locus-tag	class	description
AL492_RS00035	COG0542	response to heat
AL492_RS00105	COG2197	response regulator
AL492_RS00110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AL492_RS00170	COG0739	heme binding
AL492_RS00230	COG0484	heat shock protein binding
AL492_RS00270	COG2259	Doxx family
AL492_RS00335	COG0629	single-stranded DNA binding
AL492_RS00415	COG4206	TonB-dependent receptor
AL492_RS00415	COG1629	transport
AL492_RS00465	COG1505	serine-type exopeptidase activity
AL492_RS00490	COG0681	Belongs to the peptidase S26 family
AL492_RS00500	COG4974	Belongs to the 'phage' integrase family
AL492_RS00525	COG1104	cysteine desulfurase activity
AL492_RS00535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL492_RS00540	COG2885	chlorophyll binding
AL492_RS00560	COG0681	Belongs to the peptidase S26 family
AL492_RS00565	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL492_RS00575	COG1475	DNA binding
AL492_RS00580	COG1192	Involved in chromosome partitioning
AL492_RS00590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL492_RS00595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL492_RS00610	COG0306	phosphate transporter
AL492_RS00625	COG0084	hydrolase, TatD family'
AL492_RS00630	COG0513	Belongs to the DEAD box helicase family
AL492_RS00635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL492_RS00640	COG0563	adenylate kinase activity
AL492_RS00645	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AL492_RS00670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL492_RS00680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL492_RS00685	COG2011	ABC-type metal ion transport system permease component
AL492_RS00690	COG1464	Belongs to the NlpA lipoprotein family
AL492_RS00695	COG4677	pectinesterase activity
AL492_RS00700	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AL492_RS00725	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL492_RS00725	COG0463	Glycosyl transferase, family 2
AL492_RS00730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL492_RS00730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL492_RS00745	COG3345	alpha-galactosidase
AL492_RS00775	COG1335	isochorismatase
AL492_RS00810	COG1418	mRNA catabolic process
AL492_RS00825	COG2226	methyltransferase
AL492_RS00835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL492_RS00850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL492_RS00855	COG0405	Gamma-glutamyltransferase
AL492_RS00870	COG4574	serine-type endopeptidase inhibitor activity
AL492_RS00880	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AL492_RS00895	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL492_RS00915	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL492_RS00935	COG0592	DNA-directed DNA polymerase activity
AL492_RS00950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL492_RS00970	COG1702	phosphate starvation-inducible protein PhoH
AL492_RS00985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL492_RS01020	COG1741	Belongs to the pirin family
AL492_RS01025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL492_RS01030	COG0477	Major facilitator Superfamily
AL492_RS01035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL492_RS01040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL492_RS01045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL492_RS01050	COG0131	Imidazoleglycerol-phosphate dehydratase
AL492_RS01070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL492_RS01080	COG0107	imidazoleglycerol-phosphate synthase activity
AL492_RS01085	COG0140	phosphoribosyl-ATP diphosphatase activity
AL492_RS01085	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL492_RS01115	COG0730	response to heat
AL492_RS01125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AL492_RS01140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL492_RS01140	COG2169	Transcriptional regulator
AL492_RS01165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL492_RS01170	COG3384	dioxygenase
AL492_RS01175	COG2353	YceI-like domain
AL492_RS01195	COG2814	Major facilitator Superfamily
AL492_RS01200	COG3781	membrane
AL492_RS01210	COG2378	regulation of single-species biofilm formation
AL492_RS01220	COG0612	Peptidase, M16
AL492_RS01225	COG0612	Peptidase, M16
AL492_RS01230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL492_RS01235	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AL492_RS01285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL492_RS01300	COG1194	a g-specific adenine glycosylase
AL492_RS01305	COG0776	regulation of translation
AL492_RS01310	COG1530	ribonuclease E activity
AL492_RS01325	COG2268	Band 7 protein
AL492_RS01335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL492_RS01350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL492_RS01360	COG0427	acetyl-CoA hydrolase
AL492_RS01365	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AL492_RS01390	COG2234	aminopeptidase activity
AL492_RS01400	COG3590	peptidase
AL492_RS01415	COG3590	peptidase
AL492_RS01425	COG1546	Belongs to the CinA family
AL492_RS01425	COG1058	Belongs to the CinA family
AL492_RS01455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL492_RS01470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL492_RS01485	COG0596	Alpha beta hydrolase
AL492_RS01515	COG5002	protein histidine kinase activity
AL492_RS01520	COG0745	RESPONSE REGULATOR receiver
AL492_RS01535	COG2732	(Barnase) inhibitor
AL492_RS01545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL492_RS01565	COG0626	cystathionine gamma-synthase activity
AL492_RS01570	COG0009	L-threonylcarbamoyladenylate synthase
AL492_RS01575	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AL492_RS01575	COG0617	tRNA 3'-terminal CCA addition
AL492_RS01575	COG0517	IMP dehydrogenase activity
AL492_RS01580	COG3361	conserved protein (COG2071)
AL492_RS01585	COG4771	TonB-dependent receptor
AL492_RS01590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL492_RS01595	COG3104	oligopeptide transport
AL492_RS01600	COG3104	oligopeptide transport
AL492_RS01610	COG1506	peptidase
AL492_RS01610	COG0823	Involved in the tonB-independent uptake of proteins
AL492_RS01645	COG2755	lipolytic protein G-D-S-L family
AL492_RS01660	COG1446	asparaginase
AL492_RS01675	COG1566	PFAM secretion protein HlyD family protein
AL492_RS01685	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AL492_RS01705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL492_RS01730	COG2017	converts alpha-aldose to the beta-anomer
AL492_RS01735	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AL492_RS01740	COG1085	galactose-1-phosphate uridylyltransferase
AL492_RS01745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL492_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
AL492_RS01765	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AL492_RS01770	COG2271	Major facilitator Superfamily
AL492_RS01780	COG0579	oxidoreductase
AL492_RS01785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL492_RS01790	COG0739	heme binding
AL492_RS01800	COG2264	protein methyltransferase activity
AL492_RS01805	COG0149	triose-phosphate isomerase activity
AL492_RS01840	COG1522	sequence-specific DNA binding
AL492_RS01845	COG0697	spore germination
AL492_RS01875	COG0358	DNA primase activity
AL492_RS01880	COG0586	Pfam SNARE associated Golgi protein
AL492_RS01890	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AL492_RS01900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL492_RS01905	COG1131	(ABC) transporter
AL492_RS01915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL492_RS01920	COG0300	oxidoreductase activity
AL492_RS01930	COG2272	Belongs to the type-B carboxylesterase lipase family
AL492_RS01940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL492_RS01965	COG2972	Histidine kinase
AL492_RS01970	COG3279	Response regulator of the LytR AlgR family
AL492_RS01975	COG2217	Heavy metal translocating P-type atpase
AL492_RS01990	COG2204	response regulator
AL492_RS02005	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AL492_RS02015	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AL492_RS02025	COG2205	protein histidine kinase activity
AL492_RS02050	COG4717	serine-type aminopeptidase activity
AL492_RS02055	COG1472	Belongs to the glycosyl hydrolase 3 family
AL492_RS02060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL492_RS02065	COG0612	Peptidase, M16
AL492_RS02070	COG1027	Aspartate ammonia-lyase
AL492_RS02075	COG3023	N-Acetylmuramoyl-L-alanine amidase
AL492_RS02110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL492_RS02120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL492_RS02130	COG1917	Cupin 2, conserved barrel domain protein
AL492_RS02130	COG4977	sequence-specific DNA binding
AL492_RS02150	COG0475	glutathione-regulated potassium exporter activity
AL492_RS02155	COG3279	Response regulator of the LytR AlgR family
AL492_RS02165	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AL492_RS02170	COG0352	thiamine-phosphate diphosphorylase activity
AL492_RS02175	COG0351	phosphomethylpyrimidine kinase
AL492_RS02175	COG0352	thiamine-phosphate diphosphorylase activity
AL492_RS02250	COG1309	transcriptional regulator
AL492_RS02255	COG1309	transcriptional regulator
AL492_RS02275	COG0492	ferredoxin-NADP+ reductase activity
AL492_RS02295	COG1011	Hydrolase
AL492_RS02340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL492_RS02340	COG1333	cytochrome c biogenesis protein
AL492_RS02345	COG1674	ftsk spoiiie
AL492_RS02370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL492_RS02385	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL492_RS02410	COG0492	ferredoxin-NADP+ reductase activity
AL492_RS02420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL492_RS02440	COG2824	Alkylphosphonate utilization operon protein PhnA
