locus-tag	class	description
M876_RS00015	COG1028	Short-chain dehydrogenase reductase Sdr
M876_RS00020	COG1312	Catalyzes the dehydration of D-mannonate
M876_RS00025	COG1904	glucuronate isomerase
M876_RS00030	COG1609	Transcriptional regulator
M876_RS00055	COG1595	DNA-templated transcription, initiation
M876_RS00070	COG0254	rRNA binding
M876_RS00090	COG0300	oxidoreductase activity
M876_RS00100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M876_RS00120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M876_RS00125	COG0612	Peptidase, M16
M876_RS00175	COG1703	isobutyryl-CoA mutase activity
M876_RS00175	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M876_RS00175	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M876_RS00195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M876_RS00200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M876_RS00205	COG0052	Belongs to the universal ribosomal protein uS2 family
M876_RS00215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M876_RS00220	COG0517	IMP dehydrogenase activity
M876_RS00220	COG0516	GMP reductase activity
M876_RS00225	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M876_RS00235	COG0825	malonyl-CoA metabolic process
M876_RS00240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M876_RS00280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M876_RS00285	COG0439	Biotin carboxylase
M876_RS00290	COG0511	ligase activity, forming carbon-carbon bonds
M876_RS00295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M876_RS00305	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M876_RS00310	COG0307	riboflavin synthase, alpha
M876_RS00315	COG5000	phosphorelay sensor kinase activity
M876_RS00320	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M876_RS00325	COG2884	Cell division ATP-binding protein ftsE
M876_RS00330	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M876_RS00335	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M876_RS00350	COG2267	carboxylic ester hydrolase activity
M876_RS00370	COG0791	NLP P60 protein
M876_RS00380	COG1519	Transferase
M876_RS00380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M876_RS00390	COG0495	leucyl-tRNA aminoacylation
M876_RS00430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M876_RS00440	COG0745	RESPONSE REGULATOR receiver
M876_RS00445	COG2205	protein histidine kinase activity
M876_RS00450	COG4771	TonB-dependent receptor
M876_RS00465	COG1132	(ABC) transporter
M876_RS00470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M876_RS00485	COG0167	dihydroorotate dehydrogenase activity
M876_RS00490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M876_RS00495	COG2207	Transcriptional regulator
M876_RS00505	COG3655	Transcriptional regulator
M876_RS00535	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M876_RS00540	COG0658	competence protein
M876_RS00540	COG2333	competence protein COMEC
M876_RS00550	COG1053	succinate dehydrogenase
M876_RS00555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M876_RS00565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M876_RS00580	COG0237	dephospho-CoA kinase activity
M876_RS00585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M876_RS00595	COG2255	four-way junction helicase activity
M876_RS00605	COG0010	Belongs to the arginase family
M876_RS00610	COG1012	belongs to the aldehyde dehydrogenase family
M876_RS00615	COG1115	amino acid carrier protein
M876_RS00630	COG0571	ribonuclease III activity
M876_RS00635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M876_RS00640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M876_RS00645	COG0302	gtp cyclohydrolase
M876_RS00650	COG0215	cysteine-tRNA ligase activity
M876_RS00655	COG1640	4-alpha-glucanotransferase
M876_RS00675	COG1528	Iron-storage protein
M876_RS00680	COG2986	histidine ammonia-lyase
M876_RS00685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M876_RS00690	COG0861	Integral membrane protein TerC family
M876_RS00700	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M876_RS00710	COG0322	excinuclease ABC activity
M876_RS00725	COG1074	ATP-dependent DNA helicase activity
M876_RS00730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M876_RS00735	COG4974	Belongs to the 'phage' integrase family
M876_RS00765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M876_RS00785	COG3047	cAMP biosynthetic process
M876_RS00790	COG1733	regulation of RNA biosynthetic process
M876_RS00800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M876_RS00805	COG0081	regulation of translation
M876_RS00810	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M876_RS00815	COG0222	ribosome binding
M876_RS00820	COG1663	tetraacyldisaccharide 4'-kinase activity
M876_RS00825	COG1561	YicC-like family, N-terminal region
M876_RS00830	COG4106	trans-aconitate 2-methyltransferase activity
M876_RS00835	COG0194	GDP metabolic process
M876_RS00840	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M876_RS00885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M876_RS00895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M876_RS00905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M876_RS00920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M876_RS00940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M876_RS00950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M876_RS00965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M876_RS00970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M876_RS00975	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M876_RS00995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M876_RS01000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M876_RS01010	COG0552	protein localization to endoplasmic reticulum
M876_RS01015	COG2261	transglycosylase associated protein
M876_RS01020	COG0616	signal peptide processing
M876_RS01025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M876_RS01025	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M876_RS01040	COG0514	ATP-dependent DNA helicase (RecQ)
M876_RS01045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M876_RS01055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M876_RS01055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M876_RS01060	COG0544	peptidyl-prolyl cis-trans isomerase activity
M876_RS01065	COG1733	regulation of RNA biosynthetic process
M876_RS01140	COG2176	DNA-directed DNA polymerase activity
M876_RS01145	COG1183	phosphatidylcholine synthase activity
M876_RS01165	COG0022	dehydrogenase e1 component
M876_RS01165	COG0508	dehydrogenase complex catalyzes the overall conversion of
M876_RS01170	COG3158	transport of potassium into the cell
M876_RS01185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M876_RS01205	COG1678	Uncharacterized ACR, COG1678
M876_RS01210	COG0259	pyridoxamine-phosphate oxidase activity
M876_RS01220	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M876_RS01230	COG1047	Peptidyl-prolyl cis-trans
M876_RS01235	COG4628	conserved protein (DUF2132)
M876_RS01250	COG0339	signal peptide processing
M876_RS01295	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M876_RS01300	COG1881	PFAM PEBP family protein
M876_RS01325	COG2267	carboxylic ester hydrolase activity
M876_RS01355	COG0494	nUDIX hydrolase
M876_RS01400	COG0459	protein refolding
M876_RS01405	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M876_RS01435	COG4221	oxidoreductase activity
M876_RS01455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M876_RS01460	COG0504	CTP synthase activity
M876_RS01465	COG0706	membrane insertase activity
M876_RS01470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M876_RS01475	COG4771	TonB-dependent receptor
M876_RS01485	COG1629	transport
M876_RS01495	COG0018	arginyl-trna synthetase
M876_RS01505	COG0308	aminopeptidase N
M876_RS01515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M876_RS01540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M876_RS01555	COG3321	synthase
M876_RS01555	COG0604	alcohol dehydrogenase
M876_RS01570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M876_RS01610	COG2801	Transposase and inactivated derivatives
M876_RS01675	COG0488	(ABC) transporter
M876_RS01685	COG2363	Small membrane protein
M876_RS01695	COG0045	succinate-CoA ligase (ADP-forming) activity
M876_RS01700	COG3264	Mechanosensitive ion channel
M876_RS01700	COG1196	nuclear chromosome segregation
M876_RS01710	COG4206	TonB-dependent receptor
M876_RS01715	COG0673	inositol 2-dehydrogenase activity
M876_RS01725	COG0813	purine-nucleoside phosphorylase activity
M876_RS01730	COG0488	(ABC) transporter
M876_RS01735	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
M876_RS01750	COG0336	Belongs to the RNA methyltransferase TrmD family
M876_RS01760	COG1522	sequence-specific DNA binding
M876_RS01775	COG0113	porphobilinogen synthase activity
M876_RS01780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M876_RS01790	COG0436	Aminotransferase
M876_RS01800	COG1704	LemA family
M876_RS01810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M876_RS01830	COG1160	GTP binding
M876_RS01840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M876_RS01845	COG1040	competence protein
M876_RS01850	COG1396	sequence-specific DNA binding
M876_RS01855	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M876_RS01860	COG2224	Isocitrate lyase
M876_RS01875	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M876_RS01880	COG0720	synthase
M876_RS01885	COG4771	TonB-dependent receptor
M876_RS01895	COG0205	6-phosphofructokinase activity
M876_RS01900	COG1629	transport
M876_RS01910	COG3119	arylsulfatase activity
