locus-tag	class	description
A6J37_RS00020	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A6J37_RS00035	COG1028	Short-chain dehydrogenase reductase Sdr
A6J37_RS00045	COG3254	rhamnose metabolic process
A6J37_RS00050	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6J37_RS00055	COG1028	Short-chain dehydrogenase reductase Sdr
A6J37_RS00060	COG2721	sulfolactate sulfo-lyase activity
A6J37_RS00065	COG0738	Major facilitator superfamily
A6J37_RS00070	COG1556	Lactate utilization protein
A6J37_RS00075	COG1139	Iron-sulfur cluster binding protein
A6J37_RS00080	COG0247	lactate metabolic process
A6J37_RS00100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6J37_RS00115	COG0646	methionine synthase
A6J37_RS00115	COG1410	methionine synthase
A6J37_RS00125	COG0460	homoserine dehydrogenase
A6J37_RS00125	COG0527	aspartate kinase activity
A6J37_RS00130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6J37_RS00155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6J37_RS00165	COG0714	Associated with various cellular activities
A6J37_RS00200	COG0217	transcriptional regulatory protein
A6J37_RS00210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6J37_RS00215	COG0488	(ABC) transporter
A6J37_RS00220	COG0501	Belongs to the peptidase M48B family
A6J37_RS00225	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A6J37_RS00225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6J37_RS00230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6J37_RS00250	COG2873	o-acetylhomoserine
A6J37_RS00255	COG1834	amidinotransferase
A6J37_RS00265	COG0148	phosphopyruvate hydratase activity
A6J37_RS00275	COG0203	ribosomal protein L17
A6J37_RS00280	COG0202	RNA polymerase activity
A6J37_RS00285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6J37_RS00290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6J37_RS00295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6J37_RS00300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6J37_RS00305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6J37_RS00310	COG0201	protein transport
A6J37_RS00315	COG0200	Binds to the 23S rRNA
A6J37_RS00320	COG1841	ribosomal large subunit assembly
A6J37_RS00325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6J37_RS00330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6J37_RS00335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6J37_RS00340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6J37_RS00345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6J37_RS00350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6J37_RS00355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6J37_RS00360	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6J37_RS00365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6J37_RS00370	COG0255	Belongs to the universal ribosomal protein uL29 family
A6J37_RS00375	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6J37_RS00380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6J37_RS00385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6J37_RS00390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6J37_RS00395	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6J37_RS00400	COG0089	rRNA binding
A6J37_RS00405	COG0088	Forms part of the polypeptide exit tunnel
A6J37_RS00410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6J37_RS00445	COG3250	beta-galactosidase activity
A6J37_RS00485	COG0051	transcription antitermination factor activity, RNA binding
A6J37_RS00490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6J37_RS00495	COG0049	tRNA binding
A6J37_RS00500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6J37_RS00510	COG0783	Belongs to the Dps family
A6J37_RS00515	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6J37_RS00540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J37_RS00560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6J37_RS00565	COG1054	Belongs to the UPF0176 family
A6J37_RS00570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J37_RS00575	COG0702	epimerase
A6J37_RS00580	COG4771	TonB-dependent receptor
A6J37_RS00590	COG1629	transport
A6J37_RS00600	COG0251	oxidation-reduction process
A6J37_RS00620	COG0268	Binds directly to 16S ribosomal RNA
A6J37_RS00735	COG1940	carbohydrate kinase activity
A6J37_RS00745	COG2814	Major facilitator Superfamily
A6J37_RS00760	COG4771	TonB-dependent receptor
A6J37_RS00765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6J37_RS00770	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6J37_RS00785	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6J37_RS00785	COG1388	LysM domain
A6J37_RS00790	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A6J37_RS00805	COG4771	TonB-dependent receptor
A6J37_RS00830	COG1629	transport
A6J37_RS00845	COG1629	transport
A6J37_RS00860	COG4771	TonB-dependent receptor
A6J37_RS00875	COG1629	transport
A6J37_RS00880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6J37_RS00885	COG0195	Participates in both transcription termination and antitermination
A6J37_RS00890	COG0779	Required for maturation of 30S ribosomal subunits
A6J37_RS00895	COG1082	Xylose isomerase domain protein TIM barrel
A6J37_RS00900	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A6J37_RS00905	COG0288	reversible hydration of carbon dioxide
A6J37_RS00915	COG0659	secondary active sulfate transmembrane transporter activity
A6J37_RS00920	COG0193	aminoacyl-tRNA hydrolase activity
A6J37_RS00925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6J37_RS00945	COG0305	Participates in initiation and elongation during chromosome replication
A6J37_RS00950	COG0328	RNA-DNA hybrid ribonuclease activity
A6J37_RS00955	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6J37_RS00990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J37_RS00995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6J37_RS01015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6J37_RS01020	COG1611	Belongs to the LOG family
A6J37_RS01055	COG4206	TonB-dependent receptor
A6J37_RS01055	COG1629	transport
A6J37_RS01075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6J37_RS01090	COG1024	Enoyl-CoA hydratase
A6J37_RS01125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J37_RS01130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J37_RS01135	COG1607	acyl-coa hydrolase
A6J37_RS01190	COG3279	Response regulator of the LytR AlgR family
A6J37_RS01195	COG3275	phosphorelay sensor kinase activity
A6J37_RS01215	COG1522	sequence-specific DNA binding
A6J37_RS01220	COG0165	Argininosuccinate lyase
A6J37_RS01230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6J37_RS01245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6J37_RS01250	COG0137	argininosuccinate synthase activity
A6J37_RS01260	COG0564	pseudouridine synthase activity
A6J37_RS01265	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6J37_RS01270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J37_RS01315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6J37_RS01330	COG2181	nitrate reductase activity
A6J37_RS01330	COG0247	lactate metabolic process
A6J37_RS01335	COG2181	nitrate reductase activity
A6J37_RS01335	COG0247	lactate metabolic process
A6J37_RS01340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6J37_RS01345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J37_RS01350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6J37_RS01365	COG0166	Belongs to the GPI family
A6J37_RS01370	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6J37_RS01375	COG0602	queuosine metabolic process
A6J37_RS01380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6J37_RS01410	COG1703	isobutyryl-CoA mutase activity
A6J37_RS01420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6J37_RS01430	COG1690	Belongs to the RtcB family
A6J37_RS01445	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6J37_RS01445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6J37_RS01450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6J37_RS01460	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A6J37_RS01460	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A6J37_RS01465	COG1309	transcriptional regulator
A6J37_RS01470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J37_RS01485	COG4152	abc transporter atp-binding protein
A6J37_RS01495	COG4935	Belongs to the peptidase S8 family
A6J37_RS01495	COG2234	aminopeptidase activity
A6J37_RS01500	COG0497	DNA recombination
A6J37_RS01535	COG1309	transcriptional regulator
A6J37_RS01545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6J37_RS01550	COG0594	ribonuclease P activity
A6J37_RS01575	COG3829	transcription factor binding
A6J37_RS01585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J37_RS01595	COG3591	Belongs to the peptidase S1B family
A6J37_RS01615	COG0387	Pfam Sodium calcium exchanger
A6J37_RS01625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J37_RS01635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6J37_RS01640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6J37_RS01655	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6J37_RS01660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6J37_RS01670	COG1774	PSP1 C-terminal conserved region
A6J37_RS01685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6J37_RS01690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6J37_RS01710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6J37_RS01720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6J37_RS01735	COG0700	Nucleoside recognition
A6J37_RS01750	COG0423	glycine-tRNA ligase activity
