locus-tag class description HRR29_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HRR29_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HRR29_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRR29_RS00035 ENOG410667J hydrolase HRR29_RS00040 ENOG4105D99 atp gtp-binding protein HRR29_RS00045 ENOG4105R2A (LipO)protein HRR29_RS00055 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) HRR29_RS00060 ENOG4105D0C transport protein HRR29_RS00065 ENOG4105FDP GntR family transcriptional regulator HRR29_RS00070 ENOG4105CI1 PTS System HRR29_RS00075 ENOG4105F8D glycoside hydrolase family 4 HRR29_RS00080 ENOG4105VG5 Membrane HRR29_RS00085 ENOG4105JP4 Inner membrane protein yidG HRR29_RS00100 ENOG4105W8I Transcriptional regulator HRR29_RS00110 ENOG4105E5M Multidrug resistance protein D HRR29_RS00135 ENOG4108WC9 type VI secretion system effector, hcp1 family HRR29_RS00145 ENOG4105C7K acetolactate synthase HRR29_RS00150 ENOG4105M71 acetolactate synthase 1 regulatory subunit HRR29_RS00155 ENOG4108KX4 response regulator HRR29_RS00160 ENOG4105BZU Histidine kinase HRR29_RS00165 ENOG4105CXY transporter HRR29_RS00170 ENOG4105CXY transporter HRR29_RS00175 ENOG4108SAJ Protein of unknown function (DUF1198) HRR29_RS00185 ENOG4108UZ3 Transporter HRR29_RS00190 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HRR29_RS00195 ENOG4105VCP PTS System HRR29_RS00200 ENOG4105CS2 ec 3.2.1.21 HRR29_RS00205 ENOG4105CK1 PTS System HRR29_RS00215 ENOG4105ETE Transcriptional regulator (LacI family HRR29_RS00225 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HRR29_RS00230 ENOG4105BZS acriflavin resistance protein HRR29_RS00235 ENOG4105C1P efflux transporter, rnd family, mfp subunit HRR29_RS00240 ENOG41067SE Tetr family transcriptional regulator HRR29_RS00245 ENOG4105VEV -acetyltransferase HRR29_RS00250 ENOG4105D01 (LipO)protein HRR29_RS00255 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HRR29_RS00265 ENOG4105D5K Hemolysin activator protein HRR29_RS00280 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HRR29_RS00285 ENOG4107SEY Conserved Protein HRR29_RS00295 ENOG4108XDN Transcriptional regulator HRR29_RS00310 ENOG4108SQA Fimbrial HRR29_RS00315 ENOG4105CW0 outer membrane usher protein HRR29_RS00320 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HRR29_RS00345 ENOG4105ECQ AraC Family Transcriptional Regulator HRR29_RS00355 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HRR29_RS00375 ENOG4105CT4 transporter HRR29_RS00380 ENOG4105CJQ hydrolase, family 31 HRR29_RS00385 ENOG4105JV1 AsmA family HRR29_RS00390 ENOG4105C2W permease HRR29_RS00395 ENOG4105D6U Sodium Glutamate Symporter HRR29_RS00400 ENOG4105CB5 ATP-dependent DNA helicase recG HRR29_RS00405 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HRR29_RS00410 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HRR29_RS00425 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HRR29_RS00430 ENOG4105EN6 Membrane HRR29_RS00435 ENOG4105DSJ YicC domain protein HRR29_RS00440 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HRR29_RS00445 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HRR29_RS00450 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HRR29_RS00455 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HRR29_RS00460 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HRR29_RS00465 ENOG4105W5Q DNA repair protein (RadC HRR29_RS00470 ENOG4105KDC 50s ribosomal protein l28 HRR29_RS00475 ENOG4105W0E 50S ribosomal protein L33 HRR29_RS00480 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HRR29_RS00485 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HRR29_RS00490 ENOG4106WTF Glycosyl transferase, family 2 HRR29_RS00495 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HRR29_RS00500 ENOG4105K64 Glycosyl transferase, family 2 HRR29_RS00505 ENOG4105CPK Glycosyl transferase (Group 1 HRR29_RS00515 ENOG4105DKP glycosyl transferase, family 9 HRR29_RS00540 ENOG4105D16 lipopolysaccharide heptosyltransferase i HRR29_RS00545 ENOG4105XA0 heptosyltransferase ii HRR29_RS00550 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HRR29_RS00555 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HRR29_RS00560 ENOG4105CPQ Dehydrogenase HRR29_RS00570 ENOG4107TAE Glycosyl transferase (Group 1 HRR29_RS00580 ENOG4105PXI polysaccharide deacetylase HRR29_RS00585 ENOG41063SB peptidase HRR29_RS00590 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HRR29_RS00595 ENOG4107YZP Rhodanese domain protein HRR29_RS00600 ENOG4105VW4 glutaredoxin 3 HRR29_RS00605 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HRR29_RS00610 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HRR29_RS00615 ENOG4105D7W serine acetyltransferase HRR29_RS00620 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HRR29_RS00625 ENOG4105D2S major facilitator superfamily HRR29_RS00630 ENOG4105DMF Dehydrogenase HRR29_RS00635 ENOG41073TP transcriptional regulator HRR29_RS00640 ENOG4105DAA L-lactate HRR29_RS00645 ENOG4108YYI Protein of unknown function (DUF2810) HRR29_RS00650 ENOG4105E61 Mannitol repressor protein HRR29_RS00660 ENOG4105CTS PTS system mannitol-specific HRR29_RS00665 ENOG4105FP6 Protein of unknown function (DUF3302) HRR29_RS00670 ENOG4105EFX secretion protein, HlyD family HRR29_RS00675 ENOG4108U78 Glutathione S-transferase HRR29_RS00685 ENOG4105EM7 Selenocysteine-specific translation elongation factor HRR29_RS00690 ENOG4105C26 Dehydrogenase HRR29_RS00695 ENOG4108Q2M Transcriptional regulator HRR29_RS00700 ENOG4105GNX MltA-interacting MipA family protein HRR29_RS00715 ENOG4108XIB electron transport protein ysaA HRR29_RS00730 ENOG4105JKW Valine--pyruvate aminotransferase HRR29_RS00735 ENOG4107T9C Alpha amylase catalytic region HRR29_RS00740 ENOG4108UR8 BAX protein HRR29_RS00745 ENOG4105T16 Transcriptional regulator (AraC family) HRR29_RS00750 ENOG4108HWW ABC transporter HRR29_RS00760 ENOG4105DFW ABC transporter HRR29_RS00765 ENOG4105C93 Xylose Isomerase HRR29_RS00770 ENOG4105CMG Carbohydrate kinase HRR29_RS00775 ENOG4108RWI nicotinamidase HRR29_RS00785 ENOG4105MEV Acyl-transferase HRR29_RS00790 ENOG4105RGS lipoprotein ysaB HRR29_RS00795 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit HRR29_RS00800 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HRR29_RS00810 ENOG4105C5H ABC transporter HRR29_RS00815 ENOG4105MVF Transcriptional regulator HRR29_RS00820 ENOG4106JH6 (LipO)protein HRR29_RS00830 ENOG4105C5I Dehydrogenase HRR29_RS00840 ENOG4105D7K pfkb domain protein HRR29_RS00850 ENOG4108M60 Transcriptional regulator HRR29_RS00855 ENOG4108ZG0 Ompa motb domain protein HRR29_RS00860 ENOG4107QY8 reductase HRR29_RS00865 ENOG4105HNP -acetyltransferase HRR29_RS00870 ENOG4108R3E Dna-3-methyladenine glycosylase i HRR29_RS00875 ENOG4105EAX Putative lipase HRR29_RS00880 ENOG4105FCD Major Facilitator HRR29_RS00885 ENOG4105DIJ Phosphoethanolamine transferase HRR29_RS00895 ENOG4105DEF Extracellular solute-binding protein, family 5 HRR29_RS00900 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRR29_RS00905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRR29_RS00910 ENOG4105C3U ABC transporter HRR29_RS00915 ENOG4108JQ7 (ABC) transporter HRR29_RS00920 ENOG4105CS9 pantothenic acid kinase HRR29_RS00945 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HRR29_RS00950 ENOG4105PM1 preprotein translocase subunit SecE HRR29_RS00955 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HRR29_RS00970 ENOG4108VZM 50s ribosomal protein L10 HRR29_RS00980 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HRR29_RS00985 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HRR29_RS01000 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HRR29_RS01005 ENOG4105D41 biosynthesis protein thiH HRR29_RS01010 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HRR29_RS01015 ENOG4105WHD thiamine biosynthesis protein ThiS HRR29_RS01020 ENOG4105D06 uba thif-type nad fad binding protein HRR29_RS01030 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HRR29_RS01035 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HRR29_RS01045 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HRR29_RS01055 ENOG4105R2J Conserved Protein HRR29_RS01060 ENOG4105K70 DNA-binding protein HRR29_RS01065 ENOG4108T8B Protein of unknown function (DUF1481) HRR29_RS01070 ENOG4105C12 Phosphoribosylglycinamide synthetase HRR29_RS01075 ENOG4105DC1 bifunctional purine biosynthesis protein purh HRR29_RS01100 ENOG4105CVG Homoserine O-transsuccinylase HRR29_RS01105 ENOG4107QP3 malate synthase g HRR29_RS01110 ENOG4108I9X Isocitrate lyase HRR29_RS01115 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HRR29_RS01120 ENOG41069M3 Transcriptional regulator HRR29_RS01125 ENOG4105C3R Methionine synthase HRR29_RS01130 ENOG4105EAM Na Pi-cotransporter HRR29_RS01135 ENOG4105YES addiction module antidote protein HRR29_RS01140 ENOG4105VUH addiction module killer protein HRR29_RS01145 ENOG4105FE9 pseudouridine synthase HRR29_RS01150 ENOG4108ZR5 Conserved Protein HRR29_RS01155 ENOG4105C09 Bile acid HRR29_RS01160 ENOG4105CFH Aspartokinase HRR29_RS01175 ENOG4108MDC (LipO)protein HRR29_RS01180 ENOG4108Q9C Periplasmic Protein HRR29_RS01185 ENOG4105E3R (LipO)protein HRR29_RS01190 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HRR29_RS01195 ENOG4105EG2 ABC transporter, permease HRR29_RS01200 ENOG4105D56 permease protein HRR29_RS01205 ENOG4107FKK extracellular solute-binding protein family 1 HRR29_RS01210 ENOG4108IJ9 (ABC) transporter HRR29_RS01215 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HRR29_RS01220 ENOG4107W52 maltose operon periplasmic protein HRR29_RS01225 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HRR29_RS01230 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HRR29_RS01240 ENOG4107FS9 Membrane HRR29_RS01250 ENOG4105MG3 Membrane HRR29_RS01255 ENOG4106H78 methyltransferase HRR29_RS01260 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HRR29_RS01265 ENOG4105CAK Cell division ATP-binding protein ftsE HRR29_RS01270 ENOG4105CRP Part of the ABC transporter FtsEX involved in HRR29_RS01275 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRR29_RS01280 ENOG4108JPW Aminotransferase HRR29_RS01290 ENOG4105U59 -acetyltransferase HRR29_RS01295 ENOG4105CP9 extracellular ligand-binding receptor HRR29_RS01300 ENOG4105C32 Amino acid ABC transporter (Permease) HRR29_RS01305 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HRR29_RS01310 ENOG4105C0Z ABC transporter HRR29_RS01315 ENOG4108IV0 ABC, transporter HRR29_RS01320 ENOG4105BZ7 extracellular solute-binding protein family 1 HRR29_RS01325 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HRR29_RS01340 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HRR29_RS01345 ENOG4105WC8 Conserved Protein HRR29_RS01350 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HRR29_RS01355 ENOG4105WCN acetyltransferase HRR29_RS01360 ENOG4105D9R oxidoreductase HRR29_RS01365 ENOG4105C2I pirin domain protein HRR29_RS01370 ENOG4105DIQ Transcriptional regulator HRR29_RS01375 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HRR29_RS01380 ENOG4105C6Z Gluconate HRR29_RS01385 ENOG4105E55 glycerol-3-phosphate acyltransferase HRR29_RS01390 ENOG41080IJ Diacylglycerol kinase HRR29_RS01395 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HRR29_RS01400 ENOG4107R73 Mate efflux family protein HRR29_RS01405 ENOG4105VDW Csbd family HRR29_RS01410 ENOG4105MYN Zinc uptake regulation protein HRR29_RS01425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HRR29_RS01430 ENOG4105P4Z Phage shock protein G HRR29_RS01435 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HRR29_RS01440 ENOG4105CDU Replicative dna helicase HRR29_RS01445 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HRR29_RS01455 ENOG4106S2D Transcriptional regulator HRR29_RS01475 ENOG4105KUS lysozyme HRR29_RS01490 ENOG4105CGF Aromatic amino acid aminotransferase HRR29_RS01495 ENOG4105F0S class B acid phosphatase HRR29_RS01500 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HRR29_RS01505 ENOG4105MSB protein, conserved in bacteria HRR29_RS01510 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HRR29_RS01515 ENOG4108UUM single-stranded DNA-binding protein HRR29_RS01520 ENOG4105PMV Membrane HRR29_RS01525 ENOG4108M8H domain protein HRR29_RS01530 ENOG4108W3Q Transcriptional regulator HRR29_RS01535 ENOG4108Z4X TRANSCRIPTIONal HRR29_RS01540 ENOG4108RXX maleylacetoacetate isomerase HRR29_RS01545 ENOG4105C7N Xanthine uracil vitamin C permease HRR29_RS01550 ENOG4105EEQ Na H antiporter HRR29_RS01555 ENOG4105CMU LysR family (Transcriptional regulator HRR29_RS01560 ENOG4105VAW lrga family HRR29_RS01565 ENOG41067MG lrgb family HRR29_RS01570 ENOG4107QN1 sodium solute HRR29_RS01575 ENOG41062QD Membrane HRR29_RS01580 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HRR29_RS01585 ENOG4105CK2 sodium dicarboxylate symporter HRR29_RS01590 ENOG41082ND Uncharacterized protein yjcO HRR29_RS01595 ENOG41074AV Hok/gef family HRR29_RS01620 ENOG4105D2N Aldolase HRR29_RS01630 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HRR29_RS01635 ENOG4105CNN ABC, transporter HRR29_RS01640 ENOG4105C2J ABC transporter HRR29_RS01655 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HRR29_RS01660 ENOG410849A acetyltransferase, (GNAT) family HRR29_RS01665 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HRR29_RS01670 ENOG4105FD8 phosphonate metabolism protein PhnM HRR29_RS01675 ENOG4105HRV phosphonate c-p lyase system protein phnl HRR29_RS01680 ENOG4105ENV phosphonate C-P lyase system protein PhnK HRR29_RS01685 ENOG4105FT8 Phosphonate metabolism HRR29_RS01690 ENOG4105EKV Phosphonate metabolism protein HRR29_RS01695 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HRR29_RS01700 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HRR29_RS01705 ENOG4107RJJ Transcriptional regulator HRR29_RS01715 ENOG4105EHI Phosphonate ABC transporter, periplasmic HRR29_RS01720 ENOG4105D5T phosphonate abc transporter HRR29_RS01725 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HRR29_RS01730 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HRR29_RS01735 ENOG4108F5E vimentin HRR29_RS01740 ENOG4108YIV HRR29_RS01745 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HRR29_RS01750 ENOG4105CSH Transporter HRR29_RS01755 ENOG4105D7X high-affinity nickel-transporter HRR29_RS01795 ENOG4108SIC Transcriptional regulator HRR29_RS01800 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HRR29_RS01810 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HRR29_RS01815 ENOG4108IJ0 Aspartate ammonia-lyase HRR29_RS01820 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HRR29_RS01825 ENOG4105DVH amino acid HRR29_RS01840 ENOG4108ZVF (LipO)protein HRR29_RS01845 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HRR29_RS01850 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HRR29_RS01855 ENOG4106BSU Entericidin B HRR29_RS01880 ENOG4106FGB Beta-lactamase HRR29_RS01885 ENOG4105ETT transcriptional Regulator, LysR family HRR29_RS01895 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HRR29_RS01900 ENOG4105E33 succinate dehydrogenase HRR29_RS01905 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HRR29_RS01910 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HRR29_RS01915 ENOG4105EGS Mechanosensitive ion channel HRR29_RS01930 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HRR29_RS01950 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HRR29_RS01955 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HRR29_RS01960 ENOG4105K8N protein family UPF0079, ATPase HRR29_RS01965 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HRR29_RS01970 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HRR29_RS01975 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HRR29_RS01980 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HRR29_RS01985 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HRR29_RS01990 ENOG4107QJR hflk protein HRR29_RS01995 ENOG4105EPW hflc protein HRR29_RS02005 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HRR29_RS02010 ENOG4105KPV Transcriptional regulator HRR29_RS02015 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HRR29_RS02020 ENOG4105C2N RNA methyltransferase TrmH family group 3 HRR29_RS02025 ENOG4105CSH Transporter HRR29_RS02030 ENOG4105CSU acyl-Coa dehydrogenase HRR29_RS02035 ENOG4105C8Q Methyl-accepting chemotaxis HRR29_RS02040 ENOG4105S17 UPF0379 protein yjfN HRR29_RS02045 ENOG4105WSB biofilm stress and motility protein A HRR29_RS02050 ENOG4108MXZ Esterase HRR29_RS02055 ENOG4105KIT UPF0379 protein yjfY HRR29_RS02060 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HRR29_RS02065 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HRR29_RS02070 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HRR29_RS02075 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HRR29_RS02080 ENOG4105FHY Opacity-associated protein A HRR29_RS02085 ENOG4108V1T peptidylprolyl cis-trans isomerase HRR29_RS02095 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HRR29_RS02100 ENOG4105C8Q Methyl-accepting chemotaxis HRR29_RS02105 ENOG4105DXC membrane HRR29_RS02115 ENOG4105CF7 AraC family transcriptional regulator HRR29_RS02120 ENOG4107RX2 synthase HRR29_RS02125 ENOG4105ECR NmrA family HRR29_RS02130 ENOG4105KVH Transcriptional regulator HRR29_RS02135 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HRR29_RS02140 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HRR29_RS02145 ENOG4108UUE Transcriptional regulator HRR29_RS02150 ENOG41061GZ Protein of unknown function (DUF1107) HRR29_RS02155 ENOG4105C37 (CBS) domain HRR29_RS02170 ENOG4105HVQ Regulatory factor of maltose metabolism HRR29_RS02200 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HRR29_RS02205 ENOG4105CFU surface antigen HRR29_RS02210 ENOG4105MA0 exported protein HRR29_RS02215 ENOG4108ZHD aig2 family HRR29_RS02230 ENOG4105F0N pyrophosphate phospho-hydrolase HRR29_RS02235 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HRR29_RS02240 ENOG4105C2J ABC transporter HRR29_RS02245 ENOG4107R9N ABC transporter HRR29_RS02250 ENOG41062B0 ABC transporter, permease HRR29_RS02255 ENOG4105C8Q Methyl-accepting chemotaxis HRR29_RS02270 ENOG4105DFU Cell wall formation (By similarity) HRR29_RS02275 ENOG4105N42 UPF0307 protein HRR29_RS02280 ENOG4105CMS peptidase U62, modulator of DNA gyrase HRR29_RS02285 ENOG4108XVM Cytochrome b(562) HRR29_RS02315 ENOG41069H0 dihydroorotase EC 3.5.2.3 HRR29_RS02335 ENOG4105EMD TRANSCRIPTIONal HRR29_RS02345 ENOG4105K4U addiction module toxin, RelE StbE family HRR29_RS02350 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HRR29_RS02355 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HRR29_RS02360 ENOG4105CG3 alpha amylase, catalytic region HRR29_RS02365 ENOG4105C5Y PTS System HRR29_RS02370 ENOG4105D4X repressor HRR29_RS02380 ENOG4105E2D ec 3.2.1.52 HRR29_RS02385 ENOG4105KME endoribonuclease L-psp HRR29_RS02390 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HRR29_RS02395 ENOG4105CXT aspartate transcarbamylase HRR29_RS02400 ENOG41077AM PyrBI operon attenuator HRR29_RS02410 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HRR29_RS02415 ENOG4105CSX c4-dicarboxylate anaerobic carrier HRR29_RS02420 ENOG4105DBV ornithine carbamoyltransferase HRR29_RS02425 ENOG4105C5B carbamate kinase HRR29_RS02430 ENOG4105CEU Arginine dihydrolase HRR29_RS02435 ENOG4105XEP YhcH YjgK YiaL family protein HRR29_RS02450 ENOG4105DBV ornithine carbamoyltransferase HRR29_RS02455 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HRR29_RS02460 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HRR29_RS02495 ENOG4105DZR Type I site-specific deoxyribonuclease HRR29_RS02570 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HRR29_RS02575 ENOG4105BZU Histidine kinase HRR29_RS02585 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HRR29_RS02590 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HRR29_RS02625 ENOG4105E6M Sulphatase-modifying factor protein HRR29_RS02635 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HRR29_RS02670 ENOG4105EZE Cupin 4 family protein HRR29_RS02675 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HRR29_RS02680 ENOG4106DIZ Domain of unknown function (DUF1127) HRR29_RS02695 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HRR29_RS02700 ENOG410642W LysR family Transcriptional regulator HRR29_RS02705 ENOG4105C26 Dehydrogenase HRR29_RS02715 ENOG4108ZHR arsR family transcriptional regulator HRR29_RS02735 ENOG4106BRA Membrane HRR29_RS02760 ENOG4105C26 Dehydrogenase HRR29_RS02780 ENOG4105CKI cobalamin synthesis protein HRR29_RS02785 ENOG4105VCD cytoplasmic protein HRR29_RS02790 ENOG4105D22 carbon starvation protein HRR29_RS02800 ENOG4107UWN reductase HRR29_RS02805 ENOG4105EFA 4-hydroxyphenylacetate HRR29_RS02820 ENOG4105CNV Aldolase HRR29_RS02835 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HRR29_RS02840 ENOG4105C26 Dehydrogenase HRR29_RS02845 ENOG4105ERH Fumarylacetoacetate hydrolase HRR29_RS02850 ENOG4108V8F Transcriptional regulator, MarR family HRR29_RS02855 ENOG4105C8Q Methyl-accepting chemotaxis HRR29_RS02860 ENOG4105XYF acetyltransferase HRR29_RS02870 ENOG4105RI1 glycoprotein receptor HRR29_RS02875 ENOG4106CVF DNA replication protein HRR29_RS02880 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HRR29_RS02885 ENOG4108ZHJ Organic hydroperoxide resistance protein HRR29_RS02890 ENOG4105K56 Transcriptional regulator HRR29_RS02900 ENOG4107XM3 UPF0442 protein HRR29_RS02905 ENOG4105DWK Membrane HRR29_RS02910 ENOG4108N8T regulatoR HRR29_RS02915 ENOG4108T94 DNA-binding transcriptional activator BglJ HRR29_RS02920 ENOG4108UIN ybak prolyl-trna synthetase associated region HRR29_RS02925 ENOG4105CK1 PTS System HRR29_RS02930 ENOG4108819 ferric iron reductase HRR29_RS02935 ENOG4106TD9 Diguanylate cyclase HRR29_RS02940 ENOG4105YBH Protein of unknown function (DUF1435) HRR29_RS02960 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HRR29_RS02965 ENOG4108WPU DNA polymerase III subunit psi HRR29_RS02970 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HRR29_RS02975 ENOG4105PAD Hydrolase HRR29_RS02980 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HRR29_RS02985 ENOG4105K3G Periplasmic Protein HRR29_RS02995 ENOG4108NRW Phospholipase, patatin family HRR29_RS03000 ENOG4105EYA deoxyribonuclease HRR29_RS03005 ENOG41076CZ activating enzyme HRR29_RS03010 ENOG4105G0K glycine radical enzyme YjjI family HRR29_RS03020 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HRR29_RS03030 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HRR29_RS03035 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HRR29_RS03040 ENOG41062Z9 Membrane HRR29_RS03045 ENOG4105EAC phosphoserine phosphatase HRR29_RS03050 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HRR29_RS03055 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HRR29_RS03070 ENOG4105C5H ABC transporter HRR29_RS03075 ENOG4107SC1 transglycosylase HRR29_RS03080 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HRR29_RS03085 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HRR29_RS03090 ENOG4105CVJ phosphoglycerate mutase HRR29_RS03095 ENOG4105UEI Transcriptional Regulator AraC Family HRR29_RS03100 ENOG4108RH0 Crea protein HRR29_RS03105 ENOG4105E3W Two component transcriptional regulator (Winged helix family HRR29_RS03110 ENOG4105EB3 Histidine kinase HRR29_RS03115 ENOG4105CT7 inner membrane cred family protein HRR29_RS03120 ENOG41065U4 response regulator HRR29_RS03125 ENOG410759A HRR29_RS03130 ENOG4106FVC RNA methyltransferase HRR29_RS03140 ENOG4105CFH Aspartokinase HRR29_RS03150 ENOG4105D98 threonine synthase HRR29_RS03155 ENOG41062C6 Protein of unknown function (DUF2502) HRR29_RS03160 ENOG4105D1Q UPF0246 protein HRR29_RS03165 ENOG4105BZG amino acid carrier protein HRR29_RS03170 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HRR29_RS03175 ENOG4108RIR Molybdenum cofactor biosynthesis protein HRR29_RS03180 ENOG4105CSH Transporter HRR29_RS03185 ENOG4106HK8 GPR1 FUN34 yaaH family protein HRR29_RS03190 ENOG4105CFG Acts as a chaperone (By similarity) HRR29_RS03195 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HRR29_RS03200 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HRR29_RS03205 ENOG41063Z6 transcriptional regulator, lysR family HRR29_RS03210 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HRR29_RS03220 ENOG4105DTN riboflavin biosynthesis protein ribF HRR29_RS03225 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HRR29_RS03235 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HRR29_RS03240 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HRR29_RS03245 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HRR29_RS03250 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HRR29_RS03255 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HRR29_RS03260 ENOG4105M5B (LipO)protein HRR29_RS03265 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HRR29_RS03270 ENOG4105CKD glutathione-regulated potassium-efflux system protein HRR29_RS03275 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HRR29_RS03280 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HRR29_RS03285 ENOG4105NWN ApaG protein HRR29_RS03290 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HRR29_RS03295 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HRR29_RS03300 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HRR29_RS03305 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HRR29_RS03310 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HRR29_RS03315 ENOG4105D3G Pseudouridine synthase HRR29_RS03320 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HRR29_RS03325 ENOG4105CQ2 DNA polymerase HRR29_RS03330 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HRR29_RS03335 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HRR29_RS03340 ENOG4105EF1 ribulokinase HRR29_RS03350 ENOG4108KF1 Membrane HRR29_RS03360 ENOG4106SMU thiamine transporter membrane protein HRR29_RS03380 ENOG4105S8Q sugar efflux transporter HRR29_RS03390 ENOG41076HS cation diffusion facilitator family transporter HRR29_RS03395 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HRR29_RS03400 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HRR29_RS03410 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HRR29_RS03420 ENOG41064T2 transcriptional regulator, lysR family HRR29_RS03425 ENOG4105C7K acetolactate synthase HRR29_RS03430 ENOG4108ZP8 Acetolactate synthase small subunit HRR29_RS03435 ENOG4107B7Y DNA-binding transcriptional regulator FruR HRR29_RS03440 ENOG4108V6E Cell division protein mraZ HRR29_RS03450 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HRR29_RS03455 ENOG4105CJN penicillin-binding protein HRR29_RS03460 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HRR29_RS03465 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HRR29_RS03470 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HRR29_RS03480 ENOG4105CNI cell division protein FtsW HRR29_RS03485 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HRR29_RS03490 ENOG4105DFU Cell wall formation (By similarity) HRR29_RS03495 ENOG4105CPF Cell wall formation (By similarity) HRR29_RS03500 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HRR29_RS03505 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HRR29_RS03510 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HRR29_RS03515 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HRR29_RS03520 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HRR29_RS03525 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HRR29_RS03530 ENOG4105M6F mutator MutT protein HRR29_RS03535 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HRR29_RS03540 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HRR29_RS03545 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HRR29_RS03550 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HRR29_RS03560 ENOG4107QHF type ii secretion system protein e HRR29_RS03565 ENOG4108ZUW Major pilin subunit HRR29_RS03615 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HRR29_RS03620 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HRR29_RS03625 ENOG4106A72 regulatory protein AmpE HRR29_RS03630 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HRR29_RS03635 ENOG4105CT4 transporter HRR29_RS03640 ENOG4105C85 amino acid HRR29_RS03650 ENOG41073TP transcriptional regulator HRR29_RS03655 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HRR29_RS03660 ENOG4107QSN dihydrolipoamide acetyltransferase HRR29_RS03665 ENOG4107QN2 dihydrolipoyl dehydrogenase HRR29_RS03675 ENOG4108NST exported protein HRR29_RS03680 ENOG4107QIJ Aconitate hydratase 2 HRR29_RS03690 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HRR29_RS03695 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HRR29_RS03700 ENOG4108ZRK uncharacterized protein yacC HRR29_RS03705 ENOG4105E3B Multicopper oxidase HRR29_RS03710 ENOG4105DZG Dehydrogenase HRR29_RS03715 ENOG4108UGV hypoxanthine phosphoribosyltransferase HRR29_RS03720 ENOG41077A9 carbonic anhydrase HRR29_RS03725 ENOG4105DA5 (ABC) transporter HRR29_RS03730 ENOG4105E3A (ABC) transporter HRR29_RS03735 ENOG4108YTN IIa component HRR29_RS03740 ENOG4107BJW polysaccharide deacetylase HRR29_RS03745 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HRR29_RS03750 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HRR29_RS03755 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HRR29_RS03760 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HRR29_RS03765 ENOG4105DJ0 Poly(A) Polymerase HRR29_RS03770 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HRR29_RS03775 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HRR29_RS03780 ENOG4105PW4 Sugar fermentation stimulation protein homolog HRR29_RS03785 ENOG4107XID 2'-5' rna ligase HRR29_RS03790 ENOG4105CQ7 ATP-dependent helicase HRR29_RS03795 ENOG4105BZ4 penicillin-binding protein HRR29_RS03800 ENOG4105E0K tonB-dependent siderophore receptor HRR29_RS03805 ENOG4105E0A ABC, transporter HRR29_RS03810 ENOG4105J76 Periplasmic binding protein HRR29_RS03815 ENOG4105S6R Iron-hydroxamate transporter permease subunit HRR29_RS03820 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HRR29_RS03825 ENOG4105CMQ Chloride channel HRR29_RS03830 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HRR29_RS03835 ENOG4105EN6 Membrane HRR29_RS03845 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HRR29_RS03850 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HRR29_RS03855 ENOG4105C0H protease HRR29_RS03860 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HRR29_RS03865 ENOG4108T8E UPF0325 protein HRR29_RS03870 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HRR29_RS03875 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HRR29_RS03880 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HRR29_RS03890 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HRR29_RS03895 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HRR29_RS03905 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HRR29_RS03915 ENOG4105KNE Phosphatidate cytidylyltransferase HRR29_RS03920 ENOG4105DZP Membrane-associated zinc metalloprotease HRR29_RS03925 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HRR29_RS03930 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HRR29_RS03935 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HRR29_RS03940 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HRR29_RS03945 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HRR29_RS03950 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HRR29_RS03955 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HRR29_RS03960 ENOG4105C0B DNA polymerase III (alpha subunit) HRR29_RS03965 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HRR29_RS03970 ENOG4105CXN decarboxylase HRR29_RS03975 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HRR29_RS03980 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HRR29_RS03985 ENOG4105M1T rho-binding antiterminator HRR29_RS03990 ENOG4105W1I UPF0253 protein HRR29_RS03995 ENOG4108VWS Yaeq family HRR29_RS04000 ENOG4108YZN class I peptide chain release factor HRR29_RS04005 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HRR29_RS04015 ENOG4108R96 Methyltransferase, YaeB family HRR29_RS04020 ENOG4108R8X outer membrane lipoprotein HRR29_RS04025 ENOG4105D01 (LipO)protein HRR29_RS04030 ENOG4108UMI ABC transporter, permease HRR29_RS04035 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HRR29_RS04040 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HRR29_RS04075 ENOG4105CV8 reductase HRR29_RS04080 ENOG4105HEI LysR family (Transcriptional regulator HRR29_RS04085 ENOG4105F27 Major Facilitator HRR29_RS04090 ENOG4107NA1 Endonuclease Exonuclease phosphatase HRR29_RS04095 ENOG4105F2W methyltransferase HRR29_RS04100 ENOG4105E9H Lytic Murein transglycosylase HRR29_RS04105 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HRR29_RS04110 ENOG4105D1A Methyltransferase HRR29_RS04120 ENOG4107RZZ dna polymerase iii epsilon subunit HRR29_RS04135 ENOG4105C3U ABC transporter HRR29_RS04140 ENOG4108JQ7 (ABC) transporter HRR29_RS04155 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRR29_RS04160 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HRR29_RS04165 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HRR29_RS04170 ENOG4107QPN acyl-Coa dehydrogenase HRR29_RS04180 ENOG4105E7A Glutamine amidotransferase HRR29_RS04185 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HRR29_RS04200 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HRR29_RS04205 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HRR29_RS04210 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HRR29_RS04215 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HRR29_RS04225 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HRR29_RS04230 ENOG4105CIN aminoacyl-histidine dipeptidase HRR29_RS04235 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HRR29_RS04240 ENOG4105V1F Fermentation respiration switch protein HRR29_RS04245 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HRR29_RS04250 ENOG4105FCK Membrane HRR29_RS04255 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HRR29_RS04260 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HRR29_RS04270 ENOG4105DFP Integrase HRR29_RS04290 ENOG4105XB7 anti-repressor protein HRR29_RS04350 ENOG4108UY2 Chloramphenicol acetyltransferase HRR29_RS04355 ENOG4105BZU Histidine kinase HRR29_RS04385 ENOG4105F4G Membrane HRR29_RS04395 ENOG4108IQI permease HRR29_RS04400 ENOG4107QK5 Homocysteine s-methyltransferase HRR29_RS04405 ENOG4106FTQ Taurine ABC transporter, periplasmic HRR29_RS04410 ENOG4108ETV ABC transporter HRR29_RS04415 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HRR29_RS04420 ENOG4105E2B Taurine dioxygenase HRR29_RS04430 ENOG4105D52 delta-aminolevulinic acid dehydratase HRR29_RS04435 ENOG4108NSE outer membrane autotransporter barrel HRR29_RS04440 ENOG4108PNB DNA-binding transcriptional regulator HRR29_RS04445 ENOG4107R6D beta-lactam binding protein AmpH HRR29_RS04455 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HRR29_RS04460 ENOG4107QS8 (LipO)protein HRR29_RS04465 ENOG4105FR5 inner membrane protein YaiY HRR29_RS04470 ENOG4105UNH Membrane HRR29_RS04475 ENOG4105CPF Cell wall formation (By similarity) HRR29_RS04490 ENOG4105RZQ Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway (By similarity) HRR29_RS04495 ENOG4105G6Z alkaline phosphatase HRR29_RS04500 ENOG4105VIF phosphate starvation-inducible protein HRR29_RS04505 ENOG4105BZU Histidine kinase HRR29_RS04510 ENOG4105II7 pyrroline-5-carboxylate reductase HRR29_RS04515 ENOG4108UPT UPF0178 protein HRR29_RS04520 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HRR29_RS04525 ENOG4105SS3 HRR29_RS04530 ENOG4105HBA AroM protein HRR29_RS04535 ENOG4105NBK UPF0345 protein HRR29_RS04545 ENOG4105DKQ ROK family HRR29_RS04550 ENOG4105EYH Exonuclease HRR29_RS04555 ENOG4107RH8 nuclease SbcCD subunit D HRR29_RS04565 ENOG4105BZU Histidine kinase HRR29_RS04570 ENOG4105CWM branched-chain amino acid transport system II carrier protein HRR29_RS04575 ENOG4105C85 amino acid HRR29_RS04580 ENOG4107R28 alpha amylase, catalytic region HRR29_RS04595 ENOG4105D3R alkyl hydroperoxide reductase HRR29_RS04600 ENOG4108ZYK Acyl carrier protein phosphodiesterase HRR29_RS04610 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HRR29_RS04615 ENOG4105VIE preprotein translocase, subunit YajC HRR29_RS04620 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HRR29_RS04625 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HRR29_RS04640 ENOG4105DRB nucleoside-specific channel-forming protein HRR29_RS04645 ENOG4108KIC (LipO)protein HRR29_RS04650 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HRR29_RS04655 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HRR29_RS04660 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HRR29_RS04665 ENOG4107YIM Involved in the transcription termination process (By similarity) HRR29_RS04670 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HRR29_RS04675 ENOG4105CPC Aldo Keto reductase HRR29_RS04680 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HRR29_RS04685 ENOG4105CTB Polyprenyl synthetase HRR29_RS04690 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HRR29_RS04700 ENOG4107S0N DJ-1 family HRR29_RS04705 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HRR29_RS04710 ENOG4108VPT UPF0234 protein HRR29_RS04715 ENOG4107RDB Major Facilitator HRR29_RS04720 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HRR29_RS04725 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HRR29_RS04730 ENOG4105CCU oxidase (Subunit III) HRR29_RS04735 ENOG4105BZ9 Cytochrome C oxidase, subunit I HRR29_RS04740 ENOG4105E2S oxidase) subunit II HRR29_RS04745 ENOG4105EYM Major Facilitator superfamily HRR29_RS04750 ENOG4105IEY (LipO)protein HRR29_RS04755 ENOG4105M85 Bola protein HRR29_RS04760 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HRR29_RS04770 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HRR29_RS04775 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HRR29_RS04780 ENOG4105K70 DNA-binding protein HRR29_RS04785 ENOG4105EIN peptidylprolyl cis-trans isomerase HRR29_RS04790 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HRR29_RS04795 ENOG4108TGP Thioesterase superfamily protein HRR29_RS04800 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HRR29_RS04805 ENOG4108NFA extracellular solute-binding protein HRR29_RS04810 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HRR29_RS04820 ENOG4108XM1 transcriptional regulator AsnC family HRR29_RS04825 ENOG4105BZ1 (ABC) transporter HRR29_RS04830 ENOG4105BZ1 (ABC) transporter HRR29_RS04835 ENOG4108YZA Nitrogen regulatory protein pii HRR29_RS04840 ENOG4105BZU Histidine kinase HRR29_RS04845 ENOG4105C29 acyl-CoA thioesterase HRR29_RS04850 ENOG4108MNP Glycoprotein polysaccharide metabolism HRR29_RS04855 ENOG41080UX Methyltransferase HRR29_RS04875 ENOG4107U9B transcriptional regulator HRR29_RS04880 ENOG4108VW9 Membrane HRR29_RS04885 ENOG4105ETE Transcriptional regulator (LacI family HRR29_RS04895 ENOG41061MD high-affinity nickel-transporter HRR29_RS04905 ENOG41066DG (EAL) domain protein HRR29_RS04910 ENOG4105NRA 50s ribosomal protein l31 type b HRR29_RS04915 ENOG4105YK5 50S ribosomal protein L36 HRR29_RS04930 ENOG4105GSJ Inner membrane protein ylaC HRR29_RS04935 ENOG4108UW5 maltose o-acetyltransferase HRR29_RS04945 ENOG4108UKR Biofilm formation regulator YbaJ HRR29_RS04950 ENOG4105BZS acriflavin resistance protein HRR29_RS04955 ENOG4105C1P efflux transporter, rnd family, mfp subunit HRR29_RS04960 ENOG4107XI7 Tetr family transcriptional regulator HRR29_RS04965 ENOG4105EGS Mechanosensitive ion channel HRR29_RS04970 ENOG4106428 Protein of unknown function (DUF2496) HRR29_RS04975 ENOG4108URS primosomal replication protein n'' HRR29_RS04980 ENOG4105WD1 Membrane HRR29_RS04985 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HRR29_RS04990 ENOG4107QMP dna polymerase iii subunits gamma and tau HRR29_RS04995 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HRR29_RS05000 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HRR29_RS05005 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HRR29_RS05010 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HRR29_RS05015 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HRR29_RS05020 ENOG4107RE1 Inosine-guanosine kinase HRR29_RS05025 ENOG4105CKD glutathione-regulated potassium-efflux system protein HRR29_RS05030 ENOG4105EU0 Major facilitator Superfamily HRR29_RS05035 ENOG4105CGH 5'-nucleotidase HRR29_RS05040 ENOG4108Z66 YbaK ebsC protein HRR29_RS05045 ENOG4105MBR gumn family HRR29_RS05050 ENOG4105C59 p-type ATPase HRR29_RS05055 ENOG4108Z6Z Transcriptional regulator HRR29_RS05060 ENOG4105G5H Membrane HRR29_RS05065 ENOG4107QX8 SPFH domain, Band 7 family protein HRR29_RS05075 ENOG41083J0 (ABC) transporter HRR29_RS05080 ENOG4105C4B ABC transporter, permease HRR29_RS05085 ENOG4107QR8 Thioredoxin HRR29_RS05090 ENOG4105E1F short-chain dehydrogenase reductase HRR29_RS05095 ENOG4108UJV acyl-CoA thioesterase i HRR29_RS05100 ENOG4108I0Y (ABC) transporter HRR29_RS05105 ENOG4105CV6 ABC transporter, permease HRR29_RS05165 ENOG4105EKQ RNA-directed DNA polymerase HRR29_RS05180 ENOG4105W1Y Transcriptional regulator HRR29_RS05195 ENOG4105EQR Transposase IS116 IS110 IS902 HRR29_RS05235 ENOG4105BZU Histidine kinase HRR29_RS05245 ENOG4108BUD transposase HRR29_RS05270 ENOG4108K3A Glutathione S-transferase HRR29_RS05275 ENOG4105GZI Transcriptional regulator HRR29_RS05285 ENOG4108MEJ flavin reductase domain protein HRR29_RS05300 ENOG4108Z3N Transcriptional regulator HRR29_RS05320 ENOG4105Y49 secretion protein, HlyD family HRR29_RS05330 ENOG4105DSW Fusaric acid resistance protein HRR29_RS05335 ENOG4105R1U AraC Family Transcriptional Regulator HRR29_RS05345 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HRR29_RS05355 ENOG4105ENT Efflux transporter rnd family, mfp subunit HRR29_RS05365 ENOG4105WQ6 Membrane HRR29_RS05370 ENOG4105HFT AraC family transcriptional regulator HRR29_RS05380 ENOG41067SE Tetr family transcriptional regulator HRR29_RS05385 ENOG4105MSB protein, conserved in bacteria HRR29_RS05390 ENOG4108RCM Nitroreductase HRR29_RS05395 ENOG4105CKT filamentous hemagglutinin HRR29_RS05400 ENOG4105D5K Hemolysin activator protein HRR29_RS05425 ENOG4105Q7J Fimbrial HRR29_RS05430 ENOG4105CW0 outer membrane usher protein HRR29_RS05435 ENOG4108AF8 Chaperone HRR29_RS05440 ENOG4106EAR Fimbrial protein HRR29_RS05445 ENOG4106EAR Fimbrial protein HRR29_RS05450 ENOG4108VCD Chaperone HRR29_RS05460 ENOG4108PNB DNA-binding transcriptional regulator HRR29_RS05475 ENOG4105CUY Mechanosensitive ion channel HRR29_RS05480 ENOG4105C85 amino acid HRR29_RS05490 ENOG4105TDT uncharacterized protein yahO HRR29_RS05530 ENOG4108Q9V regulatoR HRR29_RS05540 ENOG4105CW0 outer membrane usher protein HRR29_RS05545 ENOG4108AF8 Chaperone HRR29_RS05550 ENOG4105NJT Fimbrial protein HRR29_RS05555 ENOG4108WDE Fimbrial protein HRR29_RS05560 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HRR29_RS05565 ENOG4105WQ3 Rna-binding protein HRR29_RS05570 ENOG4105CI1 PTS System HRR29_RS05575 ENOG4107P2S Transcriptional regulator HRR29_RS05580 ENOG4105S2T inner membrane protein YbcI HRR29_RS05585 ENOG4105C8N cysteinyl-tRNA synthetase HRR29_RS05590 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HRR29_RS05595 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HRR29_RS05610 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HRR29_RS05615 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HRR29_RS05635 ENOG41061MD high-affinity nickel-transporter HRR29_RS05645 ENOG4105GR3 Histidine kinase HRR29_RS05655 ENOG4105DIJ Phosphoethanolamine transferase HRR29_RS05665 ENOG4105DHQ Histidine kinase HRR29_RS05670 ENOG4105XJC Two component transcriptional regulator (Winged helix family HRR29_RS05685 ENOG4108BUD transposase HRR29_RS05690 ENOG4105EQR Transposase IS116 IS110 IS902 HRR29_RS05735 ENOG410624V efflux system protein HRR29_RS05780 ENOG4105C7K acetolactate synthase HRR29_RS05785 ENOG4105CHR reductase HRR29_RS05795 ENOG4108JQ7 (ABC) transporter HRR29_RS05800 ENOG4105C3U ABC transporter HRR29_RS05805 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRR29_RS05810 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRR29_RS05830 ENOG4105EMU Dehydrogenase HRR29_RS05865 ENOG4105C94 Transporter HRR29_RS05870 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HRR29_RS05880 ENOG4108TSE Transferase HRR29_RS05885 ENOG4107RNH Outer membrane receptor FepA HRR29_RS05890 ENOG4105E93 esterase HRR29_RS05895 ENOG41085A6 mbth domain-containing protein HRR29_RS05900 ENOG4105C0W non-ribosomal peptide synthetase HRR29_RS05905 ENOG4105E0A ABC, transporter HRR29_RS05910 ENOG4105TVJ transport system, permease HRR29_RS05915 ENOG4105DQ5 transport system permease protein HRR29_RS05925 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HRR29_RS05930 ENOG4105E4F Isochorismate synthase HRR29_RS05935 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HRR29_RS05940 ENOG4105WQI isochorismatase HRR29_RS05945 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HRR29_RS05950 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HRR29_RS05955 ENOG4105D22 carbon starvation protein HRR29_RS05960 ENOG4105VCD cytoplasmic protein HRR29_RS05975 ENOG4105CHR reductase HRR29_RS05980 ENOG4107SCQ Iron-containing alcohol dehydrogenase HRR29_RS05985 ENOG4105C2J ABC transporter HRR29_RS05990 ENOG4105CNN ABC, transporter HRR29_RS06005 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HRR29_RS06010 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HRR29_RS06020 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HRR29_RS06025 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HRR29_RS06030 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HRR29_RS06035 ENOG4105CHM Aminotransferase HRR29_RS06040 ENOG4105GTN ParB Domain Protein Nuclease HRR29_RS06045 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HRR29_RS06050 ENOG4105DQS Transcriptional regulator HRR29_RS06055 ENOG4105D3R alkyl hydroperoxide reductase HRR29_RS06060 ENOG4108JU3 Alkyl hydroperoxide reductase HRR29_RS06065 ENOG4108U51 Universal stress protein HRR29_RS06070 ENOG4105E2A Dehydrogenase HRR29_RS06075 ENOG4105NXH GreA GreB family elongation factor HRR29_RS06080 ENOG4105EW6 flavin reductase domain protein, FMN-binding HRR29_RS06085 ENOG4105KTS ribonuclease HRR29_RS06090 ENOG4105CEE C4-dicarboxylate transporter HRR29_RS06095 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HRR29_RS06105 ENOG4107Z6W Protein CrcB homolog HRR29_RS06115 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HRR29_RS06120 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HRR29_RS06125 ENOG41064T2 transcriptional regulator, lysR family HRR29_RS06130 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HRR29_RS06135 ENOG4108Z43 UPF0250 protein HRR29_RS06140 ENOG4105DZ1 carboxypeptidase HRR29_RS06145 ENOG4105K6T rare lipoprotein A HRR29_RS06150 ENOG4105CNI cell division protein FtsW HRR29_RS06155 ENOG4105CJN penicillin-binding protein HRR29_RS06160 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HRR29_RS06165 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HRR29_RS06175 ENOG4105DJF DNA polymerase III, delta' subunit HRR29_RS06185 ENOG4105C8T Leucyl-tRNA synthetase HRR29_RS06190 ENOG4107PAI alpha helical protein HRR29_RS06195 ENOG4105DU0 nucleoside hydrolase HRR29_RS06200 ENOG4105CDA abc transporter atp-binding protein HRR29_RS06205 ENOG4105DRP amino acid AbC transporter HRR29_RS06210 ENOG4105EAD ABC transporter HRR29_RS06215 ENOG4107RP9 extracellular solute-binding protein, family 3 HRR29_RS06220 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HRR29_RS06225 ENOG4108JU5 Magnesium and cobalt efflux protein HRR29_RS06230 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HRR29_RS06235 ENOG4105C9A Phoh family HRR29_RS06240 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HRR29_RS06245 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HRR29_RS06285 ENOG4105CAQ asparagine synthetase HRR29_RS06290 ENOG4105D4U had-superfamily hydrolase, subfamily iia HRR29_RS06295 ENOG4105E2R ROK family HRR29_RS06300 ENOG4105CE4 GlcNAc 6-P deacetylase HRR29_RS06310 ENOG4105CI1 PTS System HRR29_RS06315 ENOG4105CX6 glutaminyL-tRNA synthetase HRR29_RS06325 ENOG4105GX6 (LipO)protein HRR29_RS06330 ENOG41090R7 Ferric uptake HRR29_RS06340 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HRR29_RS06345 ENOG4105NNH LexA regulated protein HRR29_RS06350 ENOG4105EV9 Alpha Beta Hydrolase HRR29_RS06355 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HRR29_RS06360 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HRR29_RS06365 ENOG4105D5Q Arginine ornithine antiporter HRR29_RS06370 ENOG4105CXN decarboxylase HRR29_RS06380 ENOG4105EEX Two component transcriptional regulator (Winged helix family HRR29_RS06385 ENOG4105C08 Histidine kinase HRR29_RS06390 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HRR29_RS06395 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HRR29_RS06400 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HRR29_RS06410 ENOG4105XIQ Protein of unknown function (DUF2517) HRR29_RS06415 ENOG4105CVP deoxyribo-dipyrimidine photolyase HRR29_RS06420 ENOG4107QNR UPF0135 protein HRR29_RS06425 ENOG4105P4J Allophanate hydrolase, subunit 1 HRR29_RS06430 ENOG4107R7A Allophanate hydrolase subunit 2 HRR29_RS06440 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HRR29_RS06445 ENOG4105BZN citrate synthase HRR29_RS06450 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HRR29_RS06455 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HRR29_RS06460 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HRR29_RS06465 ENOG4105E33 succinate dehydrogenase HRR29_RS06470 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HRR29_RS06475 ENOG4105C7S Dehydrogenase HRR29_RS06480 ENOG4105CMV Succinyl-CoA synthetase subunit beta HRR29_RS06485 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HRR29_RS06490 ENOG4105C4M (Ubiquinol oxidase) subunit I HRR29_RS06495 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HRR29_RS06505 ENOG4105KJB cyd operon protein YbgE HRR29_RS06510 ENOG4107YD3 Thioesterase HRR29_RS06515 ENOG4105E02 MotA TolQ exbB proton channel HRR29_RS06525 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HRR29_RS06535 ENOG4105KCK Peptidoglycan-associated lipoprotein HRR29_RS06540 ENOG4105UFD tol-pal system protein YbgF HRR29_RS06570 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HRR29_RS06575 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HRR29_RS06580 ENOG4105PGM cation diffusion facilitator family transporter HRR29_RS06585 ENOG4105JND homeobox protein HRR29_RS06590 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HRR29_RS06595 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HRR29_RS06600 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HRR29_RS06605 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HRR29_RS06610 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HRR29_RS06615 ENOG4105CMR udp-glucose 4-epimerase HRR29_RS06620 ENOG4105DKW ABC transporter HRR29_RS06625 ENOG4105F4R Transcriptional regulator mode HRR29_RS06635 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HRR29_RS06640 ENOG4105E0C molybdate abc transporter HRR29_RS06650 ENOG4108K4B hydrolase HRR29_RS06655 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HRR29_RS06660 ENOG4105NBR Pectinesterase HRR29_RS06665 ENOG4105CI2 imidazolone-5-propionate hydrolase HRR29_RS06670 ENOG41088SP formiminoglutamate hydrolase HRR29_RS06680 ENOG4105CGP Urocanate hydratase HRR29_RS06685 ENOG4105C84 Histidine ammonia-lyase HRR29_RS06690 ENOG4108V1U phospholipid-binding protein HRR29_RS06695 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HRR29_RS06700 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HRR29_RS06705 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HRR29_RS06710 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HRR29_RS06715 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HRR29_RS06720 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HRR29_RS06730 ENOG4105CHW UPF0052 protein HRR29_RS06735 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HRR29_RS06740 ENOG4108RIR Molybdenum cofactor biosynthesis protein HRR29_RS06745 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HRR29_RS06750 ENOG4105M00 molybdopterin converting factor, subunit 1 HRR29_RS06755 ENOG4108ZAF Molybdopterin HRR29_RS06760 ENOG4105HFZ Membrane HRR29_RS06765 ENOG4107UXM Membrane HRR29_RS06770 ENOG4105DZQ phospholipase D Transphosphatidylase HRR29_RS06775 ENOG4105X23 Endonuclease Exonuclease phosphatase HRR29_RS06780 ENOG4105I9U inner membrane protein ybhQ HRR29_RS06785 ENOG4107QWP ABC-2 type transporter HRR29_RS06790 ENOG4107QWP ABC-2 type transporter HRR29_RS06795 ENOG4105CJ1 ABC, transporter HRR29_RS06800 ENOG4105D0S secretion protein (HlyD HRR29_RS06805 ENOG4107MVR Transcriptional regulator HRR29_RS06810 ENOG4105C1J atp-dependent rna helicase HRR29_RS06815 ENOG4105DVT helicase HRR29_RS06830 ENOG4105CW0 outer membrane usher protein HRR29_RS06835 ENOG4108UIF Chaperone HRR29_RS06845 ENOG4108MTB glycosyl transferase family HRR29_RS06850 ENOG4105VR4 UPF0379 protein ybiJ HRR29_RS06855 ENOG4105KSC Transcriptional regulator, TraR DksA family HRR29_RS06860 ENOG4105ZY9 UPF0379 protein ybiM HRR29_RS06865 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HRR29_RS06870 ENOG4105D8X mechanosensitive ion channel HRR29_RS06875 ENOG4105CDA abc transporter atp-binding protein HRR29_RS06880 ENOG4105E5Q amino acid AbC transporter HRR29_RS06885 ENOG4107R0W ABC transporter HRR29_RS06890 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HRR29_RS06900 ENOG4108T1M outer membrane protein x HRR29_RS06905 ENOG4108I6E Sulfatase HRR29_RS06915 ENOG4105KST dependent repressor HRR29_RS06920 ENOG4105F4P )-transporter HRR29_RS06925 ENOG4105CW7 secretion protein, HlyD family HRR29_RS06930 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRR29_RS06940 ENOG4105CPC Aldo Keto reductase HRR29_RS06945 ENOG4105CS2 ec 3.2.1.21 HRR29_RS06955 ENOG4105K4U addiction module toxin, RelE StbE family HRR29_RS06985 ENOG4105FDP GntR family transcriptional regulator HRR29_RS06990 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HRR29_RS07000 ENOG4105F2I Transposase HRR29_RS07050 ENOG4107TII Recombinase HRR29_RS07055 ENOG4105C5H ABC transporter HRR29_RS07065 ENOG4105DPW Major facilitator superfamily MFS_1 HRR29_RS07070 ENOG4105ETE Transcriptional regulator (LacI family HRR29_RS07075 ENOG41072TH Protein of unknown function (DUF1479) HRR29_RS07080 ENOG4108HCJ Hydrolase HRR29_RS07090 ENOG4105F1A Pyruvate formate-lyase HRR29_RS07095 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HRR29_RS07100 ENOG4105D06 uba thif-type nad fad binding protein HRR29_RS07105 ENOG4105CVM Molybdenum cofactor synthesis domain protein HRR29_RS07110 ENOG4105D44 asparaginase HRR29_RS07115 ENOG4108JQ6 ABC transporter HRR29_RS07155 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HRR29_RS07160 ENOG4105D8V Glucose sorbosone dehydrogenase HRR29_RS07165 ENOG4108TGY Glutathione S-transferase HRR29_RS07170 ENOG4105DZ1 carboxypeptidase HRR29_RS07175 ENOG4107FB0 transcriptional regulator DeoR family HRR29_RS07180 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HRR29_RS07190 ENOG4107QF7 multi-drug HRR29_RS07195 ENOG4108HCJ Hydrolase HRR29_RS07200 ENOG4106UW1 Major Facilitator superfamily HRR29_RS07205 ENOG4108RFG Tetr family transcriptional regulator HRR29_RS07225 ENOG4105KBH arsR family transcriptional regulator HRR29_RS07230 ENOG4105D0C transport protein HRR29_RS07235 ENOG4105GWF inner membrane protein YbjM HRR29_RS07240 ENOG41090BQ Glutaredoxin HRR29_RS07245 ENOG4108DBC nitroreductase HRR29_RS07250 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HRR29_RS07255 ENOG4108RMJ sensory transduction regulator HRR29_RS07260 ENOG4107RUE extracellular solute-binding protein family 1 HRR29_RS07265 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HRR29_RS07270 ENOG4105F38 ABC transporter, permease HRR29_RS07275 ENOG4105D38 putrescine abc transporter HRR29_RS07280 ENOG4105RBQ inner membrane protein ybjO HRR29_RS07285 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HRR29_RS07290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HRR29_RS07295 ENOG4105BZU Histidine kinase HRR29_RS07300 ENOG4106TNF Periplasmic binding protein HRR29_RS07305 ENOG4105DMR ABC, transporter HRR29_RS07310 ENOG4105GBT ABC transporter HRR29_RS07315 ENOG4106PMH Extracellular solute-binding protein family 3 HRR29_RS07320 ENOG4105E5Z arginine transporter ATP-binding subunit HRR29_RS07325 ENOG41064MM (LipO)protein HRR29_RS07330 ENOG4105K8R UPF0145 protein HRR29_RS07335 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HRR29_RS07340 ENOG4108PNB DNA-binding transcriptional regulator HRR29_RS07350 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression HRR29_RS07355 ENOG4108XKW General secretion pathway protein C HRR29_RS07360 ENOG4105GVR general secretion pathway protein D HRR29_RS07365 ENOG4107QHF type ii secretion system protein e HRR29_RS07370 ENOG4105D7Q type ii secretion system HRR29_RS07375 ENOG4108VAU general secretion pathway protein G HRR29_RS07385 ENOG4105X5Z General secretion pathway protein I HRR29_RS07395 ENOG4108RTD type II secretion system protein K HRR29_RS07410 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HRR29_RS07430 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HRR29_RS07435 ENOG4105CGD Nad-dependent epimerase dehydratase HRR29_RS07440 ENOG4105C5W Aldolase HRR29_RS07445 ENOG4105C7K acetolactate synthase HRR29_RS07455 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HRR29_RS07460 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HRR29_RS07465 ENOG4105DWU Membrane HRR29_RS07470 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HRR29_RS07475 ENOG4105CPB ATP-dependent endonuclease of the OLD family HRR29_RS07480 ENOG4108MJ5 VirK protein HRR29_RS07485 ENOG4105DJY efflux transporter, rnd family, mfp subunit HRR29_RS07495 ENOG4105VEQ Cold shock protein HRR29_RS07500 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HRR29_RS07505 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HRR29_RS07545 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HRR29_RS07550 ENOG4108JJ8 (ABC) transporter HRR29_RS07555 ENOG4108JJ9 ABC, transporter HRR29_RS07560 ENOG4105C3M thioredoxin reductase HRR29_RS07565 ENOG4105EW9 transcriptional regulator AsnC family HRR29_RS07570 ENOG4105CNU cell division protein FtsK HRR29_RS07575 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HRR29_RS07580 ENOG4105D1H recombination factor protein RarA HRR29_RS07585 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HRR29_RS07590 ENOG4107QY8 reductase HRR29_RS07600 ENOG4107KGK dmso reductase anchor subunit HRR29_RS07605 ENOG4108ISG Major Facilitator HRR29_RS07615 ENOG4105F1A Pyruvate formate-lyase HRR29_RS07620 ENOG4105C6N Formate acetyltransferase HRR29_RS07625 ENOG4105TMB Formate nitrite transporter HRR29_RS07630 ENOG4105DDY UPF0142 protein ycaO HRR29_RS07635 ENOG4107VMU Membrane HRR29_RS07640 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HRR29_RS07645 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HRR29_RS07650 ENOG4105CAT Cytidine monophosphate kinase HRR29_RS07655 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HRR29_RS07660 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HRR29_RS07665 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HRR29_RS07670 ENOG4105BZ1 (ABC) transporter HRR29_RS07675 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HRR29_RS07680 ENOG4105T0Z Conserved Protein HRR29_RS07685 ENOG4105W49 UPF0434 protein HRR29_RS07690 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HRR29_RS07695 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HRR29_RS07700 ENOG4107S90 membrAne HRR29_RS07705 ENOG4106371 Methyltransferase HRR29_RS07715 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HRR29_RS07720 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HRR29_RS07725 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HRR29_RS07730 ENOG4105EAQ (twin-arginine translocation) pathway signal HRR29_RS07735 ENOG4105C5X domain protein HRR29_RS07740 ENOG4105CGF Aromatic amino acid aminotransferase HRR29_RS07745 ENOG4105FCK Membrane HRR29_RS07750 ENOG4105C5S asparaginyl-tRNA synthetase HRR29_RS07755 ENOG4107RH7 Nicotinate phosphoribosyltransferase HRR29_RS07760 ENOG4107R08 Integrase HRR29_RS07800 ENOG4108UUM single-stranded DNA-binding protein HRR29_RS07890 ENOG4105ZTP Protein of unknown function (DUF1376) HRR29_RS07940 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HRR29_RS07945 ENOG4108R1E Serine threonine protein phosphatase 1 HRR29_RS07955 ENOG4105QBX endodeoxyribonuclease RusA HRR29_RS07985 ENOG4106050 phage regulatory protein, rha family HRR29_RS08135 ENOG4105CD8 aminopeptidase N HRR29_RS08145 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HRR29_RS08150 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HRR29_RS08155 ENOG4105GVF (ABC) transporter HRR29_RS08160 ENOG4108UZX fmn reductase HRR29_RS08165 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HRR29_RS08170 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HRR29_RS08175 ENOG4105QVC MOSC domain-containing protein HRR29_RS08180 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HRR29_RS08185 ENOG4105C5H ABC transporter HRR29_RS08190 ENOG4105F1S paraquat-inducible protein a HRR29_RS08195 ENOG4105DY2 Paraquat-inducible protein b HRR29_RS08200 ENOG4108Q2G (LipO)protein HRR29_RS08205 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HRR29_RS08215 ENOG4105DAN ATP-dependent protease HRR29_RS08220 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HRR29_RS08225 ENOG4105UYK outer membrane protein a HRR29_RS08230 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HRR29_RS08235 ENOG4108RZ1 DNA transformation protein HRR29_RS08240 ENOG4105EM2 membrane HRR29_RS08245 ENOG410901E Membrane HRR29_RS08250 ENOG41088T4 Helicase IV HRR29_RS08255 ENOG4108Z5K methylglyoxal synthase HRR29_RS08260 ENOG4108Q67 UPF0319 protein HRR29_RS08265 ENOG4105K4P CoA-binding domain protein HRR29_RS08270 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HRR29_RS08275 ENOG4105DR4 Methyltransferase HRR29_RS08280 ENOG4108V1U phospholipid-binding protein HRR29_RS08290 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HRR29_RS08295 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HRR29_RS08335 ENOG4108MN8 Membrane HRR29_RS08340 ENOG4107QSI ABC, transporter HRR29_RS08370 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HRR29_RS08375 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HRR29_RS08400 ENOG41061H0 Monooxygenase HRR29_RS08405 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HRR29_RS08410 ENOG41084YZ Hydrolase HRR29_RS08415 ENOG4107QUY Guanine deaminase HRR29_RS08420 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HRR29_RS08455 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HRR29_RS08475 ENOG4105E5Q amino acid AbC transporter HRR29_RS08480 ENOG4105CDA abc transporter atp-binding protein HRR29_RS08485 ENOG4105C5R Aminotransferase HRR29_RS08495 ENOG4105CJW magnesium transporter HRR29_RS08500 ENOG4107T5V SNARE associated Golgi HRR29_RS08505 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HRR29_RS08525 ENOG4105D6F Phosphatase HRR29_RS08530 ENOG4105XH3 HRR29_RS08535 ENOG4105CS1 NAD(P)H quinone oxidoreductase HRR29_RS08540 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HRR29_RS08560 ENOG4105C2W permease HRR29_RS08565 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HRR29_RS08570 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HRR29_RS08575 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HRR29_RS08580 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) HRR29_RS08585 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HRR29_RS08590 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HRR29_RS08595 ENOG4108R86 Transcriptional regulator HRR29_RS08605 ENOG4105C26 Dehydrogenase HRR29_RS08610 ENOG4105CK7 Sodium proline symporter HRR29_RS08620 ENOG4105D9N nucleoside HRR29_RS08630 ENOG410650H (LipO)protein HRR29_RS08635 ENOG4105DBE peroxidase HRR29_RS08640 ENOG4105D5M phosphate starvation-inducible protein HRR29_RS08655 ENOG4105CHJ isochorismatase hydrolase HRR29_RS08660 ENOG4105EUB pirin domain protein HRR29_RS08665 ENOG4105CC0 LysR family Transcriptional regulator HRR29_RS08675 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HRR29_RS08680 ENOG4107SSZ Phosphatase HRR29_RS08685 ENOG4107XHZ cytoplasmic chaperone TorD family protein HRR29_RS08690 ENOG4108UQ5 membrane protein YcdZ HRR29_RS08695 ENOG4105P8Q Curli production assembly transport component CsgG HRR29_RS08700 ENOG4108WYR Curli production assembly transport component, CsgF HRR29_RS08705 ENOG4108XDW curli assembly protein CsgE HRR29_RS08710 ENOG41086KC Transcriptional regulator HRR29_RS08715 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HRR29_RS08720 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HRR29_RS08725 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HRR29_RS08735 ENOG4108UVJ appr-1-p processing domain protein HRR29_RS08750 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HRR29_RS08755 ENOG4105NAC (LipO)protein HRR29_RS08760 ENOG4108W47 Acidic protein msyB HRR29_RS08770 ENOG4105D1S lipid A biosynthesis HRR29_RS08775 ENOG4105C72 UPF0176 protein HRR29_RS08780 ENOG4108YYC ycei family HRR29_RS08785 ENOG4105DS1 cytochrome b561 HRR29_RS08790 ENOG4106974 biofilm formation HRR29_RS08795 ENOG4105F76 Sarcosine oxidase HRR29_RS08800 ENOG4105PVA Biofilm formation regulatory protein BssS HRR29_RS08805 ENOG4105MEA DNA damage-inducible protein i HRR29_RS08810 ENOG4105EKE dihydroorotase HRR29_RS08815 ENOG4105F3T (LipO)protein HRR29_RS08820 ENOG4105EV4 Multidrug resistance protein mdtH HRR29_RS08825 ENOG4105D9U N-acetyltransferase HRR29_RS08830 ENOG4108YXG UPF0502 protein HRR29_RS08835 ENOG4105EP9 oxidoreductase HRR29_RS08840 ENOG4105CJR Integral membrane protein (MviN HRR29_RS08845 ENOG4105QVD Flagella synthesis protein FlgN HRR29_RS08850 ENOG4105M9M anti-sigma28 factor FlgM HRR29_RS08855 ENOG4105CKS Flagella basal body P-ring formation protein flgA HRR29_RS08860 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HRR29_RS08865 ENOG4108ZC9 flagellar basal-body rod protein flgc HRR29_RS08870 ENOG4105W00 Flagellar hook capping protein HRR29_RS08875 ENOG4105BZE flagellar hook protein, FlgE HRR29_RS08880 ENOG4108KPB Flagellar basal-body rod protein FlgF HRR29_RS08885 ENOG4105CGA flagellar basal-body rod protein FlgG HRR29_RS08900 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HRR29_RS08905 ENOG4105E1Q flagellar hook-associated protein HRR29_RS08910 ENOG4105DTJ flagellar hook-associated protein HRR29_RS08915 ENOG4105EQ0 Major Facilitator superfamily HRR29_RS08920 ENOG4105EJC lysr family transcriptional regulator HRR29_RS08925 ENOG4107QQB Ribonuclease E HRR29_RS08930 ENOG4105EI2 Pseudouridine synthase HRR29_RS08935 ENOG4108UHJ MAF-like protein HRR29_RS08940 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HRR29_RS08945 ENOG4105VGS 50s ribosomal protein l32 HRR29_RS08950 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HRR29_RS08955 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HRR29_RS08960 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HRR29_RS08965 ENOG4105CHR reductase HRR29_RS08970 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HRR29_RS08975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HRR29_RS08980 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HRR29_RS08985 ENOG4105HHA aminodeoxychorismate lyase HRR29_RS08990 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HRR29_RS08995 ENOG4107QRG dna polymerase iii HRR29_RS09000 ENOG4105F8V Hydrolase, tatD family HRR29_RS09005 ENOG4105CI1 PTS System HRR29_RS09010 ENOG4105K59 histidine triad (HIT) protein HRR29_RS09015 ENOG41090DQ Lipoprotein HRR29_RS09020 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HRR29_RS09035 ENOG4105D0Y UPF0227 protein HRR29_RS09040 ENOG4105CEP NADH dehydrogenase HRR29_RS09045 ENOG4107MBR 17 kDa surface antigen HRR29_RS09050 ENOG4108IND Tetr family transcriptional regulator HRR29_RS09055 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HRR29_RS09060 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HRR29_RS09065 ENOG4108JA2 transcriptioN-repair coupling factor HRR29_RS09070 ENOG4105IQC Inner membrane protein YcfT HRR29_RS09075 ENOG4105D60 lipoprotein releasing system transmembrane protein HRR29_RS09080 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HRR29_RS09085 ENOG4105D60 lipoprotein releasing system transmembrane protein HRR29_RS09090 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HRR29_RS09095 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HRR29_RS09100 ENOG4105C8Q Methyl-accepting chemotaxis HRR29_RS09105 ENOG4105D58 Diguanylate phosphodiesterase HRR29_RS09110 ENOG4108HM4 ABC transporter HRR29_RS09115 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component HRR29_RS09125 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HRR29_RS09130 ENOG4105EQR Transposase IS116 IS110 IS902 HRR29_RS09140 ENOG4105EZE Cupin 4 family protein HRR29_RS09150 ENOG4105XJC Two component transcriptional regulator (Winged helix family HRR29_RS09155 ENOG4107QTF adenylosuccinate lyase HRR29_RS09160 ENOG41075W9 High frequency lysogenization protein HflD homolog HRR29_RS09175 ENOG4108R99 pseudouridine synthase HRR29_RS09180 ENOG4108HMX isocitrate dehydrogenase (NADP) HRR29_RS09190 ENOG4105N0E Protein of unknown function (DUF2543) HRR29_RS09200 ENOG4105BZU Histidine kinase HRR29_RS09210 ENOG4105Y3U Transglycosylase-associated protein HRR29_RS09215 ENOG4106G4W HRR29_RS09220 ENOG410620I Diguanylate cyclase HRR29_RS09225 ENOG4105UCG Domain of unknown function (DUF333) HRR29_RS09235 ENOG4105K78 MarR family Transcriptional regulator HRR29_RS09240 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HRR29_RS09245 ENOG4105DJ2 Major Facilitator Superfamily HRR29_RS09250 ENOG4105R1U AraC Family Transcriptional Regulator HRR29_RS09255 ENOG4108VMM UPF0756 membrane protein HRR29_RS09265 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HRR29_RS09270 ENOG4106AKX UPF0229 protein HRR29_RS09275 ENOG4105CYN Serine protein kinase HRR29_RS09280 ENOG4105GNX MltA-interacting MipA family protein HRR29_RS09285 ENOG4105DSB aldose 1-epimerase HRR29_RS09290 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HRR29_RS09300 ENOG4105VUT cytoplasmic protein HRR29_RS09305 ENOG4108RWI nicotinamidase HRR29_RS09310 ENOG4105HDK L-asparaginase HRR29_RS09315 ENOG4105D07 Signal peptide peptidase, SppA HRR29_RS09320 ENOG41069NU Nitroreductase HRR29_RS09325 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HRR29_RS09330 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HRR29_RS09335 ENOG4105D82 Glutamate dehydrogenase HRR29_RS09340 ENOG4105MTM Protein of unknown function (DUF1496) HRR29_RS09345 ENOG4105M6F mutator MutT protein HRR29_RS09350 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HRR29_RS09355 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HRR29_RS09360 ENOG4107RM6 sulfurtransferase HRR29_RS09365 ENOG4108VGW abc transporter atp-binding protein HRR29_RS09370 ENOG4105CXZ ABC transporter, permease HRR29_RS09375 ENOG4105VNH ABC transporter solute-binding protein HRR29_RS09385 ENOG4105CGK Exodeoxyribonuclease III HRR29_RS09390 ENOG4105C8Y Acetylornithine aminotransferase HRR29_RS09395 ENOG4105F4X arginine HRR29_RS09400 ENOG4105C26 Dehydrogenase HRR29_RS09405 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HRR29_RS09410 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HRR29_RS09415 ENOG4108SPG Periplasmic Protein HRR29_RS09420 ENOG41090B9 response to stress HRR29_RS09425 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HRR29_RS09430 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HRR29_RS09435 ENOG4105KKI DNA-binding transcriptional activator OsmE HRR29_RS09440 ENOG4105VZJ PTS System HRR29_RS09445 ENOG4105CK1 PTS System HRR29_RS09450 ENOG4105VCP PTS System HRR29_RS09455 ENOG4105EZV Transcriptional regulator HRR29_RS09460 ENOG4105F8D glycoside hydrolase family 4 HRR29_RS09465 ENOG410901P UPF0249 protein HRR29_RS09470 ENOG4105CH6 catalase HRR29_RS09480 ENOG4108ETY sodium dicarboxylate symporter HRR29_RS09485 ENOG4107K5X Membrane-bound metal-dependent hydrolase HRR29_RS09490 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HRR29_RS09495 ENOG4107PN8 YfeABCD locus regulator HRR29_RS09505 ENOG4105P10 Uncharacterized protein ydiZ HRR29_RS09510 ENOG4105DE4 1-phosphofructokinase HRR29_RS09515 ENOG4108NE3 Salt-induced outer membrane protein HRR29_RS09530 ENOG4105C22 threonyL-tRNA synthetase HRR29_RS09535 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HRR29_RS09540 ENOG41082NX 50s ribosomal protein l35 HRR29_RS09555 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HRR29_RS09560 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HRR29_RS09565 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HRR29_RS09575 ENOG4108V06 Glutathione peroxidase HRR29_RS09585 ENOG4108QBX (LipO)protein HRR29_RS09590 ENOG4108TC0 Diguanylate phosphodiesterase HRR29_RS09595 ENOG4105CNG UPF0061 protein HRR29_RS09600 ENOG4105DTD Dehydrogenase HRR29_RS09605 ENOG4105CY2 Citrate transporter HRR29_RS09610 ENOG4105CHU acetyl-coa acetyltransferase HRR29_RS09615 ENOG4107QNJ CoA-transferase subunit B HRR29_RS09620 ENOG4105D6N CoA-transferase, subunit a HRR29_RS09625 ENOG4106NZI LysR family Transcriptional regulator HRR29_RS09630 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HRR29_RS09635 ENOG4105EHG Permease protein HRR29_RS09640 ENOG4107R4I Periplasmic binding protein HRR29_RS09645 ENOG4106QJH hemin transport protein HRR29_RS09650 ENOG4107ENK receptor HRR29_RS09660 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HRR29_RS09665 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HRR29_RS09670 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HRR29_RS09675 ENOG4105CT4 transporter HRR29_RS09680 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HRR29_RS09690 ENOG4105IPI Membrane HRR29_RS09695 ENOG4105CQB FAD linked oxidase domain protein HRR29_RS09700 ENOG4105KA0 thioesterase Superfamily protein HRR29_RS09705 ENOG410671Z uncharacterized protein ydiH HRR29_RS09710 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HRR29_RS09725 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HRR29_RS09730 ENOG4105BZU Histidine kinase HRR29_RS09735 ENOG4108XDN Transcriptional regulator HRR29_RS09740 ENOG4108Z4V iron-sulfur cluster assembly HRR29_RS09745 ENOG4105DIW FeS assembly protein SUFB HRR29_RS09750 ENOG4105C3K feS assembly ATPase SufC HRR29_RS09755 ENOG4105JRK feS assembly protein SufD HRR29_RS09760 ENOG4105C9B Cysteine desulfurase HRR29_RS09765 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HRR29_RS09770 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HRR29_RS09780 ENOG4105CA9 Pyruvate kinase HRR29_RS09785 ENOG4105C28 cystathionine HRR29_RS09800 ENOG4108UMI ABC transporter, permease HRR29_RS09805 ENOG4105D01 (LipO)protein HRR29_RS09810 ENOG4105RFR Protein of unknown function (DUF2767) HRR29_RS09815 ENOG4105DRP amino acid AbC transporter HRR29_RS09820 ENOG4105E5Q amino acid AbC transporter HRR29_RS09830 ENOG4106TNF Periplasmic binding protein HRR29_RS09850 ENOG4107B2H carbonic anhydrase HRR29_RS09855 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HRR29_RS09870 ENOG4107QI1 Mate efflux family protein HRR29_RS09875 ENOG4108R6K riboflavin synthase, subunit alpha HRR29_RS09880 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HRR29_RS09885 ENOG4105CZQ inner membrane transport protein YdhC HRR29_RS09890 ENOG4105F52 Transcriptional regulator HRR29_RS09905 ENOG4105F27 Major Facilitator HRR29_RS09910 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HRR29_RS09915 ENOG4105K4H Nlp p60 protein HRR29_RS09920 ENOG4105M2J Glutaredoxin HRR29_RS09925 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HRR29_RS09930 ENOG4108UYE Lactoylglutathione lyase HRR29_RS09935 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HRR29_RS09940 ENOG4108WUH Transcriptional regulator, TetR family HRR29_RS09945 ENOG4105DIJ Phosphoethanolamine transferase HRR29_RS09950 ENOG4105XZD Fe-S protein HRR29_RS09955 ENOG4107RGM aldo keto reductase HRR29_RS09960 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HRR29_RS09965 ENOG4105DSW Fusaric acid resistance protein HRR29_RS09970 ENOG4105Y49 secretion protein, HlyD family HRR29_RS09985 ENOG4105BZU Histidine kinase HRR29_RS09990 ENOG4108XTF Outer Membrane Lipoprotein HRR29_RS09995 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HRR29_RS10000 ENOG410642K Lysozyme inhibitor HRR29_RS10005 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HRR29_RS10010 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HRR29_RS10015 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HRR29_RS10020 ENOG4108K3A Glutathione S-transferase HRR29_RS10025 ENOG4105DUX Transporter HRR29_RS10030 ENOG4105CSM endonuclease III HRR29_RS10040 ENOG4108UQQ Electron transport complex HRR29_RS10045 ENOG4105D6A Electron transport complex HRR29_RS10055 ENOG4108R3D Electron transport complex HRR29_RS10060 ENOG4105DGN Electron transport complex HRR29_RS10065 ENOG4105M9B inner membrane protein ydgK HRR29_RS10075 ENOG4106C6R beta-lactam resistance protein HRR29_RS10080 ENOG4105D9R oxidoreductase HRR29_RS10085 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HRR29_RS10090 ENOG4105C87 Aminotransferase class I and II HRR29_RS10095 ENOG4105CI1 PTS System HRR29_RS10100 ENOG4107P2S Transcriptional regulator HRR29_RS10105 ENOG4106J39 exported protein HRR29_RS10110 ENOG4105EIP mannose-6-phosphate isomerase HRR29_RS10115 ENOG4107GFK fumarate HRR29_RS10120 ENOG4105C9Q fumarate hydratase class II HRR29_RS10125 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HRR29_RS10130 ENOG4105JJR Histidine kinase HRR29_RS10140 ENOG4107EXC regulatoR HRR29_RS10145 ENOG4105RA2 Membrane HRR29_RS10150 ENOG410642E Short chain dehydrogenase HRR29_RS10155 ENOG4105D5Q Arginine ornithine antiporter HRR29_RS10160 ENOG4105C5D exported protein HRR29_RS10165 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HRR29_RS10170 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HRR29_RS10175 ENOG4105Q9Y Universal stress protein HRR29_RS10185 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HRR29_RS10190 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HRR29_RS10250 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HRR29_RS10255 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HRR29_RS10260 ENOG4105BZS acriflavin resistance protein HRR29_RS10270 ENOG41062D9 Histidine kinase HRR29_RS10285 ENOG4105N1F Hnh endonuclease HRR29_RS10295 ENOG4108M8W Monooxygenase HRR29_RS10300 ENOG4105DSF transport protein HRR29_RS10305 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HRR29_RS10320 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HRR29_RS10335 ENOG4105CTD carboxy-peptidase HRR29_RS10340 ENOG4105D94 Major Facilitator Superfamily HRR29_RS10345 ENOG4106NZI LysR family Transcriptional regulator HRR29_RS10350 ENOG4105DAG ROK family HRR29_RS10355 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HRR29_RS10360 ENOG4105CMQ Chloride channel HRR29_RS10365 ENOG4108IJ8 ABC transporter HRR29_RS10370 ENOG4105E90 ABC transporter HRR29_RS10375 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HRR29_RS10380 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component HRR29_RS10390 ENOG4108TGY Glutathione S-transferase HRR29_RS10405 ENOG4108PNB DNA-binding transcriptional regulator HRR29_RS10425 ENOG4105X2V dna damage-inducible protein HRR29_RS10430 ENOG4105UEI Transcriptional Regulator AraC Family HRR29_RS10435 ENOG4105C1P efflux transporter, rnd family, mfp subunit HRR29_RS10455 ENOG4105XJC Two component transcriptional regulator (Winged helix family HRR29_RS10480 ENOG4108NEM leader-binding protein dmsD HRR29_RS10485 ENOG4107QY8 reductase HRR29_RS10490 ENOG4105KBG Protein of unknown function (DUF1161) HRR29_RS10500 ENOG4108MK9 spermidine N(1)-acetyltransferase HRR29_RS10505 ENOG4105M5Q UPF0482 protein HRR29_RS10510 ENOG4105KK4 UPF0060 membrane protein HRR29_RS10515 ENOG4105CXK mandelate racemase muconate lactonizing HRR29_RS10520 ENOG4105CPQ Dehydrogenase HRR29_RS10530 ENOG4105DEI Mannitol dehydrogenase HRR29_RS10535 ENOG41061EV selenium-binding protein YdfZ HRR29_RS10540 ENOG4108U51 Universal stress protein HRR29_RS10545 ENOG4107XBN GntR Family Transcriptional Regulator HRR29_RS10550 ENOG4105EMU Dehydrogenase HRR29_RS10555 ENOG4105DGW oligopeptidase A HRR29_RS10560 ENOG4105BZU Histidine kinase HRR29_RS10565 ENOG4108RW8 Universal stress protein F HRR29_RS10580 ENOG4105C5I Dehydrogenase HRR29_RS10595 ENOG4107H52 Dicarboxylate transport HRR29_RS10600 ENOG410689M (LipO)protein HRR29_RS10605 ENOG4105WXT Conserved Protein HRR29_RS10610 ENOG4108WFR AraC Family Transcriptional Regulator HRR29_RS10615 ENOG4105C26 Dehydrogenase HRR29_RS10620 ENOG4105BZU Histidine kinase HRR29_RS10625 ENOG4105EUZ Beta-lactamase domain protein HRR29_RS10630 ENOG4105F11 amine oxidase HRR29_RS10635 ENOG4105DXM phenylacetic acid degradation protein HRR29_RS10640 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HRR29_RS10645 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HRR29_RS10650 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HRR29_RS10655 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HRR29_RS10660 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HRR29_RS10665 ENOG4105E39 Enoyl-CoA hydratase HRR29_RS10670 ENOG4108UKI Enoyl-CoA hydratase HRR29_RS10675 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HRR29_RS10680 ENOG4108ZJI phenylacetic acid degradation protein HRR29_RS10685 ENOG4105CHU acetyl-coa acetyltransferase HRR29_RS10690 ENOG4105DZS Phenylacetate-CoA ligase HRR29_RS10695 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HRR29_RS10700 ENOG4108Z0R Transferase HRR29_RS10705 ENOG4107R6D beta-lactam binding protein AmpH HRR29_RS10710 ENOG4108V06 Glutathione peroxidase HRR29_RS10725 ENOG4105DJ2 Major Facilitator Superfamily HRR29_RS10730 ENOG4108ZT1 Transcriptional regulator HRR29_RS10755 ENOG4108X0B nad(p)h dehydrogenase (quinone) HRR29_RS10780 ENOG4105EMU Dehydrogenase HRR29_RS10785 ENOG4105W1Y Transcriptional regulator HRR29_RS10800 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HRR29_RS10825 ENOG4105CHR reductase HRR29_RS10830 ENOG4105KVH Transcriptional regulator HRR29_RS10835 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HRR29_RS10860 ENOG4107FW0 short-chain dehydrogenase reductase HRR29_RS10875 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HRR29_RS10905 ENOG4105CMU LysR family (Transcriptional regulator HRR29_RS10910 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HRR29_RS10935 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HRR29_RS10940 ENOG4105D3G Pseudouridine synthase HRR29_RS10945 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HRR29_RS10950 ENOG4105CQ7 ATP-dependent helicase HRR29_RS10960 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HRR29_RS10975 ENOG4107DB1 DUF218 domain HRR29_RS10980 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HRR29_RS10985 ENOG4105CPW cytochrome b561 HRR29_RS10990 ENOG4105D9R oxidoreductase HRR29_RS10995 ENOG4105E98 transcriptional regulator DeoR family HRR29_RS11010 ENOG4108JJA ABC, transporter HRR29_RS11035 ENOG4105WPN DNA integration recombination invertion protein HRR29_RS11040 ENOG4105KD7 acetyltransferase HRR29_RS11045 ENOG4105W8I Transcriptional regulator HRR29_RS11050 ENOG4105F4I Transcriptional regulator HRR29_RS11070 ENOG4105F9N Major Facilitator Superfamily HRR29_RS11090 ENOG4105C8Q Methyl-accepting chemotaxis HRR29_RS11095 ENOG4105DZG Dehydrogenase HRR29_RS11100 ENOG4105DDW LysR family Transcriptional regulator HRR29_RS11105 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HRR29_RS11110 ENOG4108YDI single-species biofilm formation on inanimate substrate HRR29_RS11125 ENOG4108WTK competence damage-inducible protein HRR29_RS11135 ENOG4105CG3 alpha amylase, catalytic region HRR29_RS11140 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HRR29_RS11145 ENOG4105C4M (Ubiquinol oxidase) subunit I HRR29_RS11150 ENOG4105WEF catalase HRR29_RS11155 ENOG4108N8X transition metal ion binding HRR29_RS11165 ENOG4108Z9Z response to DNA damage stimulus HRR29_RS11175 ENOG4105E32 cytoplasmic protein HRR29_RS11180 ENOG4105EBR Carboxylesterase HRR29_RS11190 ENOG4105CHM Aminotransferase HRR29_RS11195 ENOG4105E89 ABC transporter HRR29_RS11200 ENOG4105DJ9 glucan biosynthesis protein HRR29_RS11205 ENOG4108Z9I -acetyltransferase HRR29_RS11210 ENOG4107WE3 acetyltransferase YdcK HRR29_RS11215 ENOG41088CC tellurite resistance protein tehB HRR29_RS11220 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HRR29_RS11225 ENOG4105DEF Extracellular solute-binding protein, family 5 HRR29_RS11230 ENOG4108KKZ (LipO)protein HRR29_RS11245 ENOG4105DKK Benzoate HRR29_RS11250 ENOG4108JCI Transcriptional regulator HRR29_RS11255 ENOG4105CFP Peptidase U32 HRR29_RS11260 ENOG4105RR0 Protein of unknown function (DUF2554) HRR29_RS11270 ENOG4105NAE bifunctional deaminase-reductase domain protein HRR29_RS11295 ENOG4105C32 Amino acid ABC transporter (Permease) HRR29_RS11300 ENOG4105CNN ABC, transporter HRR29_RS11305 ENOG4105C0Z ABC transporter HRR29_RS11310 ENOG4108IV0 ABC, transporter HRR29_RS11315 ENOG4108MEK Metal-binding protein YodA HRR29_RS11320 ENOG4105E5W Transporter HRR29_RS11325 ENOG4108594 Permease of the drug metabolite transporter HRR29_RS11330 ENOG4106DNR multiple antibiotic resistance protein HRR29_RS11335 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HRR29_RS11340 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HRR29_RS11345 ENOG41082NP Multiple antibiotic resistance HRR29_RS11350 ENOG4105F27 Major Facilitator HRR29_RS11355 ENOG4105JAB phenazine biosynthesis protein, phzf family HRR29_RS11360 ENOG4105JAB phenazine biosynthesis protein, phzf family HRR29_RS11370 ENOG4105EGI Transcriptional regulator HRR29_RS11375 ENOG4105C26 Dehydrogenase HRR29_RS11380 ENOG4105C8Q Methyl-accepting chemotaxis HRR29_RS11385 ENOG4105CSV Glutaminase HRR29_RS11390 ENOG4105M0C cytoplasmic protein HRR29_RS11395 ENOG4105BZU Histidine kinase HRR29_RS11400 ENOG4105BZU Histidine kinase HRR29_RS11410 ENOG4107QZW Altronate oxidoreductase HRR29_RS11415 ENOG4105FFC UPF0187 protein HRR29_RS11445 ENOG4105CPT Alpha beta hydrolase HRR29_RS11455 ENOG4105E0F Histidine kinase HRR29_RS11465 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HRR29_RS11475 ENOG4105VJY transcriptional regulator HRR29_RS11480 ENOG4107VIJ nudix hydrolase HRR29_RS11485 ENOG4105E98 transcriptional regulator DeoR family HRR29_RS11510 ENOG4105HEI LysR family (Transcriptional regulator HRR29_RS11570 ENOG4105EQR Transposase IS116 IS110 IS902 HRR29_RS11645 ENOG4105EQR Transposase IS116 IS110 IS902 HRR29_RS11695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HRR29_RS11710 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRR29_RS11745 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HRR29_RS11755 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HRR29_RS11770 ENOG4107RSM transcriptional regulator HRR29_RS11775 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HRR29_RS11830 ENOG4105BZU Histidine kinase HRR29_RS11840 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HRR29_RS11845 ENOG4105F32 YngK protein HRR29_RS11850 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HRR29_RS11860 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HRR29_RS11880 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HRR29_RS11885 ENOG4105C8Q Methyl-accepting chemotaxis HRR29_RS11890 ENOG4105WBN Transcriptional regulator (LacI family HRR29_RS11905 ENOG4108M0B Sucrose porin HRR29_RS11910 ENOG4105D7K pfkb domain protein HRR29_RS11915 ENOG4105BZU Histidine kinase HRR29_RS11930 ENOG4108UQS dipeptidase HRR29_RS11935 ENOG4105DEF Extracellular solute-binding protein, family 5 HRR29_RS11940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRR29_RS11945 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRR29_RS11950 ENOG4105C3U ABC transporter HRR29_RS11955 ENOG4107H6U ABC transporter HRR29_RS11960 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HRR29_RS11970 ENOG4108Z9K Osmotically inducible protein HRR29_RS11980 ENOG4105EXG Transcriptional regulator HRR29_RS11990 ENOG4105TPS biofilm-dependent modulation protein HRR29_RS12000 ENOG4107R1I NAD-dependent malic enzyme HRR29_RS12005 ENOG4105C5H ABC transporter HRR29_RS12010 ENOG4105DQ4 alcohol dehydrogenase HRR29_RS12025 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRR29_RS12030 ENOG4108JQ6 ABC transporter HRR29_RS12045 ENOG4105F27 Major Facilitator HRR29_RS12075 ENOG4108MG3 formate dehydrogenase HRR29_RS12080 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HRR29_RS12095 ENOG4105FCK Membrane HRR29_RS12100 ENOG4108MGI Transcriptional regulator HRR29_RS12105 ENOG4105C32 Amino acid ABC transporter (Permease) HRR29_RS12110 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HRR29_RS12115 ENOG4105C0Z ABC transporter HRR29_RS12120 ENOG4108IV0 ABC, transporter HRR29_RS12135 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HRR29_RS12140 ENOG4105DFH Transport of potassium into the cell (By similarity) HRR29_RS12155 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HRR29_RS12160 ENOG4108MEJ flavin reductase domain protein HRR29_RS12165 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HRR29_RS12170 ENOG4105YVS arsR family transcriptional regulator HRR29_RS12200 ENOG4107R1I NAD-dependent malic enzyme HRR29_RS12205 ENOG4105D1S lipid A biosynthesis HRR29_RS12210 ENOG4105KZK Tautomerase pptA HRR29_RS12215 ENOG4108N27 Glutathione S-transferase HRR29_RS12225 ENOG4105CDA abc transporter atp-binding protein HRR29_RS12230 ENOG4105E5Q amino acid AbC transporter HRR29_RS12240 ENOG4105EAB amino acid AbC transporter HRR29_RS12255 ENOG4105DEN Luciferase family HRR29_RS12260 ENOG4105CAT Cytidine monophosphate kinase HRR29_RS12265 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HRR29_RS12275 ENOG4105EQ2 LysR family Transcriptional regulator HRR29_RS12280 ENOG4105C85 amino acid HRR29_RS12285 ENOG4108NS2 receptor HRR29_RS12290 ENOG4105CHB tonB-dependent Receptor HRR29_RS12295 ENOG4108WYP Transcriptional regulator HRR29_RS12300 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HRR29_RS12310 ENOG4108Z7F N-acetyltransferase HRR29_RS12315 ENOG4108T9Y Inner membrane protein ydcZ HRR29_RS12320 ENOG4105R71 cytoplasmic protein HRR29_RS12325 ENOG4105DEF Extracellular solute-binding protein, family 5 HRR29_RS12345 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HRR29_RS12350 ENOG410654E Membrane HRR29_RS12355 ENOG4105C26 Dehydrogenase HRR29_RS12360 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HRR29_RS12365 ENOG4105D81 ABC transporter, permease HRR29_RS12370 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HRR29_RS12375 ENOG4107TYH extracellular solute-binding protein family 1 HRR29_RS12380 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HRR29_RS12390 ENOG4105C4M (Ubiquinol oxidase) subunit I HRR29_RS12395 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HRR29_RS12405 ENOG41090X5 Heat shock protein hslJ HRR29_RS12410 ENOG4105IKK cytoplasmic protein HRR29_RS12415 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HRR29_RS12420 ENOG4105FCK Membrane HRR29_RS12455 ENOG4105BZU Histidine kinase HRR29_RS12465 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HRR29_RS12470 ENOG4105C1J atp-dependent rna helicase HRR29_RS12480 ENOG4105C8Q Methyl-accepting chemotaxis HRR29_RS12485 ENOG4105BZU Histidine kinase HRR29_RS12490 ENOG4105BZU Histidine kinase HRR29_RS12500 ENOG4108Z0Z intracellular protease Pfpi family HRR29_RS12505 ENOG4107QSI ABC, transporter HRR29_RS12510 ENOG4105KXI murein peptide amidase A HRR29_RS12515 ENOG4107S8C mandelate racemase muconate lactonizing HRR29_RS12520 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HRR29_RS12530 ENOG4108JU8 Transcriptional regulator HRR29_RS12535 ENOG4106K28 UPF0283 membrane protein HRR29_RS12540 ENOG4105CM6 amino acid regulated cytosolic protein HRR29_RS12545 ENOG4105FKQ transcriptional regulator HRR29_RS12550 ENOG4107EFV Outer membrane protein G HRR29_RS12555 ENOG4108IJ9 (ABC) transporter HRR29_RS12560 ENOG4107URF beta-phospho-glucomutase HRR29_RS12565 ENOG4105C71 hydrolase family 65, central catalytic HRR29_RS12570 ENOG4105CK5 oxidoreductase HRR29_RS12575 ENOG4107TYA transient receptor potential locus HRR29_RS12580 ENOG4107RRD Dehydrogenase HRR29_RS12585 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HRR29_RS12590 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HRR29_RS12595 ENOG4105WEM extracellular solute-binding protein HRR29_RS12600 ENOG4107QW3 Sucrose phosphorylase HRR29_RS12605 ENOG4105NNG Peripheral inner membrane phage-shock protein HRR29_RS12610 ENOG4105FM1 phage shock protein C HRR29_RS12615 ENOG4105YYT phage shock protein B HRR29_RS12620 ENOG41087YS Phage shock protein A HRR29_RS12625 ENOG4105E51 psp operon transcriptional activator HRR29_RS12630 ENOG4108J59 Extracellular solute-binding protein, family 5 HRR29_RS12635 ENOG4108EKA peptide transport system, permease HRR29_RS12640 ENOG4108EU3 peptide transport system, permease HRR29_RS12645 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HRR29_RS12650 ENOG4108JQ2 peptide transport system atp-binding protein HRR29_RS12660 ENOG4105GR3 Histidine kinase HRR29_RS12665 ENOG4105E3W Two component transcriptional regulator (Winged helix family HRR29_RS12680 ENOG4105BZS acriflavin resistance protein HRR29_RS12685 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HRR29_RS12690 ENOG4105Q4T oxidoreductase HRR29_RS12695 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HRR29_RS12700 ENOG4105BZU Histidine kinase HRR29_RS12705 ENOG4105E39 Enoyl-CoA hydratase HRR29_RS12710 ENOG410643D UPF0509 protein HRR29_RS12715 ENOG4105N2W Transcriptional regulator HRR29_RS12720 ENOG41061RM osmotically inducible lipoprotein HRR29_RS12725 ENOG4108ZJT translation initiation factor, Sui1 HRR29_RS12730 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HRR29_RS12735 ENOG4105CFV Tetratricopeptide repeat protein HRR29_RS12740 ENOG4105Q4A inner membrane protein yciS HRR29_RS12745 ENOG4105EYK Phosphatidylglycerophosphatase B HRR29_RS12750 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HRR29_RS12755 ENOG4107QM5 aconitate hydratase HRR29_RS12770 ENOG4107R11 Transcriptional regulator HRR29_RS12775 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HRR29_RS12780 ENOG4105RKX Protein of unknown function (DUF2498) HRR29_RS12785 ENOG4105ERU peptidase HRR29_RS12790 ENOG4105UBK short-chain dehydrogenase reductase HRR29_RS12795 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HRR29_RS12800 ENOG4105FE9 pseudouridine synthase HRR29_RS12805 ENOG4107RTD sua5 ycio yrdc ywlc family protein HRR29_RS12810 ENOG4105DB7 PHP domain protein HRR29_RS12820 ENOG4105CRQ synthase (Component I) HRR29_RS12825 ENOG4108EFP Anthranilate synthase component II HRR29_RS12830 ENOG4105DK0 Indole-3-glycerol phosphate synthase HRR29_RS12835 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HRR29_RS12840 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HRR29_RS12845 ENOG41066VF YeeE YedE family protein HRR29_RS12860 ENOG4105EIF outer membrane protein W HRR29_RS12870 ENOG4105PI0 Ferredoxin HRR29_RS12875 ENOG4108S3I UPF0259 membrane protein HRR29_RS12880 ENOG4107835 probably involved in intracellular septation (By similarity) HRR29_RS12885 ENOG4105NAU thioesterase Superfamily protein HRR29_RS12890 ENOG410822N TonB family HRR29_RS12895 ENOG4105K9H YciI-like protein HRR29_RS12905 ENOG4108NIW Leucine export protein LeuE HRR29_RS12915 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HRR29_RS12920 ENOG4108W5H UPF0263 protein HRR29_RS12925 ENOG4105EYW Ion transport protein HRR29_RS12930 ENOG4108JQ7 (ABC) transporter HRR29_RS12935 ENOG4105C3U ABC transporter HRR29_RS12940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRR29_RS12945 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRR29_RS12950 ENOG4107QSI ABC, transporter HRR29_RS12955 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HRR29_RS12960 ENOG4105C0A alcohol dehydrogenase HRR29_RS12965 ENOG4107104 thymidine kinase HRR29_RS12975 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HRR29_RS12980 ENOG4105I93 response regulator HRR29_RS12985 ENOG4105D78 K07001 NTE family protein HRR29_RS12990 ENOG4105K5B UPF0225 protein HRR29_RS12995 ENOG4105CIY formyltetrahydrofolate deformylase HRR29_RS13020 ENOG41076YT nitrate reductase, gamma subunit HRR29_RS13025 ENOG4105R3A Nitrate reductase HRR29_RS13030 ENOG4108IUE nitrate reductase beta subunit HRR29_RS13035 ENOG4105CRU nitrate reductase, alpha subunit HRR29_RS13040 ENOG4105DQQ Major facilitator superfamily MFS_1 HRR29_RS13045 ENOG4105BZU Histidine kinase HRR29_RS13050 ENOG4105WH1 Two component transcriptional regulator luxr family HRR29_RS13055 ENOG4105ID0 Putative invasin HRR29_RS13065 ENOG4107QZF nitrite reductase NADPH large subunit HRR29_RS13070 ENOG4105D7T ABC transporter HRR29_RS13090 ENOG41090EX DsrE family HRR29_RS13095 ENOG4105C8Q Methyl-accepting chemotaxis HRR29_RS13105 ENOG4108NH8 Cation transport protein HRR29_RS13110 ENOG4105WS7 Cation transport regulator HRR29_RS13115 ENOG4105EWV Sodium calcium exchanger membrane region HRR29_RS13120 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HRR29_RS13125 ENOG41063JG Transcriptional regulator HRR29_RS13130 ENOG4108YY7 Invasion gene expression up-regulator SirB HRR29_RS13135 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HRR29_RS13145 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HRR29_RS13150 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HRR29_RS13155 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HRR29_RS13160 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HRR29_RS13165 ENOG4105CHH sulfate transporter HRR29_RS13175 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HRR29_RS13180 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HRR29_RS13185 ENOG4105C3G gtp-binding protein HRR29_RS13200 ENOG4105CNA YD repeat protein HRR29_RS13230 ENOG4105D9P serine threonine protein kinase HRR29_RS13235 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HRR29_RS13285 ENOG4108WC9 type VI secretion system effector, hcp1 family HRR29_RS13320 ENOG4106VK6 Flagellar motor protein HRR29_RS13340 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HRR29_RS13345 ENOG4105C5Q Transcriptional regulator HRR29_RS13370 ENOG4107RTG Major Facilitator superfamily HRR29_RS13380 ENOG4105E53 ec 3.2.1.28 HRR29_RS13385 ENOG4105E0K tonB-dependent siderophore receptor HRR29_RS13395 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HRR29_RS13400 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HRR29_RS13405 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HRR29_RS13410 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HRR29_RS13415 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HRR29_RS13420 ENOG4105MWK D-amino acid dehydrogenase, small subunit HRR29_RS13425 ENOG4105ED1 spovr family HRR29_RS13435 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HRR29_RS13440 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HRR29_RS13445 ENOG4108ZZ3 UPF0260 protein HRR29_RS13450 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HRR29_RS13455 ENOG4105VNG YcgL domain-containing protein HRR29_RS13460 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HRR29_RS13465 ENOG4107QMS site-determining protein HRR29_RS13470 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HRR29_RS13475 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HRR29_RS13480 ENOG4105CEY Amp-dependent synthetase and ligase HRR29_RS13485 ENOG4105Y4Z Outer Membrane Lipoprotein HRR29_RS13490 ENOG41072GX Peptidase M22 Glycoprotease HRR29_RS13495 ENOG4105DVT helicase HRR29_RS13500 ENOG4105M4H endoribonuclease L-psp HRR29_RS13510 ENOG4105CRQ synthase (Component I) HRR29_RS13520 ENOG4105EJQ L-serine dehydratase HRR29_RS13525 ENOG4107XTP (EAL) domain protein HRR29_RS13530 ENOG4105EE5 Membrane protein terC HRR29_RS13535 ENOG4105DAS pts system HRR29_RS13540 ENOG4105ETZ PTS System HRR29_RS13545 ENOG4105F3R pts system mannose fructose sorbose family iid HRR29_RS13550 ENOG4108NK4 UPF0266 membrane protein HRR29_RS13555 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HRR29_RS13560 ENOG4105DHI Methyltransferase HRR29_RS13565 ENOG4105CJN penicillin-binding protein HRR29_RS13585 ENOG4105Q3Y exported protein HRR29_RS13590 ENOG4106CCY Protein MgrB homolog HRR29_RS13595 ENOG4105TIK HRR29_RS13600 ENOG4105J4Q Transcriptional regulator HRR29_RS13605 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRR29_RS13610 ENOG4105D0M Protease HtpX homolog HRR29_RS13615 ENOG4105CN1 protease HRR29_RS13625 ENOG4108ZGC gaf domain protein HRR29_RS13630 ENOG4105H2K paraquat-inducible protein a HRR29_RS13635 ENOG4105DY2 Paraquat-inducible protein b HRR29_RS13640 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HRR29_RS13645 ENOG4105WT8 Protein of unknown function (DUF1480) HRR29_RS13650 ENOG4108R1E Serine threonine protein phosphatase 1 HRR29_RS13655 ENOG4108MJ5 VirK protein HRR29_RS13665 ENOG4105NKT exported protein HRR29_RS13670 ENOG4108PNC copper resistance HRR29_RS13675 ENOG4105FXM Copper resistance protein HRR29_RS13680 ENOG4105MPK DNA polymerase III subunit theta HRR29_RS13685 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HRR29_RS13690 ENOG4105UMD exodeoxyribonuclease X HRR29_RS13695 ENOG4105CUG Oligopeptidase b HRR29_RS13700 ENOG4108Q2J Inner membrane protein YebE HRR29_RS13705 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HRR29_RS13710 ENOG4108UHU Aldolase HRR29_RS13715 ENOG4105C01 Dihydroxy-acid dehydratase HRR29_RS13720 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HRR29_RS13725 ENOG4106KNT transcriptional regulator HRR29_RS13730 ENOG4105CA9 Pyruvate kinase HRR29_RS13735 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HRR29_RS13740 ENOG4105DR5 peptidase HRR29_RS13745 ENOG4105NXV High-affinity zinc uptake system protein HRR29_RS13755 ENOG4105FAV ABC, transporter HRR29_RS13760 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HRR29_RS13765 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HRR29_RS13770 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HRR29_RS13775 ENOG4105CDY transcriptional regulatory protein HRR29_RS13780 ENOG4108TIT dATP pyrophosphohydrolase HRR29_RS13785 ENOG4105C9M aspartyl-trna synthetase HRR29_RS13790 ENOG4105D3W isochorismatase HRR29_RS13795 ENOG41081XQ Conserved Protein HRR29_RS13800 ENOG4105WJG Glutathione HRR29_RS13805 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HRR29_RS13810 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HRR29_RS13815 ENOG4106N3A copper homeostasis protein cutc HRR29_RS13820 ENOG4106ZCM YecM protein HRR29_RS13825 ENOG4105C75 arginyL-tRNA synthetase HRR29_RS13830 ENOG4105F5H Glycosyl Hydrolase Family 88 HRR29_RS13835 ENOG4105CT4 transporter HRR29_RS13840 ENOG4105IRD Flagellar protein FlhE HRR29_RS13845 ENOG4105D7B Flagellar biosynthesis protein flha HRR29_RS13850 ENOG4105D00 flagellar biosynthetic protein flhB HRR29_RS13860 ENOG4108VCD Chaperone HRR29_RS13865 ENOG4105CW0 outer membrane usher protein HRR29_RS13875 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HRR29_RS13880 ENOG4108VYJ response regulator receiver protein HRR29_RS13885 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HRR29_RS13890 ENOG4105BZU Histidine kinase HRR29_RS13895 ENOG4105C8Q Methyl-accepting chemotaxis HRR29_RS13900 ENOG4105C8Q Methyl-accepting chemotaxis HRR29_RS13930 ENOG4107QJT sodium dicarboxylate symporter HRR29_RS13935 ENOG4108V3W Chemotaxis protein, CheW HRR29_RS13940 ENOG4105CBS Chea signal transduction histidine kinase HRR29_RS13945 ENOG4105ER2 Ompa motb domain protein HRR29_RS13950 ENOG4107RD7 Flagellar Motor Protein, MotA HRR29_RS13955 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HRR29_RS13960 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HRR29_RS13965 ENOG4108VA4 Universal stress protein HRR29_RS13970 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HRR29_RS13975 ENOG4108K4C ec 3.1.3.12 HRR29_RS13980 ENOG4105CNN ABC, transporter HRR29_RS13990 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HRR29_RS13995 ENOG4108UEC Ferritin-like protein HRR29_RS14000 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HRR29_RS14005 ENOG4105N4N Protein of unknown function (DUF2766) HRR29_RS14020 ENOG41090A1 ferritin HRR29_RS14030 ENOG4105E0U tyrosine-specific transport protein HRR29_RS14035 ENOG4106RHG Yeca family HRR29_RS14045 ENOG4105C32 Amino acid ABC transporter (Permease) HRR29_RS14050 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HRR29_RS14055 ENOG4105C0Z ABC transporter HRR29_RS14060 ENOG4108IV0 ABC, transporter HRR29_RS14090 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HRR29_RS14095 ENOG4105WH1 Two component transcriptional regulator luxr family HRR29_RS14100 ENOG4105XVG cytoplasmic protein HRR29_RS14105 ENOG4105VJY transcriptional regulator HRR29_RS14110 ENOG4105CDA abc transporter atp-binding protein HRR29_RS14115 ENOG4105E5Q amino acid AbC transporter HRR29_RS14125 ENOG4105EAB amino acid AbC transporter HRR29_RS14130 ENOG4108M9K flagella biosynthesis protein FliZ HRR29_RS14135 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRR29_RS14155 ENOG4105MQ3 flagellar protein FliS HRR29_RS14160 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HRR29_RS14165 ENOG4105E5K Alpha-amylase HRR29_RS14170 ENOG4108W9D (LipO)protein HRR29_RS14210 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HRR29_RS14215 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HRR29_RS14220 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HRR29_RS14225 ENOG41090PJ Flagellar assembly protein HRR29_RS14230 ENOG4108JIR Flagellum-specific ATP synthase HRR29_RS14235 ENOG4105GSA Flagellar export protein flij HRR29_RS14240 ENOG4105WF4 Flagellar hook-length control protein HRR29_RS14245 ENOG4107ZI8 flagellar basal body-associated protein flil HRR29_RS14250 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HRR29_RS14255 ENOG4105DD5 Flagellar motor switch protein HRR29_RS14260 ENOG4105K0P flagellar biosynthesis protein HRR29_RS14265 ENOG4105CN7 Flagellar biosynthetic protein FliP HRR29_RS14275 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HRR29_RS14280 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HRR29_RS14290 ENOG4105YX3 cellular response to acidity HRR29_RS14305 ENOG4105VNZ cytoplasmic protein HRR29_RS14310 ENOG4105CKW Inner membrane protein yedI HRR29_RS14315 ENOG4105FDR Membrane HRR29_RS14320 ENOG41090BB DNA mismatch endonuclease (vsr) HRR29_RS14325 ENOG4105DVF Cytosine-specific methyltransferase HRR29_RS14330 ENOG4105EST Metal Dependent Phosphohydrolase HRR29_RS14335 ENOG4105FCK Membrane HRR29_RS14345 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HRR29_RS14350 ENOG4108MRH transcriptional regulatory protein HRR29_RS14370 ENOG4107GFK fumarate HRR29_RS14375 ENOG4105CSH Transporter HRR29_RS14385 ENOG4105F04 LysR family Transcriptional regulator HRR29_RS14390 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein HRR29_RS14420 ENOG4105DUU IucA IucC family protein HRR29_RS14425 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HRR29_RS14445 ENOG4105SUT Transcriptional Regulator AraC Family HRR29_RS14450 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HRR29_RS14455 ENOG4105CCU oxidase (Subunit III) HRR29_RS14460 ENOG4105BZ9 Cytochrome C oxidase, subunit I HRR29_RS14465 ENOG4105E2S oxidase) subunit II HRR29_RS14470 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRR29_RS14475 ENOG4105CW7 secretion protein, HlyD family HRR29_RS14505 ENOG4105KSC Transcriptional regulator, TraR DksA family HRR29_RS14525 ENOG4105EJX conjugal transfer ATPase HRR29_RS14555 ENOG4108PCE TRANSFER protein HRR29_RS14565 ENOG4108EHY type IV secretion system HRR29_RS14580 ENOG4105EQR Transposase IS116 IS110 IS902 HRR29_RS14660 ENOG4108UQ8 endoribonuclease L-psp HRR29_RS14675 ENOG4105XUP Phage derived protein Gp49-like (DUF891) HRR29_RS14680 ENOG4105ETT transcriptional Regulator, LysR family HRR29_RS14690 ENOG4107R11 Transcriptional regulator HRR29_RS14705 ENOG4108PXI ErfK YbiS YcfS YnhG HRR29_RS14715 ENOG4108U51 Universal stress protein HRR29_RS14725 ENOG4105BZS acriflavin resistance protein HRR29_RS14740 ENOG4105CSH Transporter HRR29_RS14745 ENOG4105FYV Amp nucleosidase HRR29_RS14750 ENOG4105DC7 peptidase M24 HRR29_RS14760 ENOG4105UQX Mate efflux family protein HRR29_RS14780 ENOG4105DR8 Membrane HRR29_RS14785 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) HRR29_RS14790 ENOG4105DZ1 carboxypeptidase HRR29_RS14795 ENOG4105CJB Exodeoxyribonuclease I HRR29_RS14800 ENOG4105CUB amino acid HRR29_RS14810 ENOG4105EQ1 Transcriptional regulator HRR29_RS14815 ENOG4107SRH Nad-dependent epimerase dehydratase HRR29_RS14825 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HRR29_RS14835 ENOG4105CIH Imidazole acetol-phosphate transaminase HRR29_RS14840 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HRR29_RS14845 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HRR29_RS14850 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HRR29_RS14855 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HRR29_RS14865 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HRR29_RS14890 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HRR29_RS14900 ENOG4108RT7 Glycosyl transferase, family 2 HRR29_RS14935 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HRR29_RS14945 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HRR29_RS14950 ENOG4105C1B dTDP-glucose 4-6-dehydratase HRR29_RS14955 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HRR29_RS14960 ENOG4105G1A colanic acid biosynthesis protein HRR29_RS14965 ENOG4107T8Q Glycosyl transferase (Group 1 HRR29_RS14970 ENOG4105C74 pyruvyl transferase HRR29_RS14975 ENOG4105PSV Polysaccharide Biosynthesis Protein HRR29_RS14980 ENOG4105D3Q Sugar transferase HRR29_RS14985 ENOG4107QKV phosphomannomutase HRR29_RS14990 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HRR29_RS14995 ENOG4106CD9 glycosyl transferase group 1 HRR29_RS15000 ENOG4105FGF GDP-mannose mannosyl hydrolase HRR29_RS15005 ENOG4105C30 Nad-dependent epimerase dehydratase HRR29_RS15010 ENOG4105C0K Gdp-mannose 4,6-dehydratase HRR29_RS15015 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HRR29_RS15020 ENOG4105ECJ Glycosyl Transferase HRR29_RS15025 ENOG4108NYJ Colanic acid HRR29_RS15030 ENOG4107RXY Glycosyl transferase HRR29_RS15035 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HRR29_RS15040 ENOG41090RK glycosyl transferase HRR29_RS15045 ENOG4105D75 Capsular exopolysaccharide family HRR29_RS15050 ENOG4105KJF protein tyrosine phosphatase HRR29_RS15055 ENOG4105DAY polysaccharide export protein HRR29_RS15060 ENOG4105EE5 Membrane protein terC HRR29_RS15065 ENOG4108GAE asmA family HRR29_RS15070 ENOG4105DHP deoxycytidine triphosphate deaminase HRR29_RS15080 ENOG4105BZU Histidine kinase HRR29_RS15085 ENOG4105D03 DNA-3-methyladenine glycosylase II HRR29_RS15090 ENOG4105R8A Heat shock protein HRR29_RS15095 ENOG4105ENT Efflux transporter rnd family, mfp subunit HRR29_RS15100 ENOG4105BZS acriflavin resistance protein HRR29_RS15105 ENOG4105BZS acriflavin resistance protein HRR29_RS15110 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRR29_RS15115 ENOG4105EB3 Histidine kinase HRR29_RS15120 ENOG4105E3W Two component transcriptional regulator (Winged helix family HRR29_RS15130 ENOG4105CFP Peptidase U32 HRR29_RS15135 ENOG4105EWC Purine nucleoside phosphorylase HRR29_RS15140 ENOG4107TE5 Lipid kinase HRR29_RS15145 ENOG4105EIE fructose-bisphosphate aldolase HRR29_RS15150 ENOG4105EAA nucleoside HRR29_RS15155 ENOG4108KD5 ADP-ribosylation crystallin J1 HRR29_RS15160 ENOG4108TFM Kinase, PfkB family HRR29_RS15165 ENOG4105FDP GntR family transcriptional regulator HRR29_RS15170 ENOG4105DWF phosphomethylpyrimidine kinase HRR29_RS15175 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HRR29_RS15195 ENOG4108JPW Aminotransferase HRR29_RS15200 ENOG4105DY8 decarboxylase HRR29_RS15205 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HRR29_RS15210 ENOG4105D75 Capsular exopolysaccharide family HRR29_RS15215 ENOG4107ZF2 Phosphatase HRR29_RS15220 ENOG4105DAY polysaccharide export protein HRR29_RS15225 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HRR29_RS15235 ENOG4105D1F ATP-binding protein HRR29_RS15240 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HRR29_RS15245 ENOG4108W15 Protein of unknown function (DUF1456) HRR29_RS15250 ENOG4108NEV two component transcriptional regulator, LytTR family HRR29_RS15255 ENOG4108HRK Histidine kinase HRR29_RS15260 ENOG4108XDN Transcriptional regulator HRR29_RS15270 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HRR29_RS15275 ENOG4108IJ8 ABC transporter HRR29_RS15280 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HRR29_RS15285 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HRR29_RS15290 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HRR29_RS15295 ENOG4105CXG d-lactate dehydrogenase HRR29_RS15305 ENOG41061WM D-Alanyl-D-Alanine HRR29_RS15310 ENOG41069YE inner membrane protein yohC HRR29_RS15315 ENOG4105KHU inner membrane protein YohD HRR29_RS15320 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HRR29_RS15330 ENOG4105CS2 ec 3.2.1.21 HRR29_RS15345 ENOG4105TW1 Carbohydrate-selective porin OprB HRR29_RS15350 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HRR29_RS15355 ENOG4105R1U AraC Family Transcriptional Regulator HRR29_RS15360 ENOG41089BK Glutamine amido-transferase HRR29_RS15365 ENOG4105VAW lrga family HRR29_RS15370 ENOG41067MG lrgb family HRR29_RS15375 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HRR29_RS15380 ENOG4107GZ4 SanA protein HRR29_RS15385 ENOG4105CFQ glutamine synthetase HRR29_RS15390 ENOG4107SDZ Galactoside transport system permease protein mglC HRR29_RS15395 ENOG4105C2J ABC transporter HRR29_RS15405 ENOG41060NJ transcriptional regulator HRR29_RS15410 ENOG4105DHF Membrane HRR29_RS15415 ENOG4105EUJ GTP cyclohydrolase i HRR29_RS15420 ENOG4105CBP Major Facilitator HRR29_RS15430 ENOG4105D05 Receptor HRR29_RS15435 ENOG4108IQI permease HRR29_RS15440 ENOG4105DUM transcriptional regulator, lysR family HRR29_RS15445 ENOG4105HMI Membrane HRR29_RS15450 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HRR29_RS15455 ENOG4105DM4 PTS System HRR29_RS15460 ENOG4105DE4 1-phosphofructokinase HRR29_RS15465 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HRR29_RS15475 ENOG4105K4U addiction module toxin, RelE StbE family HRR29_RS15505 ENOG4105KRS Proteinase inhibitor HRR29_RS15510 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HRR29_RS15515 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HRR29_RS15520 ENOG4105DEI Mannitol dehydrogenase HRR29_RS15525 ENOG4105CKI cobalamin synthesis protein HRR29_RS15530 ENOG41076MN Phosphoesterase, PA-phosphatase related HRR29_RS15535 ENOG4107TT5 NLP P60 protein HRR29_RS15540 ENOG4105CXC rtn protein HRR29_RS15545 ENOG4105E43 Extracellular solute-binding protein, family 5 HRR29_RS15550 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HRR29_RS15555 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HRR29_RS15560 ENOG4108JQ5 ABC transporter HRR29_RS15565 ENOG4105HG6 HRR29_RS15570 ENOG4105C2C drug resistance transporter, Bcr CflA HRR29_RS15575 ENOG4105I08 Pseudouridine synthase HRR29_RS15580 ENOG4105CFI type iii restriction protein res subunit HRR29_RS15585 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HRR29_RS15590 ENOG4106V8H Nucleoid-associated protein HRR29_RS15595 ENOG4105PAN UPF0352 protein HRR29_RS15600 ENOG4105E68 Sulfatase HRR29_RS15615 ENOG4105S5I Membrane HRR29_RS15625 ENOG4105DWT malate dehydrogenase (quinone) HRR29_RS15630 ENOG4105CHH sulfate transporter HRR29_RS15635 ENOG4105CJW magnesium transporter HRR29_RS15640 ENOG4105IBP Cyclic peptide transporter HRR29_RS15645 ENOG4105CF1 Alkylated DNA repair protein HRR29_RS15650 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HRR29_RS15660 ENOG4105FCK Membrane HRR29_RS15665 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HRR29_RS15670 ENOG41068CG regulatoR HRR29_RS15675 ENOG4105BZU Histidine kinase HRR29_RS15680 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRR29_RS15685 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HRR29_RS15690 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HRR29_RS15695 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HRR29_RS15700 ENOG4105XPH Ferredoxin HRR29_RS15705 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HRR29_RS15710 ENOG4105CXY transporter HRR29_RS15715 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HRR29_RS15720 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HRR29_RS15725 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HRR29_RS15730 ENOG4108EWA cinA-like protein HRR29_RS15735 ENOG4108UII YfaZ family HRR29_RS15740 ENOG4105CEY Amp-dependent synthetase and ligase HRR29_RS15745 ENOG4105DNI Converts SHCHC to OSB (By similarity) HRR29_RS15750 ENOG4108IPT Naphthoate synthase HRR29_RS15755 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HRR29_RS15760 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HRR29_RS15765 ENOG4105E4F Isochorismate synthase HRR29_RS15770 ENOG4105TNS Conserved Protein HRR29_RS15775 ENOG4107YB6 acetyltransferase, (GNAT) family HRR29_RS15780 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HRR29_RS15790 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRR29_RS15795 ENOG4105C8S subunit m HRR29_RS15800 ENOG4105D65 subunit l HRR29_RS15805 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRR29_RS15810 ENOG4107UFS subunit j HRR29_RS15820 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HRR29_RS15825 ENOG4108IEH NADH dehydrogenase subunit g HRR29_RS15830 ENOG4107QIZ NADH dehydrogenase HRR29_RS15835 ENOG4105GKE subunit e HRR29_RS15840 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRR29_RS15845 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRR29_RS15850 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HRR29_RS15855 ENOG4107NQ8 LysR family Transcriptional regulator HRR29_RS15860 ENOG4105CHM Aminotransferase HRR29_RS15865 ENOG4105DK2 UPF0207 protein HRR29_RS15870 ENOG4107QWE )-transporter HRR29_RS15875 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HRR29_RS15880 ENOG4105XWI UPF0304 protein HRR29_RS15890 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HRR29_RS15895 ENOG4105C6K Malic enzyme HRR29_RS15900 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HRR29_RS15905 ENOG4108HHA Transketolase HRR29_RS15910 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HRR29_RS15920 ENOG4106ETB IIa component HRR29_RS15925 ENOG4105K2J Transcriptional regulator HRR29_RS15930 ENOG4105PTV Nudix Hydrolase HRR29_RS15935 ENOG4108RE9 Phosphodiesterase HRR29_RS15940 ENOG4108SHQ Glutathione S-transferase HRR29_RS15945 ENOG4105CYM Glutathione S-transferase HRR29_RS15950 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HRR29_RS15955 ENOG4105ECP epimerase HRR29_RS15960 ENOG4105D9U N-acetyltransferase HRR29_RS15965 ENOG4108JEH abc transporter atp-binding protein HRR29_RS15970 ENOG4106YG3 ABC transporter HRR29_RS15975 ENOG4105DSP amino acid AbC transporter HRR29_RS15980 ENOG4105E89 ABC transporter HRR29_RS15985 ENOG4105E89 ABC transporter HRR29_RS15990 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HRR29_RS15995 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HRR29_RS16000 ENOG4105E96 Colicin v production protein HRR29_RS16005 ENOG4108S3P Sporulation domain protein HRR29_RS16010 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HRR29_RS16015 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HRR29_RS16020 ENOG4105DQR SNARE associated Golgi HRR29_RS16025 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HRR29_RS16030 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HRR29_RS16035 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HRR29_RS16040 ENOG4106WZ1 flagella biosynthesis regulator HRR29_RS16045 ENOG4105F9N Major Facilitator Superfamily HRR29_RS16050 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HRR29_RS16055 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HRR29_RS16060 ENOG4105MH2 YfcL protein HRR29_RS16065 ENOG4108BPE -transporting atpase HRR29_RS16070 ENOG4105EJ9 Membrane HRR29_RS16075 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HRR29_RS16080 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HRR29_RS16085 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HRR29_RS16090 ENOG4108DG9 Smr protein MutS2 HRR29_RS16095 ENOG4108BY2 phosphohistidine phosphatase HRR29_RS16100 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HRR29_RS16105 ENOG4105CHU acetyl-coa acetyltransferase HRR29_RS16110 ENOG4105KZW UPF0381 protein HRR29_RS16115 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HRR29_RS16120 ENOG410903C (LipO)protein HRR29_RS16125 ENOG4105S64 Formate nitrite transporter HRR29_RS16135 ENOG4105DFP Integrase HRR29_RS16265 ENOG4105CS6 Rhs element vgr protein HRR29_RS16275 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HRR29_RS16285 ENOG4108ZG0 Ompa motb domain protein HRR29_RS16315 ENOG4105D1S lipid A biosynthesis HRR29_RS16325 ENOG4105CHM Aminotransferase HRR29_RS16330 ENOG4108HRK Histidine kinase HRR29_RS16335 ENOG4105DY9 regulatoR HRR29_RS16340 ENOG4105CHC glucokinase (EC 2.7.1.2) HRR29_RS16350 ENOG4107RA9 decarboxylase HRR29_RS16355 ENOG4105CPC Aldo Keto reductase HRR29_RS16360 ENOG4109076 Conserved Protein HRR29_RS16365 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HRR29_RS16370 ENOG4105D9N nucleoside HRR29_RS16375 ENOG4108KMM Diguanylate cyclase HRR29_RS16390 ENOG4105HZG regulatoR HRR29_RS16395 ENOG4105GXM Putative transcription regulator (DUF1323) HRR29_RS16400 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HRR29_RS16430 ENOG4108M0I Transcriptional regulator HRR29_RS16435 ENOG4105DHU Bile acid HRR29_RS16440 ENOG4105VRT cytoplasmic protein HRR29_RS16445 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HRR29_RS16450 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HRR29_RS16455 ENOG4105EXN Sulfate transport protein CysZ HRR29_RS16460 ENOG4105C6T cysteine synthase HRR29_RS16470 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HRR29_RS16475 ENOG4105C5Y PTS System HRR29_RS16480 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HRR29_RS16485 ENOG4105C6T cysteine synthase HRR29_RS16490 ENOG4108IJ6 ABC transporter HRR29_RS16495 ENOG4105ECW sulfate abc transporter HRR29_RS16500 ENOG4108I5D sulfate abc transporter HRR29_RS16505 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HRR29_RS16510 ENOG4105EZR dyp-type peroxidase family protein HRR29_RS16515 ENOG4105E7K (LipO)protein HRR29_RS16520 ENOG4105QZU Inner membrane protein YfeZ HRR29_RS16525 ENOG4108R6G acetyltransferase HRR29_RS16530 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HRR29_RS16535 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HRR29_RS16540 ENOG4105C6K Malic enzyme HRR29_RS16550 ENOG4105CV1 Transketolase (EC 2.2.1.1) HRR29_RS16555 ENOG4108PVD exported protein HRR29_RS16560 ENOG4107VIJ nudix hydrolase HRR29_RS16565 ENOG4105BZ8 glutamate synthase HRR29_RS16570 ENOG4105BZU Histidine kinase HRR29_RS16575 ENOG4105BZS acriflavin resistance protein HRR29_RS16585 ENOG4105KUZ arsenate reductase HRR29_RS16590 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HRR29_RS16600 ENOG4106KED esterase YpfH HRR29_RS16605 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HRR29_RS16610 ENOG4105CGZ zinc metallopeptidase HRR29_RS16615 ENOG4105C8V SAICAR synthetase HRR29_RS16620 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HRR29_RS16630 ENOG4105RH4 Glycine cleavage system transcriptional repressor HRR29_RS16635 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HRR29_RS16640 ENOG4105C02 permease HRR29_RS16645 ENOG4105ERG peptidase m48, ste24p HRR29_RS16650 ENOG4105K89 arsenate reductase HRR29_RS16670 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HRR29_RS16675 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HRR29_RS16680 ENOG4105C2W permease HRR29_RS16685 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HRR29_RS16690 ENOG4105CS2 ec 3.2.1.21 HRR29_RS16700 ENOG4108V3E phosphoribosylglycinamide formyltransferase HRR29_RS16710 ENOG4105C9X ppx gppa phosphatase HRR29_RS16715 ENOG4105BZU Histidine kinase HRR29_RS16720 ENOG41062G3 Protein of unknown function (DUF2633) HRR29_RS16725 ENOG4105DUM transcriptional regulator, lysR family HRR29_RS16755 ENOG4105DH8 myo-inositol catabolism HRR29_RS16765 ENOG4105D7K pfkb domain protein HRR29_RS16775 ENOG4105CNN ABC, transporter HRR29_RS16785 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HRR29_RS16795 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HRR29_RS16800 ENOG4105C26 Dehydrogenase HRR29_RS16830 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HRR29_RS16835 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HRR29_RS16840 ENOG4105D4Y metalloprotease HRR29_RS16850 ENOG4105VPD cellular component movement HRR29_RS16855 ENOG4105DUX Transporter HRR29_RS16860 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HRR29_RS16865 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HRR29_RS16870 ENOG4105N21 Membrane HRR29_RS16875 ENOG4105CUT histidyl-tRNA synthetase HRR29_RS16890 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HRR29_RS16895 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HRR29_RS16900 ENOG4108JQB penicillin-binding protein 1C HRR29_RS16905 ENOG4105DN3 alpha-2-macroglobulin domain protein HRR29_RS16910 ENOG4105CI1 PTS System HRR29_RS16920 ENOG4105KHC sulfurtransferase HRR29_RS16925 ENOG4108Q3X Transcriptional regulator HRR29_RS16930 ENOG4105YYA enhanced serine sensitivity protein SseB HRR29_RS16935 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HRR29_RS16940 ENOG4105WVQ Fe-S assembly protein IscX HRR29_RS16945 ENOG4108ZIT Ferredoxin, 2FE-2S HRR29_RS16950 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HRR29_RS16955 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HRR29_RS16960 ENOG4108Z4V iron-sulfur cluster assembly HRR29_RS16965 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HRR29_RS16970 ENOG4105C3J Cysteine desulfurase HRR29_RS16975 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HRR29_RS16980 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HRR29_RS16985 ENOG4105ECY inositol monophosphatase HRR29_RS16990 ENOG4105D7X high-affinity nickel-transporter HRR29_RS17000 ENOG4108MN2 Stationary phase inducible protein CsiE HRR29_RS17005 ENOG4105D8G Major Facilitator superfamily HRR29_RS17010 ENOG4108SB3 DoxX Family HRR29_RS17015 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HRR29_RS17020 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HRR29_RS17025 ENOG4108YZA Nitrogen regulatory protein pii HRR29_RS17030 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HRR29_RS17035 ENOG4108SKK alpha helix protein HRR29_RS17040 ENOG4107WP9 Histidine kinase HRR29_RS17045 ENOG4108ETH Formylglycinamide ribotide synthetase HRR29_RS17050 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HRR29_RS17055 ENOG4108Z6B deaminase HRR29_RS17060 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HRR29_RS17070 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HRR29_RS17075 ENOG4106G6Q Transcriptional regulator HRR29_RS17080 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HRR29_RS17085 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HRR29_RS17090 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HRR29_RS17095 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HRR29_RS17105 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HRR29_RS17110 ENOG4105C3F Signal peptidase i HRR29_RS17115 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HRR29_RS17120 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HRR29_RS17130 ENOG41069PW sigma-e factor negative regulatory protein HRR29_RS17145 ENOG4108IYU L-aspartate oxidase HRR29_RS17150 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HRR29_RS17155 ENOG4105C1J atp-dependent rna helicase HRR29_RS17160 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HRR29_RS17170 ENOG4105EIB trna rrna methyltransferase HRR29_RS17175 ENOG4105K63 Thioredoxin HRR29_RS17180 ENOG4106IUH DTW domain containing protein HRR29_RS17185 ENOG4105CD5 CoA-binding domain protein HRR29_RS17190 ENOG4105JIM Phosphatidylserine synthase HRR29_RS17195 ENOG4105T42 (LipO)protein HRR29_RS17200 ENOG4105CSH Transporter HRR29_RS17225 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HRR29_RS17230 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HRR29_RS17235 ENOG4105C34 Pseudouridine synthase HRR29_RS17240 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HRR29_RS17245 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HRR29_RS17255 ENOG4105CQC Prephenate dehydratase HRR29_RS17265 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HRR29_RS17270 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HRR29_RS17280 ENOG4108WS1 HRR29_RS17285 ENOG4108KHX Diguanylate cyclase HRR29_RS17290 ENOG41090EK ompa motb domain protein HRR29_RS17305 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HRR29_RS17310 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HRR29_RS17315 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HRR29_RS17320 ENOG4105K5M 30s ribosomal protein S16 HRR29_RS17325 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HRR29_RS17330 ENOG4106KVJ cytochrome C assembly protein HRR29_RS17335 ENOG4108JU6 CBS domain protein HRR29_RS17340 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HRR29_RS17345 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HRR29_RS17350 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HRR29_RS17355 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HRR29_RS17360 ENOG4105VDB UPF0125 protein HRR29_RS17365 ENOG4108Z1B Cyclase dehydrase HRR29_RS17380 ENOG4105Y50 Virulence Protein HRR29_RS17390 ENOG4105PTU response to oxidative stress HRR29_RS17515 ENOG4108N0N Phage Terminase Large Subunit HRR29_RS17525 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) HRR29_RS17555 ENOG4105NVB glycoside hydrolase, family 19 HRR29_RS17620 ENOG4108XTP Transcriptional regulator HRR29_RS17655 ENOG4107R08 Integrase HRR29_RS17670 ENOG4105DFP Integrase HRR29_RS17690 ENOG4105ZTC transcriptional activator, Ogr delta HRR29_RS17720 ENOG4105I6B RNA polymerase HRR29_RS17750 ENOG41080ET plasmid maintenance system killer protein HRR29_RS17755 ENOG41081XE plasmid maintenance system antidote protein, xre family HRR29_RS17760 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) HRR29_RS17780 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HRR29_RS17785 ENOG4105HEI LysR family (Transcriptional regulator HRR29_RS17795 ENOG4105DMQ Methyltransferase HRR29_RS17800 ENOG4105DZC cytosine deaminase HRR29_RS17805 ENOG4105C5B carbamate kinase HRR29_RS17815 ENOG4107REC cytoplasmic protein HRR29_RS17820 ENOG4107R1Q Membrane protein FdrA HRR29_RS17825 ENOG4107SNB ankyrin repeat protein YahD HRR29_RS17830 ENOG4108NUU Transcriptional regulator HRR29_RS17835 ENOG4105VPI YqaE family transport protein HRR29_RS17840 ENOG41080HT Transcriptional regulator, arsr family HRR29_RS17845 ENOG4108V62 Rhodanese domain protein HRR29_RS17855 ENOG4108X73 DNA- binding protein HRR29_RS17860 ENOG4108RNS Exports L-alanine (By similarity) HRR29_RS17865 ENOG4108WMJ Protein of unknown function (DUF2002) HRR29_RS17870 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HRR29_RS17875 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HRR29_RS17880 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HRR29_RS17885 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HRR29_RS17890 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HRR29_RS17895 ENOG4108IJ7 Glycine betaine HRR29_RS17900 ENOG4108HQS Glycine betaine HRR29_RS17905 ENOG4105GIJ Glycine betaine HRR29_RS17915 ENOG4105NTK Transcriptional repressor Mpra HRR29_RS17920 ENOG4105CW7 secretion protein, HlyD family HRR29_RS17925 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRR29_RS17930 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HRR29_RS17940 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HRR29_RS17945 ENOG4105D9M gamma-glutamylcysteine synthetase HRR29_RS17950 ENOG4105W39 Membrane HRR29_RS17955 ENOG4107VXZ Hydrolase HRR29_RS17985 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HRR29_RS17990 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HRR29_RS18000 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HRR29_RS18005 ENOG4107TH8 cina domain protein HRR29_RS18015 ENOG4105CC5 ABC transporter HRR29_RS18020 ENOG4105DIK (ABC) transporter HRR29_RS18025 ENOG4105CVE Lytic murein transglycosylase HRR29_RS18030 ENOG410787A Pts system, glucitol sorbitol-specific HRR29_RS18035 ENOG4105DZY Pts system, glucitol sorbitol-specific HRR29_RS18040 ENOG4105VI0 Pts system, glucitol sorbitol-specific HRR29_RS18045 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HRR29_RS18050 ENOG4105J92 DNA-binding transcriptional activator GutM HRR29_RS18055 ENOG410804X Transcriptional regulator HRR29_RS18065 ENOG4108JUA Transcriptional regulator HRR29_RS18070 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center HRR29_RS18075 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HRR29_RS18085 ENOG4105C8H hydrogenase maturation protein Hypf HRR29_RS18090 ENOG4108RC0 Electron transport protein HRR29_RS18095 ENOG4105DDV Transcriptional regulator (LacI family HRR29_RS18100 ENOG4105C5Y PTS System HRR29_RS18105 ENOG4105CS2 ec 3.2.1.21 HRR29_RS18110 ENOG4108MG9 hydrogenase 3 maturation protease HRR29_RS18115 ENOG4105I6X formate hydrogenlyase maturation HRR29_RS18120 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HRR29_RS18125 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HRR29_RS18130 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRR29_RS18135 ENOG4107TDF Formate hydrogenlyase subunit 4 HRR29_RS18140 ENOG4107R30 NADH dehydrogenase HRR29_RS18145 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HRR29_RS18150 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HRR29_RS18155 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HRR29_RS18160 ENOG4107RSS Hydrogenase accessory protein HypB HRR29_RS18165 ENOG41083WG hydrogenase assembly chaperone HRR29_RS18170 ENOG4105CQS hydrogenase expression formation protein HypD HRR29_RS18175 ENOG4105C45 hydrogenase expression formation protein (HypE) HRR29_RS18190 ENOG4105EHG Permease protein HRR29_RS18195 ENOG4105E0A ABC, transporter HRR29_RS18205 ENOG4105VXR cytoplasmic protein HRR29_RS18215 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HRR29_RS18220 ENOG4105KZM cytoplasmic protein HRR29_RS18225 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HRR29_RS18230 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HRR29_RS18240 ENOG4105JQN Transcriptional regulator HRR29_RS18245 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRR29_RS18260 ENOG4108K5P (LipO)protein HRR29_RS18265 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HRR29_RS18270 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HRR29_RS18275 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HRR29_RS18285 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HRR29_RS18290 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HRR29_RS18295 ENOG4105N0Z inner membrane protein ygbE HRR29_RS18300 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) HRR29_RS18305 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HRR29_RS18310 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HRR29_RS18315 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HRR29_RS18320 ENOG4108MXK alkaline phosphatase isozyme conversion HRR29_RS18325 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HRR29_RS18335 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HRR29_RS18340 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HRR29_RS18345 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HRR29_RS18350 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HRR29_RS18355 ENOG4105CI1 PTS System HRR29_RS18370 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HRR29_RS18375 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HRR29_RS18380 ENOG4105DXN mazG family HRR29_RS18385 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HRR29_RS18390 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HRR29_RS18395 ENOG4105BZU Histidine kinase HRR29_RS18400 ENOG4105BZW Glycerate kinase HRR29_RS18405 ENOG4105EQX glucarate dehydratase HRR29_RS18410 ENOG4105EQX glucarate dehydratase HRR29_RS18415 ENOG4105DJB Major Facilitator Superfamily HRR29_RS18420 ENOG4105QDK Flavodoxin HRR29_RS18425 ENOG4105DR9 pseudouridine synthase HRR29_RS18430 ENOG4105WP7 tRNA pseudouridine synthase C HRR29_RS18435 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HRR29_RS18445 ENOG4105EWT decarboxylase family HRR29_RS18450 ENOG4105C44 Serine transporter HRR29_RS18455 ENOG4105EJQ L-serine dehydratase HRR29_RS18460 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HRR29_RS18465 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HRR29_RS18470 ENOG4105M08 Membrane HRR29_RS18475 ENOG4105ETT transcriptional Regulator, LysR family HRR29_RS18480 ENOG4105M5B (LipO)protein HRR29_RS18485 ENOG4105C9B Cysteine desulfurase HRR29_RS18490 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HRR29_RS18495 ENOG4105CUZ uba thif-type nad fad binding protein HRR29_RS18500 ENOG4105CA3 membrane-bound lytic murein transglycosylase HRR29_RS18520 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HRR29_RS18525 ENOG4107QZM n-acetylglutamate synthase HRR29_RS18530 ENOG4107QYX exodeoxyribonuclease v alpha HRR29_RS18535 ENOG4107QKA exodeoxyribonuclease V beta HRR29_RS18540 ENOG4107QXK peptidase HRR29_RS18545 ENOG4105DSY exodeoxyribonuclease V, gamma HRR29_RS18550 ENOG4105RVB Prepilin peptidase dependent protein c HRR29_RS18555 ENOG4105SEN Protein of unknown function (DUF2509) HRR29_RS18560 ENOG4105JCS prepilin peptidase dependent protein HRR29_RS18565 ENOG4105IPU prepilin peptidase dependent protein A HRR29_RS18570 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HRR29_RS18575 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HRR29_RS18580 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HRR29_RS18585 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HRR29_RS18590 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HRR29_RS18595 ENOG4105SUV lipoprotein YgdR HRR29_RS18600 ENOG4105CPC Aldo Keto reductase HRR29_RS18605 ENOG4107S74 Lysophospholipid transporter LplT HRR29_RS18610 ENOG4105CEY Amp-dependent synthetase and ligase HRR29_RS18615 ENOG41060NJ transcriptional regulator HRR29_RS18625 ENOG4105DDV Transcriptional regulator (LacI family HRR29_RS18635 ENOG4105RQF LysR family Transcriptional regulator HRR29_RS18645 ENOG4108QY5 Ferric enterobactin transport protein HRR29_RS18650 ENOG4107QNK )-transporter HRR29_RS18655 ENOG4105CHR reductase HRR29_RS18665 ENOG4105CHU acetyl-coa acetyltransferase HRR29_RS18680 ENOG4108MHD transport protein HRR29_RS18685 ENOG4105EW9 transcriptional regulator AsnC family HRR29_RS18695 ENOG410830R acetyltransferase HRR29_RS18700 ENOG4105VR1 Pfam:DUF1271 HRR29_RS18705 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HRR29_RS18710 ENOG4106YYS transcriptional regulatory protein HRR29_RS18725 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HRR29_RS18740 ENOG4105D5K Hemolysin activator protein HRR29_RS18750 ENOG4108K5P (LipO)protein HRR29_RS18755 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HRR29_RS18760 ENOG4105CRK lysyL-tRNA synthetase HRR29_RS18770 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HRR29_RS18775 ENOG4105T95 Thiol disulfide interChange protein HRR29_RS18780 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HRR29_RS18785 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HRR29_RS18790 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HRR29_RS18795 ENOG4105Y75 tpr repeat protein HRR29_RS18800 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HRR29_RS18805 ENOG4108UT2 hemolysin iii HRR29_RS18815 ENOG4108Q3X Transcriptional regulator HRR29_RS18820 ENOG4105CS2 ec 3.2.1.21 HRR29_RS18825 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HRR29_RS18830 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HRR29_RS18840 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HRR29_RS18845 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HRR29_RS18850 ENOG4105D0A hydroxylase HRR29_RS18855 ENOG4107RAQ aminopeptidase HRR29_RS18865 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HRR29_RS18875 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HRR29_RS18880 ENOG4108JQ1 Dehydrogenase HRR29_RS18885 ENOG4105E66 phosphoriboisomerase A HRR29_RS18890 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HRR29_RS18895 ENOG4105MPN Membrane HRR29_RS18900 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HRR29_RS18905 ENOG4105D64 Mechanosensitive ion channel HRR29_RS18910 ENOG4105D2N Aldolase HRR29_RS18920 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HRR29_RS18925 ENOG4105CV1 Transketolase (EC 2.2.1.1) HRR29_RS18930 ENOG4108K0D peptidase, M48 HRR29_RS18935 ENOG4105J5J Outer membrane porin HRR29_RS18940 ENOG4105CYW agmatinase HRR29_RS18945 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HRR29_RS18960 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HRR29_RS19010 ENOG4107QNK )-transporter HRR29_RS19015 ENOG4105GPY SprT protein HRR29_RS19020 ENOG4105RWS endonuclease I HRR29_RS19025 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HRR29_RS19030 ENOG4105D7Z glutathione synthase HRR29_RS19035 ENOG4108UJU UPF0301 protein HRR29_RS19040 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HRR29_RS19045 ENOG4105CZX twitching motility protein HRR29_RS19050 ENOG4105DFA alanine racemase domain protein HRR29_RS19055 ENOG4108VIA integral membrane protein HRR29_RS19060 ENOG4105VZ9 UPF0235 protein HRR29_RS19070 ENOG4105CSA Coproporphyrinogen iii oxidase HRR29_RS19075 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HRR29_RS19080 ENOG4105K33 Periplasmic Protein HRR29_RS19085 ENOG41090ED Protein with unknown function (DUF469) HRR29_RS19095 ENOG4105CEN a g-specific adenine glycosylase HRR29_RS19100 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HRR29_RS19105 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HRR29_RS19110 ENOG4105EAA nucleoside HRR29_RS19115 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HRR29_RS19125 ENOG4105CHY citrate lyase, alpha HRR29_RS19130 ENOG4105CI0 Citrate lyase HRR29_RS19135 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HRR29_RS19140 ENOG4105DUA (citrate (pro-3S)-lyase ligase HRR29_RS19145 ENOG4105ERH Fumarylacetoacetate hydrolase HRR29_RS19150 ENOG4105D2K citrate carrier protein HRR29_RS19155 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HRR29_RS19160 ENOG4106YYS transcriptional regulatory protein HRR29_RS19165 ENOG4105CXN decarboxylase HRR29_RS19170 ENOG4108UQV Membrane HRR29_RS19185 ENOG4108TUY outer membrane protein PgaA HRR29_RS19190 ENOG4107BJW polysaccharide deacetylase HRR29_RS19195 ENOG4105CND Glycosyl transferase, family 2 HRR29_RS19205 ENOG4106032 Glutathionylspermidine synthase HRR29_RS19210 ENOG4108JQ7 (ABC) transporter HRR29_RS19215 ENOG4105C3U ABC transporter HRR29_RS19220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRR29_RS19235 ENOG4105CYM Glutathione S-transferase HRR29_RS19270 ENOG4108TEB UPF0114 protein HRR29_RS19290 ENOG4108ZZF transport protein (ExbD) HRR29_RS19295 ENOG4105CWK Biopolymer transport protein, ExbB HRR29_RS19300 ENOG4105C28 cystathionine HRR29_RS19305 ENOG4108K81 inner membrane protein YghB HRR29_RS19310 ENOG4105CF7 AraC family transcriptional regulator HRR29_RS19315 ENOG4108I6A alcohol dehydrogenase HRR29_RS19320 ENOG4105CV8 reductase HRR29_RS19385 ENOG4107QN2 dihydrolipoyl dehydrogenase HRR29_RS19395 ENOG4108SF5 RNA Polymerase HRR29_RS19400 ENOG4108S3W Anti-feci sigma factor, fecr HRR29_RS19405 ENOG4105GAV receptor HRR29_RS19410 ENOG4108HUF Transporter HRR29_RS19415 ENOG4105DQ5 transport system permease protein HRR29_RS19420 ENOG4108IHU transport system permease protein HRR29_RS19425 ENOG4105E0A ABC, transporter HRR29_RS19430 ENOG4108YXQ IS66 Orf2 family protein HRR29_RS19445 ENOG4105EQR Transposase IS116 IS110 IS902 HRR29_RS19450 ENOG4105ETE Transcriptional regulator (LacI family HRR29_RS19460 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HRR29_RS19475 ENOG4105E2A Dehydrogenase HRR29_RS19485 ENOG4105EKQ RNA-directed DNA polymerase HRR29_RS19525 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HRR29_RS19530 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HRR29_RS19535 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HRR29_RS19540 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRR29_RS19545 ENOG4105H4F exported protein HRR29_RS19550 ENOG4105XJC Two component transcriptional regulator (Winged helix family HRR29_RS19555 ENOG4105DHQ Histidine kinase HRR29_RS19560 ENOG4105NF4 modulator of drug activity HRR29_RS19565 ENOG4105VRH Antibiotic biosynthesis monooxygenase HRR29_RS19580 ENOG4105EHG Permease protein HRR29_RS19585 ENOG4105DQ5 transport system permease protein HRR29_RS19590 ENOG4105E0A ABC, transporter HRR29_RS19600 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRR29_RS19605 ENOG4105IPS esterase HRR29_RS19610 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HRR29_RS19615 ENOG4108SX3 cytoplasmic protein HRR29_RS19620 ENOG41087AY ADP-Ribose pyrophosphatase HRR29_RS19630 ENOG4105F1G UPF0441 protein HRR29_RS19635 ENOG4106032 Glutathionylspermidine synthase HRR29_RS19640 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HRR29_RS19650 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HRR29_RS19655 ENOG4105W0Z cytoplasmic protein HRR29_RS19660 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HRR29_RS19665 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HRR29_RS19670 ENOG4105I7R Adenylate cyclase HRR29_RS19675 ENOG4106MWK domain protein HRR29_RS19680 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HRR29_RS19685 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HRR29_RS19690 ENOG4107ZVW dihydroneopterin aldolase HRR29_RS19695 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HRR29_RS19700 ENOG4105C54 Major Facilitator superfamily HRR29_RS19705 ENOG4105K56 Transcriptional regulator HRR29_RS19715 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HRR29_RS19720 ENOG4108YZ9 Urea amidohydrolase subunit gamma HRR29_RS19725 ENOG4105KI2 Urea amidohydrolase subunit beta HRR29_RS19730 ENOG4105CQM Urea amidohydrolase subunit alpha HRR29_RS19735 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HRR29_RS19745 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HRR29_RS19750 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HRR29_RS19755 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HRR29_RS19765 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HRR29_RS19770 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRR29_RS19775 ENOG4108VCA G U mismatch-specific DNA glycosylase HRR29_RS19785 ENOG4105ZTC transcriptional activator, Ogr delta HRR29_RS19825 ENOG4108C33 Resolvase HRR29_RS19840 ENOG4108US3 tail fiber assembly HRR29_RS19900 ENOG4105VZ1 Replication Protein HRR29_RS19905 ENOG4105KSC Transcriptional regulator, TraR DksA family HRR29_RS19930 ENOG4105Q26 Siderophore-interacting protein HRR29_RS19935 ENOG4105NTW Transcriptional regulator HRR29_RS19940 ENOG4105C8Q Methyl-accepting chemotaxis HRR29_RS19945 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HRR29_RS19950 ENOG4105C8Y Acetylornithine aminotransferase HRR29_RS19970 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HRR29_RS19975 ENOG41061GT Aldolase HRR29_RS19980 ENOG4105D4B ABC, transporter HRR29_RS19985 ENOG4105F5R ABC transporter HRR29_RS19990 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HRR29_RS19995 ENOG4105C2J ABC transporter HRR29_RS20000 ENOG4105DKT Transcriptional regulator HRR29_RS20005 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HRR29_RS20010 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HRR29_RS20015 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HRR29_RS20020 ENOG4108VKG metal-dependent hydrolase HRR29_RS20025 ENOG4105EE0 oxidoreductase HRR29_RS20030 ENOG4105DU1 integral membrane protein, terc HRR29_RS20040 ENOG4105CTX dehydratase HRR29_RS20050 ENOG4105DPW Major facilitator superfamily MFS_1 HRR29_RS20055 ENOG4107YCY Transcriptional regulator HRR29_RS20060 ENOG4106W5V Membrane HRR29_RS20065 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HRR29_RS20070 ENOG4105WAY exported protein HRR29_RS20075 ENOG4105NE1 Conserved Protein HRR29_RS20080 ENOG41090KG Inner membrane protein YqjE HRR29_RS20085 ENOG4105YJD HRR29_RS20090 ENOG4108VBZ doxx family HRR29_RS20095 ENOG4105CHF Glutathione S-transferase HRR29_RS20100 ENOG4105KAF membrAne HRR29_RS20105 ENOG4105CWB LysR family transcriptional Regulator HRR29_RS20110 ENOG4108CNN domain protein HRR29_RS20120 ENOG4105C6N Formate acetyltransferase HRR29_RS20125 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HRR29_RS20130 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HRR29_RS20135 ENOG4105C7B Threonine dehydratase HRR29_RS20140 ENOG410811B TRANSCRIPTIONal HRR29_RS20150 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HRR29_RS20155 ENOG4105CNV Aldolase HRR29_RS20160 ENOG4105CTX dehydratase HRR29_RS20165 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HRR29_RS20170 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HRR29_RS20175 ENOG41082RQ UPF0102 protein HRR29_RS20180 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HRR29_RS20185 ENOG4105W4M Transport-associated protein HRR29_RS20190 ENOG4107S21 permease HRR29_RS20195 ENOG4105K4T epimerase HRR29_RS20200 ENOG4107R7Y intracellular protease Pfpi family HRR29_RS20205 ENOG4108ZPB UPF0306 protein HRR29_RS20210 ENOG41082IR Excinuclease ABC C subunit domain protein HRR29_RS20215 ENOG4108YYD acetyltransferase HRR29_RS20235 ENOG4105DEN Luciferase family HRR29_RS20240 ENOG4105CIC tryptophan-specific transport protein HRR29_RS20245 ENOG4105C1J atp-dependent rna helicase HRR29_RS20260 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HRR29_RS20265 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HRR29_RS20270 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HRR29_RS20275 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HRR29_RS20280 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HRR29_RS20285 ENOG4105CHV Transcription elongation factor NusA HRR29_RS20290 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HRR29_RS20300 ENOG4105CDH Citrulline--aspartate ligase HRR29_RS20310 ENOG4105NTZ Preprotein translocase subunit SecG HRR29_RS20315 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HRR29_RS20320 ENOG4105EEI dihydropteroate synthase HRR29_RS20325 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HRR29_RS20330 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HRR29_RS20335 ENOG4105HBR Rna-binding protein HRR29_RS20340 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HRR29_RS20345 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HRR29_RS20360 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HRR29_RS20365 ENOG4105QYV Membrane HRR29_RS20370 ENOG4105K46 50S ribosomal protein l27 HRR29_RS20375 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HRR29_RS20380 ENOG4105EAH synthase HRR29_RS20385 ENOG4105HVQ Regulatory factor of maltose metabolism HRR29_RS20390 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HRR29_RS20395 ENOG4105VFK BolA family HRR29_RS20400 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HRR29_RS20405 ENOG4105E3I toluene tolerance HRR29_RS20410 ENOG4107PE3 Mammalian cell entry related domain protein HRR29_RS20415 ENOG4105CY3 ABC transporter, permease HRR29_RS20420 ENOG4105DHJ ABC, transporter HRR29_RS20425 ENOG4105FEU K -dependent Na -Ca exchanger HRR29_RS20430 ENOG4105C2X Arabinose 5-phosphate isomerase HRR29_RS20435 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HRR29_RS20440 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HRR29_RS20445 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HRR29_RS20450 ENOG4108IUZ ABC transporter HRR29_RS20455 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRR29_RS20460 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HRR29_RS20465 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HRR29_RS20470 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HRR29_RS20475 ENOG41080Z8 PHOSPHOCARRIER protein HRR29_RS20480 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HRR29_RS20485 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HRR29_RS20490 ENOG4105BZU Histidine kinase HRR29_RS20495 ENOG4108K5H permease YjgP YjgQ family protein HRR29_RS20500 ENOG4108M8S permease YjgP YjgQ family protein HRR29_RS20505 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HRR29_RS20510 ENOG4105MYG DNA polymerase iii, chi subunit HRR29_RS20520 ENOG4108MJ3 acetyltransferase HRR29_RS20525 ENOG4105DQ4 alcohol dehydrogenase HRR29_RS20535 ENOG4105D7A ATP-binding protein HRR29_RS20540 ENOG4105N5T Radical SAM Protein HRR29_RS20545 ENOG4105CBC glutamate synthase HRR29_RS20550 ENOG4105BZ8 glutamate synthase HRR29_RS20555 ENOG4105KB2 stringent starvation protein b HRR29_RS20560 ENOG4107MKT Stringent starvation protein a HRR29_RS20565 ENOG4108UJD 30S ribosomal protein S9 HRR29_RS20575 ENOG4105D6Z AFG1 family ATPase HRR29_RS20580 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HRR29_RS20585 ENOG4105C0H protease HRR29_RS20590 ENOG4105C0H protease HRR29_RS20595 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HRR29_RS20600 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HRR29_RS20605 ENOG4105RID UPF0379 protein yhcN HRR29_RS20610 ENOG4105RID UPF0379 protein yhcN HRR29_RS20615 ENOG4105UNR (Barnase) inhibitor HRR29_RS20620 ENOG4105C26 Dehydrogenase HRR29_RS20625 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HRR29_RS20635 ENOG4105ZQC membrane protein AaeX HRR29_RS20640 ENOG4105CR8 Transcriptional regulator HRR29_RS20645 ENOG4105D1U peptidase U62 modulator of DNA gyrase HRR29_RS20650 ENOG4105QD6 exported protein HRR29_RS20655 ENOG4105C03 ribonuclease HRR29_RS20665 ENOG4105VQ7 Rod shape-determining protein MreD HRR29_RS20670 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HRR29_RS20680 ENOG41062P1 Diguanylate cyclase phosphodiesterase HRR29_RS20685 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HRR29_RS20690 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HRR29_RS20695 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HRR29_RS20700 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HRR29_RS20705 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HRR29_RS20710 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HRR29_RS20715 ENOG4105RG0 Membrane HRR29_RS20720 ENOG4108IA2 Sodium pantothenate symporter HRR29_RS20725 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HRR29_RS20735 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HRR29_RS20745 ENOG41061ME transport protein HRR29_RS20750 ENOG4105BZU Histidine kinase HRR29_RS20755 ENOG4108XG4 DNA-binding transcriptional regulator HRR29_RS20760 ENOG4105C1P efflux transporter, rnd family, mfp subunit HRR29_RS20765 ENOG4105BZS acriflavin resistance protein HRR29_RS20770 ENOG4105XCM membrane LIPOPROTEIN HRR29_RS20780 ENOG4105EZ7 amino acid ABC transporter HRR29_RS20785 ENOG4105DRP amino acid AbC transporter HRR29_RS20790 ENOG4105CDA abc transporter atp-binding protein HRR29_RS20820 ENOG4108Z0R Transferase HRR29_RS20825 ENOG4105SG3 Protein of unknown function (DUF1488) HRR29_RS20830 ENOG4105E2X shikimate dehydrogenase HRR29_RS20835 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HRR29_RS20840 ENOG4108WI1 Dna topoisomerase HRR29_RS20845 ENOG4108RPN Protein smg homolog HRR29_RS20850 ENOG4105C79 DNA protecting protein DprA HRR29_RS20855 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HRR29_RS20860 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HRR29_RS20865 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HRR29_RS20870 ENOG4105C1A potassium transporter peripheral membrane HRR29_RS20875 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HRR29_RS20880 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HRR29_RS20885 ENOG4105W1Y Transcriptional regulator HRR29_RS20890 ENOG4105VTS DnaJ-like, subfamily C HRR29_RS20900 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HRR29_RS20905 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HRR29_RS20910 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HRR29_RS20920 ENOG41067V7 50S ribosomal protein L36 HRR29_RS20925 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HRR29_RS20935 ENOG4105VPB 50S ribosomal protein L30 HRR29_RS20950 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HRR29_RS20955 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HRR29_RS20960 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HRR29_RS20970 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HRR29_RS20975 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HRR29_RS20980 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HRR29_RS20985 ENOG41083MP 50s ribosomal protein l29 HRR29_RS20990 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HRR29_RS21000 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HRR29_RS21040 ENOG4108UQY Iron-storage protein HRR29_RS21045 ENOG4105W53 bacterioferritin-associated ferredoxin HRR29_RS21050 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HRR29_RS21055 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HRR29_RS21070 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HRR29_RS21075 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HRR29_RS21080 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HRR29_RS21085 ENOG4105WWK YheO domain protein HRR29_RS21090 ENOG4108V1T peptidylprolyl cis-trans isomerase HRR29_RS21100 ENOG4108YZY peptidylprolyl cis-trans isomerase HRR29_RS21105 ENOG4105VKU nucleicacid-binding protein HRR29_RS21110 ENOG4105CKD glutathione-regulated potassium-efflux system protein HRR29_RS21115 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HRR29_RS21120 ENOG4105C5H ABC transporter HRR29_RS21125 ENOG4105DNZ Alpha Beta Hydrolase HRR29_RS21130 ENOG4105YP7 UPF0270 protein HRR29_RS21135 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HRR29_RS21140 ENOG4108UKZ OsmC family HRR29_RS21145 ENOG4107RYR Transcriptional regulator, Crp Fnr family HRR29_RS21150 ENOG410613R integral membrane protein, YccS YhfK family HRR29_RS21155 ENOG4105C8Y Acetylornithine aminotransferase HRR29_RS21160 ENOG4105DDQ anthranilate synthase HRR29_RS21165 ENOG4105MZU cell filamentation protein HRR29_RS21170 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HRR29_RS21175 ENOG4106DTQ Protein TsgA homolog HRR29_RS21180 ENOG4105DZC cytosine deaminase HRR29_RS21185 ENOG4107QZF nitrite reductase NADPH large subunit HRR29_RS21190 ENOG4105WZK nitrite reductase NADPH small subunit HRR29_RS21195 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HRR29_RS21200 ENOG4105VYH HRR29_RS21215 ENOG4105DJV ribulose-phosphate 3-epimerase HRR29_RS21220 ENOG4105DFE Dna adenine methylase HRR29_RS21225 ENOG4105EGB membrane protein DamX HRR29_RS21230 ENOG4105D49 3-dehydroquinate synthase HRR29_RS21235 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HRR29_RS21240 ENOG4105E4G Type IV pilus HRR29_RS21245 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HRR29_RS21260 ENOG4108U1Q Pilus assembly protein HRR29_RS21265 ENOG4108JQC penicillin-binding protein 1A HRR29_RS21270 ENOG4107RK2 ADP-ribose diphosphatase NudE HRR29_RS21275 ENOG4105DQY intracellular growth attenuator HRR29_RS21280 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HRR29_RS21285 ENOG4105VEJ Heat shock protein HRR29_RS21290 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HRR29_RS21295 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HRR29_RS21300 ENOG4105E0F Histidine kinase HRR29_RS21310 ENOG4108RRZ Transcription elongation factor GreB HRR29_RS21315 ENOG4105BZM domain protein HRR29_RS21320 ENOG4105XFK Ferrous iron transport protein A HRR29_RS21325 ENOG4105CE1 Ferrous iron transport protein b HRR29_RS21330 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HRR29_RS21340 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HRR29_RS21345 ENOG4105MJ2 Competence protein HRR29_RS21350 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HRR29_RS21355 ENOG4105C6Z Gluconate HRR29_RS21360 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HRR29_RS21365 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HRR29_RS21370 ENOG41061ZR Transcriptional regulator HRR29_RS21375 ENOG4105E98 transcriptional regulator DeoR family HRR29_RS21380 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HRR29_RS21385 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HRR29_RS21390 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HRR29_RS21395 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HRR29_RS21400 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HRR29_RS21405 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HRR29_RS21410 ENOG4108ESZ Glycogen debranching enzyme HRR29_RS21415 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HRR29_RS21420 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HRR29_RS21425 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HRR29_RS21430 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HRR29_RS21435 ENOG4105EX9 Membrane HRR29_RS21440 ENOG4108W1V Lipoprotein HRR29_RS21445 ENOG4105F9N Major Facilitator Superfamily HRR29_RS21450 ENOG4105DSF transport protein HRR29_RS21500 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HRR29_RS21525 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HRR29_RS21535 ENOG4105C2D reductase HRR29_RS21540 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HRR29_RS21545 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HRR29_RS21550 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HRR29_RS21560 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HRR29_RS21565 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HRR29_RS21570 ENOG4105C3I Nad-dependent epimerase dehydratase HRR29_RS21575 ENOG4105CKK Glycosyl transferase, family 2 HRR29_RS21585 ENOG4105PY6 Phenolic acid decarboxylase HRR29_RS21595 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HRR29_RS21600 ENOG4107TT5 NLP P60 protein HRR29_RS21625 ENOG4107258 Transcriptional regulator HRR29_RS21630 ENOG4105JSC dimethylmenaquinone methyltransferase HRR29_RS21635 ENOG4108JQ1 Dehydrogenase HRR29_RS21640 ENOG4105CBX hi0933 family HRR29_RS21645 ENOG4105CJ3 phosphate transporter HRR29_RS21655 ENOG4108V6B universal stress protein B HRR29_RS21665 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HRR29_RS21670 ENOG4105DGW oligopeptidase A HRR29_RS21675 ENOG4105D6S protein involved in catabolism of external DNA HRR29_RS21680 ENOG4105DC8 reductase HRR29_RS21700 ENOG4105CHR reductase HRR29_RS21705 ENOG4105CBN LysR family transcriptional regulator HRR29_RS21710 ENOG4107H3J ribonuclease HRR29_RS21715 ENOG4105CSH Transporter HRR29_RS21720 ENOG41066T0 asmA family HRR29_RS21725 ENOG4105CMB EAL domain-containing protein HRR29_RS21735 ENOG4105CS0 peptidase HRR29_RS21740 ENOG4105CK2 sodium dicarboxylate symporter HRR29_RS21745 ENOG4105BZU Histidine kinase HRR29_RS21750 ENOG4105EJG cellulose synthase HRR29_RS21755 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HRR29_RS21760 ENOG4107EEX Cellulose synthase regulator protein HRR29_RS21765 ENOG4107QZ7 Cellulose synthase catalytic subunit HRR29_RS21770 ENOG4105UTS cellulose synthase operon protein YhjQ HRR29_RS21775 ENOG410661M cytoplasmic protein HRR29_RS21780 ENOG4105U74 cellulose biosynthesis protein BcsE HRR29_RS21785 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT HRR29_RS21790 ENOG4105D1V cellulose synthase operon protein YhjU HRR29_RS21800 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HRR29_RS21805 ENOG4105D4A Cell wall formation (By similarity) HRR29_RS21835 ENOG4108RR8 protoporphyrinogen oxidase HRR29_RS21840 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HRR29_RS21845 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HRR29_RS21850 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HRR29_RS21855 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HRR29_RS21860 ENOG4105CHU acetyl-coa acetyltransferase HRR29_RS21865 ENOG4107QK7 reductase HRR29_RS21870 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HRR29_RS21875 ENOG4105MDZ Transcriptional activator rfaH HRR29_RS21880 ENOG4105F8V Hydrolase, tatD family HRR29_RS21885 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HRR29_RS21890 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HRR29_RS21895 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HRR29_RS21900 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HRR29_RS21905 ENOG4105JC1 sterol-binding domain protein HRR29_RS21910 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HRR29_RS21915 ENOG4105CGY Dna recombination protein HRR29_RS21920 ENOG4107SXA Phosphorylase HRR29_RS21925 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HRR29_RS21930 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HRR29_RS21935 ENOG4105DZ2 Transcriptional regulator HRR29_RS21940 ENOG4105EMK carboxylate amino acid amine transporter HRR29_RS21945 ENOG4105DQF Hydrolase HRR29_RS21950 ENOG4108EUD Lysophospholipase HRR29_RS21955 ENOG410829K Lysine exporter protein (Lyse ygga) HRR29_RS21960 ENOG4105CCF Lysine exporter protein (Lyse ygga) HRR29_RS21965 ENOG4105C9U ATP-dependent DNA helicase RecQ HRR29_RS21970 ENOG4105HDD phospholipase HRR29_RS21975 ENOG4108VUY thioesterase Superfamily protein HRR29_RS21980 ENOG4105FR1 rard protein HRR29_RS21985 ENOG4107QUT magnesium and cobalt transport protein CorA HRR29_RS21990 ENOG4105C4R Atp-dependent dna helicase HRR29_RS21995 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HRR29_RS22000 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HRR29_RS22005 ENOG4105CT0 Protein of unknown function, DUF484 HRR29_RS22015 ENOG4105S7Z (LipO)protein HRR29_RS22020 ENOG4105XQ6 frataxin-like protein HRR29_RS22025 ENOG4107T0K Adenylate cyclase HRR29_RS22030 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HRR29_RS22035 ENOG41076E6 Uroporphyrinogen-III Synthase HRR29_RS22040 ENOG4105ECF c-methyltransferase HRR29_RS22045 ENOG410601J HemY protein HRR29_RS22075 ENOG4105C85 amino acid HRR29_RS22080 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HRR29_RS22085 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HRR29_RS22090 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HRR29_RS22095 ENOG4105EGZ biosynthesis protein HRR29_RS22100 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HRR29_RS22105 ENOG4108WJ1 acetyltransferase HRR29_RS22110 ENOG4107QQG Dehydrogenase HRR29_RS22115 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HRR29_RS22120 ENOG4105SFE lipopolysaccharide biosynthesis protein HRR29_RS22125 ENOG4105ESV Glycosyl transferase, family 4 HRR29_RS22130 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HRR29_RS22145 ENOG4105C9X ppx gppa phosphatase HRR29_RS22150 ENOG4105C4R Atp-dependent dna helicase HRR29_RS22155 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HRR29_RS22160 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HRR29_RS22170 ENOG4105EMY transcriptional regulator HRR29_RS22175 ENOG4105C7B Threonine dehydratase HRR29_RS22185 ENOG4105CM2 brancheD-chain amino acid aminotransferase HRR29_RS22190 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HRR29_RS22205 ENOG4105C0P Mg chelatase subunit ChlI HRR29_RS22210 ENOG4108WFC UPF0438 protein yifE HRR29_RS22260 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HRR29_RS22265 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HRR29_RS22270 ENOG4108Y73 Membrane HRR29_RS22275 ENOG4105EJ2 Transcriptional regulator HRR29_RS22285 ENOG4105C5Q Transcriptional regulator HRR29_RS22290 ENOG4105CH7 arginosuccinase HRR29_RS22295 ENOG4105CAS nag kinase HRR29_RS22300 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HRR29_RS22305 ENOG4105CWC Acetylornithine deacetylase HRR29_RS22310 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HRR29_RS22315 ENOG4106R3P AraC family transcriptional regulator HRR29_RS22320 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HRR29_RS22325 ENOG4105DCT glycerol dehydrogenase HRR29_RS22330 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HRR29_RS22335 ENOG4105SYT Methylenetetrahydrofolate reductase HRR29_RS22340 ENOG4105CFH Aspartokinase HRR29_RS22345 ENOG4105C28 cystathionine HRR29_RS22350 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HRR29_RS22355 ENOG4105VFB Binds the 23S rRNA (By similarity) HRR29_RS22360 ENOG4105C25 Primosomal protein n' HRR29_RS22365 ENOG4105ETE Transcriptional regulator (LacI family HRR29_RS22370 ENOG41063M6 Cell Division Protein HRR29_RS22375 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HRR29_RS22380 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HRR29_RS22385 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HRR29_RS22390 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HRR29_RS22395 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HRR29_RS22400 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HRR29_RS22405 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HRR29_RS22410 ENOG4105CBT Fructose-1,6-bisphosphatase HRR29_RS22415 ENOG4105DP0 ferredoxin-NADP reductase HRR29_RS22425 ENOG41061MD high-affinity nickel-transporter HRR29_RS22475 ENOG4105W1Y Transcriptional regulator HRR29_RS22490 ENOG4108BUD transposase HRR29_RS22575 ENOG4108BUD transposase HRR29_RS22590 ENOG4108VTS Membrane HRR29_RS22595 ENOG4105EBK exported protein HRR29_RS22600 ENOG4105CP7 Triose-phosphate isomerase HRR29_RS22610 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) HRR29_RS22615 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HRR29_RS22620 ENOG4105CTQ phosphohexokinase HRR29_RS22625 ENOG41076HS cation diffusion facilitator family transporter HRR29_RS22630 ENOG4105FMW periplasmic HRR29_RS22635 ENOG4105E3W Two component transcriptional regulator (Winged helix family HRR29_RS22640 ENOG4105E0F Histidine kinase HRR29_RS22645 ENOG4108RPX mosc domain containing protein HRR29_RS22650 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HRR29_RS22655 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HRR29_RS22660 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HRR29_RS22665 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HRR29_RS22670 ENOG4105DET Rhamnulokinase HRR29_RS22675 ENOG4105DKG l-rhamnose isomerase HRR29_RS22680 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) HRR29_RS22685 ENOG4105C0A alcohol dehydrogenase HRR29_RS22690 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HRR29_RS22695 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HRR29_RS22715 ENOG4108UMN azlc family HRR29_RS22740 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HRR29_RS22745 ENOG4108MG3 formate dehydrogenase HRR29_RS22750 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HRR29_RS22760 ENOG41068KX affects formate dehydrogenase-N HRR29_RS22770 ENOG4105SUU thioesterase domain HRR29_RS22780 ENOG4107S2Z UPF0761 membrane protein HRR29_RS22785 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HRR29_RS22810 ENOG4105CI3 gtp-binding protein typa HRR29_RS22815 ENOG4105C5F glutamine synthetase HRR29_RS22820 ENOG4105CUX Signal transduction histidine kinase HRR29_RS22825 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HRR29_RS22830 ENOG4106FIY HRR29_RS22835 ENOG4105D4P Coproporphyrinogen iii oxidase HRR29_RS22840 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HRR29_RS22850 ENOG4105C2M dna polymerase I HRR29_RS22855 ENOG4106HNH Acyl-transferase HRR29_RS22860 ENOG4108Z33 Thiol disulfide Interchange Protein HRR29_RS22865 ENOG4105E27 serine threonine protein kinase HRR29_RS22870 ENOG4105PC1 Conserved Protein HRR29_RS22875 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HRR29_RS22880 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HRR29_RS22905 ENOG4107EJG GntR family transcriptional regulator HRR29_RS22910 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRR29_RS22915 ENOG4105ETE Transcriptional regulator (LacI family HRR29_RS22920 ENOG4108RVA ribokinase HRR29_RS22925 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HRR29_RS22930 ENOG4105CNN ABC, transporter HRR29_RS22935 ENOG4105C2J ABC transporter HRR29_RS22940 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HRR29_RS22945 ENOG4105DFH Transport of potassium into the cell (By similarity) HRR29_RS22955 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HRR29_RS22960 ENOG4105CU9 asparagine synthetase A HRR29_RS22965 ENOG4108VVK transcriptional Regulator, AsnC HRR29_RS22970 ENOG4105QTB Flavodoxin HRR29_RS22975 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HRR29_RS22980 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HRR29_RS22985 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HRR29_RS22990 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) HRR29_RS23000 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HRR29_RS23005 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HRR29_RS23010 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HRR29_RS23020 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HRR29_RS23025 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HRR29_RS23030 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HRR29_RS23035 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HRR29_RS23040 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HRR29_RS23045 ENOG4105C8U phosphate abc transporter HRR29_RS23050 ENOG4105E2Z phosphate ABC transporter (Permease HRR29_RS23055 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HRR29_RS23065 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HRR29_RS23070 ENOG4105C7N Xanthine uracil vitamin C permease HRR29_RS23075 ENOG4108YYH Nadph-dependent fmn reductase HRR29_RS23080 ENOG4105E8Q phosphopantetheinyl transferase HRR29_RS23085 ENOG4105G2Y Transcriptional regulator HRR29_RS23090 ENOG4105CNH Multidrug resistance protein MdtL HRR29_RS23095 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HRR29_RS23100 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HRR29_RS23115 ENOG4105VG0 50S ribosomal protein l34