AL492_RS02445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL492_RS02445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL492_RS02455	COG0367	asparagine synthase
AL492_RS02470	COG0456	acetyltransferase
AL492_RS02475	COG0402	S-adenosylhomocysteine deaminase activity
AL492_RS02480	COG0666	response to abiotic stimulus
AL492_RS02490	COG0402	S-adenosylhomocysteine deaminase activity
AL492_RS02500	COG4145	pantothenate transmembrane transporter activity
AL492_RS02520	COG3876	Protein conserved in bacteria
AL492_RS02535	COG3118	belongs to the thioredoxin family
AL492_RS02540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL492_RS02555	COG1012	belongs to the aldehyde dehydrogenase family
AL492_RS02565	COG0006	proline dipeptidase activity
AL492_RS02570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL492_RS02610	COG2706	6-phosphogluconolactonase activity
AL492_RS02655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL492_RS02690	COG1349	DNA-binding transcription factor activity
AL492_RS02705	COG0800	Aldolase
AL492_RS02720	COG2610	gluconate transmembrane transporter activity
AL492_RS02730	COG1629	transport
AL492_RS02730	COG4206	TonB-dependent receptor
AL492_RS02750	COG1538	Outer membrane efflux protein
AL492_RS02785	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AL492_RS02790	COG4654	Cytochrome c, class I
AL492_RS02805	COG1959	2 iron, 2 sulfur cluster binding
AL492_RS02810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL492_RS02815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL492_RS02820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL492_RS02825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL492_RS02830	COG0156	8-amino-7-oxononanoate synthase activity
AL492_RS02840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL492_RS02895	COG2807	transmembrane transport
AL492_RS02905	COG2814	Major facilitator Superfamily
AL492_RS02910	COG1733	regulation of RNA biosynthetic process
AL492_RS02935	COG0659	secondary active sulfate transmembrane transporter activity
AL492_RS02970	COG0038	chloride channel
AL492_RS03005	COG1858	cytochrome C peroxidase
AL492_RS03050	COG3541	Predicted nucleotidyltransferase
AL492_RS03070	COG1960	acyl-CoA dehydrogenase activity
AL492_RS03080	COG3655	Transcriptional regulator
AL492_RS03085	COG1131	(ABC) transporter
AL492_RS03130	COG3422	double-strand break repair
AL492_RS03145	COG4585	Histidine kinase
AL492_RS03160	COG0561	phosphatase activity
AL492_RS03165	COG0494	nUDIX hydrolase
AL492_RS03175	COG0183	Belongs to the thiolase family
AL492_RS03190	COG1309	transcriptional regulator
AL492_RS03205	COG2207	Transcriptional regulator
AL492_RS03210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL492_RS03240	COG0038	chloride channel
AL492_RS03245	COG1028	Short-chain dehydrogenase reductase Sdr
AL492_RS03270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL492_RS03275	COG1053	succinate dehydrogenase
AL492_RS03285	COG0471	metal ion transport
AL492_RS03305	COG4716	Myosin-crossreactive antigen
AL492_RS03310	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL492_RS03310	COG1024	Enoyl-CoA hydratase
AL492_RS03320	COG3279	Response regulator of the LytR AlgR family
AL492_RS03350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL492_RS03350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL492_RS03375	COG1876	peptidase activity
AL492_RS03380	COG3621	Patatin-like phospholipase
AL492_RS03465	COG1063	alcohol dehydrogenase
AL492_RS03480	COG4771	TonB-dependent receptor
AL492_RS03505	COG3119	arylsulfatase activity
AL492_RS03510	COG0233	cytoplasmic translational termination
AL492_RS03515	COG0528	UMP kinase activity
AL492_RS03520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL492_RS03545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL492_RS03560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL492_RS03565	COG1253	flavin adenine dinucleotide binding
AL492_RS03575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL492_RS03580	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL492_RS03585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL492_RS03590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL492_RS03595	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL492_RS03600	COG0356	it plays a direct role in the translocation of protons across the membrane
AL492_RS03625	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL492_RS03630	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL492_RS03635	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL492_RS03640	COG0649	NAD binding
AL492_RS03645	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AL492_RS03650	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AL492_RS03660	COG1034	ATP synthesis coupled electron transport
AL492_RS03665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AL492_RS03670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL492_RS03675	COG0839	Belongs to the complex I subunit 6 family
AL492_RS03680	COG0713	ATP synthesis coupled electron transport
AL492_RS03685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL492_RS03690	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL492_RS03695	COG1007	ATP synthesis coupled electron transport
AL492_RS03735	COG2936	dipeptidyl-peptidase activity
AL492_RS03740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AL492_RS03745	COG3956	TIGRFAM MazG family protein
AL492_RS03755	COG0242	peptide deformylase activity
AL492_RS03760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL492_RS03775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AL492_RS03780	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL492_RS03780	COG0284	orotidine-5'-phosphate decarboxylase activity
AL492_RS03835	COG0443	Heat shock 70 kDa protein
AL492_RS03840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL492_RS03845	COG0248	Ppx GppA phosphatase
AL492_RS03850	COG4774	siderophore transport
AL492_RS03855	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL492_RS03860	COG0489	protein tyrosine kinase activity
AL492_RS03890	COG0708	Exodeoxyribonuclease III
AL492_RS03915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL492_RS03935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL492_RS03950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL492_RS03955	COG1794	racemase activity, acting on amino acids and derivatives
AL492_RS03960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL492_RS03970	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AL492_RS04000	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
AL492_RS04005	COG1301	dicarboxylic acid transport
AL492_RS04010	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL492_RS04015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL492_RS04040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL492_RS04045	COG3119	arylsulfatase activity
AL492_RS04055	COG1629	transport
AL492_RS04060	COG0205	6-phosphofructokinase activity
AL492_RS04070	COG4771	TonB-dependent receptor
AL492_RS04075	COG0720	synthase
AL492_RS04080	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL492_RS04095	COG2224	Isocitrate lyase
AL492_RS04100	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL492_RS04105	COG1396	sequence-specific DNA binding
AL492_RS04110	COG1040	competence protein
AL492_RS04115	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL492_RS04125	COG1160	GTP binding
AL492_RS04145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL492_RS04155	COG1704	LemA family
AL492_RS04165	COG0436	Aminotransferase
AL492_RS04175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL492_RS04180	COG0113	porphobilinogen synthase activity
AL492_RS04195	COG1522	sequence-specific DNA binding
AL492_RS04205	COG0336	Belongs to the RNA methyltransferase TrmD family
AL492_RS04220	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
AL492_RS04225	COG0488	(ABC) transporter
AL492_RS04230	COG0813	purine-nucleoside phosphorylase activity
AL492_RS04240	COG0673	inositol 2-dehydrogenase activity
AL492_RS04245	COG4206	TonB-dependent receptor
AL492_RS04255	COG3264	Mechanosensitive ion channel
AL492_RS04255	COG1196	nuclear chromosome segregation
AL492_RS04260	COG0045	succinate-CoA ligase (ADP-forming) activity
AL492_RS04270	COG2363	Small membrane protein
AL492_RS04280	COG0488	(ABC) transporter
AL492_RS04320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL492_RS04335	COG2945	thiolester hydrolase activity
AL492_RS04340	COG3321	synthase
AL492_RS04340	COG1028	Short-chain dehydrogenase reductase Sdr
AL492_RS04340	COG0604	alcohol dehydrogenase
AL492_RS04355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL492_RS04390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL492_RS04400	COG0308	aminopeptidase N
AL492_RS04410	COG0018	arginyl-trna synthetase
AL492_RS04420	COG1629	transport
AL492_RS04430	COG4771	TonB-dependent receptor
AL492_RS04435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL492_RS04445	COG0706	membrane insertase activity
AL492_RS04450	COG0504	CTP synthase activity
AL492_RS04455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL492_RS04475	COG4221	oxidoreductase activity
AL492_RS04505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL492_RS04510	COG0459	protein refolding
AL492_RS04555	COG0494	nUDIX hydrolase
AL492_RS04585	COG2267	carboxylic ester hydrolase activity
AL492_RS04610	COG1881	PFAM PEBP family protein
AL492_RS04615	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL492_RS04660	COG0339	signal peptide processing
AL492_RS04675	COG4628	conserved protein (DUF2132)
AL492_RS04680	COG1047	Peptidyl-prolyl cis-trans
AL492_RS04690	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AL492_RS04700	COG0259	pyridoxamine-phosphate oxidase activity
AL492_RS04705	COG1678	Uncharacterized ACR, COG1678
AL492_RS04725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL492_RS04740	COG3158	transport of potassium into the cell
AL492_RS04745	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL492_RS04745	COG0022	dehydrogenase e1 component
AL492_RS04765	COG1183	phosphatidylcholine synthase activity
AL492_RS04770	COG2176	DNA-directed DNA polymerase activity
AL492_RS04845	COG1733	regulation of RNA biosynthetic process
AL492_RS04850	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL492_RS04855	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL492_RS04855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL492_RS04865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL492_RS04870	COG0514	ATP-dependent DNA helicase (RecQ)
AL492_RS04885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL492_RS04885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL492_RS04890	COG0616	signal peptide processing
AL492_RS04895	COG2261	transglycosylase associated protein
AL492_RS04900	COG0552	protein localization to endoplasmic reticulum
AL492_RS04915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL492_RS04920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL492_RS04940	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL492_RS04945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL492_RS04950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL492_RS04965	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL492_RS04970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL492_RS05010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL492_RS05025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL492_RS05035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL492_RS05045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL492_RS05090	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL492_RS05095	COG0194	GDP metabolic process
AL492_RS05100	COG4106	trans-aconitate 2-methyltransferase activity
AL492_RS05105	COG1561	YicC-like family, N-terminal region
AL492_RS05110	COG1663	tetraacyldisaccharide 4'-kinase activity
AL492_RS05120	COG0222	ribosome binding
AL492_RS05125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL492_RS05130	COG0081	regulation of translation
AL492_RS05135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL492_RS05145	COG1733	regulation of RNA biosynthetic process
AL492_RS05150	COG3047	cAMP biosynthetic process
AL492_RS05170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL492_RS05200	COG4974	Belongs to the 'phage' integrase family
AL492_RS05205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL492_RS05210	COG1074	ATP-dependent DNA helicase activity
AL492_RS05225	COG0322	excinuclease ABC activity
AL492_RS05235	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL492_RS05245	COG0861	Integral membrane protein TerC family
AL492_RS05250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL492_RS05255	COG2986	histidine ammonia-lyase
AL492_RS05260	COG1528	Iron-storage protein
AL492_RS05280	COG1640	4-alpha-glucanotransferase
AL492_RS05285	COG0215	cysteine-tRNA ligase activity
AL492_RS05290	COG0302	gtp cyclohydrolase
AL492_RS05295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL492_RS05300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL492_RS05305	COG0571	ribonuclease III activity
AL492_RS05320	COG1115	amino acid carrier protein
AL492_RS05325	COG1012	belongs to the aldehyde dehydrogenase family
AL492_RS05330	COG0010	Belongs to the arginase family
AL492_RS05340	COG2255	four-way junction helicase activity
AL492_RS05350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL492_RS05355	COG0237	dephospho-CoA kinase activity
AL492_RS05370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL492_RS05385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL492_RS05395	COG1053	succinate dehydrogenase
AL492_RS05405	COG2333	competence protein COMEC
AL492_RS05405	COG0658	competence protein
AL492_RS05410	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL492_RS05430	COG3655	Transcriptional regulator
AL492_RS05435	COG2207	Transcriptional regulator
AL492_RS05440	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL492_RS05445	COG0167	dihydroorotate dehydrogenase activity
AL492_RS05460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL492_RS05465	COG1132	(ABC) transporter
AL492_RS05480	COG4771	TonB-dependent receptor
AL492_RS05485	COG2205	protein histidine kinase activity
AL492_RS05490	COG0745	RESPONSE REGULATOR receiver
AL492_RS05500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AL492_RS05540	COG0495	leucyl-tRNA aminoacylation
AL492_RS05550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL492_RS05550	COG1519	Transferase
AL492_RS05560	COG0791	NLP P60 protein
AL492_RS05580	COG2267	carboxylic ester hydrolase activity
AL492_RS05595	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AL492_RS05600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AL492_RS05605	COG2884	Cell division ATP-binding protein ftsE
AL492_RS05610	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL492_RS05615	COG5000	phosphorelay sensor kinase activity
AL492_RS05620	COG0307	riboflavin synthase, alpha
AL492_RS05625	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL492_RS05635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL492_RS05640	COG0511	ligase activity, forming carbon-carbon bonds
AL492_RS05645	COG0439	Biotin carboxylase
AL492_RS05650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL492_RS05655	COG0463	Glycosyl transferase, family 2
AL492_RS05660	COG4641	Protein conserved in bacteria
AL492_RS05660	COG0438	transferase activity, transferring glycosyl groups
AL492_RS05670	COG0463	Glycosyl transferase, family 2
AL492_RS05695	COG1216	Glycosyl transferase, family 2
AL492_RS05700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL492_RS05705	COG0825	malonyl-CoA metabolic process
AL492_RS05715	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AL492_RS05720	COG0516	GMP reductase activity
AL492_RS05720	COG0517	IMP dehydrogenase activity
AL492_RS05725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL492_RS05735	COG0052	Belongs to the universal ribosomal protein uS2 family
AL492_RS05740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL492_RS05745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL492_RS05765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AL492_RS05765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AL492_RS05765	COG1703	isobutyryl-CoA mutase activity
AL492_RS05815	COG0612	Peptidase, M16
AL492_RS05820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL492_RS05840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL492_RS05850	COG0300	oxidoreductase activity
AL492_RS05870	COG0254	rRNA binding
AL492_RS05875	COG1114	Component of the transport system for branched-chain amino acids
AL492_RS05885	COG1595	DNA-templated transcription, initiation
AL492_RS05910	COG1609	Transcriptional regulator
AL492_RS05915	COG1904	glucuronate isomerase
AL492_RS05920	COG1312	Catalyzes the dehydration of D-mannonate
AL492_RS05925	COG1028	Short-chain dehydrogenase reductase Sdr
AL492_RS05965	COG2949	membrane
AL492_RS05970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL492_RS05980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL492_RS05985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL492_RS05985	COG1754	DNA topoisomerase type I activity
AL492_RS06015	COG1091	dTDP-4-dehydrorhamnose reductase activity
AL492_RS06025	COG0180	Tryptophanyl-tRNA synthetase
AL492_RS06030	COG1609	Transcriptional regulator
AL492_RS06035	COG0246	Mannitol dehydrogenase
AL492_RS06040	COG0738	Major facilitator superfamily
AL492_RS06055	COG1011	Hydrolase
AL492_RS06080	COG1132	(ABC) transporter
AL492_RS06090	COG0688	phosphatidylethanolamine metabolic process
AL492_RS06095	COG4589	Belongs to the CDS family
AL492_RS06105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL492_RS06110	COG0799	negative regulation of ribosome biogenesis
AL492_RS06125	COG0343	queuine tRNA-ribosyltransferase activity
AL492_RS06135	COG0463	Glycosyl transferase, family 2
AL492_RS06150	COG1770	oligopeptidase
AL492_RS06180	COG0437	4 iron, 4 sulfur cluster binding
AL492_RS06220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL492_RS06225	COG3409	Peptidoglycan-binding domain 1 protein
AL492_RS06225	COG0793	Belongs to the peptidase S41A family
AL492_RS06240	COG1368	sulfuric ester hydrolase activity
AL492_RS06245	COG2321	neutral zinc metallopeptidase
AL492_RS06250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL492_RS06255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL492_RS06260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL492_RS06280	COG2081	HI0933 family
AL492_RS06290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL492_RS06300	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL492_RS06305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL492_RS06315	COG2151	metal-sulfur cluster biosynthetic enzyme
AL492_RS06335	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AL492_RS06335	COG0662	Cupin 2, conserved barrel domain protein
AL492_RS06355	COG0606	chelatase, subunit chli
AL492_RS06405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL492_RS06430	COG0019	diaminopimelate decarboxylase activity
AL492_RS06435	COG2176	DNA-directed DNA polymerase activity
AL492_RS06440	COG0433	COG0433 Predicted ATPase
AL492_RS06455	COG3118	belongs to the thioredoxin family
AL492_RS06460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL492_RS06480	COG0811	peptide transport
AL492_RS06495	COG0285	dihydrofolate synthase activity
AL492_RS06515	COG2166	iron-sulfur cluster assembly
AL492_RS06525	COG0542	response to heat
AL492_RS06540	COG1610	YqeY-like protein
AL492_RS06545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL492_RS06565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL492_RS06570	COG2827	Endonuclease containing a URI domain