A6J37_RS01755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6J37_RS01775	COG0025	NhaP-type Na H and K H
A6J37_RS01780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6J37_RS01790	COG0393	Putative heavy-metal-binding
A6J37_RS01795	COG0719	Fe-S assembly protein
A6J37_RS01805	COG0396	ATPase activity
A6J37_RS01810	COG0719	Fe-S assembly protein
A6J37_RS01815	COG0316	Belongs to the HesB IscA family
A6J37_RS01835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J37_RS01840	COG2733	membrane
A6J37_RS01860	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6J37_RS01865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J37_RS01880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6J37_RS01885	COG0181	hydroxymethylbilane synthase activity
A6J37_RS01895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6J37_RS01905	COG0482	sulfurtransferase activity
A6J37_RS01925	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6J37_RS01990	COG1792	Involved in formation and maintenance of cell shape
A6J37_RS02005	COG0772	Belongs to the SEDS family
A6J37_RS02010	COG0791	NLP P60 protein
A6J37_RS02060	COG1132	(ABC) transporter
A6J37_RS02140	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A6J37_RS02190	COG0481	GTPase activity
A6J37_RS02205	COG1595	DNA-templated transcription, initiation
A6J37_RS02210	COG2814	Major facilitator Superfamily
A6J37_RS02215	COG1733	regulation of RNA biosynthetic process
A6J37_RS02225	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6J37_RS02230	COG0424	maF-like protein
A6J37_RS02235	COG1214	PFAM Peptidase M22, glycoprotease
A6J37_RS02240	COG4221	oxidoreductase activity
A6J37_RS02245	COG0792	nuclease activity
A6J37_RS02250	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6J37_RS02260	COG0557	exoribonuclease II activity
A6J37_RS02265	COG0698	ribose 5-phosphate isomerase
A6J37_RS02270	COG0126	phosphoglycerate kinase activity
A6J37_RS02280	COG0445	tRNA wobble uridine modification
A6J37_RS02285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6J37_RS02295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6J37_RS02310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6J37_RS02330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J37_RS02350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6J37_RS02360	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6J37_RS02360	COG3264	Mechanosensitive ion channel
A6J37_RS02375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J37_RS02405	COG2032	superoxide dismutase activity
A6J37_RS02435	COG3279	Response regulator of the LytR AlgR family
A6J37_RS02455	COG0363	glucosamine-6-phosphate deaminase activity
A6J37_RS02475	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6J37_RS02510	COG0556	nucleotide-excision repair
A6J37_RS02525	COG3033	Beta-eliminating lyase
A6J37_RS02555	COG2304	oxidoreductase activity
A6J37_RS02565	COG1368	sulfuric ester hydrolase activity
A6J37_RS02570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6J37_RS02575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6J37_RS02580	COG1505	serine-type exopeptidase activity
A6J37_RS02600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J37_RS02610	COG0653	protein targeting
A6J37_RS02630	COG4206	TonB-dependent receptor
A6J37_RS02640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J37_RS02645	COG2153	protein acetylation
A6J37_RS02720	COG4771	TonB-dependent receptor
A6J37_RS02965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6J37_RS02975	COG2001	Belongs to the MraZ family
A6J37_RS02980	COG0275	rRNA processing
A6J37_RS02990	COG0768	penicillin binding
A6J37_RS02995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6J37_RS03000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6J37_RS03005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6J37_RS03015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6J37_RS03020	COG2827	Endonuclease containing a URI domain
A6J37_RS03025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J37_RS03045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6J37_RS03050	COG1610	YqeY-like protein
A6J37_RS03065	COG0542	response to heat
A6J37_RS03075	COG2166	iron-sulfur cluster assembly
A6J37_RS03095	COG0285	dihydrofolate synthase activity
A6J37_RS03110	COG0811	peptide transport
A6J37_RS03130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J37_RS03135	COG3118	belongs to the thioredoxin family
A6J37_RS03150	COG0433	COG0433 Predicted ATPase
A6J37_RS03155	COG2176	DNA-directed DNA polymerase activity
A6J37_RS03160	COG0019	diaminopimelate decarboxylase activity
A6J37_RS03185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6J37_RS03235	COG0606	chelatase, subunit chli
A6J37_RS03255	COG0662	Cupin 2, conserved barrel domain protein
A6J37_RS03255	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A6J37_RS03275	COG2151	metal-sulfur cluster biosynthetic enzyme
A6J37_RS03285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6J37_RS03290	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J37_RS03300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6J37_RS03310	COG2081	HI0933 family
A6J37_RS03330	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6J37_RS03340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J37_RS03345	COG2321	neutral zinc metallopeptidase
A6J37_RS03350	COG1368	sulfuric ester hydrolase activity
A6J37_RS03365	COG3409	Peptidoglycan-binding domain 1 protein
A6J37_RS03365	COG0793	Belongs to the peptidase S41A family
A6J37_RS03370	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6J37_RS03410	COG0437	4 iron, 4 sulfur cluster binding
A6J37_RS03440	COG1770	oligopeptidase
A6J37_RS03455	COG0463	Glycosyl transferase, family 2
A6J37_RS03465	COG0343	queuine tRNA-ribosyltransferase activity
A6J37_RS03480	COG0799	negative regulation of ribosome biogenesis
A6J37_RS03485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J37_RS03495	COG4589	Belongs to the CDS family
A6J37_RS03500	COG0688	phosphatidylethanolamine metabolic process
A6J37_RS03510	COG1132	(ABC) transporter
A6J37_RS03535	COG1011	Hydrolase
A6J37_RS03550	COG0738	Major facilitator superfamily
A6J37_RS03555	COG0246	Mannitol dehydrogenase
A6J37_RS03560	COG1609	Transcriptional regulator
A6J37_RS03565	COG0180	Tryptophanyl-tRNA synthetase
A6J37_RS03575	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6J37_RS03595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6J37_RS03605	COG1754	DNA topoisomerase type I activity
A6J37_RS03605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J37_RS03610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6J37_RS03620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6J37_RS03625	COG2949	membrane
A6J37_RS03665	COG1028	Short-chain dehydrogenase reductase Sdr
A6J37_RS03670	COG1312	Catalyzes the dehydration of D-mannonate
A6J37_RS03675	COG1904	glucuronate isomerase
A6J37_RS03680	COG1609	Transcriptional regulator
A6J37_RS03705	COG1595	DNA-templated transcription, initiation
A6J37_RS03715	COG1114	Component of the transport system for branched-chain amino acids
A6J37_RS03720	COG0254	rRNA binding
A6J37_RS03740	COG0300	oxidoreductase activity
A6J37_RS03750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6J37_RS03770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6J37_RS03775	COG0612	Peptidase, M16
A6J37_RS03825	COG1703	isobutyryl-CoA mutase activity
A6J37_RS03825	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6J37_RS03825	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6J37_RS03845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6J37_RS03850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6J37_RS03855	COG0052	Belongs to the universal ribosomal protein uS2 family
A6J37_RS03865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6J37_RS03870	COG0516	GMP reductase activity
A6J37_RS03870	COG0517	IMP dehydrogenase activity
A6J37_RS03875	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A6J37_RS03885	COG0825	malonyl-CoA metabolic process
A6J37_RS03890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J37_RS03895	COG1216	Glycosyl transferase, family 2
A6J37_RS03905	COG0110	maltose O-acetyltransferase activity
A6J37_RS03920	COG0463	Glycosyl transferase, family 2
A6J37_RS03930	COG0438	transferase activity, transferring glycosyl groups
A6J37_RS03930	COG4641	Protein conserved in bacteria
A6J37_RS03935	COG0463	Glycosyl transferase, family 2
A6J37_RS03940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6J37_RS03945	COG0439	Biotin carboxylase
A6J37_RS03950	COG0511	ligase activity, forming carbon-carbon bonds
A6J37_RS03955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6J37_RS03965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6J37_RS03970	COG0307	riboflavin synthase, alpha
A6J37_RS03975	COG5000	phosphorelay sensor kinase activity
A6J37_RS03980	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6J37_RS03985	COG2884	Cell division ATP-binding protein ftsE
A6J37_RS03990	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6J37_RS03995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6J37_RS04010	COG2267	carboxylic ester hydrolase activity
A6J37_RS04030	COG0791	NLP P60 protein
A6J37_RS04040	COG1519	Transferase
A6J37_RS04040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6J37_RS04050	COG0495	leucyl-tRNA aminoacylation
A6J37_RS04090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A6J37_RS04105	COG2205	protein histidine kinase activity
A6J37_RS04110	COG4771	TonB-dependent receptor
A6J37_RS04125	COG1132	(ABC) transporter
A6J37_RS04130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J37_RS04145	COG0167	dihydroorotate dehydrogenase activity
