locus-tag	class	description
I6G97_RS00160	COG1192	Involved in chromosome partitioning
I6G97_RS00315	COG0650	Formate hydrogenlyase subunit 4
I6G97_RS00320	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6G97_RS00320	COG3261	NADH dehydrogenase
I6G97_RS00325	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G97_RS00330	COG3260	NADH ubiquinone oxidoreductase 20
I6G97_RS00340	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G97_RS00350	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G97_RS00355	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6G97_RS00360	COG0375	protein maturation
I6G97_RS00365	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6G97_RS00370	COG0298	carbon dioxide binding
I6G97_RS00375	COG0409	Hydrogenase expression formation protein
I6G97_RS00380	COG0309	Hydrogenase expression formation protein (HypE)
I6G97_RS00400	COG0583	DNA-binding transcription factor activity
I6G97_RS00405	COG3119	arylsulfatase activity
I6G97_RS00430	COG1560	Kdo2-lipid A biosynthetic process
I6G97_RS00435	COG3133	Outer membrane lipoprotein
I6G97_RS00540	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G97_RS00540	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G97_RS00615	COG4397	Mu-like prophage major head subunit gpT
I6G97_RS00635	COG2369	cell adhesion
I6G97_RS00640	COG4383	Mu-like prophage protein gp29
I6G97_RS00755	COG2842	Transposition protein
I6G97_RS00775	COG3210	domain, Protein
I6G97_RS00780	COG2831	hemolysin activation secretion protein
I6G97_RS00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G97_RS00820	COG4974	Belongs to the 'phage' integrase family
I6G97_RS00825	COG0716	FMN binding
I6G97_RS00835	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6G97_RS00845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G97_RS00850	COG3248	Nucleoside-binding outer membrane protein
I6G97_RS00855	COG1272	protein, Hemolysin III
I6G97_RS00860	COG1115	amino acid carrier protein
I6G97_RS00880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G97_RS00885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G97_RS00890	COG0006	proline dipeptidase activity
I6G97_RS00910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G97_RS00915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G97_RS00935	COG1279	arginine transmembrane transporter activity
I6G97_RS00950	COG0126	phosphoglycerate kinase activity
I6G97_RS00960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G97_RS00965	COG3119	arylsulfatase activity
I6G97_RS00975	COG1166	arginine decarboxylase activity
I6G97_RS00990	COG2814	Major facilitator Superfamily
I6G97_RS00995	COG0312	modulator of DNA gyrase
I6G97_RS01000	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6G97_RS01010	COG2732	(Barnase) inhibitor
I6G97_RS01020	COG2723	6-phospho-beta-galactosidase activity
I6G97_RS01040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G97_RS01045	COG0583	DNA-binding transcription factor activity
I6G97_RS01050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G97_RS01055	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G97_RS01080	COG2211	Major facilitator Superfamily
I6G97_RS01085	COG2211	Major facilitator Superfamily
I6G97_RS01110	COG1294	oxidase, subunit
I6G97_RS01115	COG1271	oxidase subunit
I6G97_RS01125	COG1773	rubredoxin
I6G97_RS01130	COG1999	signal sequence binding
I6G97_RS01135	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G97_RS01140	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6G97_RS01150	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6G97_RS01160	COG1982	Orn Lys Arg decarboxylase major
I6G97_RS01165	COG0531	amino acid
I6G97_RS01175	COG2223	nitrite transmembrane transporter activity
I6G97_RS01180	COG3279	Response regulator of the LytR AlgR family
I6G97_RS01185	COG3275	phosphorelay sensor kinase activity
I6G97_RS01190	COG1486	melibiose metabolic process
I6G97_RS01195	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G97_RS01200	COG1129	ABC transporter
I6G97_RS01220	COG2271	Major facilitator Superfamily
I6G97_RS01225	COG1414	Transcriptional regulator
I6G97_RS01230	COG1609	Transcriptional regulator
I6G97_RS01235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G97_RS01245	COG3037	sugar-specific permease SgaT UlaA
I6G97_RS01275	COG3177	Filamentation induced by cAMP protein fic
I6G97_RS01285	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6G97_RS01335	COG1376	ErfK ybiS ycfS ynhG family protein
I6G97_RS01340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G97_RS01345	COG0795	lipopolysaccharide-transporting ATPase activity
I6G97_RS01350	COG0795	lipopolysaccharide-transporting ATPase activity
I6G97_RS01360	COG2927	DNA polymerase III (CHI subunit)
I6G97_RS01370	COG4176	ABC-type proline glycine betaine transport system permease component
I6G97_RS01375	COG1116	anion transmembrane transporter activity
I6G97_RS01395	COG2731	YhcH YjgK YiaL family protein
I6G97_RS01400	COG0247	lactate metabolic process
I6G97_RS01410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G97_RS01415	COG2271	Major facilitator Superfamily
I6G97_RS01420	COG0584	glycerophosphoryl diester phosphodiesterase
I6G97_RS01425	COG0625	glutathione transferase activity
I6G97_RS01435	COG3276	selenocysteine insertion sequence binding
I6G97_RS01440	COG1012	belongs to the aldehyde dehydrogenase family
I6G97_RS01445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G97_RS01460	COG0540	Belongs to the ATCase OTCase family
I6G97_RS01470	COG0312	modulator of DNA gyrase
I6G97_RS01475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G97_RS01480	COG3164	Protein of unknown function
I6G97_RS01495	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6G97_RS01500	COG1792	Involved in formation and maintenance of cell shape
I6G97_RS01505	COG1077	Cell shape determining protein MreB Mrl
I6G97_RS01510	COG2200	EAL domain
I6G97_RS01510	COG2199	diguanylate cyclase activity
I6G97_RS01515	COG0604	alcohol dehydrogenase
I6G97_RS01520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6G97_RS01535	COG0511	ligase activity, forming carbon-carbon bonds
I6G97_RS01540	COG0439	Biotin carboxylase
I6G97_RS01545	COG3924	membrane
I6G97_RS01550	COG4145	pantothenate transmembrane transporter activity
I6G97_RS01590	COG1132	(ABC) transporter
I6G97_RS01635	COG1346	cytolysis
I6G97_RS01640	COG1380	Effector of murein hydrolase LrgA
I6G97_RS01645	COG0583	DNA-binding transcription factor activity
I6G97_RS01650	COG0025	NhaP-type Na H and K H
I6G97_RS01655	COG2252	PERMEase
I6G97_RS01660	COG0402	S-adenosylhomocysteine deaminase activity
I6G97_RS01665	COG2233	PERMEase
I6G97_RS01670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G97_RS01670	COG2080	2 iron, 2 sulfur cluster binding
I6G97_RS01675	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6G97_RS01680	COG0402	S-adenosylhomocysteine deaminase activity
I6G97_RS01685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G97_RS01685	COG0493	'glutamate synthase
I6G97_RS01690	COG2068	MobA-Related Protein
I6G97_RS01695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G97_RS01700	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6G97_RS01700	COG3608	succinylglutamate desuccinylase aspartoacylase
I6G97_RS01705	COG0549	Belongs to the carbamate kinase family
I6G97_RS01715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G97_RS01720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G97_RS01725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G97_RS01730	COG3829	transcription factor binding
I6G97_RS01745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G97_RS01750	COG2315	Protein conserved in bacteria
I6G97_RS01755	COG0432	Pfam Uncharacterised protein family UPF0047
I6G97_RS01760	COG1448	Aminotransferase
I6G97_RS01765	COG0656	L-ascorbic acid biosynthetic process
I6G97_RS01825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G97_RS01840	COG0009	L-threonylcarbamoyladenylate synthase
I6G97_RS01845	COG0551	DNA topoisomerase type I activity
I6G97_RS01850	COG2922	Belongs to the Smg family
I6G97_RS01855	COG0758	DNA mediated transformation
I6G97_RS01870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G97_RS01870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G97_RS01875	COG0569	domain protein
I6G97_RS01880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G97_RS01885	COG1970	mechanosensitive ion channel activity
I6G97_RS01890	COG0789	Transcriptional regulator
I6G97_RS01920	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G97_RS01925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G97_RS01930	COG0201	protein transport
I6G97_RS02005	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6G97_RS02030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G97_RS02035	COG0051	transcription antitermination factor activity, RNA binding
I6G97_RS02060	COG2168	tRNA wobble position uridine thiolation
I6G97_RS02075	COG2964	Protein conserved in bacteria
I6G97_RS02080	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G97_RS02090	COG1047	Peptidyl-prolyl cis-trans
I6G97_RS02095	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6G97_RS02105	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G97_RS02110	COG0488	(ABC) transporter
I6G97_RS02125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G97_RS02135	COG0402	S-adenosylhomocysteine deaminase activity
I6G97_RS02140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6G97_RS02160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G97_RS02180	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G97_RS02185	COG4796	Type ii and iii secretion system protein
I6G97_RS02205	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6G97_RS02210	COG0494	nUDIX hydrolase
I6G97_RS02220	COG1011	Hydrolase
I6G97_RS02225	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G97_RS02235	COG0437	4 iron, 4 sulfur cluster binding
I6G97_RS02240	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6G97_RS02245	COG0484	heat shock protein binding
I6G97_RS02270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G97_RS02275	COG2183	response to ionizing radiation
I6G97_RS02280	COG1918	ferrous iron import across plasma membrane
I6G97_RS02285	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6G97_RS02300	COG1040	competence protein
I6G97_RS02310	COG1289	transmembrane transporter activity
I6G97_RS02315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G97_RS02325	COG0429	hydrolase of the alpha beta-hydrolase fold
I6G97_RS02335	COG2909	trisaccharide binding
I6G97_RS02340	COG0058	SHG alpha-glucan phosphorylase activity
I6G97_RS02345	COG1640	4-alpha-glucanotransferase
I6G97_RS02350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G97_RS02355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G97_RS02360	COG1523	belongs to the glycosyl hydrolase 13 family
I6G97_RS02365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G97_RS02375	COG0058	SHG alpha-glucan phosphorylase activity
I6G97_RS02380	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G97_RS02385	COG1349	DNA-binding transcription factor activity
I6G97_RS02390	COG0705	Rhomboid family
I6G97_RS02405	COG0584	glycerophosphoryl diester phosphodiesterase
I6G97_RS02415	COG0395	ABC-type sugar transport system, permease component
I6G97_RS02420	COG1175	transmembrane transport
I6G97_RS02430	COG0456	acetyltransferase
I6G97_RS02435	COG1929	Belongs to the glycerate kinase type-1 family
I6G97_RS02440	COG2610	gluconate transmembrane transporter activity
I6G97_RS02445	COG3835	regulator
I6G97_RS02455	COG2177	Part of the ABC transporter FtsEX involved in
I6G97_RS02460	COG2884	Cell division ATP-binding protein ftsE
I6G97_RS02465	COG0552	protein localization to endoplasmic reticulum
I6G97_RS02465	COG0552	protein localization to endoplasmic reticulum
I6G97_RS02470	COG0742	ribosomal rna small subunit methyltransferase
I6G97_RS02475	COG3776	membrane
I6G97_RS02490	COG3714	YhhN family
I6G97_RS02495	COG2258	MOSC domain
I6G97_RS02500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G97_RS02510	COG0437	4 iron, 4 sulfur cluster binding
I6G97_RS02515	COG2864	formate dehydrogenase
I6G97_RS02525	COG0561	phosphatase activity
I6G97_RS02530	COG2267	carboxylic ester hydrolase activity
I6G97_RS02535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G97_RS02540	COG3275	phosphorelay sensor kinase activity
I6G97_RS02550	COG0306	phosphate transporter
I6G97_RS02555	COG0733	neurotransmitter:sodium symporter activity
I6G97_RS02565	COG0589	response to stress
I6G97_RS02580	COG2205	protein histidine kinase activity
I6G97_RS02585	COG0745	RESPONSE REGULATOR receiver
I6G97_RS02595	COG1129	ABC transporter
I6G97_RS02600	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G97_RS02610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G97_RS02615	COG0517	IMP dehydrogenase activity
I6G97_RS02615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G97_RS02625	COG0339	signal peptide processing
I6G97_RS02635	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6G97_RS02640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G97_RS02655	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G97_RS02665	COG0583	DNA-binding transcription factor activity
I6G97_RS02670	COG2134	cdp-diacylglycerol pyrophosphatase
I6G97_RS02725	COG0582	viral genome integration into host DNA
I6G97_RS02735	COG2200	EAL domain
I6G97_RS02740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G97_RS02745	COG0612	Peptidase, M16
I6G97_RS02755	COG2200	EAL domain
I6G97_RS02755	COG2199	diguanylate cyclase activity
I6G97_RS02760	COG3118	belongs to the thioredoxin family
I6G97_RS02760	COG0457	Tetratricopeptide repeat
I6G97_RS02765	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6G97_RS02770	COG1215	transferase activity, transferring glycosyl groups
I6G97_RS02780	COG1192	Involved in chromosome partitioning
I6G97_RS02805	COG4608	Belongs to the ABC transporter superfamily
I6G97_RS02810	COG0444	Belongs to the ABC transporter superfamily
I6G97_RS02815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G97_RS02820	COG0601	transmembrane transport
I6G97_RS02825	COG0747	negative chemotaxis
I6G97_RS02830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G97_RS02845	COG2271	Major facilitator Superfamily
I6G97_RS02855	COG2197	response regulator
I6G97_RS02860	COG0840	transmembrane signaling receptor activity
I6G97_RS02865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G97_RS02870	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6G97_RS02875	COG2207	Transcriptional regulator
I6G97_RS02945	COG0582	viral genome integration into host DNA
I6G97_RS02955	COG0527	aspartate kinase activity
I6G97_RS02955	COG0460	homoserine dehydrogenase
I6G97_RS02960	COG0626	cystathionine gamma-synthase activity
I6G97_RS02980	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G97_RS02985	COG1609	Transcriptional regulator
I6G97_RS02990	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G97_RS02995	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6G97_RS03005	COG1575	Belongs to the MenA family. Type 1 subfamily
I6G97_RS03020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G97_RS03030	COG1494	fructose-1,6-bisphosphatase
I6G97_RS03035	COG2814	Major facilitator Superfamily
I6G97_RS03050	COG3152	Membrane
I6G97_RS03060	COG0149	triose-phosphate isomerase activity
I6G97_RS03070	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G97_RS03080	COG3678	ATP-independent chaperone mediated protein folding
I6G97_RS03085	COG0745	RESPONSE REGULATOR receiver
I6G97_RS03090	COG2205	protein histidine kinase activity
I6G97_RS03095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G97_RS03100	COG1045	serine acetyltransferase
I6G97_RS03115	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G97_RS03120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G97_RS03130	COG4942	peptidase
I6G97_RS03135	COG2861	carbohydrate metabolic process
I6G97_RS03140	COG2860	membrane
I6G97_RS03145	COG0194	GDP metabolic process
I6G97_RS03155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G97_RS03160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G97_RS03165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G97_RS03170	COG0786	glutamate:sodium symporter activity
I6G97_RS03175	COG2233	PERMEase
I6G97_RS03180	COG2982	Protein involved in outer membrane biogenesis
I6G97_RS03195	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6G97_RS03205	COG2885	chlorophyll binding
I6G97_RS03210	COG2119	membrane
I6G97_RS03220	COG2818	Glycosylase
I6G97_RS03240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G97_RS03240	COG2213	PTS system mannitol-specific
I6G97_RS03245	COG0246	Mannitol dehydrogenase
I6G97_RS03250	COG3722	fumarate hydratase activity
I6G97_RS03255	COG3977	Valine--pyruvate aminotransferase
I6G97_RS03265	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G97_RS03270	COG5645	(Lipo)protein
I6G97_RS03275	COG0823	Involved in the tonB-independent uptake of proteins
I6G97_RS03280	COG0561	phosphatase activity
I6G97_RS03285	COG0187	DNA topoisomerase II activity
I6G97_RS03295	COG0592	DNA-directed DNA polymerase activity
I6G97_RS03330	COG2840	Smr protein MutS2
I6G97_RS03335	COG0398	Pfam SNARE associated Golgi protein
I6G97_RS03345	COG2252	PERMEase
I6G97_RS03355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G97_RS03370	COG0581	inorganic phosphate transmembrane transporter activity
I6G97_RS03375	COG0573	inorganic phosphate transmembrane transporter activity
I6G97_RS03380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G97_RS03425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6G97_RS03440	COG3312	ion transport
I6G97_RS03455	COG0716	FMN binding
I6G97_RS03460	COG1522	sequence-specific DNA binding
I6G97_RS03480	COG3158	transport of potassium into the cell
I6G97_RS03490	COG1129	ABC transporter
I6G97_RS03495	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G97_RS03500	COG1879	ABC-type sugar transport system periplasmic component
I6G97_RS03505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G97_RS03510	COG1609	Transcriptional regulator
I6G97_RS03515	COG0477	Major facilitator Superfamily
I6G97_RS03520	COG2186	Transcriptional regulator
I6G97_RS03560	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6G97_RS03565	COG0746	molybdenum cofactor guanylyltransferase activity
I6G97_RS03570	COG3084	Protein conserved in bacteria
I6G97_RS03575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G97_RS03580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G97_RS03585	COG0204	Acyl-transferase
I6G97_RS03590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G97_RS03590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G97_RS03635	COG1217	gtp-binding protein TYPA
I6G97_RS03640	COG1011	Hydrolase
I6G97_RS03645	COG1295	ribonuclease BN
I6G97_RS03660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G97_RS03700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G97_RS03700	COG0678	peroxiredoxin activity
I6G97_RS03710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G97_RS03715	COG1309	transcriptional regulator
I6G97_RS03740	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6G97_RS03750	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G97_RS03790	COG3085	chromosome segregation
I6G97_RS03795	COG1561	YicC-like family, N-terminal region
I6G97_RS03815	COG0756	dUTP diphosphatase activity
I6G97_RS03820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G97_RS03825	COG2003	Belongs to the UPF0758 family
I6G97_RS03855	COG1519	Transferase
I6G97_RS03860	COG0438	transferase activity, transferring glycosyl groups
I6G97_RS03870	COG0859	PFAM glycosyl transferase family 9
I6G97_RS03890	COG3307	-O-antigen
I6G97_RS03900	COG0859	PFAM glycosyl transferase family 9
I6G97_RS03915	COG0156	8-amino-7-oxononanoate synthase activity
I6G97_RS03940	COG3978	acetolactate synthase activity
I6G97_RS03945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G97_RS03970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G97_RS03975	COG0210	DNA helicase
I6G97_RS03980	COG0248	Ppx GppA phosphatase
I6G97_RS03990	COG3118	belongs to the thioredoxin family
I6G97_RS04000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G97_RS04010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6G97_RS04015	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6G97_RS04020	COG1088	dTDP-glucose 4,6-dehydratase activity
I6G97_RS04025	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6G97_RS04030	COG0456	acetyltransferase
I6G97_RS04035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G97_RS04040	COG2244	polysaccharide biosynthetic process
I6G97_RS04045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G97_RS04055	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6G97_RS04080	COG3071	HemY protein
I6G97_RS04085	COG2959	enzyme of heme biosynthesis
I6G97_RS04090	COG1587	Uroporphyrinogen-III synthase
I6G97_RS04095	COG0181	hydroxymethylbilane synthase activity
I6G97_RS04110	COG5567	small periplasmic lipoprotein
I6G97_RS04120	COG3159	Protein conserved in bacteria
I6G97_RS04130	COG1011	Hydrolase
I6G97_RS04135	COG0210	DNA helicase
I6G97_RS04140	COG0598	Magnesium transport protein CorA
I6G97_RS04145	COG3180	Ammonia monooxygenase
I6G97_RS04155	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6G97_RS04170	COG1280	lysine exporter protein (LysE YggA)
I6G97_RS04175	COG2610	gluconate transmembrane transporter activity
I6G97_RS04180	COG3265	gluconokinase activity
I6G97_RS04185	COG1609	Transcriptional regulator
I6G97_RS04220	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G97_RS04230	COG1966	Carbon starvation protein
I6G97_RS04235	COG0586	Pfam SNARE associated Golgi protein
I6G97_RS04240	COG1322	Protein conserved in bacteria
I6G97_RS04260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G97_RS04265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G97_RS04270	COG0805	protein transport
I6G97_RS04310	COG1739	Uncharacterized protein family UPF0029
I6G97_RS04315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G97_RS04350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6G97_RS04395	COG0250	Participates in transcription elongation, termination and antitermination
I6G97_RS04415	COG0222	ribosome binding
I6G97_RS04425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G97_RS04450	COG3068	Protein conserved in bacteria
I6G97_RS04465	COG0151	Belongs to the GarS family
I6G97_RS04495	COG1584	GPR1 FUN34 yaaH family protein
I6G97_RS04500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G97_RS04505	COG1301	dicarboxylic acid transport
I6G97_RS04510	COG1538	Outer membrane efflux protein
I6G97_RS04515	COG0494	nUDIX hydrolase
I6G97_RS04520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G97_RS04525	COG3150	esterase
I6G97_RS04535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G97_RS04555	COG0527	aspartate kinase activity
I6G97_RS04575	COG3833	ABC-type maltose transport systems, permease component
I6G97_RS04580	COG1175	transmembrane transport
I6G97_RS04585	COG2182	Extracellular solute-binding protein
I6G97_RS04615	COG2223	nitrite transmembrane transporter activity
I6G97_RS04625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G97_RS04630	COG0471	metal ion transport
I6G97_RS04645	COG3051	citrate lyase alpha subunit
I6G97_RS04650	COG2301	Belongs to the HpcH HpaI aldolase family
I6G97_RS04660	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6G97_RS04665	COG3290	protein histidine kinase activity
I6G97_RS04670	COG4565	transcriptional regulatory protein
I6G97_RS04680	COG0534	Mate efflux family protein
I6G97_RS04685	COG0735	belongs to the Fur family
I6G97_RS04695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G97_RS04720	COG1979	alcohol dehydrogenase
I6G97_RS04725	COG2207	Transcriptional regulator
I6G97_RS04745	COG0840	transmembrane signaling receptor activity
I6G97_RS04755	COG2181	nitrate reductase activity
I6G97_RS04760	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G97_RS04765	COG1140	nitrate reductase beta subunit
I6G97_RS04770	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G97_RS04775	COG2223	nitrite transmembrane transporter activity
I6G97_RS04780	COG0471	metal ion transport
I6G97_RS04785	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6G97_RS04790	COG1263	PTS System
I6G97_RS04790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G97_RS04800	COG0456	acetyltransferase
I6G97_RS04815	COG1982	Orn Lys Arg decarboxylase major
I6G97_RS04820	COG0531	amino acid
I6G97_RS04840	COG1194	a g-specific adenine glycosylase
I6G97_RS04850	COG3171	Protein conserved in bacteria
I6G97_RS04870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G97_RS04885	COG0762	integral membrane protein
I6G97_RS04890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G97_RS04900	COG1678	Uncharacterized ACR, COG1678
I6G97_RS04905	COG0189	ligase activity
I6G97_RS04910	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G97_RS04915	COG2356	endonuclease I
I6G97_RS04920	COG3091	SprT-like family
I6G97_RS04925	COG0531	amino acid
I6G97_RS04935	COG0754	glutathionylspermidine amidase activity
I6G97_RS04940	COG5463	Belongs to the UPF0441 family
I6G97_RS04945	COG1349	DNA-binding transcription factor activity
I6G97_RS04965	COG0738	Major facilitator superfamily
I6G97_RS04975	COG0235	Class ii aldolase
I6G97_RS04980	COG1454	alcohol dehydrogenase
I6G97_RS04985	COG3247	response to pH
I6G97_RS04990	COG3781	membrane
I6G97_RS05005	COG3005	denitrification pathway
I6G97_RS05010	COG0745	RESPONSE REGULATOR receiver
I6G97_RS05015	COG1879	ABC-type sugar transport system periplasmic component
I6G97_RS05020	COG2205	protein histidine kinase activity
I6G97_RS05020	COG0784	Response regulator, receiver
I6G97_RS05020	COG2198	Histidine kinase
I6G97_RS05030	COG3961	Belongs to the TPP enzyme family
I6G97_RS05035	COG2233	PERMEase
I6G97_RS05050	COG1309	transcriptional regulator
I6G97_RS05055	COG4232	protein-disulfide reductase activity
I6G97_RS05065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G97_RS05075	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6G97_RS05095	COG1556	Lactate utilization protein
I6G97_RS05100	COG1139	Iron-sulfur cluster binding protein
I6G97_RS05105	COG0247	lactate metabolic process
I6G97_RS05110	COG1620	l-lactate permease
I6G97_RS05115	COG1509	lysine 2,3-aminomutase activity
I6G97_RS05130	COG3385	transposase activity
I6G97_RS05140	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6G97_RS05145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G97_RS05150	COG1053	succinate dehydrogenase
I6G97_RS05160	COG3264	Mechanosensitive ion channel
I6G97_RS05160	COG1511	domain protein
I6G97_RS05165	COG0688	phosphatidylethanolamine metabolic process
I6G97_RS05200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6G97_RS05200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G97_RS05205	COG0802	atpase or kinase
I6G97_RS05220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G97_RS05225	COG1923	regulation of RNA biosynthetic process
I6G97_RS05230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G97_RS05235	COG0330	HflC and HflK could
I6G97_RS05240	COG0330	HflC and HflK could
I6G97_RS05250	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6G97_RS05265	COG1959	2 iron, 2 sulfur cluster binding
I6G97_RS05270	COG0557	exoribonuclease II activity
I6G97_RS05275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G97_RS05285	COG3650	response to hydrogen peroxide
I6G97_RS05290	COG1073	alpha beta
I6G97_RS05305	COG2965	DNA replication, synthesis of RNA primer
I6G97_RS05310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G97_RS05325	COG3061	Opacity-associated protein A
I6G97_RS05330	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G97_RS05350	COG1253	flavin adenine dinucleotide binding
I6G97_RS05355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G97_RS05360	COG0729	surface antigen
I6G97_RS05365	COG2911	Protein conserved in bacteria
I6G97_RS05370	COG2105	PFAM AIG2 family protein
I6G97_RS05375	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6G97_RS05380	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6G97_RS05385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G97_RS05400	COG3423	Transcriptional regulator
I6G97_RS05405	COG0142	geranyltranstransferase activity
I6G97_RS05410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G97_RS05420	COG0697	spore germination
I6G97_RS05425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6G97_RS05430	COG0642	Histidine kinase
I6G97_RS05435	COG0745	RESPONSE REGULATOR receiver
I6G97_RS05440	COG2027	D-alanyl-D-alanine carboxypeptidase
I6G97_RS05450	COG1534	Rna-binding protein
I6G97_RS05465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G97_RS05475	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G97_RS05495	COG0195	Participates in both transcription termination and antitermination
I6G97_RS05510	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G97_RS05530	COG0513	Belongs to the DEAD box helicase family
I6G97_RS05535	COG0814	amino acid
I6G97_RS05545	COG0826	peptidase U32
I6G97_RS05550	COG0826	peptidase U32
I6G97_RS05555	COG3154	lipid carrier protein
I6G97_RS05560	COG3153	acetyltransferase
I6G97_RS05565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G97_RS05570	COG2827	Endonuclease containing a URI domain
I6G97_RS05580	COG0702	epimerase
I6G97_RS05585	COG0602	queuosine metabolic process
I6G97_RS05600	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6G97_RS05605	COG4575	ribosome binding
I6G97_RS05615	COG0586	Pfam SNARE associated Golgi protein
I6G97_RS05625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G97_RS05635	COG2271	Major facilitator Superfamily
I6G97_RS05645	COG0246	Mannitol dehydrogenase
I6G97_RS05650	COG2721	sulfolactate sulfo-lyase activity
I6G97_RS05670	COG0697	spore germination
I6G97_RS05675	COG0673	inositol 2-dehydrogenase activity
I6G97_RS05680	COG1451	nucleotide metabolic process
I6G97_RS05690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G97_RS05695	COG0642	Histidine kinase
I6G97_RS05705	COG3111	PFAM Bacterial OB fold (BOF) protein
I6G97_RS05710	COG1882	Formate acetyltransferase
I6G97_RS05715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G97_RS05725	COG4974	Belongs to the 'phage' integrase family
I6G97_RS05760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G97_RS05800	COG4695	Portal protein
I6G97_RS05930	COG3663	DNA glycosylase
I6G97_RS05940	COG0358	DNA primase activity
I6G97_RS05960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G97_RS05965	COG1968	undecaprenyl-diphosphatase activity
I6G97_RS05975	COG4991	sh3 domain protein
I6G97_RS05980	COG0306	phosphate transporter
I6G97_RS05985	COG1392	Phosphate transport regulator
I6G97_RS05990	COG3025	triphosphatase activity
I6G97_RS05995	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6G97_RS06000	COG1560	Kdo2-lipid A biosynthetic process
I6G97_RS06010	COG0531	amino acid
I6G97_RS06015	COG2960	long-chain fatty acid transporting porin activity
I6G97_RS06030	COG3384	dioxygenase
I6G97_RS06055	COG2813	Specifically methylates the guanine in position
I6G97_RS06060	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6G97_RS06065	COG0456	acetyltransferase
I6G97_RS06075	COG4667	esterase of the alpha-beta hydrolase superfamily
I6G97_RS06080	COG0084	hydrolase, TatD family'
I6G97_RS06085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G97_RS06090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G97_RS06095	COG1328	CTP reductase activity
I6G97_RS06120	COG3783	Cytochrome b(562)
I6G97_RS06130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G97_RS06135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G97_RS06155	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G97_RS06160	COG1137	ATPase activity
I6G97_RS06165	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6G97_RS06170	COG3117	lipopolysaccharide transmembrane transporter activity
I6G97_RS06175	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G97_RS06180	COG0517	IMP dehydrogenase activity
I6G97_RS06180	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G97_RS06185	COG0530	calcium, potassium:sodium antiporter activity
I6G97_RS06190	COG1127	ABC transporter
I6G97_RS06195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G97_RS06200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G97_RS06205	COG2854	intermembrane phospholipid transfer
I6G97_RS06210	COG3113	response to antibiotic
I6G97_RS06215	COG5007	Belongs to the BolA IbaG family
I6G97_RS06220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G97_RS06225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G97_RS06230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G97_RS06235	COG3105	Protein conserved in bacteria
I6G97_RS06240	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G97_RS06255	COG0625	glutathione transferase activity
I6G97_RS06260	COG2969	positive regulation of protein catabolic process
I6G97_RS06265	COG2731	YhcH YjgK YiaL family protein
I6G97_RS06285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6G97_RS06300	COG0493	'glutamate synthase
I6G97_RS06305	COG0070	glutamate synthase
I6G97_RS06305	COG0069	glutamate synthase activity
I6G97_RS06305	COG0067	glutamate synthase
I6G97_RS06310	COG1242	4 iron, 4 sulfur cluster binding
I6G97_RS06315	COG0784	Response regulator, receiver
I6G97_RS06315	COG2198	Histidine kinase
I6G97_RS06315	COG5002	protein histidine kinase activity
I6G97_RS06320	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6G97_RS06325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G97_RS06330	COG2823	Periplasmic or secreted lipoprotein
I6G97_RS06340	COG0792	nuclease activity
I6G97_RS06350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6G97_RS06360	COG3726	membrane protein affecting hemolysin expression
I6G97_RS06365	COG0560	Phosphoserine phosphatase
I6G97_RS06380	COG0488	(ABC) transporter
I6G97_RS06390	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
I6G97_RS06395	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I6G97_RS06400	COG0406	alpha-ribazole phosphatase activity
I6G97_RS06405	COG2207	Transcriptional regulator
I6G97_RS06405	COG3708	Transcriptional regulator
I6G97_RS06410	COG3045	CreA protein
I6G97_RS06420	COG1720	tRNA m6t6A37 methyltransferase activity
I6G97_RS06445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G97_RS06470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G97_RS06475	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G97_RS06475	COG1042	CoA-binding domain protein
I6G97_RS06475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G97_RS06480	COG3148	PFAM DTW domain containing protein
I6G97_RS06485	COG3118	belongs to the thioredoxin family
I6G97_RS06490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G97_RS06495	COG0745	RESPONSE REGULATOR receiver
I6G97_RS06500	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6G97_RS06525	COG1115	amino acid carrier protein
I6G97_RS06535	COG1012	belongs to the aldehyde dehydrogenase family
I6G97_RS06545	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G97_RS06555	COG1584	GPR1 FUN34 yaaH family protein
I6G97_RS06575	COG0583	DNA-binding transcription factor activity
I6G97_RS06580	COG0268	Binds directly to 16S ribosomal RNA
I6G97_RS06585	COG0196	riboflavin kinase activity
I6G97_RS06600	COG1047	Peptidyl-prolyl cis-trans
I6G97_RS06610	COG1881	PFAM PEBP family protein
I6G97_RS06615	COG2080	2 iron, 2 sulfur cluster binding
I6G97_RS06620	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6G97_RS06625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G97_RS06635	COG0505	Belongs to the CarA family
I6G97_RS06640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G97_RS06645	COG2966	Psort location CytoplasmicMembrane, score
I6G97_RS06650	COG3610	response to peptide
I6G97_RS06655	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G97_RS06675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G97_RS06685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6G97_RS06690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6G97_RS06695	COG0564	pseudouridine synthase activity
I6G97_RS06700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G97_RS06705	COG0417	DNA replication proofreading
I6G97_RS06710	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6G97_RS06715	COG1178	ABC-type Fe3 transport system permease component
I6G97_RS06720	COG4143	(ABC) transporter
I6G97_RS06730	COG0471	metal ion transport
I6G97_RS06745	COG0473	3-isopropylmalate dehydrogenase activity
I6G97_RS06755	COG0583	DNA-binding transcription factor activity
I6G97_RS06760	COG1022	Amp-dependent synthetase and ligase
I6G97_RS06765	COG0028	Belongs to the TPP enzyme family
I6G97_RS06790	COG3116	cell division
I6G97_RS06795	COG0768	penicillin binding
I6G97_RS06800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G97_RS06805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G97_RS06820	COG0772	Belongs to the SEDS family
I6G97_RS06825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G97_RS06840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G97_RS06845	COG0849	cell division
I6G97_RS06850	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G97_RS06875	COG0494	nUDIX hydrolase
I6G97_RS06900	COG1459	type II secretion system
I6G97_RS06905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G97_RS06910	COG4969	Belongs to the N-Me-Phe pilin family
I6G97_RS06915	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G97_RS06920	COG3725	Membrane protein required for beta-lactamase induction
I6G97_RS06930	COG2186	Transcriptional regulator
I6G97_RS06935	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6G97_RS06940	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G97_RS06945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G97_RS06960	COG2979	Protein of unknown function (DUF533)
I6G97_RS06985	COG0288	reversible hydration of carbon dioxide
I6G97_RS06990	COG0745	RESPONSE REGULATOR receiver
I6G97_RS06995	COG1131	(ABC) transporter
I6G97_RS07000	COG0842	Transport permease protein
I6G97_RS07005	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G97_RS07010	COG1349	DNA-binding transcription factor activity
I6G97_RS07015	COG2222	sugar isomerase
I6G97_RS07020	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G97_RS07025	COG3715	PTS system
I6G97_RS07030	COG3716	PTS system mannose fructose sorbose family IID component
I6G97_RS07045	COG0726	polysaccharide deacetylase
I6G97_RS07065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G97_RS07070	COG0617	tRNA 3'-terminal CCA addition
I6G97_RS07090	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6G97_RS07095	COG1643	Atp-dependent helicase
I6G97_RS07100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G97_RS07105	COG3385	transposase activity
I6G97_RS07110	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G97_RS07115	COG3416	Protein conserved in bacteria
I6G97_RS07120	COG2234	aminopeptidase activity
I6G97_RS07135	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6G97_RS07150	COG4795	General secretion pathway protein
I6G97_RS07165	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6G97_RS07175	COG1074	ATP-dependent DNA helicase activity
I6G97_RS07180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G97_RS07190	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G97_RS07210	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6G97_RS07215	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G97_RS07220	COG2166	iron-sulfur cluster assembly
I6G97_RS07225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G97_RS07235	COG0583	DNA-binding transcription factor activity
I6G97_RS07240	COG2363	Small membrane protein
I6G97_RS07255	COG1611	Belongs to the LOG family
I6G97_RS07270	COG3098	single-species biofilm formation
I6G97_RS07295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6G97_RS07305	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G97_RS07315	COG0528	UMP kinase activity
I6G97_RS07330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G97_RS07335	COG0575	Belongs to the CDS family
I6G97_RS07340	COG0750	zinc metalloprotease
I6G97_RS07350	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6G97_RS07355	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G97_RS07360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G97_RS07365	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G97_RS07370	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G97_RS07390	COG0346	lactoylglutathione lyase activity
I6G97_RS07395	COG3710	Transcriptional regulator
I6G97_RS07400	COG0531	amino acid
I6G97_RS07405	COG1982	Orn Lys Arg decarboxylase major
I6G97_RS07410	COG3104	oligopeptide transport
I6G97_RS07425	COG4568	rho-dependent transcription termination
I6G97_RS07445	COG3015	lipoprotein NlpE involved in copper resistance
I6G97_RS07450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G97_RS07455	COG1737	Transcriptional regulator
I6G97_RS07460	COG0560	Phosphoserine phosphatase
I6G97_RS07465	COG1454	alcohol dehydrogenase
I6G97_RS07470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G97_RS07485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G97_RS07485	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G97_RS07490	COG2205	protein histidine kinase activity
I6G97_RS07500	COG2204	response regulator
I6G97_RS07505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G97_RS07505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6G97_RS07510	COG0347	Belongs to the P(II) protein family
I6G97_RS07520	COG0121	glutamine amidotransferase
I6G97_RS07525	COG3034	peptidoglycan biosynthetic process
I6G97_RS07530	COG1477	protein flavinylation
I6G97_RS07535	COG0004	ammonium transporteR
I6G97_RS07550	COG0531	amino acid
I6G97_RS07555	COG0076	glutamate decarboxylase activity
I6G97_RS07565	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G97_RS07570	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G97_RS07575	COG3040	lipid binding
I6G97_RS07580	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G97_RS07590	COG1073	alpha beta
I6G97_RS07600	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G97_RS07610	COG2130	NADP-dependent
I6G97_RS07630	COG1278	Cold shock
I6G97_RS07675	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
I6G97_RS07740	COG0583	DNA-binding transcription factor activity
I6G97_RS07760	COG1882	Formate acetyltransferase
I6G97_RS07795	COG1879	ABC-type sugar transport system periplasmic component
I6G97_RS07820	COG1070	Carbohydrate kinase
I6G97_RS07850	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6G97_RS07860	COG0778	Nitroreductase
I6G97_RS07870	COG0583	DNA-binding transcription factor activity
I6G97_RS07875	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G97_RS07890	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G97_RS07895	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6G97_RS07900	COG3842	ATPase activity
I6G97_RS07915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G97_RS07920	COG1737	Transcriptional regulator
I6G97_RS07925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G97_RS07945	COG1011	Hydrolase
I6G97_RS07965	COG0531	amino acid
I6G97_RS07970	COG0443	Heat shock 70 kDa protein
I6G97_RS07975	COG5002	protein histidine kinase activity
I6G97_RS07975	COG5001	Diguanylate cyclase
I6G97_RS07975	COG3447	MASE1 domain protein
I6G97_RS07990	COG2200	EAL domain
I6G97_RS08020	COG0668	transmembrane transport
I6G97_RS08025	COG0366	Alpha amylase catalytic
I6G97_RS08030	COG0450	alkyl hydroperoxide reductase
I6G97_RS08035	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6G97_RS08050	COG1862	Preprotein translocase
I6G97_RS08055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G97_RS08060	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G97_RS08065	COG2204	response regulator
I6G97_RS08070	COG2223	nitrite transmembrane transporter activity
I6G97_RS08100	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G97_RS08100	COG1902	pentaerythritol trinitrate reductase activity
I6G97_RS08105	COG0531	amino acid
I6G97_RS08110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G97_RS08120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G97_RS08120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G97_RS08140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G97_RS08150	COG1609	Transcriptional regulator
I6G97_RS08155	COG0477	Major facilitator Superfamily
I6G97_RS08165	COG0142	geranyltranstransferase activity
I6G97_RS08180	COG0693	protein deglycase activity
I6G97_RS08185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G97_RS08195	COG2814	Major facilitator Superfamily
I6G97_RS08200	COG2223	nitrite transmembrane transporter activity
I6G97_RS08205	COG3056	Lipoprotein
I6G97_RS08210	COG0271	Belongs to the BolA IbaG family
I6G97_RS08230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G97_RS08235	COG0776	regulation of translation
I6G97_RS08240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G97_RS08245	COG1555	photosystem II stabilization
I6G97_RS08265	COG1522	sequence-specific DNA binding
I6G97_RS08270	COG0347	Belongs to the P(II) protein family
I6G97_RS08275	COG0004	ammonium transporteR
I6G97_RS08280	COG1946	Acyl-CoA thioesterase
I6G97_RS08285	COG3695	enzyme binding
I6G97_RS08305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G97_RS08310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G97_RS08315	COG1309	transcriptional regulator
I6G97_RS08320	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6G97_RS08325	COG1196	nuclear chromosome segregation
I6G97_RS08325	COG3264	Mechanosensitive ion channel
I6G97_RS08335	COG2261	transglycosylase associated protein
I6G97_RS08345	COG2832	Protein of unknown function (DUF454)
I6G97_RS08370	COG0326	Molecular chaperone. Has ATPase activity
I6G97_RS08385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G97_RS08395	COG3121	Chaperone
I6G97_RS08400	COG3188	usher protein
I6G97_RS08410	COG0737	Belongs to the 5'-nucleotidase family
I6G97_RS08420	COG2610	gluconate transmembrane transporter activity
I6G97_RS08425	COG2186	Transcriptional regulator
I6G97_RS08430	COG3735	TraB family
I6G97_RS08435	COG2217	Heavy metal translocating P-type atpase
I6G97_RS08445	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6G97_RS08450	COG0330	HflC and HflK could
I6G97_RS08460	COG0602	queuosine metabolic process
I6G97_RS08470	COG2814	Major facilitator Superfamily
I6G97_RS08475	COG0720	synthase
I6G97_RS08480	COG0277	FAD linked oxidase domain protein
I6G97_RS08485	COG0640	Transcriptional regulator
I6G97_RS08495	COG0583	DNA-binding transcription factor activity
I6G97_RS08515	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G97_RS08520	COG2351	hydroxyisourate hydrolase activity
I6G97_RS08525	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6G97_RS08545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G97_RS08550	COG0583	DNA-binding transcription factor activity
I6G97_RS08555	COG0826	peptidase U32
I6G97_RS08560	COG3422	double-strand break repair
I6G97_RS08565	COG0745	RESPONSE REGULATOR receiver
I6G97_RS08570	COG2205	protein histidine kinase activity
I6G97_RS08590	COG1940	carbohydrate kinase activity
I6G97_RS08605	COG0419	ATPase involved in DNA repair
I6G97_RS08610	COG0420	3'-5' exonuclease activity
I6G97_RS08615	COG0745	RESPONSE REGULATOR receiver
I6G97_RS08620	COG5002	protein histidine kinase activity
I6G97_RS08635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G97_RS08640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G97_RS08655	COG2233	PERMEase
I6G97_RS08665	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G97_RS08670	COG1393	Belongs to the ArsC family
I6G97_RS08675	COG4783	chaperone-mediated protein folding
I6G97_RS08680	COG0628	permease
I6G97_RS08685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G97_RS08690	COG2716	regulation of RNA biosynthetic process
I6G97_RS08700	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6G97_RS08715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G97_RS08725	COG1444	tRNA N-acetyltransferase activity
I6G97_RS08730	COG0400	carboxylic ester hydrolase activity
I6G97_RS08740	COG1876	peptidase activity
I6G97_RS08745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G97_RS08750	COG1393	Belongs to the ArsC family
I6G97_RS08755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G97_RS08770	COG2197	response regulator
I6G97_RS08775	COG3850	Histidine kinase
I6G97_RS08780	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G97_RS08780	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G97_RS08785	COG3062	negative regulation of establishment of protein localization
I6G97_RS08795	COG0437	4 iron, 4 sulfur cluster binding
I6G97_RS08800	COG0348	domain, Protein
I6G97_RS08805	COG3043	anaerobic respiration
I6G97_RS08810	COG3005	denitrification pathway
I6G97_RS08815	COG0494	nUDIX hydrolase
I6G97_RS08820	COG0280	phosphate acetyltransferase
I6G97_RS08820	COG0281	malic enzyme
I6G97_RS08830	COG1671	Belongs to the UPF0178 family
I6G97_RS08840	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G97_RS08845	COG0456	acetyltransferase
I6G97_RS08855	COG2837	iron assimilation
I6G97_RS08860	COG2190	(PTS) system
I6G97_RS08865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G97_RS08870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G97_RS08885	COG3115	cell septum assembly
I6G97_RS08890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G97_RS08895	COG3530	Putative quorum-sensing-regulated virulence factor
I6G97_RS08940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G97_RS08970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G97_RS08975	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G97_RS09000	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I6G97_RS09005	COG2943	transferase activity, transferring hexosyl groups
I6G97_RS09015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G97_RS09020	COG0303	'Molybdopterin
I6G97_RS09030	COG2311	Membrane
I6G97_RS09035	COG2199	diguanylate cyclase activity
I6G97_RS09035	COG2200	EAL domain
I6G97_RS09040	COG2949	membrane
I6G97_RS09055	COG1346	cytolysis
I6G97_RS09060	COG1380	Effector of murein hydrolase LrgA
I6G97_RS09065	COG2962	Rard protein
I6G97_RS09070	COG2925	Exonuclease
I6G97_RS09075	COG1289	transmembrane transporter activity
I6G97_RS09085	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6G97_RS09095	COG2855	membrane
I6G97_RS09110	COG0583	DNA-binding transcription factor activity
I6G97_RS09115	COG0833	amino acid
I6G97_RS09120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G97_RS09120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G97_RS09125	COG0489	protein tyrosine kinase activity
I6G97_RS09130	COG0572	uridine kinase
I6G97_RS09135	COG0697	spore germination
I6G97_RS09145	COG2982	Protein involved in outer membrane biogenesis
I6G97_RS09150	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G97_RS09155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6G97_RS09160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6G97_RS09185	COG0438	transferase activity, transferring glycosyl groups
I6G97_RS09195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G97_RS09210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6G97_RS09250	COG0814	amino acid
I6G97_RS09255	COG0583	DNA-binding transcription factor activity
I6G97_RS09270	COG2194	sulfuric ester hydrolase activity
I6G97_RS09275	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G97_RS09280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G97_RS09295	COG2747	anti-sigma28 factor FlgM
I6G97_RS09305	COG1815	bacterial-type flagellum-dependent cell motility
I6G97_RS09310	COG1558	bacterial-type flagellum-dependent cell motility
I6G97_RS09320	COG1749	Flagellar hook protein flgE
I6G97_RS09330	COG4786	Flagellar basal body rod
I6G97_RS09335	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6G97_RS09345	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6G97_RS09345	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G97_RS09360	COG3059	membrane
I6G97_RS09370	COG1448	Aminotransferase
I6G97_RS09390	COG0308	aminopeptidase N
I6G97_RS09400	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G97_RS09420	COG1122	ATPase activity
I6G97_RS09425	COG1122	ATPase activity
I6G97_RS09430	COG2364	Membrane
I6G97_RS09465	COG0116	Belongs to the methyltransferase superfamily
I6G97_RS09465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G97_RS09470	COG0488	(ABC) transporter
I6G97_RS09475	COG2995	paraquat-inducible protein a
I6G97_RS09480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G97_RS09480	COG3008	intermembrane lipid transfer
I6G97_RS09485	COG3009	Protein conserved in bacteria
I6G97_RS09490	COG3130	regulation of translation
I6G97_RS09500	COG1067	ATP-dependent peptidase activity
I6G97_RS09505	COG3120	sequence-specific DNA binding
I6G97_RS09525	COG1289	transmembrane transporter activity
I6G97_RS09530	COG3304	Inner membrane component domain
I6G97_RS09535	COG0210	DNA helicase
I6G97_RS09550	COG1832	CoA-binding protein
I6G97_RS09555	COG3785	DNA binding
I6G97_RS09560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G97_RS09565	COG1254	Belongs to the acylphosphatase family
I6G97_RS09570	COG2920	part of a sulfur-relay system
I6G97_RS09575	COG0670	Belongs to the BI1 family
I6G97_RS09585	COG2271	Major facilitator Superfamily
I6G97_RS09615	COG2076	Multidrug Resistance protein
I6G97_RS09620	COG2076	Multidrug Resistance protein
I6G97_RS09640	COG2842	Transposition protein
I6G97_RS09760	COG4383	Mu-like prophage protein gp29
I6G97_RS09765	COG2369	cell adhesion
I6G97_RS09785	COG4397	Mu-like prophage major head subunit gpT
I6G97_RS09795	COG4387	Mu-like prophage protein GP36
I6G97_RS09860	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G97_RS09860	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G97_RS09865	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6G97_RS09890	COG0582	viral genome integration into host DNA
I6G97_RS09930	COG3723	Recombinational DNA repair protein, rece pathway
I6G97_RS09935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G97_RS09990	COG0305	Participates in initiation and elongation during chromosome replication
I6G97_RS10015	COG3646	Phage regulatory protein
I6G97_RS10015	COG3645	SOS response
I6G97_RS10060	COG3772	lysozyme
I6G97_RS10090	COG1802	Transcriptional regulator
I6G97_RS10090	COG4626	Terminase
I6G97_RS10100	COG4695	Portal protein
I6G97_RS10145	COG4386	tail sheath protein
I6G97_RS10170	COG4228	DNA circulation
I6G97_RS10190	COG3299	homolog of phage Mu protein gp47
I6G97_RS10195	COG3778	Protein conserved in bacteria
I6G97_RS10200	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G97_RS10285	COG2207	Transcriptional regulator
I6G97_RS10290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G97_RS10295	COG1335	isochorismatase
I6G97_RS10300	COG2194	sulfuric ester hydrolase activity
I6G97_RS10305	COG0768	penicillin binding
I6G97_RS10315	COG0589	response to stress
I6G97_RS10320	COG1979	alcohol dehydrogenase
I6G97_RS10345	COG0643	Histidine kinase
I6G97_RS10345	COG2198	Histidine kinase
I6G97_RS10350	COG0835	chemotaxis
I6G97_RS10355	COG0840	transmembrane signaling receptor activity
I6G97_RS10360	COG0840	transmembrane signaling receptor activity
I6G97_RS10365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G97_RS10370	COG2201	protein-glutamate methylesterase activity
I6G97_RS10375	COG0745	RESPONSE REGULATOR receiver
I6G97_RS10380	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6G97_RS10385	COG0387	Pfam Sodium calcium exchanger
I6G97_RS10390	COG0586	Pfam SNARE associated Golgi protein
I6G97_RS10395	COG5645	(Lipo)protein
I6G97_RS10400	COG1473	amidohydrolase
I6G97_RS10410	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G97_RS10415	COG3493	citrate carrier protein
I6G97_RS10420	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G97_RS10425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G97_RS10430	COG0583	DNA-binding transcription factor activity
I6G97_RS10435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G97_RS10440	COG3122	Protein conserved in bacteria
I6G97_RS10445	COG0513	Belongs to the DEAD box helicase family
I6G97_RS10450	COG2188	Transcriptional regulator
I6G97_RS10455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G97_RS10455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G97_RS10455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G97_RS10460	COG0383	alpha-mannosidase activity
I6G97_RS10470	COG0012	GTP binding
I6G97_RS10485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G97_RS10495	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6G97_RS10510	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G97_RS10530	COG0659	secondary active sulfate transmembrane transporter activity
I6G97_RS10555	COG4134	Bacterial extracellular solute-binding protein
I6G97_RS10565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G97_RS10580	COG3381	protein complex oligomerization
I6G97_RS10595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G97_RS10600	COG3132	Protein of unknown function, DUF480
I6G97_RS10605	COG0728	peptidoglycan biosynthetic process
I6G97_RS10615	COG3102	Protein conserved in bacteria
I6G97_RS10620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G97_RS10640	COG1113	amino acid transport
I6G97_RS10645	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6G97_RS10650	COG1801	Protein of unknown function DUF72
I6G97_RS10665	COG0494	nUDIX hydrolase
I6G97_RS10690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G97_RS10695	COG1121	(ABC) transporter
I6G97_RS10700	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6G97_RS10705	COG0739	heme binding
I6G97_RS10710	COG1560	Kdo2-lipid A biosynthetic process
I6G97_RS10715	COG0730	response to heat
I6G97_RS10720	COG0469	pyruvate kinase activity
I6G97_RS10725	COG1737	Transcriptional regulator
I6G97_RS10730	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G97_RS10740	COG0129	dihydroxy-acid dehydratase activity
I6G97_RS10745	COG0800	Aldolase
I6G97_RS10750	COG2076	Multidrug Resistance protein
I6G97_RS10755	COG2076	Multidrug Resistance protein
I6G97_RS10760	COG0251	oxidation-reduction process
I6G97_RS10765	COG1199	ATP-dependent helicase activity
I6G97_RS10775	COG3065	identical protein binding
I6G97_RS10780	COG0318	PFAM AMP-dependent synthetase and ligase
I6G97_RS10785	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6G97_RS10795	COG2894	cell division
I6G97_RS10810	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G97_RS10820	COG0589	response to stress
I6G97_RS10825	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6G97_RS10845	COG2719	SpoVR family
I6G97_RS10860	COG1362	aminopeptidase activity
I6G97_RS10865	COG3104	oligopeptide transport
I6G97_RS10880	COG2766	serine protein kinase
I6G97_RS10885	COG3713	MltA-interacting MipA family protein
I6G97_RS10900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G97_RS10905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G97_RS10910	COG3139	Protein of unknown function (DUF1315)
I6G97_RS10915	COG1335	isochorismatase
I6G97_RS10920	COG0252	asparaginase activity
I6G97_RS10925	COG0616	signal peptide processing
I6G97_RS10930	COG0778	Nitroreductase
I6G97_RS10940	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6G97_RS10945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G97_RS10955	COG0494	nUDIX hydrolase
I6G97_RS10960	COG0708	Exodeoxyribonuclease III
I6G97_RS10995	COG0788	formyltetrahydrofolate deformylase activity
I6G97_RS11000	COG3012	SEC-C Motif Domain Protein
I6G97_RS11005	COG0745	RESPONSE REGULATOR receiver
I6G97_RS11010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G97_RS11015	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6G97_RS11025	COG1454	alcohol dehydrogenase
I6G97_RS11025	COG1012	belongs to the aldehyde dehydrogenase family
I6G97_RS11030	COG2095	MarC family integral membrane protein
I6G97_RS11045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G97_RS11060	COG3099	Belongs to the UPF0263 family
I6G97_RS11075	COG0783	Belongs to the Dps family
I6G97_RS11080	COG2350	Protein conserved in bacteria
I6G97_RS11090	COG1607	acyl-coa hydrolase
I6G97_RS11105	COG4145	pantothenate transmembrane transporter activity
I6G97_RS11115	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6G97_RS11125	COG2823	Periplasmic or secreted lipoprotein
I6G97_RS11140	COG0134	indole-3-glycerol-phosphate synthase activity
I6G97_RS11140	COG0135	phosphoribosylanthranilate isomerase activity
I6G97_RS11145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G97_RS11145	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G97_RS11150	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G97_RS11160	COG0613	PHP domain protein
I6G97_RS11165	COG0009	L-threonylcarbamoyladenylate synthase
I6G97_RS11175	COG0765	amino acid transport
I6G97_RS11180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G97_RS11185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G97_RS11190	COG2207	Transcriptional regulator
I6G97_RS11205	COG1187	pseudouridine synthase activity
I6G97_RS11215	COG0406	alpha-ribazole phosphatase activity
I6G97_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
I6G97_RS11230	COG0616	signal peptide processing
I6G97_RS11260	COG2226	methyltransferase
I6G97_RS11270	COG3716	PTS system mannose fructose sorbose family IID component
I6G97_RS11275	COG3715	PTS system
I6G97_RS11280	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G97_RS11280	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G97_RS11285	COG1253	flavin adenine dinucleotide binding
I6G97_RS11290	COG2200	EAL domain
I6G97_RS11325	COG0307	riboflavin synthase, alpha
I6G97_RS11330	COG2814	Major facilitator Superfamily
I6G97_RS11340	COG1823	symporter activity
I6G97_RS11345	COG1988	membrane-bound metal-dependent
I6G97_RS11350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G97_RS11360	COG3001	Fructosamine kinase
I6G97_RS11375	COG0814	amino acid
I6G97_RS11380	COG1124	(ABC) transporter
I6G97_RS11390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G97_RS11395	COG0601	transmembrane transport
I6G97_RS11405	COG3152	Membrane
I6G97_RS11435	COG1794	racemase activity, acting on amino acids and derivatives
I6G97_RS11450	COG1028	Short-chain dehydrogenase reductase Sdr
I6G97_RS11460	COG3678	ATP-independent chaperone mediated protein folding
I6G97_RS11470	COG3210	domain, Protein
I6G97_RS11550	COG0537	adenosine 5'-monophosphoramidase activity
I6G97_RS11585	COG0531	amino acid
I6G97_RS11590	COG1177	transmembrane transport
I6G97_RS11610	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G97_RS11615	COG0814	amino acid
I6G97_RS11625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G97_RS11635	COG0668	transmembrane transport
I6G97_RS11640	COG4172	Belongs to the ABC transporter superfamily
I6G97_RS11650	COG4171	peptide transport system, permease
I6G97_RS11665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6G97_RS11670	COG1842	Phage shock protein A
I6G97_RS11680	COG1983	PspC domain protein
I6G97_RS11685	COG3106	COG3106 Predicted ATPase
I6G97_RS11690	COG3768	UPF0283 membrane protein
I6G97_RS11695	COG2897	thiosulfate sulfurtransferase activity
I6G97_RS11705	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G97_RS11725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G97_RS11730	COG1492	cobalamin metabolic process
I6G97_RS11740	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6G97_RS11745	COG1115	amino acid carrier protein
I6G97_RS11770	COG1760	l-serine dehydratase
I6G97_RS11795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G97_RS11805	COG3141	response to X-ray
I6G97_RS11815	COG2200	EAL domain
I6G97_RS11820	COG1770	oligopeptidase
I6G97_RS11825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G97_RS11830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G97_RS11840	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G97_RS11845	COG0783	Belongs to the Dps family
I6G97_RS11860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G97_RS11895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G97_RS11895	COG0072	phenylalanine-tRNA ligase activity
I6G97_RS11910	COG4139	cobalamin transport
I6G97_RS11915	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6G97_RS11920	COG0791	NLP P60 protein
I6G97_RS11925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G97_RS11935	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6G97_RS11940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G97_RS11945	COG4558	Periplasmic binding protein
I6G97_RS11950	COG3720	iron ion transport
I6G97_RS11955	COG4771	TonB-dependent receptor
I6G97_RS11965	COG0702	epimerase
I6G97_RS11980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G97_RS11985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G97_RS11990	COG0574	Belongs to the PEP-utilizing enzyme family
I6G97_RS11990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G97_RS11995	COG0628	permease
I6G97_RS12000	COG0277	FAD linked oxidase domain protein
I6G97_RS12000	COG0247	lactate metabolic process
I6G97_RS12005	COG2050	protein possibly involved in aromatic compounds catabolism
I6G97_RS12025	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G97_RS12025	COG0493	'glutamate synthase
I6G97_RS12030	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6G97_RS12030	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6G97_RS12030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G97_RS12030	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6G97_RS12040	COG1285	pathogenesis
I6G97_RS12045	COG3042	response to heat
I6G97_RS12050	COG3187	Heat shock protein
I6G97_RS12060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G97_RS12065	COG2911	Protein conserved in bacteria
I6G97_RS12075	COG3784	Protein of unknown function (DUF1318)
I6G97_RS12080	COG1643	Atp-dependent helicase
I6G97_RS12085	COG3591	Belongs to the peptidase S1B family
I6G97_RS12100	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6G97_RS12105	COG2205	protein histidine kinase activity
I6G97_RS12110	COG0745	RESPONSE REGULATOR receiver
I6G97_RS12115	COG1028	Short-chain dehydrogenase reductase Sdr
I6G97_RS12125	COG0531	amino acid
I6G97_RS12135	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6G97_RS12140	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6G97_RS12145	COG0589	response to stress
I6G97_RS12150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G97_RS12155	COG0826	peptidase U32
I6G97_RS12175	COG3691	Protein conserved in bacteria
I6G97_RS12185	COG3065	identical protein binding
I6G97_RS12195	COG0589	response to stress
I6G97_RS12200	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6G97_RS12210	COG4221	oxidoreductase activity
I6G97_RS12225	COG2814	Major facilitator Superfamily
I6G97_RS12230	COG4580	involved in the transport of maltose and maltodextrins
I6G97_RS12240	COG1858	cytochrome C peroxidase
I6G97_RS12245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6G97_RS12250	COG1940	carbohydrate kinase activity
I6G97_RS12255	COG0583	DNA-binding transcription factor activity
I6G97_RS12260	COG2814	Major facilitator Superfamily
I6G97_RS12270	COG1482	cell wall glycoprotein biosynthetic process
I6G97_RS12275	COG5339	Protein conserved in bacteria
I6G97_RS12285	COG0385	Bile acid
I6G97_RS12295	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6G97_RS12320	COG4658	electron transport chain
I6G97_RS12335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G97_RS12345	COG0625	glutathione transferase activity
I6G97_RS12365	COG3895	Periplasmic Protein
I6G97_RS12375	COG3133	Outer membrane lipoprotein
I6G97_RS12385	COG0346	lactoylglutathione lyase activity
I6G97_RS12390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G97_RS12395	COG2056	Na+-H+ antiporter family
I6G97_RS12400	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6G97_RS12405	COG0791	NLP P60 protein
I6G97_RS12425	COG4135	transport system, permease component
I6G97_RS12430	COG4136	ATPase activity
I6G97_RS12435	COG0583	DNA-binding transcription factor activity
I6G97_RS12440	COG2814	Major facilitator Superfamily
I6G97_RS12445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G97_RS12470	COG0745	RESPONSE REGULATOR receiver
I6G97_RS12475	COG5002	protein histidine kinase activity
I6G97_RS12485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G97_RS12490	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G97_RS12490	COG0506	proline dehydrogenase activity
I6G97_RS12490	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G97_RS12495	COG0501	Belongs to the peptidase M48B family
I6G97_RS12500	COG0366	Alpha amylase catalytic
I6G97_RS12505	COG3718	enzyme involved in inositol metabolism
I6G97_RS12515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G97_RS12525	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G97_RS12540	COG0673	inositol 2-dehydrogenase activity
I6G97_RS12545	COG3962	Belongs to the TPP enzyme family
I6G97_RS12570	COG1956	GAF domain-containing protein
I6G97_RS12575	COG2995	paraquat-inducible protein a
I6G97_RS12580	COG3008	intermembrane lipid transfer
I6G97_RS12605	COG4566	intracellular signal transduction
I6G97_RS12610	COG1342	Belongs to the UPF0251 family
I6G97_RS12630	COG2200	EAL domain
I6G97_RS12630	COG2771	luxR family
I6G97_RS12655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G97_RS12660	COG0471	metal ion transport
I6G97_RS12665	COG2828	Protein conserved in bacteria
I6G97_RS12670	COG0583	DNA-binding transcription factor activity
I6G97_RS12730	COG2885	chlorophyll binding
I6G97_RS12735	COG2199	diguanylate cyclase activity
I6G97_RS12750	COG0589	response to stress
I6G97_RS12775	COG2271	Major facilitator Superfamily
I6G97_RS12785	COG1486	melibiose metabolic process
I6G97_RS12790	COG2169	Transcriptional regulator
I6G97_RS12795	COG4783	chaperone-mediated protein folding
I6G97_RS12805	COG1349	DNA-binding transcription factor activity
I6G97_RS12810	COG2084	Dehydrogenase
I6G97_RS12820	COG0235	Class ii aldolase
I6G97_RS12825	COG3622	Belongs to the hyi family
I6G97_RS12830	COG2610	gluconate transmembrane transporter activity
I6G97_RS12855	COG0626	cystathionine gamma-synthase activity
I6G97_RS12860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G97_RS12865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G97_RS12870	COG1120	ATPase activity
I6G97_RS12905	COG3250	beta-galactosidase activity
I6G97_RS12915	COG2246	polysaccharide biosynthetic process
I6G97_RS12930	COG0456	acetyltransferase
I6G97_RS12955	COG2188	Transcriptional regulator
I6G97_RS12970	COG2731	YhcH YjgK YiaL family protein
I6G97_RS13000	COG0747	negative chemotaxis
I6G97_RS13005	COG0601	transmembrane transport
I6G97_RS13010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G97_RS13025	COG0114	fumarate hydratase activity
I6G97_RS13030	COG1442	glycosyl transferase family 8
I6G97_RS13030	COG1216	Glycosyl transferase, family 2
I6G97_RS13035	COG1335	isochorismatase
I6G97_RS13045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G97_RS13050	COG1304	FMN binding
I6G97_RS13055	COG0549	Belongs to the carbamate kinase family
I6G97_RS13065	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6G97_RS13070	COG0583	DNA-binding transcription factor activity
I6G97_RS13080	COG2610	gluconate transmembrane transporter activity
I6G97_RS13085	COG0583	DNA-binding transcription factor activity
I6G97_RS13090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G97_RS13095	COG0254	rRNA binding
I6G97_RS13105	COG0738	Major facilitator superfamily
I6G97_RS13115	COG1349	DNA-binding transcription factor activity
I6G97_RS13220	COG3829	transcription factor binding
I6G97_RS13220	COG3290	protein histidine kinase activity
I6G97_RS13225	COG0697	spore germination
I6G97_RS13230	COG2199	diguanylate cyclase activity
I6G97_RS13235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G97_RS13240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G97_RS13245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6G97_RS13250	COG0066	3-isopropylmalate dehydratase activity
I6G97_RS13260	COG1881	PFAM PEBP family protein
I6G97_RS13265	COG3477	response to acidic pH
I6G97_RS13275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G97_RS13285	COG0679	Auxin Efflux Carrier
I6G97_RS13355	COG0366	Alpha amylase catalytic
I6G97_RS13360	COG1263	PTS System
I6G97_RS13360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G97_RS13365	COG1609	Transcriptional regulator
I6G97_RS13370	COG0697	spore germination
I6G97_RS13375	COG2207	Transcriptional regulator
I6G97_RS13380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G97_RS13385	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G97_RS13390	COG1882	Formate acetyltransferase
I6G97_RS13395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G97_RS13400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G97_RS13405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G97_RS13405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G97_RS13405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G97_RS13425	COG1538	Outer membrane efflux protein
I6G97_RS13435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G97_RS13455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G97_RS13465	COG2197	response regulator
I6G97_RS13490	COG3646	Phage regulatory protein
I6G97_RS13510	COG0538	isocitrate dehydrogenase activity
I6G97_RS13540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G97_RS13545	COG2188	Transcriptional regulator
I6G97_RS13550	COG1397	ADP-ribosylglycohydrolase
I6G97_RS13555	COG0745	RESPONSE REGULATOR receiver
I6G97_RS13560	COG2205	protein histidine kinase activity
I6G97_RS13565	COG2850	peptidyl-arginine hydroxylation
I6G97_RS13580	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G97_RS13585	COG1136	(ABC) transporter
I6G97_RS13590	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G97_RS13595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G97_RS13600	COG3134	Outer membrane lipoprotein
I6G97_RS13610	COG1252	NADH dehydrogenase
I6G97_RS13615	COG1349	DNA-binding transcription factor activity
I6G97_RS13645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G97_RS13655	COG0586	Pfam SNARE associated Golgi protein
I6G97_RS13665	COG0023	Translation Initiation Factor
I6G97_RS13675	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6G97_RS13680	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6G97_RS13700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G97_RS13700	COG1263	PTS System
I6G97_RS13705	COG0084	hydrolase, TatD family'
I6G97_RS13710	COG0470	DNA polymerase III
I6G97_RS13720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G97_RS13725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G97_RS13730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G97_RS13745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G97_RS13765	COG1399	metal-binding, possibly nucleic acid-binding protein
I6G97_RS13775	COG0564	pseudouridine synthase activity
I6G97_RS13785	COG1530	ribonuclease E activity
I6G97_RS13795	COG4619	ABC transporter
I6G97_RS13800	COG0390	transport system, permease component
I6G97_RS13805	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G97_RS13805	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G97_RS13815	COG2610	gluconate transmembrane transporter activity
I6G97_RS13820	COG1028	Short-chain dehydrogenase reductase Sdr
I6G97_RS13825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G97_RS13830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G97_RS13835	COG0183	Belongs to the thiolase family
I6G97_RS13845	COG1126	abc transporter atp-binding protein
I6G97_RS13895	COG1766	The M ring may be actively involved in energy transduction
I6G97_RS13900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G97_RS13920	COG3144	bacterial-type flagellum assembly
I6G97_RS13925	COG1580	Controls the rotational direction of flagella during chemotaxis
I6G97_RS13960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G97_RS13965	COG3108	Peptidase M15
I6G97_RS13970	COG2989	Protein conserved in bacteria
I6G97_RS13990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G97_RS13995	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6G97_RS14010	COG2233	PERMEase
I6G97_RS14015	COG3173	Aminoglycoside phosphotransferase
I6G97_RS14050	COG0658	competence protein
I6G97_RS14050	COG2333	competence protein COMEC
I6G97_RS14060	COG0539	negative regulation of cytoplasmic translation
I6G97_RS14080	COG0252	asparaginase activity
I6G97_RS14085	COG1944	ATP diphosphatase activity
I6G97_RS14090	COG2116	formate transmembrane transporter activity
I6G97_RS14095	COG1882	Formate acetyltransferase
I6G97_RS14100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G97_RS14105	COG1309	transcriptional regulator
I6G97_RS14130	COG2814	Major facilitator Superfamily
I6G97_RS14135	COG2221	Nitrite and sulphite reductase 4Fe-4S
I6G97_RS14135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G97_RS14140	COG3381	protein complex oligomerization
I6G97_RS14145	COG3302	dmso reductase anchor subunit
I6G97_RS14150	COG0437	4 iron, 4 sulfur cluster binding
I6G97_RS14155	COG0243	molybdopterin cofactor binding
I6G97_RS14165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G97_RS14175	COG1674	ftsk spoiiie
I6G97_RS14175	COG3107	peptidoglycan biosynthetic process
I6G97_RS14180	COG1522	sequence-specific DNA binding
I6G97_RS14185	COG0492	ferredoxin-NADP+ reductase activity
I6G97_RS14190	COG4988	ABC transporter
I6G97_RS14195	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6G97_RS14205	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G97_RS14210	COG0542	response to heat
I6G97_RS14220	COG1278	Cold shock
I6G97_RS14225	COG2990	Protein conserved in bacteria
I6G97_RS14230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6G97_RS14235	COG3593	DNA synthesis involved in DNA repair
I6G97_RS14240	COG2431	L-lysine efflux transmembrane transporter activity
I6G97_RS14250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G97_RS14270	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6G97_RS14275	COG0702	epimerase
I6G97_RS14280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G97_RS14285	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G97_RS14290	COG2197	response regulator
I6G97_RS14300	COG3121	Chaperone
I6G97_RS14305	COG3188	usher protein
I6G97_RS14315	COG1126	abc transporter atp-binding protein
I6G97_RS14320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G97_RS14325	COG4215	(ABC) transporter
I6G97_RS14330	COG4160	amino acid transport
I6G97_RS14335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G97_RS14340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G97_RS14365	COG0778	Nitroreductase
I6G97_RS14395	COG0697	spore germination
I6G97_RS14415	COG0671	phosphoesterase, PA-phosphatase related
I6G97_RS14420	COG1349	DNA-binding transcription factor activity
I6G97_RS14425	COG0814	amino acid
I6G97_RS14430	COG1760	l-serine dehydratase
I6G97_RS14435	COG1686	Belongs to the peptidase S11 family
I6G97_RS14440	COG1881	PFAM PEBP family protein
I6G97_RS14445	COG2207	Transcriptional regulator
I6G97_RS14450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G97_RS14455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G97_RS14470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6G97_RS14480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G97_RS14480	COG0131	Imidazoleglycerol-phosphate dehydratase
I6G97_RS14505	COG3005	denitrification pathway
I6G97_RS14510	COG0243	molybdopterin cofactor binding
I6G97_RS14540	COG0246	Mannitol dehydrogenase
I6G97_RS14545	COG2200	EAL domain
I6G97_RS14550	COG2186	Transcriptional regulator
I6G97_RS14555	COG0523	cobalamin synthesis protein
I6G97_RS14560	COG0791	NLP P60 protein
I6G97_RS14565	COG1113	amino acid transport
I6G97_RS14570	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6G97_RS14570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G97_RS14570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G97_RS14575	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G97_RS14580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G97_RS14580	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G97_RS14590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G97_RS14595	COG0765	amino acid transport
I6G97_RS14600	COG1126	abc transporter atp-binding protein
I6G97_RS14605	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6G97_RS14610	COG4166	transmembrane transport
I6G97_RS14620	COG2814	Major facilitator Superfamily
I6G97_RS14625	COG1187	pseudouridine synthase activity
I6G97_RS14635	COG1061	Type III restriction enzyme res subunit
I6G97_RS14665	COG3708	Transcriptional regulator
I6G97_RS14665	COG2207	Transcriptional regulator
I6G97_RS14715	COG0148	phosphopyruvate hydratase activity
I6G97_RS14720	COG0589	response to stress
I6G97_RS14725	COG1227	inorganic diphosphatase activity
I6G97_RS14730	COG1309	transcriptional regulator
I6G97_RS14735	COG4977	sequence-specific DNA binding
I6G97_RS14740	COG0513	Belongs to the DEAD box helicase family
I6G97_RS14745	COG1309	transcriptional regulator
I6G97_RS14750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G97_RS14755	COG1131	(ABC) transporter
I6G97_RS14760	COG0842	Transport permease protein
I6G97_RS14765	COG0842	Transport permease protein
I6G97_RS14770	COG2198	Histidine kinase
I6G97_RS14770	COG0642	Histidine kinase
I6G97_RS14780	COG2205	protein histidine kinase activity
I6G97_RS14780	COG0784	Response regulator, receiver
I6G97_RS14790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G97_RS14805	COG0633	Ferredoxin
I6G97_RS14810	COG0243	molybdopterin cofactor binding
I6G97_RS14815	COG0670	Belongs to the BI1 family
I6G97_RS14825	COG0314	molybdopterin synthase activity
I6G97_RS14830	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6G97_RS14845	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6G97_RS14855	COG0814	amino acid
I6G97_RS14860	COG0180	Tryptophanyl-tRNA synthetase
I6G97_RS14880	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G97_RS14885	COG0596	Alpha beta hydrolase
I6G97_RS14895	COG1169	isochorismate synthase
I6G97_RS14910	COG1773	rubredoxin
I6G97_RS14915	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G97_RS14920	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6G97_RS14925	COG5557	Pfam Polysulphide reductase, NrfD
I6G97_RS14930	COG0437	4 iron, 4 sulfur cluster binding
I6G97_RS14935	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6G97_RS14940	COG3038	cytochrome b561
I6G97_RS14955	COG1007	ATP synthesis coupled electron transport
I6G97_RS14960	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G97_RS14965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G97_RS14975	COG0839	Belongs to the complex I subunit 6 family
I6G97_RS14995	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6G97_RS15020	COG0583	DNA-binding transcription factor activity
I6G97_RS15025	COG0398	Pfam SNARE associated Golgi protein
I6G97_RS15030	COG2897	thiosulfate sulfurtransferase activity
I6G97_RS15035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G97_RS15040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G97_RS15045	COG0436	Aminotransferase
I6G97_RS15050	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6G97_RS15055	COG0471	metal ion transport
I6G97_RS15055	COG0490	domain, Protein
I6G97_RS15060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G97_RS15075	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G97_RS15080	COG0857	belongs to the CobB CobQ family
I6G97_RS15080	COG0280	phosphate acetyltransferase
I6G97_RS15085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G97_RS15090	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6G97_RS15095	COG0622	Phosphoesterase
I6G97_RS15100	COG0625	glutathione transferase activity
I6G97_RS15105	COG0625	glutathione transferase activity
I6G97_RS15110	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G97_RS15115	COG1090	epimerase
I6G97_RS15120	COG1028	Short-chain dehydrogenase reductase Sdr
I6G97_RS15125	COG0163	prenyltransferase activity
I6G97_RS15130	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6G97_RS15135	COG1286	toxin biosynthetic process
I6G97_RS15140	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6G97_RS15145	COG0285	dihydrofolate synthase activity
I6G97_RS15150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G97_RS15155	COG0586	Pfam SNARE associated Golgi protein
I6G97_RS15165	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G97_RS15175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G97_RS15195	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G97_RS15225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G97_RS15230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G97_RS15230	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6G97_RS15240	COG3101	peptidyl-lysine hydroxylation
I6G97_RS15245	COG0730	response to heat
I6G97_RS15260	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G97_RS15270	COG2062	phosphohistidine phosphatase, SixA
I6G97_RS15275	COG3691	Protein conserved in bacteria
I6G97_RS15280	COG2067	long-chain fatty acid transport protein
I6G97_RS15290	COG4235	cytochrome complex assembly
I6G97_RS15290	COG3088	subunit of a heme lyase
I6G97_RS15295	COG4235	cytochrome complex assembly
I6G97_RS15295	COG3088	subunit of a heme lyase
I6G97_RS15300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G97_RS15305	COG1138	Cytochrome C-type biogenesis protein
I6G97_RS15310	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6G97_RS15315	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G97_RS15320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G97_RS15325	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G97_RS15440	COG2188	Transcriptional regulator
I6G97_RS15475	COG0493	'glutamate synthase
I6G97_RS15480	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6G97_RS15480	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6G97_RS15480	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6G97_RS15480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6G97_RS15485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G97_RS15490	COG0640	Transcriptional regulator
I6G97_RS15495	COG2951	lytic endotransglycosylase activity
I6G97_RS15505	COG1966	Carbon starvation protein
I6G97_RS15510	COG2879	small protein
I6G97_RS15515	COG0523	cobalamin synthesis protein
I6G97_RS15540	COG4574	serine-type endopeptidase inhibitor activity
I6G97_RS15545	COG0488	(ABC) transporter
I6G97_RS15550	COG0583	DNA-binding transcription factor activity
I6G97_RS15555	COG0840	transmembrane signaling receptor activity
I6G97_RS15580	COG3119	arylsulfatase activity
I6G97_RS15585	COG0641	radical SAM
I6G97_RS15590	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6G97_RS15595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G97_RS15605	COG3716	PTS system mannose fructose sorbose family IID component
I6G97_RS15610	COG3715	PTS system
I6G97_RS15615	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G97_RS15620	COG2222	sugar isomerase
I6G97_RS15630	COG1349	DNA-binding transcription factor activity
I6G97_RS15635	COG2354	Protein conserved in bacteria
I6G97_RS15640	COG1686	Belongs to the peptidase S11 family
I6G97_RS15650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G97_RS15655	COG4628	conserved protein (DUF2132)
I6G97_RS15695	COG0561	phosphatase activity
I6G97_RS15705	COG4149	molybdate abc transporter
I6G97_RS15710	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G97_RS15715	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6G97_RS15750	COG3585	molybdate ion transport
I6G97_RS15750	COG2005	Transcriptional regulator
I6G97_RS15760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G97_RS15765	COG1085	galactose-1-phosphate uridylyltransferase
I6G97_RS15770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6G97_RS15775	COG2017	converts alpha-aldose to the beta-anomer
I6G97_RS15780	COG0471	metal ion transport
I6G97_RS15790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G97_RS15820	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6G97_RS15825	COG2885	chlorophyll binding
I6G97_RS15835	COG3064	Membrane
I6G97_RS15835	COG3064	Membrane
I6G97_RS15840	COG0848	biopolymer transport protein
I6G97_RS15845	COG0811	peptide transport
I6G97_RS15850	COG0824	Thioesterase
I6G97_RS15855	COG3790	cyd operon protein YbgE
I6G97_RS15860	COG4890	Cyd operon protein YbgT
I6G97_RS15865	COG1294	oxidase, subunit
I6G97_RS15870	COG1271	oxidase subunit
I6G97_RS15875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G97_RS15885	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G97_RS15890	COG0567	Dehydrogenase, E1 component
I6G97_RS15900	COG1053	succinate dehydrogenase
I6G97_RS15905	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6G97_RS15925	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G97_RS15930	COG2771	luxR family
I6G97_RS15940	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G97_RS15945	COG5212	phosphodiesterase
I6G97_RS15955	COG3272	Protein of unknown function (DUF1722)
I6G97_RS15970	COG0583	DNA-binding transcription factor activity
I6G97_RS15985	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6G97_RS15990	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6G97_RS15995	COG2205	protein histidine kinase activity
I6G97_RS16000	COG0745	RESPONSE REGULATOR receiver
I6G97_RS16005	COG0033	Phosphoglucomutase
I6G97_RS16010	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6G97_RS16015	COG0596	Alpha beta hydrolase
I6G97_RS16025	COG0716	FMN binding
I6G97_RS16030	COG0735	belongs to the Fur family
I6G97_RS16055	COG1263	PTS System
I6G97_RS16055	COG2190	(PTS) system
I6G97_RS16055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G97_RS16065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G97_RS16070	COG1846	Transcriptional regulator
I6G97_RS16070	COG1940	carbohydrate kinase activity
I6G97_RS16075	COG0647	UMP catabolic process
I6G97_RS16080	COG0367	asparagine synthase
I6G97_RS16120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G97_RS16130	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6G97_RS16135	COG1702	phosphate starvation-inducible protein PhoH
I6G97_RS16145	COG4535	Mg2 and Co2 transporter CorC
I6G97_RS16150	COG0686	Belongs to the AlaDH PNT family
I6G97_RS16155	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G97_RS16165	COG0765	amino acid transport
I6G97_RS16170	COG0765	amino acid transport
I6G97_RS16175	COG1126	abc transporter atp-binding protein
I6G97_RS16190	COG2888	peptidyl-tyrosine sulfation
I6G97_RS16200	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I6G97_RS16205	COG1466	dna polymerase III delta subunit
I6G97_RS16215	COG0799	negative regulation of ribosome biogenesis
I6G97_RS16225	COG0768	penicillin binding
I6G97_RS16230	COG0772	Belongs to the SEDS family
I6G97_RS16235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G97_RS16240	COG1686	Belongs to the peptidase S11 family
I6G97_RS16270	COG4989	oxidoreductase activity
I6G97_RS16275	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6G97_RS16295	COG1024	Enoyl-CoA hydratase
I6G97_RS16330	COG0644	oxidoreductase
I6G97_RS16335	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6G97_RS16340	COG2271	Major facilitator Superfamily
I6G97_RS16345	COG0657	acetylesterase activity
I6G97_RS16360	COG0157	Belongs to the NadC ModD family
I6G97_RS16375	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G97_RS16410	COG1475	DNA binding
I6G97_RS16415	COG3969	phosphoadenosine phosphosulfate
I6G97_RS16420	COG3158	transport of potassium into the cell
I6G97_RS16425	COG0058	SHG alpha-glucan phosphorylase activity
I6G97_RS16450	COG0754	glutathionylspermidine amidase activity
I6G97_RS16510	COG2501	S4 domain
I6G97_RS16520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G97_RS16530	COG3706	GGDEF domain
I6G97_RS16535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G97_RS16540	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G97_RS16545	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6G97_RS16550	COG4181	ATPase activity
I6G97_RS16555	COG2755	lipolytic protein G-D-S-L family
I6G97_RS16560	COG0300	oxidoreductase activity
I6G97_RS16565	COG3118	belongs to the thioredoxin family
I6G97_RS16570	COG3366	ferrous iron transmembrane transporter activity
I6G97_RS16575	COG0700	Nucleoside recognition
I6G97_RS16590	COG2841	Protein conserved in bacteria
I6G97_RS16605	COG3956	TIGRFAM MazG family protein
I6G97_RS16610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G97_RS16640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G97_RS16650	COG0681	Belongs to the peptidase S26 family
I6G97_RS16660	COG3086	response to oxidative stress
I6G97_RS16690	COG0513	Belongs to the DEAD box helicase family
I6G97_RS16700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G97_RS16705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G97_RS16715	COG0497	DNA recombination
I6G97_RS16720	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G97_RS16730	COG2867	negative regulation of translational initiation
I6G97_RS16750	COG1953	Uracil, thiamine, allantoin
I6G97_RS16760	COG2207	Transcriptional regulator
I6G97_RS16770	COG5001	Diguanylate cyclase
I6G97_RS16770	COG4251	negative regulation of phosphorylation
I6G97_RS16770	COG3706	GGDEF domain
I6G97_RS16770	COG2203	Gaf domain
I6G97_RS16780	COG0583	DNA-binding transcription factor activity
I6G97_RS16795	COG1846	Transcriptional regulator
I6G97_RS16800	COG1566	PFAM secretion protein HlyD family protein
I6G97_RS16805	COG2814	Major facilitator Superfamily
I6G97_RS16810	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G97_RS16820	COG3842	ATPase activity
I6G97_RS16825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G97_RS16830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6G97_RS16845	COG2860	membrane
I6G97_RS16880	COG0517	IMP dehydrogenase activity
I6G97_RS16880	COG0516	GMP reductase activity
I6G97_RS16890	COG4235	cytochrome complex assembly
I6G97_RS16895	COG3088	subunit of a heme lyase
I6G97_RS16900	COG1138	Cytochrome C-type biogenesis protein
I6G97_RS16905	COG3301	Polysulphide reductase, NrfD
I6G97_RS16910	COG0437	4 iron, 4 sulfur cluster binding
I6G97_RS16915	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6G97_RS16925	COG1645	bacterial-type flagellum-dependent swarming motility
I6G97_RS16940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G97_RS16945	COG2976	Protein conserved in bacteria
I6G97_RS16955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6G97_RS16990	COG2975	iron-sulfur cluster assembly
I6G97_RS16995	COG0633	Ferredoxin
I6G97_RS17015	COG0822	iron-sulfur transferase activity
I6G97_RS17030	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6G97_RS17035	COG0483	inositol monophosphate 1-phosphatase activity
I6G97_RS17050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G97_RS17050	COG1017	nitric oxide dioxygenase activity
I6G97_RS17055	COG0582	viral genome integration into host DNA
I6G97_RS17070	COG4983	Phage plasmid primase, P4 family domain protein
I6G97_RS17110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G97_RS17130	COG3596	GTP binding
I6G97_RS17135	COG2378	regulation of single-species biofilm formation
I6G97_RS17145	COG2378	regulation of single-species biofilm formation
I6G97_RS17180	COG2003	Belongs to the UPF0758 family
I6G97_RS17230	COG2226	methyltransferase
I6G97_RS17240	COG0741	lytic transglycosylase activity
I6G97_RS17240	COG1388	LysM domain
I6G97_RS17245	COG3021	interspecies interaction between organisms
I6G97_RS17275	COG0542	response to heat
I6G97_RS17285	COG0564	pseudouridine synthase activity
I6G97_RS17290	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G97_RS17295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G97_RS17300	COG0077	Prephenate dehydratase
I6G97_RS17300	COG1605	Chorismate mutase
I6G97_RS17305	COG1605	Chorismate mutase
I6G97_RS17305	COG0287	Prephenate dehydrogenase
I6G97_RS17310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G97_RS17315	COG3279	Response regulator of the LytR AlgR family
I6G97_RS17330	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G97_RS17335	COG3137	Salt-induced outer membrane protein
I6G97_RS17345	COG0335	large ribosomal subunit rRNA binding
I6G97_RS17365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G97_RS17370	COG4137	Cytochrome C assembly protein
I6G97_RS17375	COG4536	flavin adenine dinucleotide binding
I6G97_RS17390	COG1238	metal cluster binding
I6G97_RS17425	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6G97_RS17435	COG2137	regulation of response to DNA damage stimulus
I6G97_RS17445	COG1546	Belongs to the CinA family
I6G97_RS17460	COG0531	amino acid
I6G97_RS17470	COG0531	amino acid
I6G97_RS17475	COG0076	glutamate decarboxylase activity
I6G97_RS17480	COG0840	transmembrane signaling receptor activity
I6G97_RS17505	COG1388	LysM domain
I6G97_RS17505	COG4942	peptidase
I6G97_RS17510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6G97_RS17550	COG3066	DNA modification
I6G97_RS17555	COG0861	Integral membrane protein TerC family
I6G97_RS17565	COG1785	Belongs to the alkaline phosphatase family
I6G97_RS17575	COG0204	Acyl-transferase
I6G97_RS17575	COG0318	PFAM AMP-dependent synthetase and ligase
I6G97_RS17580	COG1609	Transcriptional regulator
I6G97_RS17585	COG1609	Transcriptional regulator
I6G97_RS17590	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein