locus-tag	class	description
ERWE_RS00010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ERWE_RS00015	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ERWE_RS00020	COG1845	cytochrome c oxidase, subunit III
ERWE_RS00025	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ERWE_RS00030	COG1253	flavin adenine dinucleotide binding
ERWE_RS00040	COG4695	Portal protein
ERWE_RS00045	COG1073	alpha beta
ERWE_RS00045	COG2226	methyltransferase
ERWE_RS00050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ERWE_RS00055	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ERWE_RS00070	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ERWE_RS00075	COG2948	multi-organism process
ERWE_RS00090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ERWE_RS00090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ERWE_RS00100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ERWE_RS00120	COG0126	phosphoglycerate kinase activity
ERWE_RS00130	COG1570	exodeoxyribonuclease VII activity
ERWE_RS00135	COG1570	exodeoxyribonuclease VII activity
ERWE_RS00150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ERWE_RS00155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ERWE_RS00160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ERWE_RS00200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ERWE_RS00200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ERWE_RS00210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ERWE_RS00225	COG1573	uracil-dna glycosylase
ERWE_RS00230	COG0242	peptide deformylase activity
ERWE_RS00240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ERWE_RS00245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ERWE_RS00260	COG0142	geranyltranstransferase activity
ERWE_RS00265	COG0174	glutamine synthetase
ERWE_RS00275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ERWE_RS00280	COG0156	8-amino-7-oxononanoate synthase activity
ERWE_RS00285	COG0792	nuclease activity
ERWE_RS00305	COG1830	Aldolase
ERWE_RS00315	COG0508	dehydrogenase complex catalyzes the overall conversion of
ERWE_RS00350	COG0519	Catalyzes the synthesis of GMP from XMP
ERWE_RS00355	COG0372	Belongs to the citrate synthase family
ERWE_RS00365	COG0525	valine-tRNA ligase activity
ERWE_RS00375	COG0525	valine-tRNA ligase activity
ERWE_RS00380	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ERWE_RS00390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ERWE_RS00430	COG1138	Cytochrome C-type biogenesis protein
ERWE_RS00440	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ERWE_RS00445	COG0193	aminoacyl-tRNA hydrolase activity
ERWE_RS00460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ERWE_RS00475	COG1981	membrane
ERWE_RS00480	COG0022	dehydrogenase e1 component
ERWE_RS00480	COG0508	dehydrogenase complex catalyzes the overall conversion of
ERWE_RS00495	COG0312	modulator of DNA gyrase
ERWE_RS00500	COG0012	GTP binding
ERWE_RS00505	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ERWE_RS00510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ERWE_RS00510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ERWE_RS00525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ERWE_RS00535	COG0776	regulation of translation
ERWE_RS00565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ERWE_RS00570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ERWE_RS00570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ERWE_RS00580	COG0504	CTP synthase activity
ERWE_RS00590	COG4974	Belongs to the 'phage' integrase family
ERWE_RS00600	COG0280	phosphate acetyltransferase
ERWE_RS00600	COG0281	malic enzyme
ERWE_RS00610	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ERWE_RS00615	COG0651	ATP synthesis coupled electron transport
ERWE_RS00655	COG1840	ABC-type Fe3 transport system, periplasmic component
ERWE_RS00660	COG0228	four-way junction DNA binding
ERWE_RS00665	COG0477	Major facilitator Superfamily
ERWE_RS00695	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ERWE_RS00705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ERWE_RS00730	COG0321	lipoyl(octanoyl) transferase activity
ERWE_RS00730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ERWE_RS00740	COG0573	inorganic phosphate transmembrane transporter activity
ERWE_RS00745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ERWE_RS00750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ERWE_RS00755	COG0045	succinate-CoA ligase (ADP-forming) activity
ERWE_RS00760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ERWE_RS00765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ERWE_RS00780	COG3038	cytochrome b561
ERWE_RS00785	COG1178	ABC-type Fe3 transport system permease component
ERWE_RS00790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ERWE_RS00820	COG0049	tRNA binding
ERWE_RS00855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ERWE_RS00865	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ERWE_RS00870	COG0222	ribosome binding
ERWE_RS00875	COG0085	RNA polymerase activity
ERWE_RS00880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ERWE_RS00885	COG0156	8-amino-7-oxononanoate synthase activity
ERWE_RS00920	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ERWE_RS00925	COG0167	dihydroorotate dehydrogenase activity
ERWE_RS00930	COG0242	peptide deformylase activity
ERWE_RS00935	COG0165	Argininosuccinate lyase
ERWE_RS00950	COG0271	Belongs to the BolA IbaG family