M876_RS01915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M876_RS01940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M876_RS01945	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M876_RS01950	COG1301	dicarboxylic acid transport
M876_RS01955	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
M876_RS01985	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M876_RS01995	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M876_RS02000	COG1794	racemase activity, acting on amino acids and derivatives
M876_RS02005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M876_RS02020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M876_RS02040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M876_RS02065	COG0708	Exodeoxyribonuclease III
M876_RS02095	COG0489	protein tyrosine kinase activity
M876_RS02100	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M876_RS02110	COG0248	Ppx GppA phosphatase
M876_RS02115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M876_RS02120	COG0443	Heat shock 70 kDa protein
M876_RS02175	COG0284	orotidine-5'-phosphate decarboxylase activity
M876_RS02175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M876_RS02180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M876_RS02195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M876_RS02200	COG0242	peptide deformylase activity
M876_RS02210	COG3956	TIGRFAM MazG family protein
M876_RS02215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M876_RS02220	COG2936	dipeptidyl-peptidase activity
M876_RS02260	COG1007	ATP synthesis coupled electron transport
M876_RS02265	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M876_RS02270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M876_RS02275	COG0713	ATP synthesis coupled electron transport
M876_RS02280	COG0839	Belongs to the complex I subunit 6 family
M876_RS02285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M876_RS02290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M876_RS02295	COG1034	ATP synthesis coupled electron transport
M876_RS02305	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M876_RS02310	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M876_RS02315	COG0649	NAD binding
M876_RS02320	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M876_RS02325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M876_RS02330	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M876_RS02355	COG0356	it plays a direct role in the translocation of protons across the membrane
M876_RS02360	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M876_RS02365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M876_RS02370	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M876_RS02375	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M876_RS02380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M876_RS02390	COG1253	flavin adenine dinucleotide binding
M876_RS02395	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M876_RS02410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M876_RS02435	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M876_RS02440	COG0528	UMP kinase activity
M876_RS02445	COG0233	cytoplasmic translational termination
M876_RS02450	COG3119	arylsulfatase activity
M876_RS02475	COG4771	TonB-dependent receptor
M876_RS02490	COG1063	alcohol dehydrogenase
M876_RS02565	COG3621	Patatin-like phospholipase
M876_RS02570	COG1876	peptidase activity
M876_RS02600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M876_RS02600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M876_RS02625	COG0745	RESPONSE REGULATOR receiver
M876_RS02625	COG2972	Histidine kinase
M876_RS02630	COG3279	Response regulator of the LytR AlgR family
M876_RS02640	COG1250	3-hydroxyacyl-CoA dehydrogenase
M876_RS02640	COG1024	Enoyl-CoA hydratase
M876_RS02645	COG4716	Myosin-crossreactive antigen
M876_RS02665	COG0471	metal ion transport
M876_RS02675	COG1053	succinate dehydrogenase
M876_RS02680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M876_RS02705	COG1028	Short-chain dehydrogenase reductase Sdr
M876_RS02710	COG0038	chloride channel
M876_RS02740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M876_RS02745	COG2207	Transcriptional regulator
M876_RS02760	COG1309	transcriptional regulator
M876_RS02765	COG0183	Belongs to the thiolase family
M876_RS02780	COG0183	Belongs to the thiolase family
M876_RS02790	COG0494	nUDIX hydrolase
M876_RS02795	COG0561	phosphatase activity
M876_RS02815	COG1131	(ABC) transporter
M876_RS02820	COG3655	Transcriptional regulator
M876_RS02830	COG1960	acyl-CoA dehydrogenase activity
M876_RS02845	COG3541	Predicted nucleotidyltransferase
M876_RS02895	COG1858	cytochrome C peroxidase
M876_RS02930	COG0038	chloride channel
M876_RS02965	COG0659	secondary active sulfate transmembrane transporter activity
M876_RS02995	COG1733	regulation of RNA biosynthetic process
M876_RS03000	COG2814	Major facilitator Superfamily
M876_RS03010	COG2807	transmembrane transport
M876_RS03065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M876_RS03075	COG0156	8-amino-7-oxononanoate synthase activity
M876_RS03080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M876_RS03085	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M876_RS03090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M876_RS03095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M876_RS03100	COG1959	2 iron, 2 sulfur cluster binding
M876_RS03115	COG4654	Cytochrome c, class I
M876_RS03120	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
M876_RS03155	COG1538	Outer membrane efflux protein
M876_RS03175	COG1629	transport
M876_RS03175	COG4206	TonB-dependent receptor
M876_RS03185	COG2610	gluconate transmembrane transporter activity
M876_RS03200	COG0800	Aldolase
M876_RS03215	COG1349	DNA-binding transcription factor activity
M876_RS03250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M876_RS03290	COG2706	6-phosphogluconolactonase activity
M876_RS03375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M876_RS03380	COG0006	proline dipeptidase activity
M876_RS03385	COG1012	belongs to the aldehyde dehydrogenase family
M876_RS03395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M876_RS03400	COG3118	belongs to the thioredoxin family
M876_RS03415	COG3876	Protein conserved in bacteria
M876_RS03435	COG4145	pantothenate transmembrane transporter activity
M876_RS03445	COG0402	S-adenosylhomocysteine deaminase activity
M876_RS03455	COG0666	response to abiotic stimulus
M876_RS03460	COG0402	S-adenosylhomocysteine deaminase activity
M876_RS03465	COG0456	acetyltransferase
M876_RS03480	COG0367	asparagine synthase
M876_RS03490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M876_RS03490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M876_RS03495	COG2824	Alkylphosphonate utilization operon protein PhnA
M876_RS03515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M876_RS03525	COG0492	ferredoxin-NADP+ reductase activity
M876_RS03550	COG2195	Cleaves the N-terminal amino acid of tripeptides
M876_RS03565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M876_RS03590	COG1674	ftsk spoiiie
M876_RS03595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M876_RS03595	COG1333	cytochrome c biogenesis protein
M876_RS03630	COG1011	Hydrolase
M876_RS03650	COG0492	ferredoxin-NADP+ reductase activity
M876_RS03690	COG0351	phosphomethylpyrimidine kinase
M876_RS03695	COG0352	thiamine-phosphate diphosphorylase activity
M876_RS03700	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M876_RS03710	COG3279	Response regulator of the LytR AlgR family
M876_RS03715	COG0475	glutathione-regulated potassium exporter activity
M876_RS03735	COG1917	Cupin 2, conserved barrel domain protein
M876_RS03735	COG4977	sequence-specific DNA binding
M876_RS03750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M876_RS03760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M876_RS03790	COG3023	N-Acetylmuramoyl-L-alanine amidase
M876_RS03795	COG1027	Aspartate ammonia-lyase
M876_RS03800	COG0612	Peptidase, M16
M876_RS03805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M876_RS03810	COG1472	Belongs to the glycosyl hydrolase 3 family
M876_RS03815	COG4717	serine-type aminopeptidase activity
M876_RS03840	COG2205	protein histidine kinase activity
M876_RS03850	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
M876_RS03860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M876_RS03870	COG2204	response regulator
M876_RS03875	COG2217	Heavy metal translocating P-type atpase
M876_RS03880	COG3279	Response regulator of the LytR AlgR family
M876_RS03885	COG2972	Histidine kinase
M876_RS03910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M876_RS03920	COG2272	Belongs to the type-B carboxylesterase lipase family
M876_RS03930	COG0300	oxidoreductase activity
M876_RS03935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M876_RS03945	COG1131	(ABC) transporter
M876_RS03950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M876_RS03960	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M876_RS03970	COG0586	Pfam SNARE associated Golgi protein
M876_RS03975	COG0358	DNA primase activity
M876_RS04005	COG0697	spore germination
M876_RS04010	COG1522	sequence-specific DNA binding
M876_RS04015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M876_RS04045	COG0149	triose-phosphate isomerase activity
M876_RS04050	COG2264	protein methyltransferase activity
M876_RS04060	COG0739	heme binding
M876_RS04065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M876_RS04070	COG0579	oxidoreductase
M876_RS04080	COG2271	Major facilitator Superfamily
M876_RS04085	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M876_RS04090	COG1028	Short-chain dehydrogenase reductase Sdr