AL492_RS06575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL492_RS06585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL492_RS06590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL492_RS06595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL492_RS06600	COG0768	penicillin binding
AL492_RS06610	COG0275	rRNA processing
AL492_RS06615	COG2001	Belongs to the MraZ family
AL492_RS06625	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL492_RS06630	COG2153	protein acetylation
AL492_RS06635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL492_RS06645	COG4206	TonB-dependent receptor
AL492_RS06665	COG0653	protein targeting
AL492_RS06675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL492_RS06695	COG1505	serine-type exopeptidase activity
AL492_RS06700	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AL492_RS06705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL492_RS06710	COG1368	sulfuric ester hydrolase activity
AL492_RS06720	COG2304	oxidoreductase activity
AL492_RS06750	COG3033	Beta-eliminating lyase
AL492_RS06765	COG0556	nucleotide-excision repair
AL492_RS06800	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL492_RS06820	COG0363	glucosamine-6-phosphate deaminase activity
AL492_RS06840	COG3279	Response regulator of the LytR AlgR family
AL492_RS06870	COG2032	superoxide dismutase activity
AL492_RS06900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL492_RS06915	COG3264	Mechanosensitive ion channel
AL492_RS06915	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL492_RS06925	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL492_RS06945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL492_RS06965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL492_RS06980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL492_RS06990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL492_RS06995	COG0445	tRNA wobble uridine modification
AL492_RS07005	COG0126	phosphoglycerate kinase activity
AL492_RS07015	COG0698	ribose 5-phosphate isomerase
AL492_RS07020	COG0557	exoribonuclease II activity
AL492_RS07030	COG1619	proteins homologs of microcin C7 resistance protein MccF
AL492_RS07035	COG0792	nuclease activity
AL492_RS07040	COG4221	oxidoreductase activity
AL492_RS07045	COG1214	PFAM Peptidase M22, glycoprotease
AL492_RS07050	COG0424	maF-like protein
AL492_RS07055	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AL492_RS07065	COG1733	regulation of RNA biosynthetic process
AL492_RS07070	COG2814	Major facilitator Superfamily
AL492_RS07075	COG1595	DNA-templated transcription, initiation
AL492_RS07090	COG0481	GTPase activity
AL492_RS07135	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AL492_RS07145	COG1397	ADP-ribosylglycohydrolase
AL492_RS07150	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AL492_RS07205	COG0791	NLP P60 protein
AL492_RS07210	COG0772	Belongs to the SEDS family
AL492_RS07225	COG1792	Involved in formation and maintenance of cell shape
AL492_RS07290	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL492_RS07310	COG0482	sulfurtransferase activity
AL492_RS07320	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL492_RS07330	COG0181	hydroxymethylbilane synthase activity
AL492_RS07335	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL492_RS07350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL492_RS07355	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AL492_RS07380	COG2733	membrane
AL492_RS07385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL492_RS07405	COG0316	Belongs to the HesB IscA family
AL492_RS07410	COG0719	Fe-S assembly protein
AL492_RS07415	COG0396	ATPase activity
AL492_RS07425	COG0719	Fe-S assembly protein
AL492_RS07430	COG0393	Putative heavy-metal-binding
AL492_RS07440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL492_RS07445	COG0025	NhaP-type Na H and K H
AL492_RS07465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL492_RS07470	COG0423	glycine-tRNA ligase activity
AL492_RS07485	COG0700	Nucleoside recognition
AL492_RS07500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL492_RS07510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL492_RS07530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL492_RS07535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL492_RS07550	COG1774	PSP1 C-terminal conserved region
AL492_RS07560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL492_RS07565	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL492_RS07580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL492_RS07585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL492_RS07595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL492_RS07605	COG0387	Pfam Sodium calcium exchanger
AL492_RS07625	COG3591	Belongs to the peptidase S1B family
AL492_RS07635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL492_RS07645	COG3829	transcription factor binding
AL492_RS07670	COG0594	ribonuclease P activity
AL492_RS07675	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL492_RS07685	COG1309	transcriptional regulator
AL492_RS07720	COG0497	DNA recombination
AL492_RS07735	COG1131	(ABC) transporter
AL492_RS07750	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AL492_RS07750	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AL492_RS07760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL492_RS07765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AL492_RS07765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AL492_RS07780	COG1690	Belongs to the RtcB family
AL492_RS07790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AL492_RS07800	COG1703	isobutyryl-CoA mutase activity
AL492_RS07830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL492_RS07835	COG0602	queuosine metabolic process
AL492_RS07840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL492_RS07845	COG0166	Belongs to the GPI family
AL492_RS07860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL492_RS07865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL492_RS07870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL492_RS07875	COG0247	lactate metabolic process
AL492_RS07875	COG2181	nitrate reductase activity
AL492_RS07880	COG2181	nitrate reductase activity
AL492_RS07880	COG0247	lactate metabolic process
AL492_RS07895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL492_RS07940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL492_RS07945	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL492_RS07950	COG0564	pseudouridine synthase activity
AL492_RS07960	COG0137	argininosuccinate synthase activity
AL492_RS07965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL492_RS07980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL492_RS07990	COG0165	Argininosuccinate lyase
AL492_RS07995	COG1522	sequence-specific DNA binding
AL492_RS08015	COG3275	phosphorelay sensor kinase activity
AL492_RS08020	COG3279	Response regulator of the LytR AlgR family
AL492_RS08075	COG1607	acyl-coa hydrolase
AL492_RS08080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL492_RS08085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AL492_RS08120	COG1024	Enoyl-CoA hydratase
AL492_RS08135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL492_RS08155	COG1629	transport
AL492_RS08155	COG4206	TonB-dependent receptor
AL492_RS08185	COG1472	Belongs to the glycosyl hydrolase 3 family
AL492_RS08205	COG1611	Belongs to the LOG family
AL492_RS08210	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AL492_RS08230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL492_RS08235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL492_RS08270	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL492_RS08275	COG0328	RNA-DNA hybrid ribonuclease activity
AL492_RS08280	COG0305	Participates in initiation and elongation during chromosome replication
AL492_RS08300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL492_RS08305	COG0193	aminoacyl-tRNA hydrolase activity
AL492_RS08310	COG0659	secondary active sulfate transmembrane transporter activity
AL492_RS08320	COG0288	reversible hydration of carbon dioxide
AL492_RS08325	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AL492_RS08330	COG1082	Xylose isomerase domain protein TIM barrel
AL492_RS08335	COG0779	Required for maturation of 30S ribosomal subunits
AL492_RS08340	COG0195	Participates in both transcription termination and antitermination
AL492_RS08345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL492_RS08350	COG1629	transport
AL492_RS08365	COG4771	TonB-dependent receptor
AL492_RS08380	COG1629	transport
AL492_RS08395	COG1629	transport
AL492_RS08420	COG4771	TonB-dependent receptor
AL492_RS08435	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AL492_RS08440	COG1388	LysM domain
AL492_RS08440	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL492_RS08455	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL492_RS08460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL492_RS08465	COG4771	TonB-dependent receptor
AL492_RS08480	COG2814	Major facilitator Superfamily
AL492_RS08490	COG1940	carbohydrate kinase activity
AL492_RS08510	COG0268	Binds directly to 16S ribosomal RNA
AL492_RS08530	COG0251	oxidation-reduction process
AL492_RS08540	COG1629	transport
AL492_RS08550	COG4771	TonB-dependent receptor
AL492_RS08555	COG0702	epimerase
AL492_RS08560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL492_RS08565	COG1054	Belongs to the UPF0176 family
AL492_RS08590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL492_RS08615	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL492_RS08620	COG0783	Belongs to the Dps family
AL492_RS08630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AL492_RS08635	COG0049	tRNA binding
AL492_RS08640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL492_RS08645	COG0051	transcription antitermination factor activity, RNA binding
AL492_RS08685	COG3250	beta-galactosidase activity
AL492_RS08720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL492_RS08725	COG0088	Forms part of the polypeptide exit tunnel
AL492_RS08730	COG0089	rRNA binding
AL492_RS08735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL492_RS08740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL492_RS08745	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL492_RS08750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL492_RS08755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL492_RS08760	COG0255	Belongs to the universal ribosomal protein uL29 family
AL492_RS08765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL492_RS08770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL492_RS08775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL492_RS08780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL492_RS08785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL492_RS08790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL492_RS08795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL492_RS08800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL492_RS08805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AL492_RS08810	COG1841	ribosomal large subunit assembly
AL492_RS08815	COG0200	Binds to the 23S rRNA
AL492_RS08820	COG0201	protein transport
AL492_RS08825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL492_RS08830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL492_RS08835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL492_RS08840	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL492_RS08845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL492_RS08850	COG0202	RNA polymerase activity
AL492_RS08855	COG0203	ribosomal protein L17
AL492_RS08865	COG0148	phosphopyruvate hydratase activity
AL492_RS08875	COG1834	amidinotransferase
AL492_RS08880	COG2873	o-acetylhomoserine
AL492_RS08900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL492_RS08905	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AL492_RS08905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL492_RS08910	COG0501	Belongs to the peptidase M48B family
AL492_RS08915	COG0488	(ABC) transporter
AL492_RS08920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL492_RS08930	COG0217	transcriptional regulatory protein
AL492_RS08965	COG0714	Associated with various cellular activities
AL492_RS08975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL492_RS09000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL492_RS09005	COG0460	homoserine dehydrogenase
AL492_RS09005	COG0527	aspartate kinase activity
AL492_RS09020	COG0646	methionine synthase
AL492_RS09020	COG1410	methionine synthase
AL492_RS09035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL492_RS09055	COG0247	lactate metabolic process
AL492_RS09060	COG1139	Iron-sulfur cluster binding protein
AL492_RS09065	COG1556	Lactate utilization protein
AL492_RS09070	COG0738	Major facilitator superfamily
AL492_RS09075	COG2721	sulfolactate sulfo-lyase activity
AL492_RS09080	COG1028	Short-chain dehydrogenase reductase Sdr
AL492_RS09085	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL492_RS09090	COG3254	rhamnose metabolic process
AL492_RS09100	COG1028	Short-chain dehydrogenase reductase Sdr
AL492_RS09115	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AL492_RS09135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL492_RS09155	COG4585	Histidine kinase
AL492_RS09165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL492_RS09175	COG1396	sequence-specific DNA binding
AL492_RS09180	COG1629	transport
AL492_RS09185	COG0702	epimerase
AL492_RS09255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL492_RS09260	COG0366	Alpha amylase catalytic
AL492_RS09300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL492_RS09305	COG0085	RNA polymerase activity
AL492_RS09330	COG4771	TonB-dependent receptor
AL492_RS09335	COG3250	beta-galactosidase activity
AL492_RS09375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL492_RS09410	COG2207	Transcriptional regulator
AL492_RS09560	COG1858	cytochrome C peroxidase
AL492_RS09645	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AL492_RS09650	COG0438	transferase activity, transferring glycosyl groups
AL492_RS09655	COG1472	Belongs to the glycosyl hydrolase 3 family
AL492_RS09660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL492_RS09675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL492_RS09690	COG0756	dUTP diphosphatase activity
AL492_RS09700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AL492_RS09705	COG3537	Alpha-1,2-mannosidase
AL492_RS09710	COG1028	Short-chain dehydrogenase reductase Sdr
AL492_RS09745	COG0542	response to heat
AL492_RS09750	COG3842	ATPase activity
AL492_RS09765	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AL492_RS09770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL492_RS09780	COG3396	Phenylacetate-CoA oxygenase
AL492_RS09785	COG3460	Phenylacetate-CoA oxygenase
AL492_RS09795	COG1073	alpha beta
AL492_RS09800	COG2151	metal-sulfur cluster biosynthetic enzyme
AL492_RS09805	COG1024	Enoyl-CoA hydratase
AL492_RS09810	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL492_RS09820	COG0183	Belongs to the thiolase family
AL492_RS09840	COG1012	belongs to the aldehyde dehydrogenase family
AL492_RS09840	COG2030	dehydratase
AL492_RS09880	COG1408	metallophosphoesterase
AL492_RS09905	COG1490	D-aminoacyl-tRNA deacylase activity
AL492_RS09910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL492_RS09920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL492_RS09970	COG0281	malic enzyme
AL492_RS09970	COG0280	phosphate acetyltransferase
AL492_RS09975	COG0632	four-way junction helicase activity
AL492_RS09980	COG0509	glycine decarboxylation via glycine cleavage system
AL492_RS09995	COG0028	Belongs to the TPP enzyme family
AL492_RS10005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL492_RS10010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL492_RS10045	COG4771	TonB-dependent receptor
AL492_RS10060	COG1629	transport
AL492_RS10075	COG0339	signal peptide processing
AL492_RS10085	COG0475	glutathione-regulated potassium exporter activity
AL492_RS10085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL492_RS10105	COG1704	LemA family
AL492_RS10110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AL492_RS10125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL492_RS10130	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL492_RS10135	COG0515	serine threonine protein kinase
AL492_RS10140	COG0564	pseudouridine synthase activity
AL492_RS10145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL492_RS10155	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL492_RS10160	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL492_RS10180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL492_RS10190	COG1733	regulation of RNA biosynthetic process
AL492_RS10195	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL492_RS10210	COG0101	tRNA pseudouridine synthase activity
AL492_RS10220	COG1132	(ABC) transporter
AL492_RS10230	COG0228	four-way junction DNA binding
AL492_RS10235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL492_RS10255	COG0017	Asparaginyl-tRNA synthetase
AL492_RS10280	COG2326	polyphosphate kinase activity
AL492_RS10285	COG3214	Protein conserved in bacteria
AL492_RS10295	COG0525	valine-tRNA ligase activity
AL492_RS10305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL492_RS10315	COG1418	mRNA catabolic process
AL492_RS10325	COG1629	transport
AL492_RS10330	COG0702	epimerase
AL492_RS10365	COG1136	(ABC) transporter
AL492_RS10365	COG0577	efflux transmembrane transporter activity
AL492_RS10370	COG1136	(ABC) transporter
AL492_RS10410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL492_RS10415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL492_RS10430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL492_RS10440	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AL492_RS10445	COG1216	Glycosyl transferase, family 2
AL492_RS10450	COG1216	Glycosyl transferase, family 2
AL492_RS10455	COG1215	transferase activity, transferring glycosyl groups
AL492_RS10470	COG0463	Glycosyl transferase, family 2
AL492_RS10495	COG1216	Glycosyl transferase, family 2
AL492_RS10495	COG1442	glycosyl transferase family 8
AL492_RS10505	COG0438	transferase activity, transferring glycosyl groups
AL492_RS10510	COG0438	transferase activity, transferring glycosyl groups
AL492_RS10535	COG1132	(ABC) transporter
AL492_RS10550	COG3206	protein involved in exopolysaccharide biosynthesis
AL492_RS10550	COG0489	protein tyrosine kinase activity
AL492_RS10560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL492_RS10565	COG2137	regulation of response to DNA damage stimulus
AL492_RS10580	COG0489	protein tyrosine kinase activity
AL492_RS10580	COG3206	protein involved in exopolysaccharide biosynthesis
AL492_RS10610	COG0438	transferase activity, transferring glycosyl groups
AL492_RS10615	COG0438	transferase activity, transferring glycosyl groups
AL492_RS10625	COG1086	Polysaccharide biosynthesis protein
AL492_RS10650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL492_RS10655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL492_RS10680	COG1137	ATPase activity
AL492_RS10685	COG1132	(ABC) transporter
AL492_RS10710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL492_RS10735	COG0010	Belongs to the arginase family
AL492_RS10755	COG0456	acetyltransferase
AL492_RS10760	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL492_RS10765	COG0297	glycogen (starch) synthase activity
AL492_RS10775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL492_RS10785	COG1959	2 iron, 2 sulfur cluster binding
AL492_RS10790	COG0175	sulfate reduction
AL492_RS10795	COG0175	sulfate reduction
AL492_RS10805	COG1045	serine acetyltransferase
AL492_RS10815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL492_RS10815	COG1648	precorrin-2 dehydrogenase activity
AL492_RS10820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL492_RS10865	COG1196	nuclear chromosome segregation
AL492_RS10865	COG3264	Mechanosensitive ion channel
AL492_RS10890	COG0784	Response regulator, receiver
AL492_RS10890	COG2205	protein histidine kinase activity
AL492_RS10905	COG1309	transcriptional regulator
AL492_RS10960	COG0252	asparaginase activity
AL492_RS10975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL492_RS10985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL492_RS10995	COG1522	sequence-specific DNA binding
AL492_RS11035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL492_RS11065	COG1309	transcriptional regulator
AL492_RS11090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL492_RS11100	COG0714	Associated with various cellular activities
AL492_RS11125	COG2304	oxidoreductase activity
AL492_RS11140	COG2095	MarC family integral membrane protein
AL492_RS11150	COG1169	isochorismate synthase
AL492_RS11155	COG2050	protein possibly involved in aromatic compounds catabolism
AL492_RS11205	COG1193	negative regulation of DNA recombination
AL492_RS11215	COG5492	domain, Protein
AL492_RS11220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL492_RS11255	COG0668	transmembrane transport
AL492_RS11265	COG2267	carboxylic ester hydrolase activity
AL492_RS11275	COG1022	Amp-dependent synthetase and ligase
AL492_RS11285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL492_RS11305	COG0346	lactoylglutathione lyase activity
AL492_RS11320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL492_RS11325	COG1187	pseudouridine synthase activity
AL492_RS11330	COG0697	spore germination
AL492_RS11340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL492_RS11350	COG3425	synthase
AL492_RS11355	COG0612	Peptidase, M16
AL492_RS11380	COG1012	belongs to the aldehyde dehydrogenase family
AL492_RS11400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL492_RS11405	COG1301	dicarboxylic acid transport
AL492_RS11420	COG0492	ferredoxin-NADP+ reductase activity
AL492_RS11440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL492_RS11460	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL492_RS11465	COG0527	aspartate kinase activity
AL492_RS11565	COG3634	alkyl hydroperoxide reductase activity
AL492_RS11610	COG3047	cAMP biosynthetic process
AL492_RS11610	COG2885	chlorophyll binding
AL492_RS11640	COG0025	NhaP-type Na H and K H
AL492_RS11655	COG0589	response to stress
AL492_RS11670	COG2814	Major facilitator Superfamily
AL492_RS11680	COG2909	trisaccharide binding
AL492_RS11710	COG0346	lactoylglutathione lyase activity
AL492_RS11715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL492_RS11725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL492_RS11735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL492_RS11735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL492_RS11740	COG1739	Uncharacterized protein family UPF0029
AL492_RS11755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL492_RS11765	COG0667	Aldo Keto reductase
AL492_RS11770	COG1757	Na H antiporter
AL492_RS11785	COG2814	Major facilitator Superfamily
AL492_RS11800	COG2132	Multicopper oxidase
AL492_RS11815	COG1024	Enoyl-CoA hydratase
AL492_RS11830	COG4290	ribonuclease
AL492_RS11865	COG2207	Transcriptional regulator
AL492_RS11865	COG4753	response regulator
AL492_RS11875	COG2207	Transcriptional regulator
AL492_RS11875	COG4753	response regulator
AL492_RS11885	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL492_RS11895	COG0464	growth
AL492_RS11915	COG0732	type I restriction modification DNA specificity domain
AL492_RS11925	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AL492_RS11935	COG2003	Belongs to the UPF0758 family
AL492_RS11975	COG4771	TonB-dependent receptor
AL492_RS11980	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AL492_RS11985	COG3852	Histidine kinase
AL492_RS11990	COG2204	response regulator
AL492_RS12015	COG1136	(ABC) transporter
AL492_RS12020	COG0577	efflux transmembrane transporter activity
AL492_RS12020	COG1136	(ABC) transporter
AL492_RS12035	COG0577	efflux transmembrane transporter activity
AL492_RS12040	COG0577	efflux transmembrane transporter activity
AL492_RS12060	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL492_RS12070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL492_RS12075	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL492_RS12085	COG3720	iron ion transport
AL492_RS12095	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL492_RS12105	COG3119	arylsulfatase activity
AL492_RS12115	COG1063	alcohol dehydrogenase
AL492_RS12195	COG3781	membrane
AL492_RS12215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL492_RS12230	COG3275	phosphorelay sensor kinase activity
AL492_RS12235	COG3279	Response regulator of the LytR AlgR family
AL492_RS12295	COG0527	aspartate kinase activity
AL492_RS12305	COG0477	Major facilitator Superfamily
AL492_RS12330	COG0321	lipoyl(octanoyl) transferase activity
AL492_RS12330	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AL492_RS12345	COG3813	Protein conserved in bacteria
AL492_RS12350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL492_RS12355	COG2239	Acts as a magnesium transporter
AL492_RS12365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL492_RS12375	COG1185	polyribonucleotide nucleotidyltransferase activity
AL492_RS12395	COG0837	glucose binding
AL492_RS12415	COG1760	l-serine dehydratase
AL492_RS12430	COG0287	Prephenate dehydrogenase
AL492_RS12435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL492_RS12445	COG0686	Belongs to the AlaDH PNT family
AL492_RS12465	COG1078	dGTPase activity
AL492_RS12470	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL492_RS12475	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL492_RS12475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL492_RS12480	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL492_RS12485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL492_RS12490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL492_RS12495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AL492_RS12510	COG4152	abc transporter atp-binding protein
AL492_RS12515	COG1446	asparaginase
AL492_RS12520	COG2104	thiamine diphosphate biosynthetic process
AL492_RS12535	COG0352	thiamine-phosphate diphosphorylase activity
AL492_RS12540	COG2022	thiamine diphosphate biosynthetic process
AL492_RS12545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL492_RS12575	COG1285	pathogenesis
AL492_RS12595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AL492_RS12600	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL492_RS12625	COG0456	acetyltransferase
AL492_RS12630	COG5006	permease, DMT superfamily
AL492_RS12635	COG0456	acetyltransferase
AL492_RS12640	COG5002	protein histidine kinase activity
AL492_RS12645	COG0745	RESPONSE REGULATOR receiver
AL492_RS12685	COG1028	Short-chain dehydrogenase reductase Sdr
AL492_RS12700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL492_RS12755	COG0798	PFAM Bile acid sodium symporter
AL492_RS12760	COG1764	response to oxidative stress
AL492_RS12765	COG2186	Transcriptional regulator
AL492_RS12770	COG0730	response to heat
AL492_RS12795	COG0823	Involved in the tonB-independent uptake of proteins
AL492_RS12810	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AL492_RS12815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL492_RS12820	COG1595	DNA-templated transcription, initiation
AL492_RS12835	COG3548	integral membrane protein
AL492_RS12840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL492_RS12845	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AL492_RS12845	COG2755	lipolytic protein G-D-S-L family
AL492_RS12855	COG2814	Major facilitator Superfamily
AL492_RS12875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL492_RS12895	COG2217	Heavy metal translocating P-type atpase
AL492_RS12910	COG2723	6-phospho-beta-galactosidase activity
AL492_RS12965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL492_RS12970	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL492_RS12980	COG0484	heat shock protein binding
AL492_RS12985	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL492_RS13005	COG0442	prolyl-tRNA aminoacylation
AL492_RS13035	COG0116	Belongs to the methyltransferase superfamily
AL492_RS13040	COG1216	Glycosyl transferase, family 2
AL492_RS13040	COG0463	Glycosyl transferase, family 2
AL492_RS13050	COG4221	oxidoreductase activity
AL492_RS13055	COG1473	amidohydrolase
AL492_RS13065	COG0022	dehydrogenase e1 component
AL492_RS13110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL492_RS13130	COG2910	NAD(P)H-binding
AL492_RS13150	COG2207	Transcriptional regulator
AL492_RS13190	COG0363	glucosamine-6-phosphate deaminase activity
AL492_RS13195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL492_RS13200	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL492_RS13220	COG1629	transport
AL492_RS13230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL492_RS13245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL492_RS13295	COG2837	iron assimilation
AL492_RS13310	COG1733	regulation of RNA biosynthetic process
AL492_RS13315	COG1428	Deoxynucleoside kinase
AL492_RS13335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL492_RS13340	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AL492_RS13420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL492_RS13425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL492_RS13440	COG0531	amino acid
AL492_RS13450	COG2706	6-phosphogluconolactonase activity
AL492_RS13465	COG1575	Belongs to the MenA family. Type 1 subfamily
AL492_RS13475	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AL492_RS13500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL492_RS13515	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL492_RS13525	COG0386	Belongs to the glutathione peroxidase family
AL492_RS13535	COG3250	beta-galactosidase activity
AL492_RS13545	COG0196	riboflavin kinase activity
AL492_RS13550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL492_RS13555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL492_RS13575	COG1696	Membrane protein involved in D-alanine export
AL492_RS13595	COG0156	8-amino-7-oxononanoate synthase activity
AL492_RS13615	COG2076	Multidrug Resistance protein
AL492_RS13625	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL492_RS13640	COG0805	protein transport
AL492_RS13645	COG0517	IMP dehydrogenase activity
AL492_RS13645	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL492_RS13650	COG0514	ATP-dependent DNA helicase (RecQ)
AL492_RS13660	COG0724	RNA recognition motif
AL492_RS13675	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL492_RS13675	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL492_RS13680	COG0067	glutamate synthase
AL492_RS13680	COG0070	glutamate synthase
AL492_RS13680	COG0069	glutamate synthase activity
AL492_RS13695	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL492_RS13705	COG3279	Response regulator of the LytR AlgR family
AL492_RS13710	COG3275	phosphorelay sensor kinase activity
AL492_RS13730	COG0673	inositol 2-dehydrogenase activity
AL492_RS13735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AL492_RS13740	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL492_RS13745	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AL492_RS13750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL492_RS13760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL492_RS13765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL492_RS13770	COG0066	3-isopropylmalate dehydratase activity
AL492_RS13795	COG1960	acyl-CoA dehydrogenase activity
AL492_RS13800	COG1119	ATPase activity
AL492_RS13845	COG0513	Belongs to the DEAD box helicase family
AL492_RS13850	COG0539	negative regulation of cytoplasmic translation
AL492_RS13850	COG2183	response to ionizing radiation
AL492_RS13865	COG0004	ammonium transporteR
AL492_RS13870	COG0477	Major facilitator Superfamily
AL492_RS13880	COG2814	Major facilitator Superfamily
AL492_RS13885	COG2207	Transcriptional regulator
AL492_RS13890	COG0494	nUDIX hydrolase
AL492_RS13895	COG0335	large ribosomal subunit rRNA binding
AL492_RS13920	COG0563	adenylate kinase activity
AL492_RS13925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL492_RS13945	COG2207	Transcriptional regulator
AL492_RS14015	COG0028	Belongs to the TPP enzyme family
AL492_RS14035	COG0745	RESPONSE REGULATOR receiver
AL492_RS14045	COG0629	single-stranded DNA binding
AL492_RS14050	COG0124	histidyl-tRNA synthetase
AL492_RS14075	COG1733	regulation of RNA biosynthetic process
AL492_RS14080	COG1902	pentaerythritol trinitrate reductase activity
AL492_RS14085	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AL492_RS14100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL492_RS14105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL492_RS14115	COG1349	DNA-binding transcription factor activity
AL492_RS14120	COG1629	transport
AL492_RS14125	COG0702	epimerase
AL492_RS14135	COG3511	phospholipase C
AL492_RS14145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL492_RS14165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL492_RS14170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL492_RS14180	COG1506	peptidase
AL492_RS14180	COG0823	Involved in the tonB-independent uptake of proteins
AL492_RS14190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL492_RS14195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL492_RS14200	COG2027	D-alanyl-D-alanine carboxypeptidase
AL492_RS14210	COG0584	glycerophosphoryl diester phosphodiesterase
AL492_RS14215	COG0671	phosphoesterase, PA-phosphatase related
AL492_RS14220	COG2217	Heavy metal translocating P-type atpase
AL492_RS14235	COG1607	acyl-coa hydrolase
AL492_RS14240	COG0069	glutamate synthase activity
AL492_RS14255	COG0359	binds to the 23S rRNA
AL492_RS14260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AL492_RS14265	COG0360	Binds together with S18 to 16S ribosomal RNA
AL492_RS14290	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AL492_RS14320	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL492_RS14325	COG0321	lipoyl(octanoyl) transferase activity
AL492_RS14330	COG0745	RESPONSE REGULATOR receiver
AL492_RS14355	COG3153	acetyltransferase
AL492_RS14355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL492_RS14370	COG0534	Mate efflux family protein
AL492_RS14385	COG2197	response regulator
AL492_RS14410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL492_RS14420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL492_RS14430	COG1022	Amp-dependent synthetase and ligase
AL492_RS14435	COG1960	acyl-CoA dehydrogenase activity
AL492_RS14445	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AL492_RS14460	COG1566	PFAM secretion protein HlyD family protein
AL492_RS14480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL492_RS14480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL492_RS14500	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL492_RS14510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL492_RS14515	COG2027	D-alanyl-D-alanine carboxypeptidase
AL492_RS14520	COG0156	8-amino-7-oxononanoate synthase activity
AL492_RS14540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL492_RS14545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AL492_RS14565	COG2197	response regulator
AL492_RS14580	COG0022	dehydrogenase e1 component
AL492_RS14590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL492_RS14595	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL492_RS14615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL492_RS14620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL492_RS14625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL492_RS14650	COG1321	iron dependent repressor
AL492_RS14670	COG0519	Catalyzes the synthesis of GMP from XMP
AL492_RS14685	COG0813	purine-nucleoside phosphorylase activity
AL492_RS14695	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL492_RS14700	COG0456	acetyltransferase
AL492_RS14720	COG2226	methyltransferase
AL492_RS14725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL492_RS14735	COG1506	peptidase
AL492_RS14745	COG0488	(ABC) transporter
AL492_RS14755	COG1113	amino acid transport
AL492_RS14770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL492_RS14795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL492_RS14820	COG4654	Cytochrome c, class I
AL492_RS14830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL492_RS14840	COG0667	Aldo Keto reductase
AL492_RS14850	COG2814	Major facilitator Superfamily
AL492_RS14895	COG1271	oxidase subunit
AL492_RS14900	COG0187	DNA topoisomerase II activity
AL492_RS14910	COG3279	Response regulator of the LytR AlgR family
AL492_RS15000	COG1538	Outer membrane efflux protein
AL492_RS15010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL492_RS15030	COG3279	Response regulator of the LytR AlgR family
AL492_RS15095	COG0431	NADPH-dependent FMN reductase
AL492_RS15100	COG0346	lactoylglutathione lyase activity
AL492_RS15120	COG1131	(ABC) transporter
AL492_RS15140	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AL492_RS15145	COG0076	glutamate decarboxylase activity
AL492_RS15150	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AL492_RS15155	COG2211	Major facilitator Superfamily
AL492_RS15160	COG4977	sequence-specific DNA binding
AL492_RS15185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL492_RS15210	COG3012	SEC-C Motif Domain Protein
AL492_RS15215	COG1280	lysine exporter protein (LysE YggA)
AL492_RS15240	COG0436	Aminotransferase
AL492_RS15250	COG0012	GTP binding
AL492_RS15270	COG0357	Ribosomal RNA small subunit methyltransferase G
AL492_RS15275	COG0436	Aminotransferase
AL492_RS15280	COG0612	Peptidase, M16
AL492_RS15285	COG0450	alkyl hydroperoxide reductase
AL492_RS15305	COG1803	Methylglyoxal synthase
AL492_RS15335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL492_RS15340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL492_RS15350	COG0105	UTP biosynthetic process
AL492_RS15355	COG2270	Major facilitator Superfamily
AL492_RS15360	COG0183	Belongs to the thiolase family
AL492_RS15370	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL492_RS15375	COG0083	homoserine kinase activity
AL492_RS15380	COG0460	homoserine dehydrogenase
AL492_RS15380	COG0527	aspartate kinase activity
AL492_RS15385	COG0702	epimerase
AL492_RS15390	COG1629	transport
AL492_RS15400	COG1446	asparaginase
AL492_RS15415	COG2211	Major facilitator Superfamily
AL492_RS15425	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AL492_RS15435	COG1028	Short-chain dehydrogenase reductase Sdr
AL492_RS15455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AL492_RS15455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AL492_RS15465	COG0572	uridine kinase
AL492_RS15480	COG2949	membrane
AL492_RS15485	COG1017	nitric oxide dioxygenase activity
AL492_RS15485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL492_RS15490	COG3118	belongs to the thioredoxin family
AL492_RS15500	COG1120	ATPase activity
AL492_RS15510	COG1024	Enoyl-CoA hydratase
AL492_RS15510	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL492_RS15515	COG0183	Belongs to the thiolase family
AL492_RS15520	COG1960	acyl-CoA dehydrogenase activity
AL492_RS15560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL492_RS15565	COG1968	undecaprenyl-diphosphatase activity
AL492_RS15575	COG2177	Part of the ABC transporter FtsEX involved in
AL492_RS15580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL492_RS15595	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AL492_RS15610	COG0670	Belongs to the BI1 family
AL492_RS15620	COG1234	tRNA 3'-trailer cleavage
AL492_RS15625	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL492_RS15660	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL492_RS15665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL492_RS15670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL492_RS15680	COG3340	Belongs to the peptidase S51 family
AL492_RS15685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL492_RS15700	COG1595	DNA-templated transcription, initiation
AL492_RS15705	COG4946	Tricorn protease homolog
AL492_RS15705	COG1506	peptidase
AL492_RS15705	COG0823	Involved in the tonB-independent uptake of proteins
AL492_RS15710	COG0006	proline dipeptidase activity
AL492_RS15715	COG2207	Transcriptional regulator
AL492_RS15720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL492_RS15730	COG3938	Belongs to the proline racemase family
AL492_RS15780	COG4206	TonB-dependent receptor
AL492_RS15780	COG1629	transport
AL492_RS15785	COG0295	cytidine deaminase activity
AL492_RS15795	COG4771	TonB-dependent receptor
AL492_RS15800	COG1295	ribonuclease BN
AL492_RS15805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL492_RS15815	COG0671	phosphoesterase, PA-phosphatase related
AL492_RS15830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL492_RS15845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL492_RS15855	COG0531	amino acid
AL492_RS15865	COG1217	gtp-binding protein TYPA
AL492_RS15930	COG0303	'Molybdopterin
AL492_RS15945	COG0746	molybdenum cofactor guanylyltransferase activity
AL492_RS15960	COG3781	membrane
AL492_RS15980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL492_RS15985	COG0314	molybdopterin synthase activity
AL492_RS16085	COG0531	amino acid
AL492_RS16095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL492_RS16105	COG0512	Glutamine amidotransferase of anthranilate synthase
AL492_RS16110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL492_RS16115	COG0134	indole-3-glycerol-phosphate synthase activity
AL492_RS16120	COG0135	phosphoribosylanthranilate isomerase activity
AL492_RS16130	COG0133	tryptophan synthase activity
AL492_RS16135	COG0159	tryptophan synthase activity
AL492_RS16165	COG0463	Glycosyl transferase, family 2
AL492_RS16175	COG2171	N-acyltransferase activity
AL492_RS16180	COG0791	NLP P60 protein
AL492_RS16215	COG1012	belongs to the aldehyde dehydrogenase family
AL492_RS16235	COG0745	RESPONSE REGULATOR receiver
AL492_RS16305	COG2855	membrane
AL492_RS16310	COG0583	DNA-binding transcription factor activity
AL492_RS16340	COG0505	Belongs to the CarA family
AL492_RS16350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL492_RS16370	COG0077	Prephenate dehydratase
AL492_RS16375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL492_RS16385	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL492_RS16390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL492_RS16395	COG1970	mechanosensitive ion channel activity
AL492_RS16400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL492_RS16425	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AL492_RS16430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL492_RS16455	COG0009	L-threonylcarbamoyladenylate synthase
AL492_RS16460	COG3022	response to hydroperoxide
AL492_RS16465	COG2890	protein-(glutamine-N5) methyltransferase activity
AL492_RS16480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL492_RS16485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL492_RS16485	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL492_RS16505	COG1363	Peptidase, m42
AL492_RS16510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AL492_RS16535	COG0242	peptide deformylase activity
AL492_RS16545	COG3118	belongs to the thioredoxin family
AL492_RS16555	COG1335	isochorismatase
AL492_RS16570	COG1187	pseudouridine synthase activity
AL492_RS16590	COG1131	(ABC) transporter
AL492_RS16600	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AL492_RS16600	COG1605	Chorismate mutase
AL492_RS16610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AL492_RS16615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL492_RS16620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AL492_RS16625	COG2003	Belongs to the UPF0758 family
AL492_RS16655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AL492_RS16660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL492_RS16680	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL492_RS16685	COG3153	acetyltransferase
AL492_RS16705	COG1979	alcohol dehydrogenase
AL492_RS16725	COG0513	Belongs to the DEAD box helicase family
AL492_RS16730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL492_RS16735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL492_RS16735	COG0519	Catalyzes the synthesis of GMP from XMP
AL492_RS16740	COG0151	Belongs to the GarS family
AL492_RS16755	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL492_RS16760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL492_RS16770	COG1741	Belongs to the pirin family
AL492_RS16780	COG1082	Xylose isomerase domain protein TIM barrel
AL492_RS16785	COG3408	Glycogen debranching enzyme
AL492_RS16785	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AL492_RS16795	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AL492_RS16800	COG4206	TonB-dependent receptor
AL492_RS16800	COG1629	transport
AL492_RS16805	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL492_RS16810	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL492_RS16830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL492_RS16835	COG2133	pyrroloquinoline quinone binding
AL492_RS16870	COG0697	spore germination
AL492_RS16875	COG2967	ApaG domain
AL492_RS16880	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL492_RS16895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL492_RS16900	COG0297	glycogen (starch) synthase activity
AL492_RS16905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL492_RS16935	COG0667	Aldo Keto reductase
AL492_RS16945	COG2814	Major facilitator Superfamily
AL492_RS16950	COG0583	DNA-binding transcription factor activity
AL492_RS16955	COG3537	Alpha-1,2-mannosidase
AL492_RS16965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL492_RS16970	COG0598	Magnesium transport protein CorA
AL492_RS17005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL492_RS17010	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL492_RS17020	COG1289	transmembrane transporter activity
AL492_RS17030	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AL492_RS17060	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL492_RS17070	COG0025	NhaP-type Na H and K H
AL492_RS17075	COG3781	membrane
AL492_RS17090	COG1846	Transcriptional regulator
AL492_RS17095	COG1764	response to oxidative stress
AL492_RS17105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL492_RS17135	COG1309	transcriptional regulator
AL492_RS17155	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL492_RS17160	COG0456	acetyltransferase
AL492_RS17180	COG1611	Belongs to the LOG family
AL492_RS17195	COG0534	Mate efflux family protein
AL492_RS17200	COG2375	cellular response to nickel ion
AL492_RS17205	COG2207	Transcriptional regulator
AL492_RS17205	COG0662	Cupin 2, conserved barrel domain protein
AL492_RS17225	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AL492_RS17240	COG0523	cobalamin synthesis protein
AL492_RS17315	COG4771	TonB-dependent receptor
AL492_RS17355	COG3781	membrane
AL492_RS17365	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AL492_RS17440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL492_RS17460	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL492_RS17465	COG0656	L-ascorbic acid biosynthetic process
AL492_RS17475	COG0242	peptide deformylase activity
AL492_RS17480	COG0024	Methionine aminopeptidase
AL492_RS17545	COG0519	Catalyzes the synthesis of GMP from XMP
AL492_RS17550	COG0300	oxidoreductase activity
AL492_RS17575	COG0415	Belongs to the DNA photolyase family
AL492_RS17580	COG2197	response regulator
AL492_RS17640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL492_RS17650	COG1028	Short-chain dehydrogenase reductase Sdr
AL492_RS17680	COG3392	D12 class N6 adenine-specific DNA methyltransferase
AL492_RS17780	COG0740	serine-type endopeptidase activity
AL492_RS17850	COG1876	peptidase activity
AL492_RS17960	COG0431	NADPH-dependent FMN reductase
AL492_RS17975	COG2957	Belongs to the agmatine deiminase family
AL492_RS17980	COG3279	Response regulator of the LytR AlgR family
AL492_RS17985	COG3275	phosphorelay sensor kinase activity
AL492_RS18005	COG2207	Transcriptional regulator
AL492_RS18015	COG0778	Nitroreductase
AL492_RS18025	COG1733	regulation of RNA biosynthetic process
AL492_RS18030	COG1733	regulation of RNA biosynthetic process
AL492_RS18040	COG1785	Belongs to the alkaline phosphatase family
AL492_RS18045	COG2076	Multidrug Resistance protein
AL492_RS18065	COG0348	domain, Protein
AL492_RS18070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL492_RS18070	COG2207	Transcriptional regulator
AL492_RS18090	COG2194	sulfuric ester hydrolase activity
AL492_RS18100	COG2814	Major facilitator Superfamily
AL492_RS18105	COG1234	tRNA 3'-trailer cleavage
AL492_RS18110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL492_RS18115	COG1999	signal sequence binding
AL492_RS18130	COG1028	Short-chain dehydrogenase reductase Sdr
AL492_RS18145	COG1064	alcohol dehydrogenase
AL492_RS18195	COG3708	Transcriptional regulator
AL492_RS18205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AL492_RS18215	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL492_RS18220	COG0697	spore germination
AL492_RS18225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL492_RS18250	COG0596	Alpha beta hydrolase
AL492_RS18270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity