locus-tag	class	description
AYC65_RS00050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AYC65_RS00100	COG4974	Belongs to the 'phage' integrase family
AYC65_RS00135	COG0280	phosphate acetyltransferase
AYC65_RS00135	COG0281	malic enzyme
AYC65_RS00140	COG0632	four-way junction helicase activity
AYC65_RS00145	COG0509	glycine decarboxylation via glycine cleavage system
AYC65_RS00160	COG0028	Belongs to the TPP enzyme family
AYC65_RS00170	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AYC65_RS00175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYC65_RS00205	COG4771	TonB-dependent receptor
AYC65_RS00220	COG4771	TonB-dependent receptor
AYC65_RS00230	COG0339	signal peptide processing
AYC65_RS00240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYC65_RS00240	COG0475	glutathione-regulated potassium exporter activity
AYC65_RS00245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AYC65_RS00260	COG1704	LemA family
AYC65_RS00265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AYC65_RS00280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AYC65_RS00285	COG1181	Belongs to the D-alanine--D-alanine ligase family
AYC65_RS00290	COG0515	serine threonine protein kinase
AYC65_RS00295	COG0564	pseudouridine synthase activity
AYC65_RS00300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AYC65_RS00310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYC65_RS00315	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYC65_RS00330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AYC65_RS00340	COG1733	regulation of RNA biosynthetic process
AYC65_RS00345	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYC65_RS00360	COG0101	tRNA pseudouridine synthase activity
AYC65_RS00370	COG1132	(ABC) transporter
AYC65_RS00385	COG0228	four-way junction DNA binding
AYC65_RS00390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AYC65_RS00410	COG0017	Asparaginyl-tRNA synthetase
AYC65_RS00435	COG2326	polyphosphate kinase activity
AYC65_RS00440	COG3214	Protein conserved in bacteria
AYC65_RS00450	COG0525	valine-tRNA ligase activity
AYC65_RS00455	COG2827	Endonuclease containing a URI domain
AYC65_RS00465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AYC65_RS00480	COG1595	DNA-templated transcription, initiation
AYC65_RS00485	COG2267	carboxylic ester hydrolase activity
AYC65_RS00490	COG1418	mRNA catabolic process
AYC65_RS00500	COG1629	transport
AYC65_RS00505	COG0702	epimerase
AYC65_RS00515	COG1472	Belongs to the glycosyl hydrolase 3 family
AYC65_RS00540	COG0577	efflux transmembrane transporter activity
AYC65_RS00540	COG1136	(ABC) transporter
AYC65_RS00545	COG1136	(ABC) transporter
AYC65_RS00585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AYC65_RS00590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYC65_RS00605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AYC65_RS00630	COG1216	Glycosyl transferase, family 2
AYC65_RS00635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYC65_RS00640	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AYC65_RS00670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AYC65_RS00675	COG0110	maltose O-acetyltransferase activity
AYC65_RS00690	COG1216	Glycosyl transferase, family 2
AYC65_RS00695	COG1442	glycosyl transferase family 8
AYC65_RS00700	COG1216	Glycosyl transferase, family 2
AYC65_RS00700	COG1442	glycosyl transferase family 8
AYC65_RS00705	COG0463	Glycosyl transferase, family 2
AYC65_RS00715	COG0438	transferase activity, transferring glycosyl groups
AYC65_RS00720	COG0438	transferase activity, transferring glycosyl groups
AYC65_RS00725	COG0438	transferase activity, transferring glycosyl groups
AYC65_RS00750	COG1132	(ABC) transporter
AYC65_RS00775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AYC65_RS00810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYC65_RS00845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AYC65_RS00875	COG1137	ATPase activity
AYC65_RS00880	COG1132	(ABC) transporter
AYC65_RS00885	COG2096	Adenosyltransferase
AYC65_RS00900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYC65_RS00925	COG0010	Belongs to the arginase family
AYC65_RS00945	COG0456	acetyltransferase
AYC65_RS00950	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AYC65_RS00955	COG0297	glycogen (starch) synthase activity
AYC65_RS00965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AYC65_RS00975	COG1959	2 iron, 2 sulfur cluster binding
AYC65_RS00980	COG0175	sulfate reduction
AYC65_RS00985	COG0175	sulfate reduction
AYC65_RS00995	COG1045	serine acetyltransferase
AYC65_RS01005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AYC65_RS01005	COG1648	precorrin-2 dehydrogenase activity
AYC65_RS01010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AYC65_RS01075	COG0784	Response regulator, receiver
AYC65_RS01075	COG2205	protein histidine kinase activity
AYC65_RS01090	COG1309	transcriptional regulator
AYC65_RS01115	COG0252	asparaginase activity
AYC65_RS01130	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AYC65_RS01140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AYC65_RS01150	COG1522	sequence-specific DNA binding
AYC65_RS01215	COG1472	Belongs to the glycosyl hydrolase 3 family
AYC65_RS01220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AYC65_RS01245	COG1309	transcriptional regulator
AYC65_RS01270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYC65_RS01280	COG0714	Associated with various cellular activities
AYC65_RS01285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AYC65_RS01305	COG2304	oxidoreductase activity
AYC65_RS01320	COG2095	MarC family integral membrane protein
AYC65_RS01330	COG1169	isochorismate synthase
AYC65_RS01335	COG2050	protein possibly involved in aromatic compounds catabolism
AYC65_RS01385	COG1193	negative regulation of DNA recombination
AYC65_RS01390	COG5492	domain, Protein
AYC65_RS01395	COG5492	domain, Protein
AYC65_RS01400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AYC65_RS01435	COG0668	transmembrane transport
AYC65_RS01445	COG2267	carboxylic ester hydrolase activity
AYC65_RS01455	COG1022	Amp-dependent synthetase and ligase
AYC65_RS01465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYC65_RS01485	COG0346	lactoylglutathione lyase activity
AYC65_RS01500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AYC65_RS01505	COG1187	pseudouridine synthase activity
AYC65_RS01510	COG0697	spore germination
AYC65_RS01520	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AYC65_RS01530	COG3425	synthase
AYC65_RS01555	COG1012	belongs to the aldehyde dehydrogenase family
AYC65_RS01575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AYC65_RS01580	COG1301	dicarboxylic acid transport
AYC65_RS01595	COG0492	ferredoxin-NADP+ reductase activity
AYC65_RS01610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYC65_RS01625	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AYC65_RS01630	COG0527	aspartate kinase activity
AYC65_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS01815	COG3634	alkyl hydroperoxide reductase activity
AYC65_RS01875	COG4122	O-methyltransferase activity
AYC65_RS01925	COG0025	NhaP-type Na H and K H
AYC65_RS01940	COG0589	response to stress
AYC65_RS01955	COG2814	Major facilitator Superfamily
AYC65_RS01965	COG2909	trisaccharide binding
AYC65_RS02000	COG0346	lactoylglutathione lyase activity
AYC65_RS02005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AYC65_RS02015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AYC65_RS02025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYC65_RS02025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYC65_RS02030	COG1739	Uncharacterized protein family UPF0029
AYC65_RS02040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AYC65_RS02050	COG0667	Aldo Keto reductase
AYC65_RS02055	COG1757	Na H antiporter
AYC65_RS02070	COG2814	Major facilitator Superfamily
AYC65_RS02110	COG2079	MmgE PrpD family protein
AYC65_RS02120	COG1960	acyl-CoA dehydrogenase activity
AYC65_RS02125	COG1024	Enoyl-CoA hydratase
AYC65_RS02135	COG1024	Enoyl-CoA hydratase
AYC65_RS02140	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AYC65_RS02155	COG4290	ribonuclease
AYC65_RS02180	COG4771	TonB-dependent receptor
AYC65_RS02200	COG4753	response regulator
AYC65_RS02200	COG2207	Transcriptional regulator
AYC65_RS02210	COG2207	Transcriptional regulator
AYC65_RS02210	COG4753	response regulator
AYC65_RS02275	COG1629	transport
AYC65_RS02280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AYC65_RS02285	COG3852	Histidine kinase
AYC65_RS02310	COG1136	(ABC) transporter
AYC65_RS02315	COG1136	(ABC) transporter
AYC65_RS02315	COG0577	efflux transmembrane transporter activity
AYC65_RS02325	COG0577	efflux transmembrane transporter activity
AYC65_RS02325	COG1136	(ABC) transporter
AYC65_RS02330	COG0577	efflux transmembrane transporter activity
AYC65_RS02335	COG0577	efflux transmembrane transporter activity
AYC65_RS02355	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AYC65_RS02365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYC65_RS02370	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AYC65_RS02375	COG2226	methyltransferase
AYC65_RS02380	COG3720	iron ion transport
AYC65_RS02410	COG4206	TonB-dependent receptor
AYC65_RS02410	COG1629	transport
AYC65_RS02415	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AYC65_RS02420	COG1215	transferase activity, transferring glycosyl groups
AYC65_RS02425	COG3119	arylsulfatase activity
AYC65_RS02525	COG0477	Major facilitator Superfamily
AYC65_RS02535	COG3781	membrane
AYC65_RS02550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AYC65_RS02565	COG3275	phosphorelay sensor kinase activity
AYC65_RS02570	COG3279	Response regulator of the LytR AlgR family
AYC65_RS02605	COG0527	aspartate kinase activity
AYC65_RS02620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AYC65_RS02640	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AYC65_RS02660	COG0387	Pfam Sodium calcium exchanger
AYC65_RS02670	COG0513	Belongs to the DEAD box helicase family
AYC65_RS02675	COG1278	Cold shock
AYC65_RS02690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYC65_RS02925	COG3561	AntA/AntB antirepressor
AYC65_RS03055	COG3179	chitinase
AYC65_RS03080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AYC65_RS03085	COG2135	peptidase activity
AYC65_RS03105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AYC65_RS03105	COG0321	lipoyl(octanoyl) transferase activity
AYC65_RS03120	COG3813	Protein conserved in bacteria