A6J37_RS04150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6J37_RS04155	COG2207	Transcriptional regulator
A6J37_RS04160	COG3655	Transcriptional regulator
A6J37_RS04180	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J37_RS04185	COG0658	competence protein
A6J37_RS04185	COG2333	competence protein COMEC
A6J37_RS04195	COG1053	succinate dehydrogenase
A6J37_RS04205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6J37_RS04220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J37_RS04235	COG0237	dephospho-CoA kinase activity
A6J37_RS04240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J37_RS04250	COG2255	four-way junction helicase activity
A6J37_RS04260	COG0010	Belongs to the arginase family
A6J37_RS04265	COG1012	belongs to the aldehyde dehydrogenase family
A6J37_RS04270	COG1115	amino acid carrier protein
A6J37_RS04285	COG0571	ribonuclease III activity
A6J37_RS04290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J37_RS04295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J37_RS04300	COG0302	gtp cyclohydrolase
A6J37_RS04305	COG0215	cysteine-tRNA ligase activity
A6J37_RS04310	COG1640	4-alpha-glucanotransferase
A6J37_RS04330	COG1528	Iron-storage protein
A6J37_RS04335	COG2986	histidine ammonia-lyase
A6J37_RS04340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6J37_RS04345	COG0861	Integral membrane protein TerC family
A6J37_RS04355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6J37_RS04365	COG0322	excinuclease ABC activity
A6J37_RS04380	COG1074	ATP-dependent DNA helicase activity
A6J37_RS04385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6J37_RS04390	COG4974	Belongs to the 'phage' integrase family
A6J37_RS04420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6J37_RS04445	COG1733	regulation of RNA biosynthetic process
A6J37_RS04455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6J37_RS04460	COG0081	regulation of translation
A6J37_RS04465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6J37_RS04470	COG0222	ribosome binding
A6J37_RS04480	COG1663	tetraacyldisaccharide 4'-kinase activity
A6J37_RS04485	COG1561	YicC-like family, N-terminal region
A6J37_RS04490	COG4106	trans-aconitate 2-methyltransferase activity
A6J37_RS04495	COG0194	GDP metabolic process
A6J37_RS04500	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6J37_RS04670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6J37_RS04680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J37_RS04690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6J37_RS04705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J37_RS04725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J37_RS04730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6J37_RS04750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6J37_RS04755	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6J37_RS04775	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6J37_RS04780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6J37_RS04795	COG0552	protein localization to endoplasmic reticulum
A6J37_RS04800	COG2261	transglycosylase associated protein
A6J37_RS04805	COG0616	signal peptide processing
A6J37_RS04810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6J37_RS04810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6J37_RS04825	COG0514	ATP-dependent DNA helicase (RecQ)
A6J37_RS04830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6J37_RS04840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J37_RS04840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J37_RS04845	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6J37_RS04850	COG1733	regulation of RNA biosynthetic process
A6J37_RS04925	COG2176	DNA-directed DNA polymerase activity
A6J37_RS04930	COG1183	phosphatidylcholine synthase activity
A6J37_RS04950	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J37_RS04950	COG0022	dehydrogenase e1 component
A6J37_RS04955	COG3158	transport of potassium into the cell
A6J37_RS04970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6J37_RS04990	COG1678	Uncharacterized ACR, COG1678
A6J37_RS04995	COG0259	pyridoxamine-phosphate oxidase activity
A6J37_RS05005	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A6J37_RS05015	COG1047	Peptidyl-prolyl cis-trans
A6J37_RS05020	COG4628	conserved protein (DUF2132)
A6J37_RS05035	COG0339	signal peptide processing
A6J37_RS05080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J37_RS05085	COG1881	PFAM PEBP family protein
A6J37_RS05110	COG2267	carboxylic ester hydrolase activity
A6J37_RS05140	COG0494	nUDIX hydrolase
A6J37_RS05190	COG0459	protein refolding
A6J37_RS05195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6J37_RS05225	COG4221	oxidoreductase activity
A6J37_RS05245	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6J37_RS05250	COG0504	CTP synthase activity
A6J37_RS05255	COG0706	membrane insertase activity
A6J37_RS05265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6J37_RS05270	COG4771	TonB-dependent receptor
A6J37_RS05280	COG1629	transport
A6J37_RS05290	COG0018	arginyl-trna synthetase
A6J37_RS05300	COG0308	aminopeptidase N
A6J37_RS05310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6J37_RS05345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J37_RS05360	COG1028	Short-chain dehydrogenase reductase Sdr
A6J37_RS05360	COG3321	synthase
A6J37_RS05360	COG0604	alcohol dehydrogenase
A6J37_RS05380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6J37_RS05420	COG0488	(ABC) transporter
A6J37_RS05430	COG2363	Small membrane protein
A6J37_RS05440	COG0045	succinate-CoA ligase (ADP-forming) activity
A6J37_RS05450	COG1196	nuclear chromosome segregation
A6J37_RS05450	COG3264	Mechanosensitive ion channel
A6J37_RS05460	COG4206	TonB-dependent receptor
A6J37_RS05465	COG0673	inositol 2-dehydrogenase activity
A6J37_RS05475	COG0813	purine-nucleoside phosphorylase activity
A6J37_RS05480	COG0488	(ABC) transporter
A6J37_RS05485	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
A6J37_RS05500	COG0336	Belongs to the RNA methyltransferase TrmD family
A6J37_RS05510	COG1522	sequence-specific DNA binding
A6J37_RS05525	COG0113	porphobilinogen synthase activity
A6J37_RS05530	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6J37_RS05540	COG0436	Aminotransferase
A6J37_RS05550	COG1704	LemA family
A6J37_RS05560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J37_RS05580	COG1160	GTP binding
A6J37_RS05590	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6J37_RS05595	COG1040	competence protein
A6J37_RS05600	COG1396	sequence-specific DNA binding
A6J37_RS05605	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6J37_RS05610	COG2224	Isocitrate lyase
A6J37_RS05625	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J37_RS05630	COG0720	synthase
A6J37_RS05635	COG4771	TonB-dependent receptor
A6J37_RS05645	COG0205	6-phosphofructokinase activity
A6J37_RS05650	COG1629	transport
A6J37_RS05660	COG3119	arylsulfatase activity
A6J37_RS05665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6J37_RS05690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J37_RS05695	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6J37_RS05700	COG1301	dicarboxylic acid transport
A6J37_RS05705	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
A6J37_RS05770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6J37_RS05775	COG1794	racemase activity, acting on amino acids and derivatives
A6J37_RS05780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6J37_RS05795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J37_RS05815	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6J37_RS05840	COG0708	Exodeoxyribonuclease III
A6J37_RS05870	COG0489	protein tyrosine kinase activity
A6J37_RS05875	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6J37_RS05880	COG4774	siderophore transport
A6J37_RS05885	COG0248	Ppx GppA phosphatase
A6J37_RS05890	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6J37_RS05895	COG0443	Heat shock 70 kDa protein
A6J37_RS05950	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6J37_RS05950	COG0284	orotidine-5'-phosphate decarboxylase activity
A6J37_RS05955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J37_RS05970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6J37_RS05975	COG0242	peptide deformylase activity
A6J37_RS05985	COG3956	TIGRFAM MazG family protein
A6J37_RS05990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J37_RS05995	COG2936	dipeptidyl-peptidase activity
A6J37_RS06035	COG1007	ATP synthesis coupled electron transport
A6J37_RS06040	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J37_RS06045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6J37_RS06050	COG0713	ATP synthesis coupled electron transport
A6J37_RS06055	COG0839	Belongs to the complex I subunit 6 family
A6J37_RS06060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J37_RS06065	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6J37_RS06070	COG1034	ATP synthesis coupled electron transport
A6J37_RS06080	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A6J37_RS06090	COG0649	NAD binding
A6J37_RS06095	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J37_RS06100	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J37_RS06105	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J37_RS06130	COG0356	it plays a direct role in the translocation of protons across the membrane
A6J37_RS06135	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6J37_RS06140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6J37_RS06145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6J37_RS06150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6J37_RS06155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6J37_RS06165	COG1253	flavin adenine dinucleotide binding
