locus-tag	class	description
FDZ61_RS00005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FDZ61_RS00010	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FDZ61_RS00025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FDZ61_RS00035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FDZ61_RS00040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FDZ61_RS00050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FDZ61_RS00065	COG0752	glycyl-tRNA synthetase alpha subunit
FDZ61_RS00070	COG0751	glycine-tRNA ligase activity
FDZ61_RS00075	COG0484	heat shock protein binding
FDZ61_RS00085	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FDZ61_RS00090	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FDZ61_RS00095	COG1845	cytochrome c oxidase, subunit III
FDZ61_RS00100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FDZ61_RS00105	COG1253	flavin adenine dinucleotide binding
FDZ61_RS00115	COG4695	Portal protein
FDZ61_RS00120	COG2226	methyltransferase
FDZ61_RS00120	COG1073	alpha beta
FDZ61_RS00125	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FDZ61_RS00130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FDZ61_RS00145	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FDZ61_RS00150	COG2948	multi-organism process
FDZ61_RS00165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FDZ61_RS00165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FDZ61_RS00175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FDZ61_RS00195	COG0126	phosphoglycerate kinase activity
FDZ61_RS00210	COG1570	exodeoxyribonuclease VII activity
FDZ61_RS00225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FDZ61_RS00230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FDZ61_RS00235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FDZ61_RS00285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FDZ61_RS00285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FDZ61_RS00290	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FDZ61_RS00290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FDZ61_RS00295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FDZ61_RS00295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FDZ61_RS00305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FDZ61_RS00315	COG1573	uracil-dna glycosylase
FDZ61_RS00320	COG0242	peptide deformylase activity
FDZ61_RS00330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FDZ61_RS00335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FDZ61_RS00350	COG0142	geranyltranstransferase activity
FDZ61_RS00355	COG0174	glutamine synthetase
FDZ61_RS00365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FDZ61_RS00370	COG0156	8-amino-7-oxononanoate synthase activity
FDZ61_RS00390	COG1830	Aldolase
FDZ61_RS00400	COG0508	dehydrogenase complex catalyzes the overall conversion of
FDZ61_RS00435	COG0519	Catalyzes the synthesis of GMP from XMP
FDZ61_RS00450	COG0372	Belongs to the citrate synthase family
FDZ61_RS00465	COG0525	valine-tRNA ligase activity
FDZ61_RS00480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FDZ61_RS00490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FDZ61_RS00530	COG1138	Cytochrome C-type biogenesis protein
FDZ61_RS00540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FDZ61_RS00545	COG0193	aminoacyl-tRNA hydrolase activity
FDZ61_RS00560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FDZ61_RS00580	COG0022	dehydrogenase e1 component
FDZ61_RS00580	COG0508	dehydrogenase complex catalyzes the overall conversion of
FDZ61_RS00595	COG0312	modulator of DNA gyrase
FDZ61_RS00600	COG0012	GTP binding
FDZ61_RS00605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FDZ61_RS00615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FDZ61_RS00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FDZ61_RS00630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FDZ61_RS00640	COG0776	regulation of translation
FDZ61_RS00670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FDZ61_RS00675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FDZ61_RS00675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FDZ61_RS00685	COG0504	CTP synthase activity
FDZ61_RS00695	COG4974	Belongs to the 'phage' integrase family
FDZ61_RS00705	COG0280	phosphate acetyltransferase
FDZ61_RS00705	COG0281	malic enzyme
FDZ61_RS00715	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FDZ61_RS00720	COG0651	ATP synthesis coupled electron transport
FDZ61_RS00760	COG1840	ABC-type Fe3 transport system, periplasmic component
FDZ61_RS00765	COG0228	four-way junction DNA binding
FDZ61_RS00770	COG0477	Major facilitator Superfamily
FDZ61_RS00805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FDZ61_RS00815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FDZ61_RS00840	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FDZ61_RS00840	COG0321	lipoyl(octanoyl) transferase activity
FDZ61_RS00850	COG0573	inorganic phosphate transmembrane transporter activity
FDZ61_RS00855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FDZ61_RS00860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FDZ61_RS00865	COG0045	succinate-CoA ligase (ADP-forming) activity
FDZ61_RS00870	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FDZ61_RS00875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FDZ61_RS00890	COG3038	cytochrome b561
FDZ61_RS00895	COG1178	ABC-type Fe3 transport system permease component
FDZ61_RS00900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FDZ61_RS00925	COG0049	tRNA binding
FDZ61_RS00955	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FDZ61_RS00965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FDZ61_RS00970	COG0222	ribosome binding
FDZ61_RS00975	COG0085	RNA polymerase activity
FDZ61_RS00985	COG0156	8-amino-7-oxononanoate synthase activity
FDZ61_RS01030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FDZ61_RS01035	COG0167	dihydroorotate dehydrogenase activity
FDZ61_RS01040	COG0242	peptide deformylase activity
FDZ61_RS01045	COG0165	Argininosuccinate lyase
FDZ61_RS01060	COG0271	Belongs to the BolA IbaG family
FDZ61_RS01075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FDZ61_RS01090	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FDZ61_RS01100	COG0352	thiamine-phosphate diphosphorylase activity
FDZ61_RS01100	COG0351	phosphomethylpyrimidine kinase
FDZ61_RS01110	COG0628	permease
FDZ61_RS01120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FDZ61_RS01140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FDZ61_RS01160	COG0544	peptidyl-prolyl cis-trans isomerase activity
FDZ61_RS01165	COG0740	serine-type endopeptidase activity
FDZ61_RS01175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FDZ61_RS01185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FDZ61_RS01195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FDZ61_RS01200	COG0352	thiamine-phosphate diphosphorylase activity
FDZ61_RS01205	COG4536	flavin adenine dinucleotide binding
FDZ61_RS01215	COG1674	ftsk spoiiie
FDZ61_RS01225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FDZ61_RS01230	COG2205	protein histidine kinase activity
FDZ61_RS01230	COG2202	Pas domain
FDZ61_RS01235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FDZ61_RS01240	COG0758	DNA mediated transformation
FDZ61_RS01245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FDZ61_RS01250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FDZ61_RS01280	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FDZ61_RS01285	COG0482	sulfurtransferase activity
FDZ61_RS01380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FDZ61_RS01385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FDZ61_RS01395	COG0326	Molecular chaperone. Has ATPase activity
FDZ61_RS01400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FDZ61_RS01440	COG0625	glutathione transferase activity
FDZ61_RS01450	COG3842	ATPase activity
FDZ61_RS01455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FDZ61_RS01460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FDZ61_RS01475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FDZ61_RS01485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FDZ61_RS01515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FDZ61_RS01520	COG0537	adenosine 5'-monophosphoramidase activity
FDZ61_RS01530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FDZ61_RS01545	COG0113	porphobilinogen synthase activity
FDZ61_RS01555	COG0477	Major facilitator Superfamily
FDZ61_RS01590	COG0477	Major facilitator Superfamily
FDZ61_RS01595	COG0477	Major facilitator Superfamily
FDZ61_RS01600	COG0629	single-stranded DNA binding
FDZ61_RS01610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FDZ61_RS01620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FDZ61_RS01645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FDZ61_RS01650	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FDZ61_RS01665	COG0009	L-threonylcarbamoyladenylate synthase
FDZ61_RS01670	COG0237	dephospho-CoA kinase activity
FDZ61_RS01675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FDZ61_RS01680	COG2840	Smr protein MutS2
FDZ61_RS01685	COG1758	RNA polymerase activity