AYC65_RS03125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AYC65_RS03130	COG2239	Acts as a magnesium transporter
AYC65_RS03140	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AYC65_RS03150	COG1185	polyribonucleotide nucleotidyltransferase activity
AYC65_RS03170	COG0837	glucose binding
AYC65_RS03190	COG2827	Endonuclease containing a URI domain
AYC65_RS03195	COG1760	l-serine dehydratase
AYC65_RS03210	COG0287	Prephenate dehydrogenase
AYC65_RS03215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AYC65_RS03215	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AYC65_RS03230	COG0802	atpase or kinase
AYC65_RS03245	COG1078	dGTPase activity
AYC65_RS03250	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYC65_RS03255	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AYC65_RS03255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AYC65_RS03260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYC65_RS03265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AYC65_RS03270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYC65_RS03275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AYC65_RS03290	COG4152	abc transporter atp-binding protein
AYC65_RS03295	COG1446	asparaginase
AYC65_RS03300	COG2104	thiamine diphosphate biosynthetic process
AYC65_RS03315	COG0352	thiamine-phosphate diphosphorylase activity
AYC65_RS03320	COG2022	thiamine diphosphate biosynthetic process
AYC65_RS03325	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AYC65_RS03355	COG1285	pathogenesis
AYC65_RS03375	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AYC65_RS03390	COG2207	Transcriptional regulator
AYC65_RS03390	COG4753	response regulator
AYC65_RS03410	COG3118	belongs to the thioredoxin family
AYC65_RS03420	COG0456	acetyltransferase
AYC65_RS03430	COG5006	permease, DMT superfamily
AYC65_RS03435	COG0456	acetyltransferase
AYC65_RS03440	COG5002	protein histidine kinase activity
AYC65_RS03445	COG0745	RESPONSE REGULATOR receiver
AYC65_RS03460	COG1629	transport
AYC65_RS03485	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AYC65_RS03565	COG1335	isochorismatase
AYC65_RS03580	COG0288	reversible hydration of carbon dioxide
AYC65_RS03610	COG0798	PFAM Bile acid sodium symporter
AYC65_RS03615	COG1764	response to oxidative stress
AYC65_RS03640	COG0730	response to heat
AYC65_RS03650	COG0596	Alpha beta hydrolase
AYC65_RS03690	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AYC65_RS03700	COG1595	DNA-templated transcription, initiation
AYC65_RS03715	COG3548	integral membrane protein
AYC65_RS03720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYC65_RS03725	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AYC65_RS03725	COG2755	lipolytic protein G-D-S-L family
AYC65_RS03735	COG1673	EVE domain
AYC65_RS03755	COG2723	6-phospho-beta-galactosidase activity
AYC65_RS03790	COG2226	methyltransferase
AYC65_RS03800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYC65_RS03805	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AYC65_RS03815	COG0484	heat shock protein binding
AYC65_RS03820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AYC65_RS03845	COG0442	prolyl-tRNA aminoacylation
AYC65_RS03885	COG0116	Belongs to the methyltransferase superfamily
AYC65_RS03900	COG4221	oxidoreductase activity
AYC65_RS03910	COG1473	amidohydrolase
AYC65_RS03920	COG0022	dehydrogenase e1 component
AYC65_RS03970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYC65_RS03990	COG2910	NAD(P)H-binding
AYC65_RS04040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYC65_RS04050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYC65_RS04075	COG0745	RESPONSE REGULATOR receiver
AYC65_RS04080	COG5002	protein histidine kinase activity
AYC65_RS04105	COG2851	Citrate transporter
AYC65_RS04110	COG1301	dicarboxylic acid transport
AYC65_RS04115	COG0861	Integral membrane protein TerC family
AYC65_RS04120	COG0363	glucosamine-6-phosphate deaminase activity
AYC65_RS04125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AYC65_RS04130	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AYC65_RS04135	COG1733	regulation of RNA biosynthetic process
AYC65_RS04160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AYC65_RS04160	COG0551	DNA topoisomerase type I activity
AYC65_RS04220	COG1566	PFAM secretion protein HlyD family protein
AYC65_RS04295	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AYC65_RS04460	COG0629	single-stranded DNA binding
AYC65_RS04465	COG4974	Belongs to the 'phage' integrase family
AYC65_RS04470	COG1733	regulation of RNA biosynthetic process
AYC65_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS04510	COG1335	isochorismatase
AYC65_RS04520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AYC65_RS04530	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS04535	COG1131	(ABC) transporter
AYC65_RS04605	COG1629	transport
AYC65_RS04610	COG3279	Response regulator of the LytR AlgR family
AYC65_RS04615	COG3275	phosphorelay sensor kinase activity
AYC65_RS04630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYC65_RS04645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AYC65_RS04695	COG2837	iron assimilation
AYC65_RS04710	COG1733	regulation of RNA biosynthetic process
AYC65_RS04715	COG1428	Deoxynucleoside kinase
AYC65_RS04735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AYC65_RS04745	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AYC65_RS04770	COG2267	carboxylic ester hydrolase activity
AYC65_RS04825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AYC65_RS04830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AYC65_RS04845	COG0531	amino acid
AYC65_RS04855	COG2706	6-phosphogluconolactonase activity
AYC65_RS04870	COG1575	Belongs to the MenA family. Type 1 subfamily
AYC65_RS04880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AYC65_RS04905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYC65_RS04915	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AYC65_RS04925	COG0386	Belongs to the glutathione peroxidase family
AYC65_RS04935	COG3250	beta-galactosidase activity
AYC65_RS04945	COG0196	riboflavin kinase activity
AYC65_RS04950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AYC65_RS04955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AYC65_RS04975	COG1696	Membrane protein involved in D-alanine export
AYC65_RS04995	COG0156	8-amino-7-oxononanoate synthase activity
AYC65_RS05015	COG2076	Multidrug Resistance protein
AYC65_RS05040	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AYC65_RS05055	COG0805	protein transport
AYC65_RS05060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AYC65_RS05060	COG0517	IMP dehydrogenase activity
AYC65_RS05065	COG0514	ATP-dependent DNA helicase (RecQ)
AYC65_RS05075	COG0724	RNA recognition motif
AYC65_RS05090	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AYC65_RS05090	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AYC65_RS05095	COG0069	glutamate synthase activity
AYC65_RS05095	COG0070	glutamate synthase
AYC65_RS05095	COG0067	glutamate synthase
AYC65_RS05105	COG1090	epimerase
AYC65_RS05110	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AYC65_RS05120	COG3279	Response regulator of the LytR AlgR family
AYC65_RS05125	COG3275	phosphorelay sensor kinase activity
AYC65_RS05145	COG0673	inositol 2-dehydrogenase activity
AYC65_RS05150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AYC65_RS05155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AYC65_RS05160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AYC65_RS05165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AYC65_RS05175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AYC65_RS05180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AYC65_RS05185	COG0066	3-isopropylmalate dehydratase activity
AYC65_RS05205	COG1960	acyl-CoA dehydrogenase activity
AYC65_RS05210	COG1119	ATPase activity
AYC65_RS05235	COG0793	Belongs to the peptidase S41A family
AYC65_RS05235	COG3409	Peptidoglycan-binding domain 1 protein
AYC65_RS05255	COG0539	negative regulation of cytoplasmic translation
AYC65_RS05255	COG2183	response to ionizing radiation
AYC65_RS05270	COG0004	ammonium transporteR
AYC65_RS05275	COG0477	Major facilitator Superfamily
AYC65_RS05290	COG2207	Transcriptional regulator
AYC65_RS05295	COG0494	nUDIX hydrolase
AYC65_RS05300	COG0335	large ribosomal subunit rRNA binding
AYC65_RS05335	COG0563	adenylate kinase activity
AYC65_RS05340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYC65_RS05360	COG2207	Transcriptional regulator
AYC65_RS05410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AYC65_RS05415	COG0028	Belongs to the TPP enzyme family
AYC65_RS05435	COG0745	RESPONSE REGULATOR receiver
AYC65_RS05445	COG0629	single-stranded DNA binding
AYC65_RS05450	COG0124	histidyl-tRNA synthetase
AYC65_RS05475	COG1733	regulation of RNA biosynthetic process
AYC65_RS05480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AYC65_RS05495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AYC65_RS05500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AYC65_RS05505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AYC65_RS05510	COG1349	DNA-binding transcription factor activity
AYC65_RS05515	COG1629	transport
AYC65_RS05520	COG0702	epimerase
AYC65_RS05530	COG3511	phospholipase C
AYC65_RS05540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AYC65_RS05560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYC65_RS05565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AYC65_RS05575	COG1506	peptidase
AYC65_RS05575	COG0823	Involved in the tonB-independent uptake of proteins
AYC65_RS05585	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AYC65_RS05590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYC65_RS05595	COG2027	D-alanyl-D-alanine carboxypeptidase
AYC65_RS05605	COG0584	glycerophosphoryl diester phosphodiesterase
AYC65_RS05610	COG0671	phosphoesterase, PA-phosphatase related
AYC65_RS05615	COG2217	Heavy metal translocating P-type atpase
AYC65_RS05630	COG1607	acyl-coa hydrolase
AYC65_RS05635	COG0069	glutamate synthase activity
AYC65_RS05650	COG0359	binds to the 23S rRNA
AYC65_RS05655	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AYC65_RS05660	COG0360	Binds together with S18 to 16S ribosomal RNA
AYC65_RS05685	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AYC65_RS05715	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYC65_RS05720	COG0321	lipoyl(octanoyl) transferase activity
AYC65_RS05725	COG0745	RESPONSE REGULATOR receiver
AYC65_RS05750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AYC65_RS05750	COG3153	acetyltransferase
AYC65_RS05765	COG0534	Mate efflux family protein
AYC65_RS05775	COG4585	Histidine kinase
AYC65_RS05780	COG2197	response regulator
AYC65_RS05815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AYC65_RS05825	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AYC65_RS05835	COG1022	Amp-dependent synthetase and ligase
AYC65_RS05840	COG1960	acyl-CoA dehydrogenase activity
AYC65_RS05850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AYC65_RS05855	COG2207	Transcriptional regulator
AYC65_RS05865	COG1566	PFAM secretion protein HlyD family protein
AYC65_RS05885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYC65_RS05885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYC65_RS05905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AYC65_RS05915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AYC65_RS05920	COG2027	D-alanyl-D-alanine carboxypeptidase
AYC65_RS05925	COG0156	8-amino-7-oxononanoate synthase activity
AYC65_RS05945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AYC65_RS05950	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AYC65_RS05970	COG2197	response regulator
AYC65_RS05985	COG0022	dehydrogenase e1 component
AYC65_RS05995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYC65_RS06000	COG1752	Esterase of the alpha-beta hydrolase superfamily
AYC65_RS06020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AYC65_RS06025	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AYC65_RS06030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AYC65_RS06070	COG1321	iron dependent repressor
AYC65_RS06090	COG0519	Catalyzes the synthesis of GMP from XMP
AYC65_RS06105	COG0813	purine-nucleoside phosphorylase activity
AYC65_RS06115	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AYC65_RS06120	COG0456	acetyltransferase
AYC65_RS06140	COG2226	methyltransferase
AYC65_RS06145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AYC65_RS06155	COG1506	peptidase
AYC65_RS06165	COG0488	(ABC) transporter
AYC65_RS06170	COG1113	amino acid transport
AYC65_RS06185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AYC65_RS06205	COG4974	Belongs to the 'phage' integrase family
AYC65_RS06310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AYC65_RS06390	COG3781	membrane
AYC65_RS06455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYC65_RS06475	COG4654	Cytochrome c, class I
AYC65_RS06485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AYC65_RS06505	COG0667	Aldo Keto reductase
AYC65_RS06515	COG2814	Major facilitator Superfamily
AYC65_RS06535	COG1271	oxidase subunit
AYC65_RS06540	COG0187	DNA topoisomerase II activity
AYC65_RS06550	COG3279	Response regulator of the LytR AlgR family
AYC65_RS06590	COG1538	Outer membrane efflux protein
AYC65_RS06600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYC65_RS06625	COG3279	Response regulator of the LytR AlgR family
AYC65_RS06695	COG0431	NADPH-dependent FMN reductase
AYC65_RS06700	COG0346	lactoylglutathione lyase activity
AYC65_RS06735	COG1131	(ABC) transporter
AYC65_RS06755	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AYC65_RS06760	COG0076	glutamate decarboxylase activity
AYC65_RS06765	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AYC65_RS06770	COG2211	Major facilitator Superfamily
AYC65_RS06785	COG1960	acyl-CoA dehydrogenase activity
AYC65_RS06805	COG2197	response regulator
AYC65_RS06820	COG3012	SEC-C Motif Domain Protein
AYC65_RS06830	COG1280	lysine exporter protein (LysE YggA)
AYC65_RS06855	COG0436	Aminotransferase
AYC65_RS06860	COG0012	GTP binding
AYC65_RS06880	COG0357	Ribosomal RNA small subunit methyltransferase G
AYC65_RS06885	COG0436	Aminotransferase
AYC65_RS06890	COG0612	Peptidase, M16
AYC65_RS06895	COG0450	alkyl hydroperoxide reductase
AYC65_RS06910	COG1803	Methylglyoxal synthase
AYC65_RS06940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AYC65_RS06945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AYC65_RS06955	COG0105	UTP biosynthetic process
AYC65_RS06960	COG2270	Major facilitator Superfamily
AYC65_RS06965	COG0183	Belongs to the thiolase family
AYC65_RS06975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AYC65_RS06980	COG0083	homoserine kinase activity
AYC65_RS06985	COG0527	aspartate kinase activity
AYC65_RS06985	COG0460	homoserine dehydrogenase
AYC65_RS06990	COG2211	Major facilitator Superfamily
AYC65_RS07000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AYC65_RS07010	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS07030	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AYC65_RS07030	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AYC65_RS07040	COG0572	uridine kinase
AYC65_RS07065	COG2949	membrane
AYC65_RS07070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYC65_RS07070	COG1017	nitric oxide dioxygenase activity
AYC65_RS07075	COG3118	belongs to the thioredoxin family
AYC65_RS07085	COG1120	ATPase activity
AYC65_RS07095	COG1024	Enoyl-CoA hydratase
AYC65_RS07095	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYC65_RS07105	COG0183	Belongs to the thiolase family
AYC65_RS07115	COG1960	acyl-CoA dehydrogenase activity
AYC65_RS07145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AYC65_RS07150	COG1968	undecaprenyl-diphosphatase activity
AYC65_RS07160	COG2177	Part of the ABC transporter FtsEX involved in
AYC65_RS07165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AYC65_RS07175	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AYC65_RS07190	COG0670	Belongs to the BI1 family
AYC65_RS07205	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYC65_RS07215	COG1234	tRNA 3'-trailer cleavage
AYC65_RS07220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AYC65_RS07250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AYC65_RS07255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYC65_RS07260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AYC65_RS07270	COG3340	Belongs to the peptidase S51 family
AYC65_RS07275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AYC65_RS07300	COG1506	peptidase
AYC65_RS07300	COG4946	Tricorn protease homolog
AYC65_RS07300	COG0823	Involved in the tonB-independent uptake of proteins
AYC65_RS07305	COG0006	proline dipeptidase activity
AYC65_RS07310	COG2207	Transcriptional regulator
AYC65_RS07315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYC65_RS07325	COG3938	Belongs to the proline racemase family
AYC65_RS07330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYC65_RS07380	COG1629	transport
AYC65_RS07380	COG4206	TonB-dependent receptor
AYC65_RS07385	COG0295	cytidine deaminase activity
AYC65_RS07390	COG4771	TonB-dependent receptor
AYC65_RS07395	COG1295	ribonuclease BN
AYC65_RS07400	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AYC65_RS07405	COG0671	phosphoesterase, PA-phosphatase related
AYC65_RS07420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AYC65_RS07420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AYC65_RS07435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AYC65_RS07445	COG0531	amino acid
AYC65_RS07455	COG1217	gtp-binding protein TYPA
AYC65_RS07525	COG0303	'Molybdopterin
AYC65_RS07535	COG0315	cyclic pyranopterin monophosphate synthase activity
AYC65_RS07540	COG0315	cyclic pyranopterin monophosphate synthase activity
AYC65_RS07540	COG0746	molybdenum cofactor guanylyltransferase activity
AYC65_RS07545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AYC65_RS07555	COG3781	membrane
AYC65_RS07575	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AYC65_RS07580	COG0314	molybdopterin synthase activity
AYC65_RS07655	COG0531	amino acid
AYC65_RS07665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AYC65_RS07675	COG0512	Glutamine amidotransferase of anthranilate synthase
AYC65_RS07680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AYC65_RS07685	COG0134	indole-3-glycerol-phosphate synthase activity
AYC65_RS07690	COG0135	phosphoribosylanthranilate isomerase activity
AYC65_RS07695	COG0133	tryptophan synthase activity
AYC65_RS07700	COG0159	tryptophan synthase activity
AYC65_RS07720	COG0463	Glycosyl transferase, family 2
AYC65_RS07730	COG2171	N-acyltransferase activity
AYC65_RS07735	COG0791	NLP P60 protein
AYC65_RS07785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYC65_RS07805	COG1012	belongs to the aldehyde dehydrogenase family
AYC65_RS07820	COG0745	RESPONSE REGULATOR receiver
AYC65_RS07890	COG2855	membrane
AYC65_RS07895	COG0583	DNA-binding transcription factor activity
AYC65_RS07910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AYC65_RS07935	COG0505	Belongs to the CarA family
AYC65_RS07945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYC65_RS07965	COG0077	Prephenate dehydratase
AYC65_RS07970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AYC65_RS07980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AYC65_RS07985	COG1970	mechanosensitive ion channel activity
AYC65_RS07990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AYC65_RS08015	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AYC65_RS08020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AYC65_RS08080	COG0009	L-threonylcarbamoyladenylate synthase
AYC65_RS08085	COG3022	response to hydroperoxide
AYC65_RS08090	COG2890	protein-(glutamine-N5) methyltransferase activity
AYC65_RS08110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AYC65_RS08115	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AYC65_RS08115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYC65_RS08135	COG1363	Peptidase, m42
AYC65_RS08140	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYC65_RS08160	COG0242	peptide deformylase activity
AYC65_RS08170	COG3118	belongs to the thioredoxin family
AYC65_RS08175	COG2318	DinB family
AYC65_RS08180	COG1335	isochorismatase
AYC65_RS08195	COG1187	pseudouridine synthase activity
AYC65_RS08220	COG1162	GTPase activity
AYC65_RS08225	COG1605	Chorismate mutase
AYC65_RS08225	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AYC65_RS08235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AYC65_RS08240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AYC65_RS08245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AYC65_RS08250	COG2003	Belongs to the UPF0758 family
AYC65_RS08290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AYC65_RS08295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AYC65_RS08320	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AYC65_RS08325	COG3153	acetyltransferase
AYC65_RS08335	COG1979	alcohol dehydrogenase
AYC65_RS08355	COG0513	Belongs to the DEAD box helicase family
AYC65_RS08365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AYC65_RS08380	COG0519	Catalyzes the synthesis of GMP from XMP
AYC65_RS08380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYC65_RS08385	COG0151	Belongs to the GarS family
AYC65_RS08400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AYC65_RS08405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AYC65_RS08415	COG1741	Belongs to the pirin family
AYC65_RS08425	COG1082	Xylose isomerase domain protein TIM barrel
AYC65_RS08430	COG3408	Glycogen debranching enzyme
AYC65_RS08430	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AYC65_RS08440	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AYC65_RS08445	COG1629	transport
AYC65_RS08445	COG4206	TonB-dependent receptor
AYC65_RS08450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AYC65_RS08455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AYC65_RS08465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AYC65_RS08470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AYC65_RS08475	COG2133	pyrroloquinoline quinone binding
AYC65_RS08510	COG0697	spore germination
AYC65_RS08515	COG2967	ApaG domain
AYC65_RS08520	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYC65_RS08535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AYC65_RS08540	COG0297	glycogen (starch) synthase activity
AYC65_RS08545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AYC65_RS08575	COG0346	lactoylglutathione lyase activity
AYC65_RS08585	COG0667	Aldo Keto reductase
AYC65_RS08590	COG2814	Major facilitator Superfamily
AYC65_RS08595	COG0583	DNA-binding transcription factor activity
AYC65_RS08600	COG3537	Alpha-1,2-mannosidase
AYC65_RS08610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AYC65_RS08615	COG0598	Magnesium transport protein CorA
AYC65_RS08650	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AYC65_RS08655	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYC65_RS08665	COG1289	transmembrane transporter activity
AYC65_RS08675	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AYC65_RS08705	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AYC65_RS08715	COG0025	NhaP-type Na H and K H
AYC65_RS08720	COG3781	membrane
AYC65_RS08735	COG1846	Transcriptional regulator
AYC65_RS08740	COG1764	response to oxidative stress
AYC65_RS08750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AYC65_RS08765	COG0702	epimerase
AYC65_RS08775	COG1073	alpha beta
AYC65_RS08780	COG1073	alpha beta
AYC65_RS08805	COG1733	regulation of RNA biosynthetic process
AYC65_RS08825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AYC65_RS08830	COG0456	acetyltransferase
AYC65_RS08850	COG3292	Two component regulator propeller
AYC65_RS08850	COG2205	protein histidine kinase activity
AYC65_RS08850	COG0745	RESPONSE REGULATOR receiver
AYC65_RS08855	COG1611	Belongs to the LOG family
AYC65_RS08875	COG0534	Mate efflux family protein
AYC65_RS08880	COG2375	cellular response to nickel ion
AYC65_RS08885	COG2207	Transcriptional regulator
AYC65_RS08885	COG0662	Cupin 2, conserved barrel domain protein
AYC65_RS08905	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AYC65_RS08925	COG0523	cobalamin synthesis protein
AYC65_RS08930	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS09010	COG4771	TonB-dependent receptor
AYC65_RS09045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYC65_RS09065	COG3781	membrane
AYC65_RS09135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AYC65_RS09155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AYC65_RS09160	COG0656	L-ascorbic acid biosynthetic process
AYC65_RS09170	COG0242	peptide deformylase activity
AYC65_RS09175	COG0024	Methionine aminopeptidase
AYC65_RS09195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AYC65_RS09265	COG0519	Catalyzes the synthesis of GMP from XMP
AYC65_RS09270	COG0300	oxidoreductase activity
AYC65_RS09300	COG0415	Belongs to the DNA photolyase family
AYC65_RS09340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AYC65_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS09385	COG2197	response regulator
AYC65_RS09415	COG4771	TonB-dependent receptor
AYC65_RS09425	COG0431	NADPH-dependent FMN reductase
AYC65_RS09440	COG2957	Belongs to the agmatine deiminase family
AYC65_RS09445	COG3279	Response regulator of the LytR AlgR family
AYC65_RS09450	COG3275	phosphorelay sensor kinase activity
AYC65_RS09470	COG2207	Transcriptional regulator
AYC65_RS09485	COG0778	Nitroreductase
AYC65_RS09495	COG1733	regulation of RNA biosynthetic process
AYC65_RS09500	COG1733	regulation of RNA biosynthetic process
AYC65_RS09510	COG1785	Belongs to the alkaline phosphatase family
AYC65_RS09515	COG2076	Multidrug Resistance protein
AYC65_RS09585	COG0348	domain, Protein
AYC65_RS09590	COG2207	Transcriptional regulator
AYC65_RS09590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AYC65_RS09595	COG0745	RESPONSE REGULATOR receiver
AYC65_RS09600	COG5002	protein histidine kinase activity
AYC65_RS09625	COG0671	phosphoesterase, PA-phosphatase related
AYC65_RS09655	COG2194	sulfuric ester hydrolase activity
AYC65_RS09665	COG3059	membrane
AYC65_RS09670	COG2814	Major facilitator Superfamily
AYC65_RS09675	COG1234	tRNA 3'-trailer cleavage
AYC65_RS09680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AYC65_RS09685	COG1999	signal sequence binding
AYC65_RS09700	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS09715	COG1064	alcohol dehydrogenase
AYC65_RS09775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYC65_RS09785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AYC65_RS09790	COG0697	spore germination
AYC65_RS09795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYC65_RS09820	COG0596	Alpha beta hydrolase
AYC65_RS09835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AYC65_RS09850	COG1335	isochorismatase
AYC65_RS09855	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AYC65_RS09860	COG1335	isochorismatase
AYC65_RS09870	COG1741	Belongs to the pirin family
AYC65_RS09880	COG1741	Belongs to the pirin family
AYC65_RS09895	COG0025	NhaP-type Na H and K H
AYC65_RS09910	COG0346	lactoylglutathione lyase activity
AYC65_RS09920	COG0346	lactoylglutathione lyase activity
AYC65_RS09930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AYC65_RS09990	COG0542	response to heat
AYC65_RS10060	COG2197	response regulator
AYC65_RS10065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYC65_RS10075	COG2169	Transcriptional regulator
AYC65_RS10085	COG2827	Endonuclease containing a URI domain
AYC65_RS10100	COG1104	cysteine desulfurase activity
AYC65_RS10110	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AYC65_RS10115	COG2885	chlorophyll binding
AYC65_RS10135	COG0681	Belongs to the peptidase S26 family
AYC65_RS10140	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AYC65_RS10150	COG1475	DNA binding
AYC65_RS10155	COG1192	Involved in chromosome partitioning
AYC65_RS10165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AYC65_RS10170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AYC65_RS10185	COG0306	phosphate transporter
AYC65_RS10200	COG0084	hydrolase, TatD family'
AYC65_RS10210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AYC65_RS10215	COG0513	Belongs to the DEAD box helicase family
AYC65_RS10220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AYC65_RS10225	COG0563	adenylate kinase activity
AYC65_RS10230	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AYC65_RS10265	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYC65_RS10270	COG2011	ABC-type metal ion transport system permease component
AYC65_RS10275	COG1464	Belongs to the NlpA lipoprotein family
AYC65_RS10285	COG4677	pectinesterase activity
AYC65_RS10290	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AYC65_RS10315	COG0463	Glycosyl transferase, family 2
AYC65_RS10315	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AYC65_RS10320	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AYC65_RS10320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AYC65_RS10340	COG3345	alpha-galactosidase
AYC65_RS10355	COG4935	Belongs to the peptidase S8 family
AYC65_RS10355	COG2234	aminopeptidase activity
AYC65_RS10380	COG1335	isochorismatase
AYC65_RS10390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AYC65_RS10415	COG1418	mRNA catabolic process
AYC65_RS10430	COG2226	methyltransferase
AYC65_RS10440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AYC65_RS10455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYC65_RS10460	COG0405	Gamma-glutamyltransferase
AYC65_RS10475	COG4574	serine-type endopeptidase inhibitor activity
AYC65_RS10485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AYC65_RS10505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AYC65_RS10525	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYC65_RS10545	COG0592	DNA-directed DNA polymerase activity
AYC65_RS10560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AYC65_RS10580	COG1702	phosphate starvation-inducible protein PhoH
AYC65_RS10595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AYC65_RS10630	COG1741	Belongs to the pirin family
AYC65_RS10635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AYC65_RS10640	COG0477	Major facilitator Superfamily
AYC65_RS10645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AYC65_RS10650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AYC65_RS10655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AYC65_RS10660	COG0131	Imidazoleglycerol-phosphate dehydratase
AYC65_RS10675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AYC65_RS10685	COG0107	imidazoleglycerol-phosphate synthase activity
AYC65_RS10690	COG0140	phosphoribosyl-ATP diphosphatase activity
AYC65_RS10690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AYC65_RS10715	COG0730	response to heat
AYC65_RS10725	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AYC65_RS10740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYC65_RS10740	COG2169	Transcriptional regulator
AYC65_RS10765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYC65_RS10770	COG3384	dioxygenase
AYC65_RS10775	COG2353	YceI-like domain
AYC65_RS10795	COG2814	Major facilitator Superfamily
AYC65_RS10800	COG3781	membrane
AYC65_RS10810	COG2378	regulation of single-species biofilm formation
AYC65_RS10820	COG0612	Peptidase, M16
AYC65_RS10825	COG0612	Peptidase, M16
AYC65_RS10830	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AYC65_RS10835	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AYC65_RS10885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AYC65_RS10900	COG1194	a g-specific adenine glycosylase
AYC65_RS10905	COG0776	regulation of translation
AYC65_RS10910	COG1530	ribonuclease E activity
AYC65_RS10925	COG2268	Band 7 protein
AYC65_RS10935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYC65_RS10950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AYC65_RS10960	COG3609	addiction module antidote protein, CC2985 family
AYC65_RS10975	COG0427	acetyl-CoA hydrolase
AYC65_RS10980	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AYC65_RS11015	COG3590	peptidase
AYC65_RS11030	COG3590	peptidase
AYC65_RS11045	COG1058	Belongs to the CinA family
AYC65_RS11045	COG1546	Belongs to the CinA family
AYC65_RS11075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYC65_RS11090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AYC65_RS11110	COG0596	Alpha beta hydrolase
AYC65_RS11120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYC65_RS11140	COG5002	protein histidine kinase activity
AYC65_RS11145	COG0745	RESPONSE REGULATOR receiver
AYC65_RS11160	COG2732	(Barnase) inhibitor
AYC65_RS11170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AYC65_RS11190	COG0626	cystathionine gamma-synthase activity
AYC65_RS11195	COG0009	L-threonylcarbamoyladenylate synthase
AYC65_RS11200	COG0517	IMP dehydrogenase activity
AYC65_RS11200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AYC65_RS11200	COG0617	tRNA 3'-terminal CCA addition
AYC65_RS11205	COG3361	conserved protein (COG2071)
AYC65_RS11210	COG4771	TonB-dependent receptor
AYC65_RS11215	COG4232	protein-disulfide reductase activity
AYC65_RS11220	COG3104	oligopeptide transport
AYC65_RS11225	COG3104	oligopeptide transport
AYC65_RS11235	COG0823	Involved in the tonB-independent uptake of proteins
AYC65_RS11235	COG1506	peptidase
AYC65_RS11255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYC65_RS11260	COG2755	lipolytic protein G-D-S-L family
AYC65_RS11275	COG1446	asparaginase
AYC65_RS11290	COG1566	PFAM secretion protein HlyD family protein
AYC65_RS11300	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AYC65_RS11315	COG2223	nitrite transmembrane transporter activity
AYC65_RS11320	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
AYC65_RS11330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AYC65_RS11355	COG2017	converts alpha-aldose to the beta-anomer
AYC65_RS11360	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AYC65_RS11365	COG1085	galactose-1-phosphate uridylyltransferase
AYC65_RS11370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AYC65_RS11385	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS11390	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AYC65_RS11395	COG2271	Major facilitator Superfamily
AYC65_RS11405	COG0579	oxidoreductase
AYC65_RS11410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AYC65_RS11415	COG0739	heme binding
AYC65_RS11425	COG2264	protein methyltransferase activity
AYC65_RS11430	COG0149	triose-phosphate isomerase activity
AYC65_RS11460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AYC65_RS11465	COG1522	sequence-specific DNA binding
AYC65_RS11470	COG0697	spore germination
AYC65_RS11505	COG0358	DNA primase activity
AYC65_RS11510	COG0586	Pfam SNARE associated Golgi protein
AYC65_RS11520	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AYC65_RS11530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYC65_RS11545	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AYC65_RS11550	COG0300	oxidoreductase activity
AYC65_RS11560	COG2272	Belongs to the type-B carboxylesterase lipase family
AYC65_RS11570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AYC65_RS11595	COG2972	Histidine kinase
AYC65_RS11600	COG3279	Response regulator of the LytR AlgR family
AYC65_RS11605	COG2217	Heavy metal translocating P-type atpase
AYC65_RS11620	COG2204	response regulator
AYC65_RS11625	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AYC65_RS11635	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AYC65_RS11645	COG2205	protein histidine kinase activity
AYC65_RS11670	COG4717	serine-type aminopeptidase activity
AYC65_RS11675	COG1472	Belongs to the glycosyl hydrolase 3 family
AYC65_RS11680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AYC65_RS11685	COG0612	Peptidase, M16
AYC65_RS11690	COG1027	Aspartate ammonia-lyase
AYC65_RS11695	COG3023	N-Acetylmuramoyl-L-alanine amidase
AYC65_RS11740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AYC65_RS11785	COG0475	glutathione-regulated potassium exporter activity
AYC65_RS11790	COG3279	Response regulator of the LytR AlgR family
AYC65_RS11800	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AYC65_RS11805	COG0352	thiamine-phosphate diphosphorylase activity
AYC65_RS11810	COG0351	phosphomethylpyrimidine kinase
AYC65_RS11810	COG0352	thiamine-phosphate diphosphorylase activity
AYC65_RS11855	COG0492	ferredoxin-NADP+ reductase activity
AYC65_RS11875	COG1011	Hydrolase
AYC65_RS11910	COG1333	cytochrome c biogenesis protein
AYC65_RS11910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AYC65_RS11915	COG1674	ftsk spoiiie
AYC65_RS11940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AYC65_RS11955	COG2195	Cleaves the N-terminal amino acid of tripeptides
AYC65_RS11975	COG0492	ferredoxin-NADP+ reductase activity
AYC65_RS11985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AYC65_RS12000	COG2824	Alkylphosphonate utilization operon protein PhnA
AYC65_RS12005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AYC65_RS12005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AYC65_RS12025	COG0367	asparagine synthase
AYC65_RS12040	COG0456	acetyltransferase
AYC65_RS12045	COG0402	S-adenosylhomocysteine deaminase activity
AYC65_RS12050	COG0666	response to abiotic stimulus
AYC65_RS12060	COG0402	S-adenosylhomocysteine deaminase activity
AYC65_RS12070	COG4145	pantothenate transmembrane transporter activity
AYC65_RS12075	COG1136	(ABC) transporter
AYC65_RS12075	COG0577	efflux transmembrane transporter activity
AYC65_RS12080	COG1136	(ABC) transporter
AYC65_RS12080	COG0577	efflux transmembrane transporter activity
AYC65_RS12085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYC65_RS12110	COG3876	Protein conserved in bacteria
AYC65_RS12125	COG3118	belongs to the thioredoxin family
AYC65_RS12130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AYC65_RS12140	COG1012	belongs to the aldehyde dehydrogenase family
AYC65_RS12150	COG0006	proline dipeptidase activity
AYC65_RS12155	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AYC65_RS12160	COG5290	Psort location Cytoplasmic, score
AYC65_RS12275	COG2706	6-phosphogluconolactonase activity
AYC65_RS12290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYC65_RS12385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AYC65_RS12415	COG2274	protein secretion by the type I secretion system
AYC65_RS12420	COG1349	DNA-binding transcription factor activity
AYC65_RS12440	COG1538	Outer membrane efflux protein
AYC65_RS12460	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AYC65_RS12465	COG4654	Cytochrome c, class I
AYC65_RS12500	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AYC65_RS12505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AYC65_RS12510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AYC65_RS12515	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AYC65_RS12520	COG0156	8-amino-7-oxononanoate synthase activity
AYC65_RS12530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYC65_RS12585	COG2807	transmembrane transport
AYC65_RS12615	COG0659	secondary active sulfate transmembrane transporter activity
AYC65_RS12650	COG0038	chloride channel
AYC65_RS12745	COG1960	acyl-CoA dehydrogenase activity
AYC65_RS12755	COG3655	Transcriptional regulator
AYC65_RS12760	COG1131	(ABC) transporter
AYC65_RS12805	COG3422	double-strand break repair
AYC65_RS12815	COG4585	Histidine kinase
AYC65_RS12835	COG0561	phosphatase activity
AYC65_RS12840	COG0494	nUDIX hydrolase
AYC65_RS12850	COG0183	Belongs to the thiolase family
AYC65_RS12865	COG0183	Belongs to the thiolase family
AYC65_RS12870	COG1309	transcriptional regulator
AYC65_RS12880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYC65_RS12880	COG2169	Transcriptional regulator
AYC65_RS12905	COG2207	Transcriptional regulator
AYC65_RS12910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYC65_RS12925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYC65_RS12950	COG0038	chloride channel
AYC65_RS12955	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS12980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AYC65_RS12985	COG1053	succinate dehydrogenase
AYC65_RS13000	COG0471	metal ion transport
AYC65_RS13020	COG4716	Myosin-crossreactive antigen
AYC65_RS13025	COG1024	Enoyl-CoA hydratase
AYC65_RS13025	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYC65_RS13035	COG3279	Response regulator of the LytR AlgR family
AYC65_RS13065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AYC65_RS13065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AYC65_RS13090	COG1876	peptidase activity
AYC65_RS13095	COG3621	Patatin-like phospholipase
AYC65_RS13160	COG1063	alcohol dehydrogenase
AYC65_RS13250	COG4771	TonB-dependent receptor
AYC65_RS13285	COG0829	nickel cation binding
AYC65_RS13290	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AYC65_RS13300	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AYC65_RS13310	COG0804	urea catabolic process
AYC65_RS13315	COG0832	Belongs to the urease beta subunit family
AYC65_RS13320	COG0831	urea catabolic process
AYC65_RS13340	COG3119	arylsulfatase activity
AYC65_RS13345	COG0233	cytoplasmic translational termination
AYC65_RS13350	COG0528	UMP kinase activity
AYC65_RS13355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AYC65_RS13380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYC65_RS13395	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AYC65_RS13400	COG1253	flavin adenine dinucleotide binding
AYC65_RS13410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AYC65_RS13415	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AYC65_RS13420	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AYC65_RS13425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AYC65_RS13430	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AYC65_RS13435	COG0356	it plays a direct role in the translocation of protons across the membrane
AYC65_RS13460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AYC65_RS13465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AYC65_RS13470	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AYC65_RS13475	COG0649	NAD binding
AYC65_RS13480	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AYC65_RS13485	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AYC65_RS13495	COG1034	ATP synthesis coupled electron transport
AYC65_RS13500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AYC65_RS13505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AYC65_RS13510	COG0839	Belongs to the complex I subunit 6 family
AYC65_RS13515	COG0713	ATP synthesis coupled electron transport
AYC65_RS13520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AYC65_RS13525	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AYC65_RS13530	COG1007	ATP synthesis coupled electron transport
AYC65_RS13570	COG2936	dipeptidyl-peptidase activity
AYC65_RS13575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYC65_RS13580	COG3956	TIGRFAM MazG family protein
AYC65_RS13590	COG0242	peptide deformylase activity
AYC65_RS13595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AYC65_RS13610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYC65_RS13615	COG0284	orotidine-5'-phosphate decarboxylase activity
AYC65_RS13615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AYC65_RS13665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYC65_RS13670	COG0443	Heat shock 70 kDa protein
AYC65_RS13675	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AYC65_RS13680	COG0248	Ppx GppA phosphatase
AYC65_RS13690	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AYC65_RS13695	COG0489	protein tyrosine kinase activity
AYC65_RS13720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AYC65_RS13725	COG0708	Exodeoxyribonuclease III
AYC65_RS13750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AYC65_RS13770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYC65_RS13785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AYC65_RS13790	COG1794	racemase activity, acting on amino acids and derivatives
AYC65_RS13795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AYC65_RS13805	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AYC65_RS13835	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
AYC65_RS13840	COG1301	dicarboxylic acid transport
AYC65_RS13845	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AYC65_RS13850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AYC65_RS13880	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AYC65_RS13885	COG3119	arylsulfatase activity
AYC65_RS13895	COG1629	transport
AYC65_RS13900	COG0205	6-phosphofructokinase activity
AYC65_RS13910	COG4771	TonB-dependent receptor
AYC65_RS13915	COG0720	synthase
AYC65_RS13920	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYC65_RS13950	COG2224	Isocitrate lyase
AYC65_RS13955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AYC65_RS13960	COG1396	sequence-specific DNA binding
AYC65_RS13970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AYC65_RS13995	COG1160	GTP binding
AYC65_RS14015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AYC65_RS14025	COG1704	LemA family
AYC65_RS14035	COG0436	Aminotransferase
AYC65_RS14045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AYC65_RS14050	COG0113	porphobilinogen synthase activity
AYC65_RS14065	COG1522	sequence-specific DNA binding
AYC65_RS14075	COG0336	Belongs to the RNA methyltransferase TrmD family
AYC65_RS14095	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
AYC65_RS14100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AYC65_RS14105	COG0488	(ABC) transporter
AYC65_RS14110	COG0813	purine-nucleoside phosphorylase activity
AYC65_RS14120	COG0673	inositol 2-dehydrogenase activity
AYC65_RS14125	COG4206	TonB-dependent receptor
AYC65_RS14135	COG3264	Mechanosensitive ion channel
AYC65_RS14135	COG1196	nuclear chromosome segregation
AYC65_RS14140	COG0045	succinate-CoA ligase (ADP-forming) activity
AYC65_RS14160	COG0488	(ABC) transporter
AYC65_RS14185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYC65_RS14315	COG3023	N-Acetylmuramoyl-L-alanine amidase
AYC65_RS14345	COG4383	Mu-like prophage protein gp29
AYC65_RS14500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AYC65_RS14530	COG3321	synthase
AYC65_RS14530	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS14530	COG0604	alcohol dehydrogenase
AYC65_RS14545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYC65_RS14570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AYC65_RS14590	COG0018	arginyl-trna synthetase
AYC65_RS14600	COG1629	transport
AYC65_RS14610	COG4771	TonB-dependent receptor
AYC65_RS14620	COG4771	TonB-dependent receptor
AYC65_RS14630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AYC65_RS14640	COG0706	membrane insertase activity
AYC65_RS14645	COG0504	CTP synthase activity
AYC65_RS14650	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AYC65_RS14675	COG4221	oxidoreductase activity
AYC65_RS14705	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AYC65_RS14710	COG0459	protein refolding
AYC65_RS14780	COG0494	nUDIX hydrolase
AYC65_RS14815	COG2267	carboxylic ester hydrolase activity
AYC65_RS14840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AYC65_RS14890	COG4771	TonB-dependent receptor
AYC65_RS14895	COG0702	epimerase
AYC65_RS14900	COG0584	glycerophosphoryl diester phosphodiesterase
AYC65_RS14905	COG0584	glycerophosphoryl diester phosphodiesterase
AYC65_RS14915	COG0339	signal peptide processing
AYC65_RS14935	COG4628	conserved protein (DUF2132)
AYC65_RS14940	COG1047	Peptidyl-prolyl cis-trans
AYC65_RS14950	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AYC65_RS14960	COG0259	pyridoxamine-phosphate oxidase activity
AYC65_RS14965	COG1678	Uncharacterized ACR, COG1678
AYC65_RS14985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYC65_RS15000	COG3158	transport of potassium into the cell
AYC65_RS15005	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYC65_RS15005	COG0022	dehydrogenase e1 component
AYC65_RS15015	COG1183	phosphatidylcholine synthase activity
AYC65_RS15020	COG2176	DNA-directed DNA polymerase activity
AYC65_RS15095	COG1733	regulation of RNA biosynthetic process
AYC65_RS15100	COG0544	peptidyl-prolyl cis-trans isomerase activity
AYC65_RS15120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AYC65_RS15120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AYC65_RS15130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AYC65_RS15135	COG0514	ATP-dependent DNA helicase (RecQ)
AYC65_RS15155	COG0616	signal peptide processing
AYC65_RS15160	COG2261	transglycosylase associated protein
AYC65_RS15165	COG0552	protein localization to endoplasmic reticulum
AYC65_RS15170	COG0251	oxidation-reduction process
AYC65_RS15180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AYC65_RS15185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AYC65_RS15205	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AYC65_RS15210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYC65_RS15215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AYC65_RS15220	COG2226	methyltransferase
AYC65_RS15235	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AYC65_RS15260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYC65_RS15295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYC65_RS15310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AYC65_RS15330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AYC65_RS15360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AYC65_RS15365	COG0194	GDP metabolic process
AYC65_RS15370	COG4106	trans-aconitate 2-methyltransferase activity
AYC65_RS15375	COG1561	YicC-like family, N-terminal region
AYC65_RS15385	COG1663	tetraacyldisaccharide 4'-kinase activity
AYC65_RS15395	COG0222	ribosome binding
AYC65_RS15400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AYC65_RS15405	COG0081	regulation of translation
AYC65_RS15410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AYC65_RS15420	COG1733	regulation of RNA biosynthetic process
AYC65_RS15425	COG3047	cAMP biosynthetic process
AYC65_RS15445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AYC65_RS15480	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AYC65_RS15485	COG1074	ATP-dependent DNA helicase activity
AYC65_RS15500	COG0322	excinuclease ABC activity
AYC65_RS15510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AYC65_RS15520	COG0861	Integral membrane protein TerC family
AYC65_RS15525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYC65_RS15530	COG2986	histidine ammonia-lyase
AYC65_RS15535	COG1528	Iron-storage protein
AYC65_RS15555	COG1640	4-alpha-glucanotransferase
AYC65_RS15560	COG0215	cysteine-tRNA ligase activity
AYC65_RS15565	COG0302	gtp cyclohydrolase
AYC65_RS15570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYC65_RS15575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AYC65_RS15580	COG0571	ribonuclease III activity
AYC65_RS15595	COG1115	amino acid carrier protein
AYC65_RS15600	COG1012	belongs to the aldehyde dehydrogenase family
AYC65_RS15605	COG0010	Belongs to the arginase family
AYC65_RS15615	COG2255	four-way junction helicase activity
AYC65_RS15625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYC65_RS15630	COG0237	dephospho-CoA kinase activity
AYC65_RS15645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AYC65_RS15660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AYC65_RS15665	COG1053	succinate dehydrogenase
AYC65_RS15675	COG2333	competence protein COMEC
AYC65_RS15675	COG0658	competence protein
AYC65_RS15680	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYC65_RS15705	COG3655	Transcriptional regulator
AYC65_RS15710	COG2207	Transcriptional regulator
AYC65_RS15715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AYC65_RS15720	COG0167	dihydroorotate dehydrogenase activity
AYC65_RS15735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AYC65_RS15740	COG1132	(ABC) transporter
AYC65_RS15755	COG1629	transport
AYC65_RS15755	COG4206	TonB-dependent receptor
AYC65_RS15760	COG2205	protein histidine kinase activity
AYC65_RS15765	COG0745	RESPONSE REGULATOR receiver
AYC65_RS15775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AYC65_RS15815	COG0495	leucyl-tRNA aminoacylation
AYC65_RS15825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AYC65_RS15825	COG1519	Transferase
AYC65_RS15835	COG0791	NLP P60 protein
AYC65_RS15845	COG0037	tRNA processing
AYC65_RS15855	COG2267	carboxylic ester hydrolase activity
AYC65_RS15870	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AYC65_RS15875	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AYC65_RS15880	COG2884	Cell division ATP-binding protein ftsE
AYC65_RS15885	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AYC65_RS15890	COG5000	phosphorelay sensor kinase activity
AYC65_RS15895	COG0307	riboflavin synthase, alpha
AYC65_RS15900	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AYC65_RS15910	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AYC65_RS15915	COG0511	ligase activity, forming carbon-carbon bonds
AYC65_RS15920	COG0439	Biotin carboxylase
AYC65_RS15925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYC65_RS15965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYC65_RS15970	COG0825	malonyl-CoA metabolic process
AYC65_RS15980	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AYC65_RS15985	COG0516	GMP reductase activity
AYC65_RS15985	COG0517	IMP dehydrogenase activity
AYC65_RS15990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AYC65_RS16000	COG0052	Belongs to the universal ribosomal protein uS2 family
AYC65_RS16005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AYC65_RS16010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AYC65_RS16030	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AYC65_RS16030	COG1703	isobutyryl-CoA mutase activity
AYC65_RS16030	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AYC65_RS16080	COG0612	Peptidase, M16
AYC65_RS16085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AYC65_RS16105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AYC65_RS16115	COG0300	oxidoreductase activity
AYC65_RS16135	COG0254	rRNA binding
AYC65_RS16150	COG1595	DNA-templated transcription, initiation
AYC65_RS16175	COG1609	Transcriptional regulator
AYC65_RS16180	COG1904	glucuronate isomerase
AYC65_RS16185	COG1312	Catalyzes the dehydration of D-mannonate
AYC65_RS16190	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS16230	COG2949	membrane
AYC65_RS16235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AYC65_RS16245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AYC65_RS16260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AYC65_RS16280	COG1091	dTDP-4-dehydrorhamnose reductase activity
AYC65_RS16290	COG0180	Tryptophanyl-tRNA synthetase
AYC65_RS16295	COG1609	Transcriptional regulator
AYC65_RS16300	COG0246	Mannitol dehydrogenase
AYC65_RS16305	COG0738	Major facilitator superfamily
AYC65_RS16320	COG1011	Hydrolase
AYC65_RS16345	COG1132	(ABC) transporter
AYC65_RS16355	COG0688	phosphatidylethanolamine metabolic process
AYC65_RS16360	COG4589	Belongs to the CDS family
AYC65_RS16370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYC65_RS16375	COG0799	negative regulation of ribosome biogenesis
AYC65_RS16390	COG0343	queuine tRNA-ribosyltransferase activity
AYC65_RS16400	COG0463	Glycosyl transferase, family 2
AYC65_RS16415	COG1770	oligopeptidase
AYC65_RS16460	COG0437	4 iron, 4 sulfur cluster binding
AYC65_RS16500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AYC65_RS16520	COG1368	sulfuric ester hydrolase activity
AYC65_RS16525	COG2321	neutral zinc metallopeptidase
AYC65_RS16530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AYC65_RS16535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYC65_RS16540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AYC65_RS16560	COG2081	HI0933 family
AYC65_RS16570	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AYC65_RS16580	COG2195	Cleaves the N-terminal amino acid of tripeptides
AYC65_RS16585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AYC65_RS16595	COG2151	metal-sulfur cluster biosynthetic enzyme
AYC65_RS16615	COG0662	Cupin 2, conserved barrel domain protein
AYC65_RS16615	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AYC65_RS16745	COG4383	Mu-like prophage protein gp29
AYC65_RS16840	COG0606	chelatase, subunit chli
AYC65_RS16890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AYC65_RS16915	COG0019	diaminopimelate decarboxylase activity
AYC65_RS16920	COG2176	DNA-directed DNA polymerase activity
AYC65_RS16925	COG0433	COG0433 Predicted ATPase
AYC65_RS16940	COG3118	belongs to the thioredoxin family
AYC65_RS16945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AYC65_RS16965	COG0811	peptide transport
AYC65_RS17000	COG2166	iron-sulfur cluster assembly
AYC65_RS17010	COG0542	response to heat
AYC65_RS17035	COG1610	YqeY-like protein
AYC65_RS17040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AYC65_RS17055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AYC65_RS17060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AYC65_RS17070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AYC65_RS17075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AYC65_RS17085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AYC65_RS17090	COG0768	penicillin binding
AYC65_RS17100	COG0275	rRNA processing
AYC65_RS17105	COG2001	Belongs to the MraZ family
AYC65_RS17115	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AYC65_RS17120	COG2153	protein acetylation
AYC65_RS17135	COG4206	TonB-dependent receptor
AYC65_RS17160	COG0653	protein targeting
AYC65_RS17170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYC65_RS17190	COG1505	serine-type exopeptidase activity
AYC65_RS17210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AYC65_RS17215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AYC65_RS17220	COG1368	sulfuric ester hydrolase activity
AYC65_RS17230	COG2304	oxidoreductase activity
AYC65_RS17260	COG3033	Beta-eliminating lyase
AYC65_RS17275	COG0556	nucleotide-excision repair
AYC65_RS17300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AYC65_RS17310	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AYC65_RS17330	COG0363	glucosamine-6-phosphate deaminase activity
AYC65_RS17350	COG3279	Response regulator of the LytR AlgR family
AYC65_RS17380	COG2032	superoxide dismutase activity
AYC65_RS17425	COG3264	Mechanosensitive ion channel
AYC65_RS17425	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AYC65_RS17435	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AYC65_RS17455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AYC65_RS17475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AYC65_RS17490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AYC65_RS17500	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AYC65_RS17505	COG0445	tRNA wobble uridine modification
AYC65_RS17515	COG0126	phosphoglycerate kinase activity
AYC65_RS17520	COG0698	ribose 5-phosphate isomerase
AYC65_RS17525	COG0557	exoribonuclease II activity
AYC65_RS17535	COG1619	proteins homologs of microcin C7 resistance protein MccF
AYC65_RS17540	COG0792	nuclease activity
AYC65_RS17545	COG4221	oxidoreductase activity
AYC65_RS17550	COG1214	PFAM Peptidase M22, glycoprotease
AYC65_RS17555	COG0424	maF-like protein
AYC65_RS17560	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AYC65_RS17570	COG1733	regulation of RNA biosynthetic process
AYC65_RS17575	COG2814	Major facilitator Superfamily
AYC65_RS17580	COG1595	DNA-templated transcription, initiation
AYC65_RS17595	COG0481	GTPase activity
AYC65_RS17640	COG1397	ADP-ribosylglycohydrolase
AYC65_RS17645	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AYC65_RS17710	COG0358	DNA primase activity
AYC65_RS17745	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYC65_RS17750	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYC65_RS17765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYC65_RS17780	COG2217	Heavy metal translocating P-type atpase
AYC65_RS17800	COG1830	Aldolase
AYC65_RS17810	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AYC65_RS17825	COG2217	Heavy metal translocating P-type atpase
AYC65_RS17865	COG0791	NLP P60 protein
AYC65_RS17870	COG0772	Belongs to the SEDS family
AYC65_RS17885	COG1792	Involved in formation and maintenance of cell shape
AYC65_RS17950	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AYC65_RS17970	COG0482	sulfurtransferase activity
AYC65_RS17980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AYC65_RS17990	COG0181	hydroxymethylbilane synthase activity
AYC65_RS17995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AYC65_RS18010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AYC65_RS18015	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AYC65_RS18040	COG2733	membrane
AYC65_RS18045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AYC65_RS18065	COG0316	Belongs to the HesB IscA family
AYC65_RS18070	COG0719	Fe-S assembly protein
AYC65_RS18075	COG0396	ATPase activity
AYC65_RS18080	COG0719	Fe-S assembly protein
AYC65_RS18085	COG0393	Putative heavy-metal-binding
AYC65_RS18095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AYC65_RS18100	COG0025	NhaP-type Na H and K H
AYC65_RS18120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AYC65_RS18125	COG0423	glycine-tRNA ligase activity
AYC65_RS18140	COG0700	Nucleoside recognition
AYC65_RS18165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AYC65_RS18175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AYC65_RS18195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AYC65_RS18200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYC65_RS18215	COG1774	PSP1 C-terminal conserved region
AYC65_RS18225	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AYC65_RS18230	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AYC65_RS18245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AYC65_RS18250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AYC65_RS18260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AYC65_RS18265	COG0387	Pfam Sodium calcium exchanger
AYC65_RS18285	COG3591	Belongs to the peptidase S1B family
AYC65_RS18295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AYC65_RS18305	COG3829	transcription factor binding
AYC65_RS18330	COG0594	ribonuclease P activity
AYC65_RS18335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AYC65_RS18340	COG0084	hydrolase, TatD family'
AYC65_RS18345	COG1309	transcriptional regulator
AYC65_RS18380	COG0497	DNA recombination
AYC65_RS18395	COG4152	abc transporter atp-binding protein
AYC65_RS18410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AYC65_RS18415	COG1309	transcriptional regulator
AYC65_RS18420	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AYC65_RS18420	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AYC65_RS18430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AYC65_RS18435	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AYC65_RS18435	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AYC65_RS18450	COG1690	Belongs to the RtcB family
AYC65_RS18460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AYC65_RS18470	COG1703	isobutyryl-CoA mutase activity
AYC65_RS18495	COG1127	ABC transporter
AYC65_RS18500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AYC65_RS18505	COG0602	queuosine metabolic process
AYC65_RS18510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AYC65_RS18515	COG0166	Belongs to the GPI family
AYC65_RS18535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AYC65_RS18540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AYC65_RS18545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AYC65_RS18550	COG2181	nitrate reductase activity
AYC65_RS18550	COG0247	lactate metabolic process
AYC65_RS18555	COG2181	nitrate reductase activity
AYC65_RS18555	COG0247	lactate metabolic process
AYC65_RS18570	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AYC65_RS18615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYC65_RS18620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AYC65_RS18625	COG0564	pseudouridine synthase activity
AYC65_RS18635	COG0137	argininosuccinate synthase activity
AYC65_RS18640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AYC65_RS18655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AYC65_RS18665	COG0165	Argininosuccinate lyase
AYC65_RS18670	COG1522	sequence-specific DNA binding
AYC65_RS18695	COG3275	phosphorelay sensor kinase activity
AYC65_RS18700	COG3279	Response regulator of the LytR AlgR family
AYC65_RS18760	COG1770	oligopeptidase
AYC65_RS18775	COG1607	acyl-coa hydrolase
AYC65_RS18780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AYC65_RS18785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYC65_RS18820	COG1024	Enoyl-CoA hydratase
AYC65_RS18835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AYC65_RS18855	COG1629	transport
AYC65_RS18855	COG4206	TonB-dependent receptor
AYC65_RS18890	COG1611	Belongs to the LOG family
AYC65_RS18895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AYC65_RS18915	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AYC65_RS18920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AYC65_RS18960	COG0328	RNA-DNA hybrid ribonuclease activity
AYC65_RS18965	COG0305	Participates in initiation and elongation during chromosome replication
AYC65_RS18985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AYC65_RS18990	COG0193	aminoacyl-tRNA hydrolase activity
AYC65_RS18995	COG0659	secondary active sulfate transmembrane transporter activity
AYC65_RS19005	COG0288	reversible hydration of carbon dioxide
AYC65_RS19010	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AYC65_RS19015	COG1082	Xylose isomerase domain protein TIM barrel
AYC65_RS19020	COG0779	Required for maturation of 30S ribosomal subunits
AYC65_RS19025	COG0195	Participates in both transcription termination and antitermination
AYC65_RS19030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AYC65_RS19035	COG4771	TonB-dependent receptor
AYC65_RS19045	COG1629	transport
AYC65_RS19060	COG1629	transport
AYC65_RS19085	COG1629	transport
AYC65_RS19100	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AYC65_RS19105	COG1705	Flagellar rod assembly protein muramidase FlgJ
AYC65_RS19105	COG1388	LysM domain
AYC65_RS19120	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AYC65_RS19125	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AYC65_RS19130	COG4771	TonB-dependent receptor
AYC65_RS19140	COG1193	negative regulation of DNA recombination
AYC65_RS19145	COG2814	Major facilitator Superfamily
AYC65_RS19155	COG1940	carbohydrate kinase activity
AYC65_RS19195	COG0268	Binds directly to 16S ribosomal RNA
AYC65_RS19215	COG0251	oxidation-reduction process
AYC65_RS19225	COG4771	TonB-dependent receptor
AYC65_RS19235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYC65_RS19240	COG1054	Belongs to the UPF0176 family
AYC65_RS19265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYC65_RS19285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AYC65_RS19290	COG0783	Belongs to the Dps family
AYC65_RS19300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AYC65_RS19305	COG0049	tRNA binding
AYC65_RS19310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AYC65_RS19315	COG0051	transcription antitermination factor activity, RNA binding
AYC65_RS19360	COG3250	beta-galactosidase activity
AYC65_RS19405	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AYC65_RS19410	COG0088	Forms part of the polypeptide exit tunnel
AYC65_RS19415	COG0089	rRNA binding
AYC65_RS19420	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AYC65_RS19425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AYC65_RS19430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AYC65_RS19435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AYC65_RS19440	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AYC65_RS19445	COG0255	Belongs to the universal ribosomal protein uL29 family
AYC65_RS19450	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AYC65_RS19455	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AYC65_RS19460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AYC65_RS19465	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AYC65_RS19470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AYC65_RS19475	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AYC65_RS19480	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AYC65_RS19485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AYC65_RS19490	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AYC65_RS19495	COG1841	ribosomal large subunit assembly
AYC65_RS19500	COG0200	Binds to the 23S rRNA
AYC65_RS19505	COG0201	protein transport
AYC65_RS19510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AYC65_RS19515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AYC65_RS19520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AYC65_RS19525	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AYC65_RS19530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AYC65_RS19535	COG0202	RNA polymerase activity
AYC65_RS19540	COG0203	ribosomal protein L17
AYC65_RS19550	COG0148	phosphopyruvate hydratase activity
AYC65_RS19570	COG1834	amidinotransferase
AYC65_RS19575	COG2873	o-acetylhomoserine
AYC65_RS19595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AYC65_RS19600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AYC65_RS19600	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AYC65_RS19605	COG0501	Belongs to the peptidase M48B family
AYC65_RS19610	COG0488	(ABC) transporter
AYC65_RS19615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AYC65_RS19625	COG0217	transcriptional regulatory protein
AYC65_RS19660	COG0714	Associated with various cellular activities
AYC65_RS19695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AYC65_RS19720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYC65_RS19725	COG0460	homoserine dehydrogenase
AYC65_RS19725	COG0527	aspartate kinase activity
AYC65_RS19740	COG1410	methionine synthase
AYC65_RS19740	COG0646	methionine synthase
AYC65_RS19760	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AYC65_RS19780	COG0247	lactate metabolic process
AYC65_RS19785	COG1139	Iron-sulfur cluster binding protein
AYC65_RS19790	COG1556	Lactate utilization protein
AYC65_RS19795	COG0738	Major facilitator superfamily
AYC65_RS19800	COG2721	sulfolactate sulfo-lyase activity
AYC65_RS19805	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS19810	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYC65_RS19815	COG3254	rhamnose metabolic process
AYC65_RS19825	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS19840	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AYC65_RS19860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AYC65_RS19885	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AYC65_RS19890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYC65_RS19895	COG1396	sequence-specific DNA binding
AYC65_RS19965	COG0456	acetyltransferase
AYC65_RS19970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AYC65_RS19975	COG0366	Alpha amylase catalytic
AYC65_RS20020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AYC65_RS20025	COG0085	RNA polymerase activity
AYC65_RS20030	COG3250	beta-galactosidase activity
AYC65_RS20075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYC65_RS20105	COG2207	Transcriptional regulator
AYC65_RS20110	COG2223	nitrite transmembrane transporter activity
AYC65_RS20265	COG1858	cytochrome C peroxidase
AYC65_RS20340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AYC65_RS20345	COG0438	transferase activity, transferring glycosyl groups
AYC65_RS20350	COG1472	Belongs to the glycosyl hydrolase 3 family
AYC65_RS20355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AYC65_RS20370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AYC65_RS20385	COG0756	dUTP diphosphatase activity
AYC65_RS20395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AYC65_RS20400	COG3537	Alpha-1,2-mannosidase
AYC65_RS20405	COG1028	Short-chain dehydrogenase reductase Sdr
AYC65_RS20440	COG0542	response to heat
AYC65_RS20445	COG1121	(ABC) transporter
AYC65_RS20460	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AYC65_RS20465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYC65_RS20475	COG3396	Phenylacetate-CoA oxygenase
AYC65_RS20480	COG3460	Phenylacetate-CoA oxygenase
AYC65_RS20490	COG1073	alpha beta
AYC65_RS20495	COG2151	metal-sulfur cluster biosynthetic enzyme
AYC65_RS20500	COG1024	Enoyl-CoA hydratase
AYC65_RS20505	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYC65_RS20515	COG0183	Belongs to the thiolase family
AYC65_RS20530	COG1012	belongs to the aldehyde dehydrogenase family
AYC65_RS20530	COG2030	dehydratase
AYC65_RS20570	COG1408	metallophosphoesterase
AYC65_RS20595	COG1490	D-aminoacyl-tRNA deacylase activity
AYC65_RS20600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AYC65_RS20610	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AYC65_RS20635	COG0582	viral genome integration into host DNA