A6J37_RS06170	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6J37_RS06185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J37_RS06205	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6J37_RS06210	COG0528	UMP kinase activity
A6J37_RS06215	COG0233	cytoplasmic translational termination
A6J37_RS06220	COG3119	arylsulfatase activity
A6J37_RS06245	COG4771	TonB-dependent receptor
A6J37_RS06260	COG1063	alcohol dehydrogenase
A6J37_RS06330	COG3621	Patatin-like phospholipase
A6J37_RS06335	COG1876	peptidase activity
A6J37_RS06365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J37_RS06365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J37_RS06395	COG3279	Response regulator of the LytR AlgR family
A6J37_RS06405	COG1024	Enoyl-CoA hydratase
A6J37_RS06405	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6J37_RS06410	COG4716	Myosin-crossreactive antigen
A6J37_RS06430	COG0471	metal ion transport
A6J37_RS06440	COG1053	succinate dehydrogenase
A6J37_RS06445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6J37_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
A6J37_RS06475	COG0038	chloride channel
A6J37_RS06505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J37_RS06510	COG2207	Transcriptional regulator
A6J37_RS06525	COG1309	transcriptional regulator
A6J37_RS06530	COG0183	Belongs to the thiolase family
A6J37_RS06540	COG0183	Belongs to the thiolase family
A6J37_RS06550	COG0494	nUDIX hydrolase
A6J37_RS06555	COG0561	phosphatase activity
A6J37_RS06575	COG1131	(ABC) transporter
A6J37_RS06580	COG3655	Transcriptional regulator
A6J37_RS06590	COG1960	acyl-CoA dehydrogenase activity
A6J37_RS06605	COG3541	Predicted nucleotidyltransferase
A6J37_RS06650	COG1858	cytochrome C peroxidase
A6J37_RS06685	COG0038	chloride channel
A6J37_RS06720	COG0659	secondary active sulfate transmembrane transporter activity
A6J37_RS06745	COG1733	regulation of RNA biosynthetic process
A6J37_RS06750	COG2814	Major facilitator Superfamily
A6J37_RS06760	COG2807	transmembrane transport
A6J37_RS06815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J37_RS06825	COG0156	8-amino-7-oxononanoate synthase activity
A6J37_RS06830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6J37_RS06835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6J37_RS06840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6J37_RS06845	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6J37_RS06850	COG1959	2 iron, 2 sulfur cluster binding
A6J37_RS06865	COG4654	Cytochrome c, class I
A6J37_RS06870	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A6J37_RS06905	COG1538	Outer membrane efflux protein
A6J37_RS06925	COG4206	TonB-dependent receptor
A6J37_RS06925	COG1629	transport
A6J37_RS06935	COG2610	gluconate transmembrane transporter activity
A6J37_RS06950	COG0800	Aldolase
A6J37_RS06965	COG1349	DNA-binding transcription factor activity
A6J37_RS06970	COG2274	protein secretion by the type I secretion system
A6J37_RS06995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J37_RS07040	COG2706	6-phosphogluconolactonase activity
A6J37_RS07095	COG1401	restriction endodeoxyribonuclease activity
A6J37_RS07190	COG4974	Belongs to the 'phage' integrase family
A6J37_RS07205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6J37_RS07210	COG0006	proline dipeptidase activity
A6J37_RS07215	COG1012	belongs to the aldehyde dehydrogenase family
A6J37_RS07225	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6J37_RS07230	COG3118	belongs to the thioredoxin family
A6J37_RS07245	COG3876	Protein conserved in bacteria
A6J37_RS07265	COG4145	pantothenate transmembrane transporter activity
A6J37_RS07275	COG0402	S-adenosylhomocysteine deaminase activity
A6J37_RS07285	COG0666	response to abiotic stimulus
A6J37_RS07290	COG0402	S-adenosylhomocysteine deaminase activity
A6J37_RS07295	COG0456	acetyltransferase
A6J37_RS07310	COG0367	asparagine synthase
A6J37_RS07320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J37_RS07320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J37_RS07325	COG2824	Alkylphosphonate utilization operon protein PhnA
A6J37_RS07345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6J37_RS07355	COG0492	ferredoxin-NADP+ reductase activity
A6J37_RS07380	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J37_RS07395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6J37_RS07420	COG1674	ftsk spoiiie
A6J37_RS07425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J37_RS07425	COG1333	cytochrome c biogenesis protein
A6J37_RS07470	COG1011	Hydrolase
A6J37_RS07490	COG0492	ferredoxin-NADP+ reductase activity
A6J37_RS07520	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A6J37_RS07530	COG3621	Patatin-like phospholipase
A6J37_RS07565	COG4206	TonB-dependent receptor
A6J37_RS07565	COG1629	transport
A6J37_RS07605	COG0732	type I restriction modification DNA specificity domain
A6J37_RS07615	COG4974	Belongs to the 'phage' integrase family
A6J37_RS07635	COG1309	transcriptional regulator
A6J37_RS07640	COG1309	transcriptional regulator
A6J37_RS07710	COG0351	phosphomethylpyrimidine kinase
A6J37_RS07710	COG0352	thiamine-phosphate diphosphorylase activity
A6J37_RS07715	COG0352	thiamine-phosphate diphosphorylase activity
A6J37_RS07720	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A6J37_RS07730	COG3279	Response regulator of the LytR AlgR family
A6J37_RS07735	COG0475	glutathione-regulated potassium exporter activity
A6J37_RS07755	COG4977	sequence-specific DNA binding
A6J37_RS07755	COG1917	Cupin 2, conserved barrel domain protein
A6J37_RS07775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J37_RS07785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J37_RS07820	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6J37_RS07825	COG1027	Aspartate ammonia-lyase
A6J37_RS07830	COG0612	Peptidase, M16
A6J37_RS07835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6J37_RS07840	COG1472	Belongs to the glycosyl hydrolase 3 family
A6J37_RS07845	COG4717	serine-type aminopeptidase activity
A6J37_RS07870	COG2205	protein histidine kinase activity
A6J37_RS07880	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A6J37_RS07890	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A6J37_RS07900	COG2204	response regulator
A6J37_RS07905	COG2217	Heavy metal translocating P-type atpase
A6J37_RS07910	COG3279	Response regulator of the LytR AlgR family
A6J37_RS07915	COG2972	Histidine kinase
A6J37_RS07940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6J37_RS07950	COG2272	Belongs to the type-B carboxylesterase lipase family
A6J37_RS07960	COG0300	oxidoreductase activity
A6J37_RS07965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6J37_RS07975	COG1131	(ABC) transporter
A6J37_RS07980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J37_RS07990	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6J37_RS08000	COG0586	Pfam SNARE associated Golgi protein
A6J37_RS08005	COG0358	DNA primase activity
A6J37_RS08035	COG0697	spore germination
A6J37_RS08040	COG1522	sequence-specific DNA binding
A6J37_RS08045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6J37_RS08080	COG0149	triose-phosphate isomerase activity
A6J37_RS08085	COG2264	protein methyltransferase activity
A6J37_RS08095	COG0739	heme binding
A6J37_RS08100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6J37_RS08105	COG0579	oxidoreductase
A6J37_RS08115	COG2271	Major facilitator Superfamily
A6J37_RS08120	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A6J37_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
A6J37_RS08140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J37_RS08145	COG1085	galactose-1-phosphate uridylyltransferase
A6J37_RS08150	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6J37_RS08155	COG2017	converts alpha-aldose to the beta-anomer
A6J37_RS08180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6J37_RS08210	COG1566	PFAM secretion protein HlyD family protein
A6J37_RS08225	COG1446	asparaginase
A6J37_RS08240	COG2755	lipolytic protein G-D-S-L family
A6J37_RS08260	COG1506	peptidase
A6J37_RS08260	COG0823	Involved in the tonB-independent uptake of proteins
A6J37_RS08270	COG3104	oligopeptide transport
A6J37_RS08280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J37_RS08285	COG4771	TonB-dependent receptor
A6J37_RS08290	COG3361	conserved protein (COG2071)
A6J37_RS08295	COG0617	tRNA 3'-terminal CCA addition
A6J37_RS08295	COG0517	IMP dehydrogenase activity
A6J37_RS08295	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6J37_RS08300	COG0009	L-threonylcarbamoyladenylate synthase
A6J37_RS08305	COG0626	cystathionine gamma-synthase activity
A6J37_RS08325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6J37_RS08335	COG2732	(Barnase) inhibitor
A6J37_RS08350	COG0745	RESPONSE REGULATOR receiver
A6J37_RS08355	COG5002	protein histidine kinase activity
A6J37_RS08385	COG0596	Alpha beta hydrolase
A6J37_RS08400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6J37_RS08415	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6J37_RS08445	COG1058	Belongs to the CinA family
A6J37_RS08445	COG1546	Belongs to the CinA family
A6J37_RS08455	COG3590	peptidase
A6J37_RS08470	COG3590	peptidase
A6J37_RS08480	COG2234	aminopeptidase activity
A6J37_RS08505	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A6J37_RS08510	COG0427	acetyl-CoA hydrolase
A6J37_RS08520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J37_RS08535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J37_RS08545	COG2268	Band 7 protein
A6J37_RS08560	COG1530	ribonuclease E activity
A6J37_RS08565	COG0776	regulation of translation
A6J37_RS08570	COG1194	a g-specific adenine glycosylase
A6J37_RS08585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J37_RS08635	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A6J37_RS08640	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6J37_RS08645	COG0612	Peptidase, M16
A6J37_RS08650	COG0612	Peptidase, M16
A6J37_RS08660	COG2378	regulation of single-species biofilm formation
A6J37_RS08670	COG3781	membrane
A6J37_RS08675	COG2814	Major facilitator Superfamily
A6J37_RS08695	COG2353	YceI-like domain
A6J37_RS08700	COG3384	dioxygenase
A6J37_RS08705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J37_RS08730	COG2169	Transcriptional regulator
A6J37_RS08730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J37_RS08745	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A6J37_RS08755	COG0730	response to heat
A6J37_RS08780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6J37_RS08780	COG0140	phosphoribosyl-ATP diphosphatase activity
A6J37_RS08785	COG0107	imidazoleglycerol-phosphate synthase activity
A6J37_RS08810	COG0131	Imidazoleglycerol-phosphate dehydratase
A6J37_RS08820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6J37_RS08825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6J37_RS08830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6J37_RS08835	COG0477	Major facilitator Superfamily
A6J37_RS08840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J37_RS08845	COG1741	Belongs to the pirin family
A6J37_RS08880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6J37_RS08895	COG1702	phosphate starvation-inducible protein PhoH
A6J37_RS08925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6J37_RS08940	COG0592	DNA-directed DNA polymerase activity
A6J37_RS08960	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6J37_RS08980	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6J37_RS08995	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A6J37_RS09005	COG4574	serine-type endopeptidase inhibitor activity
A6J37_RS09020	COG0405	Gamma-glutamyltransferase
A6J37_RS09025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J37_RS09040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J37_RS09050	COG2226	methyltransferase
A6J37_RS09065	COG1418	mRNA catabolic process
A6J37_RS09085	COG1335	isochorismatase
A6J37_RS09115	COG3345	alpha-galactosidase
A6J37_RS09135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J37_RS09135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J37_RS09140	COG0463	Glycosyl transferase, family 2
A6J37_RS09140	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A6J37_RS09165	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A6J37_RS09170	COG4677	pectinesterase activity
A6J37_RS09175	COG1464	Belongs to the NlpA lipoprotein family
A6J37_RS09180	COG2011	ABC-type metal ion transport system permease component
A6J37_RS09195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J37_RS09215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A6J37_RS09220	COG0563	adenylate kinase activity
A6J37_RS09225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6J37_RS09230	COG0513	Belongs to the DEAD box helicase family
A6J37_RS09235	COG0084	hydrolase, TatD family'
A6J37_RS09250	COG0306	phosphate transporter
A6J37_RS09265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J37_RS09270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6J37_RS09280	COG1192	Involved in chromosome partitioning
A6J37_RS09285	COG1475	DNA binding
A6J37_RS09295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6J37_RS09300	COG0681	Belongs to the peptidase S26 family
A6J37_RS09320	COG2885	chlorophyll binding
A6J37_RS09325	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6J37_RS09370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J37_RS09380	COG2197	response regulator
A6J37_RS09450	COG0542	response to heat
A6J37_RS09505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J37_RS09525	COG0596	Alpha beta hydrolase
A6J37_RS09550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J37_RS09555	COG0697	spore germination
A6J37_RS09560	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6J37_RS09570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J37_RS09580	COG3708	Transcriptional regulator
A6J37_RS09615	COG1064	alcohol dehydrogenase
A6J37_RS09630	COG1028	Short-chain dehydrogenase reductase Sdr
A6J37_RS09645	COG1999	signal sequence binding
A6J37_RS09650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6J37_RS09655	COG1234	tRNA 3'-trailer cleavage
A6J37_RS09660	COG2814	Major facilitator Superfamily
A6J37_RS09695	COG2194	sulfuric ester hydrolase activity
A6J37_RS09715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J37_RS09715	COG2207	Transcriptional regulator
A6J37_RS09720	COG0348	domain, Protein
A6J37_RS09740	COG2076	Multidrug Resistance protein
A6J37_RS09745	COG1785	Belongs to the alkaline phosphatase family
A6J37_RS09755	COG1733	regulation of RNA biosynthetic process
A6J37_RS09760	COG1733	regulation of RNA biosynthetic process
A6J37_RS09770	COG0778	Nitroreductase
A6J37_RS09780	COG2207	Transcriptional regulator
A6J37_RS09800	COG3275	phosphorelay sensor kinase activity
A6J37_RS09805	COG3279	Response regulator of the LytR AlgR family
A6J37_RS09810	COG2957	Belongs to the agmatine deiminase family
A6J37_RS09825	COG0431	NADPH-dependent FMN reductase
A6J37_RS09865	COG1028	Short-chain dehydrogenase reductase Sdr
A6J37_RS09875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J37_RS09935	COG2197	response regulator
A6J37_RS09940	COG0415	Belongs to the DNA photolyase family
A6J37_RS09965	COG1028	Short-chain dehydrogenase reductase Sdr
A6J37_RS09970	COG0519	Catalyzes the synthesis of GMP from XMP
A6J37_RS10035	COG0024	Methionine aminopeptidase
A6J37_RS10040	COG0242	peptide deformylase activity
A6J37_RS10050	COG0656	L-ascorbic acid biosynthetic process
A6J37_RS10055	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6J37_RS10065	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6J37_RS10125	COG3781	membrane
A6J37_RS10170	COG4771	TonB-dependent receptor
A6J37_RS10245	COG0523	cobalamin synthesis protein
A6J37_RS10260	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A6J37_RS10280	COG2207	Transcriptional regulator
A6J37_RS10280	COG0662	Cupin 2, conserved barrel domain protein
A6J37_RS10285	COG2375	cellular response to nickel ion
A6J37_RS10290	COG0534	Mate efflux family protein
A6J37_RS10305	COG1611	Belongs to the LOG family
A6J37_RS10325	COG0456	acetyltransferase
A6J37_RS10330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6J37_RS10350	COG1309	transcriptional regulator
A6J37_RS10395	COG1764	response to oxidative stress
A6J37_RS10400	COG1846	Transcriptional regulator
A6J37_RS10415	COG3781	membrane
A6J37_RS10420	COG0025	NhaP-type Na H and K H
A6J37_RS10430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6J37_RS10460	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6J37_RS10470	COG1289	transmembrane transporter activity
A6J37_RS10480	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J37_RS10485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J37_RS10520	COG0598	Magnesium transport protein CorA
A6J37_RS10525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J37_RS10535	COG3537	Alpha-1,2-mannosidase
A6J37_RS10540	COG0583	DNA-binding transcription factor activity
A6J37_RS10545	COG2814	Major facilitator Superfamily
A6J37_RS10550	COG1902	pentaerythritol trinitrate reductase activity
A6J37_RS10555	COG0667	Aldo Keto reductase
A6J37_RS10595	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6J37_RS10605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J37_RS10620	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J37_RS10625	COG2967	ApaG domain
A6J37_RS10630	COG0697	spore germination
A6J37_RS10665	COG2133	pyrroloquinoline quinone binding
A6J37_RS10670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6J37_RS10685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6J37_RS10695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6J37_RS10700	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6J37_RS10705	COG1629	transport
A6J37_RS10705	COG4206	TonB-dependent receptor
A6J37_RS10710	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6J37_RS10725	COG1082	Xylose isomerase domain protein TIM barrel
A6J37_RS10735	COG1741	Belongs to the pirin family
A6J37_RS10745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6J37_RS10750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6J37_RS10765	COG0151	Belongs to the GarS family
A6J37_RS10770	COG0519	Catalyzes the synthesis of GMP from XMP
A6J37_RS10770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6J37_RS10775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6J37_RS10780	COG0513	Belongs to the DEAD box helicase family
A6J37_RS10800	COG1979	alcohol dehydrogenase
A6J37_RS10820	COG3153	acetyltransferase
A6J37_RS10825	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6J37_RS10845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J37_RS10850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6J37_RS10885	COG2003	Belongs to the UPF0758 family
A6J37_RS10890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6J37_RS10895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6J37_RS10900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6J37_RS10910	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A6J37_RS10910	COG1605	Chorismate mutase
A6J37_RS10920	COG1131	(ABC) transporter