ERWE_RS00965	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ERWE_RS00980	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ERWE_RS00990	COG0351	phosphomethylpyrimidine kinase
ERWE_RS00990	COG0352	thiamine-phosphate diphosphorylase activity
ERWE_RS01000	COG0628	permease
ERWE_RS01010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ERWE_RS01030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ERWE_RS01045	COG0544	peptidyl-prolyl cis-trans isomerase activity
ERWE_RS01050	COG0740	serine-type endopeptidase activity
ERWE_RS01060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ERWE_RS01070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ERWE_RS01080	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ERWE_RS01085	COG0352	thiamine-phosphate diphosphorylase activity
ERWE_RS01090	COG4536	flavin adenine dinucleotide binding
ERWE_RS01100	COG1674	ftsk spoiiie
ERWE_RS01110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ERWE_RS01115	COG2202	Pas domain
ERWE_RS01115	COG2205	protein histidine kinase activity
ERWE_RS01120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ERWE_RS01125	COG0758	DNA mediated transformation
ERWE_RS01130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ERWE_RS01135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ERWE_RS01165	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ERWE_RS01170	COG0482	sulfurtransferase activity
ERWE_RS01265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ERWE_RS01270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ERWE_RS01280	COG0326	Molecular chaperone. Has ATPase activity
ERWE_RS01285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ERWE_RS01325	COG0625	glutathione transferase activity
ERWE_RS01335	COG3842	ATPase activity
ERWE_RS01340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ERWE_RS01345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ERWE_RS01360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ERWE_RS01370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ERWE_RS01400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ERWE_RS01405	COG0537	adenosine 5'-monophosphoramidase activity
ERWE_RS01415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ERWE_RS01420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ERWE_RS01430	COG0113	porphobilinogen synthase activity
ERWE_RS01440	COG0477	Major facilitator Superfamily
ERWE_RS01480	COG0477	Major facilitator Superfamily
ERWE_RS01485	COG0477	Major facilitator Superfamily
ERWE_RS01490	COG0629	single-stranded DNA binding
ERWE_RS01500	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ERWE_RS01510	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ERWE_RS01535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ERWE_RS01540	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ERWE_RS01550	COG0470	DNA polymerase III
ERWE_RS01555	COG0009	L-threonylcarbamoyladenylate synthase
ERWE_RS01560	COG0237	dephospho-CoA kinase activity
ERWE_RS01565	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ERWE_RS01570	COG2840	Smr protein MutS2
ERWE_RS01575	COG1758	RNA polymerase activity
ERWE_RS01585	COG0495	leucyl-tRNA aminoacylation
ERWE_RS01590	COG0084	hydrolase, TatD family'
ERWE_RS01595	COG0284	orotidine-5'-phosphate decarboxylase activity
ERWE_RS01600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ERWE_RS01605	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ERWE_RS01610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ERWE_RS01615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ERWE_RS01625	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ERWE_RS01630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ERWE_RS01635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ERWE_RS01645	COG0706	membrane insertase activity
ERWE_RS01650	COG1115	amino acid carrier protein
ERWE_RS01655	COG1183	phosphatidylcholine synthase activity
ERWE_RS01660	COG0688	phosphatidylethanolamine metabolic process
ERWE_RS01665	COG0493	'glutamate synthase
ERWE_RS01665	COG0543	2 iron, 2 sulfur cluster binding
ERWE_RS01680	COG0564	pseudouridine synthase activity
ERWE_RS01690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ERWE_RS01695	COG2902	Dehydrogenase
ERWE_RS01700	COG3932	Exopolysaccharide synthesis, ExoD
ERWE_RS01705	COG0215	cysteine-tRNA ligase activity
ERWE_RS01715	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ERWE_RS01735	COG0358	DNA primase activity
ERWE_RS01740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ERWE_RS01745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ERWE_RS01750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ERWE_RS01775	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ERWE_RS01775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ERWE_RS01780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ERWE_RS01800	COG0736	holo-[acyl-carrier-protein] synthase activity
ERWE_RS01805	COG0442	prolyl-tRNA aminoacylation
ERWE_RS01820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ERWE_RS01825	COG0492	ferredoxin-NADP+ reductase activity
ERWE_RS01830	COG0450	alkyl hydroperoxide reductase
ERWE_RS01835	COG0436	Aminotransferase
ERWE_RS01865	COG1185	polyribonucleotide nucleotidyltransferase activity
ERWE_RS01875	COG0481	GTPase activity
ERWE_RS01925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ERWE_RS01935	COG0154	amidase activity
ERWE_RS01940	COG0285	dihydrofolate synthase activity
ERWE_RS01945	COG0181	hydroxymethylbilane synthase activity
ERWE_RS01950	COG1217	gtp-binding protein TYPA
ERWE_RS01965	COG0681	Belongs to the peptidase S26 family
ERWE_RS01975	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ERWE_RS01995	COG0137	argininosuccinate synthase activity
ERWE_RS02015	COG0708	Exodeoxyribonuclease III
ERWE_RS02050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ERWE_RS02100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ERWE_RS02115	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ERWE_RS02120	COG0302	gtp cyclohydrolase
ERWE_RS02125	COG0312	modulator of DNA gyrase
ERWE_RS02130	COG0492	ferredoxin-NADP+ reductase activity
ERWE_RS02135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ERWE_RS02145	COG0149	triose-phosphate isomerase activity
ERWE_RS02155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ERWE_RS02165	COG1714	RDD family
ERWE_RS02185	COG0698	ribose 5-phosphate isomerase
ERWE_RS02190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ERWE_RS02195	COG1959	2 iron, 2 sulfur cluster binding
ERWE_RS02200	COG2945	thiolester hydrolase activity
ERWE_RS02205	COG1104	cysteine desulfurase activity
ERWE_RS02210	COG1104	cysteine desulfurase activity
ERWE_RS02215	COG0822	iron-sulfur transferase activity
ERWE_RS02220	COG0316	Belongs to the HesB IscA family
ERWE_RS02225	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ERWE_RS02230	COG0443	Heat shock 70 kDa protein
ERWE_RS02245	COG3088	subunit of a heme lyase
ERWE_RS02250	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ERWE_RS02260	COG0101	tRNA pseudouridine synthase activity
ERWE_RS02265	COG0540	Belongs to the ATCase OTCase family
ERWE_RS02270	COG0187	DNA topoisomerase II activity
ERWE_RS02280	COG1034	ATP synthesis coupled electron transport
ERWE_RS02300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ERWE_RS02320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ERWE_RS02340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ERWE_RS02365	COG0649	NAD binding
ERWE_RS02370	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ERWE_RS02385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ERWE_RS02395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ERWE_RS02400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ERWE_RS02405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ERWE_RS02415	COG1301	dicarboxylic acid transport
ERWE_RS02430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ERWE_RS02440	COG3750	Belongs to the UPF0335 family
ERWE_RS02445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ERWE_RS02455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ERWE_RS02500	COG1253	flavin adenine dinucleotide binding
ERWE_RS02510	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ERWE_RS02520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ERWE_RS02525	COG0805	protein transport
ERWE_RS02530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ERWE_RS02540	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ERWE_RS02545	COG1007	ATP synthesis coupled electron transport
ERWE_RS02550	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ERWE_RS02555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ERWE_RS02560	COG0713	ATP synthesis coupled electron transport
ERWE_RS02570	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ERWE_RS02585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ERWE_RS02590	COG0148	phosphopyruvate hydratase activity
ERWE_RS02595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ERWE_RS02600	COG0275	rRNA processing
ERWE_RS02605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ERWE_RS02610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ERWE_RS02620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ERWE_RS02625	COG0018	arginyl-trna synthetase
ERWE_RS02630	COG1381	Involved in DNA repair and RecF pathway recombination
ERWE_RS02645	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ERWE_RS02650	COG0606	chelatase, subunit chli
ERWE_RS02665	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ERWE_RS02670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ERWE_RS02690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ERWE_RS02695	COG0723	plastoquinol--plastocyanin reductase activity
ERWE_RS02705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ERWE_RS02715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ERWE_RS02725	COG0424	maF-like protein
ERWE_RS02730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ERWE_RS02735	COG1566	PFAM secretion protein HlyD family protein
ERWE_RS02740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ERWE_RS02750	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ERWE_RS02755	COG1160	GTP binding
ERWE_RS02765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ERWE_RS02770	COG0756	dUTP diphosphatase activity
ERWE_RS02790	COG3704	protein secretion by the type IV secretion system
ERWE_RS02790	COG1340	protein secretion by the type IV secretion system
ERWE_RS02795	COG3704	protein secretion by the type IV secretion system
ERWE_RS02800	COG3704	protein secretion by the type IV secretion system
ERWE_RS02805	COG3451	type IV secretory pathway VirB4
ERWE_RS02815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ERWE_RS02820	COG0581	inorganic phosphate transmembrane transporter activity
ERWE_RS02845	COG4770	biotin carboxylase activity
ERWE_RS02850	COG0564	pseudouridine synthase activity
ERWE_RS02855	COG0019	diaminopimelate decarboxylase activity
ERWE_RS02860	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ERWE_RS02880	COG0006	proline dipeptidase activity
ERWE_RS02885	COG3577	Aspartyl protease
ERWE_RS02895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ERWE_RS02900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ERWE_RS02935	COG2867	negative regulation of translational initiation
ERWE_RS02940	COG0443	Heat shock 70 kDa protein
ERWE_RS02945	COG1530	ribonuclease E activity
ERWE_RS02960	COG2111	Na H antiporter
ERWE_RS02960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ERWE_RS02990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ERWE_RS03000	COG2885	chlorophyll binding
ERWE_RS03005	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ERWE_RS03010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ERWE_RS03015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ERWE_RS03040	COG0590	tRNA wobble adenosine to inosine editing
ERWE_RS03045	COG0590	tRNA wobble adenosine to inosine editing
ERWE_RS03060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ERWE_RS03075	COG0343	queuine tRNA-ribosyltransferase activity
ERWE_RS03090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ERWE_RS03095	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ERWE_RS03105	COG1115	amino acid carrier protein
ERWE_RS03110	COG2333	competence protein COMEC
ERWE_RS03110	COG0658	competence protein
ERWE_RS03115	COG0072	phenylalanine-tRNA ligase activity
ERWE_RS03115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ERWE_RS03125	COG0202	RNA polymerase activity
ERWE_RS03145	COG0201	protein transport
ERWE_RS03150	COG0200	Binds to the 23S rRNA
ERWE_RS03165	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ERWE_RS03180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ERWE_RS03210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ERWE_RS03220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ERWE_RS03235	COG0088	Forms part of the polypeptide exit tunnel
ERWE_RS03240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ERWE_RS03245	COG0051	transcription antitermination factor activity, RNA binding
ERWE_RS03265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ERWE_RS03275	COG0539	negative regulation of cytoplasmic translation
ERWE_RS03280	COG0616	signal peptide processing
ERWE_RS03285	COG0776	regulation of translation
ERWE_RS03305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ERWE_RS03340	COG1074	ATP-dependent DNA helicase activity
ERWE_RS03355	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ERWE_RS03360	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ERWE_RS03370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ERWE_RS03380	COG0114	fumarate hydratase activity
ERWE_RS03390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ERWE_RS03400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ERWE_RS03405	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ERWE_RS03415	COG0542	response to heat
ERWE_RS03420	COG4221	oxidoreductase activity
ERWE_RS03425	COG0459	protein refolding
ERWE_RS03430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ERWE_RS03435	COG2003	Belongs to the UPF0758 family
ERWE_RS03440	COG0047	phosphoribosylformylglycinamidine synthase activity
ERWE_RS03445	COG0445	tRNA wobble uridine modification
ERWE_RS03450	COG1494	fructose-1,6-bisphosphatase
ERWE_RS03470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ERWE_RS03475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ERWE_RS03480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ERWE_RS03490	COG4783	chaperone-mediated protein folding
ERWE_RS03495	COG0799	negative regulation of ribosome biogenesis
ERWE_RS03510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ERWE_RS03515	COG4974	Belongs to the 'phage' integrase family
ERWE_RS03520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ERWE_RS03525	COG2204	response regulator
ERWE_RS03530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ERWE_RS03535	COG2204	response regulator
ERWE_RS03550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ERWE_RS03565	COG0574	Belongs to the PEP-utilizing enzyme family
ERWE_RS03565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ERWE_RS03570	COG0651	ATP synthesis coupled electron transport
ERWE_RS03580	COG3474	cytochrome
ERWE_RS03590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ERWE_RS03600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ERWE_RS03605	COG0632	four-way junction helicase activity
ERWE_RS03620	COG2814	Major facilitator Superfamily
ERWE_RS03625	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ERWE_RS03635	COG1053	succinate dehydrogenase
ERWE_RS03640	COG1132	(ABC) transporter
ERWE_RS03670	COG1286	toxin biosynthetic process
ERWE_RS03680	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ERWE_RS03685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ERWE_RS03695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ERWE_RS03700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ERWE_RS03705	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ERWE_RS03715	COG1278	Cold shock
ERWE_RS03725	COG0717	Belongs to the dCTP deaminase family
ERWE_RS03730	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ERWE_RS03735	COG0124	histidyl-tRNA synthetase
ERWE_RS03750	COG1612	heme a metabolic process
ERWE_RS03755	COG4133	protoheme IX ABC transporter activity
ERWE_RS03820	COG2094	Belongs to the DNA glycosylase MPG family
ERWE_RS03850	COG0233	cytoplasmic translational termination
ERWE_RS03880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ERWE_RS03945	COG0612	Peptidase, M16
ERWE_RS03950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ERWE_RS03955	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ERWE_RS03975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ERWE_RS03990	COG0516	GMP reductase activity
ERWE_RS03990	COG0517	IMP dehydrogenase activity
ERWE_RS04005	COG0596	Alpha beta hydrolase
ERWE_RS04010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ERWE_RS04020	COG3118	belongs to the thioredoxin family
ERWE_RS04025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ERWE_RS04050	COG0116	Belongs to the methyltransferase superfamily
ERWE_RS04050	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ERWE_RS04065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ERWE_RS04070	COG2022	thiamine diphosphate biosynthetic process
ERWE_RS04085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ERWE_RS04095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ERWE_RS04100	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ERWE_RS04105	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ERWE_RS04120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ERWE_RS04125	COG0527	aspartate kinase activity
ERWE_RS04130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ERWE_RS04135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ERWE_RS04140	COG0109	protoheme IX farnesyltransferase activity
ERWE_RS04145	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ERWE_RS04155	COG1862	Preprotein translocase
ERWE_RS04170	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ERWE_RS04185	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ERWE_RS04195	COG0745	RESPONSE REGULATOR receiver
ERWE_RS04210	COG0489	protein tyrosine kinase activity
ERWE_RS04215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ERWE_RS04220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ERWE_RS04225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ERWE_RS04235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ERWE_RS04255	COG3451	type IV secretory pathway VirB4
ERWE_RS04285	COG0330	HflC and HflK could
ERWE_RS04290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ERWE_RS04300	COG0571	ribonuclease III activity
ERWE_RS04305	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ERWE_RS04310	COG0612	Peptidase, M16
ERWE_RS04315	COG0612	Peptidase, M16
ERWE_RS04330	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ERWE_RS04335	COG0196	riboflavin kinase activity
ERWE_RS04340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ERWE_RS04345	COG2890	protein-(glutamine-N5) methyltransferase activity
ERWE_RS04350	COG0024	Methionine aminopeptidase
ERWE_RS04355	COG0024	Methionine aminopeptidase
ERWE_RS04375	COG0508	dehydrogenase complex catalyzes the overall conversion of
ERWE_RS04385	COG1686	Belongs to the peptidase S11 family
ERWE_RS04390	COG4232	protein-disulfide reductase activity
ERWE_RS04400	COG0750	zinc metalloprotease
ERWE_RS04405	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ERWE_RS04415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ERWE_RS04420	COG0138	bifunctional purine biosynthesis protein purh
ERWE_RS04425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ERWE_RS04430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ERWE_RS04435	COG3346	SURF1 family
ERWE_RS04455	COG0371	Dehydrogenase
ERWE_RS04470	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ERWE_RS04475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ERWE_RS04485	COG0849	cell division
ERWE_RS04490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ERWE_RS04505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ERWE_RS04510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ERWE_RS04520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ERWE_RS04525	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ERWE_RS04530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ERWE_RS04540	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ERWE_RS04545	COG0552	protein localization to endoplasmic reticulum
ERWE_RS04550	COG0473	3-isopropylmalate dehydrogenase activity
ERWE_RS04555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ERWE_RS04560	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ERWE_RS04560	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ERWE_RS04565	COG0617	tRNA 3'-terminal CCA addition
ERWE_RS04570	COG0105	UTP biosynthetic process
ERWE_RS04575	COG1396	sequence-specific DNA binding
ERWE_RS04695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ERWE_RS04705	COG1475	DNA binding
ERWE_RS04715	COG0336	Belongs to the RNA methyltransferase TrmD family
ERWE_RS04720	COG0335	large ribosomal subunit rRNA binding
ERWE_RS04725	COG1546	Belongs to the CinA family
ERWE_RS04725	COG1058	Belongs to the CinA family
ERWE_RS04730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ERWE_RS04740	COG0802	atpase or kinase
ERWE_RS04745	COG0670	Belongs to the BI1 family
ERWE_RS04755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ERWE_RS04760	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ERWE_RS04770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ERWE_RS04780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ERWE_RS04785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ERWE_RS04795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ERWE_RS04810	COG0752	glycyl-tRNA synthetase alpha subunit
ERWE_RS04815	COG0751	glycine-tRNA ligase activity
ERWE_RS04820	COG0484	heat shock protein binding