG1666	GTP binding
HH212_RS00575	COG2070	2-Nitropropane dioxygenase
HH212_RS00590	COG3275	phosphorelay sensor kinase activity
HH212_RS00615	COG0583	DNA-binding transcription factor activity
HH212_RS00620	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HH212_RS00630	COG0175	sulfate reduction
HH212_RS00645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HH212_RS00645	COG1648	precorrin-2 dehydrogenase activity
HH212_RS00660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HH212_RS00665	COG0795	lipopolysaccharide-transporting ATPase activity
HH212_RS00675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HH212_RS00695	COG0708	Exodeoxyribonuclease III
HH212_RS00745	COG0626	cystathionine gamma-synthase activity
HH212_RS00750	COG0542	response to heat
HH212_RS00755	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HH212_RS00760	COG1278	Cold shock
HH212_RS00775	COG0268	Binds directly to 16S ribosomal RNA
HH212_RS00780	COG0728	peptidoglycan biosynthetic process
HH212_RS00790	COG2165	general secretion pathway protein
HH212_RS00845	COG1404	Belongs to the peptidase S8 family
HH212_RS00850	COG1404	Belongs to the peptidase S8 family
HH212_RS00870	COG0745	RESPONSE REGULATOR receiver
HH212_RS00900	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HH212_RS00905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HH212_RS00910	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HH212_RS00925	COG0438	transferase activity, transferring glycosyl groups
HH212_RS00950	COG1216	Glycosyl transferase, family 2
HH212_RS00985	COG0489	protein tyrosine kinase activity
HH212_RS00985	COG3206	protein involved in exopolysaccharide biosynthesis
HH212_RS01000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH212_RS01005	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HH212_RS01010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HH212_RS01035	COG0659	secondary active sulfate transmembrane transporter activity
HH212_RS01040	COG0745	RESPONSE REGULATOR receiver
HH212_RS01050	COG0405	Gamma-glutamyltransferase
HH212_RS01070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HH212_RS01070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HH212_RS01080	COG0563	adenylate kinase activity
HH212_RS01085	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HH212_RS01090	COG2835	tetraacyldisaccharide 4'-kinase activity
HH212_RS01095	COG1663	tetraacyldisaccharide 4'-kinase activity
HH212_RS01100	COG0848	biopolymer transport protein
HH212_RS01105	COG0811	peptide transport
HH212_RS01110	COG1570	exodeoxyribonuclease VII activity
HH212_RS01130	COG0745	RESPONSE REGULATOR receiver
HH212_RS01145	COG2205	protein histidine kinase activity
HH212_RS01165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HH212_RS01185	COG3384	dioxygenase
HH212_RS01190	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HH212_RS01210	COG0714	Associated with various cellular activities
HH212_RS01225	COG2951	lytic endotransglycosylase activity
HH212_RS01245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HH212_RS01255	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HH212_RS01265	COG0776	regulation of translation
HH212_RS01275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HH212_RS01280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HH212_RS01285	COG0287	Prephenate dehydrogenase
HH212_RS01290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HH212_RS01300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HH212_RS01320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HH212_RS01325	COG0546	phosphoglycolate phosphatase activity
HH212_RS01350	COG0693	protein deglycase activity
HH212_RS01355	COG0693	protein deglycase activity
HH212_RS01360	COG1914	H( )-stimulated, divalent metal cation uptake system
HH212_RS01385	COG1501	Belongs to the glycosyl hydrolase 31 family
HH212_RS01410	COG3590	peptidase
HH212_RS01425	COG0114	fumarate hydratase activity
HH212_RS01440	COG3220	belongs to the UPF0276 family
HH212_RS01455	COG1763	Mo-molybdopterin cofactor biosynthetic process
HH212_RS01465	COG3267	Type II secretory pathway component ExeA
HH212_RS01465	COG3409	Peptidoglycan-binding domain 1 protein
HH212_RS01500	COG2801	Transposase and inactivated derivatives
HH212_RS01535	COG0501	Belongs to the peptidase M48B family
HH212_RS01540	COG0628	permease
HH212_RS01550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HH212_RS01555	COG1472	Belongs to the glycosyl hydrolase 3 family
HH212_RS01570	COG2188	Transcriptional regulator
HH212_RS01590	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS01595	COG0612	Peptidase, M16
HH212_RS01610	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HH212_RS01620	COG0335	large ribosomal subunit rRNA binding
HH212_RS01625	COG0336	Belongs to the RNA methyltransferase TrmD family
HH212_RS01630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HH212_RS01635	COG0228	four-way junction DNA binding
HH212_RS01650	COG1960	acyl-CoA dehydrogenase activity
HH212_RS01660	COG2086	electron transfer activity
HH212_RS01665	COG0425	Belongs to the sulfur carrier protein TusA family
HH212_RS01670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HH212_RS01675	COG0584	glycerophosphoryl diester phosphodiesterase
HH212_RS01700	COG1091	dTDP-4-dehydrorhamnose reductase activity
HH212_RS01710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HH212_RS01725	COG2814	Major facilitator Superfamily
HH212_RS01745	COG0484	heat shock protein binding
HH212_RS01750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HH212_RS01790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HH212_RS01800	COG2925	Exonuclease
HH212_RS01805	COG0284	orotidine-5'-phosphate decarboxylase activity
HH212_RS01810	COG1704	LemA family
HH212_RS01825	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS01835	COG0129	dihydroxy-acid dehydratase activity
HH212_RS01860	COG3250	beta-galactosidase activity
HH212_RS01865	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HH212_RS01900	COG1538	Outer membrane efflux protein
HH212_RS01905	COG1566	PFAM secretion protein HlyD family protein
HH212_RS01915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HH212_RS01930	COG0840	transmembrane signaling receptor activity
HH212_RS01945	COG1172	Belongs to the binding-protein-dependent transport system permease family
HH212_RS01950	COG1172	Belongs to the binding-protein-dependent transport system permease family
HH212_RS01955	COG1129	ABC transporter
HH212_RS01960	COG1879	ABC-type sugar transport system periplasmic component
HH212_RS01975	COG3507	Belongs to the glycosyl hydrolase 43 family
HH212_RS01985	COG1082	Xylose isomerase domain protein TIM barrel
HH212_RS02010	COG3940	Belongs to the glycosyl hydrolase 43 family
HH212_RS02015	COG2211	Major facilitator Superfamily
HH212_RS02020	COG1629	transport
HH212_RS02020	COG4771	TonB-dependent receptor
HH212_RS02035	COG4206	TonB-dependent receptor
HH212_RS02040	COG1846	Transcriptional regulator
HH212_RS02045	COG4251	negative regulation of phosphorylation
HH212_RS02045	COG5001	Diguanylate cyclase
HH212_RS02045	COG2203	Gaf domain
HH212_RS02045	COG3706	GGDEF domain
HH212_RS02050	COG5001	Diguanylate cyclase
HH212_RS02050	COG3300	MHYT domain
HH212_RS02055	COG2080	2 iron, 2 sulfur cluster binding
HH212_RS02060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HH212_RS02065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH212_RS02070	COG5002	protein histidine kinase activity
HH212_RS02075	COG0596	Alpha beta hydrolase
HH212_RS02105	COG0281	malic enzyme
HH212_RS02105	COG0280	phosphate acetyltransferase
HH212_RS02160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HH212_RS02175	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HH212_RS02200	COG0840	transmembrane signaling receptor activity
HH212_RS02215	COG1366	Belongs to the anti-sigma-factor antagonist family
HH212_RS02220	COG2205	protein histidine kinase activity
HH212_RS02245	COG2205	protein histidine kinase activity
HH212_RS02255	COG1272	protein, Hemolysin III
HH212_RS02275	COG0784	Response regulator, receiver
HH212_RS02275	COG2205	protein histidine kinase activity
HH212_RS02305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HH212_RS02320	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS02330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HH212_RS02340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HH212_RS02370	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HH212_RS02380	COG1677	Flagellar hook-basal body complex protein FliE
HH212_RS02410	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HH212_RS02435	COG1191	sigma factor activity
HH212_RS02440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HH212_RS02475	COG1558	bacterial-type flagellum-dependent cell motility
HH212_RS02485	COG1749	Flagellar hook protein flgE
HH212_RS02495	COG4786	Flagellar basal body rod
HH212_RS02500	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HH212_RS02505	COG1706	bacterial-type flagellum-dependent cell motility
HH212_RS02515	COG1256	bacterial-type flagellum assembly
HH212_RS02520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HH212_RS02540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HH212_RS02545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HH212_RS02555	COG0779	Required for maturation of 30S ribosomal subunits
HH212_RS02565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HH212_RS02570	COG1737	Transcriptional regulator
HH212_RS02570	COG0837	glucose binding
HH212_RS02580	COG0673	inositol 2-dehydrogenase activity
HH212_RS02595	COG0601	transmembrane transport
HH212_RS02600	COG4771	TonB-dependent receptor
HH212_RS02605	COG4771	TonB-dependent receptor
HH212_RS02610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HH212_RS02635	COG0583	DNA-binding transcription factor activity
HH212_RS02650	COG0515	serine threonine protein kinase
HH212_RS02655	COG0312	modulator of DNA gyrase
HH212_RS02660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HH212_RS02670	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HH212_RS02675	COG4206	TonB-dependent receptor
HH212_RS02685	COG0024	Methionine aminopeptidase
HH212_RS02690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HH212_RS02695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HH212_RS02700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HH212_RS02710	COG4771	TonB-dependent receptor
HH212_RS02715	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HH212_RS02720	COG5006	permease, DMT superfamily
HH212_RS02735	COG0598	Magnesium transport protein CorA
HH212_RS02745	COG3852	Histidine kinase
HH212_RS02755	COG0174	glutamine synthetase
HH212_RS02790	COG3501	Rhs element vgr protein
HH212_RS02845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HH212_RS02850	COG0492	ferredoxin-NADP+ reductase activity
HH212_RS02865	COG2878	Part of a membrane complex involved in electron transport
HH212_RS02870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HH212_RS02890	COG0811	peptide transport
HH212_RS02910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH212_RS02920	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS02925	COG0277	FAD linked oxidase domain protein
HH212_RS02930	COG0546	phosphoglycolate phosphatase activity
HH212_RS02930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HH212_RS02945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HH212_RS02955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HH212_RS02960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HH212_RS02965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HH212_RS02970	COG0142	geranyltranstransferase activity
HH212_RS02985	COG0861	Integral membrane protein TerC family
HH212_RS02990	COG0243	molybdopterin cofactor binding
HH212_RS02995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HH212_RS03000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HH212_RS03000	COG2146	nitrite reductase [NAD(P)H] activity
HH212_RS03005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HH212_RS03010	COG2223	nitrite transmembrane transporter activity
HH212_RS03015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HH212_RS03020	COG3707	response regulator
HH212_RS03045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HH212_RS03055	COG0583	DNA-binding transcription factor activity
HH212_RS03065	COG0673	inositol 2-dehydrogenase activity
HH212_RS03070	COG0004	ammonium transporteR
HH212_RS03075	COG4676	Protein conserved in bacteria
HH212_RS03085	COG1595	DNA-templated transcription, initiation
HH212_RS03100	COG1953	Uracil, thiamine, allantoin
HH212_RS03125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HH212_RS03130	COG1309	transcriptional regulator
HH212_RS03160	COG3275	phosphorelay sensor kinase activity
HH212_RS03165	COG3279	Response regulator of the LytR AlgR family
HH212_RS03190	COG1012	belongs to the aldehyde dehydrogenase family
HH212_RS03195	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HH212_RS03200	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HH212_RS03205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HH212_RS03210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HH212_RS03215	COG2313	pseudouridylate synthase activity
HH212_RS03220	COG0583	DNA-binding transcription factor activity
HH212_RS03225	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HH212_RS03290	COG0737	Belongs to the 5'-nucleotidase family
HH212_RS03305	COG0402	S-adenosylhomocysteine deaminase activity
HH212_RS03315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH212_RS03330	COG2351	hydroxyisourate hydrolase activity
HH212_RS03345	COG0840	transmembrane signaling receptor activity
HH212_RS03395	COG3501	Rhs element vgr protein
HH212_RS03400	COG4302	ethanolamine ammonia-lyase activity
HH212_RS03425	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HH212_RS03435	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HH212_RS03440	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HH212_RS03460	COG2197	response regulator
HH212_RS03485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HH212_RS03490	COG0628	permease
HH212_RS03500	COG0653	protein targeting
HH212_RS03525	COG0678	peroxiredoxin activity
HH212_RS03540	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HH212_RS03545	COG1181	Belongs to the D-alanine--D-alanine ligase family
HH212_RS03550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HH212_RS03555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HH212_RS03565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HH212_RS03570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HH212_RS03575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HH212_RS03580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HH212_RS03590	COG3116	cell division
HH212_RS03595	COG0275	rRNA processing
HH212_RS03600	COG2001	Belongs to the MraZ family
HH212_RS03640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HH212_RS03670	COG2884	Cell division ATP-binding protein ftsE
HH212_RS03675	COG2177	Part of the ABC transporter FtsEX involved in
HH212_RS03680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HH212_RS03690	COG1846	Transcriptional regulator
HH212_RS03695	COG0477	Major facilitator Superfamily
HH212_RS03705	COG0405	Gamma-glutamyltransferase
HH212_RS03735	COG0583	DNA-binding transcription factor activity
HH212_RS03740	COG1253	flavin adenine dinucleotide binding
HH212_RS03795	COG3275	phosphorelay sensor kinase activity
HH212_RS03800	COG3279	Response regulator of the LytR AlgR family
HH212_RS03805	COG0628	permease
HH212_RS03810	COG1999	signal sequence binding
HH212_RS03815	COG0109	protoheme IX farnesyltransferase activity
HH212_RS03820	COG1612	heme a metabolic process
HH212_RS03850	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HH212_RS03855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HH212_RS03865	COG2226	methyltransferase
HH212_RS03885	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HH212_RS03900	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HH212_RS03905	COG4575	ribosome binding
HH212_RS03940	COG0386	Belongs to the glutathione peroxidase family
HH212_RS03950	COG0596	Alpha beta hydrolase
HH212_RS03965	COG1082	Xylose isomerase domain protein TIM barrel
HH212_RS03975	COG4221	oxidoreductase activity
HH212_RS03980	COG2207	Transcriptional regulator
HH212_RS03985	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS04005	COG0247	lactate metabolic process
HH212_RS04010	COG0277	FAD linked oxidase domain protein
HH212_RS04015	COG0277	FAD linked oxidase domain protein
HH212_RS04020	COG2096	Adenosyltransferase
HH212_RS04025	COG0457	Tetratricopeptide repeat
HH212_RS04025	COG0705	Rhomboid family
HH212_RS04030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HH212_RS04035	COG0142	geranyltranstransferase activity
HH212_RS04040	COG1722	exodeoxyribonuclease VII activity
HH212_RS04060	COG4773	Receptor
HH212_RS04080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HH212_RS04080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HH212_RS04090	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HH212_RS04100	COG0210	DNA helicase
HH212_RS04110	COG3590	peptidase
HH212_RS04120	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HH212_RS04125	COG0745	RESPONSE REGULATOR receiver
HH212_RS04130	COG0525	valine-tRNA ligase activity
HH212_RS04155	COG2255	four-way junction helicase activity
HH212_RS04160	COG0632	four-way junction helicase activity
HH212_RS04165	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HH212_RS04170	COG0138	bifunctional purine biosynthesis protein purh
HH212_RS04175	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HH212_RS04180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HH212_RS04190	COG1881	PFAM PEBP family protein
HH212_RS04195	COG1490	D-aminoacyl-tRNA deacylase activity
HH212_RS04210	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HH212_RS04220	COG0316	Belongs to the HesB IscA family
HH212_RS04230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HH212_RS04235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HH212_RS04240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HH212_RS04250	COG4555	ABC transporter
HH212_RS04260	COG1765	OsmC-like protein
HH212_RS04265	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HH212_RS04275	COG1131	(ABC) transporter
HH212_RS04295	COG2922	Belongs to the Smg family
HH212_RS04300	COG0758	DNA mediated transformation
HH212_RS04315	COG0242	peptide deformylase activity
HH212_RS04320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HH212_RS04370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HH212_RS04380	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HH212_RS04385	COG0121	glutamine amidotransferase
HH212_RS04400	COG2204	response regulator
HH212_RS04405	COG5000	phosphorelay sensor kinase activity
HH212_RS04415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HH212_RS04415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HH212_RS04420	COG0018	arginyl-trna synthetase
HH212_RS04430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HH212_RS04440	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HH212_RS04450	COG0753	catalase activity
HH212_RS04470	COG4702	Belongs to the UPF0303 family
HH212_RS04475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HH212_RS04480	COG0772	Belongs to the SEDS family
HH212_RS04485	COG0768	penicillin binding
HH212_RS04500	COG1077	Cell shape determining protein MreB Mrl
HH212_RS04510	COG0154	amidase activity
HH212_RS04515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HH212_RS04520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HH212_RS04525	COG0708	Exodeoxyribonuclease III
HH212_RS04535	COG0564	pseudouridine synthase activity
HH212_RS04540	COG0501	Belongs to the peptidase M48B family
HH212_RS04545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HH212_RS04545	COG2813	Specifically methylates the guanine in position
HH212_RS04550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HH212_RS04555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HH212_RS04560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HH212_RS04570	COG0189	ligase activity
HH212_RS04585	COG0004	ammonium transporteR
HH212_RS04590	COG0347	Belongs to the P(II) protein family
HH212_RS04610	COG0606	chelatase, subunit chli
HH212_RS04670	COG0473	3-isopropylmalate dehydrogenase activity
HH212_RS04675	COG0583	DNA-binding transcription factor activity
HH212_RS04720	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HH212_RS04725	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HH212_RS04735	COG4206	TonB-dependent receptor
HH212_RS04745	COG1120	ATPase activity
HH212_RS04755	COG1797	cobyrinic acid a,c-diamide synthase activity
HH212_RS04775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HH212_RS04780	COG1492	cobalamin metabolic process
HH212_RS04825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HH212_RS04840	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HH212_RS04850	COG2967	ApaG domain
HH212_RS04855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HH212_RS04860	COG0546	phosphoglycolate phosphatase activity
HH212_RS04875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HH212_RS04880	COG0134	indole-3-glycerol-phosphate synthase activity
HH212_RS04900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HH212_RS04905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HH212_RS04935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HH212_RS04955	COG2205	protein histidine kinase activity
HH212_RS04975	COG3590	peptidase
HH212_RS04980	COG2824	Alkylphosphonate utilization operon protein PhnA
HH212_RS04985	COG2340	Cysteine-rich secretory protein family
HH212_RS04990	COG1764	response to oxidative stress
HH212_RS04995	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HH212_RS05005	COG0596	Alpha beta hydrolase
HH212_RS05010	COG0840	transmembrane signaling receptor activity
HH212_RS05015	COG1607	acyl-coa hydrolase
HH212_RS05060	COG1652	LysM domain
HH212_RS05080	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HH212_RS05085	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HH212_RS05090	COG1684	flagellar biosynthetic protein fliR
HH212_RS05095	COG1987	bacterial-type flagellum assembly
HH212_RS05120	COG1338	Plays a role in the flagellum-specific transport system
HH212_RS05130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HH212_RS05145	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HH212_RS05160	COG1157	protein secretion by the type III secretion system
HH212_RS05180	COG1677	Flagellar hook-basal body complex protein FliE
HH212_RS05195	COG1706	bacterial-type flagellum-dependent cell motility
HH212_RS05200	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HH212_RS05210	COG4786	Flagellar basal body rod
HH212_RS05215	COG4786	Flagellar basal body rod
HH212_RS05230	COG0156	8-amino-7-oxononanoate synthase activity
HH212_RS05235	COG0318	PFAM AMP-dependent synthetase and ligase
HH212_RS05250	COG1902	pentaerythritol trinitrate reductase activity
HH212_RS05255	COG0583	DNA-binding transcription factor activity
HH212_RS05260	COG3040	lipid binding
HH212_RS05265	COG2207	Transcriptional regulator
HH212_RS05265	COG3708	Transcriptional regulator
HH212_RS05270	COG3122	Protein conserved in bacteria
HH212_RS05285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HH212_RS05310	COG0840	transmembrane signaling receptor activity
HH212_RS05315	COG4294	response to UV
HH212_RS05320	COG0667	Aldo Keto reductase
HH212_RS05325	COG3781	membrane
HH212_RS05335	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HH212_RS05340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HH212_RS05350	COG1335	isochorismatase
HH212_RS05365	COG3108	Peptidase M15
HH212_RS05400	COG3437	response regulator, receiver
HH212_RS05400	COG0784	Response regulator, receiver
HH212_RS05410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HH212_RS05415	COG4191	Histidine kinase
HH212_RS05415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HH212_RS05435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HH212_RS05440	COG0729	surface antigen
HH212_RS05485	COG1472	Belongs to the glycosyl hydrolase 3 family
HH212_RS05500	COG2223	nitrite transmembrane transporter activity
HH212_RS05620	COG0519	Catalyzes the synthesis of GMP from XMP
HH212_RS05635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HH212_RS05670	COG0793	Belongs to the peptidase S41A family
HH212_RS05685	COG4206	TonB-dependent receptor
HH212_RS05690	COG0438	transferase activity, transferring glycosyl groups
HH212_RS05695	COG0438	transferase activity, transferring glycosyl groups
HH212_RS05700	COG1024	Enoyl-CoA hydratase
HH212_RS05705	COG0183	Belongs to the thiolase family
HH212_RS05710	COG1024	Enoyl-CoA hydratase
HH212_RS05710	COG1250	3-hydroxyacyl-CoA dehydrogenase
HH212_RS05715	COG1960	acyl-CoA dehydrogenase activity
HH212_RS05730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HH212_RS05735	COG3568	Endonuclease Exonuclease Phosphatase
HH212_RS05745	COG1116	anion transmembrane transporter activity
HH212_RS05750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HH212_RS05755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HH212_RS05760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HH212_RS05765	COG0431	NADPH-dependent FMN reductase
HH212_RS05770	COG3706	GGDEF domain
HH212_RS05775	COG0494	nUDIX hydrolase
HH212_RS05780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HH212_RS05800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HH212_RS05815	COG2226	methyltransferase
HH212_RS05825	COG1278	Cold shock
HH212_RS05845	COG1238	metal cluster binding
HH212_RS05850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HH212_RS05855	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HH212_RS05855	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HH212_RS05865	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HH212_RS05870	COG1660	Displays ATPase and GTPase activities
HH212_RS05880	COG1024	Enoyl-CoA hydratase
HH212_RS05885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HH212_RS05890	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HH212_RS05895	COG1137	ATPase activity
HH212_RS05910	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HH212_RS05925	COG3706	GGDEF domain
HH212_RS05940	COG0633	Ferredoxin
HH212_RS05940	COG3217	Mosc domain protein beta barrel domain protein
HH212_RS05945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HH212_RS05955	COG2022	thiamine diphosphate biosynthetic process
HH212_RS05960	COG0352	thiamine-phosphate diphosphorylase activity
HH212_RS05960	COG0351	phosphomethylpyrimidine kinase
HH212_RS05960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HH212_RS05965	COG0352	thiamine-phosphate diphosphorylase activity
HH212_RS05980	COG1982	Orn Lys Arg decarboxylase major
HH212_RS05990	COG0697	spore germination
HH212_RS06015	COG0012	GTP binding
HH212_RS06035	COG3437	response regulator, receiver
HH212_RS06040	COG0193	aminoacyl-tRNA hydrolase activity
HH212_RS06045	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HH212_RS06050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HH212_RS06060	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HH212_RS06075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HH212_RS06085	COG1194	a g-specific adenine glycosylase
HH212_RS06100	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HH212_RS06145	COG1965	Belongs to the frataxin family
HH212_RS06165	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HH212_RS06170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HH212_RS06175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HH212_RS06180	COG1333	cytochrome c biogenesis protein
HH212_RS06210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HH212_RS06220	COG0745	RESPONSE REGULATOR receiver
HH212_RS06230	COG4232	protein-disulfide reductase activity
HH212_RS06235	COG0203	ribosomal protein L17
HH212_RS06240	COG0202	RNA polymerase activity
HH212_RS06245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HH212_RS06250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HH212_RS06255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HH212_RS06260	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HH212_RS06265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HH212_RS06270	COG0201	protein transport
HH212_RS06275	COG0200	Binds to the 23S rRNA
HH212_RS06280	COG1841	ribosomal large subunit assembly
HH212_RS06285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HH212_RS06290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HH212_RS06295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HH212_RS06300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HH212_RS06305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HH212_RS06310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HH212_RS06315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HH212_RS06320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HH212_RS06325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HH212_RS06330	COG0255	Belongs to the universal ribosomal protein uL29 family
HH212_RS06335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HH212_RS06340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HH212_RS06345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HH212_RS06350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HH212_RS06355	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HH212_RS06360	COG0089	rRNA binding
HH212_RS06365	COG0088	Forms part of the polypeptide exit tunnel
HH212_RS06370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HH212_RS06380	COG0668	transmembrane transport
HH212_RS06385	COG1609	Transcriptional regulator
HH212_RS06395	COG0051	transcription antitermination factor activity, RNA binding
HH212_RS06400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HH212_RS06405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HH212_RS06410	COG0049	tRNA binding
HH212_RS06415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HH212_RS06420	COG2194	sulfuric ester hydrolase activity
HH212_RS06425	COG1881	PFAM PEBP family protein
HH212_RS06440	COG1136	(ABC) transporter
HH212_RS06445	COG0577	efflux transmembrane transporter activity
HH212_RS06445	COG1136	(ABC) transporter
HH212_RS06450	COG1136	(ABC) transporter
HH212_RS06450	COG0577	efflux transmembrane transporter activity
HH212_RS06460	COG3852	Histidine kinase
HH212_RS06465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH212_RS06470	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HH212_RS06475	COG2080	2 iron, 2 sulfur cluster binding
HH212_RS06480	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HH212_RS06510	COG0714	Associated with various cellular activities
HH212_RS06520	COG0312	modulator of DNA gyrase
HH212_RS06530	COG0312	modulator of DNA gyrase
HH212_RS06550	COG2226	methyltransferase
HH212_RS06555	COG3550	peptidyl-serine autophosphorylation
HH212_RS06575	COG1396	sequence-specific DNA binding
HH212_RS06580	COG4692	amylo-alpha-1,6-glucosidase activity
HH212_RS06585	COG3459	Glycosyltransferase 36 associated
HH212_RS06590	COG1104	cysteine desulfurase activity
HH212_RS06595	COG1522	sequence-specific DNA binding
HH212_RS06620	COG3851	Histidine kinase
HH212_RS06630	COG2201	protein-glutamate methylesterase activity
HH212_RS06650	COG2205	protein histidine kinase activity
HH212_RS06660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HH212_RS06665	COG0085	RNA polymerase activity
HH212_RS06670	COG0222	ribosome binding
HH212_RS06675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HH212_RS06680	COG0081	regulation of translation
HH212_RS06685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HH212_RS06730	COG0745	RESPONSE REGULATOR receiver
HH212_RS06735	COG0484	heat shock protein binding
HH212_RS06745	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS06755	COG0037	tRNA processing
HH212_RS06790	COG1522	sequence-specific DNA binding
HH212_RS06795	COG2755	lipolytic protein G-D-S-L family
HH212_RS06800	COG3345	alpha-galactosidase
HH212_RS06810	COG1472	Belongs to the glycosyl hydrolase 3 family
HH212_RS06820	COG1609	Transcriptional regulator
HH212_RS06840	COG0617	tRNA 3'-terminal CCA addition
HH212_RS06870	COG1950	PFAM Membrane protein of
HH212_RS06875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HH212_RS06880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HH212_RS06890	COG1560	Kdo2-lipid A biosynthetic process
HH212_RS06895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HH212_RS06905	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HH212_RS06915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HH212_RS06920	COG0523	cobalamin synthesis protein
HH212_RS06935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HH212_RS06940	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HH212_RS07015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HH212_RS07020	COG0793	Belongs to the peptidase S41A family
HH212_RS07025	COG4942	peptidase
HH212_RS07030	COG0588	phosphoglycerate mutase activity
HH212_RS07035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HH212_RS07045	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HH212_RS07075	COG1970	mechanosensitive ion channel activity
HH212_RS07080	COG0723	plastoquinol--plastocyanin reductase activity
HH212_RS07085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HH212_RS07090	COG2857	Cytochrome c1
HH212_RS07095	COG0625	glutathione transferase activity
HH212_RS07100	COG2969	positive regulation of protein catabolic process
HH212_RS07155	COG0430	RNA-3'-phosphate cyclase activity
HH212_RS07245	COG0789	Transcriptional regulator
HH212_RS07250	COG0431	NADPH-dependent FMN reductase
HH212_RS07260	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HH212_RS07265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HH212_RS07295	COG4644	lycopene metabolic process
HH212_RS07300	COG1196	nuclear chromosome segregation
HH212_RS07315	COG4650	regulator
HH212_RS07360	COG4964	Belongs to the GSP D family
HH212_RS07390	COG3706	GGDEF domain
HH212_RS07405	COG1294	oxidase, subunit
HH212_RS07415	COG1703	isobutyryl-CoA mutase activity
HH212_RS07415	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HH212_RS07415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HH212_RS07435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HH212_RS07480	COG1596	polysaccharide export
HH212_RS07495	COG0489	protein tyrosine kinase activity
HH212_RS07505	COG3267	Type II secretory pathway component ExeA
HH212_RS07505	COG3409	Peptidoglycan-binding domain 1 protein
HH212_RS07530	COG0438	transferase activity, transferring glycosyl groups
HH212_RS07540	COG0297	glycogen (starch) synthase activity
HH212_RS07545	COG1215	transferase activity, transferring glycosyl groups
HH212_RS07600	COG2204	response regulator
HH212_RS07605	COG3290	protein histidine kinase activity
HH212_RS07610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HH212_RS07620	COG3245	cytochrome
HH212_RS07650	COG3590	peptidase
HH212_RS07675	COG0793	Belongs to the peptidase S41A family
HH212_RS07725	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS07730	COG0183	Belongs to the thiolase family
HH212_RS07735	COG0850	regulation of cytokinetic process
HH212_RS07740	COG2894	cell division
HH212_RS07745	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HH212_RS07760	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HH212_RS07765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HH212_RS07770	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HH212_RS07775	COG2890	protein-(glutamine-N5) methyltransferase activity
HH212_RS07785	COG2918	glutathione biosynthetic process
HH212_RS07795	COG2153	protein acetylation
HH212_RS07800	COG0477	Major facilitator Superfamily
HH212_RS07810	COG4191	Histidine kinase
HH212_RS07820	COG0545	Peptidyl-prolyl cis-trans isomerase
HH212_RS07825	COG3158	transport of potassium into the cell
HH212_RS07835	COG0488	(ABC) transporter
HH212_RS07885	COG0006	proline dipeptidase activity
HH212_RS07920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HH212_RS07940	COG1309	transcriptional regulator
HH212_RS07945	COG0512	Glutamine amidotransferase of anthranilate synthase
HH212_RS07945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HH212_RS07960	COG2326	polyphosphate kinase activity
HH212_RS07965	COG1832	CoA-binding protein
HH212_RS07970	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HH212_RS07975	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HH212_RS07980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HH212_RS07985	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HH212_RS07990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HH212_RS07995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HH212_RS08005	COG0356	it plays a direct role in the translocation of protons across the membrane
HH212_RS08020	COG1475	DNA binding
HH212_RS08025	COG1192	Involved in chromosome partitioning
HH212_RS08030	COG0357	Ribosomal RNA small subunit methyltransferase G
HH212_RS08035	COG0445	tRNA wobble uridine modification
HH212_RS08045	COG0596	Alpha beta hydrolase
HH212_RS08050	COG4214	carbohydrate transport
HH212_RS08085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HH212_RS08090	COG0686	Belongs to the AlaDH PNT family
HH212_RS08095	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HH212_RS08095	COG0506	proline dehydrogenase activity
HH212_RS08095	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HH212_RS08130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HH212_RS08135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HH212_RS08140	COG0742	ribosomal rna small subunit methyltransferase
HH212_RS08150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HH212_RS08155	COG1522	sequence-specific DNA binding
HH212_RS08165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HH212_RS08220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HH212_RS08285	COG2308	Evidence 4 Homologs of previously reported genes of
HH212_RS08325	COG1752	Esterase of the alpha-beta hydrolase superfamily
HH212_RS08370	COG1064	alcohol dehydrogenase
HH212_RS08380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HH212_RS08400	COG2354	Protein conserved in bacteria
HH212_RS08410	COG0776	regulation of translation
HH212_RS08415	COG1280	lysine exporter protein (LysE YggA)
HH212_RS08430	COG3311	Transcriptional regulator
HH212_RS08435	COG2921	Belongs to the UPF0250 family
HH212_RS08440	COG0321	lipoyl(octanoyl) transferase activity
HH212_RS08445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HH212_RS08455	COG3383	formate dehydrogenase (NAD+) activity
HH212_RS08470	COG1910	domain protein
HH212_RS08490	COG2823	Periplasmic or secreted lipoprotein
HH212_RS08495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HH212_RS08500	COG0792	nuclease activity
HH212_RS08505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HH212_RS08525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HH212_RS08535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HH212_RS08540	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HH212_RS08545	COG0156	8-amino-7-oxononanoate synthase activity
HH212_RS08555	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HH212_RS08560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HH212_RS08565	COG3012	SEC-C Motif Domain Protein
HH212_RS08575	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HH212_RS08585	COG1649	PFAM Uncharacterised BCR, COG1649
HH212_RS08595	COG3023	N-Acetylmuramoyl-L-alanine amidase
HH212_RS08605	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HH212_RS08615	COG2027	D-alanyl-D-alanine carboxypeptidase
HH212_RS08620	COG2715	membrane protein required for spore maturation
HH212_RS08625	COG0747	negative chemotaxis
HH212_RS08635	COG1619	proteins homologs of microcin C7 resistance protein MccF
HH212_RS08655	COG1960	acyl-CoA dehydrogenase activity
HH212_RS08670	COG1960	acyl-CoA dehydrogenase activity
HH212_RS08675	COG0789	Transcriptional regulator
HH212_RS08700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HH212_RS08710	COG2183	response to ionizing radiation
HH212_RS08715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HH212_RS08725	COG0745	RESPONSE REGULATOR receiver
HH212_RS08750	COG0069	glutamate synthase activity
HH212_RS08750	COG0067	glutamate synthase
HH212_RS08750	COG0070	glutamate synthase
HH212_RS08760	COG1127	ABC transporter
HH212_RS08765	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HH212_RS08770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HH212_RS08775	COG2853	Lipoprotein
HH212_RS08790	COG1131	(ABC) transporter
HH212_RS08795	COG0842	Transport permease protein
HH212_RS08800	COG0271	Belongs to the BolA IbaG family
HH212_RS08805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HH212_RS08810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HH212_RS08815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HH212_RS08825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HH212_RS08830	COG0131	Imidazoleglycerol-phosphate dehydratase
HH212_RS08840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HH212_RS08845	COG0107	imidazoleglycerol-phosphate synthase activity
HH212_RS08850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HH212_RS08855	COG0140	phosphoribosyl-ATP diphosphatase activity
HH212_RS08865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HH212_RS08870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HH212_RS08875	COG0805	protein transport
HH212_RS08890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HH212_RS08900	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HH212_RS08905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HH212_RS08965	COG4772	TonB-dependent receptor
HH212_RS08970	COG1012	belongs to the aldehyde dehydrogenase family
HH212_RS08980	COG3284	Transcriptional regulator
HH212_RS09015	COG0210	DNA helicase
HH212_RS09045	COG0339	signal peptide processing
HH212_RS09050	COG0339	signal peptide processing
HH212_RS09055	COG4628	conserved protein (DUF2132)
HH212_RS09065	COG1032	radical SAM domain protein
HH212_RS09075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HH212_RS09080	COG3706	GGDEF domain
HH212_RS09100	COG4771	TonB-dependent receptor
HH212_RS09105	COG1404	Belongs to the peptidase S8 family
HH212_RS09110	COG1404	Belongs to the peptidase S8 family
HH212_RS09115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HH212_RS09120	COG2974	May be involved in recombination
HH212_RS09145	COG1404	Belongs to the peptidase S8 family
HH212_RS09145	COG4935	Belongs to the peptidase S8 family
HH212_RS09150	COG0753	catalase activity
HH212_RS09170	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HH212_RS09200	COG0629	single-stranded DNA binding
HH212_RS09205	COG5507	3-demethylubiquinone-9 3-methyltransferase
HH212_RS09210	COG0310	cobalt ion transport
HH212_RS09225	COG1122	ATPase activity
HH212_RS09245	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HH212_RS09275	COG3411	Ferredoxin
HH212_RS09285	COG2267	carboxylic ester hydrolase activity
HH212_RS09295	COG0657	acetylesterase activity
HH212_RS09295	COG2755	lipolytic protein G-D-S-L family
HH212_RS09305	COG2610	gluconate transmembrane transporter activity
HH212_RS09315	COG3265	gluconokinase activity
HH212_RS09320	COG2723	6-phospho-beta-galactosidase activity
HH212_RS09330	COG0840	transmembrane signaling receptor activity
HH212_RS09355	COG2192	nodulation
HH212_RS09360	COG2816	NAD+ diphosphatase activity
HH212_RS09370	COG0302	gtp cyclohydrolase
HH212_RS09380	COG0667	Aldo Keto reductase
HH212_RS09390	COG2080	2 iron, 2 sulfur cluster binding
HH212_RS09395	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HH212_RS09400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH212_RS09410	COG1566	PFAM secretion protein HlyD family protein
HH212_RS09420	COG1289	transmembrane transporter activity
HH212_RS09430	COG0546	phosphoglycolate phosphatase activity
HH212_RS09435	COG0584	glycerophosphoryl diester phosphodiesterase
HH212_RS09490	COG0592	DNA-directed DNA polymerase activity
HH212_RS09495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HH212_RS09500	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HH212_RS09505	COG0594	ribonuclease P activity
HH212_RS09510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HH212_RS09515	COG0706	membrane insertase activity
HH212_RS09520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HH212_RS09525	COG0583	DNA-binding transcription factor activity
HH212_RS09530	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS09555	COG1183	phosphatidylcholine synthase activity
HH212_RS09565	COG4989	oxidoreductase activity
HH212_RS09570	COG1686	Belongs to the peptidase S11 family
HH212_RS09575	COG2945	thiolester hydrolase activity
HH212_RS09600	COG1127	ABC transporter
HH212_RS09605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HH212_RS09610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HH212_RS09640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH212_RS09645	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HH212_RS09650	COG2080	2 iron, 2 sulfur cluster binding
HH212_RS09655	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HH212_RS09660	COG3791	Glutathione-dependent formaldehyde-activating
HH212_RS09675	COG2010	Cytochrome c
HH212_RS09705	COG3284	Transcriptional regulator
HH212_RS09735	COG2366	antibiotic biosynthetic process
HH212_RS09740	COG0477	Major facilitator Superfamily
HH212_RS09745	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HH212_RS09750	COG2084	Dehydrogenase
HH212_RS09760	COG1473	amidohydrolase
HH212_RS09765	COG0243	molybdopterin cofactor binding
HH212_RS09775	COG0318	PFAM AMP-dependent synthetase and ligase
HH212_RS09780	COG0318	PFAM AMP-dependent synthetase and ligase
HH212_RS09790	COG3540	Alkaline phosphatase
HH212_RS09800	COG5265	(ABC) transporter
HH212_RS09815	COG1301	dicarboxylic acid transport
HH212_RS09820	COG1126	abc transporter atp-binding protein
HH212_RS09840	COG0418	dihydroorotase activity
HH212_RS09890	COG3209	COG3209 Rhs family protein
HH212_RS09900	COG3501	Rhs element vgr protein
HH212_RS09920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HH212_RS09925	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HH212_RS09930	COG0343	queuine tRNA-ribosyltransferase activity
HH212_RS09935	COG1862	Preprotein translocase
HH212_RS09940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HH212_RS09945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HH212_RS09970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HH212_RS09985	COG1012	belongs to the aldehyde dehydrogenase family
HH212_RS09990	COG3724	N-succinylarginine dihydrolase activity
HH212_RS09995	COG2902	Dehydrogenase
HH212_RS10000	COG2988	succinylglutamate desuccinylase activity
HH212_RS10015	COG4948	Mandelate Racemase Muconate Lactonizing
HH212_RS10020	COG1902	pentaerythritol trinitrate reductase activity
HH212_RS10035	COG1959	2 iron, 2 sulfur cluster binding
HH212_RS10040	COG0531	amino acid
HH212_RS10055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HH212_RS10060	COG2261	transglycosylase associated protein
HH212_RS10075	COG2353	YceI-like domain
HH212_RS10095	COG0625	glutathione transferase activity
HH212_RS10100	COG1609	Transcriptional regulator
HH212_RS10120	COG2211	Major facilitator Superfamily
HH212_RS10175	COG0840	transmembrane signaling receptor activity
HH212_RS10185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HH212_RS10200	COG2203	Gaf domain
HH212_RS10200	COG2199	diguanylate cyclase activity
HH212_RS10200	COG2200	EAL domain
HH212_RS10205	COG0482	sulfurtransferase activity
HH212_RS10230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HH212_RS10235	COG0006	proline dipeptidase activity
HH212_RS10245	COG3178	'Phosphotransferase
HH212_RS10250	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HH212_RS10255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HH212_RS10260	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HH212_RS10265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HH212_RS10295	COG0596	Alpha beta hydrolase
HH212_RS10300	COG0735	belongs to the Fur family
HH212_RS10305	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HH212_RS10310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HH212_RS10320	COG0495	leucyl-tRNA aminoacylation
HH212_RS10335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HH212_RS10350	COG2814	Major facilitator Superfamily
HH212_RS10370	COG3852	Histidine kinase
HH212_RS10395	COG1573	uracil-dna glycosylase
HH212_RS10410	COG1045	serine acetyltransferase
HH212_RS10440	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HH212_RS10445	COG0514	ATP-dependent DNA helicase (RecQ)
HH212_RS10450	COG1968	undecaprenyl-diphosphatase activity
HH212_RS10465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HH212_RS10470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HH212_RS10480	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HH212_RS10485	COG0346	lactoylglutathione lyase activity
HH212_RS10490	COG1764	response to oxidative stress
HH212_RS10510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HH212_RS10515	COG0497	DNA recombination
HH212_RS10520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HH212_RS10530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HH212_RS10535	COG0443	Heat shock 70 kDa protein
HH212_RS10540	COG0484	heat shock protein binding
HH212_RS10545	COG0288	reversible hydration of carbon dioxide
HH212_RS10565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HH212_RS10570	COG0174	glutamine synthetase
HH212_RS10590	COG3275	phosphorelay sensor kinase activity
HH212_RS10605	COG2223	nitrite transmembrane transporter activity
HH212_RS10615	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HH212_RS10630	COG0617	tRNA 3'-terminal CCA addition
HH212_RS10640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HH212_RS10655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HH212_RS10665	COG0642	Histidine kinase
HH212_RS10675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HH212_RS10680	COG2137	regulation of response to DNA damage stimulus
HH212_RS10690	COG0045	succinate-CoA ligase (ADP-forming) activity
HH212_RS10695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HH212_RS10700	COG4969	Belongs to the N-Me-Phe pilin family
HH212_RS10710	COG1506	peptidase
HH212_RS10710	COG0823	Involved in the tonB-independent uptake of proteins
HH212_RS10715	COG0840	transmembrane signaling receptor activity
HH212_RS10720	COG0315	cyclic pyranopterin monophosphate synthase activity
HH212_RS10725	COG4783	chaperone-mediated protein folding
HH212_RS10735	COG0429	hydrolase of the alpha beta-hydrolase fold
HH212_RS10755	COG0126	phosphoglycerate kinase activity
HH212_RS10760	COG0469	pyruvate kinase activity
HH212_RS10770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HH212_RS10775	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HH212_RS10780	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HH212_RS10785	COG0009	L-threonylcarbamoyladenylate synthase
HH212_RS10805	COG1960	acyl-CoA dehydrogenase activity
HH212_RS10810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HH212_RS10815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HH212_RS10820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HH212_RS10825	COG0259	pyridoxamine-phosphate oxidase activity
HH212_RS10830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HH212_RS10850	COG0640	Transcriptional regulator
HH212_RS10855	COG0612	Peptidase, M16
HH212_RS10860	COG0612	Peptidase, M16
HH212_RS10870	COG1546	Belongs to the CinA family
HH212_RS10905	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HH212_RS10975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HH212_RS10980	COG1111	helicase
HH212_RS10980	COG1205	dead DEAH box helicase
HH212_RS11020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HH212_RS11045	COG0582	viral genome integration into host DNA
HH212_RS11070	COG0254	rRNA binding
HH212_RS11075	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HH212_RS11080	COG3118	belongs to the thioredoxin family
HH212_RS11085	COG2188	Transcriptional regulator
HH212_RS11090	COG2169	Transcriptional regulator
HH212_RS11090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HH212_RS11100	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HH212_RS11105	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HH212_RS11110	COG2986	histidine ammonia-lyase
HH212_RS11120	COG0402	S-adenosylhomocysteine deaminase activity
HH212_RS11130	COG1228	amidohydrolase
HH212_RS11135	COG1174	glycine betaine transport
HH212_RS11175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HH212_RS11200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HH212_RS11215	COG2094	Belongs to the DNA glycosylase MPG family
HH212_RS11240	COG0179	Fumarylacetoacetate (FAA) hydrolase
HH212_RS11245	COG3250	beta-galactosidase activity
HH212_RS11250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HH212_RS11260	COG1902	pentaerythritol trinitrate reductase activity
HH212_RS11270	COG0400	carboxylic ester hydrolase activity
HH212_RS11275	COG0521	Mo-molybdopterin cofactor biosynthetic process
HH212_RS11285	COG0312	modulator of DNA gyrase
HH212_RS11300	COG2866	Carboxypeptidase
HH212_RS11310	COG3396	Phenylacetate-CoA oxygenase
HH212_RS11315	COG3460	Phenylacetate-CoA oxygenase
HH212_RS11320	COG3396	Phenylacetate-CoA oxygenase
HH212_RS11325	COG2151	metal-sulfur cluster biosynthetic enzyme
HH212_RS11330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HH212_RS11335	COG1024	Enoyl-CoA hydratase
HH212_RS11340	COG1250	3-hydroxyacyl-CoA dehydrogenase
HH212_RS11345	COG2050	protein possibly involved in aromatic compounds catabolism
HH212_RS11355	COG0183	Belongs to the thiolase family
HH212_RS11365	COG2030	dehydratase
HH212_RS11365	COG1012	belongs to the aldehyde dehydrogenase family
HH212_RS11380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HH212_RS11385	COG0165	Argininosuccinate lyase
HH212_RS11425	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HH212_RS11460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HH212_RS11475	COG0659	secondary active sulfate transmembrane transporter activity
HH212_RS11490	COG0442	prolyl-tRNA aminoacylation
HH212_RS11495	COG0741	lytic transglycosylase activity
HH212_RS11500	COG0583	DNA-binding transcription factor activity
HH212_RS11515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HH212_RS11520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HH212_RS11525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HH212_RS11560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HH212_RS11565	COG0438	transferase activity, transferring glycosyl groups
HH212_RS11570	COG0297	glycogen (starch) synthase activity
HH212_RS11585	COG0762	integral membrane protein
HH212_RS11590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HH212_RS11605	COG2264	protein methyltransferase activity
HH212_RS11610	COG0439	Biotin carboxylase
HH212_RS11615	COG0511	ligase activity, forming carbon-carbon bonds
HH212_RS11620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HH212_RS11625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HH212_RS11635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HH212_RS11640	COG3150	esterase
HH212_RS11645	COG3161	chorismate lyase activity
HH212_RS11650	COG0557	exoribonuclease II activity
HH212_RS11660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HH212_RS11665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HH212_RS11675	COG4773	Receptor
HH212_RS11685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HH212_RS11690	COG0351	phosphomethylpyrimidine kinase
HH212_RS11695	COG1773	rubredoxin
HH212_RS11715	COG0840	transmembrane signaling receptor activity
HH212_RS11720	COG2198	Histidine kinase
HH212_RS11720	COG0784	Response regulator, receiver
HH212_RS11720	COG0643	Histidine kinase
HH212_RS11725	COG0415	Belongs to the DNA photolyase family
HH212_RS11730	COG1678	Uncharacterized ACR, COG1678
HH212_RS11735	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HH212_RS11740	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HH212_RS11745	COG0540	Belongs to the ATCase OTCase family
HH212_RS11760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HH212_RS11780	COG0859	PFAM glycosyl transferase family 9
HH212_RS11805	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HH212_RS11810	COG0751	glycine-tRNA ligase activity
HH212_RS11815	COG0752	glycyl-tRNA synthetase alpha subunit
HH212_RS11820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HH212_RS11825	COG4535	Mg2 and Co2 transporter CorC
HH212_RS11830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HH212_RS11835	COG1702	phosphate starvation-inducible protein PhoH
HH212_RS11840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HH212_RS11860	COG0625	glutathione transferase activity
HH212_RS11880	COG4651	solute:proton antiporter activity
HH212_RS11880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HH212_RS11885	COG2733	membrane
HH212_RS11895	COG4948	Mandelate Racemase Muconate Lactonizing
HH212_RS11900	COG0583	DNA-binding transcription factor activity
HH212_RS11910	COG1363	Peptidase, m42
HH212_RS11925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HH212_RS11930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HH212_RS11940	COG0586	Pfam SNARE associated Golgi protein
HH212_RS11955	COG0860	N-Acetylmuramoyl-L-alanine amidase
HH212_RS11960	COG0802	atpase or kinase
HH212_RS11965	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HH212_RS11975	COG4566	intracellular signal transduction
HH212_RS11995	COG4974	Belongs to the 'phage' integrase family
HH212_RS12015	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HH212_RS12075	COG1674	ftsk spoiiie
HH212_RS12080	COG1061	Type III restriction enzyme res subunit
HH212_RS12110	COG0640	Transcriptional regulator
HH212_RS12130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HH212_RS12140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HH212_RS12145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HH212_RS12150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HH212_RS12155	COG2081	HI0933 family
HH212_RS12160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HH212_RS12175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HH212_RS12200	COG3501	Rhs element vgr protein
HH212_RS12250	COG2124	cytochrome p450
HH212_RS12255	COG4191	Histidine kinase
HH212_RS12255	COG0784	Response regulator, receiver
HH212_RS12275	COG0513	Belongs to the DEAD box helicase family
HH212_RS12280	COG4191	Histidine kinase
HH212_RS12280	COG0784	Response regulator, receiver
HH212_RS12305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HH212_RS12315	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HH212_RS12370	COG1132	(ABC) transporter
HH212_RS12390	COG0318	PFAM AMP-dependent synthetase and ligase
HH212_RS12400	COG1530	ribonuclease E activity
HH212_RS12405	COG0424	maF-like protein
HH212_RS12410	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HH212_RS12415	COG0799	negative regulation of ribosome biogenesis
HH212_RS12420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HH212_RS12425	COG0408	coproporphyrinogen oxidase activity
HH212_RS12440	COG0151	Belongs to the GarS family
HH212_RS12445	COG0217	transcriptional regulatory protein
HH212_RS12455	COG1803	Methylglyoxal synthase
HH212_RS12475	COG0308	aminopeptidase N
HH212_RS12480	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HH212_RS12515	COG0840	transmembrane signaling receptor activity
HH212_RS12565	COG3706	GGDEF domain
HH212_RS12650	COG3501	Rhs element vgr protein
HH212_RS12655	COG3706	GGDEF domain
HH212_RS12660	COG1132	(ABC) transporter
HH212_RS12665	COG1132	(ABC) transporter
HH212_RS12675	COG0402	S-adenosylhomocysteine deaminase activity
HH212_RS12685	COG0840	transmembrane signaling receptor activity
HH212_RS12695	COG0366	Alpha amylase catalytic
HH212_RS12720	COG0033	Phosphoglucomutase
HH212_RS12725	COG0366	Alpha amylase catalytic
HH212_RS12730	COG2267	carboxylic ester hydrolase activity
HH212_RS12750	COG1404	Belongs to the peptidase S8 family
HH212_RS12770	COG3104	oligopeptide transport
HH212_RS12775	COG0366	Alpha amylase catalytic
HH212_RS12780	COG1737	Transcriptional regulator
HH212_RS12780	COG0837	glucose binding
HH212_RS12790	COG1064	alcohol dehydrogenase
HH212_RS12800	COG0459	protein refolding
HH212_RS12805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HH212_RS12830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HH212_RS12835	COG0583	DNA-binding transcription factor activity
HH212_RS12875	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HH212_RS12880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HH212_RS12885	COG0508	dehydrogenase complex catalyzes the overall conversion of
HH212_RS12890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HH212_RS12905	COG2084	Dehydrogenase
HH212_RS12925	COG3275	phosphorelay sensor kinase activity
HH212_RS12970	COG0840	transmembrane signaling receptor activity
HH212_RS12980	COG2823	Periplasmic or secreted lipoprotein
HH212_RS12990	COG2814	Major facilitator Superfamily
HH212_RS12995	COG1739	Uncharacterized protein family UPF0029
HH212_RS13025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HH212_RS13040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HH212_RS13045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HH212_RS13045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HH212_RS13050	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HH212_RS13050	COG3264	Mechanosensitive ion channel
HH212_RS13070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HH212_RS13075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HH212_RS13080	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HH212_RS13085	COG2003	Belongs to the UPF0758 family
HH212_RS13090	COG1047	Peptidyl-prolyl cis-trans
HH212_RS13100	COG0559	Belongs to the binding-protein-dependent transport system permease family
HH212_RS13145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HH212_RS13150	COG0450	alkyl hydroperoxide reductase
HH212_RS13155	COG0730	response to heat
HH212_RS13160	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HH212_RS13165	COG4208	sulfate ABC transporter
HH212_RS13170	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HH212_RS13175	COG0583	DNA-binding transcription factor activity
HH212_RS13180	COG0667	Aldo Keto reductase
HH212_RS13185	COG0167	dihydroorotate dehydrogenase activity
HH212_RS13190	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HH212_RS13195	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HH212_RS13225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HH212_RS13235	COG4783	chaperone-mediated protein folding
HH212_RS13240	COG0756	dUTP diphosphatase activity
HH212_RS13245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HH212_RS13250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HH212_RS13255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HH212_RS13260	COG0196	riboflavin kinase activity
HH212_RS13290	COG2719	SpoVR family
HH212_RS13295	COG2718	Belongs to the UPF0229 family
HH212_RS13300	COG2766	serine protein kinase
HH212_RS13305	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HH212_RS13310	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HH212_RS13315	COG2346	COG2346, Truncated hemoglobins
HH212_RS13325	COG0303	'Molybdopterin
HH212_RS13330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HH212_RS13335	COG1959	2 iron, 2 sulfur cluster binding
HH212_RS13340	COG0492	ferredoxin-NADP+ reductase activity
HH212_RS13345	COG1530	ribonuclease E activity
HH212_RS13375	COG1187	pseudouridine synthase activity
HH212_RS13380	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HH212_RS13405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HH212_RS13425	COG1215	transferase activity, transferring glycosyl groups
HH212_RS13445	COG1091	dTDP-4-dehydrorhamnose reductase activity
HH212_RS13470	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HH212_RS13475	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HH212_RS13490	COG1191	sigma factor activity
HH212_RS13495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HH212_RS13500	COG1360	Flagellar Motor Protein
HH212_RS13510	COG4104	PAAR repeat-containing protein
HH212_RS13550	COG1558	bacterial-type flagellum-dependent cell motility
HH212_RS13565	COG4787	bacterial-type flagellum-dependent cell motility
HH212_RS13575	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HH212_RS13580	COG1706	bacterial-type flagellum-dependent cell motility
HH212_RS13585	COG3951	Flagellar rod assembly protein muramidase FlgJ
HH212_RS13585	COG1705	Flagellar rod assembly protein muramidase FlgJ
HH212_RS13600	COG1684	flagellar biosynthetic protein fliR
HH212_RS13620	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HH212_RS13625	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HH212_RS13630	COG1580	Controls the rotational direction of flagella during chemotaxis
HH212_RS13645	COG1157	protein secretion by the type III secretion system
HH212_RS13655	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HH212_RS13665	COG1677	Flagellar hook-basal body complex protein FliE
HH212_RS13675	COG3685	Protein conserved in bacteria
HH212_RS13685	COG0395	ABC-type sugar transport system, permease component
HH212_RS13690	COG1116	anion transmembrane transporter activity
HH212_RS13695	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HH212_RS13700	COG2257	FlhB HrpN YscU SpaS Family
HH212_RS13720	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HH212_RS13720	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HH212_RS13720	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HH212_RS13770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HH212_RS13775	COG1758	RNA polymerase activity
HH212_RS13785	COG1561	YicC-like family, N-terminal region
HH212_RS13790	COG2815	serine threonine protein kinase
HH212_RS13790	COG0515	serine threonine protein kinase
HH212_RS13795	COG0631	protein serine/threonine phosphatase activity
HH212_RS13810	COG0156	8-amino-7-oxononanoate synthase activity
HH212_RS13850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HH212_RS13855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HH212_RS13860	COG3275	phosphorelay sensor kinase activity
HH212_RS13890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HH212_RS13905	COG2070	2-Nitropropane dioxygenase
HH212_RS13915	COG0840	transmembrane signaling receptor activity
HH212_RS13925	COG1956	GAF domain-containing protein
HH212_RS13930	COG0596	Alpha beta hydrolase
HH212_RS13965	COG2814	Major facilitator Superfamily
HH212_RS13985	COG1737	Transcriptional regulator
HH212_RS13990	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HH212_RS14015	COG3501	Rhs element vgr protein
HH212_RS14075	COG0166	Belongs to the GPI family
HH212_RS14085	COG0800	Aldolase
HH212_RS14105	COG2197	response regulator
HH212_RS14110	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HH212_RS14125	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HH212_RS14130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HH212_RS14130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HH212_RS14135	COG1643	Atp-dependent helicase
HH212_RS14150	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS14155	COG0625	glutathione transferase activity
HH212_RS14175	COG0443	Heat shock 70 kDa protein
HH212_RS14180	COG0443	Heat shock 70 kDa protein
HH212_RS14250	COG0583	DNA-binding transcription factor activity
HH212_RS14255	COG0702	epimerase
HH212_RS14275	COG0071	Belongs to the small heat shock protein (HSP20) family
HH212_RS14280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HH212_RS14290	COG0642	Histidine kinase
HH212_RS14305	COG0463	Glycosyl transferase, family 2
HH212_RS14365	COG0587	DNA-directed DNA polymerase activity
HH212_RS14370	COG1473	amidohydrolase
HH212_RS14390	COG4269	membrane
HH212_RS14395	COG0504	CTP synthase activity
HH212_RS14400	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HH212_RS14405	COG0148	phosphopyruvate hydratase activity
HH212_RS14410	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HH212_RS14435	COG0300	oxidoreductase activity
HH212_RS14440	COG0783	Belongs to the Dps family
HH212_RS14445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HH212_RS14455	COG2267	carboxylic ester hydrolase activity
HH212_RS14460	COG0613	PHP domain protein
HH212_RS14465	COG0009	L-threonylcarbamoyladenylate synthase
HH212_RS14470	COG1994	Peptidase M50
HH212_RS14480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HH212_RS14485	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HH212_RS14500	COG2850	peptidyl-arginine hydroxylation
HH212_RS14505	COG1047	Peptidyl-prolyl cis-trans
HH212_RS14515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HH212_RS14530	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HH212_RS14530	COG2755	lipolytic protein G-D-S-L family
HH212_RS14540	COG1181	Belongs to the D-alanine--D-alanine ligase family
HH212_RS14540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HH212_RS14545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HH212_RS14545	COG1181	Belongs to the D-alanine--D-alanine ligase family
HH212_RS14550	COG1132	(ABC) transporter
HH212_RS14625	COG1819	glycosyl
HH212_RS14640	COG0784	Response regulator, receiver
HH212_RS14640	COG2198	Histidine kinase
HH212_RS14640	COG2205	protein histidine kinase activity
HH212_RS14645	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HH212_RS14655	COG5002	protein histidine kinase activity
HH212_RS14670	COG0514	ATP-dependent DNA helicase (RecQ)
HH212_RS14675	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HH212_RS14675	COG1793	dna ligase
HH212_RS14680	COG1793	dna ligase
HH212_RS14680	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HH212_RS14685	COG1201	RNA secondary structure unwinding
HH212_RS14700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HH212_RS14715	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HH212_RS14720	COG0784	Response regulator, receiver
HH212_RS14720	COG0643	Histidine kinase
HH212_RS14720	COG2198	Histidine kinase
HH212_RS14725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HH212_RS14735	COG0066	3-isopropylmalate dehydratase activity
HH212_RS14740	COG0473	3-isopropylmalate dehydrogenase activity
HH212_RS14745	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HH212_RS14760	COG0101	tRNA pseudouridine synthase activity
HH212_RS14765	COG0135	phosphoribosylanthranilate isomerase activity
HH212_RS14770	COG0133	tryptophan synthase activity
HH212_RS14775	COG0159	tryptophan synthase activity
HH212_RS14785	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HH212_RS14790	COG0285	dihydrofolate synthase activity
HH212_RS14800	COG1286	toxin biosynthetic process
HH212_RS14820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HH212_RS14825	COG0360	Binds together with S18 to 16S ribosomal RNA
HH212_RS14830	COG2965	DNA replication, synthesis of RNA primer
HH212_RS14835	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HH212_RS14840	COG0359	binds to the 23S rRNA
HH212_RS14845	COG0305	Participates in initiation and elongation during chromosome replication
HH212_RS14855	COG0306	phosphate transporter
HH212_RS14875	COG0583	DNA-binding transcription factor activity
HH212_RS14880	COG0667	Aldo Keto reductase
HH212_RS14885	COG1234	tRNA 3'-trailer cleavage
HH212_RS14890	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HH212_RS14905	COG1940	carbohydrate kinase activity
HH212_RS14930	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HH212_RS14935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HH212_RS14945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH212_RS14945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HH212_RS14950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HH212_RS14950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH212_RS14955	COG0463	Glycosyl transferase, family 2
HH212_RS14960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HH212_RS14965	COG2076	Multidrug Resistance protein
HH212_RS14980	COG0436	Aminotransferase
HH212_RS14995	COG0642	Histidine kinase
HH212_RS15025	COG3842	ATPase activity
HH212_RS15035	COG0477	Major facilitator Superfamily
HH212_RS15060	COG2201	protein-glutamate methylesterase activity
HH212_RS15070	COG0835	chemotaxis
HH212_RS15090	COG0745	RESPONSE REGULATOR receiver
HH212_RS15135	COG0859	PFAM glycosyl transferase family 9
HH212_RS15140	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HH212_RS15145	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS15150	COG0297	glycogen (starch) synthase activity
HH212_RS15175	COG2866	Carboxypeptidase
HH212_RS15180	COG2954	triphosphatase activity
HH212_RS15190	COG0784	Response regulator, receiver
HH212_RS15190	COG2205	protein histidine kinase activity
HH212_RS15200	COG3128	pkhd-type hydroxylase
HH212_RS15205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HH212_RS15230	COG2009	succinate dehydrogenase
HH212_RS15235	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HH212_RS15240	COG1053	succinate dehydrogenase
HH212_RS15245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HH212_RS15250	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HH212_RS15255	COG0372	Belongs to the citrate synthase family
HH212_RS15290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HH212_RS15300	COG2323	membrane
HH212_RS15310	COG0745	RESPONSE REGULATOR receiver
HH212_RS15315	COG2205	protein histidine kinase activity
HH212_RS15330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HH212_RS15355	COG0567	Dehydrogenase, E1 component
HH212_RS15360	COG0508	dehydrogenase complex catalyzes the overall conversion of
HH212_RS15370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HH212_RS15375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HH212_RS15385	COG0631	protein serine/threonine phosphatase activity
HH212_RS15395	COG1199	ATP-dependent helicase activity
HH212_RS15410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HH212_RS15415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HH212_RS15430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HH212_RS15435	COG2205	protein histidine kinase activity
HH212_RS15450	COG0670	Belongs to the BI1 family
HH212_RS15455	COG0105	UTP biosynthetic process
HH212_RS15460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HH212_RS15475	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HH212_RS15480	COG0124	histidyl-tRNA synthetase
HH212_RS15495	COG1160	GTP binding
HH212_RS15500	COG1923	regulation of RNA biosynthetic process
HH212_RS15505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HH212_RS15510	COG0330	HflC and HflK could
HH212_RS15515	COG0330	HflC and HflK could
HH212_RS15520	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HH212_RS15525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HH212_RS15530	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HH212_RS15535	COG0840	transmembrane signaling receptor activity
HH212_RS15540	COG2095	MarC family integral membrane protein
HH212_RS15570	COG0556	nucleotide-excision repair
HH212_RS15590	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HH212_RS15610	COG2814	Major facilitator Superfamily
HH212_RS15620	COG0784	Response regulator, receiver
HH212_RS15620	COG4191	Histidine kinase
HH212_RS15625	COG0784	Response regulator, receiver
HH212_RS15630	COG4251	negative regulation of phosphorylation
HH212_RS15635	COG0784	Response regulator, receiver
HH212_RS15635	COG4191	Histidine kinase
HH212_RS15665	COG1538	Outer membrane efflux protein
HH212_RS15695	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HH212_RS15705	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HH212_RS15725	COG0625	glutathione transferase activity
HH212_RS15740	COG1104	cysteine desulfurase activity
HH212_RS15745	COG0822	iron-sulfur transferase activity
HH212_RS15750	COG0316	Belongs to the HesB IscA family
HH212_RS15755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HH212_RS15760	COG0443	Heat shock 70 kDa protein
HH212_RS15765	COG0633	Ferredoxin
HH212_RS15770	COG2975	iron-sulfur cluster assembly
HH212_RS15780	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HH212_RS15815	COG0028	Belongs to the TPP enzyme family
HH212_RS15820	COG0440	acetolactate synthase activity
HH212_RS15825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HH212_RS15835	COG1183	phosphatidylcholine synthase activity
HH212_RS15855	COG1914	H( )-stimulated, divalent metal cation uptake system
HH212_RS15860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HH212_RS15865	COG1185	polyribonucleotide nucleotidyltransferase activity
HH212_RS15875	COG1366	Belongs to the anti-sigma-factor antagonist family
HH212_RS15880	COG1366	Belongs to the anti-sigma-factor antagonist family
HH212_RS15885	COG2172	sigma factor antagonist activity
HH212_RS15895	COG2205	protein histidine kinase activity
HH212_RS15900	COG2205	protein histidine kinase activity
HH212_RS15900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HH212_RS15915	COG0612	Peptidase, M16
HH212_RS15935	COG3507	Belongs to the glycosyl hydrolase 43 family
HH212_RS15950	COG0149	triose-phosphate isomerase activity
HH212_RS15965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HH212_RS15970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HH212_RS15975	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HH212_RS15980	COG0649	NAD binding
HH212_RS15985	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HH212_RS15995	COG1034	ATP synthesis coupled electron transport
HH212_RS16000	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HH212_RS16005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HH212_RS16015	COG0713	ATP synthesis coupled electron transport
HH212_RS16030	COG1007	ATP synthesis coupled electron transport
HH212_RS16040	COG0494	nUDIX hydrolase
HH212_RS16050	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HH212_RS16055	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HH212_RS16080	COG0431	NADPH-dependent FMN reductase
HH212_RS16085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HH212_RS16095	COG0251	oxidation-reduction process
HH212_RS16105	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HH212_RS16120	COG3279	Response regulator of the LytR AlgR family
HH212_RS16125	COG3275	phosphorelay sensor kinase activity
HH212_RS16130	COG2205	protein histidine kinase activity
HH212_RS16135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HH212_RS16150	COG0745	RESPONSE REGULATOR receiver
HH212_RS16160	COG0784	Response regulator, receiver
HH212_RS16160	COG4191	Histidine kinase
HH212_RS16175	COG4191	Histidine kinase
HH212_RS16175	COG0784	Response regulator, receiver
HH212_RS16185	COG2205	protein histidine kinase activity
HH212_RS16195	COG4145	pantothenate transmembrane transporter activity
HH212_RS16200	COG0616	signal peptide processing
HH212_RS16205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HH212_RS16225	COG2076	Multidrug Resistance protein
HH212_RS16235	COG3591	Belongs to the peptidase S1B family
HH212_RS16235	COG4990	cell redox homeostasis
HH212_RS16240	COG4191	Histidine kinase
HH212_RS16250	COG1136	(ABC) transporter
HH212_RS16250	COG0577	efflux transmembrane transporter activity
HH212_RS16255	COG0577	efflux transmembrane transporter activity
HH212_RS16255	COG1136	(ABC) transporter
HH212_RS16260	COG1136	(ABC) transporter
HH212_RS16265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HH212_RS16320	COG5001	Diguanylate cyclase
HH212_RS16320	COG5002	protein histidine kinase activity
HH212_RS16330	COG2205	protein histidine kinase activity
HH212_RS16335	COG0745	RESPONSE REGULATOR receiver
HH212_RS16355	COG0835	chemotaxis
HH212_RS16360	COG0488	(ABC) transporter
HH212_RS16365	COG2890	protein-(glutamine-N5) methyltransferase activity
HH212_RS16370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HH212_RS16375	COG1393	Belongs to the ArsC family
HH212_RS16420	COG2171	N-acyltransferase activity
HH212_RS16425	COG0436	Aminotransferase
HH212_RS16440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HH212_RS16450	COG0697	spore germination
HH212_RS16455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HH212_RS16460	COG4941	Belongs to the sigma-70 factor family
HH212_RS16465	COG3795	YCII-related domain
HH212_RS16470	COG3795	YCII-related domain
HH212_RS16480	COG0326	Molecular chaperone. Has ATPase activity
HH212_RS16495	COG3483	tryptophan 2,3-dioxygenase activity
HH212_RS16515	COG2226	methyltransferase
HH212_RS16525	COG1360	Flagellar Motor Protein
HH212_RS16535	COG0745	RESPONSE REGULATOR receiver
HH212_RS16540	COG2198	Histidine kinase
HH212_RS16540	COG0643	Histidine kinase
HH212_RS16545	COG0835	chemotaxis
HH212_RS16550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HH212_RS16555	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HH212_RS16560	COG2201	protein-glutamate methylesterase activity
HH212_RS16565	COG0745	RESPONSE REGULATOR receiver
HH212_RS16570	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HH212_RS16575	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HH212_RS16585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HH212_RS16605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HH212_RS16605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HH212_RS16610	COG0489	protein tyrosine kinase activity
HH212_RS16615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HH212_RS16630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HH212_RS16675	COG1404	Belongs to the peptidase S8 family
HH212_RS16695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HH212_RS16705	COG0154	amidase activity
HH212_RS16715	COG0477	Major facilitator Superfamily
HH212_RS16730	COG0513	Belongs to the DEAD box helicase family
HH212_RS16745	COG2813	Specifically methylates the guanine in position
HH212_RS16760	COG0420	3'-5' exonuclease activity
HH212_RS16765	COG3214	Protein conserved in bacteria
HH212_RS16785	COG0314	molybdopterin synthase activity
HH212_RS16790	COG4682	membrane
HH212_RS16795	COG0038	chloride channel
HH212_RS16800	COG0542	response to heat
HH212_RS16805	COG2224	Isocitrate lyase
HH212_RS16810	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HH212_RS16815	COG2202	Pas domain
HH212_RS16815	COG2200	EAL domain
HH212_RS16815	COG2199	diguanylate cyclase activity
HH212_RS16825	COG0424	maF-like protein
HH212_RS16835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HH212_RS16840	COG0416	fatty acid biosynthetic process
HH212_RS16845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HH212_RS16860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HH212_RS16865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HH212_RS16885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HH212_RS16895	COG0481	GTPase activity
HH212_RS16915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HH212_RS16920	COG1381	Involved in DNA repair and RecF pathway recombination
HH212_RS16925	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HH212_RS16930	COG0736	holo-[acyl-carrier-protein] synthase activity
HH212_RS16935	COG0322	excinuclease ABC activity
HH212_RS16975	COG2207	Transcriptional regulator
HH212_RS17000	COG3550	peptidyl-serine autophosphorylation
HH212_RS17030	COG3916	Acyl-homoserine-lactone synthase
HH212_RS17080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HH212_RS17100	COG2977	Belongs to the P-Pant transferase superfamily
HH212_RS17115	COG1136	(ABC) transporter
HH212_RS17135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HH212_RS17145	COG2814	Major facilitator Superfamily
HH212_RS17150	COG1609	Transcriptional regulator
HH212_RS17155	COG0415	Belongs to the DNA photolyase family
HH212_RS17160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HH212_RS17180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HH212_RS17185	COG0366	Alpha amylase catalytic
HH212_RS17190	COG0058	SHG alpha-glucan phosphorylase activity
HH212_RS17195	COG0297	glycogen (starch) synthase activity
HH212_RS17205	COG1523	belongs to the glycosyl hydrolase 13 family
HH212_RS17280	COG3501	Rhs element vgr protein
HH212_RS17305	COG1301	dicarboxylic acid transport
HH212_RS17335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HH212_RS17370	COG1104	cysteine desulfurase activity
HH212_RS17375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HH212_RS17380	COG0583	DNA-binding transcription factor activity
HH212_RS17385	COG1944	ATP diphosphatase activity
HH212_RS17400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HH212_RS17435	COG4172	Belongs to the ABC transporter superfamily
HH212_RS17440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HH212_RS17445	COG0601	transmembrane transport
HH212_RS17450	COG0747	negative chemotaxis
HH212_RS17455	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HH212_RS17460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HH212_RS17485	COG1304	FMN binding
HH212_RS17495	COG4566	intracellular signal transduction
HH212_RS17505	COG0477	Major facilitator Superfamily
HH212_RS17530	COG4771	TonB-dependent receptor
HH212_RS17545	COG1131	(ABC) transporter
HH212_RS17555	COG3437	response regulator, receiver
HH212_RS17575	COG4771	TonB-dependent receptor
HH212_RS17605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HH212_RS17610	COG0840	transmembrane signaling receptor activity
HH212_RS17615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HH212_RS17645	COG0456	acetyltransferase
HH212_RS17670	COG1271	oxidase subunit
HH212_RS17675	COG1294	oxidase, subunit
HH212_RS17690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HH212_RS17705	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HH212_RS17710	COG1595	DNA-templated transcription, initiation
HH212_RS17715	COG0740	serine-type endopeptidase activity
HH212_RS17725	COG5002	protein histidine kinase activity
HH212_RS17755	COG4191	Histidine kinase
HH212_RS17755	COG0784	Response regulator, receiver
HH212_RS17795	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HH212_RS17800	COG0025	NhaP-type Na H and K H
HH212_RS17810	COG2205	protein histidine kinase activity
HH212_RS17815	COG0436	Aminotransferase
HH212_RS17825	COG2264	protein methyltransferase activity
HH212_RS17870	COG0210	DNA helicase
HH212_RS17875	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HH212_RS17905	COG0784	Response regulator, receiver
HH212_RS17905	COG2205	protein histidine kinase activity
HH212_RS17920	COG1505	serine-type exopeptidase activity
HH212_RS17925	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HH212_RS17930	COG1074	ATP-dependent DNA helicase activity
HH212_RS17935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HH212_RS17940	COG5002	protein histidine kinase activity
HH212_RS17960	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HH212_RS17965	COG2153	protein acetylation
HH212_RS17975	COG2155	Conserved Protein
HH212_RS17995	COG5001	Diguanylate cyclase
HH212_RS17995	COG3300	MHYT domain
HH212_RS18005	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS18035	COG0501	Belongs to the peptidase M48B family
HH212_RS18060	COG1301	dicarboxylic acid transport
HH212_RS18085	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS18095	COG0251	oxidation-reduction process
HH212_RS18100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HH212_RS18120	COG1285	pathogenesis
HH212_RS18130	COG0492	ferredoxin-NADP+ reductase activity
HH212_RS18135	COG1230	cation diffusion facilitator family transporter
HH212_RS18145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HH212_RS18150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HH212_RS18155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HH212_RS18160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HH212_RS18165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HH212_RS18170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HH212_RS18170	COG0072	phenylalanine-tRNA ligase activity
HH212_RS18175	COG0776	regulation of translation
HH212_RS18215	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HH212_RS18215	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HH212_RS18220	COG0509	glycine decarboxylation via glycine cleavage system
HH212_RS18225	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HH212_RS18260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HH212_RS18265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HH212_RS18270	COG0242	peptide deformylase activity
HH212_RS18290	COG1127	ABC transporter
HH212_RS18295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HH212_RS18335	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HH212_RS18340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HH212_RS18340	COG2205	protein histidine kinase activity
HH212_RS18350	COG0436	Aminotransferase
HH212_RS18375	COG3104	oligopeptide transport
HH212_RS18385	COG1187	pseudouridine synthase activity
HH212_RS18390	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HH212_RS18395	COG0024	Methionine aminopeptidase
HH212_RS18400	COG0052	Belongs to the universal ribosomal protein uS2 family
HH212_RS18405	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HH212_RS18410	COG0528	UMP kinase activity
HH212_RS18415	COG0233	cytoplasmic translational termination
HH212_RS18420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HH212_RS18425	COG0575	Belongs to the CDS family
HH212_RS18430	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HH212_RS18435	COG0750	zinc metalloprotease
HH212_RS18450	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HH212_RS18455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HH212_RS18460	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HH212_RS18465	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HH212_RS18470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HH212_RS18475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HH212_RS18485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HH212_RS18540	COG0681	Belongs to the peptidase S26 family
HH212_RS18545	COG2814	Major facilitator Superfamily
HH212_RS18550	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HH212_RS18555	COG2867	negative regulation of translational initiation
HH212_RS18560	COG2914	Belongs to the UPF0125 (RnfH) family
HH212_RS18570	COG0517	IMP dehydrogenase activity
HH212_RS18570	COG0516	GMP reductase activity
HH212_RS18575	COG0519	Catalyzes the synthesis of GMP from XMP
HH212_RS18575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HH212_RS18595	COG2826	transposase and inactivated derivatives, IS30 family
HH212_RS18650	COG2361	Protein of unknown function DUF86
HH212_RS18675	COG2133	pyrroloquinoline quinone binding
HH212_RS18695	COG2271	Major facilitator Superfamily
HH212_RS18700	COG0583	DNA-binding transcription factor activity
HH212_RS18765	COG4676	Protein conserved in bacteria
HH212_RS18770	COG5445	Predicted secreted protein (DUF2300)
HH212_RS18775	COG2373	Large extracellular alpha-helical protein
HH212_RS18785	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HH212_RS18790	COG0402	S-adenosylhomocysteine deaminase activity
HH212_RS18805	COG0778	Nitroreductase
HH212_RS18810	COG2897	thiosulfate sulfurtransferase activity
HH212_RS18830	COG3250	beta-galactosidase activity
HH212_RS18835	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HH212_RS18840	COG1657	PFAM Prenyltransferase squalene oxidase
HH212_RS18890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HH212_RS18900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH212_RS18925	COG3706	GGDEF domain
HH212_RS18925	COG4251	negative regulation of phosphorylation
HH212_RS18925	COG2203	Gaf domain
HH212_RS18925	COG5001	Diguanylate cyclase
HH212_RS18940	COG2755	lipolytic protein G-D-S-L family
HH212_RS18945	COG4771	TonB-dependent receptor
HH212_RS18950	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HH212_RS18970	COG2186	Transcriptional regulator
HH212_RS18975	COG0667	Aldo Keto reductase
HH212_RS18985	COG1085	galactose-1-phosphate uridylyltransferase
HH212_RS18990	COG1621	beta-fructofuranosidase activity
HH212_RS19035	COG0437	4 iron, 4 sulfur cluster binding
HH212_RS19070	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HH212_RS19075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HH212_RS19110	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS19115	COG4206	TonB-dependent receptor
HH212_RS19120	COG0028	Belongs to the TPP enzyme family
HH212_RS19150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HH212_RS19155	COG0583	DNA-binding transcription factor activity
HH212_RS19160	COG2910	NAD(P)H-binding
HH212_RS19170	COG2130	NADP-dependent
HH212_RS19245	COG1609	Transcriptional regulator
HH212_RS19280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HH212_RS19300	COG5002	protein histidine kinase activity
HH212_RS19325	COG4191	Histidine kinase
HH212_RS19325	COG0784	Response regulator, receiver
HH212_RS19345	COG0745	RESPONSE REGULATOR receiver
HH212_RS19390	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HH212_RS19395	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HH212_RS19400	COG0835	chemotaxis
HH212_RS19405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH212_RS19415	COG2271	Major facilitator Superfamily
HH212_RS19420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HH212_RS19425	COG2188	Transcriptional regulator
HH212_RS19430	COG0546	phosphoglycolate phosphatase activity
HH212_RS19435	COG0025	NhaP-type Na H and K H
HH212_RS19450	COG3250	beta-galactosidase activity
HH212_RS19465	COG4172	Belongs to the ABC transporter superfamily
HH212_RS19470	COG0601	transmembrane transport
HH212_RS19475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HH212_RS19495	COG0583	DNA-binding transcription factor activity
HH212_RS19565	COG3940	Belongs to the glycosyl hydrolase 43 family
HH212_RS19600	COG4249	Peptidase C14 caspase catalytic subunit p20
HH212_RS19600	COG2319	Wd-40 repeat
HH212_RS19620	COG1172	Belongs to the binding-protein-dependent transport system permease family
HH212_RS19630	COG1129	ABC transporter
HH212_RS19635	COG1879	ABC-type sugar transport system periplasmic component
HH212_RS19645	COG3347	Dehydrogenase
HH212_RS19645	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS19650	COG4952	isomerase
HH212_RS19655	COG3940	Belongs to the glycosyl hydrolase 43 family
HH212_RS19660	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HH212_RS19665	COG3254	rhamnose metabolic process
HH212_RS19685	COG3386	PFAM SMP-30 Gluconolaconase
HH212_RS19695	COG0179	Fumarylacetoacetate (FAA) hydrolase
HH212_RS19720	COG2755	lipolytic protein G-D-S-L family
HH212_RS19735	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HH212_RS19750	COG2755	lipolytic protein G-D-S-L family
HH212_RS19755	COG4733	cellulase activity
HH212_RS19760	COG4677	pectinesterase activity
HH212_RS19765	COG3401	FG-GAP repeat protein
HH212_RS19785	COG0604	alcohol dehydrogenase
HH212_RS19855	COG2833	Protein of unknown function (DUF455)
HH212_RS19860	COG0417	DNA replication proofreading
HH212_RS19865	COG4676	Protein conserved in bacteria
HH212_RS19880	COG0456	acetyltransferase
HH212_RS19915	COG1064	alcohol dehydrogenase
HH212_RS19930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HH212_RS19935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HH212_RS19950	COG0835	chemotaxis
HH212_RS19950	COG0784	Response regulator, receiver
HH212_RS19955	COG3501	Rhs element vgr protein
HH212_RS19985	COG3179	chitinase
HH212_RS19990	COG3501	Rhs element vgr protein
HH212_RS20075	COG3942	CHAP domain
HH212_RS20075	COG1388	LysM domain
HH212_RS20080	COG3501	Rhs element vgr protein
HH212_RS20125	COG3706	GGDEF domain
HH212_RS20145	COG3706	GGDEF domain
HH212_RS20145	COG2203	Gaf domain
HH212_RS20145	COG5001	Diguanylate cyclase
HH212_RS20145	COG4251	negative regulation of phosphorylation
HH212_RS20190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HH212_RS20205	COG4771	TonB-dependent receptor
HH212_RS20220	COG2271	Major facilitator Superfamily
HH212_RS20225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HH212_RS20235	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS20240	COG1609	Transcriptional regulator
HH212_RS20250	COG4771	TonB-dependent receptor
HH212_RS20270	COG0778	Nitroreductase
HH212_RS20295	COG2382	esterase
HH212_RS20295	COG3507	Belongs to the glycosyl hydrolase 43 family
HH212_RS20295	COG3693	PFAM glycoside hydrolase, family 10
HH212_RS20300	COG3661	Belongs to the glycosyl hydrolase 67 family
HH212_RS20310	COG1472	Belongs to the glycosyl hydrolase 3 family
HH212_RS20330	COG0129	dihydroxy-acid dehydratase activity
HH212_RS20360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH212_RS20395	COG1501	Belongs to the glycosyl hydrolase 31 family
HH212_RS20425	COG4702	Belongs to the UPF0303 family
HH212_RS20445	COG0784	Response regulator, receiver
HH212_RS20445	COG4191	Histidine kinase
HH212_RS20450	COG3291	Pkd domain containing protein
HH212_RS20465	COG2175	clavaminate synthase activity
HH212_RS20475	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HH212_RS20480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HH212_RS20485	COG0840	transmembrane signaling receptor activity
HH212_RS20495	COG3300	MHYT domain
HH212_RS20495	COG5001	Diguanylate cyclase
HH212_RS20505	COG2010	Cytochrome c
HH212_RS20505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH212_RS20510	COG2080	2 iron, 2 sulfur cluster binding
HH212_RS20515	COG2010	Cytochrome c
HH212_RS20515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH212_RS20520	COG0840	transmembrane signaling receptor activity
HH212_RS20570	COG2080	2 iron, 2 sulfur cluster binding
HH212_RS20575	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HH212_RS20580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH212_RS20585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HH212_RS20595	COG2205	protein histidine kinase activity
HH212_RS20620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HH212_RS20655	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HH212_RS20705	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HH212_RS20710	COG3766	membrane
HH212_RS20730	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HH212_RS20750	COG0667	Aldo Keto reductase
HH212_RS20760	COG1522	sequence-specific DNA binding
HH212_RS20845	COG1309	transcriptional regulator
HH212_RS20850	COG1597	lipid kinase activity
HH212_RS20855	COG5001	Diguanylate cyclase
HH212_RS20855	COG3300	MHYT domain
HH212_RS20865	COG1609	Transcriptional regulator
HH212_RS20875	COG0655	NAD(P)H dehydrogenase (quinone) activity
HH212_RS20890	COG1175	transmembrane transport
HH212_RS20895	COG0395	ABC-type sugar transport system, permease component
HH212_RS20900	COG3842	ATPase activity
HH212_RS20905	COG1609	Transcriptional regulator
HH212_RS20910	COG3501	Rhs element vgr protein
HH212_RS20935	COG1472	Belongs to the glycosyl hydrolase 3 family
HH212_RS20940	COG0837	glucose binding
HH212_RS20945	COG1971	Probably functions as a manganese efflux pump
HH212_RS20955	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HH212_RS20955	COG2755	lipolytic protein G-D-S-L family
HH212_RS21045	COG2814	Major facilitator Superfamily
HH212_RS21065	COG1305	Transglutaminase-like
HH212_RS21070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HH212_RS21075	COG3250	beta-galactosidase activity
HH212_RS21080	COG2205	protein histidine kinase activity
HH212_RS21090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HH212_RS21090	COG0475	glutathione-regulated potassium exporter activity
HH212_RS21135	COG0708	Exodeoxyribonuclease III
HH212_RS21140	COG1501	Belongs to the glycosyl hydrolase 31 family
HH212_RS21165	COG0386	Belongs to the glutathione peroxidase family
HH212_RS21185	COG1113	amino acid transport
HH212_RS21200	COG1253	flavin adenine dinucleotide binding
HH212_RS21205	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HH212_RS21220	COG1380	Effector of murein hydrolase LrgA
HH212_RS21225	COG1346	cytolysis
HH212_RS21235	COG0477	Major facilitator Superfamily
HH212_RS21240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HH212_RS21245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HH212_RS21250	COG1845	cytochrome c oxidase, subunit III
HH212_RS21255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HH212_RS21270	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HH212_RS21340	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS21345	COG0668	transmembrane transport
HH212_RS21350	COG0823	Involved in the tonB-independent uptake of proteins
HH212_RS21355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HH212_RS21360	COG0477	Major facilitator Superfamily
HH212_RS21390	COG2197	response regulator
HH212_RS21395	COG5001	Diguanylate cyclase
HH212_RS21400	COG0656	L-ascorbic acid biosynthetic process
HH212_RS21415	COG2252	PERMEase
HH212_RS21425	COG1904	glucuronate isomerase
HH212_RS21430	COG2721	sulfolactate sulfo-lyase activity
HH212_RS21435	COG0246	Mannitol dehydrogenase
HH212_RS21440	COG2271	Major facilitator Superfamily
HH212_RS21450	COG5434	Belongs to the glycosyl hydrolase 28 family
HH212_RS21455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HH212_RS21465	COG0840	transmembrane signaling receptor activity
HH212_RS21505	COG5002	protein histidine kinase activity
HH212_RS21540	COG4251	negative regulation of phosphorylation
HH212_RS21540	COG5001	Diguanylate cyclase
HH212_RS21540	COG3706	GGDEF domain
HH212_RS21540	COG2203	Gaf domain
HH212_RS21550	COG0602	queuosine metabolic process
HH212_RS21555	COG0720	synthase
HH212_RS21570	COG1619	proteins homologs of microcin C7 resistance protein MccF
HH212_RS21575	COG0488	(ABC) transporter
HH212_RS21580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HH212_RS21590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HH212_RS21600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HH212_RS21605	COG0438	transferase activity, transferring glycosyl groups
HH212_RS21610	COG0438	transferase activity, transferring glycosyl groups
HH212_RS21625	COG1228	amidohydrolase
HH212_RS21645	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HH212_RS21660	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HH212_RS21665	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HH212_RS21670	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HH212_RS21675	COG2205	protein histidine kinase activity
HH212_RS21680	COG0745	RESPONSE REGULATOR receiver
HH212_RS21725	COG1450	Type ii and iii secretion system protein
HH212_RS21785	COG2271	Major facilitator Superfamily
HH212_RS21795	COG2721	sulfolactate sulfo-lyase activity
HH212_RS21800	COG1609	Transcriptional regulator
HH212_RS21855	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HH212_RS21865	COG0437	4 iron, 4 sulfur cluster binding
HH212_RS21870	COG2864	formate dehydrogenase
HH212_RS21880	COG1921	L-seryl-tRNASec selenium transferase activity
HH212_RS21885	COG3276	selenocysteine insertion sequence binding
HH212_RS21905	COG0243	molybdopterin cofactor binding
HH212_RS21910	COG0826	peptidase U32
HH212_RS21965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HH212_RS21975	COG0084	hydrolase, TatD family'
HH212_RS21980	COG1247	-acetyltransferase
HH212_RS21995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HH212_RS22000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HH212_RS22030	COG0432	Pfam Uncharacterised protein family UPF0047
HH212_RS22035	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS22065	COG1250	3-hydroxyacyl-CoA dehydrogenase
HH212_RS22065	COG1024	Enoyl-CoA hydratase
HH212_RS22075	COG1136	(ABC) transporter
HH212_RS22075	COG0577	efflux transmembrane transporter activity
HH212_RS22090	COG1136	(ABC) transporter
HH212_RS22090	COG0577	efflux transmembrane transporter activity
HH212_RS22095	COG0023	Translation Initiation Factor
HH212_RS22100	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HH212_RS22105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HH212_RS22110	COG2917	probably involved in intracellular septation
HH212_RS22120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HH212_RS22125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HH212_RS22140	COG0047	phosphoribosylformylglycinamidine synthase activity
HH212_RS22140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HH212_RS22155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HH212_RS22155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HH212_RS22170	COG4181	ATPase activity
HH212_RS22180	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HH212_RS22185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HH212_RS22200	COG0776	regulation of translation
HH212_RS22205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HH212_RS22210	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HH212_RS22215	COG0740	serine-type endopeptidase activity
HH212_RS22220	COG0544	peptidyl-prolyl cis-trans isomerase activity
HH212_RS22230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HH212_RS22245	COG1562	ergosterol biosynthetic process
HH212_RS22250	COG1233	COG1233 Phytoene dehydrogenase and related
HH212_RS22295	COG2267	carboxylic ester hydrolase activity
HH212_RS22300	COG1522	sequence-specific DNA binding
HH212_RS22305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HH212_RS22310	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HH212_RS22315	COG0303	'Molybdopterin
HH212_RS22325	COG1760	l-serine dehydratase
HH212_RS22330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH212_RS22335	COG0156	8-amino-7-oxononanoate synthase activity
HH212_RS22355	COG1505	serine-type exopeptidase activity
HH212_RS22370	COG0443	Heat shock 70 kDa protein
HH212_RS22390	COG0189	ligase activity
HH212_RS22390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HH212_RS22400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HH212_RS22400	COG0189	ligase activity
HH212_RS22410	COG0531	amino acid
HH212_RS22415	COG1408	metallophosphoesterase
HH212_RS22420	COG1280	lysine exporter protein (LysE YggA)
HH212_RS22435	COG1464	Belongs to the NlpA lipoprotein family
HH212_RS22440	COG2205	protein histidine kinase activity
HH212_RS22445	COG0628	permease
HH212_RS22460	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS22470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH212_RS22475	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HH212_RS22480	COG2080	2 iron, 2 sulfur cluster binding
HH212_RS22505	COG2271	Major facilitator Superfamily
HH212_RS22510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HH212_RS22515	COG1802	Transcriptional regulator
HH212_RS22540	COG1404	Belongs to the peptidase S8 family
HH212_RS22555	COG2194	sulfuric ester hydrolase activity
HH212_RS22575	COG2826	transposase and inactivated derivatives, IS30 family
HH212_RS22600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HH212_RS22650	COG0668	transmembrane transport
HH212_RS22675	COG1388	LysM domain
HH212_RS22675	COG1705	Flagellar rod assembly protein muramidase FlgJ
HH212_RS22700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HH212_RS22700	COG2205	protein histidine kinase activity
HH212_RS22730	COG3706	GGDEF domain
HH212_RS22740	COG4771	TonB-dependent receptor
HH212_RS22750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HH212_RS22755	COG0385	Bile acid
HH212_RS22805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HH212_RS22830	COG2200	EAL domain
HH212_RS22840	COG5001	Diguanylate cyclase
HH212_RS22955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HH212_RS22970	COG5000	phosphorelay sensor kinase activity
HH212_RS23015	COG0328	RNA-DNA hybrid ribonuclease activity
HH212_RS23020	COG2226	methyltransferase
HH212_RS23025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HH212_RS23030	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HH212_RS23035	COG0583	DNA-binding transcription factor activity
HH212_RS23040	COG1278	Cold shock
HH212_RS23050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HH212_RS23055	COG1960	acyl-CoA dehydrogenase activity
HH212_RS23070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HH212_RS23095	COG1295	ribonuclease BN
HH212_RS23110	COG0277	FAD linked oxidase domain protein
HH212_RS23125	COG1132	(ABC) transporter
HH212_RS23130	COG0840	transmembrane signaling receptor activity
HH212_RS23150	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HH212_RS23170	COG1982	Orn Lys Arg decarboxylase major
HH212_RS23175	COG0717	Belongs to the dCTP deaminase family
HH212_RS23190	COG0745	RESPONSE REGULATOR receiver
HH212_RS23195	COG2205	protein histidine kinase activity
HH212_RS23230	COG3501	Rhs element vgr protein
HH212_RS23235	COG0084	hydrolase, TatD family'
HH212_RS23240	COG1136	(ABC) transporter
HH212_RS23245	COG4591	ABC-type transport system involved in lipoprotein release permease component
HH212_RS23255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HH212_RS23295	COG0612	Peptidase, M16
HH212_RS23305	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HH212_RS23320	COG0535	radical SAM domain protein
HH212_RS23325	COG0840	transmembrane signaling receptor activity
HH212_RS23355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HH212_RS23360	COG1611	Belongs to the LOG family
HH212_RS23365	COG3104	oligopeptide transport
HH212_RS23420	COG3209	COG3209 Rhs family protein
HH212_RS23425	COG3501	Rhs element vgr protein
HH212_RS23440	COG0657	acetylesterase activity
HH212_RS23440	COG2755	lipolytic protein G-D-S-L family
HH212_RS23450	COG1297	OPT oligopeptide transporter protein
HH212_RS23470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HH212_RS23475	COG0560	Phosphoserine phosphatase
HH212_RS23515	COG0783	Belongs to the Dps family
HH212_RS23520	COG3507	Belongs to the glycosyl hydrolase 43 family
HH212_RS23530	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HH212_RS23535	COG1929	Belongs to the glycerate kinase type-1 family
HH212_RS23540	COG2271	Major facilitator Superfamily
HH212_RS23545	COG3835	regulator
HH212_RS23570	COG3118	belongs to the thioredoxin family
HH212_RS23580	COG0626	cystathionine gamma-synthase activity
HH212_RS23585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HH212_RS23595	COG3243	poly(R)-hydroxyalkanoic acid synthase
HH212_RS23610	COG0564	pseudouridine synthase activity
HH212_RS23620	COG1301	dicarboxylic acid transport
HH212_RS23630	COG0583	DNA-binding transcription factor activity
HH212_RS23635	COG3022	response to hydroperoxide
HH212_RS23645	COG0436	Aminotransferase
HH212_RS23655	COG3267	Type II secretory pathway component ExeA
HH212_RS23655	COG3409	Peptidoglycan-binding domain 1 protein
HH212_RS23710	COG4969	Belongs to the N-Me-Phe pilin family
HH212_RS23715	COG1459	type II secretion system
HH212_RS23720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HH212_RS23725	COG2205	protein histidine kinase activity
HH212_RS23725	COG5002	protein histidine kinase activity
HH212_RS23725	COG0784	Response regulator, receiver
HH212_RS23730	COG2203	Gaf domain
HH212_RS23730	COG5001	Diguanylate cyclase
HH212_RS23730	COG4251	negative regulation of phosphorylation
HH212_RS23730	COG3706	GGDEF domain
HH212_RS23740	COG0793	Belongs to the peptidase S41A family
HH212_RS23750	COG1435	thymidine kinase activity
HH212_RS23760	COG2366	antibiotic biosynthetic process
HH212_RS23790	COG3706	GGDEF domain
HH212_RS23800	COG0443	Heat shock 70 kDa protein
HH212_RS23805	COG2135	peptidase activity
HH212_RS23830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HH212_RS23830	COG0515	serine threonine protein kinase
HH212_RS23865	COG0840	transmembrane signaling receptor activity
HH212_RS23870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HH212_RS23870	COG0515	serine threonine protein kinase
HH212_RS23920	COG1418	mRNA catabolic process
HH212_RS23930	COG0688	phosphatidylethanolamine metabolic process
HH212_RS23940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HH212_RS23970	COG0671	phosphoesterase, PA-phosphatase related
HH212_RS23975	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HH212_RS23980	COG0463	Glycosyl transferase, family 2
HH212_RS24015	COG3706	GGDEF domain
HH212_RS24020	COG5001	Diguanylate cyclase
HH212_RS24020	COG3300	MHYT domain
HH212_RS24035	COG1393	Belongs to the ArsC family
HH212_RS24045	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HH212_RS24050	COG0830	nickel cation binding
HH212_RS24055	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HH212_RS24060	COG0804	urea catabolic process
HH212_RS24075	COG0831	urea catabolic process
HH212_RS24080	COG0829	nickel cation binding
HH212_RS24095	COG3706	GGDEF domain
HH212_RS24100	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS24105	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HH212_RS24130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HH212_RS24165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HH212_RS24165	COG2205	protein histidine kinase activity
HH212_RS24180	COG0784	Response regulator, receiver
HH212_RS24180	COG2205	protein histidine kinase activity
HH212_RS24200	COG5002	protein histidine kinase activity
HH212_RS24210	COG4585	Histidine kinase
HH212_RS24215	COG1252	NADH dehydrogenase
HH212_RS24230	COG0513	Belongs to the DEAD box helicase family
HH212_RS24240	COG3507	Belongs to the glycosyl hydrolase 43 family
HH212_RS24260	COG2212	antiporter activity
HH212_RS24265	COG1863	multisubunit Na H antiporter MnhE subunit
HH212_RS24270	COG0651	ATP synthesis coupled electron transport
HH212_RS24275	COG1006	Multisubunit Na H antiporter MnhC subunit
HH212_RS24280	COG2111	Na H antiporter
HH212_RS24280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HH212_RS24295	COG0840	transmembrane signaling receptor activity
HH212_RS24325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HH212_RS24325	COG1042	CoA-binding domain protein
HH212_RS24325	COG0045	succinate-CoA ligase (ADP-forming) activity
HH212_RS24365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HH212_RS24405	COG2217	Heavy metal translocating P-type atpase
HH212_RS24420	COG0625	glutathione transferase activity
HH212_RS24425	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS24430	COG1741	Belongs to the pirin family
HH212_RS24435	COG1741	Belongs to the pirin family
HH212_RS24440	COG0583	DNA-binding transcription factor activity
HH212_RS24450	COG2062	phosphohistidine phosphatase, SixA
HH212_RS24455	COG1794	racemase activity, acting on amino acids and derivatives
HH212_RS24465	COG0673	inositol 2-dehydrogenase activity
HH212_RS24480	COG0596	Alpha beta hydrolase
HH212_RS24500	COG0248	Ppx GppA phosphatase
HH212_RS24525	COG2885	chlorophyll binding
HH212_RS24530	COG1609	Transcriptional regulator
HH212_RS24555	COG4771	TonB-dependent receptor
HH212_RS24595	COG3384	dioxygenase
HH212_RS24605	COG0583	DNA-binding transcription factor activity
HH212_RS24615	COG2159	amidohydrolase
HH212_RS24625	COG3023	N-Acetylmuramoyl-L-alanine amidase
HH212_RS24635	COG1234	tRNA 3'-trailer cleavage
HH212_RS24640	COG3275	phosphorelay sensor kinase activity
HH212_RS24665	COG0583	DNA-binding transcription factor activity
HH212_RS24680	COG0572	uridine kinase
HH212_RS24690	COG3158	transport of potassium into the cell
HH212_RS24705	COG1289	transmembrane transporter activity
HH212_RS24760	COG2885	chlorophyll binding
HH212_RS24795	COG1450	Type ii and iii secretion system protein
HH212_RS24850	COG0582	viral genome integration into host DNA
HH212_RS24865	COG0037	tRNA processing
HH212_RS24870	COG0825	malonyl-CoA metabolic process
HH212_RS24880	COG0215	cysteine-tRNA ligase activity
HH212_RS24885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HH212_RS24895	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HH212_RS24905	COG1131	(ABC) transporter
HH212_RS24915	COG3132	Protein of unknown function, DUF480
HH212_RS24920	COG1045	serine acetyltransferase
HH212_RS24925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HH212_RS24960	COG0789	Transcriptional regulator
HH212_RS25060	COG3279	Response regulator of the LytR AlgR family
HH212_RS25065	COG3275	phosphorelay sensor kinase activity
HH212_RS25145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HH212_RS25150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HH212_RS25170	COG1596	polysaccharide export
HH212_RS25180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HH212_RS25195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HH212_RS25200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HH212_RS25205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HH212_RS25210	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HH212_RS25225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HH212_RS25230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HH212_RS25235	COG0505	Belongs to the CarA family
HH212_RS25240	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HH212_RS25245	COG1752	Esterase of the alpha-beta hydrolase superfamily
HH212_RS25250	COG5002	protein histidine kinase activity
HH212_RS25260	COG0704	Plays a role in the regulation of phosphate uptake
HH212_RS25265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HH212_RS25275	COG0573	inorganic phosphate transmembrane transporter activity
HH212_RS25280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HH212_RS25295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HH212_RS25300	COG0477	Major facilitator Superfamily
HH212_RS25310	COG1573	uracil-dna glycosylase
HH212_RS25320	COG1214	PFAM Peptidase M22, glycoprotease
HH212_RS25350	COG0741	lytic transglycosylase activity
HH212_RS25350	COG1388	LysM domain
HH212_RS25355	COG0513	Belongs to the DEAD box helicase family
HH212_RS25360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HH212_RS25370	COG0709	Synthesizes selenophosphate from selenide and ATP
HH212_RS25390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HH212_RS25400	COG1295	ribonuclease BN
HH212_RS25405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HH212_RS25410	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HH212_RS25430	COG5002	protein histidine kinase activity
HH212_RS25430	COG5001	Diguanylate cyclase
HH212_RS25430	COG3447	MASE1 domain protein
HH212_RS25435	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HH212_RS25480	COG1376	ErfK ybiS ycfS ynhG family protein
HH212_RS25505	COG2321	neutral zinc metallopeptidase
HH212_RS25520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HH212_RS25535	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HH212_RS25570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HH212_RS25580	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HH212_RS25595	COG0492	ferredoxin-NADP+ reductase activity
HH212_RS25600	COG2840	Smr protein MutS2
HH212_RS25610	COG2860	membrane
HH212_RS25620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HH212_RS25620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HH212_RS25630	COG0456	acetyltransferase
HH212_RS25640	COG4771	TonB-dependent receptor
HH212_RS25655	COG0411	ABC transporter
HH212_RS25685	COG1404	Belongs to the peptidase S8 family
HH212_RS25685	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HH212_RS25690	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HH212_RS25700	COG2959	enzyme of heme biosynthesis
HH212_RS25710	COG0181	hydroxymethylbilane synthase activity
HH212_RS25715	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HH212_RS25765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH212_RS25765	COG2010	Cytochrome c
HH212_RS25800	COG0788	formyltetrahydrofolate deformylase activity
HH212_RS25810	COG1451	nucleotide metabolic process
HH212_RS25830	COG3706	GGDEF domain
HH212_RS25840	COG1309	transcriptional regulator
HH212_RS25850	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HH212_RS25860	COG0513	Belongs to the DEAD box helicase family
HH212_RS25875	COG3622	Belongs to the hyi family
HH212_RS25890	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS25900	COG3228	Belongs to the MtfA family
HH212_RS25905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HH212_RS25905	COG0678	peroxiredoxin activity
HH212_RS25920	COG1295	ribonuclease BN
HH212_RS25925	COG0628	permease
HH212_RS25970	COG2982	Protein involved in outer membrane biogenesis
HH212_RS26005	COG4206	TonB-dependent receptor
HH212_RS26020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HH212_RS26025	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HH212_RS26030	COG1597	lipid kinase activity
HH212_RS26035	COG0671	phosphoesterase, PA-phosphatase related
HH212_RS26045	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HH212_RS26050	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS26055	COG1028	Short-chain dehydrogenase reductase Sdr
HH212_RS26070	COG0366	Alpha amylase catalytic
HH212_RS26235	COG0740	serine-type endopeptidase activity
HH212_RS26250	COG4626	Terminase
HH212_RS26250	COG1802	Transcriptional regulator
HH212_RS26380	COG3328	transposase activity
HH212_RS26405	COG0612	Peptidase, M16
HH212_RS26410	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HH212_RS26425	COG2826	transposase and inactivated derivatives, IS30 family
HH212_RS26440	COG4644	lycopene metabolic process
HH212_RS26450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HH212_RS26460	COG2826	transposase and inactivated derivatives, IS30 family
HH212_RS26490	COG3328	transposase activity
HH212_RS26515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HH212_RS26520	COG0601	transmembrane transport
HH212_RS26525	COG0747	negative chemotaxis
HH212_RS26550	COG1566	PFAM secretion protein HlyD family protein
HH212_RS26555	COG0477	Major facilitator Superfamily
HH212_RS26600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HH212_RS26610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HH212_RS26680	COG0789	Transcriptional regulator
HH212_RS26730	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HH212_RS26780	COG4974	Belongs to the 'phage' integrase family
HH212_RS26800	COG0039	L-malate dehydrogenase activity
HH212_RS26820	COG2855	membrane
HH212_RS26825	COG0583	DNA-binding transcription factor activity
HH212_RS26830	COG0390	transport system, permease component
HH212_RS26835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HH212_RS26850	COG0038	chloride channel
HH212_RS26860	COG0148	phosphopyruvate hydratase activity
HH212_RS26865	COG0588	phosphoglycerate mutase activity
HH212_RS26870	COG3391	amine dehydrogenase activity
HH212_RS26895	COG1192	Involved in chromosome partitioning
HH212_RS26910	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HH212_RS26940	COG4973	Belongs to the 'phage' integrase family. XerC subfamily