FDZ61_RS01695	COG0495	leucyl-tRNA aminoacylation
FDZ61_RS01705	COG0084	hydrolase, TatD family'
FDZ61_RS01710	COG0284	orotidine-5'-phosphate decarboxylase activity
FDZ61_RS01715	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FDZ61_RS01720	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FDZ61_RS01725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FDZ61_RS01740	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FDZ61_RS01745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FDZ61_RS01750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FDZ61_RS01760	COG0706	membrane insertase activity
FDZ61_RS01765	COG1115	amino acid carrier protein
FDZ61_RS01770	COG1183	phosphatidylcholine synthase activity
FDZ61_RS01775	COG0688	phosphatidylethanolamine metabolic process
FDZ61_RS01780	COG0493	'glutamate synthase
FDZ61_RS01780	COG0543	2 iron, 2 sulfur cluster binding
FDZ61_RS01795	COG0564	pseudouridine synthase activity
FDZ61_RS01805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FDZ61_RS01810	COG2902	Dehydrogenase
FDZ61_RS01815	COG3932	Exopolysaccharide synthesis, ExoD
FDZ61_RS01820	COG0215	cysteine-tRNA ligase activity
FDZ61_RS01830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FDZ61_RS01850	COG0358	DNA primase activity
FDZ61_RS01855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FDZ61_RS01860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FDZ61_RS01865	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FDZ61_RS01890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FDZ61_RS01890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FDZ61_RS01895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FDZ61_RS01920	COG0736	holo-[acyl-carrier-protein] synthase activity
FDZ61_RS01925	COG0442	prolyl-tRNA aminoacylation
FDZ61_RS01940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FDZ61_RS01945	COG0492	ferredoxin-NADP+ reductase activity
FDZ61_RS01950	COG0450	alkyl hydroperoxide reductase
FDZ61_RS01955	COG0436	Aminotransferase
FDZ61_RS01985	COG1185	polyribonucleotide nucleotidyltransferase activity
FDZ61_RS01995	COG0481	GTPase activity
FDZ61_RS02060	COG0154	amidase activity
FDZ61_RS02065	COG0285	dihydrofolate synthase activity
FDZ61_RS02070	COG0181	hydroxymethylbilane synthase activity
FDZ61_RS02085	COG0681	Belongs to the peptidase S26 family
FDZ61_RS02095	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FDZ61_RS02115	COG0137	argininosuccinate synthase activity
FDZ61_RS02135	COG0708	Exodeoxyribonuclease III
FDZ61_RS02170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FDZ61_RS02220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FDZ61_RS02235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FDZ61_RS02240	COG0302	gtp cyclohydrolase
FDZ61_RS02245	COG0312	modulator of DNA gyrase
FDZ61_RS02250	COG0492	ferredoxin-NADP+ reductase activity
FDZ61_RS02255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FDZ61_RS02265	COG0149	triose-phosphate isomerase activity
FDZ61_RS02275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FDZ61_RS02285	COG1714	RDD family
FDZ61_RS02305	COG0698	ribose 5-phosphate isomerase
FDZ61_RS02310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FDZ61_RS02325	COG2945	thiolester hydrolase activity
FDZ61_RS02330	COG1104	cysteine desulfurase activity
FDZ61_RS02335	COG1104	cysteine desulfurase activity
FDZ61_RS02340	COG0822	iron-sulfur transferase activity
FDZ61_RS02345	COG0316	Belongs to the HesB IscA family
FDZ61_RS02350	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FDZ61_RS02355	COG0443	Heat shock 70 kDa protein
FDZ61_RS02370	COG3088	subunit of a heme lyase
FDZ61_RS02375	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FDZ61_RS02395	COG0540	Belongs to the ATCase OTCase family
FDZ61_RS02400	COG0187	DNA topoisomerase II activity
FDZ61_RS02410	COG1034	ATP synthesis coupled electron transport
FDZ61_RS02430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FDZ61_RS02445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FDZ61_RS02465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FDZ61_RS02490	COG0649	NAD binding
FDZ61_RS02495	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FDZ61_RS02500	COG0187	DNA topoisomerase II activity
FDZ61_RS02515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FDZ61_RS02525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FDZ61_RS02530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FDZ61_RS02535	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FDZ61_RS02545	COG1301	dicarboxylic acid transport
FDZ61_RS02560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FDZ61_RS02570	COG3750	Belongs to the UPF0335 family
FDZ61_RS02575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FDZ61_RS02585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FDZ61_RS02630	COG1253	flavin adenine dinucleotide binding
FDZ61_RS02640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FDZ61_RS02650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FDZ61_RS02655	COG0805	protein transport
FDZ61_RS02660	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FDZ61_RS02670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FDZ61_RS02675	COG1007	ATP synthesis coupled electron transport
FDZ61_RS02680	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FDZ61_RS02685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FDZ61_RS02690	COG0713	ATP synthesis coupled electron transport
FDZ61_RS02700	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FDZ61_RS02715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FDZ61_RS02720	COG0148	phosphopyruvate hydratase activity
FDZ61_RS02725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FDZ61_RS02730	COG0275	rRNA processing
FDZ61_RS02735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FDZ61_RS02740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FDZ61_RS02750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FDZ61_RS02755	COG0018	arginyl-trna synthetase
FDZ61_RS02760	COG1381	Involved in DNA repair and RecF pathway recombination
FDZ61_RS02775	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FDZ61_RS02785	COG0606	chelatase, subunit chli
FDZ61_RS02800	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FDZ61_RS02805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FDZ61_RS02825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FDZ61_RS02830	COG0723	plastoquinol--plastocyanin reductase activity
FDZ61_RS02840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FDZ61_RS02850	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FDZ61_RS02860	COG0424	maF-like protein
FDZ61_RS02865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FDZ61_RS02870	COG1566	PFAM secretion protein HlyD family protein
FDZ61_RS02875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FDZ61_RS02885	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FDZ61_RS02890	COG1160	GTP binding
FDZ61_RS02895	COG0505	Belongs to the CarA family
FDZ61_RS02900	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FDZ61_RS02905	COG0756	dUTP diphosphatase activity
FDZ61_RS02920	COG3704	protein secretion by the type IV secretion system
FDZ61_RS02920	COG1340	protein secretion by the type IV secretion system
FDZ61_RS02925	COG3704	protein secretion by the type IV secretion system
FDZ61_RS02930	COG3704	protein secretion by the type IV secretion system
FDZ61_RS02935	COG3451	type IV secretory pathway VirB4
FDZ61_RS02945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FDZ61_RS02950	COG0581	inorganic phosphate transmembrane transporter activity
FDZ61_RS02980	COG4770	biotin carboxylase activity
FDZ61_RS02985	COG0564	pseudouridine synthase activity
FDZ61_RS02990	COG0019	diaminopimelate decarboxylase activity
FDZ61_RS02995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FDZ61_RS03015	COG0006	proline dipeptidase activity
FDZ61_RS03020	COG3577	Aspartyl protease
FDZ61_RS03030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FDZ61_RS03035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FDZ61_RS03060	COG2867	negative regulation of translational initiation
FDZ61_RS03070	COG0443	Heat shock 70 kDa protein
FDZ61_RS03075	COG1530	ribonuclease E activity
FDZ61_RS03090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FDZ61_RS03090	COG2111	Na H antiporter
FDZ61_RS03120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FDZ61_RS03130	COG2885	chlorophyll binding
FDZ61_RS03135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FDZ61_RS03140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FDZ61_RS03145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FDZ61_RS03170	COG0590	tRNA wobble adenosine to inosine editing
FDZ61_RS03175	COG0590	tRNA wobble adenosine to inosine editing
FDZ61_RS03190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FDZ61_RS03205	COG0343	queuine tRNA-ribosyltransferase activity
FDZ61_RS03220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FDZ61_RS03225	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FDZ61_RS03240	COG1115	amino acid carrier protein
FDZ61_RS03245	COG2333	competence protein COMEC
FDZ61_RS03245	COG0658	competence protein
FDZ61_RS03250	COG0072	phenylalanine-tRNA ligase activity
FDZ61_RS03250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FDZ61_RS03260	COG0202	RNA polymerase activity
FDZ61_RS03280	COG0201	protein transport
FDZ61_RS03285	COG0200	Binds to the 23S rRNA
FDZ61_RS03300	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FDZ61_RS03315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FDZ61_RS03345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FDZ61_RS03355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FDZ61_RS03370	COG0088	Forms part of the polypeptide exit tunnel
FDZ61_RS03375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FDZ61_RS03380	COG0051	transcription antitermination factor activity, RNA binding
FDZ61_RS03400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FDZ61_RS03410	COG0539	negative regulation of cytoplasmic translation
FDZ61_RS03415	COG0616	signal peptide processing
FDZ61_RS03420	COG0776	regulation of translation
FDZ61_RS03440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FDZ61_RS03475	COG1074	ATP-dependent DNA helicase activity
FDZ61_RS03490	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FDZ61_RS03495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FDZ61_RS03505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FDZ61_RS03515	COG0114	fumarate hydratase activity
FDZ61_RS03525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FDZ61_RS03535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FDZ61_RS03540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FDZ61_RS03550	COG0542	response to heat
FDZ61_RS03555	COG4221	oxidoreductase activity
FDZ61_RS03560	COG0459	protein refolding
FDZ61_RS03565	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FDZ61_RS03570	COG2003	Belongs to the UPF0758 family
FDZ61_RS03575	COG0047	phosphoribosylformylglycinamidine synthase activity
FDZ61_RS03580	COG0445	tRNA wobble uridine modification
FDZ61_RS03585	COG1494	fructose-1,6-bisphosphatase
FDZ61_RS03605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FDZ61_RS03615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FDZ61_RS03620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FDZ61_RS03630	COG4783	chaperone-mediated protein folding
FDZ61_RS03635	COG0799	negative regulation of ribosome biogenesis
FDZ61_RS03650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FDZ61_RS03655	COG4974	Belongs to the 'phage' integrase family
FDZ61_RS03660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FDZ61_RS03665	COG2204	response regulator
FDZ61_RS03670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FDZ61_RS03690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FDZ61_RS03710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FDZ61_RS03710	COG0574	Belongs to the PEP-utilizing enzyme family
FDZ61_RS03715	COG0651	ATP synthesis coupled electron transport
FDZ61_RS03725	COG3474	cytochrome
FDZ61_RS03735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FDZ61_RS03745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FDZ61_RS03750	COG0632	four-way junction helicase activity
FDZ61_RS03765	COG2814	Major facilitator Superfamily
FDZ61_RS03780	COG1053	succinate dehydrogenase
FDZ61_RS03785	COG1132	(ABC) transporter
FDZ61_RS03815	COG1286	toxin biosynthetic process
FDZ61_RS03825	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FDZ61_RS03830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FDZ61_RS03840	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FDZ61_RS03845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FDZ61_RS03850	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FDZ61_RS03860	COG1278	Cold shock
FDZ61_RS03870	COG0717	Belongs to the dCTP deaminase family
FDZ61_RS03875	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FDZ61_RS03880	COG0124	histidyl-tRNA synthetase
FDZ61_RS03900	COG1612	heme a metabolic process
FDZ61_RS03905	COG4133	protoheme IX ABC transporter activity
FDZ61_RS03970	COG2094	Belongs to the DNA glycosylase MPG family
FDZ61_RS04010	COG0233	cytoplasmic translational termination
FDZ61_RS04040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FDZ61_RS04110	COG0612	Peptidase, M16
FDZ61_RS04115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FDZ61_RS04120	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FDZ61_RS04140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FDZ61_RS04155	COG0516	GMP reductase activity
FDZ61_RS04155	COG0517	IMP dehydrogenase activity
FDZ61_RS04170	COG0596	Alpha beta hydrolase
FDZ61_RS04175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FDZ61_RS04185	COG3118	belongs to the thioredoxin family
FDZ61_RS04190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FDZ61_RS04215	COG0116	Belongs to the methyltransferase superfamily
FDZ61_RS04215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FDZ61_RS04235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FDZ61_RS04245	COG2022	thiamine diphosphate biosynthetic process
FDZ61_RS04260	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FDZ61_RS04270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FDZ61_RS04275	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FDZ61_RS04280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FDZ61_RS04295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FDZ61_RS04300	COG0527	aspartate kinase activity
FDZ61_RS04305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FDZ61_RS04310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FDZ61_RS04315	COG0109	protoheme IX farnesyltransferase activity
FDZ61_RS04320	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FDZ61_RS04330	COG1862	Preprotein translocase
FDZ61_RS04345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FDZ61_RS04360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FDZ61_RS04370	COG0745	RESPONSE REGULATOR receiver
FDZ61_RS04385	COG0489	protein tyrosine kinase activity
FDZ61_RS04390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FDZ61_RS04395	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FDZ61_RS04400	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FDZ61_RS04410	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FDZ61_RS04430	COG3451	type IV secretory pathway VirB4
FDZ61_RS04460	COG0330	HflC and HflK could
FDZ61_RS04465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FDZ61_RS04475	COG0571	ribonuclease III activity
FDZ61_RS04480	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FDZ61_RS04485	COG0612	Peptidase, M16
FDZ61_RS04490	COG0612	Peptidase, M16
FDZ61_RS04500	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FDZ61_RS04505	COG0196	riboflavin kinase activity
FDZ61_RS04510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FDZ61_RS04515	COG2890	protein-(glutamine-N5) methyltransferase activity
FDZ61_RS04520	COG0024	Methionine aminopeptidase
FDZ61_RS04540	COG0508	dehydrogenase complex catalyzes the overall conversion of
FDZ61_RS04555	COG4232	protein-disulfide reductase activity
FDZ61_RS04565	COG0750	zinc metalloprotease
FDZ61_RS04570	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FDZ61_RS04580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FDZ61_RS04585	COG0138	bifunctional purine biosynthesis protein purh
FDZ61_RS04590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FDZ61_RS04595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FDZ61_RS04600	COG3346	SURF1 family
FDZ61_RS04615	COG0371	Dehydrogenase
FDZ61_RS04625	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FDZ61_RS04630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FDZ61_RS04640	COG0849	cell division
FDZ61_RS04645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FDZ61_RS04660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FDZ61_RS04665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FDZ61_RS04680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FDZ61_RS04685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FDZ61_RS04690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FDZ61_RS04700	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FDZ61_RS04705	COG0552	protein localization to endoplasmic reticulum
FDZ61_RS04710	COG0473	3-isopropylmalate dehydrogenase activity
FDZ61_RS04715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FDZ61_RS04720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FDZ61_RS04720	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FDZ61_RS04725	COG0617	tRNA 3'-terminal CCA addition
FDZ61_RS04730	COG0105	UTP biosynthetic process
FDZ61_RS04735	COG1396	sequence-specific DNA binding
FDZ61_RS04850	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FDZ61_RS04860	COG1475	DNA binding
FDZ61_RS04870	COG0336	Belongs to the RNA methyltransferase TrmD family
FDZ61_RS04875	COG0335	large ribosomal subunit rRNA binding
FDZ61_RS04880	COG1058	Belongs to the CinA family
FDZ61_RS04880	COG1546	Belongs to the CinA family
FDZ61_RS04885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FDZ61_RS04895	COG0802	atpase or kinase
FDZ61_RS04900	COG0670	Belongs to the BI1 family