M876_RS04105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M876_RS04110	COG1085	galactose-1-phosphate uridylyltransferase
M876_RS04115	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M876_RS04120	COG2017	converts alpha-aldose to the beta-anomer
M876_RS04150	COG1970	mechanosensitive ion channel activity
M876_RS04160	COG1970	mechanosensitive ion channel activity
M876_RS04195	COG2801	Transposase and inactivated derivatives
M876_RS04265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M876_RS04285	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M876_RS04295	COG1566	PFAM secretion protein HlyD family protein
M876_RS04310	COG1446	asparaginase
M876_RS04325	COG2755	lipolytic protein G-D-S-L family
M876_RS04345	COG1506	peptidase
M876_RS04345	COG0823	Involved in the tonB-independent uptake of proteins
M876_RS04355	COG3104	oligopeptide transport
M876_RS04360	COG3104	oligopeptide transport
M876_RS04365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M876_RS04370	COG4771	TonB-dependent receptor
M876_RS04375	COG3361	conserved protein (COG2071)
M876_RS04380	COG0617	tRNA 3'-terminal CCA addition
M876_RS04380	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M876_RS04380	COG0517	IMP dehydrogenase activity
M876_RS04385	COG0009	L-threonylcarbamoyladenylate synthase
M876_RS04390	COG0626	cystathionine gamma-synthase activity
M876_RS04410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M876_RS04420	COG2732	(Barnase) inhibitor
M876_RS04435	COG0745	RESPONSE REGULATOR receiver
M876_RS04440	COG5002	protein histidine kinase activity
M876_RS04470	COG0596	Alpha beta hydrolase
M876_RS04485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M876_RS04500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M876_RS04530	COG1058	Belongs to the CinA family
M876_RS04530	COG1546	Belongs to the CinA family
M876_RS04540	COG3590	peptidase
M876_RS04555	COG3590	peptidase
M876_RS04565	COG2234	aminopeptidase activity
M876_RS04590	COG3185	4-Hydroxyphenylpyruvate dioxygenase
M876_RS04595	COG0427	acetyl-CoA hydrolase
M876_RS04605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M876_RS04620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M876_RS04630	COG2268	Band 7 protein
M876_RS04645	COG1530	ribonuclease E activity
M876_RS04650	COG0776	regulation of translation
M876_RS04655	COG1194	a g-specific adenine glycosylase
M876_RS04670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M876_RS04720	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M876_RS04725	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M876_RS04730	COG0612	Peptidase, M16
M876_RS04735	COG0612	Peptidase, M16
M876_RS04745	COG2378	regulation of single-species biofilm formation
M876_RS04755	COG3781	membrane
M876_RS04760	COG2814	Major facilitator Superfamily
M876_RS04780	COG2353	YceI-like domain
M876_RS04785	COG3384	dioxygenase
M876_RS04790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M876_RS04815	COG2169	Transcriptional regulator
M876_RS04815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M876_RS04830	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M876_RS04840	COG0730	response to heat
M876_RS04870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M876_RS04870	COG0140	phosphoribosyl-ATP diphosphatase activity
M876_RS04875	COG0107	imidazoleglycerol-phosphate synthase activity
M876_RS04885	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M876_RS04900	COG0131	Imidazoleglycerol-phosphate dehydratase
M876_RS04910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M876_RS04915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M876_RS04920	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M876_RS04925	COG0477	Major facilitator Superfamily
M876_RS04930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M876_RS04935	COG1741	Belongs to the pirin family
M876_RS04970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M876_RS04985	COG1702	phosphate starvation-inducible protein PhoH
M876_RS05005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M876_RS05020	COG0592	DNA-directed DNA polymerase activity
M876_RS05040	COG1250	3-hydroxyacyl-CoA dehydrogenase
M876_RS05060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M876_RS05075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M876_RS05085	COG4574	serine-type endopeptidase inhibitor activity
M876_RS05095	COG0405	Gamma-glutamyltransferase
M876_RS05100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M876_RS05115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M876_RS05125	COG2226	methyltransferase
M876_RS05140	COG1418	mRNA catabolic process
M876_RS05175	COG1335	isochorismatase
M876_RS05195	COG4935	Belongs to the peptidase S8 family
M876_RS05195	COG2234	aminopeptidase activity
M876_RS05210	COG3345	alpha-galactosidase
M876_RS05230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M876_RS05230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M876_RS05235	COG0463	Glycosyl transferase, family 2
M876_RS05235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M876_RS05260	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M876_RS05265	COG4677	pectinesterase activity
M876_RS05270	COG1464	Belongs to the NlpA lipoprotein family
M876_RS05275	COG2011	ABC-type metal ion transport system permease component
M876_RS05280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M876_RS05290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M876_RS05310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M876_RS05315	COG0563	adenylate kinase activity
M876_RS05320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M876_RS05325	COG0513	Belongs to the DEAD box helicase family
M876_RS05330	COG0084	hydrolase, TatD family'
M876_RS05345	COG0306	phosphate transporter
M876_RS05360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M876_RS05365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M876_RS05375	COG1192	Involved in chromosome partitioning
M876_RS05380	COG1475	DNA binding
M876_RS05390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M876_RS05395	COG0681	Belongs to the peptidase S26 family
M876_RS05415	COG2885	chlorophyll binding
M876_RS05420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M876_RS05430	COG1104	cysteine desulfurase activity
M876_RS05460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M876_RS05465	COG2197	response regulator
M876_RS05535	COG0542	response to heat
M876_RS05605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M876_RS05625	COG0596	Alpha beta hydrolase
M876_RS05650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M876_RS05655	COG0697	spore germination
M876_RS05660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M876_RS05670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M876_RS05680	COG3708	Transcriptional regulator
M876_RS05715	COG1064	alcohol dehydrogenase
M876_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
M876_RS05745	COG1999	signal sequence binding
M876_RS05750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M876_RS05755	COG1234	tRNA 3'-trailer cleavage
M876_RS05760	COG2814	Major facilitator Superfamily
M876_RS05770	COG2194	sulfuric ester hydrolase activity
M876_RS05790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M876_RS05790	COG2207	Transcriptional regulator
M876_RS05815	COG2076	Multidrug Resistance protein
M876_RS05820	COG1785	Belongs to the alkaline phosphatase family
M876_RS05830	COG1733	regulation of RNA biosynthetic process
M876_RS05835	COG1733	regulation of RNA biosynthetic process
M876_RS05845	COG0778	Nitroreductase
M876_RS05855	COG2207	Transcriptional regulator
M876_RS05875	COG3275	phosphorelay sensor kinase activity
M876_RS05880	COG3279	Response regulator of the LytR AlgR family
M876_RS05900	COG0431	NADPH-dependent FMN reductase
M876_RS05940	COG1028	Short-chain dehydrogenase reductase Sdr
M876_RS05950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M876_RS06005	COG2197	response regulator
M876_RS06010	COG0415	Belongs to the DNA photolyase family
M876_RS06035	COG0300	oxidoreductase activity
M876_RS06040	COG0519	Catalyzes the synthesis of GMP from XMP
M876_RS06110	COG0024	Methionine aminopeptidase
M876_RS06115	COG0242	peptide deformylase activity
M876_RS06125	COG0656	L-ascorbic acid biosynthetic process
M876_RS06130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M876_RS06150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M876_RS06220	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M876_RS06230	COG3781	membrane
M876_RS06270	COG4771	TonB-dependent receptor
M876_RS06345	COG0523	cobalamin synthesis protein
M876_RS06360	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M876_RS06380	COG0662	Cupin 2, conserved barrel domain protein
M876_RS06380	COG2207	Transcriptional regulator
M876_RS06385	COG2375	cellular response to nickel ion
M876_RS06390	COG0534	Mate efflux family protein
M876_RS06405	COG1611	Belongs to the LOG family
M876_RS06425	COG0456	acetyltransferase
M876_RS06430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M876_RS06450	COG1309	transcriptional regulator
M876_RS06485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M876_RS06495	COG1764	response to oxidative stress
M876_RS06500	COG1846	Transcriptional regulator
M876_RS06515	COG3781	membrane
M876_RS06520	COG0025	NhaP-type Na H and K H
M876_RS06530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M876_RS06560	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M876_RS06570	COG1289	transmembrane transporter activity
M876_RS06580	COG2249	NAD(P)H dehydrogenase (quinone) activity
M876_RS06585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M876_RS06600	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M876_RS06620	COG0598	Magnesium transport protein CorA
M876_RS06625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M876_RS06630	COG3537	Alpha-1,2-mannosidase
M876_RS06635	COG0583	DNA-binding transcription factor activity
M876_RS06640	COG2814	Major facilitator Superfamily
M876_RS06645	COG1902	pentaerythritol trinitrate reductase activity
M876_RS06650	COG0667	Aldo Keto reductase
M876_RS06680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M876_RS06685	COG0297	glycogen (starch) synthase activity
M876_RS06690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M876_RS06705	COG0508	dehydrogenase complex catalyzes the overall conversion of
M876_RS06710	COG2967	ApaG domain
M876_RS06715	COG0697	spore germination
M876_RS06750	COG2133	pyrroloquinoline quinone binding
M876_RS06755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M876_RS06775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M876_RS06780	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M876_RS06785	COG1629	transport
M876_RS06785	COG4206	TonB-dependent receptor
M876_RS06790	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M876_RS06800	COG3408	Glycogen debranching enzyme
M876_RS06800	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
M876_RS06805	COG1082	Xylose isomerase domain protein TIM barrel
M876_RS06815	COG1741	Belongs to the pirin family
M876_RS06825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M876_RS06830	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M876_RS06845	COG0151	Belongs to the GarS family
M876_RS06850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M876_RS06850	COG0519	Catalyzes the synthesis of GMP from XMP
M876_RS06855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M876_RS06860	COG0513	Belongs to the DEAD box helicase family
M876_RS06880	COG1979	alcohol dehydrogenase
M876_RS06900	COG3153	acetyltransferase
M876_RS06905	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M876_RS06925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M876_RS06930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M876_RS06950	COG2003	Belongs to the UPF0758 family
M876_RS06955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M876_RS06960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M876_RS06965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M876_RS06975	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M876_RS06975	COG1605	Chorismate mutase
M876_RS06985	COG1131	(ABC) transporter
M876_RS07005	COG1187	pseudouridine synthase activity
M876_RS07020	COG1335	isochorismatase
M876_RS07030	COG3118	belongs to the thioredoxin family
M876_RS07040	COG0242	peptide deformylase activity
M876_RS07060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M876_RS07065	COG1363	Peptidase, m42
M876_RS07085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M876_RS07085	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M876_RS07090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M876_RS07105	COG2890	protein-(glutamine-N5) methyltransferase activity
M876_RS07110	COG3022	response to hydroperoxide
M876_RS07115	COG0009	L-threonylcarbamoyladenylate synthase
M876_RS07140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M876_RS07145	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M876_RS07170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M876_RS07175	COG1970	mechanosensitive ion channel activity
M876_RS07180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M876_RS07190	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M876_RS07195	COG0077	Prephenate dehydratase
M876_RS07215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M876_RS07225	COG0505	Belongs to the CarA family
M876_RS07255	COG0583	DNA-binding transcription factor activity
M876_RS07260	COG2855	membrane
M876_RS07335	COG0745	RESPONSE REGULATOR receiver
M876_RS07355	COG1012	belongs to the aldehyde dehydrogenase family
M876_RS07390	COG0791	NLP P60 protein
M876_RS07395	COG2171	N-acyltransferase activity
M876_RS07405	COG0463	Glycosyl transferase, family 2
M876_RS07425	COG0159	tryptophan synthase activity
M876_RS07430	COG0133	tryptophan synthase activity
M876_RS07440	COG0135	phosphoribosylanthranilate isomerase activity
M876_RS07445	COG0134	indole-3-glycerol-phosphate synthase activity
M876_RS07450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M876_RS07455	COG0512	Glutamine amidotransferase of anthranilate synthase
M876_RS07465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M876_RS07475	COG0531	amino acid
M876_RS07555	COG0314	molybdopterin synthase activity
M876_RS07560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M876_RS07580	COG3781	membrane
M876_RS07595	COG0746	molybdenum cofactor guanylyltransferase activity
M876_RS07595	COG0315	cyclic pyranopterin monophosphate synthase activity
M876_RS07610	COG0303	'Molybdopterin
M876_RS07635	COG0519	Catalyzes the synthesis of GMP from XMP
M876_RS07675	COG1217	gtp-binding protein TYPA
M876_RS07685	COG0531	amino acid
M876_RS07700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M876_RS07715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M876_RS07730	COG0671	phosphoesterase, PA-phosphatase related
M876_RS07750	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M876_RS07755	COG1295	ribonuclease BN
M876_RS07765	COG0295	cytidine deaminase activity
M876_RS07770	COG4771	TonB-dependent receptor
M876_RS07815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M876_RS07820	COG3938	Belongs to the proline racemase family
M876_RS07830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M876_RS07835	COG2207	Transcriptional regulator
M876_RS07840	COG0006	proline dipeptidase activity
M876_RS07845	COG1506	peptidase
M876_RS07845	COG0823	Involved in the tonB-independent uptake of proteins
M876_RS07845	COG4946	Tricorn protease homolog
M876_RS07860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M876_RS07865	COG3340	Belongs to the peptidase S51 family
M876_RS07875	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M876_RS07880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M876_RS07885	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M876_RS07920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M876_RS07925	COG1234	tRNA 3'-trailer cleavage
M876_RS07945	COG0670	Belongs to the BI1 family
M876_RS07960	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
M876_RS07970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M876_RS07975	COG2177	Part of the ABC transporter FtsEX involved in
M876_RS07985	COG1968	undecaprenyl-diphosphatase activity
M876_RS07995	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M876_RS08035	COG1960	acyl-CoA dehydrogenase activity
M876_RS08040	COG0183	Belongs to the thiolase family
M876_RS08050	COG1024	Enoyl-CoA hydratase
M876_RS08050	COG1250	3-hydroxyacyl-CoA dehydrogenase
M876_RS08060	COG1120	ATPase activity
M876_RS08070	COG3118	belongs to the thioredoxin family
M876_RS08075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M876_RS08075	COG1017	nitric oxide dioxygenase activity
M876_RS08080	COG2949	membrane
M876_RS08095	COG0572	uridine kinase
M876_RS08105	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M876_RS08105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M876_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
M876_RS08135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M876_RS08145	COG2211	Major facilitator Superfamily
M876_RS08150	COG0460	homoserine dehydrogenase
M876_RS08150	COG0527	aspartate kinase activity
M876_RS08155	COG0083	homoserine kinase activity
M876_RS08160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M876_RS08170	COG0183	Belongs to the thiolase family
M876_RS08175	COG2270	Major facilitator Superfamily
M876_RS08180	COG0105	UTP biosynthetic process
M876_RS08190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M876_RS08195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M876_RS08225	COG1803	Methylglyoxal synthase
M876_RS08245	COG0450	alkyl hydroperoxide reductase
M876_RS08250	COG0612	Peptidase, M16
M876_RS08255	COG0436	Aminotransferase
M876_RS08260	COG0357	Ribosomal RNA small subunit methyltransferase G
M876_RS08280	COG0012	GTP binding
M876_RS08290	COG0436	Aminotransferase
M876_RS08315	COG1280	lysine exporter protein (LysE YggA)
M876_RS08320	COG3012	SEC-C Motif Domain Protein
M876_RS08340	COG1960	acyl-CoA dehydrogenase activity
M876_RS08350	COG4977	sequence-specific DNA binding
M876_RS08355	COG2211	Major facilitator Superfamily
M876_RS08360	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
M876_RS08365	COG0076	glutamate decarboxylase activity
M876_RS08370	COG3486	L-lysine 6-monooxygenase (NADPH) activity
M876_RS08390	COG1131	(ABC) transporter
M876_RS08410	COG0346	lactoylglutathione lyase activity
M876_RS08415	COG0431	NADPH-dependent FMN reductase
M876_RS08465	COG3275	phosphorelay sensor kinase activity
M876_RS08470	COG3279	Response regulator of the LytR AlgR family
M876_RS08490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M876_RS08500	COG1538	Outer membrane efflux protein
M876_RS08510	COG3279	Response regulator of the LytR AlgR family
M876_RS08520	COG0187	DNA topoisomerase II activity
M876_RS08525	COG1271	oxidase subunit
M876_RS08565	COG2814	Major facilitator Superfamily
M876_RS08575	COG0667	Aldo Keto reductase
M876_RS08585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M876_RS08595	COG4654	Cytochrome c, class I
M876_RS08615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M876_RS08640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M876_RS08655	COG1113	amino acid transport
M876_RS08675	COG0488	(ABC) transporter
M876_RS08685	COG1506	peptidase
M876_RS08695	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M876_RS08705	COG2226	methyltransferase
M876_RS08725	COG0456	acetyltransferase
M876_RS08730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M876_RS08740	COG0813	purine-nucleoside phosphorylase activity
M876_RS08755	COG0519	Catalyzes the synthesis of GMP from XMP
M876_RS08775	COG1321	iron dependent repressor
M876_RS08800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M876_RS08805	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M876_RS08810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M876_RS08830	COG1752	Esterase of the alpha-beta hydrolase superfamily
M876_RS08835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M876_RS08845	COG0022	dehydrogenase e1 component
M876_RS08860	COG2197	response regulator
M876_RS08880	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M876_RS08885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M876_RS08905	COG0156	8-amino-7-oxononanoate synthase activity
M876_RS08910	COG2027	D-alanyl-D-alanine carboxypeptidase
M876_RS08915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M876_RS08925	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M876_RS08945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M876_RS08945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M876_RS08965	COG1566	PFAM secretion protein HlyD family protein
M876_RS08980	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M876_RS08995	COG1960	acyl-CoA dehydrogenase activity
M876_RS09000	COG1022	Amp-dependent synthetase and ligase
M876_RS09010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M876_RS09020	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M876_RS09040	COG2197	response regulator
M876_RS09055	COG0534	Mate efflux family protein
M876_RS09070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M876_RS09070	COG3153	acetyltransferase
M876_RS09095	COG0745	RESPONSE REGULATOR receiver
M876_RS09100	COG0321	lipoyl(octanoyl) transferase activity
M876_RS09105	COG0508	dehydrogenase complex catalyzes the overall conversion of
M876_RS09140	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M876_RS09160	COG0360	Binds together with S18 to 16S ribosomal RNA
M876_RS09165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M876_RS09170	COG0359	binds to the 23S rRNA
M876_RS09185	COG0069	glutamate synthase activity
M876_RS09190	COG1607	acyl-coa hydrolase
M876_RS09205	COG2217	Heavy metal translocating P-type atpase
M876_RS09220	COG0671	phosphoesterase, PA-phosphatase related
M876_RS09225	COG0584	glycerophosphoryl diester phosphodiesterase
M876_RS09235	COG2027	D-alanyl-D-alanine carboxypeptidase
M876_RS09240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M876_RS09245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M876_RS09255	COG0823	Involved in the tonB-independent uptake of proteins
M876_RS09255	COG1506	peptidase
M876_RS09265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M876_RS09270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M876_RS09290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M876_RS09300	COG3511	phospholipase C
M876_RS09310	COG0702	epimerase
M876_RS09315	COG1629	transport
M876_RS09320	COG1349	DNA-binding transcription factor activity
M876_RS09330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M876_RS09335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M876_RS09350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M876_RS09355	COG1902	pentaerythritol trinitrate reductase activity
M876_RS09360	COG1733	regulation of RNA biosynthetic process
M876_RS09385	COG0124	histidyl-tRNA synthetase
M876_RS09390	COG0629	single-stranded DNA binding
M876_RS09400	COG0745	RESPONSE REGULATOR receiver
M876_RS09420	COG0028	Belongs to the TPP enzyme family
M876_RS09490	COG2207	Transcriptional regulator
M876_RS09510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M876_RS09520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M876_RS09545	COG0335	large ribosomal subunit rRNA binding
M876_RS09550	COG0494	nUDIX hydrolase
M876_RS09555	COG2207	Transcriptional regulator
M876_RS09560	COG2814	Major facilitator Superfamily
M876_RS09570	COG0477	Major facilitator Superfamily
M876_RS09575	COG0004	ammonium transporteR
M876_RS09590	COG0539	negative regulation of cytoplasmic translation
M876_RS09590	COG2183	response to ionizing radiation
M876_RS09595	COG0513	Belongs to the DEAD box helicase family
M876_RS09620	COG0793	Belongs to the peptidase S41A family
M876_RS09620	COG3409	Peptidoglycan-binding domain 1 protein
M876_RS09645	COG1119	ATPase activity
M876_RS09650	COG1960	acyl-CoA dehydrogenase activity
M876_RS09675	COG0066	3-isopropylmalate dehydratase activity
M876_RS09680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M876_RS09685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M876_RS09695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M876_RS09700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M876_RS09705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M876_RS09710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M876_RS09715	COG0673	inositol 2-dehydrogenase activity
M876_RS09735	COG3275	phosphorelay sensor kinase activity
M876_RS09740	COG3279	Response regulator of the LytR AlgR family
M876_RS09750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M876_RS09765	COG0069	glutamate synthase activity
M876_RS09765	COG0067	glutamate synthase
M876_RS09765	COG0070	glutamate synthase
M876_RS09770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M876_RS09770	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M876_RS09785	COG0724	RNA recognition motif
M876_RS09795	COG0514	ATP-dependent DNA helicase (RecQ)
M876_RS09800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M876_RS09800	COG0517	IMP dehydrogenase activity
M876_RS09805	COG0805	protein transport
M876_RS09820	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M876_RS09830	COG2076	Multidrug Resistance protein
M876_RS09850	COG0156	8-amino-7-oxononanoate synthase activity
M876_RS09870	COG1696	Membrane protein involved in D-alanine export
M876_RS09890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M876_RS09895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M876_RS09900	COG0196	riboflavin kinase activity
M876_RS09910	COG3250	beta-galactosidase activity
M876_RS09920	COG0386	Belongs to the glutathione peroxidase family
M876_RS09930	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M876_RS09940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M876_RS09960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M876_RS09970	COG1575	Belongs to the MenA family. Type 1 subfamily
M876_RS09985	COG2706	6-phosphogluconolactonase activity
M876_RS09995	COG0531	amino acid
M876_RS10010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M876_RS10015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M876_RS10095	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M876_RS10100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M876_RS10120	COG1428	Deoxynucleoside kinase
M876_RS10125	COG1733	regulation of RNA biosynthetic process
M876_RS10140	COG2837	iron assimilation
M876_RS10180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M876_RS10195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M876_RS10205	COG1629	transport
M876_RS10225	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M876_RS10230	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M876_RS10235	COG0363	glucosamine-6-phosphate deaminase activity
M876_RS10275	COG2207	Transcriptional regulator
M876_RS10295	COG2910	NAD(P)H-binding
M876_RS10315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M876_RS10370	COG0022	dehydrogenase e1 component
M876_RS10380	COG1473	amidohydrolase
M876_RS10390	COG4221	oxidoreductase activity
M876_RS10400	COG0463	Glycosyl transferase, family 2
M876_RS10400	COG1216	Glycosyl transferase, family 2
M876_RS10405	COG0116	Belongs to the methyltransferase superfamily
M876_RS10435	COG0442	prolyl-tRNA aminoacylation
M876_RS10455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M876_RS10460	COG0484	heat shock protein binding
M876_RS10470	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M876_RS10475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M876_RS10525	COG2723	6-phospho-beta-galactosidase activity
M876_RS10540	COG2217	Heavy metal translocating P-type atpase
M876_RS10560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M876_RS10580	COG2814	Major facilitator Superfamily
M876_RS10590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M876_RS10590	COG2755	lipolytic protein G-D-S-L family
M876_RS10595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M876_RS10600	COG3548	integral membrane protein
M876_RS10615	COG1595	DNA-templated transcription, initiation
M876_RS10620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M876_RS10625	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M876_RS10665	COG0730	response to heat
M876_RS10670	COG2186	Transcriptional regulator
M876_RS10675	COG1764	response to oxidative stress
M876_RS10680	COG0798	PFAM Bile acid sodium symporter
M876_RS10740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M876_RS10765	COG1629	transport
M876_RS10785	COG0745	RESPONSE REGULATOR receiver
M876_RS10790	COG5002	protein histidine kinase activity
M876_RS10795	COG0456	acetyltransferase
M876_RS10800	COG5006	permease, DMT superfamily
M876_RS10805	COG0456	acetyltransferase
M876_RS10815	COG3118	belongs to the thioredoxin family
M876_RS10825	COG4753	response regulator
M876_RS10825	COG2207	Transcriptional regulator
M876_RS10845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M876_RS10850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M876_RS10870	COG1285	pathogenesis
M876_RS10900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M876_RS10905	COG2022	thiamine diphosphate biosynthetic process
M876_RS10910	COG0352	thiamine-phosphate diphosphorylase activity
M876_RS10925	COG2104	thiamine diphosphate biosynthetic process
M876_RS10930	COG1446	asparaginase
M876_RS10935	COG4152	abc transporter atp-binding protein
M876_RS10950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M876_RS10955	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M876_RS10960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M876_RS10965	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M876_RS10970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M876_RS10970	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M876_RS10975	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M876_RS10980	COG1078	dGTPase activity
M876_RS11000	COG0686	Belongs to the AlaDH PNT family
M876_RS11010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M876_RS11015	COG0287	Prephenate dehydrogenase
M876_RS11030	COG1760	l-serine dehydratase
M876_RS11050	COG0837	glucose binding
M876_RS11070	COG1185	polyribonucleotide nucleotidyltransferase activity
M876_RS11080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M876_RS11090	COG2239	Acts as a magnesium transporter
M876_RS11095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M876_RS11100	COG3813	Protein conserved in bacteria
M876_RS11115	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M876_RS11115	COG0321	lipoyl(octanoyl) transferase activity
M876_RS11185	COG2003	Belongs to the UPF0758 family
M876_RS11205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M876_RS11235	COG1196	nuclear chromosome segregation
M876_RS11295	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M876_RS11295	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M876_RS11355	COG0551	DNA topoisomerase type I activity
M876_RS11355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M876_RS11380	COG0671	phosphoesterase, PA-phosphatase related
M876_RS11425	COG0463	Glycosyl transferase, family 2
M876_RS11430	COG0726	polysaccharide deacetylase
M876_RS11435	COG0477	Major facilitator Superfamily
M876_RS11445	COG0527	aspartate kinase activity
M876_RS11455	COG0546	phosphoglycolate phosphatase activity
M876_RS11495	COG3279	Response regulator of the LytR AlgR family
M876_RS11500	COG3275	phosphorelay sensor kinase activity
M876_RS11535	COG3781	membrane
M876_RS11615	COG1063	alcohol dehydrogenase
M876_RS11625	COG3119	arylsulfatase activity
M876_RS11655	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M876_RS11665	COG3720	iron ion transport
M876_RS11675	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M876_RS11680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M876_RS11690	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M876_RS11705	COG0577	efflux transmembrane transporter activity
M876_RS11710	COG0577	efflux transmembrane transporter activity
M876_RS11725	COG0577	efflux transmembrane transporter activity
M876_RS11725	COG1136	(ABC) transporter
M876_RS11730	COG1136	(ABC) transporter
M876_RS11750	COG2204	response regulator
M876_RS11755	COG3852	Histidine kinase
M876_RS11760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M876_RS11765	COG4771	TonB-dependent receptor
M876_RS11795	COG4753	response regulator
M876_RS11795	COG2207	Transcriptional regulator
M876_RS11805	COG4753	response regulator
M876_RS11805	COG2207	Transcriptional regulator
M876_RS11845	COG4290	ribonuclease
M876_RS11860	COG1024	Enoyl-CoA hydratase
M876_RS11875	COG2132	Multicopper oxidase
M876_RS11890	COG2814	Major facilitator Superfamily
M876_RS11905	COG1757	Na H antiporter
M876_RS11910	COG0667	Aldo Keto reductase
M876_RS11920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M876_RS11940	COG1739	Uncharacterized protein family UPF0029
M876_RS11945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M876_RS11945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M876_RS11960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M876_RS11970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M876_RS11975	COG0346	lactoylglutathione lyase activity
M876_RS12020	COG2909	trisaccharide binding
M876_RS12145	COG3634	alkyl hydroperoxide reductase activity
M876_RS12240	COG1196	nuclear chromosome segregation
M876_RS12295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M876_RS12295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M876_RS12300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M876_RS12300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M876_RS12300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M876_RS12350	COG0527	aspartate kinase activity
M876_RS12355	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M876_RS12370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M876_RS12385	COG0492	ferredoxin-NADP+ reductase activity
M876_RS12400	COG1301	dicarboxylic acid transport
M876_RS12405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M876_RS12425	COG1012	belongs to the aldehyde dehydrogenase family
M876_RS12450	COG0612	Peptidase, M16
M876_RS12455	COG3425	synthase
M876_RS12465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M876_RS12475	COG0697	spore germination
M876_RS12480	COG1187	pseudouridine synthase activity
M876_RS12485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M876_RS12500	COG0346	lactoylglutathione lyase activity
M876_RS12520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M876_RS12530	COG1022	Amp-dependent synthetase and ligase
M876_RS12540	COG2267	carboxylic ester hydrolase activity
M876_RS12550	COG0668	transmembrane transport
M876_RS12590	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M876_RS12605	COG1193	negative regulation of DNA recombination
M876_RS12665	COG2050	protein possibly involved in aromatic compounds catabolism
M876_RS12670	COG1169	isochorismate synthase
M876_RS12680	COG2095	MarC family integral membrane protein
M876_RS12695	COG2304	oxidoreductase activity
M876_RS12720	COG0714	Associated with various cellular activities
M876_RS12730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M876_RS12755	COG1309	transcriptional regulator
M876_RS12780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M876_RS12785	COG1472	Belongs to the glycosyl hydrolase 3 family
M876_RS12830	COG1522	sequence-specific DNA binding
M876_RS12840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M876_RS12850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M876_RS12865	COG0252	asparaginase activity
M876_RS12945	COG1309	transcriptional regulator
M876_RS12960	COG0784	Response regulator, receiver
M876_RS12960	COG2205	protein histidine kinase activity
M876_RS12985	COG3264	Mechanosensitive ion channel
M876_RS12985	COG1196	nuclear chromosome segregation
M876_RS13030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M876_RS13035	COG1648	precorrin-2 dehydrogenase activity
M876_RS13035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M876_RS13045	COG1045	serine acetyltransferase
M876_RS13055	COG0175	sulfate reduction
M876_RS13060	COG0175	sulfate reduction
M876_RS13065	COG1959	2 iron, 2 sulfur cluster binding
M876_RS13075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M876_RS13085	COG0297	glycogen (starch) synthase activity
M876_RS13090	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M876_RS13095	COG0456	acetyltransferase
M876_RS13115	COG0010	Belongs to the arginase family
M876_RS13140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M876_RS13165	COG1137	ATPase activity
M876_RS13190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M876_RS13205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M876_RS13210	COG1028	Short-chain dehydrogenase reductase Sdr
M876_RS13225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M876_RS13245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M876_RS13255	COG1216	Glycosyl transferase, family 2
M876_RS13270	COG0728	peptidoglycan biosynthetic process
M876_RS13295	COG2137	regulation of response to DNA damage stimulus
M876_RS13300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M876_RS13325	COG1132	(ABC) transporter
M876_RS13355	COG0438	transferase activity, transferring glycosyl groups
M876_RS13360	COG0438	transferase activity, transferring glycosyl groups
M876_RS13370	COG1442	glycosyl transferase family 8
M876_RS13370	COG1216	Glycosyl transferase, family 2
M876_RS13385	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M876_RS13395	COG0438	transferase activity, transferring glycosyl groups
M876_RS13425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M876_RS13430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M876_RS13470	COG1136	(ABC) transporter
M876_RS13475	COG1136	(ABC) transporter
M876_RS13475	COG0577	efflux transmembrane transporter activity
M876_RS13510	COG0702	epimerase
M876_RS13515	COG1629	transport
M876_RS13525	COG1418	mRNA catabolic process
M876_RS13535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M876_RS13545	COG0525	valine-tRNA ligase activity
M876_RS13555	COG3214	Protein conserved in bacteria
M876_RS13560	COG2326	polyphosphate kinase activity
M876_RS13580	COG0017	Asparaginyl-tRNA synthetase
M876_RS13600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M876_RS13605	COG0228	four-way junction DNA binding
M876_RS13615	COG1132	(ABC) transporter
M876_RS13625	COG0101	tRNA pseudouridine synthase activity
M876_RS13640	COG2249	NAD(P)H dehydrogenase (quinone) activity
M876_RS13645	COG1733	regulation of RNA biosynthetic process
M876_RS13655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M876_RS13675	COG2249	NAD(P)H dehydrogenase (quinone) activity
M876_RS13680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M876_RS13690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M876_RS13695	COG0564	pseudouridine synthase activity
M876_RS13700	COG0515	serine threonine protein kinase
M876_RS13705	COG1181	Belongs to the D-alanine--D-alanine ligase family
M876_RS13710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M876_RS13725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M876_RS13730	COG1704	LemA family
M876_RS13750	COG0475	glutathione-regulated potassium exporter activity
M876_RS13750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M876_RS13760	COG0339	signal peptide processing
M876_RS13770	COG1629	transport
M876_RS13770	COG4206	TonB-dependent receptor
M876_RS13785	COG4771	TonB-dependent receptor
M876_RS13815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M876_RS13820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M876_RS13830	COG0028	Belongs to the TPP enzyme family
M876_RS13845	COG0509	glycine decarboxylation via glycine cleavage system
M876_RS13850	COG0632	four-way junction helicase activity
M876_RS13855	COG0280	phosphate acetyltransferase
M876_RS13855	COG0281	malic enzyme
M876_RS13905	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M876_RS13915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M876_RS13920	COG1490	D-aminoacyl-tRNA deacylase activity
M876_RS13945	COG1408	metallophosphoesterase
M876_RS13985	COG2030	dehydratase
M876_RS13985	COG1012	belongs to the aldehyde dehydrogenase family
M876_RS14000	COG0183	Belongs to the thiolase family
M876_RS14010	COG1250	3-hydroxyacyl-CoA dehydrogenase
M876_RS14015	COG1024	Enoyl-CoA hydratase
M876_RS14020	COG2151	metal-sulfur cluster biosynthetic enzyme
M876_RS14025	COG1073	alpha beta
M876_RS14035	COG3460	Phenylacetate-CoA oxygenase
M876_RS14045	COG3396	Phenylacetate-CoA oxygenase
M876_RS14055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M876_RS14060	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M876_RS14075	COG3842	ATPase activity
M876_RS14080	COG0542	response to heat
M876_RS14105	COG1028	Short-chain dehydrogenase reductase Sdr
M876_RS14110	COG3537	Alpha-1,2-mannosidase
M876_RS14115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M876_RS14125	COG0756	dUTP diphosphatase activity
M876_RS14140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M876_RS14155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M876_RS14160	COG1472	Belongs to the glycosyl hydrolase 3 family
M876_RS14165	COG0438	transferase activity, transferring glycosyl groups
M876_RS14170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M876_RS14285	COG2207	Transcriptional regulator
M876_RS14320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M876_RS14360	COG3250	beta-galactosidase activity
M876_RS14365	COG0085	RNA polymerase activity
M876_RS14370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M876_RS14410	COG0366	Alpha amylase catalytic
M876_RS14415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M876_RS14485	COG0702	epimerase
M876_RS14490	COG1629	transport
M876_RS14495	COG1396	sequence-specific DNA binding
M876_RS14505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M876_RS14515	COG4585	Histidine kinase
M876_RS14535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M876_RS14555	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
M876_RS14570	COG1028	Short-chain dehydrogenase reductase Sdr
M876_RS14575	COG3618	amidohydrolase
M876_RS14580	COG3254	rhamnose metabolic process
M876_RS14585	COG0179	Fumarylacetoacetate (FAA) hydrolase
M876_RS14590	COG1028	Short-chain dehydrogenase reductase Sdr
M876_RS14595	COG2721	sulfolactate sulfo-lyase activity
M876_RS14600	COG0738	Major facilitator superfamily
M876_RS14605	COG1556	Lactate utilization protein
M876_RS14610	COG1139	Iron-sulfur cluster binding protein
M876_RS14615	COG0247	lactate metabolic process
M876_RS14635	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M876_RS14650	COG0646	methionine synthase
M876_RS14650	COG1410	methionine synthase
M876_RS14665	COG0527	aspartate kinase activity
M876_RS14665	COG0460	homoserine dehydrogenase
M876_RS14670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M876_RS14695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M876_RS14705	COG0714	Associated with various cellular activities
M876_RS14740	COG0217	transcriptional regulatory protein
M876_RS14750	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M876_RS14755	COG0488	(ABC) transporter
M876_RS14760	COG0501	Belongs to the peptidase M48B family
M876_RS14765	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M876_RS14765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M876_RS14770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M876_RS14820	COG2873	o-acetylhomoserine
M876_RS14825	COG1834	amidinotransferase
M876_RS14835	COG0148	phosphopyruvate hydratase activity
M876_RS14845	COG0203	ribosomal protein L17
M876_RS14850	COG0202	RNA polymerase activity
M876_RS14855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M876_RS14860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M876_RS14865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M876_RS14870	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M876_RS14875	COG0201	protein transport
M876_RS14880	COG0200	Binds to the 23S rRNA
M876_RS14885	COG1841	ribosomal large subunit assembly
M876_RS14890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M876_RS14895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M876_RS14900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M876_RS14905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M876_RS14910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M876_RS14915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M876_RS14920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M876_RS14925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M876_RS14930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M876_RS14935	COG0255	Belongs to the universal ribosomal protein uL29 family
M876_RS14940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M876_RS14945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M876_RS14950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M876_RS14955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M876_RS14960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M876_RS14965	COG0089	rRNA binding
M876_RS14970	COG0088	Forms part of the polypeptide exit tunnel
M876_RS14975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M876_RS15015	COG3250	beta-galactosidase activity
M876_RS15055	COG0051	transcription antitermination factor activity, RNA binding
M876_RS15060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M876_RS15065	COG0049	tRNA binding
M876_RS15070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M876_RS15080	COG0783	Belongs to the Dps family
M876_RS15085	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M876_RS15110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M876_RS15135	COG1054	Belongs to the UPF0176 family
M876_RS15140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M876_RS15145	COG0702	epimerase
M876_RS15150	COG4771	TonB-dependent receptor
M876_RS15160	COG1629	transport
M876_RS15170	COG0251	oxidation-reduction process
M876_RS15190	COG0268	Binds directly to 16S ribosomal RNA
M876_RS15215	COG1940	carbohydrate kinase activity
M876_RS15225	COG2814	Major facilitator Superfamily
M876_RS15240	COG4771	TonB-dependent receptor
M876_RS15245	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M876_RS15250	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M876_RS15265	COG1705	Flagellar rod assembly protein muramidase FlgJ
M876_RS15265	COG1388	LysM domain
M876_RS15270	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
M876_RS15285	COG4771	TonB-dependent receptor
M876_RS15325	COG1629	transport
M876_RS15340	COG4771	TonB-dependent receptor
M876_RS15350	COG4771	TonB-dependent receptor
M876_RS15355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M876_RS15360	COG0195	Participates in both transcription termination and antitermination
M876_RS15365	COG0779	Required for maturation of 30S ribosomal subunits
M876_RS15370	COG1082	Xylose isomerase domain protein TIM barrel
M876_RS15375	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M876_RS15380	COG0288	reversible hydration of carbon dioxide
M876_RS15390	COG0659	secondary active sulfate transmembrane transporter activity
M876_RS15395	COG0193	aminoacyl-tRNA hydrolase activity
M876_RS15410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M876_RS15430	COG0305	Participates in initiation and elongation during chromosome replication
M876_RS15435	COG0328	RNA-DNA hybrid ribonuclease activity
M876_RS15440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M876_RS15470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M876_RS15475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M876_RS15495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M876_RS15500	COG1611	Belongs to the LOG family
M876_RS15535	COG1629	transport
M876_RS15535	COG4206	TonB-dependent receptor
M876_RS15555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M876_RS15570	COG1024	Enoyl-CoA hydratase
M876_RS15605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M876_RS15610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M876_RS15615	COG1607	acyl-coa hydrolase
M876_RS15670	COG3279	Response regulator of the LytR AlgR family
M876_RS15675	COG3275	phosphorelay sensor kinase activity
M876_RS15695	COG1522	sequence-specific DNA binding
M876_RS15700	COG0165	Argininosuccinate lyase
M876_RS15710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M876_RS15725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M876_RS15730	COG0137	argininosuccinate synthase activity
M876_RS15740	COG0564	pseudouridine synthase activity
M876_RS15745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M876_RS15750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M876_RS15795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M876_RS15810	COG2181	nitrate reductase activity
M876_RS15810	COG0247	lactate metabolic process
M876_RS15815	COG2181	nitrate reductase activity
M876_RS15815	COG0247	lactate metabolic process
M876_RS15820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M876_RS15825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M876_RS15830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M876_RS15845	COG0166	Belongs to the GPI family
M876_RS15850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M876_RS15855	COG0602	queuosine metabolic process
M876_RS15860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M876_RS15890	COG1703	isobutyryl-CoA mutase activity
M876_RS15900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M876_RS15910	COG1690	Belongs to the RtcB family
M876_RS15920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M876_RS15920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M876_RS15925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M876_RS15935	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M876_RS15935	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M876_RS15940	COG1309	transcriptional regulator
M876_RS15945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M876_RS15960	COG4152	abc transporter atp-binding protein
M876_RS15975	COG0497	DNA recombination
M876_RS16010	COG1309	transcriptional regulator
M876_RS16020	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M876_RS16025	COG0594	ribonuclease P activity
M876_RS16050	COG3829	transcription factor binding
M876_RS16060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M876_RS16070	COG3591	Belongs to the peptidase S1B family
M876_RS16090	COG0387	Pfam Sodium calcium exchanger
M876_RS16100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M876_RS16110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M876_RS16115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M876_RS16130	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M876_RS16135	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M876_RS16145	COG1774	PSP1 C-terminal conserved region
M876_RS16160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M876_RS16165	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M876_RS16185	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M876_RS16195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M876_RS16210	COG0700	Nucleoside recognition
M876_RS16225	COG0423	glycine-tRNA ligase activity
M876_RS16230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M876_RS16250	COG0025	NhaP-type Na H and K H
M876_RS16255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M876_RS16265	COG0393	Putative heavy-metal-binding
M876_RS16270	COG0719	Fe-S assembly protein
M876_RS16280	COG0396	ATPase activity
M876_RS16285	COG0719	Fe-S assembly protein
M876_RS16290	COG0316	Belongs to the HesB IscA family
M876_RS16310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M876_RS16315	COG2733	membrane
M876_RS16335	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M876_RS16340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M876_RS16355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M876_RS16360	COG0181	hydroxymethylbilane synthase activity
M876_RS16370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M876_RS16380	COG0482	sulfurtransferase activity
M876_RS16400	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M876_RS16465	COG1792	Involved in formation and maintenance of cell shape
M876_RS16480	COG0772	Belongs to the SEDS family
M876_RS16485	COG0791	NLP P60 protein
M876_RS16565	COG4974	Belongs to the 'phage' integrase family
M876_RS16615	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
M876_RS16665	COG0481	GTPase activity
M876_RS16680	COG1595	DNA-templated transcription, initiation
M876_RS16685	COG2814	Major facilitator Superfamily
M876_RS16690	COG1733	regulation of RNA biosynthetic process
M876_RS16700	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M876_RS16705	COG0424	maF-like protein
M876_RS16710	COG1214	PFAM Peptidase M22, glycoprotease
M876_RS16715	COG4221	oxidoreductase activity
M876_RS16725	COG1619	proteins homologs of microcin C7 resistance protein MccF
M876_RS16735	COG0557	exoribonuclease II activity
M876_RS16740	COG0698	ribose 5-phosphate isomerase
M876_RS16745	COG0126	phosphoglycerate kinase activity
M876_RS16755	COG0445	tRNA wobble uridine modification
M876_RS16760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M876_RS16770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M876_RS16785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M876_RS16805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M876_RS16825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M876_RS16835	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M876_RS16835	COG3264	Mechanosensitive ion channel
M876_RS16850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M876_RS16880	COG2032	superoxide dismutase activity
M876_RS16910	COG3279	Response regulator of the LytR AlgR family
M876_RS16930	COG0363	glucosamine-6-phosphate deaminase activity
M876_RS16950	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M876_RS16985	COG0556	nucleotide-excision repair
M876_RS17000	COG3033	Beta-eliminating lyase
M876_RS17030	COG2304	oxidoreductase activity
M876_RS17040	COG1368	sulfuric ester hydrolase activity
M876_RS17045	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M876_RS17050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M876_RS17055	COG1505	serine-type exopeptidase activity
M876_RS17075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M876_RS17085	COG0653	protein targeting
M876_RS17115	COG4206	TonB-dependent receptor
M876_RS17125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M876_RS17130	COG2153	protein acetylation
M876_RS17135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M876_RS17145	COG2001	Belongs to the MraZ family
M876_RS17150	COG0275	rRNA processing
M876_RS17160	COG0768	penicillin binding
M876_RS17165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M876_RS17170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M876_RS17175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M876_RS17185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M876_RS17190	COG2827	Endonuclease containing a URI domain
M876_RS17195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M876_RS17215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M876_RS17220	COG1610	YqeY-like protein
M876_RS17235	COG0542	response to heat
M876_RS17245	COG2166	iron-sulfur cluster assembly
M876_RS17280	COG0811	peptide transport
M876_RS17300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M876_RS17305	COG3118	belongs to the thioredoxin family
M876_RS17320	COG0433	COG0433 Predicted ATPase
M876_RS17325	COG2176	DNA-directed DNA polymerase activity
M876_RS17330	COG0019	diaminopimelate decarboxylase activity
M876_RS17355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M876_RS17405	COG0606	chelatase, subunit chli
M876_RS17465	COG0606	chelatase, subunit chli
M876_RS17485	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M876_RS17485	COG0662	Cupin 2, conserved barrel domain protein
M876_RS17505	COG2151	metal-sulfur cluster biosynthetic enzyme
M876_RS17515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M876_RS17520	COG2195	Cleaves the N-terminal amino acid of tripeptides
M876_RS17530	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M876_RS17540	COG2081	HI0933 family
M876_RS17555	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M876_RS17565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M876_RS17570	COG2321	neutral zinc metallopeptidase
M876_RS17575	COG1368	sulfuric ester hydrolase activity
M876_RS17590	COG3409	Peptidoglycan-binding domain 1 protein
M876_RS17590	COG0793	Belongs to the peptidase S41A family
M876_RS17595	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M876_RS17635	COG0437	4 iron, 4 sulfur cluster binding
M876_RS17665	COG1770	oligopeptidase
M876_RS17680	COG0463	Glycosyl transferase, family 2
M876_RS17690	COG0343	queuine tRNA-ribosyltransferase activity
M876_RS17705	COG0799	negative regulation of ribosome biogenesis
M876_RS17710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M876_RS17720	COG4589	Belongs to the CDS family
M876_RS17725	COG0688	phosphatidylethanolamine metabolic process
M876_RS17735	COG1132	(ABC) transporter
M876_RS17760	COG1011	Hydrolase
M876_RS17775	COG0738	Major facilitator superfamily
M876_RS17780	COG0246	Mannitol dehydrogenase
M876_RS17785	COG1609	Transcriptional regulator
M876_RS17790	COG0180	Tryptophanyl-tRNA synthetase
M876_RS17800	COG1091	dTDP-4-dehydrorhamnose reductase activity
M876_RS17820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M876_RS17830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M876_RS17830	COG1754	DNA topoisomerase type I activity
M876_RS17835	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M876_RS17845	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M876_RS17850	COG2949	membrane
M876_RS17895	COG0732	type I restriction modification DNA specificity domain
M876_RS17935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins