locus-tag	class	description
FDZ78_RS00025	COG3023	N-Acetylmuramoyl-L-alanine amidase
FDZ78_RS00215	COG4974	Belongs to the 'phage' integrase family
FDZ78_RS00220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FDZ78_RS00230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FDZ78_RS00295	COG5433	transposase activity
FDZ78_RS00475	COG4974	Belongs to the 'phage' integrase family
FDZ78_RS00510	COG0732	type I restriction modification DNA specificity domain
FDZ78_RS00515	COG0732	type I restriction modification DNA specificity domain
FDZ78_RS00650	COG1401	restriction endodeoxyribonuclease activity
FDZ78_RS00725	COG4974	Belongs to the 'phage' integrase family
FDZ78_RS00735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FDZ78_RS00740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FDZ78_RS00760	COG1120	ATPase activity
FDZ78_RS00765	COG1217	gtp-binding protein TYPA
FDZ78_RS00775	COG0280	phosphate acetyltransferase
FDZ78_RS00780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FDZ78_RS00785	COG0673	inositol 2-dehydrogenase activity
FDZ78_RS00795	COG1280	lysine exporter protein (LysE YggA)
FDZ78_RS00815	COG1472	Belongs to the glycosyl hydrolase 3 family
FDZ78_RS00835	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FDZ78_RS00840	COG4206	TonB-dependent receptor
FDZ78_RS00840	COG1629	transport
FDZ78_RS00855	COG1082	Xylose isomerase domain protein TIM barrel
FDZ78_RS00870	COG3250	beta-galactosidase activity
FDZ78_RS00925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FDZ78_RS00935	COG0799	negative regulation of ribosome biogenesis
FDZ78_RS00940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FDZ78_RS00950	COG1013	pyruvate-flavodoxin oxidoreductase activity
FDZ78_RS00950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FDZ78_RS00950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FDZ78_RS00950	COG0674	pyruvate-flavodoxin oxidoreductase activity
FDZ78_RS00955	COG0679	Auxin Efflux Carrier
FDZ78_RS00960	COG0028	Belongs to the TPP enzyme family
FDZ78_RS00970	COG2059	Chromate
FDZ78_RS00980	COG0285	dihydrofolate synthase activity
FDZ78_RS00985	COG2954	triphosphatase activity
FDZ78_RS01000	COG0318	PFAM AMP-dependent synthetase and ligase
FDZ78_RS01005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FDZ78_RS01010	COG2195	Cleaves the N-terminal amino acid of tripeptides
FDZ78_RS01020	COG3507	Belongs to the glycosyl hydrolase 43 family
FDZ78_RS01070	COG2502	aspartate--ammonia ligase
FDZ78_RS01080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FDZ78_RS01090	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FDZ78_RS01095	COG1028	Short-chain dehydrogenase reductase Sdr
FDZ78_RS01100	COG3775	system Galactitol-specific IIC component
FDZ78_RS01105	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FDZ78_RS01165	COG1328	CTP reductase activity
FDZ78_RS01170	COG0602	queuosine metabolic process
FDZ78_RS01175	COG1127	ABC transporter
FDZ78_RS01180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FDZ78_RS01185	COG0124	histidyl-tRNA synthetase
FDZ78_RS01195	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FDZ78_RS01205	COG0534	Mate efflux family protein
FDZ78_RS01215	COG0019	diaminopimelate decarboxylase activity
FDZ78_RS01220	COG0527	aspartate kinase activity
FDZ78_RS01220	COG0460	homoserine dehydrogenase
FDZ78_RS01235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FDZ78_RS01265	COG0628	permease
FDZ78_RS01280	COG0772	Belongs to the SEDS family
FDZ78_RS01300	COG1077	Cell shape determining protein MreB Mrl
FDZ78_RS01305	COG0138	bifunctional purine biosynthesis protein purh
FDZ78_RS01310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FDZ78_RS01325	COG1649	PFAM Uncharacterised BCR, COG1649
FDZ78_RS01345	COG2843	Capsule synthesis protein
FDZ78_RS01350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FDZ78_RS01355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FDZ78_RS01360	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FDZ78_RS01365	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FDZ78_RS01370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FDZ78_RS01380	COG0492	ferredoxin-NADP+ reductase activity
FDZ78_RS01390	COG1674	ftsk spoiiie
FDZ78_RS01395	COG3401	FG-GAP repeat protein
FDZ78_RS01400	COG0716	FMN binding
FDZ78_RS01405	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FDZ78_RS01415	COG0511	ligase activity, forming carbon-carbon bonds
FDZ78_RS01415	COG5016	pyruvate
FDZ78_RS01420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FDZ78_RS01425	COG0357	Ribosomal RNA small subunit methyltransferase G
FDZ78_RS01435	COG0488	(ABC) transporter
FDZ78_RS01535	COG0681	Belongs to the peptidase S26 family
FDZ78_RS01565	COG3385	transposase activity
FDZ78_RS01730	COG3023	N-Acetylmuramoyl-L-alanine amidase
FDZ78_RS01825	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FDZ78_RS01830	COG0534	Mate efflux family protein
FDZ78_RS01835	COG2814	Major facilitator Superfamily
FDZ78_RS01845	COG0039	L-malate dehydrogenase activity
FDZ78_RS01850	COG1160	GTP binding
FDZ78_RS01855	COG1070	Carbohydrate kinase
FDZ78_RS01860	COG4806	L-rhamnose isomerase
FDZ78_RS01870	COG0235	Class ii aldolase
FDZ78_RS01880	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FDZ78_RS01895	COG1733	regulation of RNA biosynthetic process
FDZ78_RS01900	COG1242	4 iron, 4 sulfur cluster binding
FDZ78_RS01915	COG0297	glycogen (starch) synthase activity
FDZ78_RS01920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FDZ78_RS01930	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FDZ78_RS01935	COG0352	thiamine-phosphate diphosphorylase activity
FDZ78_RS01935	COG0351	phosphomethylpyrimidine kinase
FDZ78_RS01945	COG0352	thiamine-phosphate diphosphorylase activity
FDZ78_RS01955	COG2022	thiamine diphosphate biosynthetic process
FDZ78_RS01960	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FDZ78_RS01975	COG2885	chlorophyll binding
FDZ78_RS01990	COG0017	Asparaginyl-tRNA synthetase
FDZ78_RS01995	COG1187	pseudouridine synthase activity
FDZ78_RS02000	COG0788	formyltetrahydrofolate deformylase activity
FDZ78_RS02005	COG1523	belongs to the glycosyl hydrolase 13 family
FDZ78_RS02015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FDZ78_RS02035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FDZ78_RS02035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FDZ78_RS02040	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FDZ78_RS02045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FDZ78_RS02055	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FDZ78_RS02060	COG2089	acid synthase
FDZ78_RS02070	COG1088	dTDP-glucose 4,6-dehydratase activity
FDZ78_RS02110	COG0012	GTP binding
FDZ78_RS02135	COG0860	N-Acetylmuramoyl-L-alanine amidase
FDZ78_RS02145	COG0427	acetyl-CoA hydrolase
FDZ78_RS02155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FDZ78_RS02160	COG1678	Uncharacterized ACR, COG1678
FDZ78_RS02165	COG0228	four-way junction DNA binding
FDZ78_RS02170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FDZ78_RS02185	COG1668	transmembrane transport
FDZ78_RS02190	COG4152	abc transporter atp-binding protein
FDZ78_RS02195	COG1595	DNA-templated transcription, initiation
FDZ78_RS02205	COG0540	Belongs to the ATCase OTCase family
FDZ78_RS02210	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FDZ78_RS02215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FDZ78_RS02220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FDZ78_RS02255	COG0191	fructose-bisphosphate aldolase activity
FDZ78_RS02260	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FDZ78_RS02270	COG1115	amino acid carrier protein
FDZ78_RS02280	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FDZ78_RS02285	COG1472	Belongs to the glycosyl hydrolase 3 family
FDZ78_RS02290	COG0708	Exodeoxyribonuclease III
FDZ78_RS02295	COG1136	(ABC) transporter
FDZ78_RS02305	COG1136	(ABC) transporter
FDZ78_RS02305	COG0577	efflux transmembrane transporter activity
FDZ78_RS02325	COG0733	neurotransmitter:sodium symporter activity
FDZ78_RS02385	COG0288	reversible hydration of carbon dioxide
FDZ78_RS02400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FDZ78_RS02405	COG0006	proline dipeptidase activity
FDZ78_RS02405	COG0006	proline dipeptidase activity
FDZ78_RS02410	COG1234	tRNA 3'-trailer cleavage
FDZ78_RS02415	COG0738	Major facilitator superfamily
FDZ78_RS02425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FDZ78_RS02430	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FDZ78_RS02435	COG0166	Belongs to the GPI family
FDZ78_RS02445	COG1854	S-ribosylhomocysteine lyase activity
FDZ78_RS02455	COG0805	protein transport
FDZ78_RS02460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FDZ78_RS02465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FDZ78_RS02475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FDZ78_RS02495	COG4771	TonB-dependent receptor
FDZ78_RS02505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FDZ78_RS02520	COG0546	phosphoglycolate phosphatase activity
FDZ78_RS02525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FDZ78_RS02545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FDZ78_RS02555	COG0564	pseudouridine synthase activity
FDZ78_RS02560	COG0339	signal peptide processing
FDZ78_RS02570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FDZ78_RS02575	COG0750	zinc metalloprotease
FDZ78_RS02580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FDZ78_RS02625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FDZ78_RS02635	COG4464	protein tyrosine phosphatase activity
FDZ78_RS02655	COG1215	transferase activity, transferring glycosyl groups
FDZ78_RS02675	COG0667	Aldo Keto reductase
FDZ78_RS02685	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FDZ78_RS02710	COG0203	ribosomal protein L17
FDZ78_RS02715	COG0202	RNA polymerase activity
FDZ78_RS02720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FDZ78_RS02725	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FDZ78_RS02730	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FDZ78_RS02735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FDZ78_RS02740	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FDZ78_RS02750	COG0201	protein transport
FDZ78_RS02755	COG0200	Binds to the 23S rRNA
FDZ78_RS02760	COG1841	ribosomal large subunit assembly
FDZ78_RS02765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FDZ78_RS02770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FDZ78_RS02775	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FDZ78_RS02780	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FDZ78_RS02785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FDZ78_RS02790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FDZ78_RS02795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FDZ78_RS02800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FDZ78_RS02805	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FDZ78_RS02810	COG0255	Belongs to the universal ribosomal protein uL29 family
FDZ78_RS02815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FDZ78_RS02820	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FDZ78_RS02825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FDZ78_RS02830	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FDZ78_RS02835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FDZ78_RS02840	COG0089	rRNA binding
FDZ78_RS02845	COG0088	Forms part of the polypeptide exit tunnel
FDZ78_RS02850	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FDZ78_RS02855	COG0051	transcription antitermination factor activity, RNA binding
FDZ78_RS02860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FDZ78_RS02865	COG0049	tRNA binding
FDZ78_RS02870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FDZ78_RS02875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FDZ78_RS02875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FDZ78_RS02880	COG0252	asparaginase activity
FDZ78_RS02890	COG2003	Belongs to the UPF0758 family
FDZ78_RS02895	COG1216	Glycosyl transferase, family 2
FDZ78_RS02895	COG0463	Glycosyl transferase, family 2
FDZ78_RS02920	COG2321	neutral zinc metallopeptidase
FDZ78_RS02925	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FDZ78_RS02935	COG0513	Belongs to the DEAD box helicase family
FDZ78_RS02945	COG4584	PFAM Integrase catalytic
FDZ78_RS02950	COG1484	DNA-dependent DNA replication
FDZ78_RS02980	COG1373	ATPase (AAA superfamily
FDZ78_RS03005	COG1484	DNA-dependent DNA replication
FDZ78_RS03030	COG4974	Belongs to the 'phage' integrase family
FDZ78_RS03040	COG4804	nuclease activity
FDZ78_RS03220	COG0778	Nitroreductase
FDZ78_RS03225	COG3385	transposase activity
FDZ78_RS03245	COG5433	transposase activity
FDZ78_RS03280	COG5002	protein histidine kinase activity
FDZ78_RS03285	COG0745	RESPONSE REGULATOR receiver
FDZ78_RS03305	COG0534	Mate efflux family protein
FDZ78_RS03310	COG0110	maltose O-acetyltransferase activity
FDZ78_RS03340	COG4771	TonB-dependent receptor
FDZ78_RS03370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FDZ78_RS03380	COG1621	beta-fructofuranosidase activity
FDZ78_RS03385	COG0745	RESPONSE REGULATOR receiver
FDZ78_RS03385	COG3292	Two component regulator propeller
FDZ78_RS03385	COG2205	protein histidine kinase activity
FDZ78_RS03390	COG1629	transport
FDZ78_RS03510	COG3392	D12 class N6 adenine-specific DNA methyltransferase
FDZ78_RS03630	COG1629	transport
FDZ78_RS03665	COG4974	Belongs to the 'phage' integrase family
FDZ78_RS03680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FDZ78_RS03680	COG1754	DNA topoisomerase type I activity
FDZ78_RS03720	COG0745	RESPONSE REGULATOR receiver
FDZ78_RS03835	COG0582	viral genome integration into host DNA
FDZ78_RS03840	COG0582	viral genome integration into host DNA
FDZ78_RS03845	COG0582	viral genome integration into host DNA
FDZ78_RS03870	COG1373	ATPase (AAA superfamily
FDZ78_RS03935	COG4974	Belongs to the 'phage' integrase family
FDZ78_RS03970	COG3290	protein histidine kinase activity
FDZ78_RS04125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FDZ78_RS04135	COG5433	transposase activity
FDZ78_RS04140	COG0544	peptidyl-prolyl cis-trans isomerase activity
FDZ78_RS04145	COG0534	Mate efflux family protein
FDZ78_RS04155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FDZ78_RS04160	COG0823	Involved in the tonB-independent uptake of proteins
FDZ78_RS04160	COG1506	peptidase
FDZ78_RS04170	COG2860	membrane
FDZ78_RS04175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FDZ78_RS04180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FDZ78_RS04185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FDZ78_RS04195	COG4206	TonB-dependent receptor
FDZ78_RS04195	COG1629	transport
FDZ78_RS04230	COG4232	protein-disulfide reductase activity
FDZ78_RS04260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FDZ78_RS04270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FDZ78_RS04285	COG0702	epimerase
FDZ78_RS04290	COG1629	transport
FDZ78_RS04295	COG2205	protein histidine kinase activity
FDZ78_RS04295	COG3292	Two component regulator propeller
FDZ78_RS04295	COG0745	RESPONSE REGULATOR receiver
FDZ78_RS04300	COG1501	Belongs to the glycosyl hydrolase 31 family
FDZ78_RS04305	COG3250	beta-galactosidase activity
FDZ78_RS04310	COG1472	Belongs to the glycosyl hydrolase 3 family
FDZ78_RS04315	COG0668	transmembrane transport
FDZ78_RS04330	COG0671	phosphoesterase, PA-phosphatase related
FDZ78_RS04350	COG0205	6-phosphofructokinase activity
FDZ78_RS04355	COG1136	(ABC) transporter
FDZ78_RS04380	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FDZ78_RS04385	COG0741	lytic transglycosylase activity
FDZ78_RS04395	COG1475	DNA binding
FDZ78_RS04400	COG1192	Involved in chromosome partitioning
FDZ78_RS04410	COG2205	protein histidine kinase activity
FDZ78_RS04415	COG4535	Mg2 and Co2 transporter CorC
FDZ78_RS04430	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FDZ78_RS04440	COG1271	oxidase subunit
FDZ78_RS04450	COG1215	transferase activity, transferring glycosyl groups
FDZ78_RS04480	COG1362	aminopeptidase activity
FDZ78_RS04485	COG1501	Belongs to the glycosyl hydrolase 31 family
FDZ78_RS04495	COG4974	Belongs to the 'phage' integrase family
FDZ78_RS04545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FDZ78_RS04550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FDZ78_RS04555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FDZ78_RS04560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FDZ78_RS04575	COG0438	transferase activity, transferring glycosyl groups
FDZ78_RS04610	COG3385	transposase activity
FDZ78_RS04620	COG3118	belongs to the thioredoxin family
FDZ78_RS04625	COG1546	Belongs to the CinA family
FDZ78_RS04625	COG1058	Belongs to the CinA family
FDZ78_RS04630	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FDZ78_RS04640	COG2885	chlorophyll binding
FDZ78_RS04650	COG0719	Fe-S assembly protein
FDZ78_RS04655	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FDZ78_RS04685	COG0545	Peptidyl-prolyl cis-trans isomerase
FDZ78_RS04690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FDZ78_RS04695	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FDZ78_RS04700	COG0586	Pfam SNARE associated Golgi protein
FDZ78_RS04710	COG0426	domain, Protein
FDZ78_RS04715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FDZ78_RS04720	COG1047	Peptidyl-prolyl cis-trans
FDZ78_RS04730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FDZ78_RS04735	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FDZ78_RS04750	COG0531	amino acid
FDZ78_RS04755	COG0688	phosphatidylethanolamine metabolic process
FDZ78_RS04760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FDZ78_RS04765	COG1115	amino acid carrier protein
FDZ78_RS04775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FDZ78_RS04785	COG0101	tRNA pseudouridine synthase activity
FDZ78_RS04790	COG1166	arginine decarboxylase activity
FDZ78_RS04805	COG1045	serine acetyltransferase
FDZ78_RS04810	COG0116	Belongs to the methyltransferase superfamily
FDZ78_RS04810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FDZ78_RS04825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FDZ78_RS04865	COG3385	transposase activity
FDZ78_RS04870	COG4657	Part of a membrane complex involved in electron transport
FDZ78_RS04875	COG4660	Part of a membrane complex involved in electron transport
FDZ78_RS04880	COG4659	FMN binding
FDZ78_RS04885	COG4658	electron transport chain
FDZ78_RS04895	COG0702	epimerase
FDZ78_RS04900	COG4771	TonB-dependent receptor
FDZ78_RS04905	COG5433	transposase activity
FDZ78_RS04925	COG0246	Mannitol dehydrogenase
FDZ78_RS04930	COG2721	sulfolactate sulfo-lyase activity
FDZ78_RS04935	COG1904	glucuronate isomerase
FDZ78_RS04940	COG2271	Major facilitator Superfamily
FDZ78_RS04945	COG2221	Nitrite and sulphite reductase 4Fe-4S
FDZ78_RS04970	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FDZ78_RS04985	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
FDZ78_RS04995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FDZ78_RS05000	COG2855	membrane
FDZ78_RS05005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FDZ78_RS05055	COG3594	Acyltransferase
FDZ78_RS05080	COG1216	Glycosyl transferase, family 2
FDZ78_RS05085	COG3594	Acyltransferase
FDZ78_RS05090	COG1216	Glycosyl transferase, family 2
FDZ78_RS05105	COG1442	glycosyl transferase family 8
FDZ78_RS05105	COG1216	Glycosyl transferase, family 2
FDZ78_RS05110	COG1216	Glycosyl transferase, family 2
FDZ78_RS05115	COG1216	Glycosyl transferase, family 2
FDZ78_RS05115	COG1442	glycosyl transferase family 8
FDZ78_RS05130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FDZ78_RS05135	COG0656	L-ascorbic acid biosynthetic process
FDZ78_RS05170	COG0612	Peptidase, M16
FDZ78_RS05175	COG0525	valine-tRNA ligase activity
FDZ78_RS05180	COG0756	dUTP diphosphatase activity
FDZ78_RS05200	COG0513	Belongs to the DEAD box helicase family
FDZ78_RS05220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FDZ78_RS05235	COG0653	protein targeting
FDZ78_RS05305	COG0589	response to stress
FDZ78_RS05305	COG0475	glutathione-regulated potassium exporter activity
FDZ78_RS05315	COG0826	peptidase U32
FDZ78_RS05320	COG0436	Aminotransferase
FDZ78_RS05325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FDZ78_RS05345	COG0802	atpase or kinase
FDZ78_RS05355	COG3118	belongs to the thioredoxin family
FDZ78_RS05360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FDZ78_RS05375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FDZ78_RS05380	COG3409	Peptidoglycan-binding domain 1 protein
FDZ78_RS05380	COG0793	Belongs to the peptidase S41A family
FDZ78_RS05385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FDZ78_RS05395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FDZ78_RS05400	COG0085	RNA polymerase activity
FDZ78_RS05405	COG0222	ribosome binding
FDZ78_RS05410	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FDZ78_RS05415	COG0081	regulation of translation
FDZ78_RS05420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FDZ78_RS05440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FDZ78_RS05465	COG3458	cephalosporin-C deacetylase activity
FDZ78_RS05495	COG0137	argininosuccinate synthase activity
FDZ78_RS05500	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FDZ78_RS05505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FDZ78_RS05510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FDZ78_RS05515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FDZ78_RS05520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FDZ78_RS05525	COG0165	Argininosuccinate lyase
FDZ78_RS05545	COG5433	transposase activity
FDZ78_RS05565	COG1490	D-aminoacyl-tRNA deacylase activity
FDZ78_RS05575	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FDZ78_RS05590	COG1480	7TM receptor with intracellular HD hydrolase
FDZ78_RS05595	COG1472	Belongs to the glycosyl hydrolase 3 family
FDZ78_RS05600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FDZ78_RS05605	COG0686	Belongs to the AlaDH PNT family
FDZ78_RS05610	COG0328	RNA-DNA hybrid ribonuclease activity
FDZ78_RS05610	COG3341	Caulimovirus viroplasmin
FDZ78_RS05655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FDZ78_RS05685	COG1597	lipid kinase activity
FDZ78_RS05695	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FDZ78_RS05715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FDZ78_RS05720	COG0438	transferase activity, transferring glycosyl groups
FDZ78_RS05735	COG1505	serine-type exopeptidase activity
FDZ78_RS05770	COG4974	Belongs to the 'phage' integrase family
FDZ78_RS05790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FDZ78_RS05795	COG0537	adenosine 5'-monophosphoramidase activity
FDZ78_RS05815	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FDZ78_RS05830	COG4536	flavin adenine dinucleotide binding
FDZ78_RS05840	COG1570	exodeoxyribonuclease VII activity
FDZ78_RS05855	COG0482	sulfurtransferase activity
FDZ78_RS05865	COG2211	Major facilitator Superfamily
FDZ78_RS05870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FDZ78_RS05875	COG0457	Tetratricopeptide repeat
FDZ78_RS05880	COG4771	TonB-dependent receptor
FDZ78_RS05910	COG1418	mRNA catabolic process
FDZ78_RS05915	COG1774	PSP1 C-terminal conserved region
FDZ78_RS05940	COG1013	pyruvate-flavodoxin oxidoreductase activity
FDZ78_RS05945	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FDZ78_RS05945	COG0674	pyruvate-flavodoxin oxidoreductase activity
FDZ78_RS05955	COG0463	Glycosyl transferase, family 2
FDZ78_RS05970	COG0105	UTP biosynthetic process
FDZ78_RS05975	COG0739	heme binding
FDZ78_RS05985	COG1253	flavin adenine dinucleotide binding
FDZ78_RS05990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FDZ78_RS05995	COG1695	Transcriptional regulator
FDZ78_RS06005	COG4974	Belongs to the 'phage' integrase family
FDZ78_RS06025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FDZ78_RS06030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FDZ78_RS06035	COG0195	Participates in both transcription termination and antitermination
FDZ78_RS06040	COG0779	Required for maturation of 30S ribosomal subunits
FDZ78_RS06075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FDZ78_RS06095	COG1216	Glycosyl transferase, family 2
FDZ78_RS06110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FDZ78_RS06120	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FDZ78_RS06125	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FDZ78_RS06130	COG0713	ATP synthesis coupled electron transport
FDZ78_RS06135	COG0839	Belongs to the complex I subunit 6 family
FDZ78_RS06140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FDZ78_RS06145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FDZ78_RS06150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FDZ78_RS06160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FDZ78_RS06165	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FDZ78_RS06170	COG0356	it plays a direct role in the translocation of protons across the membrane
FDZ78_RS06185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FDZ78_RS06190	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FDZ78_RS06190	COG0649	NAD binding
FDZ78_RS06195	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FDZ78_RS06200	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FDZ78_RS06225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FDZ78_RS06230	COG1592	Rubrerythrin
FDZ78_RS06235	COG1028	Short-chain dehydrogenase reductase Sdr
FDZ78_RS06255	COG2814	Major facilitator Superfamily
FDZ78_RS06255	COG0477	Major facilitator Superfamily
FDZ78_RS06260	COG2115	Belongs to the xylose isomerase family
FDZ78_RS06265	COG1070	Carbohydrate kinase
FDZ78_RS06315	COG2096	Adenosyltransferase
FDZ78_RS06345	COG0180	Tryptophanyl-tRNA synthetase
FDZ78_RS06360	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FDZ78_RS06370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FDZ78_RS06375	COG0594	ribonuclease P activity
FDZ78_RS06415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FDZ78_RS06415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FDZ78_RS06420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FDZ78_RS06440	COG0438	transferase activity, transferring glycosyl groups
FDZ78_RS06460	COG1215	transferase activity, transferring glycosyl groups
FDZ78_RS06465	COG0438	transferase activity, transferring glycosyl groups
FDZ78_RS06485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FDZ78_RS06490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FDZ78_RS06515	COG0688	phosphatidylethanolamine metabolic process
FDZ78_RS06565	COG5433	transposase activity
FDZ78_RS06595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FDZ78_RS06615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FDZ78_RS06620	COG1022	Amp-dependent synthetase and ligase
FDZ78_RS06635	COG3118	belongs to the thioredoxin family
FDZ78_RS06655	COG4771	TonB-dependent receptor
FDZ78_RS06660	COG0039	L-malate dehydrogenase activity
FDZ78_RS06665	COG3118	belongs to the thioredoxin family
FDZ78_RS06665	COG0492	ferredoxin-NADP+ reductase activity
FDZ78_RS06685	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FDZ78_RS06690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FDZ78_RS06700	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FDZ78_RS06720	COG0531	amino acid
FDZ78_RS06740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FDZ78_RS06745	COG2226	methyltransferase
FDZ78_RS06755	COG0215	cysteine-tRNA ligase activity
FDZ78_RS06760	COG0668	transmembrane transport
FDZ78_RS06765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FDZ78_RS06770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FDZ78_RS06780	COG1215	transferase activity, transferring glycosyl groups
FDZ78_RS06785	COG1216	Glycosyl transferase, family 2
FDZ78_RS06800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FDZ78_RS06825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FDZ78_RS06835	COG2814	Major facilitator Superfamily
FDZ78_RS06850	COG0322	excinuclease ABC activity
FDZ78_RS06855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FDZ78_RS06860	COG0445	tRNA wobble uridine modification
FDZ78_RS06865	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FDZ78_RS06870	COG1619	proteins homologs of microcin C7 resistance protein MccF
FDZ78_RS06875	COG0731	radical SAM domain protein
FDZ78_RS06875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FDZ78_RS06880	COG0233	cytoplasmic translational termination
FDZ78_RS06885	COG0528	UMP kinase activity
FDZ78_RS06895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FDZ78_RS06900	COG0463	Glycosyl transferase, family 2
FDZ78_RS06905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FDZ78_RS06910	COG0495	leucyl-tRNA aminoacylation
FDZ78_RS06915	COG0336	Belongs to the RNA methyltransferase TrmD family
FDZ78_RS06920	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FDZ78_RS06920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FDZ78_RS06935	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FDZ78_RS06940	COG1785	Belongs to the alkaline phosphatase family
FDZ78_RS06980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FDZ78_RS06990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FDZ78_RS07005	COG4868	Belongs to the UPF0371 family
FDZ78_RS07070	COG0706	membrane insertase activity
FDZ78_RS07075	COG0504	CTP synthase activity
FDZ78_RS07080	COG1011	Hydrolase
FDZ78_RS07085	COG0196	riboflavin kinase activity
FDZ78_RS07115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FDZ78_RS07125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FDZ78_RS07155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FDZ78_RS07165	COG4771	TonB-dependent receptor
FDZ78_RS07175	COG0702	epimerase
FDZ78_RS07180	COG4771	TonB-dependent receptor
FDZ78_RS07215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FDZ78_RS07220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FDZ78_RS07235	COG2166	iron-sulfur cluster assembly
FDZ78_RS07245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FDZ78_RS07250	COG0489	protein tyrosine kinase activity
FDZ78_RS07265	COG1752	Esterase of the alpha-beta hydrolase superfamily
FDZ78_RS07310	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FDZ78_RS07340	COG0563	adenylate kinase activity
FDZ78_RS07350	COG3590	peptidase
FDZ78_RS07360	COG1757	Na H antiporter
FDZ78_RS07370	COG1410	methionine synthase
FDZ78_RS07370	COG0646	methionine synthase
FDZ78_RS07375	COG2755	lipolytic protein G-D-S-L family
FDZ78_RS07375	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FDZ78_RS07380	COG0217	transcriptional regulatory protein
FDZ78_RS07410	COG0793	Belongs to the peptidase S41A family
FDZ78_RS07410	COG3409	Peptidoglycan-binding domain 1 protein
FDZ78_RS07440	COG1773	rubredoxin
FDZ78_RS07440	COG1592	Rubrerythrin
FDZ78_RS07455	COG2151	metal-sulfur cluster biosynthetic enzyme
FDZ78_RS07460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FDZ78_RS07460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FDZ78_RS07475	COG0142	geranyltranstransferase activity
FDZ78_RS07480	COG1482	cell wall glycoprotein biosynthetic process
FDZ78_RS07495	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FDZ78_RS07500	COG0275	rRNA processing
FDZ78_RS07510	COG0768	penicillin binding
FDZ78_RS07515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FDZ78_RS07520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FDZ78_RS07525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FDZ78_RS07530	COG0772	Belongs to the SEDS family
FDZ78_RS07535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FDZ78_RS07540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FDZ78_RS07555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FDZ78_RS07560	COG3661	Belongs to the glycosyl hydrolase 67 family
FDZ78_RS07575	COG2211	Major facilitator Superfamily
FDZ78_RS07600	COG0561	phosphatase activity
FDZ78_RS07605	COG4771	TonB-dependent receptor
FDZ78_RS07610	COG0514	ATP-dependent DNA helicase (RecQ)
FDZ78_RS07615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FDZ78_RS07620	COG0668	transmembrane transport
FDZ78_RS07630	COG0572	uridine kinase
FDZ78_RS07645	COG0488	(ABC) transporter
FDZ78_RS07650	COG0242	peptide deformylase activity
FDZ78_RS07655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FDZ78_RS07660	COG2066	Belongs to the glutaminase family
FDZ78_RS07665	COG1082	Xylose isomerase domain protein TIM barrel
FDZ78_RS07715	COG2226	methyltransferase
FDZ78_RS07735	COG2116	formate transmembrane transporter activity
FDZ78_RS07740	COG0295	cytidine deaminase activity
FDZ78_RS07745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FDZ78_RS07755	COG1538	Outer membrane efflux protein
FDZ78_RS07765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FDZ78_RS07770	COG2223	nitrite transmembrane transporter activity
FDZ78_RS07775	COG1702	phosphate starvation-inducible protein PhoH
FDZ78_RS07795	COG0463	Glycosyl transferase, family 2
FDZ78_RS07820	COG1132	(ABC) transporter
FDZ78_RS07825	COG1522	sequence-specific DNA binding
FDZ78_RS07830	COG3250	beta-galactosidase activity
FDZ78_RS07860	COG0793	Belongs to the peptidase S41A family
FDZ78_RS07880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FDZ78_RS07890	COG0428	transporter
FDZ78_RS07895	COG1757	Na H antiporter
FDZ78_RS07900	COG3104	oligopeptide transport
FDZ78_RS07905	COG3104	oligopeptide transport
FDZ78_RS07915	COG1119	ATPase activity
FDZ78_RS07940	COG1760	l-serine dehydratase
FDZ78_RS07955	COG2239	Acts as a magnesium transporter
FDZ78_RS07960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FDZ78_RS07970	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FDZ78_RS07975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FDZ78_RS07990	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FDZ78_RS07995	COG0179	Fumarylacetoacetate (FAA) hydrolase
FDZ78_RS08000	COG3507	Belongs to the glycosyl hydrolase 43 family
FDZ78_RS08020	COG1196	nuclear chromosome segregation
FDZ78_RS08025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FDZ78_RS08035	COG0494	nUDIX hydrolase
FDZ78_RS08040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FDZ78_RS08045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FDZ78_RS08055	COG5002	protein histidine kinase activity
FDZ78_RS08060	COG0745	RESPONSE REGULATOR receiver
FDZ78_RS08090	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FDZ78_RS08150	COG4771	TonB-dependent receptor
FDZ78_RS08170	COG2755	lipolytic protein G-D-S-L family
FDZ78_RS08175	COG0813	purine-nucleoside phosphorylase activity
FDZ78_RS08180	COG0758	DNA mediated transformation
FDZ78_RS08180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FDZ78_RS08190	COG0318	PFAM AMP-dependent synthetase and ligase
FDZ78_RS08210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FDZ78_RS08225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FDZ78_RS08230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FDZ78_RS08235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FDZ78_RS08260	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FDZ78_RS08265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FDZ78_RS08265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FDZ78_RS08270	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FDZ78_RS08285	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FDZ78_RS08330	COG1940	carbohydrate kinase activity
FDZ78_RS08335	COG2255	four-way junction helicase activity
FDZ78_RS08350	COG2878	Part of a membrane complex involved in electron transport
FDZ78_RS08355	COG4656	Part of a membrane complex involved in electron transport
FDZ78_RS08365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FDZ78_RS08380	COG1595	DNA-templated transcription, initiation
FDZ78_RS08410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FDZ78_RS08415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FDZ78_RS08485	COG3247	response to pH
FDZ78_RS08505	COG0519	Catalyzes the synthesis of GMP from XMP
FDZ78_RS08505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FDZ78_RS08510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FDZ78_RS08525	COG0776	regulation of translation
FDZ78_RS08530	COG1530	ribonuclease E activity
FDZ78_RS08540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FDZ78_RS08550	COG4770	biotin carboxylase activity
FDZ78_RS08555	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FDZ78_RS08565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FDZ78_RS08570	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FDZ78_RS08575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FDZ78_RS08590	COG2885	chlorophyll binding
FDZ78_RS08595	COG0697	spore germination
FDZ78_RS08600	COG0823	Involved in the tonB-independent uptake of proteins
FDZ78_RS08600	COG1506	peptidase
FDZ78_RS08600	COG4946	Tricorn protease homolog
FDZ78_RS08615	COG0335	large ribosomal subunit rRNA binding
FDZ78_RS08640	COG0066	3-isopropylmalate dehydratase activity
FDZ78_RS08645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FDZ78_RS08650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FDZ78_RS08665	COG1442	glycosyl transferase family 8
FDZ78_RS08665	COG1216	Glycosyl transferase, family 2
FDZ78_RS08670	COG0438	transferase activity, transferring glycosyl groups
FDZ78_RS08675	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FDZ78_RS08680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FDZ78_RS08685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FDZ78_RS08690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FDZ78_RS08695	COG0358	DNA primase activity
FDZ78_RS08710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FDZ78_RS08715	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FDZ78_RS08735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FDZ78_RS08735	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FDZ78_RS08740	COG1121	(ABC) transporter
FDZ78_RS08750	COG0423	glycine-tRNA ligase activity
FDZ78_RS08760	COG0545	Peptidyl-prolyl cis-trans isomerase
FDZ78_RS08765	COG0343	queuine tRNA-ribosyltransferase activity
FDZ78_RS08780	COG3385	transposase activity
FDZ78_RS08785	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FDZ78_RS08790	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FDZ78_RS08795	COG1663	tetraacyldisaccharide 4'-kinase activity
FDZ78_RS08800	COG0616	signal peptide processing
FDZ78_RS08810	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FDZ78_RS08825	COG4771	TonB-dependent receptor
FDZ78_RS08830	COG0561	phosphatase activity
FDZ78_RS08845	COG4124	Belongs to the glycosyl hydrolase 26 family
FDZ78_RS08850	COG3459	Glycosyltransferase 36 associated
FDZ78_RS08855	COG4124	Belongs to the glycosyl hydrolase 26 family
FDZ78_RS08860	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
FDZ78_RS08865	COG2211	Major facilitator Superfamily
FDZ78_RS08870	COG2942	2-epimerase
FDZ78_RS08875	COG0826	peptidase U32
FDZ78_RS08885	COG0737	Belongs to the 5'-nucleotidase family
FDZ78_RS08900	COG3385	transposase activity
FDZ78_RS08920	COG0602	queuosine metabolic process
FDZ78_RS08930	COG0517	IMP dehydrogenase activity
FDZ78_RS08930	COG0617	tRNA 3'-terminal CCA addition
FDZ78_RS08930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FDZ78_RS08935	COG0006	proline dipeptidase activity
FDZ78_RS08955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FDZ78_RS08965	COG3876	Protein conserved in bacteria
FDZ78_RS08970	COG3275	phosphorelay sensor kinase activity
FDZ78_RS08975	COG3279	Response regulator of the LytR AlgR family
FDZ78_RS09005	COG2755	lipolytic protein G-D-S-L family
FDZ78_RS09005	COG0657	acetylesterase activity
FDZ78_RS09010	COG3250	beta-galactosidase activity
FDZ78_RS09020	COG0697	spore germination
FDZ78_RS09035	COG3385	transposase activity
FDZ78_RS09050	COG5433	transposase activity
FDZ78_RS09070	COG1501	Belongs to the glycosyl hydrolase 31 family
FDZ78_RS09080	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FDZ78_RS09085	COG4206	TonB-dependent receptor
FDZ78_RS09085	COG1629	transport
FDZ78_RS09100	COG1349	DNA-binding transcription factor activity
FDZ78_RS09105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FDZ78_RS09115	COG0247	lactate metabolic process
FDZ78_RS09120	COG2271	Major facilitator Superfamily
FDZ78_RS09135	COG1595	DNA-templated transcription, initiation
FDZ78_RS09150	COG0583	DNA-binding transcription factor activity
FDZ78_RS09165	COG1373	ATPase (AAA superfamily
FDZ78_RS09180	COG5433	transposase activity
FDZ78_RS09190	COG1484	DNA-dependent DNA replication
FDZ78_RS09250	COG4804	nuclease activity
FDZ78_RS09300	COG3385	transposase activity
FDZ78_RS09330	COG4335	DNA alkylation repair
FDZ78_RS09400	COG4974	Belongs to the 'phage' integrase family
FDZ78_RS09415	COG3385	transposase activity
FDZ78_RS09455	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FDZ78_RS09465	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FDZ78_RS09475	COG0440	acetolactate synthase activity
FDZ78_RS09480	COG0028	Belongs to the TPP enzyme family
FDZ78_RS09485	COG0129	dihydroxy-acid dehydratase activity
FDZ78_RS09495	COG0268	Binds directly to 16S ribosomal RNA
FDZ78_RS09525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FDZ78_RS09530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FDZ78_RS09535	COG3681	Belongs to the UPF0597 family
FDZ78_RS09540	COG0058	SHG alpha-glucan phosphorylase activity
FDZ78_RS09570	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FDZ78_RS09585	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FDZ78_RS09595	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FDZ78_RS09600	COG0811	peptide transport
FDZ78_RS09605	COG0848	biopolymer transport protein
FDZ78_RS09615	COG0742	ribosomal rna small subunit methyltransferase
FDZ78_RS09635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FDZ78_RS09640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FDZ78_RS09645	COG1083	cytidylyl-transferase
FDZ78_RS09650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FDZ78_RS09655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FDZ78_RS09660	COG0792	nuclease activity
FDZ78_RS09665	COG1228	amidohydrolase
FDZ78_RS09670	COG2986	histidine ammonia-lyase
FDZ78_RS09700	COG1610	YqeY-like protein
FDZ78_RS09705	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FDZ78_RS09710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FDZ78_RS09715	COG4591	ABC-type transport system involved in lipoprotein release permease component
FDZ78_RS09720	COG0662	Cupin 2, conserved barrel domain protein
FDZ78_RS09720	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FDZ78_RS09725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FDZ78_RS09730	COG0505	Belongs to the CarA family
FDZ78_RS09735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FDZ78_RS09740	COG0148	phosphopyruvate hydratase activity
FDZ78_RS09745	COG3385	transposase activity
FDZ78_RS09750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FDZ78_RS09755	COG0463	Glycosyl transferase, family 2
FDZ78_RS09755	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FDZ78_RS09765	COG0719	Fe-S assembly protein
FDZ78_RS09770	COG0396	ATPase activity
FDZ78_RS09790	COG1595	DNA-templated transcription, initiation
FDZ78_RS09800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FDZ78_RS09805	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FDZ78_RS09815	COG1185	polyribonucleotide nucleotidyltransferase activity
FDZ78_RS09820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FDZ78_RS09830	COG1242	4 iron, 4 sulfur cluster binding
FDZ78_RS09835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FDZ78_RS09840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FDZ78_RS09845	COG0489	protein tyrosine kinase activity
FDZ78_RS09845	COG3206	protein involved in exopolysaccharide biosynthesis
FDZ78_RS09860	COG0542	response to heat
FDZ78_RS09890	COG1805	sodium ion transport
FDZ78_RS09895	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FDZ78_RS09905	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FDZ78_RS09910	COG2871	sodium ion transport
FDZ78_RS09920	COG2873	o-acetylhomoserine
FDZ78_RS09930	COG3507	Belongs to the glycosyl hydrolase 43 family
FDZ78_RS09935	COG1501	Belongs to the glycosyl hydrolase 31 family
FDZ78_RS09945	COG2160	L-arabinose isomerase activity
FDZ78_RS09965	COG1136	(ABC) transporter
FDZ78_RS09965	COG0577	efflux transmembrane transporter activity
FDZ78_RS09990	COG3292	Two component regulator propeller
FDZ78_RS09990	COG0745	RESPONSE REGULATOR receiver
FDZ78_RS09990	COG2205	protein histidine kinase activity
FDZ78_RS10005	COG4206	TonB-dependent receptor
FDZ78_RS10005	COG1629	transport
FDZ78_RS10020	COG1472	Belongs to the glycosyl hydrolase 3 family
FDZ78_RS10025	COG3385	transposase activity
FDZ78_RS10075	COG1484	DNA-dependent DNA replication
FDZ78_RS10120	COG1032	radical SAM domain protein
FDZ78_RS10125	COG0556	nucleotide-excision repair
FDZ78_RS10130	COG0284	orotidine-5'-phosphate decarboxylase activity
FDZ78_RS10135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FDZ78_RS10145	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
FDZ78_RS10150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FDZ78_RS10160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FDZ78_RS10165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FDZ78_RS10165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FDZ78_RS10170	COG1979	alcohol dehydrogenase
FDZ78_RS10185	COG0254	rRNA binding
FDZ78_RS10200	COG1028	Short-chain dehydrogenase reductase Sdr
FDZ78_RS10220	COG3279	Response regulator of the LytR AlgR family
FDZ78_RS10230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FDZ78_RS10235	COG0052	Belongs to the universal ribosomal protein uS2 family
FDZ78_RS10240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FDZ78_RS10245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FDZ78_RS10255	COG0156	8-amino-7-oxononanoate synthase activity
FDZ78_RS10305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FDZ78_RS10310	COG0569	domain protein
FDZ78_RS10315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FDZ78_RS10320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FDZ78_RS10330	COG2195	Cleaves the N-terminal amino acid of tripeptides
FDZ78_RS10340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FDZ78_RS10345	COG1053	succinate dehydrogenase
FDZ78_RS10360	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FDZ78_RS10365	COG0459	protein refolding
FDZ78_RS10370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FDZ78_RS10385	COG1640	4-alpha-glucanotransferase
FDZ78_RS10390	COG0612	Peptidase, M16
FDZ78_RS10400	COG3956	TIGRFAM MazG family protein
FDZ78_RS10405	COG0484	heat shock protein binding
FDZ78_RS10410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FDZ78_RS10415	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FDZ78_RS10420	COG0305	Participates in initiation and elongation during chromosome replication
FDZ78_RS10440	COG1122	ATPase activity
FDZ78_RS10470	COG0424	maF-like protein
FDZ78_RS10515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FDZ78_RS10540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FDZ78_RS10555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FDZ78_RS10560	COG0626	cystathionine gamma-synthase activity
FDZ78_RS10565	COG0488	(ABC) transporter
FDZ78_RS10570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FDZ78_RS10590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FDZ78_RS10605	COG2755	lipolytic protein G-D-S-L family
FDZ78_RS10615	COG0359	binds to the 23S rRNA
FDZ78_RS10620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FDZ78_RS10625	COG0360	Binds together with S18 to 16S ribosomal RNA
FDZ78_RS10645	COG2197	response regulator
FDZ78_RS10670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FDZ78_RS10685	COG0778	Nitroreductase
FDZ78_RS10705	COG0438	transferase activity, transferring glycosyl groups
FDZ78_RS10710	COG2244	polysaccharide biosynthetic process
FDZ78_RS10720	COG1216	Glycosyl transferase, family 2
FDZ78_RS10730	COG0733	neurotransmitter:sodium symporter activity
FDZ78_RS10735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FDZ78_RS10745	COG0210	DNA helicase
FDZ78_RS10765	COG0513	Belongs to the DEAD box helicase family
FDZ78_RS10785	COG0501	Belongs to the peptidase M48B family
FDZ78_RS10800	COG3507	Belongs to the glycosyl hydrolase 43 family
FDZ78_RS10805	COG3507	Belongs to the glycosyl hydrolase 43 family
FDZ78_RS10820	COG0561	phosphatase activity
FDZ78_RS10825	COG4771	TonB-dependent receptor
FDZ78_RS10830	COG3507	Belongs to the glycosyl hydrolase 43 family
FDZ78_RS10835	COG3292	Two component regulator propeller
FDZ78_RS10835	COG2205	protein histidine kinase activity
FDZ78_RS10835	COG0745	RESPONSE REGULATOR receiver
FDZ78_RS10875	COG1091	dTDP-4-dehydrorhamnose reductase activity
FDZ78_RS10885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FDZ78_RS10895	COG1629	transport
FDZ78_RS10970	COG0481	GTPase activity
FDZ78_RS11010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FDZ78_RS11015	COG0126	phosphoglycerate kinase activity
FDZ78_RS11020	COG0432	Pfam Uncharacterised protein family UPF0047
FDZ78_RS11040	COG0583	DNA-binding transcription factor activity
FDZ78_RS11050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FDZ78_RS11055	COG1030	water channel activity
FDZ78_RS11080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FDZ78_RS11115	COG1595	DNA-templated transcription, initiation
FDZ78_RS11140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FDZ78_RS11150	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FDZ78_RS11185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FDZ78_RS11190	COG0436	Aminotransferase
FDZ78_RS11215	COG0592	DNA-directed DNA polymerase activity
FDZ78_RS11220	COG2176	DNA-directed DNA polymerase activity
FDZ78_RS11235	COG0497	DNA recombination
FDZ78_RS11240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FDZ78_RS11245	COG0116	Belongs to the methyltransferase superfamily
FDZ78_RS11245	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FDZ78_RS11250	COG1214	PFAM Peptidase M22, glycoprotease
FDZ78_RS11255	COG1561	YicC-like family, N-terminal region
FDZ78_RS11260	COG0194	GDP metabolic process
FDZ78_RS11265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FDZ78_RS11285	COG1380	Effector of murein hydrolase LrgA
FDZ78_RS11290	COG1346	cytolysis
FDZ78_RS11295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FDZ78_RS11300	COG1862	Preprotein translocase
FDZ78_RS11335	COG1215	transferase activity, transferring glycosyl groups
FDZ78_RS11345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FDZ78_RS11350	COG0517	IMP dehydrogenase activity
FDZ78_RS11350	COG0516	GMP reductase activity
FDZ78_RS11355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FDZ78_RS11360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FDZ78_RS11365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FDZ78_RS11370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FDZ78_RS11385	COG2205	protein histidine kinase activity
FDZ78_RS11385	COG2202	Pas domain
FDZ78_RS11390	COG0546	phosphoglycolate phosphatase activity
FDZ78_RS11415	COG1285	pathogenesis
FDZ78_RS11420	COG0475	glutathione-regulated potassium exporter activity
FDZ78_RS11445	COG2264	protein methyltransferase activity
FDZ78_RS11450	COG0659	secondary active sulfate transmembrane transporter activity
FDZ78_RS11455	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FDZ78_RS11460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FDZ78_RS11465	COG0131	Imidazoleglycerol-phosphate dehydratase
FDZ78_RS11470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FDZ78_RS11480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FDZ78_RS11490	COG0438	transferase activity, transferring glycosyl groups
FDZ78_RS11495	COG0438	transferase activity, transferring glycosyl groups
FDZ78_RS11515	COG0671	phosphoesterase, PA-phosphatase related
FDZ78_RS11520	COG0009	L-threonylcarbamoyladenylate synthase
FDZ78_RS11595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FDZ78_RS11605	COG0776	regulation of translation
FDZ78_RS11610	COG0085	RNA polymerase activity
FDZ78_RS11770	COG2003	Belongs to the UPF0758 family
FDZ78_RS11800	COG0574	Belongs to the PEP-utilizing enzyme family
FDZ78_RS11800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FDZ78_RS11810	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FDZ78_RS11810	COG1918	ferrous iron import across plasma membrane
FDZ78_RS11820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FDZ78_RS11835	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FDZ78_RS11845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FDZ78_RS11850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FDZ78_RS11855	COG0512	Glutamine amidotransferase of anthranilate synthase
FDZ78_RS11865	COG0067	glutamate synthase
FDZ78_RS11865	COG0069	glutamate synthase activity
FDZ78_RS11865	COG0070	glutamate synthase
FDZ78_RS11870	COG0004	ammonium transporteR
FDZ78_RS11885	COG2183	response to ionizing radiation
FDZ78_RS11895	COG4452	Inner membrane protein CreD
FDZ78_RS11905	COG2333	competence protein COMEC
FDZ78_RS11905	COG0658	competence protein
FDZ78_RS11910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FDZ78_RS11940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FDZ78_RS11940	COG0140	phosphoribosyl-ATP diphosphatase activity
FDZ78_RS11945	COG0107	imidazoleglycerol-phosphate synthase activity
FDZ78_RS11955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FDZ78_RS11985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FDZ78_RS11990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FDZ78_RS11995	COG0515	serine threonine protein kinase
FDZ78_RS11995	COG2815	serine threonine protein kinase
FDZ78_RS12000	COG0564	pseudouridine synthase activity
FDZ78_RS12015	COG1968	undecaprenyl-diphosphatase activity
FDZ78_RS12020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FDZ78_RS12025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FDZ78_RS12030	COG1739	Uncharacterized protein family UPF0029
FDZ78_RS12050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FDZ78_RS12095	COG0563	adenylate kinase activity
FDZ78_RS12105	COG4974	Belongs to the 'phage' integrase family
FDZ78_RS12215	COG3209	COG3209 Rhs family protein
FDZ78_RS12355	COG3392	D12 class N6 adenine-specific DNA methyltransferase
FDZ78_RS12365	COG5433	transposase activity
FDZ78_RS12430	COG3023	N-Acetylmuramoyl-L-alanine amidase
FDZ78_RS12465	COG1484	DNA-dependent DNA replication
FDZ78_RS12490	COG0582	viral genome integration into host DNA
FDZ78_RS12515	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FDZ78_RS12580	COG0572	uridine kinase
FDZ78_RS12595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FDZ78_RS12600	COG0193	aminoacyl-tRNA hydrolase activity
FDZ78_RS12605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FDZ78_RS12635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FDZ78_RS12645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FDZ78_RS12650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FDZ78_RS12655	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FDZ78_RS12680	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FDZ78_RS12700	COG4206	TonB-dependent receptor
FDZ78_RS12700	COG1629	transport
FDZ78_RS12710	COG3118	belongs to the thioredoxin family
FDZ78_RS12720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FDZ78_RS12730	COG0791	NLP P60 protein
FDZ78_RS12840	COG1475	DNA binding
FDZ78_RS12865	COG0202	RNA polymerase activity
FDZ78_RS12910	COG0110	maltose O-acetyltransferase activity
FDZ78_RS12975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FDZ78_RS12985	COG0110	maltose O-acetyltransferase activity
FDZ78_RS12995	COG0438	transferase activity, transferring glycosyl groups
FDZ78_RS13010	COG0438	transferase activity, transferring glycosyl groups
FDZ78_RS13015	COG3594	Acyltransferase
FDZ78_RS13025	COG1216	Glycosyl transferase, family 2
FDZ78_RS13045	COG2244	polysaccharide biosynthetic process
FDZ78_RS13110	COG1484	DNA-dependent DNA replication
FDZ78_RS13130	COG0612	Peptidase, M16
FDZ78_RS13135	COG0791	NLP P60 protein
FDZ78_RS13140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FDZ78_RS13145	COG0251	oxidation-reduction process
FDZ78_RS13150	COG1959	2 iron, 2 sulfur cluster binding
FDZ78_RS13150	COG1295	ribonuclease BN
FDZ78_RS13165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FDZ78_RS13180	COG2204	response regulator
FDZ78_RS13195	COG0577	efflux transmembrane transporter activity
FDZ78_RS13200	COG1136	(ABC) transporter
FDZ78_RS13210	COG0577	efflux transmembrane transporter activity
FDZ78_RS13220	COG0628	permease
FDZ78_RS13235	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FDZ78_RS13240	COG0436	Aminotransferase
FDZ78_RS13250	COG1074	ATP-dependent DNA helicase activity
FDZ78_RS13255	COG0023	Translation Initiation Factor
FDZ78_RS13270	COG0167	dihydroorotate dehydrogenase activity
FDZ78_RS13275	COG0543	2 iron, 2 sulfur cluster binding
FDZ78_RS13295	COG0778	Nitroreductase
FDZ78_RS13315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FDZ78_RS13320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FDZ78_RS13325	COG1592	Rubrerythrin
FDZ78_RS13330	COG1592	Rubrerythrin
FDZ78_RS13360	COG0670	Belongs to the BI1 family
FDZ78_RS13365	COG0018	arginyl-trna synthetase
FDZ78_RS13370	COG1252	NADH dehydrogenase
FDZ78_RS13375	COG2884	Cell division ATP-binding protein ftsE
FDZ78_RS13380	COG0514	ATP-dependent DNA helicase (RecQ)
FDZ78_RS13385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FDZ78_RS13390	COG0740	serine-type endopeptidase activity
FDZ78_RS13405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FDZ78_RS13410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FDZ78_RS13425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FDZ78_RS13460	COG5433	transposase activity
FDZ78_RS13505	COG0632	four-way junction helicase activity
FDZ78_RS13515	COG0564	pseudouridine synthase activity
FDZ78_RS13530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FDZ78_RS13540	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FDZ78_RS13545	COG2086	electron transfer activity
FDZ78_RS13550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FDZ78_RS13550	COG0047	phosphoribosylformylglycinamidine synthase activity
FDZ78_RS13555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FDZ78_RS13560	COG0157	Belongs to the NadC ModD family
FDZ78_RS13565	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FDZ78_RS13570	COG1181	Belongs to the D-alanine--D-alanine ligase family
FDZ78_RS13575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FDZ78_RS13615	COG5433	transposase activity
FDZ78_RS13620	COG3385	transposase activity
FDZ78_RS13650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FDZ78_RS13665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FDZ78_RS13720	COG0714	Associated with various cellular activities
FDZ78_RS13735	COG0463	Glycosyl transferase, family 2
FDZ78_RS13740	COG0442	prolyl-tRNA aminoacylation
FDZ78_RS13745	COG2885	chlorophyll binding
FDZ78_RS13755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FDZ78_RS13765	COG1028	Short-chain dehydrogenase reductase Sdr
FDZ78_RS13770	COG1309	transcriptional regulator
FDZ78_RS13790	COG0629	single-stranded DNA binding
FDZ78_RS13810	COG0737	Belongs to the 5'-nucleotidase family
FDZ78_RS13815	COG2720	vancomycin resistance protein
FDZ78_RS13825	COG4864	UPF0365 protein
FDZ78_RS13840	COG0543	2 iron, 2 sulfur cluster binding
FDZ78_RS13870	COG4566	intracellular signal transduction
FDZ78_RS13875	COG0302	gtp cyclohydrolase
FDZ78_RS13885	COG0149	triose-phosphate isomerase activity
FDZ78_RS13890	COG5433	transposase activity
FDZ78_RS13915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FDZ78_RS13920	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FDZ78_RS13925	COG0187	DNA topoisomerase II activity
FDZ78_RS13930	COG0557	exoribonuclease II activity
FDZ78_RS13940	COG0084	hydrolase, TatD family'
FDZ78_RS13950	COG1966	Carbon starvation protein
FDZ78_RS13960	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FDZ78_RS13980	COG0575	Belongs to the CDS family
FDZ78_RS13990	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FDZ78_RS14015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FDZ78_RS14025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FDZ78_RS14035	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FDZ78_RS14040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FDZ78_RS14055	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FDZ78_RS14065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FDZ78_RS14070	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FDZ78_RS14075	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FDZ78_RS14080	COG0509	glycine decarboxylation via glycine cleavage system
FDZ78_RS14085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FDZ78_RS14125	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FDZ78_RS14125	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FDZ78_RS14130	COG3852	Histidine kinase
FDZ78_RS14140	COG2890	protein-(glutamine-N5) methyltransferase activity
FDZ78_RS14175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FDZ78_RS14180	COG0174	glutamine synthetase
FDZ78_RS14190	COG3158	transport of potassium into the cell
FDZ78_RS14205	COG0823	Involved in the tonB-independent uptake of proteins
FDZ78_RS14205	COG1506	peptidase
FDZ78_RS14205	COG4946	Tricorn protease homolog
FDZ78_RS14240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FDZ78_RS14245	COG0741	lytic transglycosylase activity
FDZ78_RS14245	COG1388	LysM domain
FDZ78_RS14255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FDZ78_RS14295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FDZ78_RS14300	COG0552	protein localization to endoplasmic reticulum
FDZ78_RS14315	COG0523	cobalamin synthesis protein
FDZ78_RS14320	COG0488	(ABC) transporter
FDZ78_RS14335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FDZ78_RS14385	COG1063	alcohol dehydrogenase
FDZ78_RS14495	COG3023	N-Acetylmuramoyl-L-alanine amidase