A6J37_RS10940	COG1187	pseudouridine synthase activity
A6J37_RS10955	COG1335	isochorismatase
A6J37_RS10965	COG3118	belongs to the thioredoxin family
A6J37_RS10975	COG0242	peptide deformylase activity
A6J37_RS11000	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A6J37_RS11005	COG1363	Peptidase, m42
A6J37_RS11025	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6J37_RS11025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J37_RS11030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J37_RS11045	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J37_RS11050	COG3022	response to hydroperoxide
A6J37_RS11055	COG0009	L-threonylcarbamoyladenylate synthase
A6J37_RS11080	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6J37_RS11085	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A6J37_RS11115	COG1970	mechanosensitive ion channel activity
A6J37_RS11120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6J37_RS11130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6J37_RS11135	COG0077	Prephenate dehydratase
A6J37_RS11155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J37_RS11165	COG0505	Belongs to the CarA family
A6J37_RS11195	COG0583	DNA-binding transcription factor activity
A6J37_RS11200	COG2855	membrane
A6J37_RS11305	COG1012	belongs to the aldehyde dehydrogenase family
A6J37_RS11340	COG0791	NLP P60 protein
A6J37_RS11345	COG2171	N-acyltransferase activity
A6J37_RS11355	COG0463	Glycosyl transferase, family 2
A6J37_RS11385	COG0159	tryptophan synthase activity
A6J37_RS11390	COG0133	tryptophan synthase activity
A6J37_RS11395	COG0135	phosphoribosylanthranilate isomerase activity
A6J37_RS11400	COG0134	indole-3-glycerol-phosphate synthase activity
A6J37_RS11405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6J37_RS11410	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J37_RS11415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6J37_RS11425	COG0531	amino acid
A6J37_RS11475	COG0314	molybdopterin synthase activity
A6J37_RS11480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6J37_RS11500	COG3781	membrane
A6J37_RS11515	COG0746	molybdenum cofactor guanylyltransferase activity
A6J37_RS11530	COG0303	'Molybdopterin
A6J37_RS11595	COG1217	gtp-binding protein TYPA
A6J37_RS11605	COG0531	amino acid
A6J37_RS11620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J37_RS11635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J37_RS11650	COG0671	phosphoesterase, PA-phosphatase related
A6J37_RS11660	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6J37_RS11665	COG1295	ribonuclease BN
A6J37_RS11690	COG0295	cytidine deaminase activity
A6J37_RS11695	COG4206	TonB-dependent receptor
A6J37_RS11695	COG1629	transport
A6J37_RS11740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J37_RS11745	COG3938	Belongs to the proline racemase family
A6J37_RS11755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J37_RS11760	COG2207	Transcriptional regulator
A6J37_RS11765	COG0006	proline dipeptidase activity
A6J37_RS11770	COG1506	peptidase
A6J37_RS11770	COG0823	Involved in the tonB-independent uptake of proteins
A6J37_RS11770	COG4946	Tricorn protease homolog
A6J37_RS11775	COG1595	DNA-templated transcription, initiation
A6J37_RS11790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6J37_RS11795	COG3340	Belongs to the peptidase S51 family
A6J37_RS11805	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6J37_RS11810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6J37_RS11815	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6J37_RS11850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6J37_RS11855	COG1234	tRNA 3'-trailer cleavage
A6J37_RS11865	COG0670	Belongs to the BI1 family
A6J37_RS11880	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A6J37_RS11895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6J37_RS11900	COG2177	Part of the ABC transporter FtsEX involved in
A6J37_RS11910	COG1968	undecaprenyl-diphosphatase activity
A6J37_RS11920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6J37_RS11960	COG1960	acyl-CoA dehydrogenase activity
A6J37_RS11965	COG0183	Belongs to the thiolase family
A6J37_RS11975	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6J37_RS11975	COG1024	Enoyl-CoA hydratase
A6J37_RS11985	COG1120	ATPase activity
A6J37_RS11995	COG3118	belongs to the thioredoxin family
A6J37_RS12005	COG2949	membrane
A6J37_RS12025	COG0572	uridine kinase
A6J37_RS12055	COG1028	Short-chain dehydrogenase reductase Sdr
A6J37_RS12065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A6J37_RS12075	COG2211	Major facilitator Superfamily
A6J37_RS12090	COG1446	asparaginase
A6J37_RS12100	COG1629	transport
A6J37_RS12105	COG0702	epimerase
A6J37_RS12110	COG0460	homoserine dehydrogenase
A6J37_RS12110	COG0527	aspartate kinase activity
A6J37_RS12115	COG0083	homoserine kinase activity
A6J37_RS12120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6J37_RS12130	COG0183	Belongs to the thiolase family
A6J37_RS12135	COG2270	Major facilitator Superfamily
A6J37_RS12140	COG0105	UTP biosynthetic process
A6J37_RS12150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6J37_RS12155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6J37_RS12185	COG1803	Methylglyoxal synthase
A6J37_RS12210	COG0450	alkyl hydroperoxide reductase
A6J37_RS12215	COG0612	Peptidase, M16
A6J37_RS12220	COG0436	Aminotransferase
A6J37_RS12225	COG0357	Ribosomal RNA small subunit methyltransferase G
A6J37_RS12245	COG0012	GTP binding
A6J37_RS12255	COG0436	Aminotransferase
A6J37_RS12280	COG1280	lysine exporter protein (LysE YggA)
A6J37_RS12285	COG3012	SEC-C Motif Domain Protein
A6J37_RS12305	COG1960	acyl-CoA dehydrogenase activity
A6J37_RS12315	COG4977	sequence-specific DNA binding
A6J37_RS12320	COG2211	Major facilitator Superfamily
A6J37_RS12325	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A6J37_RS12330	COG0076	glutamate decarboxylase activity
A6J37_RS12335	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A6J37_RS12355	COG1131	(ABC) transporter
A6J37_RS12375	COG0346	lactoylglutathione lyase activity
A6J37_RS12380	COG0431	NADPH-dependent FMN reductase
A6J37_RS12445	COG3279	Response regulator of the LytR AlgR family
A6J37_RS12465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J37_RS12475	COG1538	Outer membrane efflux protein
A6J37_RS12540	COG0210	DNA helicase
A6J37_RS12560	COG3279	Response regulator of the LytR AlgR family
A6J37_RS12570	COG0187	DNA topoisomerase II activity
A6J37_RS12575	COG1271	oxidase subunit
A6J37_RS12620	COG2814	Major facilitator Superfamily
A6J37_RS12630	COG0667	Aldo Keto reductase
A6J37_RS12640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6J37_RS12650	COG4654	Cytochrome c, class I
A6J37_RS12670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J37_RS12695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J37_RS12710	COG1113	amino acid transport
A6J37_RS12720	COG0488	(ABC) transporter
A6J37_RS12730	COG1506	peptidase
A6J37_RS12740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6J37_RS12745	COG2226	methyltransferase
A6J37_RS12765	COG0456	acetyltransferase
A6J37_RS12770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6J37_RS12780	COG0813	purine-nucleoside phosphorylase activity
A6J37_RS12795	COG0519	Catalyzes the synthesis of GMP from XMP
A6J37_RS12815	COG1321	iron dependent repressor
A6J37_RS12840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J37_RS12845	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6J37_RS12850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J37_RS12870	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6J37_RS12875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J37_RS12885	COG0022	dehydrogenase e1 component
A6J37_RS12900	COG2197	response regulator
A6J37_RS12920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6J37_RS12925	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6J37_RS12945	COG0156	8-amino-7-oxononanoate synthase activity
A6J37_RS12950	COG2027	D-alanyl-D-alanine carboxypeptidase
A6J37_RS12955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6J37_RS12965	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6J37_RS12985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J37_RS12985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J37_RS13005	COG1566	PFAM secretion protein HlyD family protein
A6J37_RS13020	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A6J37_RS13035	COG1960	acyl-CoA dehydrogenase activity
A6J37_RS13040	COG1022	Amp-dependent synthetase and ligase
A6J37_RS13050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6J37_RS13060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6J37_RS13100	COG0534	Mate efflux family protein
A6J37_RS13115	COG3153	acetyltransferase
A6J37_RS13115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6J37_RS13140	COG0745	RESPONSE REGULATOR receiver
A6J37_RS13145	COG0321	lipoyl(octanoyl) transferase activity
A6J37_RS13150	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J37_RS13180	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A6J37_RS13205	COG0360	Binds together with S18 to 16S ribosomal RNA
A6J37_RS13210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6J37_RS13215	COG0359	binds to the 23S rRNA
A6J37_RS13230	COG0069	glutamate synthase activity
A6J37_RS13235	COG1607	acyl-coa hydrolase
A6J37_RS13250	COG2217	Heavy metal translocating P-type atpase
A6J37_RS13270	COG2027	D-alanyl-D-alanine carboxypeptidase
A6J37_RS13275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J37_RS13280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J37_RS13290	COG1506	peptidase
A6J37_RS13290	COG0823	Involved in the tonB-independent uptake of proteins
A6J37_RS13300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6J37_RS13305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J37_RS13325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J37_RS13335	COG3511	phospholipase C
A6J37_RS13345	COG0702	epimerase
A6J37_RS13355	COG1349	DNA-binding transcription factor activity
A6J37_RS13365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6J37_RS13370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J37_RS13390	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A6J37_RS13420	COG0124	histidyl-tRNA synthetase
A6J37_RS13425	COG0629	single-stranded DNA binding
A6J37_RS13435	COG0745	RESPONSE REGULATOR receiver
A6J37_RS13455	COG0028	Belongs to the TPP enzyme family
A6J37_RS13525	COG2207	Transcriptional regulator
A6J37_RS13545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J37_RS13550	COG0563	adenylate kinase activity
A6J37_RS13575	COG0335	large ribosomal subunit rRNA binding
A6J37_RS13580	COG0494	nUDIX hydrolase
A6J37_RS13585	COG2207	Transcriptional regulator
A6J37_RS13590	COG2814	Major facilitator Superfamily
A6J37_RS13600	COG0477	Major facilitator Superfamily
A6J37_RS13605	COG0004	ammonium transporteR
A6J37_RS13620	COG0539	negative regulation of cytoplasmic translation
A6J37_RS13620	COG2183	response to ionizing radiation
A6J37_RS13625	COG0513	Belongs to the DEAD box helicase family
A6J37_RS13675	COG1119	ATPase activity
A6J37_RS13680	COG1960	acyl-CoA dehydrogenase activity
A6J37_RS13705	COG0066	3-isopropylmalate dehydratase activity
A6J37_RS13710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6J37_RS13715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6J37_RS13725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6J37_RS13730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6J37_RS13735	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6J37_RS13740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6J37_RS13745	COG0673	inositol 2-dehydrogenase activity
A6J37_RS13765	COG3275	phosphorelay sensor kinase activity
A6J37_RS13770	COG3279	Response regulator of the LytR AlgR family
A6J37_RS13780	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6J37_RS13795	COG0070	glutamate synthase
A6J37_RS13795	COG0069	glutamate synthase activity
A6J37_RS13795	COG0067	glutamate synthase
A6J37_RS13800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6J37_RS13800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6J37_RS13815	COG0724	RNA recognition motif
A6J37_RS13825	COG0514	ATP-dependent DNA helicase (RecQ)
A6J37_RS13830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6J37_RS13830	COG0517	IMP dehydrogenase activity
A6J37_RS13835	COG0805	protein transport
A6J37_RS13850	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6J37_RS13860	COG2076	Multidrug Resistance protein
A6J37_RS13880	COG0156	8-amino-7-oxononanoate synthase activity
A6J37_RS13900	COG1696	Membrane protein involved in D-alanine export
A6J37_RS13920	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6J37_RS13925	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6J37_RS13930	COG0196	riboflavin kinase activity
A6J37_RS13950	COG0386	Belongs to the glutathione peroxidase family
A6J37_RS13960	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6J37_RS13975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J37_RS14000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A6J37_RS14010	COG1575	Belongs to the MenA family. Type 1 subfamily
A6J37_RS14025	COG2706	6-phosphogluconolactonase activity
A6J37_RS14035	COG0531	amino acid
A6J37_RS14050	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6J37_RS14055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6J37_RS14135	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A6J37_RS14140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6J37_RS14160	COG1428	Deoxynucleoside kinase
A6J37_RS14165	COG1733	regulation of RNA biosynthetic process
A6J37_RS14180	COG2837	iron assimilation
A6J37_RS14230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6J37_RS14245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J37_RS14255	COG1629	transport
A6J37_RS14275	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6J37_RS14280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6J37_RS14285	COG0363	glucosamine-6-phosphate deaminase activity
A6J37_RS14325	COG2207	Transcriptional regulator
A6J37_RS14345	COG2910	NAD(P)H-binding
A6J37_RS14365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J37_RS14410	COG0022	dehydrogenase e1 component
A6J37_RS14420	COG1473	amidohydrolase
A6J37_RS14430	COG1028	Short-chain dehydrogenase reductase Sdr
A6J37_RS14440	COG0463	Glycosyl transferase, family 2
A6J37_RS14440	COG1216	Glycosyl transferase, family 2
A6J37_RS14445	COG0116	Belongs to the methyltransferase superfamily
A6J37_RS14475	COG0442	prolyl-tRNA aminoacylation
A6J37_RS14495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6J37_RS14500	COG0484	heat shock protein binding
A6J37_RS14510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A6J37_RS14515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J37_RS14550	COG4974	Belongs to the 'phage' integrase family
A6J37_RS14555	COG0582	viral genome integration into host DNA
A6J37_RS14750	COG2217	Heavy metal translocating P-type atpase
A6J37_RS14775	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J37_RS14800	COG2217	Heavy metal translocating P-type atpase
A6J37_RS14825	COG2132	Multicopper oxidase
A6J37_RS14860	COG0798	PFAM Bile acid sodium symporter
A6J37_RS14870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J37_RS14870	COG0551	DNA topoisomerase type I activity
A6J37_RS14935	COG2723	6-phospho-beta-galactosidase activity
A6J37_RS14950	COG2217	Heavy metal translocating P-type atpase
A6J37_RS14970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J37_RS14990	COG2814	Major facilitator Superfamily
A6J37_RS15000	COG2755	lipolytic protein G-D-S-L family
A6J37_RS15000	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6J37_RS15010	COG3548	integral membrane protein
A6J37_RS15025	COG1595	DNA-templated transcription, initiation
A6J37_RS15030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J37_RS15035	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6J37_RS15050	COG0823	Involved in the tonB-independent uptake of proteins
A6J37_RS15075	COG0730	response to heat
A6J37_RS15085	COG1764	response to oxidative stress
A6J37_RS15090	COG0798	PFAM Bile acid sodium symporter
A6J37_RS15145	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6J37_RS15160	COG1028	Short-chain dehydrogenase reductase Sdr
A6J37_RS15170	COG4771	TonB-dependent receptor
A6J37_RS15195	COG0745	RESPONSE REGULATOR receiver
A6J37_RS15200	COG5002	protein histidine kinase activity
A6J37_RS15205	COG0456	acetyltransferase
A6J37_RS15210	COG5006	permease, DMT superfamily
A6J37_RS15215	COG0456	acetyltransferase
A6J37_RS15240	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A6J37_RS15265	COG1285	pathogenesis
A6J37_RS15295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6J37_RS15300	COG2022	thiamine diphosphate biosynthetic process
A6J37_RS15305	COG0352	thiamine-phosphate diphosphorylase activity
A6J37_RS15325	COG1446	asparaginase
A6J37_RS15330	COG4152	abc transporter atp-binding protein
A6J37_RS15345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6J37_RS15350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J37_RS15355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6J37_RS15360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J37_RS15365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J37_RS15365	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6J37_RS15370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J37_RS15375	COG1078	dGTPase activity
A6J37_RS15395	COG0686	Belongs to the AlaDH PNT family
A6J37_RS15405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6J37_RS15410	COG0287	Prephenate dehydrogenase
A6J37_RS15425	COG1760	l-serine dehydratase
A6J37_RS15445	COG0837	glucose binding
A6J37_RS15465	COG1185	polyribonucleotide nucleotidyltransferase activity
A6J37_RS15475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6J37_RS15485	COG2239	Acts as a magnesium transporter
A6J37_RS15495	COG3813	Protein conserved in bacteria
A6J37_RS15510	COG0321	lipoyl(octanoyl) transferase activity
A6J37_RS15510	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6J37_RS15535	COG0477	Major facilitator Superfamily
A6J37_RS15545	COG0527	aspartate kinase activity
A6J37_RS15565	COG0546	phosphoglycolate phosphatase activity
A6J37_RS15605	COG3279	Response regulator of the LytR AlgR family
A6J37_RS15610	COG3275	phosphorelay sensor kinase activity
A6J37_RS15630	COG3781	membrane
A6J37_RS15710	COG1063	alcohol dehydrogenase
A6J37_RS15720	COG3119	arylsulfatase activity
A6J37_RS15730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6J37_RS15740	COG3720	iron ion transport
A6J37_RS15750	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6J37_RS15755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J37_RS15765	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6J37_RS15785	COG0577	efflux transmembrane transporter activity
A6J37_RS15805	COG0577	efflux transmembrane transporter activity
A6J37_RS15805	COG1136	(ABC) transporter
A6J37_RS15810	COG1136	(ABC) transporter
A6J37_RS15830	COG2204	response regulator
A6J37_RS15835	COG3852	Histidine kinase
A6J37_RS15840	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6J37_RS15880	COG2207	Transcriptional regulator
A6J37_RS15880	COG4753	response regulator
A6J37_RS15895	COG2207	Transcriptional regulator
A6J37_RS15895	COG4753	response regulator
A6J37_RS15930	COG4290	ribonuclease
A6J37_RS15945	COG1024	Enoyl-CoA hydratase
A6J37_RS15975	COG2814	Major facilitator Superfamily
A6J37_RS15990	COG1757	Na H antiporter
A6J37_RS15995	COG0667	Aldo Keto reductase
A6J37_RS16005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6J37_RS16020	COG1739	Uncharacterized protein family UPF0029
A6J37_RS16025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J37_RS16025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J37_RS16035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6J37_RS16045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6J37_RS16050	COG0346	lactoylglutathione lyase activity
A6J37_RS16080	COG2909	trisaccharide binding
A6J37_RS16105	COG0589	response to stress
A6J37_RS16120	COG0025	NhaP-type Na H and K H
A6J37_RS16175	COG1846	Transcriptional regulator
A6J37_RS16175	COG0456	acetyltransferase
A6J37_RS16225	COG3634	alkyl hydroperoxide reductase activity
A6J37_RS16350	COG0527	aspartate kinase activity
A6J37_RS16355	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6J37_RS16375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J37_RS16390	COG0492	ferredoxin-NADP+ reductase activity
A6J37_RS16405	COG1301	dicarboxylic acid transport
A6J37_RS16410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J37_RS16430	COG1012	belongs to the aldehyde dehydrogenase family
A6J37_RS16455	COG0612	Peptidase, M16
A6J37_RS16460	COG3425	synthase
A6J37_RS16470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6J37_RS16480	COG0697	spore germination
A6J37_RS16485	COG1187	pseudouridine synthase activity
A6J37_RS16490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6J37_RS16505	COG0346	lactoylglutathione lyase activity
A6J37_RS16525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J37_RS16535	COG1022	Amp-dependent synthetase and ligase
A6J37_RS16545	COG2267	carboxylic ester hydrolase activity
A6J37_RS16555	COG0668	transmembrane transport
A6J37_RS16590	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6J37_RS16595	COG5492	domain, Protein
A6J37_RS16605	COG1193	negative regulation of DNA recombination
A6J37_RS16655	COG2050	protein possibly involved in aromatic compounds catabolism
A6J37_RS16660	COG1169	isochorismate synthase
A6J37_RS16670	COG2095	MarC family integral membrane protein
A6J37_RS16685	COG2304	oxidoreductase activity
A6J37_RS16710	COG0714	Associated with various cellular activities
A6J37_RS16720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J37_RS16745	COG1309	transcriptional regulator
A6J37_RS16775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6J37_RS16815	COG1522	sequence-specific DNA binding
A6J37_RS16825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6J37_RS16835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6J37_RS16850	COG0252	asparaginase activity
A6J37_RS16895	COG1309	transcriptional regulator
A6J37_RS16910	COG2205	protein histidine kinase activity
A6J37_RS16910	COG0784	Response regulator, receiver
A6J37_RS16980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6J37_RS16985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6J37_RS16985	COG1648	precorrin-2 dehydrogenase activity
A6J37_RS16995	COG1045	serine acetyltransferase
A6J37_RS17005	COG0175	sulfate reduction
A6J37_RS17010	COG0175	sulfate reduction
A6J37_RS17015	COG1959	2 iron, 2 sulfur cluster binding
A6J37_RS17025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6J37_RS17035	COG0297	glycogen (starch) synthase activity
A6J37_RS17040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6J37_RS17045	COG0456	acetyltransferase
A6J37_RS17065	COG0010	Belongs to the arginase family
A6J37_RS17090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J37_RS17115	COG1137	ATPase activity
A6J37_RS17145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J37_RS17170	COG1086	Polysaccharide biosynthesis protein
A6J37_RS17180	COG0438	transferase activity, transferring glycosyl groups
A6J37_RS17185	COG0438	transferase activity, transferring glycosyl groups
A6J37_RS17220	COG0489	protein tyrosine kinase activity
A6J37_RS17220	COG3206	protein involved in exopolysaccharide biosynthesis
A6J37_RS17235	COG2137	regulation of response to DNA damage stimulus
A6J37_RS17250	COG0489	protein tyrosine kinase activity
A6J37_RS17250	COG3206	protein involved in exopolysaccharide biosynthesis
A6J37_RS17265	COG1132	(ABC) transporter
A6J37_RS17290	COG0438	transferase activity, transferring glycosyl groups
A6J37_RS17295	COG0438	transferase activity, transferring glycosyl groups
A6J37_RS17305	COG1442	glycosyl transferase family 8
A6J37_RS17305	COG1216	Glycosyl transferase, family 2
A6J37_RS17330	COG0463	Glycosyl transferase, family 2
A6J37_RS17350	COG1215	transferase activity, transferring glycosyl groups
A6J37_RS17355	COG1216	Glycosyl transferase, family 2
A6J37_RS17360	COG1216	Glycosyl transferase, family 2
A6J37_RS17365	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A6J37_RS17375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J37_RS17390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6J37_RS17430	COG1136	(ABC) transporter
A6J37_RS17435	COG1136	(ABC) transporter
A6J37_RS17435	COG0577	efflux transmembrane transporter activity
A6J37_RS17470	COG0702	epimerase
A6J37_RS17475	COG4771	TonB-dependent receptor
A6J37_RS17480	COG1629	transport
A6J37_RS17490	COG1418	mRNA catabolic process
A6J37_RS17500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J37_RS17510	COG0525	valine-tRNA ligase activity
A6J37_RS17520	COG3214	Protein conserved in bacteria
A6J37_RS17525	COG2326	polyphosphate kinase activity
A6J37_RS17550	COG0017	Asparaginyl-tRNA synthetase
A6J37_RS17570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6J37_RS17575	COG0228	four-way junction DNA binding
A6J37_RS17585	COG1132	(ABC) transporter
A6J37_RS17595	COG0101	tRNA pseudouridine synthase activity
A6J37_RS17610	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J37_RS17615	COG1733	regulation of RNA biosynthetic process
A6J37_RS17625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J37_RS17645	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J37_RS17650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6J37_RS17660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J37_RS17665	COG0564	pseudouridine synthase activity
A6J37_RS17670	COG0515	serine threonine protein kinase
A6J37_RS17675	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6J37_RS17680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6J37_RS17700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6J37_RS17705	COG1704	LemA family
A6J37_RS17725	COG0475	glutathione-regulated potassium exporter activity
A6J37_RS17725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6J37_RS17735	COG0339	signal peptide processing
A6J37_RS17780	COG4771	TonB-dependent receptor
A6J37_RS17810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6J37_RS17815	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6J37_RS17825	COG0028	Belongs to the TPP enzyme family
A6J37_RS17840	COG0509	glycine decarboxylation via glycine cleavage system
A6J37_RS17845	COG0632	four-way junction helicase activity
A6J37_RS17850	COG0280	phosphate acetyltransferase
A6J37_RS17850	COG0281	malic enzyme
A6J37_RS17900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6J37_RS17910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6J37_RS17915	COG1490	D-aminoacyl-tRNA deacylase activity
A6J37_RS17940	COG1408	metallophosphoesterase
A6J37_RS17980	COG1012	belongs to the aldehyde dehydrogenase family
A6J37_RS17980	COG2030	dehydratase
A6J37_RS17995	COG0183	Belongs to the thiolase family
A6J37_RS18005	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6J37_RS18010	COG1024	Enoyl-CoA hydratase
A6J37_RS18015	COG2151	metal-sulfur cluster biosynthetic enzyme
A6J37_RS18020	COG1073	alpha beta
A6J37_RS18030	COG3460	Phenylacetate-CoA oxygenase
A6J37_RS18035	COG3396	Phenylacetate-CoA oxygenase
A6J37_RS18045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J37_RS18050	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A6J37_RS18065	COG3842	ATPase activity
A6J37_RS18070	COG0542	response to heat
A6J37_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
A6J37_RS18110	COG3537	Alpha-1,2-mannosidase
A6J37_RS18115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6J37_RS18125	COG0756	dUTP diphosphatase activity
A6J37_RS18140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6J37_RS18155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J37_RS18160	COG1472	Belongs to the glycosyl hydrolase 3 family
A6J37_RS18165	COG0438	transferase activity, transferring glycosyl groups
A6J37_RS18170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6J37_RS18250	COG1858	cytochrome C peroxidase
A6J37_RS18300	COG0326	Molecular chaperone. Has ATPase activity
A6J37_RS18410	COG2223	nitrite transmembrane transporter activity
A6J37_RS18415	COG2207	Transcriptional regulator
A6J37_RS18450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J37_RS18495	COG3250	beta-galactosidase activity
A6J37_RS18525	COG0085	RNA polymerase activity
A6J37_RS18530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6J37_RS18570	COG0366	Alpha amylase catalytic
A6J37_RS18575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6J37_RS18640	COG0702	epimerase
A6J37_RS18645	COG1629	transport
A6J37_RS18650	COG1396	sequence-specific DNA binding
A6J37_RS18660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6J37_RS18670	COG4585	Histidine kinase
A6J37_RS18690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides