locus-tag	class	description
ECH_RS00020	COG1475	DNA binding
ECH_RS00025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ECH_RS00030	COG0336	Belongs to the RNA methyltransferase TrmD family
ECH_RS00035	COG0335	large ribosomal subunit rRNA binding
ECH_RS00045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ECH_RS00050	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ECH_RS00055	COG0802	atpase or kinase
ECH_RS00060	COG0670	Belongs to the BI1 family
ECH_RS00070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ECH_RS00075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ECH_RS00080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ECH_RS00085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ECH_RS00090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ECH_RS00095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ECH_RS00100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ECH_RS00110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ECH_RS00125	COG0752	glycyl-tRNA synthetase alpha subunit
ECH_RS00130	COG0751	glycine-tRNA ligase activity
ECH_RS00135	COG0484	heat shock protein binding
ECH_RS00145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ECH_RS00150	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ECH_RS00155	COG1845	cytochrome c oxidase, subunit III
ECH_RS00160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ECH_RS00165	COG1253	flavin adenine dinucleotide binding
ECH_RS00175	COG4695	Portal protein
ECH_RS00180	COG4106	trans-aconitate 2-methyltransferase activity
ECH_RS00185	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ECH_RS00195	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ECH_RS00210	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ECH_RS00230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ECH_RS00260	COG0126	phosphoglycerate kinase activity
ECH_RS00280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ECH_RS00285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ECH_RS00290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ECH_RS00315	COG1230	cation diffusion facilitator family transporter
ECH_RS00325	COG0268	Binds directly to 16S ribosomal RNA
ECH_RS00335	COG0242	peptide deformylase activity
ECH_RS00340	COG1573	uracil-dna glycosylase
ECH_RS00350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ECH_RS00365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ECH_RS00370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ECH_RS00375	COG1127	ABC transporter
ECH_RS00385	COG0142	geranyltranstransferase activity
ECH_RS00390	COG0174	glutamine synthetase
ECH_RS00400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ECH_RS00405	COG0156	8-amino-7-oxononanoate synthase activity
ECH_RS00410	COG0792	nuclease activity
ECH_RS00425	COG1830	Aldolase
ECH_RS00500	COG0519	Catalyzes the synthesis of GMP from XMP
ECH_RS00500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ECH_RS00505	COG0372	Belongs to the citrate synthase family
ECH_RS00540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ECH_RS00545	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ECH_RS00550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ECH_RS00555	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ECH_RS00555	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ECH_RS00560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ECH_RS00565	COG0525	valine-tRNA ligase activity
ECH_RS00570	COG1138	Cytochrome C-type biogenesis protein
ECH_RS00575	COG0354	folic acid binding
ECH_RS00580	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ECH_RS00590	COG0193	aminoacyl-tRNA hydrolase activity
ECH_RS00595	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ECH_RS00605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ECH_RS00620	COG1981	membrane
ECH_RS00625	COG0022	dehydrogenase e1 component
ECH_RS00625	COG0508	dehydrogenase complex catalyzes the overall conversion of
ECH_RS00640	COG0312	modulator of DNA gyrase
ECH_RS00645	COG0012	GTP binding
ECH_RS00650	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ECH_RS00655	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ECH_RS00655	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ECH_RS00670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ECH_RS00680	COG0776	regulation of translation
ECH_RS00700	COG0180	Tryptophanyl-tRNA synthetase
ECH_RS00705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ECH_RS00710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ECH_RS00710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ECH_RS00720	COG0504	CTP synthase activity
ECH_RS00730	COG4974	Belongs to the 'phage' integrase family
ECH_RS00735	COG1136	(ABC) transporter
ECH_RS00740	COG0280	phosphate acetyltransferase
ECH_RS00740	COG0281	malic enzyme
ECH_RS00750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ECH_RS00755	COG0651	ATP synthesis coupled electron transport
ECH_RS00775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ECH_RS00795	COG1840	ABC-type Fe3 transport system, periplasmic component
ECH_RS00800	COG0228	four-way junction DNA binding
ECH_RS00805	COG0477	Major facilitator Superfamily
ECH_RS00810	COG2835	tetraacyldisaccharide 4'-kinase activity
ECH_RS00815	COG1028	Short-chain dehydrogenase reductase Sdr
ECH_RS00820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ECH_RS00825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ECH_RS00830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ECH_RS00840	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ECH_RS00850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ECH_RS00865	COG2022	thiamine diphosphate biosynthetic process
ECH_RS00875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ECH_RS00890	COG0742	ribosomal rna small subunit methyltransferase
ECH_RS00905	COG1722	exodeoxyribonuclease VII activity
ECH_RS00910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ECH_RS00915	COG3118	belongs to the thioredoxin family
ECH_RS00925	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ECH_RS00930	COG2267	carboxylic ester hydrolase activity
ECH_RS00945	COG0517	IMP dehydrogenase activity
ECH_RS00945	COG0516	GMP reductase activity
ECH_RS00960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ECH_RS00965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ECH_RS00980	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ECH_RS00985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ECH_RS00990	COG0612	Peptidase, M16
ECH_RS01030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ECH_RS01075	COG0328	RNA-DNA hybrid ribonuclease activity
ECH_RS01085	COG0528	UMP kinase activity
ECH_RS01090	COG0233	cytoplasmic translational termination
ECH_RS01095	COG4589	Belongs to the CDS family
ECH_RS01120	COG2094	Belongs to the DNA glycosylase MPG family
ECH_RS01155	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ECH_RS01160	COG0124	histidyl-tRNA synthetase
ECH_RS01170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ECH_RS01175	COG1612	heme a metabolic process
ECH_RS01180	COG4133	protoheme IX ABC transporter activity
ECH_RS01185	COG0717	Belongs to the dCTP deaminase family
ECH_RS01200	COG5000	phosphorelay sensor kinase activity
ECH_RS01205	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ECH_RS01210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ECH_RS01215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ECH_RS01225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ECH_RS01230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ECH_RS01245	COG0360	Binds together with S18 to 16S ribosomal RNA
ECH_RS01250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ECH_RS01255	COG0359	binds to the 23S rRNA
ECH_RS01260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ECH_RS01270	COG1132	(ABC) transporter
ECH_RS01290	COG2814	Major facilitator Superfamily
ECH_RS01295	COG2255	four-way junction helicase activity
ECH_RS01300	COG0632	four-way junction helicase activity
ECH_RS01305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ECH_RS01310	COG0194	GDP metabolic process
ECH_RS01315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ECH_RS01330	COG3474	cytochrome
ECH_RS01335	COG2111	Na H antiporter
ECH_RS01335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ECH_RS01345	COG0574	Belongs to the PEP-utilizing enzyme family
ECH_RS01345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ECH_RS01360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ECH_RS01365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ECH_RS01385	COG2204	response regulator
ECH_RS01390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ECH_RS01395	COG4974	Belongs to the 'phage' integrase family
ECH_RS01400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ECH_RS01415	COG0799	negative regulation of ribosome biogenesis
ECH_RS01420	COG4783	chaperone-mediated protein folding
ECH_RS01435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ECH_RS01440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ECH_RS01460	COG1494	fructose-1,6-bisphosphatase
ECH_RS01465	COG0445	tRNA wobble uridine modification
ECH_RS01470	COG0047	phosphoribosylformylglycinamidine synthase activity
ECH_RS01475	COG2003	Belongs to the UPF0758 family
ECH_RS01480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ECH_RS01490	COG4221	oxidoreductase activity
ECH_RS01495	COG0542	response to heat
ECH_RS01505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ECH_RS01510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ECH_RS01515	COG0321	lipoyl(octanoyl) transferase activity
ECH_RS01520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ECH_RS01525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ECH_RS01530	COG0114	fumarate hydratase activity
ECH_RS01540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ECH_RS01550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ECH_RS01560	COG0604	alcohol dehydrogenase
ECH_RS01565	COG1074	ATP-dependent DNA helicase activity
ECH_RS01595	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ECH_RS01625	COG0776	regulation of translation
ECH_RS01630	COG0616	signal peptide processing
ECH_RS01635	COG0539	negative regulation of cytoplasmic translation
ECH_RS01645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ECH_RS01660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ECH_RS01665	COG0051	transcription antitermination factor activity, RNA binding
ECH_RS01670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ECH_RS01675	COG0088	Forms part of the polypeptide exit tunnel
ECH_RS01680	COG0089	rRNA binding
ECH_RS01685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ECH_RS01690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ECH_RS01695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ECH_RS01700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ECH_RS01705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ECH_RS01710	COG0255	Belongs to the universal ribosomal protein uL29 family
ECH_RS01715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ECH_RS01720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ECH_RS01725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ECH_RS01730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ECH_RS01735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ECH_RS01740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ECH_RS01745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ECH_RS01750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ECH_RS01755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ECH_RS01760	COG0200	Binds to the 23S rRNA
ECH_RS01765	COG0201	protein transport
ECH_RS01775	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ECH_RS01780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ECH_RS01785	COG0202	RNA polymerase activity
ECH_RS01790	COG0203	ribosomal protein L17
ECH_RS01795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ECH_RS01795	COG0072	phenylalanine-tRNA ligase activity
ECH_RS01800	COG0658	competence protein
ECH_RS01800	COG2333	competence protein COMEC
ECH_RS01805	COG1115	amino acid carrier protein
ECH_RS01815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ECH_RS01820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ECH_RS01825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ECH_RS01835	COG0343	queuine tRNA-ribosyltransferase activity
ECH_RS01840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ECH_RS01845	COG0416	fatty acid biosynthetic process
ECH_RS01850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ECH_RS01855	COG0590	tRNA wobble adenosine to inosine editing
ECH_RS01865	COG0305	Participates in initiation and elongation during chromosome replication
ECH_RS01890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ECH_RS01895	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ECH_RS01900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ECH_RS01905	COG2885	chlorophyll binding
ECH_RS01915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ECH_RS01925	COG1320	monovalent cation:proton antiporter activity
ECH_RS01945	COG1530	ribonuclease E activity
ECH_RS01950	COG0443	Heat shock 70 kDa protein
ECH_RS01955	COG2867	negative regulation of translational initiation
ECH_RS01960	COG1007	ATP synthesis coupled electron transport
ECH_RS01970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ECH_RS01980	COG3577	Aspartyl protease
ECH_RS01985	COG0006	proline dipeptidase activity
ECH_RS02005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ECH_RS02010	COG0019	diaminopimelate decarboxylase activity
ECH_RS02015	COG0564	pseudouridine synthase activity
ECH_RS02020	COG4770	biotin carboxylase activity
ECH_RS02035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ECH_RS02045	COG0581	inorganic phosphate transmembrane transporter activity
ECH_RS02050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ECH_RS02060	COG3451	type IV secretory pathway VirB4
ECH_RS02065	COG3704	protein secretion by the type IV secretion system
ECH_RS02070	COG3704	protein secretion by the type IV secretion system
ECH_RS02075	COG3704	protein secretion by the type IV secretion system
ECH_RS02075	COG1340	protein secretion by the type IV secretion system
ECH_RS02090	COG0756	dUTP diphosphatase activity
ECH_RS02095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ECH_RS02100	COG0505	Belongs to the CarA family
ECH_RS02105	COG1160	GTP binding
ECH_RS02110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ECH_RS02120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ECH_RS02130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ECH_RS02135	COG0424	maF-like protein
ECH_RS02140	COG0052	Belongs to the universal ribosomal protein uS2 family
ECH_RS02145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ECH_RS02155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ECH_RS02165	COG0723	plastoquinol--plastocyanin reductase activity
ECH_RS02170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ECH_RS02200	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ECH_RS02215	COG0606	chelatase, subunit chli
ECH_RS02220	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ECH_RS02235	COG1381	Involved in DNA repair and RecF pathway recombination
ECH_RS02240	COG0018	arginyl-trna synthetase
ECH_RS02245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ECH_RS02250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ECH_RS02265	COG0275	rRNA processing
ECH_RS02270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ECH_RS02275	COG0148	phosphopyruvate hydratase activity
ECH_RS02280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ECH_RS02285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ECH_RS02315	COG0713	ATP synthesis coupled electron transport
ECH_RS02320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ECH_RS02335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ECH_RS02345	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ECH_RS02350	COG0805	protein transport
ECH_RS02355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ECH_RS02360	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ECH_RS02360	COG0195	Participates in both transcription termination and antitermination
ECH_RS02365	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ECH_RS02375	COG0861	Integral membrane protein TerC family
ECH_RS02410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ECH_RS02420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ECH_RS02425	COG3750	Belongs to the UPF0335 family
ECH_RS02445	COG1301	dicarboxylic acid transport
ECH_RS02455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ECH_RS02470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ECH_RS02475	COG0408	coproporphyrinogen oxidase activity
ECH_RS02485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ECH_RS02490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ECH_RS02495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ECH_RS02500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ECH_RS02515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ECH_RS02525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ECH_RS02565	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ECH_RS02570	COG0649	NAD binding
ECH_RS02575	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ECH_RS02580	COG1034	ATP synthesis coupled electron transport
ECH_RS02590	COG0187	DNA topoisomerase II activity
ECH_RS02595	COG0540	Belongs to the ATCase OTCase family
ECH_RS02600	COG0101	tRNA pseudouridine synthase activity
ECH_RS02605	COG0736	holo-[acyl-carrier-protein] synthase activity
ECH_RS02615	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ECH_RS02620	COG2945	thiolester hydrolase activity
ECH_RS02625	COG1104	cysteine desulfurase activity
ECH_RS02630	COG1104	cysteine desulfurase activity
ECH_RS02635	COG0822	iron-sulfur transferase activity
ECH_RS02640	COG0316	Belongs to the HesB IscA family
ECH_RS02650	COG0443	Heat shock 70 kDa protein
ECH_RS02665	COG3088	subunit of a heme lyase
ECH_RS02670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ECH_RS02675	COG0698	ribose 5-phosphate isomerase
ECH_RS02690	COG0039	L-malate dehydrogenase activity
ECH_RS02705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ECH_RS02715	COG0149	triose-phosphate isomerase activity
ECH_RS02725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ECH_RS02730	COG0492	ferredoxin-NADP+ reductase activity
ECH_RS02735	COG0312	modulator of DNA gyrase
ECH_RS02740	COG0302	gtp cyclohydrolase
ECH_RS02745	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ECH_RS02760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ECH_RS02765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ECH_RS02810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ECH_RS02835	COG0708	Exodeoxyribonuclease III
ECH_RS02855	COG0137	argininosuccinate synthase activity
ECH_RS02875	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ECH_RS02885	COG0681	Belongs to the peptidase S26 family
ECH_RS02890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ECH_RS02900	COG1217	gtp-binding protein TYPA
ECH_RS02930	COG0181	hydroxymethylbilane synthase activity
ECH_RS02935	COG0285	dihydrofolate synthase activity
ECH_RS02940	COG0154	amidase activity
ECH_RS02945	COG0217	transcriptional regulatory protein
ECH_RS02950	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ECH_RS03005	COG0481	GTPase activity
ECH_RS03010	COG2226	methyltransferase
ECH_RS03015	COG1185	polyribonucleotide nucleotidyltransferase activity
ECH_RS03020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ECH_RS03025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ECH_RS03035	COG1214	PFAM Peptidase M22, glycoprotease
ECH_RS03040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ECH_RS03045	COG0436	Aminotransferase
ECH_RS03050	COG0450	alkyl hydroperoxide reductase
ECH_RS03055	COG0492	ferredoxin-NADP+ reductase activity
ECH_RS03060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ECH_RS03075	COG0442	prolyl-tRNA aminoacylation
ECH_RS03080	COG0736	holo-[acyl-carrier-protein] synthase activity
ECH_RS03105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ECH_RS03110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ECH_RS03110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ECH_RS03135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ECH_RS03140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ECH_RS03145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ECH_RS03150	COG0358	DNA primase activity
ECH_RS03175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ECH_RS03185	COG0215	cysteine-tRNA ligase activity
ECH_RS03190	COG3932	Exopolysaccharide synthesis, ExoD
ECH_RS03195	COG2902	Dehydrogenase
ECH_RS03210	COG0564	pseudouridine synthase activity
ECH_RS03220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ECH_RS03225	COG0543	2 iron, 2 sulfur cluster binding
ECH_RS03225	COG0493	'glutamate synthase
ECH_RS03230	COG0688	phosphatidylethanolamine metabolic process
ECH_RS03235	COG1183	phosphatidylcholine synthase activity
ECH_RS03240	COG1115	amino acid carrier protein
ECH_RS03245	COG0706	membrane insertase activity
ECH_RS03260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ECH_RS03265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ECH_RS03270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ECH_RS03275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ECH_RS03280	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ECH_RS03285	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ECH_RS03290	COG0284	orotidine-5'-phosphate decarboxylase activity
ECH_RS03295	COG0084	hydrolase, TatD family'
ECH_RS03300	COG0495	leucyl-tRNA aminoacylation
ECH_RS03310	COG1758	RNA polymerase activity
ECH_RS03320	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ECH_RS03325	COG0237	dephospho-CoA kinase activity
ECH_RS03330	COG0009	L-threonylcarbamoyladenylate synthase
ECH_RS03345	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ECH_RS03350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ECH_RS03360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ECH_RS03365	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ECH_RS03370	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ECH_RS03380	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ECH_RS03390	COG0629	single-stranded DNA binding
ECH_RS03395	COG0477	Major facilitator Superfamily
ECH_RS03400	COG0477	Major facilitator Superfamily
ECH_RS03410	COG0113	porphobilinogen synthase activity
ECH_RS03420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ECH_RS03430	COG0537	adenosine 5'-monophosphoramidase activity
ECH_RS03435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ECH_RS03445	COG0567	Dehydrogenase, E1 component
ECH_RS03460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ECH_RS03475	COG1121	(ABC) transporter
ECH_RS03485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ECH_RS03490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ECH_RS03495	COG3842	ATPase activity
ECH_RS03505	COG0625	glutathione transferase activity
ECH_RS03525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ECH_RS03530	COG0326	Molecular chaperone. Has ATPase activity
ECH_RS03540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ECH_RS03545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ECH_RS03550	COG0210	DNA helicase
ECH_RS03580	COG0482	sulfurtransferase activity
ECH_RS03585	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ECH_RS03600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ECH_RS03620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ECH_RS03625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ECH_RS03630	COG0758	DNA mediated transformation
ECH_RS03635	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ECH_RS03640	COG2202	Pas domain
ECH_RS03640	COG2205	protein histidine kinase activity
ECH_RS03645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ECH_RS03665	COG4536	flavin adenine dinucleotide binding
ECH_RS03675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ECH_RS03680	COG1054	Belongs to the UPF0176 family
ECH_RS03685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ECH_RS03695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ECH_RS03700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ECH_RS03705	COG0740	serine-type endopeptidase activity
ECH_RS03710	COG0544	peptidyl-prolyl cis-trans isomerase activity
ECH_RS03745	COG0628	permease
ECH_RS03755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ECH_RS03765	COG0351	phosphomethylpyrimidine kinase
ECH_RS03765	COG0352	thiamine-phosphate diphosphorylase activity
ECH_RS03775	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ECH_RS03780	COG2009	succinate dehydrogenase
ECH_RS03790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ECH_RS03810	COG0271	Belongs to the BolA IbaG family
ECH_RS03815	COG0259	pyridoxamine-phosphate oxidase activity
ECH_RS03830	COG0165	Argininosuccinate lyase
ECH_RS03835	COG0242	peptide deformylase activity
ECH_RS03840	COG0167	dihydroorotate dehydrogenase activity
ECH_RS03845	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ECH_RS03865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ECH_RS03880	COG0156	8-amino-7-oxononanoate synthase activity
ECH_RS03885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ECH_RS03890	COG0085	RNA polymerase activity
ECH_RS03895	COG0222	ribosome binding
ECH_RS03900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ECH_RS03905	COG0081	regulation of translation
ECH_RS03910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ECH_RS03930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ECH_RS03935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ECH_RS03940	COG0049	tRNA binding
ECH_RS03945	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ECH_RS03970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ECH_RS03975	COG1178	ABC-type Fe3 transport system permease component
ECH_RS04000	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ECH_RS04005	COG0045	succinate-CoA ligase (ADP-forming) activity
ECH_RS04015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ECH_RS04020	COG0573	inorganic phosphate transmembrane transporter activity
ECH_RS04025	COG0174	glutamine synthetase
ECH_RS04060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ECH_RS04065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ECH_RS04070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ECH_RS04075	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ECH_RS04080	COG2226	methyltransferase
ECH_RS04085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ECH_RS04090	COG0527	aspartate kinase activity
ECH_RS04095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ECH_RS04100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ECH_RS04105	COG0109	protoheme IX farnesyltransferase activity
ECH_RS04110	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ECH_RS04120	COG1862	Preprotein translocase
ECH_RS04140	COG0745	RESPONSE REGULATOR receiver
ECH_RS04150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ECH_RS04155	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ECH_RS04165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ECH_RS04180	COG0489	protein tyrosine kinase activity
ECH_RS04185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ECH_RS04190	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ECH_RS04195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ECH_RS04205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ECH_RS04235	COG3451	type IV secretory pathway VirB4
ECH_RS04265	COG0330	HflC and HflK could
ECH_RS04270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ECH_RS04280	COG0571	ribonuclease III activity
ECH_RS04290	COG0612	Peptidase, M16
ECH_RS04305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ECH_RS04310	COG0196	riboflavin kinase activity
ECH_RS04315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ECH_RS04320	COG2890	protein-(glutamine-N5) methyltransferase activity
ECH_RS04325	COG0024	Methionine aminopeptidase
ECH_RS04330	COG0508	dehydrogenase complex catalyzes the overall conversion of
ECH_RS04340	COG1686	Belongs to the peptidase S11 family
ECH_RS04355	COG0750	zinc metalloprotease
ECH_RS04370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ECH_RS04375	COG0138	bifunctional purine biosynthesis protein purh
ECH_RS04380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ECH_RS04385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ECH_RS04390	COG3346	SURF1 family
ECH_RS04400	COG0371	Dehydrogenase
ECH_RS04405	COG0356	it plays a direct role in the translocation of protons across the membrane
ECH_RS04410	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ECH_RS04415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ECH_RS04425	COG0849	cell division
ECH_RS04430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ECH_RS04440	COG0037	tRNA processing
ECH_RS04445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ECH_RS04450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ECH_RS04465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ECH_RS04470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ECH_RS04475	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ECH_RS04480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ECH_RS04485	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ECH_RS04490	COG0552	protein localization to endoplasmic reticulum
ECH_RS04495	COG0473	3-isopropylmalate dehydrogenase activity
ECH_RS04500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ECH_RS04500	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ECH_RS04505	COG0617	tRNA 3'-terminal CCA addition
ECH_RS04510	COG0105	UTP biosynthetic process
ECH_RS04515	COG1396	sequence-specific DNA binding
ECH_RS04650	COG0653	protein targeting
ECH_RS04670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA