locus-tag	class	description
A0R60_RS00010	COG2949	membrane
A0R60_RS00015	COG0295	cytidine deaminase activity
A0R60_RS00020	COG1346	cytolysis
A0R60_RS00035	COG3659	wide pore channel activity
A0R60_RS00050	COG2723	6-phospho-beta-galactosidase activity
A0R60_RS00065	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS00080	COG1686	Belongs to the peptidase S11 family
A0R60_RS00090	COG0277	FAD linked oxidase domain protein
A0R60_RS00095	COG1472	Belongs to the glycosyl hydrolase 3 family
A0R60_RS00100	COG1732	Glycine betaine
A0R60_RS00105	COG1174	glycine betaine transport
A0R60_RS00115	COG1174	glycine betaine transport
A0R60_RS00125	COG0789	Transcriptional regulator
A0R60_RS00130	COG3275	phosphorelay sensor kinase activity
A0R60_RS00140	COG4807	Protein conserved in bacteria
A0R60_RS00145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0R60_RS00145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0R60_RS00150	COG0489	protein tyrosine kinase activity
A0R60_RS00160	COG5455	response to cobalt ion
A0R60_RS00165	COG1596	polysaccharide export
A0R60_RS00170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A0R60_RS00175	COG0489	protein tyrosine kinase activity
A0R60_RS00175	COG3206	protein involved in exopolysaccharide biosynthesis
A0R60_RS00180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A0R60_RS00190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A0R60_RS00210	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A0R60_RS00215	COG0351	phosphomethylpyrimidine kinase
A0R60_RS00220	COG2188	Transcriptional regulator
A0R60_RS00225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A0R60_RS00235	COG2211	Major facilitator Superfamily
A0R60_RS00240	COG1830	Aldolase
A0R60_RS00245	COG1597	lipid kinase activity
A0R60_RS00250	COG1683	Conserved Protein
A0R60_RS00260	COG0826	peptidase U32
A0R60_RS00270	COG0745	RESPONSE REGULATOR receiver
A0R60_RS00275	COG2205	protein histidine kinase activity
A0R60_RS00285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A0R60_RS00290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A0R60_RS00295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0R60_RS00300	COG0443	Heat shock 70 kDa protein
A0R60_RS00305	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A0R60_RS00310	COG3447	MASE1 domain protein
A0R60_RS00310	COG5001	Diguanylate cyclase
A0R60_RS00310	COG5002	protein histidine kinase activity
A0R60_RS00320	COG0717	Belongs to the dCTP deaminase family
A0R60_RS00325	COG2982	Protein involved in outer membrane biogenesis
A0R60_RS00330	COG1253	flavin adenine dinucleotide binding
A0R60_RS00345	COG0489	protein tyrosine kinase activity
A0R60_RS00345	COG3206	protein involved in exopolysaccharide biosynthesis
A0R60_RS00350	COG0463	Glycosyl transferase, family 2
A0R60_RS00355	COG1045	serine acetyltransferase
A0R60_RS00360	COG0438	transferase activity, transferring glycosyl groups
A0R60_RS00370	COG1216	Glycosyl transferase, family 2
A0R60_RS00375	COG0110	maltose O-acetyltransferase activity
A0R60_RS00385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0R60_RS00390	COG1051	belongs to the nudix hydrolase family
A0R60_RS00405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A0R60_RS00410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A0R60_RS00415	COG2244	polysaccharide biosynthetic process
A0R60_RS00420	COG2327	Polysaccharide pyruvyl transferase
A0R60_RS00425	COG0438	transferase activity, transferring glycosyl groups
A0R60_RS00445	COG1091	dTDP-4-dehydrorhamnose reductase activity
A0R60_RS00470	COG2244	polysaccharide biosynthetic process
A0R60_RS00530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A0R60_RS00530	COG0140	phosphoribosyl-ATP diphosphatase activity
A0R60_RS00540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A0R60_RS00545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A0R60_RS00555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A0R60_RS00575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0R60_RS00580	COG0583	DNA-binding transcription factor activity
A0R60_RS00590	COG0531	amino acid
A0R60_RS00595	COG2925	Exonuclease
A0R60_RS00605	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A0R60_RS00610	COG1289	transmembrane transporter activity
A0R60_RS00640	COG0006	proline dipeptidase activity
A0R60_RS00645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A0R60_RS00650	COG0477	Major facilitator Superfamily
A0R60_RS00665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A0R60_RS00675	COG0589	response to stress
A0R60_RS00680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A0R60_RS00685	COG1376	ErfK ybiS ycfS ynhG family protein
A0R60_RS00730	COG0251	oxidation-reduction process
A0R60_RS00785	COG3046	protein related to deoxyribodipyrimidine photolyase
A0R60_RS00790	COG0583	DNA-binding transcription factor activity
A0R60_RS00825	COG4565	transcriptional regulatory protein
A0R60_RS00830	COG3290	protein histidine kinase activity
A0R60_RS00840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A0R60_RS00845	COG1418	mRNA catabolic process
A0R60_RS00850	COG0270	DNA (cytosine-5-)-methyltransferase activity
A0R60_RS00855	COG3727	T/G mismatch-specific endonuclease activity
A0R60_RS00860	COG0697	spore germination
A0R60_RS00865	COG2354	Protein conserved in bacteria
A0R60_RS00870	COG5475	Uncharacterized small protein (DUF2158)
A0R60_RS00905	COG1987	bacterial-type flagellum assembly
A0R60_RS00945	COG1157	protein secretion by the type III secretion system
A0R60_RS00965	COG1677	Flagellar hook-basal body complex protein FliE
A0R60_RS00970	COG0582	viral genome integration into host DNA
A0R60_RS01105	COG3756	Protein conserved in bacteria
A0R60_RS01335	COG0366	Alpha amylase catalytic
A0R60_RS01350	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A0R60_RS01375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0R60_RS01385	COG0765	amino acid transport
A0R60_RS01390	COG1126	abc transporter atp-binding protein
A0R60_RS01395	COG2197	response regulator
A0R60_RS01405	COG2197	response regulator
A0R60_RS01440	COG3416	Protein conserved in bacteria
A0R60_RS01450	COG0411	ABC transporter
A0R60_RS01470	COG3318	Belongs to the UPF0149 family
A0R60_RS01470	COG3012	SEC-C Motif Domain Protein
A0R60_RS01525	COG1528	Iron-storage protein
A0R60_RS01545	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A0R60_RS01550	COG1528	Iron-storage protein
A0R60_RS01555	COG1879	ABC-type sugar transport system periplasmic component
A0R60_RS01565	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0R60_RS01575	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A0R60_RS01615	COG1301	dicarboxylic acid transport
A0R60_RS01650	COG0840	transmembrane signaling receptor activity
A0R60_RS01665	COG0745	RESPONSE REGULATOR receiver
A0R60_RS01680	COG3188	usher protein
A0R60_RS01685	COG3121	Chaperone
A0R60_RS01715	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A0R60_RS01720	COG0018	arginyl-trna synthetase
A0R60_RS01725	COG3102	Protein conserved in bacteria
A0R60_RS01730	COG3142	Participates in the control of copper homeostasis
A0R60_RS01735	COG0500	methyltransferase
A0R60_RS01740	COG2226	methyltransferase
A0R60_RS01745	COG3788	relative of glutathione S-transferase, MAPEG superfamily
A0R60_RS01750	COG1801	Protein of unknown function DUF72
A0R60_RS01755	COG1335	isochorismatase
A0R60_RS01765	COG0494	nUDIX hydrolase
A0R60_RS01780	COG0632	four-way junction helicase activity
A0R60_RS01785	COG2255	four-way junction helicase activity
A0R60_RS01800	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A0R60_RS01805	COG0739	heme binding
A0R60_RS01820	COG1737	Transcriptional regulator
A0R60_RS01825	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A0R60_RS01830	COG0129	dihydroxy-acid dehydratase activity
A0R60_RS01835	COG0800	Aldolase
A0R60_RS01845	COG2979	Protein of unknown function (DUF533)
A0R60_RS01855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A0R60_RS01860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A0R60_RS01870	COG2372	response to copper ion
A0R60_RS01875	COG1276	copper resistance
A0R60_RS01900	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A0R60_RS01900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A0R60_RS01905	COG3008	intermembrane lipid transfer
A0R60_RS01910	COG2995	paraquat-inducible protein a
A0R60_RS01915	COG1956	GAF domain-containing protein
A0R60_RS01935	COG2814	Major facilitator Superfamily
A0R60_RS01940	COG1414	Transcriptional regulator
A0R60_RS01975	COG0768	penicillin binding
A0R60_RS01980	COG2226	methyltransferase
A0R60_RS01985	COG1971	Probably functions as a manganese efflux pump
A0R60_RS01990	COG4811	Protein of unknown function (DUF986)
A0R60_RS01995	COG3716	PTS system mannose fructose sorbose family IID component
A0R60_RS02000	COG3715	PTS system
A0R60_RS02005	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0R60_RS02005	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0R60_RS02010	COG1253	flavin adenine dinucleotide binding
A0R60_RS02035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A0R60_RS02045	COG0251	oxidation-reduction process
A0R60_RS02055	COG1214	PFAM Peptidase M22, glycoprotease
A0R60_RS02060	COG3065	identical protein binding
A0R60_RS02065	COG0318	PFAM AMP-dependent synthetase and ligase
A0R60_RS02070	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A0R60_RS02075	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A0R60_RS02080	COG2894	cell division
A0R60_RS02085	COG0850	regulation of cytokinetic process
A0R60_RS02090	COG3100	YcgL domain-containing protein
A0R60_RS02095	COG0179	Fumarylacetoacetate (FAA) hydrolase
A0R60_RS02100	COG2983	Belongs to the UPF0260 family
A0R60_RS02120	COG2719	SpoVR family
A0R60_RS02125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0R60_RS02130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A0R60_RS02135	COG3263	regulation of cellular component size
A0R60_RS02145	COG0741	lytic transglycosylase activity
A0R60_RS02160	COG4774	siderophore transport
A0R60_RS02175	COG2814	Major facilitator Superfamily
A0R60_RS02180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A0R60_RS02185	COG4977	sequence-specific DNA binding
A0R60_RS02200	COG0583	DNA-binding transcription factor activity
A0R60_RS02205	COG0243	molybdopterin cofactor binding
A0R60_RS02310	COG0515	serine threonine protein kinase
A0R60_RS02365	COG0012	GTP binding
A0R60_RS02370	COG0193	aminoacyl-tRNA hydrolase activity
A0R60_RS02395	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A0R60_RS02400	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A0R60_RS02405	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A0R60_RS02415	COG2890	protein-(glutamine-N5) methyltransferase activity
A0R60_RS02430	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A0R60_RS02435	COG0387	Pfam Sodium calcium exchanger
A0R60_RS02440	COG4572	Cation transport regulator
A0R60_RS02445	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A0R60_RS02455	COG0840	transmembrane signaling receptor activity
A0R60_RS02460	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A0R60_RS02465	COG3707	response regulator
A0R60_RS02490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A0R60_RS02490	COG2146	nitrite reductase [NAD(P)H] activity
A0R60_RS02500	COG4932	domain protein
A0R60_RS02505	COG2197	response regulator
A0R60_RS02510	COG3850	Histidine kinase
A0R60_RS02515	COG2223	nitrite transmembrane transporter activity
A0R60_RS02520	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A0R60_RS02525	COG1140	nitrate reductase beta subunit
A0R60_RS02530	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A0R60_RS02535	COG2181	nitrate reductase activity
A0R60_RS02540	COG0697	spore germination
A0R60_RS02545	COG1522	sequence-specific DNA binding
A0R60_RS02565	COG0788	formyltetrahydrofolate deformylase activity
A0R60_RS02570	COG3012	SEC-C Motif Domain Protein
A0R60_RS02575	COG1752	Esterase of the alpha-beta hydrolase superfamily
A0R60_RS02580	COG0745	RESPONSE REGULATOR receiver
A0R60_RS02585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A0R60_RS02595	COG1435	thymidine kinase activity
A0R60_RS02600	COG1012	belongs to the aldehyde dehydrogenase family
A0R60_RS02600	COG1454	alcohol dehydrogenase
A0R60_RS02605	COG2095	MarC family integral membrane protein
A0R60_RS02615	COG0601	transmembrane transport
A0R60_RS02625	COG0444	Belongs to the ABC transporter superfamily
A0R60_RS02635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A0R60_RS02640	COG3099	Belongs to the UPF0263 family
A0R60_RS02665	COG2350	Protein conserved in bacteria
A0R60_RS02690	COG0727	PFAM Uncharacterised protein family (UPF0153)
A0R60_RS02695	COG3047	cAMP biosynthetic process
A0R60_RS02705	COG0425	Belongs to the sulfur carrier protein TusA family
A0R60_RS02710	COG2391	methyltransferase activity
A0R60_RS02715	COG4566	intracellular signal transduction
A0R60_RS02725	COG0159	tryptophan synthase activity
A0R60_RS02730	COG0133	tryptophan synthase activity
A0R60_RS02740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A0R60_RS02740	COG0512	Glutamine amidotransferase of anthranilate synthase
A0R60_RS02755	COG0613	PHP domain protein
A0R60_RS02760	COG0009	L-threonylcarbamoyladenylate synthase
A0R60_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS02805	COG0616	signal peptide processing
A0R60_RS02830	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A0R60_RS02840	COG0671	phosphoesterase, PA-phosphatase related
A0R60_RS02845	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A0R60_RS02850	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A0R60_RS02855	COG0284	orotidine-5'-phosphate decarboxylase activity
A0R60_RS02860	COG0023	Translation Initiation Factor
A0R60_RS02880	COG1024	Enoyl-CoA hydratase
A0R60_RS02885	COG5001	Diguanylate cyclase
A0R60_RS02890	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A0R60_RS02900	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A0R60_RS02920	COG0745	RESPONSE REGULATOR receiver
A0R60_RS02925	COG5002	protein histidine kinase activity
A0R60_RS02945	COG4171	peptide transport system, permease
A0R60_RS02960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A0R60_RS02965	COG1842	Phage shock protein A
A0R60_RS02975	COG1983	PspC domain protein
A0R60_RS02985	COG0366	Alpha amylase catalytic
A0R60_RS02990	COG1653	transport
A0R60_RS02995	COG1175	transmembrane transport
A0R60_RS03000	COG0395	ABC-type sugar transport system, permease component
A0R60_RS03005	COG1063	alcohol dehydrogenase
A0R60_RS03010	COG1082	Xylose isomerase domain protein TIM barrel
A0R60_RS03015	COG0673	inositol 2-dehydrogenase activity
A0R60_RS03025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0R60_RS03040	COG1609	Transcriptional regulator
A0R60_RS03045	COG3106	COG3106 Predicted ATPase
A0R60_RS03050	COG3768	UPF0283 membrane protein
A0R60_RS03065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A0R60_RS03070	COG4948	Mandelate Racemase Muconate Lactonizing
A0R60_RS03075	COG2866	Carboxypeptidase
A0R60_RS03080	COG4166	transmembrane transport
A0R60_RS03085	COG0693	protein deglycase activity
A0R60_RS03095	COG3706	GGDEF domain
A0R60_RS03105	COG0840	transmembrane signaling receptor activity
A0R60_RS03120	COG0513	Belongs to the DEAD box helicase family
A0R60_RS03140	COG1917	Cupin 2, conserved barrel domain protein
A0R60_RS03150	COG1278	Cold shock
A0R60_RS03195	COG1013	pyruvate-flavodoxin oxidoreductase activity
A0R60_RS03195	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A0R60_RS03195	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0R60_RS03195	COG0674	pyruvate-flavodoxin oxidoreductase activity
A0R60_RS03200	COG3042	response to heat
A0R60_RS03205	COG3187	Heat shock protein
A0R60_RS03215	COG1294	oxidase, subunit
A0R60_RS03230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0R60_RS03245	COG1176	ABC-type spermidine putrescine transport system, permease component I
A0R60_RS03255	COG1012	belongs to the aldehyde dehydrogenase family
A0R60_RS03285	COG0747	negative chemotaxis
A0R60_RS03295	COG3238	Protein conserved in bacteria
A0R60_RS03300	COG1247	-acetyltransferase
A0R60_RS03310	COG2130	NADP-dependent
A0R60_RS03315	COG1802	Transcriptional regulator
A0R60_RS03320	COG4772	TonB-dependent receptor
A0R60_RS03350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A0R60_RS03350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A0R60_RS03360	COG1473	amidohydrolase
A0R60_RS03365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0R60_RS03370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0R60_RS03380	COG0765	amino acid transport
A0R60_RS03385	COG1126	abc transporter atp-binding protein
A0R60_RS03390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0R60_RS03395	COG0625	glutathione transferase activity
A0R60_RS03400	COG1942	4-Oxalocrotonate Tautomerase
A0R60_RS03405	COG1560	Kdo2-lipid A biosynthetic process
A0R60_RS03420	COG3493	citrate carrier protein
A0R60_RS03440	COG0640	Transcriptional regulator
A0R60_RS03445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A0R60_RS03450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A0R60_RS03455	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A0R60_RS03470	COG3158	transport of potassium into the cell
A0R60_RS03510	COG0583	DNA-binding transcription factor activity
A0R60_RS03530	COG0243	molybdopterin cofactor binding
A0R60_RS03530	COG3383	formate dehydrogenase (NAD+) activity
A0R60_RS03535	COG3383	formate dehydrogenase (NAD+) activity
A0R60_RS03535	COG0243	molybdopterin cofactor binding
A0R60_RS03540	COG0437	4 iron, 4 sulfur cluster binding
A0R60_RS03545	COG2864	formate dehydrogenase
A0R60_RS03570	COG2814	Major facilitator Superfamily
A0R60_RS03590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0R60_RS03605	COG1064	alcohol dehydrogenase
A0R60_RS03610	COG0488	(ABC) transporter
A0R60_RS03620	COG0281	malic enzyme
A0R60_RS03650	COG1764	response to oxidative stress
A0R60_RS03660	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS03665	COG4608	Belongs to the ABC transporter superfamily
A0R60_RS03670	COG0444	Belongs to the ABC transporter superfamily
A0R60_RS03675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0R60_RS03680	COG0601	transmembrane transport
A0R60_RS03685	COG0747	negative chemotaxis
A0R60_RS03690	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A0R60_RS03735	COG0840	transmembrane signaling receptor activity
A0R60_RS03740	COG0653	protein targeting
A0R60_RS03770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A0R60_RS03775	COG1649	PFAM Uncharacterised BCR, COG1649
A0R60_RS03780	COG4628	conserved protein (DUF2132)
A0R60_RS03785	COG3250	beta-galactosidase activity
A0R60_RS03835	COG1366	Belongs to the anti-sigma-factor antagonist family
A0R60_RS03845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A0R60_RS03850	COG0583	DNA-binding transcription factor activity
A0R60_RS03865	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A0R60_RS03935	COG0583	DNA-binding transcription factor activity
A0R60_RS03950	COG3188	usher protein
A0R60_RS03955	COG3121	Chaperone
A0R60_RS03995	COG0745	RESPONSE REGULATOR receiver
A0R60_RS04005	COG3039	Transposase
A0R60_RS04070	COG1349	DNA-binding transcription factor activity
A0R60_RS04080	COG2771	luxR family
A0R60_RS04090	COG4106	trans-aconitate 2-methyltransferase activity
A0R60_RS04110	COG0596	Alpha beta hydrolase
A0R60_RS04115	COG0456	acetyltransferase
A0R60_RS04130	COG3781	membrane
A0R60_RS04135	COG0246	Mannitol dehydrogenase
A0R60_RS04145	COG3706	GGDEF domain
A0R60_RS04150	COG2199	diguanylate cyclase activity
A0R60_RS04170	COG1012	belongs to the aldehyde dehydrogenase family
A0R60_RS04175	COG0583	DNA-binding transcription factor activity
A0R60_RS04185	COG1349	DNA-binding transcription factor activity
A0R60_RS04190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A0R60_RS04195	COG3395	kinase activity
A0R60_RS04200	COG1454	alcohol dehydrogenase
A0R60_RS04205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0R60_RS04240	COG2814	Major facilitator Superfamily
A0R60_RS04250	COG1846	Transcriptional regulator
A0R60_RS04270	COG2814	Major facilitator Superfamily
A0R60_RS04275	COG3443	Belongs to the bacterial solute-binding protein 9 family
A0R60_RS04285	COG1129	ABC transporter
A0R60_RS04305	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A0R60_RS04320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A0R60_RS04335	COG0826	peptidase U32
A0R60_RS04340	COG1396	sequence-specific DNA binding
A0R60_RS04345	COG3135	benzoate transporter
A0R60_RS04375	COG0747	negative chemotaxis
A0R60_RS04380	COG2195	Cleaves the N-terminal amino acid of tripeptides
A0R60_RS04385	COG0500	methyltransferase
A0R60_RS04390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A0R60_RS04395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A0R60_RS04400	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A0R60_RS04410	COG0436	Aminotransferase
A0R60_RS04425	COG5383	Protein conserved in bacteria
A0R60_RS04430	COG3729	General stress protein
A0R60_RS04435	COG3685	Protein conserved in bacteria
A0R60_RS04445	COG3685	Protein conserved in bacteria
A0R60_RS04450	COG3546	catalase activity
A0R60_RS04460	COG1294	oxidase, subunit
A0R60_RS04475	COG1546	Belongs to the CinA family
A0R60_RS04490	COG3111	PFAM Bacterial OB fold (BOF) protein
A0R60_RS04495	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS04500	COG0583	DNA-binding transcription factor activity
A0R60_RS04510	COG0840	transmembrane signaling receptor activity
A0R60_RS04530	COG2814	Major facilitator Superfamily
A0R60_RS04535	COG0402	S-adenosylhomocysteine deaminase activity
A0R60_RS04550	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A0R60_RS04570	COG0583	DNA-binding transcription factor activity
A0R60_RS04575	COG0456	acetyltransferase
A0R60_RS04580	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A0R60_RS04620	COG1349	DNA-binding transcription factor activity
A0R60_RS04625	COG0673	inositol 2-dehydrogenase activity
A0R60_RS04630	COG3038	cytochrome b561
A0R60_RS04635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A0R60_RS04640	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A0R60_RS04665	COG4122	O-methyltransferase activity
A0R60_RS04715	COG0583	DNA-binding transcription factor activity
A0R60_RS04745	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A0R60_RS04795	COG0300	oxidoreductase activity
A0R60_RS04820	COG1902	pentaerythritol trinitrate reductase activity
A0R60_RS04825	COG0583	DNA-binding transcription factor activity
A0R60_RS04865	COG2249	NAD(P)H dehydrogenase (quinone) activity
A0R60_RS04870	COG2826	transposase and inactivated derivatives, IS30 family
A0R60_RS04900	COG1846	Transcriptional regulator
A0R60_RS04925	COG0386	Belongs to the glutathione peroxidase family
A0R60_RS04930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A0R60_RS04935	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS04940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A0R60_RS04960	COG2050	protein possibly involved in aromatic compounds catabolism
A0R60_RS04965	COG1250	3-hydroxyacyl-CoA dehydrogenase
A0R60_RS04970	COG1024	Enoyl-CoA hydratase
A0R60_RS04980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A0R60_RS04985	COG2151	metal-sulfur cluster biosynthetic enzyme
A0R60_RS04990	COG3396	Phenylacetate-CoA oxygenase
A0R60_RS04995	COG3460	Phenylacetate-CoA oxygenase
A0R60_RS05000	COG3396	Phenylacetate-CoA oxygenase
A0R60_RS05005	COG2030	dehydratase
A0R60_RS05005	COG1012	belongs to the aldehyde dehydrogenase family
A0R60_RS05030	COG3706	GGDEF domain
A0R60_RS05035	COG1012	belongs to the aldehyde dehydrogenase family
A0R60_RS05045	COG3784	Protein of unknown function (DUF1318)
A0R60_RS05055	COG2911	Protein conserved in bacteria
A0R60_RS05065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A0R60_RS05095	COG4221	oxidoreductase activity
A0R60_RS05100	COG1802	Transcriptional regulator
A0R60_RS05105	COG0589	response to stress
A0R60_RS05115	COG0246	Mannitol dehydrogenase
A0R60_RS05120	COG0477	Major facilitator Superfamily
A0R60_RS05125	COG1063	alcohol dehydrogenase
A0R60_RS05130	COG4948	Mandelate Racemase Muconate Lactonizing
A0R60_RS05135	COG1742	UPF0060 membrane protein
A0R60_RS05145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A0R60_RS05165	COG3381	protein complex oligomerization
A0R60_RS05190	COG0745	RESPONSE REGULATOR receiver
A0R60_RS05210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0R60_RS05215	COG3708	Transcriptional regulator
A0R60_RS05215	COG2207	Transcriptional regulator
A0R60_RS05220	COG3141	response to X-ray
A0R60_RS05240	COG4319	ketosteroid isomerase
A0R60_RS05315	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A0R60_RS05320	COG1940	carbohydrate kinase activity
A0R60_RS05325	COG0583	DNA-binding transcription factor activity
A0R60_RS05335	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A0R60_RS05355	COG2076	Multidrug Resistance protein
A0R60_RS05360	COG0628	permease
A0R60_RS05375	COG1403	HNH endonuclease
A0R60_RS05390	COG5002	protein histidine kinase activity
A0R60_RS05390	COG3850	Histidine kinase
A0R60_RS05410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0R60_RS05440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A0R60_RS05450	COG0667	Aldo Keto reductase
A0R60_RS05460	COG2840	Smr protein MutS2
A0R60_RS05465	COG0583	DNA-binding transcription factor activity
A0R60_RS05480	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A0R60_RS05485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A0R60_RS05510	COG3539	Fimbrial protein
A0R60_RS05525	COG3121	Chaperone
A0R60_RS05545	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A0R60_RS05550	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A0R60_RS05560	COG0531	amino acid
A0R60_RS05565	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS05570	COG3136	membrane protein required for alginate biosynthesis
A0R60_RS05575	COG0745	RESPONSE REGULATOR receiver
A0R60_RS05585	COG2205	protein histidine kinase activity
A0R60_RS05595	COG0114	fumarate hydratase activity
A0R60_RS05600	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A0R60_RS05600	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A0R60_RS05610	COG5339	Protein conserved in bacteria
A0R60_RS05620	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A0R60_RS05630	COG1609	Transcriptional regulator
A0R60_RS05635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0R60_RS05635	COG1263	PTS System
A0R60_RS05645	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A0R60_RS05650	COG0673	inositol 2-dehydrogenase activity
A0R60_RS05690	COG4659	FMN binding
A0R60_RS05700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A0R60_RS05705	COG3104	oligopeptide transport
A0R60_RS05710	COG0625	glutathione transferase activity
A0R60_RS05715	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A0R60_RS05720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A0R60_RS05725	COG0259	pyridoxamine-phosphate oxidase activity
A0R60_RS05730	COG3895	Periplasmic Protein
A0R60_RS05735	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A0R60_RS05745	COG3706	GGDEF domain
A0R60_RS05760	COG1566	PFAM secretion protein HlyD family protein
A0R60_RS05765	COG1289	transmembrane transporter activity
A0R60_RS05770	COG2032	superoxide dismutase activity
A0R60_RS05775	COG4989	oxidoreductase activity
A0R60_RS05780	COG3313	Fe-S protein
A0R60_RS05785	COG2194	sulfuric ester hydrolase activity
A0R60_RS05790	COG1309	transcriptional regulator
A0R60_RS05795	COG1902	pentaerythritol trinitrate reductase activity
A0R60_RS05800	COG0346	lactoylglutathione lyase activity
A0R60_RS05805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A0R60_RS05810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A0R60_RS05815	COG0791	NLP P60 protein
A0R60_RS05825	COG2814	Major facilitator Superfamily
A0R60_RS05840	COG0583	DNA-binding transcription factor activity
A0R60_RS05845	COG2814	Major facilitator Superfamily
A0R60_RS05850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A0R60_RS05855	COG0307	riboflavin synthase, alpha
A0R60_RS05860	COG0534	Mate efflux family protein
A0R60_RS05875	COG4529	Protein conserved in bacteria
A0R60_RS05895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0R60_RS05905	COG0765	amino acid transport
A0R60_RS05910	COG0765	amino acid transport
A0R60_RS05920	COG1464	Belongs to the NlpA lipoprotein family
A0R60_RS05925	COG2011	ABC-type metal ion transport system permease component
A0R60_RS05940	COG0626	cystathionine gamma-synthase activity
A0R60_RS05955	COG1376	ErfK ybiS ycfS ynhG family protein
A0R60_RS05960	COG2166	iron-sulfur cluster assembly
A0R60_RS05965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A0R60_RS05970	COG0719	Fe-S assembly protein
A0R60_RS05975	COG0396	ATPase activity
A0R60_RS05980	COG0719	Fe-S assembly protein
A0R60_RS05985	COG0316	Belongs to the HesB IscA family
A0R60_RS05995	COG0789	Transcriptional regulator
A0R60_RS06000	COG2200	EAL domain
A0R60_RS06030	COG2050	protein possibly involved in aromatic compounds catabolism
A0R60_RS06045	COG0628	permease
A0R60_RS06055	COG1472	Belongs to the glycosyl hydrolase 3 family
A0R60_RS06060	COG2211	Major facilitator Superfamily
A0R60_RS06065	COG0574	Belongs to the PEP-utilizing enzyme family
A0R60_RS06065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A0R60_RS06070	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A0R60_RS06075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A0R60_RS06080	COG4256	Hemin uptake protein
A0R60_RS06090	COG3720	iron ion transport
A0R60_RS06095	COG4558	Periplasmic binding protein
A0R60_RS06110	COG0583	DNA-binding transcription factor activity
A0R60_RS06115	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A0R60_RS06120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A0R60_RS06130	COG2610	gluconate transmembrane transporter activity
A0R60_RS06135	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS06140	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A0R60_RS06150	COG0791	NLP P60 protein
A0R60_RS06160	COG0386	Belongs to the glutathione peroxidase family
A0R60_RS06165	COG4139	cobalamin transport
A0R60_RS06170	COG0776	regulation of translation
A0R60_RS06175	COG0072	phenylalanine-tRNA ligase activity
A0R60_RS06175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0R60_RS06180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A0R60_RS06205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A0R60_RS06220	COG3137	Salt-induced outer membrane protein
A0R60_RS06225	COG1105	Belongs to the carbohydrate kinase PfkB family
A0R60_RS06250	COG1988	membrane-bound metal-dependent
A0R60_RS06255	COG1823	symporter activity
A0R60_RS06265	COG0753	catalase activity
A0R60_RS06275	COG1486	melibiose metabolic process
A0R60_RS06280	COG2169	Transcriptional regulator
A0R60_RS06280	COG1917	Cupin 2, conserved barrel domain protein
A0R60_RS06285	COG1447	Phosphotransferase system cellobiose-specific component IIA
A0R60_RS06290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A0R60_RS06295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A0R60_RS06300	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A0R60_RS06305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A0R60_RS06310	COG0322	excinuclease ABC activity
A0R60_RS06320	COG3678	ATP-independent chaperone mediated protein folding
A0R60_RS06330	COG3724	N-succinylarginine dihydrolase activity
A0R60_RS06335	COG1012	belongs to the aldehyde dehydrogenase family
A0R60_RS06340	COG3138	arginine N-succinyltransferase
A0R60_RS06350	COG0708	Exodeoxyribonuclease III
A0R60_RS06360	COG4134	Bacterial extracellular solute-binding protein
A0R60_RS06370	COG4136	ATPase activity
A0R60_RS06375	COG2897	thiosulfate sulfurtransferase activity
A0R60_RS06380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A0R60_RS06385	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A0R60_RS06390	COG0494	nUDIX hydrolase
A0R60_RS06410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A0R60_RS06415	COG0709	Synthesizes selenophosphate from selenide and ATP
A0R60_RS06420	COG0778	Nitroreductase
A0R60_RS06425	COG0616	signal peptide processing
A0R60_RS06430	COG0252	asparaginase activity
A0R60_RS06435	COG1335	isochorismatase
A0R60_RS06440	COG3139	Protein of unknown function (DUF1315)
A0R60_RS06460	COG3713	MltA-interacting MipA family protein
A0R60_RS06465	COG2766	serine protein kinase
A0R60_RS06470	COG2718	Belongs to the UPF0229 family
A0R60_RS06475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A0R60_RS06490	COG2207	Transcriptional regulator
A0R60_RS06495	COG2807	transmembrane transport
A0R60_RS06500	COG0504	CTP synthase activity
A0R60_RS06505	COG3189	MarR family transcriptional regulator
A0R60_RS06515	COG3042	response to heat
A0R60_RS06520	COG2199	diguanylate cyclase activity
A0R60_RS06520	COG2203	Gaf domain
A0R60_RS06540	COG3706	GGDEF domain
A0R60_RS06540	COG4251	negative regulation of phosphorylation
A0R60_RS06540	COG5001	Diguanylate cyclase
A0R60_RS06540	COG2203	Gaf domain
A0R60_RS06545	COG2200	EAL domain
A0R60_RS06565	COG0538	isocitrate dehydrogenase activity
A0R60_RS06585	COG2915	High frequency lysogenization protein hflD homolog
A0R60_RS06590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A0R60_RS06635	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A0R60_RS06640	COG0840	transmembrane signaling receptor activity
A0R60_RS06645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A0R60_RS06655	COG4591	ABC-type transport system involved in lipoprotein release permease component
A0R60_RS06660	COG1136	(ABC) transporter
A0R60_RS06670	COG4763	Acyl-transferase
A0R60_RS06675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A0R60_RS06680	COG1388	LysM domain
A0R60_RS06680	COG1376	ErfK ybiS ycfS ynhG family protein
A0R60_RS06690	COG1309	transcriptional regulator
A0R60_RS06700	COG1252	NADH dehydrogenase
A0R60_RS06705	COG3150	esterase
A0R60_RS06720	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
A0R60_RS06725	COG5633	Lipoprotein
A0R60_RS06730	COG0537	adenosine 5'-monophosphoramidase activity
A0R60_RS06745	COG0470	DNA polymerase III
A0R60_RS06755	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A0R60_RS06760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A0R60_RS06765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0R60_RS06770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A0R60_RS06785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A0R60_RS06790	COG0416	fatty acid biosynthetic process
A0R60_RS06795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A0R60_RS06805	COG0424	maF-like protein
A0R60_RS06810	COG0564	pseudouridine synthase activity
A0R60_RS06820	COG1530	ribonuclease E activity
A0R60_RS06825	COG0583	DNA-binding transcription factor activity
A0R60_RS06830	COG2814	Major facilitator Superfamily
A0R60_RS06835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A0R60_RS06840	COG1256	bacterial-type flagellum assembly
A0R60_RS06865	COG4787	bacterial-type flagellum-dependent cell motility
A0R60_RS06870	COG1749	Flagellar hook protein flgE
A0R60_RS06875	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A0R60_RS06880	COG1558	bacterial-type flagellum-dependent cell motility
A0R60_RS06910	COG0673	inositol 2-dehydrogenase activity
A0R60_RS06915	COG3132	Protein of unknown function, DUF480
A0R60_RS06920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A0R60_RS06925	COG0477	Major facilitator Superfamily
A0R60_RS06940	COG0418	dihydroorotase activity
A0R60_RS06965	COG3038	cytochrome b561
A0R60_RS06970	COG2353	YceI-like domain
A0R60_RS06975	COG1054	Belongs to the UPF0176 family
A0R60_RS06980	COG1560	Kdo2-lipid A biosynthetic process
A0R60_RS06995	COG5645	(Lipo)protein
A0R60_RS07020	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A0R60_RS07045	COG2197	response regulator
A0R60_RS07070	COG3381	protein complex oligomerization
A0R60_RS07075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A0R60_RS07080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A0R60_RS07095	COG0583	DNA-binding transcription factor activity
A0R60_RS07105	COG1335	isochorismatase
A0R60_RS07115	COG1115	amino acid carrier protein
A0R60_RS07130	COG2822	iron ion transport
A0R60_RS07145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A0R60_RS07155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A0R60_RS07160	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A0R60_RS07160	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A0R60_RS07160	COG0506	proline dehydrogenase activity
A0R60_RS07170	COG1309	transcriptional regulator
A0R60_RS07175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0R60_RS07180	COG1335	isochorismatase
A0R60_RS07185	COG0251	oxidation-reduction process
A0R60_RS07190	COG2267	carboxylic ester hydrolase activity
A0R60_RS07195	COG0778	Nitroreductase
A0R60_RS07205	COG2233	PERMEase
A0R60_RS07225	COG3729	General stress protein
A0R60_RS07230	COG0655	NAD(P)H dehydrogenase (quinone) activity
A0R60_RS07255	COG1733	regulation of RNA biosynthetic process
A0R60_RS07260	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS07265	COG0586	Pfam SNARE associated Golgi protein
A0R60_RS07270	COG2239	Acts as a magnesium transporter
A0R60_RS07280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A0R60_RS07285	COG1126	abc transporter atp-binding protein
A0R60_RS07290	COG0765	amino acid transport
A0R60_RS07345	COG1953	Uracil, thiamine, allantoin
A0R60_RS07350	COG0402	S-adenosylhomocysteine deaminase activity
A0R60_RS07355	COG2351	hydroxyisourate hydrolase activity
A0R60_RS07360	COG3195	allantoin biosynthetic process
A0R60_RS07360	COG3648	Uricase
A0R60_RS07365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0R60_RS07390	COG1696	Membrane protein involved in D-alanine export
A0R60_RS07395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A0R60_RS07410	COG4106	trans-aconitate 2-methyltransferase activity
A0R60_RS07420	COG0582	viral genome integration into host DNA
A0R60_RS07465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A0R60_RS07480	COG1204	response to ionizing radiation
A0R60_RS07610	COG0670	Belongs to the BI1 family
A0R60_RS07620	COG1254	Belongs to the acylphosphatase family
A0R60_RS07630	COG1881	PFAM PEBP family protein
A0R60_RS07635	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A0R60_RS07645	COG1832	CoA-binding protein
A0R60_RS07650	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A0R60_RS07655	COG1803	Methylglyoxal synthase
A0R60_RS07665	COG3304	Inner membrane component domain
A0R60_RS07680	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
A0R60_RS07690	COG3120	sequence-specific DNA binding
A0R60_RS07695	COG1067	ATP-dependent peptidase activity
A0R60_RS07705	COG3130	regulation of translation
A0R60_RS07710	COG3009	Protein conserved in bacteria
A0R60_RS07715	COG3008	intermembrane lipid transfer
A0R60_RS07715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A0R60_RS07720	COG2995	paraquat-inducible protein a
A0R60_RS07725	COG0488	(ABC) transporter
A0R60_RS07730	COG0116	Belongs to the methyltransferase superfamily
A0R60_RS07730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A0R60_RS07735	COG0633	Ferredoxin
A0R60_RS07735	COG3217	Mosc domain protein beta barrel domain protein
A0R60_RS07755	COG0431	NADPH-dependent FMN reductase
A0R60_RS07760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A0R60_RS07765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0R60_RS07770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A0R60_RS07780	COG0308	aminopeptidase N
A0R60_RS07785	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A0R60_RS07790	COG0017	Asparaginyl-tRNA synthetase
A0R60_RS07800	COG1448	Aminotransferase
A0R60_RS07805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0R60_RS07810	COG3108	Peptidase M15
A0R60_RS07820	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A0R60_RS07825	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A0R60_RS07835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A0R60_RS07840	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A0R60_RS07845	COG3173	Aminoglycoside phosphotransferase
A0R60_RS07855	COG2835	tetraacyldisaccharide 4'-kinase activity
A0R60_RS07880	COG0776	regulation of translation
A0R60_RS07890	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A0R60_RS07895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A0R60_RS07905	COG2323	membrane
A0R60_RS07910	COG1944	ATP diphosphatase activity
A0R60_RS07915	COG2116	formate transmembrane transporter activity
A0R60_RS07920	COG1882	Formate acetyltransferase
A0R60_RS07925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A0R60_RS07935	COG0477	Major facilitator Superfamily
A0R60_RS07940	COG3302	dmso reductase anchor subunit
A0R60_RS07950	COG0243	molybdopterin cofactor binding
A0R60_RS07955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A0R60_RS07960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A0R60_RS07965	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A0R60_RS07970	COG1674	ftsk spoiiie
A0R60_RS07970	COG1178	ABC-type Fe3 transport system permease component
A0R60_RS07985	COG0492	ferredoxin-NADP+ reductase activity
A0R60_RS07990	COG4988	ABC transporter
A0R60_RS08000	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A0R60_RS08005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A0R60_RS08020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A0R60_RS08025	COG1278	Cold shock
A0R60_RS08035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0R60_RS08045	COG3593	DNA synthesis involved in DNA repair
A0R60_RS08055	COG2431	L-lysine efflux transmembrane transporter activity
A0R60_RS08060	COG1151	hydroxylamine reductase activity
A0R60_RS08065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A0R60_RS08075	COG0028	Belongs to the TPP enzyme family
A0R60_RS08080	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A0R60_RS08090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0R60_RS08115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A0R60_RS08120	COG3023	N-Acetylmuramoyl-L-alanine amidase
A0R60_RS08125	COG0393	Putative heavy-metal-binding
A0R60_RS08135	COG1126	abc transporter atp-binding protein
A0R60_RS08140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0R60_RS08145	COG4215	(ABC) transporter
A0R60_RS08150	COG4160	amino acid transport
A0R60_RS08155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0R60_RS08160	COG5002	protein histidine kinase activity
A0R60_RS08170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A0R60_RS08180	COG1177	transmembrane transport
A0R60_RS08185	COG1176	ABC-type spermidine putrescine transport system, permease component I
A0R60_RS08190	COG3842	ATPase activity
A0R60_RS08195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A0R60_RS08210	COG0189	ligase activity
A0R60_RS08215	COG0778	Nitroreductase
A0R60_RS08230	COG0569	domain protein
A0R60_RS08230	COG2985	domain, Protein
A0R60_RS08235	COG0640	Transcriptional regulator
A0R60_RS08240	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A0R60_RS08245	COG1393	Belongs to the ArsC family
A0R60_RS08250	COG3226	Transcriptional regulator
A0R60_RS08255	COG0738	Major facilitator superfamily
A0R60_RS08260	COG0561	phosphatase activity
A0R60_RS08265	COG2814	Major facilitator Superfamily
A0R60_RS08285	COG1686	Belongs to the peptidase S11 family
A0R60_RS08290	COG0625	glutathione transferase activity
A0R60_RS08295	COG2133	pyrroloquinoline quinone binding
A0R60_RS08340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A0R60_RS08345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A0R60_RS08355	COG1882	Formate acetyltransferase
A0R60_RS08360	COG0561	phosphatase activity
A0R60_RS08370	COG1609	Transcriptional regulator
A0R60_RS08375	COG2271	Major facilitator Superfamily
A0R60_RS08390	COG0488	(ABC) transporter
A0R60_RS08395	COG1376	ErfK ybiS ycfS ynhG family protein
A0R60_RS08405	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A0R60_RS08410	COG2723	6-phospho-beta-galactosidase activity
A0R60_RS08415	COG0667	Aldo Keto reductase
A0R60_RS08425	COG2814	Major facilitator Superfamily
A0R60_RS08430	COG1566	PFAM secretion protein HlyD family protein
A0R60_RS08440	COG1321	iron dependent repressor
A0R60_RS08450	COG2194	sulfuric ester hydrolase activity
A0R60_RS08455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A0R60_RS08465	COG0783	Belongs to the Dps family
A0R60_RS08470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0R60_RS08475	COG0765	amino acid transport
A0R60_RS08480	COG1126	abc transporter atp-binding protein
A0R60_RS08485	COG0668	transmembrane transport
A0R60_RS08490	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A0R60_RS08505	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A0R60_RS08515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A0R60_RS08550	COG0513	Belongs to the DEAD box helicase family
A0R60_RS08555	COG1309	transcriptional regulator
A0R60_RS08565	COG1131	(ABC) transporter
A0R60_RS08570	COG0842	Transport permease protein
A0R60_RS08575	COG0842	Transport permease protein
A0R60_RS08585	COG3568	Endonuclease Exonuclease Phosphatase
A0R60_RS08590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A0R60_RS08595	COG0392	lysyltransferase activity
A0R60_RS08600	COG0670	Belongs to the BI1 family
A0R60_RS08605	COG0314	molybdopterin synthase activity
A0R60_RS08615	COG0315	cyclic pyranopterin monophosphate synthase activity
A0R60_RS08620	COG0521	Mo-molybdopterin cofactor biosynthetic process
A0R60_RS08645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A0R60_RS08650	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A0R60_RS08655	COG2226	methyltransferase
A0R60_RS08660	COG0156	8-amino-7-oxononanoate synthase activity
A0R60_RS08665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A0R60_RS08670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A0R60_RS08675	COG1881	PFAM PEBP family protein
A0R60_RS08680	COG2986	histidine ammonia-lyase
A0R60_RS08685	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A0R60_RS08695	COG0010	Belongs to the arginase family
A0R60_RS08705	COG4677	pectinesterase activity
A0R60_RS08720	COG0561	phosphatase activity
A0R60_RS08730	COG2200	EAL domain
A0R60_RS08730	COG2199	diguanylate cyclase activity
A0R60_RS08780	COG0561	phosphatase activity
A0R60_RS08790	COG4149	molybdate abc transporter
A0R60_RS08795	COG0725	ABC transporter, periplasmic molybdate-binding protein
A0R60_RS08810	COG1119	ATPase activity
A0R60_RS08815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A0R60_RS08825	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A0R60_RS08830	COG2017	converts alpha-aldose to the beta-anomer
A0R60_RS08840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A0R60_RS08850	COG1230	cation diffusion facilitator family transporter
A0R60_RS08855	COG3201	nicotinamide mononucleotide transporter
A0R60_RS08860	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A0R60_RS08890	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A0R60_RS08895	COG2885	chlorophyll binding
A0R60_RS08905	COG3064	Membrane
A0R60_RS08910	COG0848	biopolymer transport protein
A0R60_RS08915	COG0811	peptide transport
A0R60_RS08920	COG0824	Thioesterase
A0R60_RS08925	COG3790	cyd operon protein YbgE
A0R60_RS08930	COG4890	Cyd operon protein YbgT
A0R60_RS08935	COG1294	oxidase, subunit
A0R60_RS08940	COG1271	oxidase subunit
A0R60_RS08945	COG0383	alpha-mannosidase activity
A0R60_RS08955	COG2188	Transcriptional regulator
A0R60_RS08960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A0R60_RS08965	COG0045	succinate-CoA ligase (ADP-forming) activity
A0R60_RS08970	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0R60_RS08980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A0R60_RS08990	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A0R60_RS08995	COG2009	succinate dehydrogenase
A0R60_RS09000	COG0372	Belongs to the citrate synthase family
A0R60_RS09005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A0R60_RS09020	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A0R60_RS09025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A0R60_RS09030	COG0415	Belongs to the DNA photolyase family
A0R60_RS09045	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A0R60_RS09050	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A0R60_RS09055	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A0R60_RS09060	COG2205	protein histidine kinase activity
A0R60_RS09065	COG0745	RESPONSE REGULATOR receiver
A0R60_RS09090	COG0531	amino acid
A0R60_RS09095	COG0033	Phosphoglucomutase
A0R60_RS09100	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A0R60_RS09105	COG0596	Alpha beta hydrolase
A0R60_RS09125	COG0735	belongs to the Fur family
A0R60_RS09140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0R60_RS09145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0R60_RS09145	COG2190	(PTS) system
A0R60_RS09145	COG1263	PTS System
A0R60_RS09155	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A0R60_RS09160	COG1940	carbohydrate kinase activity
A0R60_RS09160	COG1846	Transcriptional regulator
A0R60_RS09165	COG0647	UMP catabolic process
A0R60_RS09170	COG0367	asparagine synthase
A0R60_RS09210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0R60_RS09215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A0R60_RS09220	COG1702	phosphate starvation-inducible protein PhoH
A0R60_RS09225	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A0R60_RS09245	COG0765	amino acid transport
A0R60_RS09250	COG0765	amino acid transport
A0R60_RS09255	COG1126	abc transporter atp-binding protein
A0R60_RS09260	COG1957	nucleoside hydrolase
A0R60_RS09265	COG2888	peptidyl-tyrosine sulfation
A0R60_RS09280	COG1466	dna polymerase III delta subunit
A0R60_RS09290	COG0799	negative regulation of ribosome biogenesis
A0R60_RS09300	COG0768	penicillin binding
A0R60_RS09310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A0R60_RS09315	COG1686	Belongs to the peptidase S11 family
A0R60_RS09320	COG2921	Belongs to the UPF0250 family
A0R60_RS09325	COG0321	lipoyl(octanoyl) transferase activity
A0R60_RS09330	COG0583	DNA-binding transcription factor activity
A0R60_RS09335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A0R60_RS09340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A0R60_RS09345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A0R60_RS09350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A0R60_RS09365	COG3069	C4-dicarboxylate transmembrane transporter activity
A0R60_RS09370	COG3719	Belongs to the RNase T2 family
A0R60_RS09380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A0R60_RS09405	COG0583	DNA-binding transcription factor activity
A0R60_RS09410	COG3969	phosphoadenosine phosphosulfate
A0R60_RS09415	COG1475	DNA binding
A0R60_RS09420	COG0436	Aminotransferase
A0R60_RS09425	COG0235	Class ii aldolase
A0R60_RS09430	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
A0R60_RS09445	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A0R60_RS09450	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
A0R60_RS09465	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0R60_RS09470	COG1129	ABC transporter
A0R60_RS09475	COG0371	Dehydrogenase
A0R60_RS09495	COG2879	small protein
A0R60_RS09505	COG2050	protein possibly involved in aromatic compounds catabolism
A0R60_RS09510	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS09520	COG1021	2,3-dihydroxybenzoate-AMP ligase
A0R60_RS09525	COG1169	isochorismate synthase
A0R60_RS09530	COG4592	Periplasmic binding protein
A0R60_RS09540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0R60_RS09545	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0R60_RS09550	COG1120	ATPase activity
A0R60_RS09555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A0R60_RS09555	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A0R60_RS09560	COG3251	PFAM MbtH domain protein
A0R60_RS09565	COG2382	esterase
A0R60_RS09570	COG4771	TonB-dependent receptor
A0R60_RS09580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A0R60_RS09600	COG4221	oxidoreductase activity
A0R60_RS09620	COG0601	transmembrane transport
A0R60_RS09625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0R60_RS09635	COG4608	Belongs to the ABC transporter superfamily
A0R60_RS09700	COG1566	PFAM secretion protein HlyD family protein
A0R60_RS09710	COG1289	transmembrane transporter activity
A0R60_RS09715	COG2207	Transcriptional regulator
A0R60_RS09725	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A0R60_RS09750	COG2207	Transcriptional regulator
A0R60_RS09765	COG2315	Protein conserved in bacteria
A0R60_RS09770	COG0778	Nitroreductase
A0R60_RS09785	COG0477	Major facilitator Superfamily
A0R60_RS09790	COG0668	transmembrane transport
A0R60_RS09795	COG1113	amino acid transport
A0R60_RS09890	COG2501	S4 domain
A0R60_RS09895	COG2190	(PTS) system
A0R60_RS09895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0R60_RS09895	COG1263	PTS System
A0R60_RS09905	COG1988	membrane-bound metal-dependent
A0R60_RS09915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A0R60_RS09920	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0R60_RS09935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A0R60_RS09940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A0R60_RS09960	COG4181	ATPase activity
A0R60_RS09965	COG2755	lipolytic protein G-D-S-L family
A0R60_RS09970	COG0300	oxidoreductase activity
A0R60_RS09975	COG3118	belongs to the thioredoxin family
A0R60_RS09980	COG0390	transport system, permease component
A0R60_RS09985	COG4619	ABC transporter
A0R60_RS09995	COG0330	HflC and HflK could
A0R60_RS10000	COG1585	Membrane protein implicated in regulation of membrane protease activity
A0R60_RS10010	COG2217	Heavy metal translocating P-type atpase
A0R60_RS10015	COG3735	TraB family
A0R60_RS10020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A0R60_RS10025	COG0737	Belongs to the 5'-nucleotidase family
A0R60_RS10030	COG2223	nitrite transmembrane transporter activity
A0R60_RS10035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A0R60_RS10035	COG4651	solute:proton antiporter activity
A0R60_RS10040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A0R60_RS10045	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A0R60_RS10055	COG0326	Molecular chaperone. Has ATPase activity
A0R60_RS10060	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A0R60_RS10065	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A0R60_RS10075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A0R60_RS10080	COG2832	Protein of unknown function (DUF454)
A0R60_RS10085	COG3923	Primosomal replication protein n
A0R60_RS10095	COG1196	nuclear chromosome segregation
A0R60_RS10095	COG3264	Mechanosensitive ion channel
A0R60_RS10100	COG1309	transcriptional regulator
A0R60_RS10110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A0R60_RS10125	COG0110	maltose O-acetyltransferase activity
A0R60_RS10145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A0R60_RS10155	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A0R60_RS10180	COG2364	Membrane
A0R60_RS10185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0R60_RS10215	COG0582	viral genome integration into host DNA
A0R60_RS10225	COG3695	enzyme binding
A0R60_RS10230	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A0R60_RS10235	COG1946	Acyl-CoA thioesterase
A0R60_RS10240	COG0004	ammonium transporteR
A0R60_RS10245	COG0347	Belongs to the P(II) protein family
A0R60_RS10250	COG1132	(ABC) transporter
A0R60_RS10260	COG1522	sequence-specific DNA binding
A0R60_RS10270	COG0561	phosphatase activity
A0R60_RS10280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A0R60_RS10290	COG3657	addiction module killer protein
A0R60_RS10295	COG0824	Thioesterase
A0R60_RS10300	COG1555	photosystem II stabilization
A0R60_RS10305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A0R60_RS10310	COG0776	regulation of translation
A0R60_RS10320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A0R60_RS10330	COG0544	peptidyl-prolyl cis-trans isomerase activity
A0R60_RS10335	COG0271	Belongs to the BolA IbaG family
A0R60_RS10340	COG3056	Lipoprotein
A0R60_RS10345	COG2223	nitrite transmembrane transporter activity
A0R60_RS10350	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A0R60_RS10360	COG1845	cytochrome c oxidase, subunit III
A0R60_RS10365	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A0R60_RS10370	COG0109	protoheme IX farnesyltransferase activity
A0R60_RS10375	COG2814	Major facilitator Superfamily
A0R60_RS10385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A0R60_RS10390	COG0693	protein deglycase activity
A0R60_RS10405	COG0142	geranyltranstransferase activity
A0R60_RS10410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A0R60_RS10415	COG0667	Aldo Keto reductase
A0R60_RS10420	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A0R60_RS10425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A0R60_RS10430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A0R60_RS10435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A0R60_RS10435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A0R60_RS10440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A0R60_RS10445	COG4238	major outer membrane lipoprotein
A0R60_RS10465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A0R60_RS10470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A0R60_RS10475	COG1862	Preprotein translocase
A0R60_RS10490	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A0R60_RS10495	COG0450	alkyl hydroperoxide reductase
A0R60_RS10510	COG0366	Alpha amylase catalytic
A0R60_RS10535	COG0420	3'-5' exonuclease activity
A0R60_RS10540	COG0419	ATPase involved in DNA repair
A0R60_RS10545	COG1940	carbohydrate kinase activity
A0R60_RS10555	COG3123	guanosine phosphorylase activity
A0R60_RS10560	COG4126	flavin adenine dinucleotide binding
A0R60_RS10570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A0R60_RS10575	COG1671	Belongs to the UPF0178 family
A0R60_RS10580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A0R60_RS10585	COG3706	GGDEF domain
A0R60_RS10595	COG1785	Belongs to the alkaline phosphatase family
A0R60_RS10615	COG1181	Belongs to the D-alanine--D-alanine ligase family
A0R60_RS10635	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A0R60_RS10645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A0R60_RS10655	COG3468	outer membrane autotransporter barrel domain protein
A0R60_RS10660	COG0113	porphobilinogen synthase activity
A0R60_RS10670	COG2175	clavaminate synthase activity
A0R60_RS10675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A0R60_RS10685	COG4521	taurine ABC transporter
A0R60_RS10690	COG2040	homocysteine
A0R60_RS10695	COG0833	amino acid
A0R60_RS10710	COG2826	transposase and inactivated derivatives, IS30 family
A0R60_RS10715	COG2963	transposase activity
A0R60_RS10720	COG0583	DNA-binding transcription factor activity
A0R60_RS10725	COG0667	Aldo Keto reductase
A0R60_RS10740	COG0667	Aldo Keto reductase
A0R60_RS10750	COG1764	response to oxidative stress
A0R60_RS10760	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS10785	COG4221	oxidoreductase activity
A0R60_RS10840	COG4983	Phage plasmid primase, P4 family domain protein
A0R60_RS10900	COG3596	GTP binding
A0R60_RS10915	COG2003	Belongs to the UPF0758 family
A0R60_RS10945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A0R60_RS10950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A0R60_RS10960	COG1073	alpha beta
A0R60_RS10970	COG2195	Cleaves the N-terminal amino acid of tripeptides
A0R60_RS10975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A0R60_RS10980	COG2991	Protein conserved in bacteria
A0R60_RS10995	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A0R60_RS11000	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A0R60_RS11015	COG3034	peptidoglycan biosynthetic process
A0R60_RS11020	COG0121	glutamine amidotransferase
A0R60_RS11030	COG1960	acyl-CoA dehydrogenase activity
A0R60_RS11035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A0R60_RS11045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0R60_RS11065	COG0444	Belongs to the ABC transporter superfamily
A0R60_RS11090	COG2226	methyltransferase
A0R60_RS11095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0R60_RS11100	COG1388	LysM domain
A0R60_RS11100	COG0741	lytic transglycosylase activity
A0R60_RS11105	COG2226	methyltransferase
A0R60_RS11110	COG3021	interspecies interaction between organisms
A0R60_RS11115	COG2814	Major facilitator Superfamily
A0R60_RS11160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A0R60_RS11170	COG2011	ABC-type metal ion transport system permease component
A0R60_RS11175	COG1464	Belongs to the NlpA lipoprotein family
A0R60_RS11185	COG1720	tRNA m6t6A37 methyltransferase activity
A0R60_RS11195	COG3015	lipoprotein NlpE involved in copper resistance
A0R60_RS11200	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A0R60_RS11215	COG4568	rho-dependent transcription termination
A0R60_RS11225	COG0346	lactoylglutathione lyase activity
A0R60_RS11230	COG1982	Orn Lys Arg decarboxylase major
A0R60_RS11245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A0R60_RS11250	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0R60_RS11255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0R60_RS11260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A0R60_RS11265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0R60_RS11275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A0R60_RS11280	COG0750	zinc metalloprotease
A0R60_RS11285	COG0575	Belongs to the CDS family
A0R60_RS11310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A0R60_RS11340	COG3835	regulator
A0R60_RS11350	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A0R60_RS11355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A0R60_RS11370	COG0316	Belongs to the HesB IscA family
A0R60_RS11385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0R60_RS11390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A0R60_RS11395	COG1120	ATPase activity
A0R60_RS11415	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A0R60_RS11420	COG1489	DNA binding
A0R60_RS11430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0R60_RS11435	COG0617	tRNA 3'-terminal CCA addition
A0R60_RS11440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A0R60_RS11445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A0R60_RS11450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A0R60_RS11455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A0R60_RS11460	COG0726	polysaccharide deacetylase
A0R60_RS11465	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0R60_RS11470	COG0842	Transport permease protein
A0R60_RS11475	COG1131	(ABC) transporter
A0R60_RS11480	COG0288	reversible hydration of carbon dioxide
A0R60_RS11490	COG4993	Dehydrogenase
A0R60_RS11505	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A0R60_RS11510	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A0R60_RS11520	COG1049	propionate catabolic process, 2-methylcitrate cycle
A0R60_RS11525	COG3064	Membrane
A0R60_RS11535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0R60_RS11540	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0R60_RS11545	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A0R60_RS11550	COG2186	Transcriptional regulator
A0R60_RS11560	COG1113	amino acid transport
A0R60_RS11570	COG3940	Belongs to the glycosyl hydrolase 43 family
A0R60_RS11575	COG3725	Membrane protein required for beta-lactamase induction
A0R60_RS11580	COG3023	N-Acetylmuramoyl-L-alanine amidase
A0R60_RS11590	COG4969	Belongs to the N-Me-Phe pilin family
A0R60_RS11600	COG1459	type II secretion system
A0R60_RS11605	COG0516	GMP reductase activity
A0R60_RS11620	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A0R60_RS11625	COG0494	nUDIX hydrolase
A0R60_RS11630	COG0653	protein targeting
A0R60_RS11640	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A0R60_RS11645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A0R60_RS11660	COG1181	Belongs to the D-alanine--D-alanine ligase family
A0R60_RS11675	COG0772	Belongs to the SEDS family
A0R60_RS11685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0R60_RS11690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A0R60_RS11695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A0R60_RS11700	COG0768	penicillin binding
A0R60_RS11715	COG2001	Belongs to the MraZ family
A0R60_RS11720	COG1609	Transcriptional regulator
A0R60_RS11725	COG0440	acetolactate synthase activity
A0R60_RS11730	COG0028	Belongs to the TPP enzyme family
A0R60_RS11765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A0R60_RS11775	COG2814	Major facilitator Superfamily
A0R60_RS11795	COG1178	ABC-type Fe3 transport system permease component
A0R60_RS11805	COG0586	Pfam SNARE associated Golgi protein
A0R60_RS11815	COG1069	ribulokinase activity
A0R60_RS11820	COG2160	L-arabinose isomerase activity
A0R60_RS11825	COG0235	Class ii aldolase
A0R60_RS11830	COG0417	DNA replication proofreading
A0R60_RS11840	COG0564	pseudouridine synthase activity
A0R60_RS11845	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A0R60_RS11860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A0R60_RS11870	COG2967	ApaG domain
A0R60_RS11875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A0R60_RS11885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A0R60_RS11885	COG0475	glutathione-regulated potassium exporter activity
A0R60_RS11890	COG2249	NAD(P)H dehydrogenase (quinone) activity
A0R60_RS11920	COG1047	Peptidyl-prolyl cis-trans
A0R60_RS11935	COG0196	riboflavin kinase activity
A0R60_RS11945	COG0268	Binds directly to 16S ribosomal RNA
A0R60_RS11950	COG0583	DNA-binding transcription factor activity
A0R60_RS11955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A0R60_RS11970	COG1584	GPR1 FUN34 yaaH family protein
A0R60_RS11980	COG0521	Mo-molybdopterin cofactor biosynthetic process
A0R60_RS11990	COG1115	amino acid carrier protein
A0R60_RS11995	COG3022	response to hydroperoxide
A0R60_RS12005	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A0R60_RS12025	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A0R60_RS12035	COG0745	RESPONSE REGULATOR receiver
A0R60_RS12040	COG3045	CreA protein
A0R60_RS12045	COG2207	Transcriptional regulator
A0R60_RS12045	COG3708	Transcriptional regulator
A0R60_RS12050	COG0406	alpha-ribazole phosphatase activity
A0R60_RS12055	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A0R60_RS12060	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
A0R60_RS12065	COG0741	lytic transglycosylase activity
A0R60_RS12070	COG0488	(ABC) transporter
A0R60_RS12080	COG0604	alcohol dehydrogenase
A0R60_RS12095	COG0560	Phosphoserine phosphatase
A0R60_RS12100	COG3726	membrane protein affecting hemolysin expression
A0R60_RS12110	COG0813	purine-nucleoside phosphorylase activity
A0R60_RS12120	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A0R60_RS12130	COG1328	CTP reductase activity
A0R60_RS12135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A0R60_RS12140	COG0084	hydrolase, TatD family'
A0R60_RS12145	COG4667	esterase of the alpha-beta hydrolase superfamily
A0R60_RS12150	COG5487	UPF0391 membrane protein
A0R60_RS12155	COG2823	Periplasmic or secreted lipoprotein
A0R60_RS12160	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A0R60_RS12165	COG1011	Hydrolase
A0R60_RS12170	COG0456	acetyltransferase
A0R60_RS12175	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A0R60_RS12180	COG2813	Specifically methylates the guanine in position
A0R60_RS12210	COG4114	ferric iron reductase
A0R60_RS12215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A0R60_RS12220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A0R60_RS12225	COG2197	response regulator
A0R60_RS12230	COG2197	response regulator
A0R60_RS12235	COG2966	Psort location CytoplasmicMembrane, score
A0R60_RS12240	COG3610	response to peptide
A0R60_RS12245	COG1309	transcriptional regulator
A0R60_RS12250	COG1846	Transcriptional regulator
A0R60_RS12255	COG1764	response to oxidative stress
A0R60_RS12265	COG1484	DNA-dependent DNA replication
A0R60_RS12330	COG1846	Transcriptional regulator
A0R60_RS12335	COG0179	Fumarylacetoacetate (FAA) hydrolase
A0R60_RS12340	COG1012	belongs to the aldehyde dehydrogenase family
A0R60_RS12345	COG3384	dioxygenase
A0R60_RS12355	COG3971	2-oxopent-4-enoate hydratase activity
A0R60_RS12375	COG2368	4-hydroxyphenylacetate
A0R60_RS12380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A0R60_RS12390	COG1966	Carbon starvation protein
A0R60_RS12395	COG2879	small protein
A0R60_RS12400	COG0523	cobalamin synthesis protein
A0R60_RS12420	COG1012	belongs to the aldehyde dehydrogenase family
A0R60_RS12435	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A0R60_RS12495	COG1414	Transcriptional regulator
A0R60_RS12500	COG3507	Belongs to the glycosyl hydrolase 43 family
A0R60_RS12505	COG2211	Major facilitator Superfamily
A0R60_RS12510	COG0129	dihydroxy-acid dehydratase activity
A0R60_RS12515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0R60_RS12520	COG2731	YhcH YjgK YiaL family protein
A0R60_RS12525	COG2235	arginine
A0R60_RS12540	COG1288	antiporter activity
A0R60_RS12545	COG1438	arginine binding
A0R60_RS12560	COG0540	Belongs to the ATCase OTCase family
A0R60_RS12570	COG0251	oxidation-reduction process
A0R60_RS12585	COG1609	Transcriptional regulator
A0R60_RS12590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0R60_RS12590	COG1263	PTS System
A0R60_RS12605	COG0602	queuosine metabolic process
A0R60_RS12610	COG2026	Addiction module toxin, RelE StbE family
A0R60_RS12615	COG3077	Addiction module antitoxin, RelB DinJ family
A0R60_RS12620	COG3711	transcriptional antiterminator
A0R60_RS12620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0R60_RS12640	COG3964	amidohydrolase
A0R60_RS12675	COG0312	modulator of DNA gyrase
A0R60_RS12680	COG3028	Belongs to the UPF0307 family
A0R60_RS12685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A0R60_RS12695	COG0583	DNA-binding transcription factor activity
A0R60_RS12705	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0R60_RS12710	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0R60_RS12715	COG1129	ABC transporter
A0R60_RS12720	COG1879	ABC-type sugar transport system periplasmic component
A0R60_RS12745	COG2105	PFAM AIG2 family protein
A0R60_RS12750	COG2911	Protein conserved in bacteria
A0R60_RS12760	COG0729	surface antigen
A0R60_RS12765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0R60_RS12770	COG1253	flavin adenine dinucleotide binding
A0R60_RS12780	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A0R60_RS12785	COG1218	3'(2'),5'-bisphosphate nucleotidase
A0R60_RS12795	COG1733	regulation of RNA biosynthetic process
A0R60_RS12810	COG1917	Cupin 2, conserved barrel domain protein
A0R60_RS12810	COG4977	sequence-specific DNA binding
A0R60_RS12820	COG0697	spore germination
A0R60_RS12825	COG0840	transmembrane signaling receptor activity
A0R60_RS12835	COG1113	amino acid transport
A0R60_RS12840	COG0545	Peptidyl-prolyl cis-trans isomerase
A0R60_RS12845	COG3061	Opacity-associated protein A
A0R60_RS12850	COG0359	binds to the 23S rRNA
A0R60_RS12855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A0R60_RS12860	COG2965	DNA replication, synthesis of RNA primer
A0R60_RS12880	COG3650	response to hydrogen peroxide
A0R60_RS12895	COG1960	acyl-CoA dehydrogenase activity
A0R60_RS12905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A0R60_RS12915	COG1959	2 iron, 2 sulfur cluster binding
A0R60_RS12925	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A0R60_RS12930	COG0330	HflC and HflK could
A0R60_RS12935	COG0330	HflC and HflK could
A0R60_RS12945	COG1923	regulation of RNA biosynthetic process
A0R60_RS12950	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A0R60_RS12965	COG0802	atpase or kinase
A0R60_RS12970	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A0R60_RS12970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A0R60_RS12975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A0R60_RS12995	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A0R60_RS13010	COG1511	domain protein
A0R60_RS13010	COG3264	Mechanosensitive ion channel
A0R60_RS13020	COG1053	succinate dehydrogenase
A0R60_RS13025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A0R60_RS13040	COG0583	DNA-binding transcription factor activity
A0R60_RS13070	COG5510	response to toxic substance
A0R60_RS13090	COG0459	protein refolding
A0R60_RS13100	COG0531	amino acid
A0R60_RS13105	COG3030	protein affecting phage T7 exclusion by the F plasmid
A0R60_RS13115	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A0R60_RS13130	COG1309	transcriptional regulator
A0R60_RS13150	COG0582	viral genome integration into host DNA
A0R60_RS13230	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A0R60_RS13255	COG2824	Alkylphosphonate utilization operon protein PhnA
A0R60_RS13270	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A0R60_RS13275	COG3639	organic phosphonate transmembrane transporter activity
A0R60_RS13280	COG2188	Transcriptional regulator
A0R60_RS13285	COG3624	Phosphonate C-P lyase system protein PhnG
A0R60_RS13290	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
A0R60_RS13295	COG3626	phosphonate metabolism
A0R60_RS13300	COG3627	carbon phosphorus lyase activity
A0R60_RS13305	COG4107	phosphonate C-P lyase system protein PhnK
A0R60_RS13310	COG4778	phosphonate C-P lyase system protein PhnL
A0R60_RS13315	COG3454	Phosphonate metabolism
A0R60_RS13320	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A0R60_RS13325	COG0456	acetyltransferase
A0R60_RS13330	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A0R60_RS13340	COG4191	Histidine kinase
A0R60_RS13340	COG0784	Response regulator, receiver
A0R60_RS13350	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0R60_RS13365	COG0191	fructose-bisphosphate aldolase activity
A0R60_RS13395	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A0R60_RS13400	COG1301	dicarboxylic acid transport
A0R60_RS13405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A0R60_RS13410	COG3162	membrane
A0R60_RS13415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A0R60_RS13420	COG1346	cytolysis
A0R60_RS13425	COG1380	Effector of murein hydrolase LrgA
A0R60_RS13435	COG0025	NhaP-type Na H and K H
A0R60_RS13440	COG2252	PERMEase
A0R60_RS13450	COG0789	Transcriptional regulator
A0R60_RS13460	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A0R60_RS13470	COG0629	single-stranded DNA binding
A0R60_RS13485	COG2315	Protein conserved in bacteria
A0R60_RS13495	COG3700	Belongs to the class B bacterial acid phosphatase family
A0R60_RS13520	COG0305	Participates in initiation and elongation during chromosome replication
A0R60_RS13525	COG0604	alcohol dehydrogenase
A0R60_RS13535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A0R60_RS13550	COG0735	belongs to the Fur family
A0R60_RS13555	COG3237	CsbD-like
A0R60_RS13560	COG0534	Mate efflux family protein
A0R60_RS13565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A0R60_RS13570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A0R60_RS13575	COG2937	Belongs to the GPAT DAPAT family
A0R60_RS13580	COG2610	gluconate transmembrane transporter activity
A0R60_RS13590	COG1609	Transcriptional regulator
A0R60_RS13595	COG1741	Belongs to the pirin family
A0R60_RS13600	COG0673	inositol 2-dehydrogenase activity
A0R60_RS13605	COG1247	-acetyltransferase
A0R60_RS13610	COG0405	Gamma-glutamyltransferase
A0R60_RS13620	COG0584	glycerophosphoryl diester phosphodiesterase
A0R60_RS13665	COG0683	leucine binding
A0R60_RS13685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A0R60_RS13690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A0R60_RS13695	COG2177	Part of the ABC transporter FtsEX involved in
A0R60_RS13700	COG2884	Cell division ATP-binding protein ftsE
A0R60_RS13705	COG0552	protein localization to endoplasmic reticulum
A0R60_RS13710	COG0742	ribosomal rna small subunit methyltransferase
A0R60_RS13715	COG3776	membrane
A0R60_RS13725	COG3714	YhhN family
A0R60_RS13735	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A0R60_RS13740	COG3161	chorismate lyase activity
A0R60_RS13760	COG4580	involved in the transport of maltose and maltodextrins
A0R60_RS13785	COG3223	Belongs to the PsiE family
A0R60_RS13795	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A0R60_RS13820	COG0527	aspartate kinase activity
A0R60_RS13835	COG1187	pseudouridine synthase activity
A0R60_RS13865	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A0R60_RS13875	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A0R60_RS13910	COG0151	Belongs to the GarS family
A0R60_RS13925	COG3068	Protein conserved in bacteria
A0R60_RS13935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A0R60_RS13945	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A0R60_RS13960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A0R60_RS13965	COG2104	thiamine diphosphate biosynthetic process
A0R60_RS13970	COG2022	thiamine diphosphate biosynthetic process
A0R60_RS13975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A0R60_RS13980	COG3706	GGDEF domain
A0R60_RS14025	COG0250	Participates in transcription elongation, termination and antitermination
A0R60_RS14065	COG4608	Belongs to the ABC transporter superfamily
A0R60_RS14070	COG0444	Belongs to the ABC transporter superfamily
A0R60_RS14075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0R60_RS14080	COG0601	transmembrane transport
A0R60_RS14095	COG2194	sulfuric ester hydrolase activity
A0R60_RS14100	COG2223	nitrite transmembrane transporter activity
A0R60_RS14110	COG5571	outer membrane autotransporter
A0R60_RS14115	COG2818	Glycosylase
A0R60_RS14120	COG0456	acetyltransferase
A0R60_RS14130	COG2885	chlorophyll binding
A0R60_RS14135	COG1609	Transcriptional regulator
A0R60_RS14145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A0R60_RS14155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A0R60_RS14160	COG1278	Cold shock
A0R60_RS14170	COG2944	sequence-specific DNA binding
A0R60_RS14175	COG0488	(ABC) transporter
A0R60_RS14180	COG0751	glycine-tRNA ligase activity
A0R60_RS14185	COG0752	glycyl-tRNA synthetase alpha subunit
A0R60_RS14195	COG3274	enterobacterial common antigen metabolic process
A0R60_RS14200	COG2169	Transcriptional regulator
A0R60_RS14205	COG1335	isochorismatase
A0R60_RS14210	COG1070	Carbohydrate kinase
A0R60_RS14215	COG2115	Belongs to the xylose isomerase family
A0R60_RS14225	COG4213	ABC transporter substrate-binding protein
A0R60_RS14235	COG4214	carbohydrate transport
A0R60_RS14240	COG2207	Transcriptional regulator
A0R60_RS14240	COG1609	Transcriptional regulator
A0R60_RS14250	COG0366	Alpha amylase catalytic
A0R60_RS14260	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A0R60_RS14265	COG3713	MltA-interacting MipA family protein
A0R60_RS14270	COG0583	DNA-binding transcription factor activity
A0R60_RS14275	COG1012	belongs to the aldehyde dehydrogenase family
A0R60_RS14280	COG1940	carbohydrate kinase activity
A0R60_RS14285	COG3276	selenocysteine insertion sequence binding
A0R60_RS14295	COG0625	glutathione transferase activity
A0R60_RS14310	COG2213	PTS system mannitol-specific
A0R60_RS14310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0R60_RS14320	COG3722	fumarate hydratase activity
A0R60_RS14330	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A0R60_RS14350	COG2186	Transcriptional regulator
A0R60_RS14365	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A0R60_RS14375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A0R60_RS14380	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A0R60_RS14385	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A0R60_RS14390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A0R60_RS14405	COG2861	carbohydrate metabolic process
A0R60_RS14410	COG0463	Glycosyl transferase, family 2
A0R60_RS14425	COG1063	alcohol dehydrogenase
A0R60_RS14445	COG0859	PFAM glycosyl transferase family 9
A0R60_RS14455	COG0463	Glycosyl transferase, family 2
A0R60_RS14470	COG0859	PFAM glycosyl transferase family 9
A0R60_RS14480	COG0438	transferase activity, transferring glycosyl groups
A0R60_RS14500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A0R60_RS14505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A0R60_RS14510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A0R60_RS14515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A0R60_RS14520	COG2003	Belongs to the UPF0758 family
A0R60_RS14525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A0R60_RS14540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A0R60_RS14550	COG1561	YicC-like family, N-terminal region
A0R60_RS14555	COG2860	membrane
A0R60_RS14560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A0R60_RS14575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A0R60_RS14580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A0R60_RS14590	COG0786	glutamate:sodium symporter activity
A0R60_RS14595	COG2233	PERMEase
A0R60_RS14605	COG1501	Belongs to the glycosyl hydrolase 31 family
A0R60_RS14610	COG2211	Major facilitator Superfamily
A0R60_RS14660	COG3121	Chaperone
A0R60_RS14685	COG0789	Transcriptional regulator
A0R60_RS14695	COG3272	Protein of unknown function (DUF1722)
A0R60_RS14700	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A0R60_RS14720	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A0R60_RS14725	COG1464	Belongs to the NlpA lipoprotein family
A0R60_RS14730	COG0454	-acetyltransferase
A0R60_RS14760	COG1609	Transcriptional regulator
A0R60_RS14770	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A0R60_RS14770	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A0R60_RS14780	COG1447	Phosphotransferase system cellobiose-specific component IIA
A0R60_RS14785	COG4580	involved in the transport of maltose and maltodextrins
A0R60_RS14790	COG0697	spore germination
A0R60_RS14820	COG2197	response regulator
A0R60_RS14825	COG0440	acetolactate synthase activity
A0R60_RS14855	COG2814	Major facilitator Superfamily
A0R60_RS14865	COG0583	DNA-binding transcription factor activity
A0R60_RS14870	COG2610	gluconate transmembrane transporter activity
A0R60_RS14885	COG2149	membrane
A0R60_RS14900	COG2188	Transcriptional regulator
A0R60_RS14910	COG0071	Belongs to the small heat shock protein (HSP20) family
A0R60_RS14920	COG5645	(Lipo)protein
A0R60_RS14925	COG0823	Involved in the tonB-independent uptake of proteins
A0R60_RS14935	COG4948	Mandelate Racemase Muconate Lactonizing
A0R60_RS14940	COG0800	Aldolase
A0R60_RS14945	COG3734	2-keto-3-deoxy-galactonokinase
A0R60_RS14950	COG2186	Transcriptional regulator
A0R60_RS14980	COG0592	DNA-directed DNA polymerase activity
A0R60_RS15005	COG0706	membrane insertase activity
A0R60_RS15010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A0R60_RS15030	COG0431	NADPH-dependent FMN reductase
A0R60_RS15035	COG2252	PERMEase
A0R60_RS15045	COG0704	Plays a role in the regulation of phosphate uptake
A0R60_RS15050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A0R60_RS15060	COG0573	inorganic phosphate transmembrane transporter activity
A0R60_RS15065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A0R60_RS15075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A0R60_RS15080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A0R60_RS15085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A0R60_RS15095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A0R60_RS15100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A0R60_RS15105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A0R60_RS15115	COG0356	it plays a direct role in the translocation of protons across the membrane
A0R60_RS15120	COG3312	ion transport
A0R60_RS15130	COG0445	tRNA wobble uridine modification
A0R60_RS15135	COG0716	FMN binding
A0R60_RS15140	COG1522	sequence-specific DNA binding
A0R60_RS15145	COG2502	aspartate--ammonia ligase
A0R60_RS15150	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A0R60_RS15160	COG3158	transport of potassium into the cell
A0R60_RS15165	COG1869	D-ribose catabolic process
A0R60_RS15175	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0R60_RS15180	COG1879	ABC-type sugar transport system periplasmic component
A0R60_RS15185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A0R60_RS15190	COG1609	Transcriptional regulator
A0R60_RS15195	COG0477	Major facilitator Superfamily
A0R60_RS15200	COG2186	Transcriptional regulator
A0R60_RS15225	COG1763	Mo-molybdopterin cofactor biosynthetic process
A0R60_RS15230	COG0746	molybdenum cofactor guanylyltransferase activity
A0R60_RS15235	COG3084	Protein conserved in bacteria
A0R60_RS15240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A0R60_RS15250	COG0204	Acyl-transferase
A0R60_RS15270	COG3078	GTPase activator activity
A0R60_RS15275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A0R60_RS15290	COG3852	Histidine kinase
A0R60_RS15330	COG1011	Hydrolase
A0R60_RS15355	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A0R60_RS15365	COG3058	Necessary for formate dehydrogenase activity
A0R60_RS15370	COG2864	formate dehydrogenase
A0R60_RS15375	COG0437	4 iron, 4 sulfur cluster binding
A0R60_RS15400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A0R60_RS15425	COG3254	rhamnose metabolic process
A0R60_RS15430	COG1454	alcohol dehydrogenase
A0R60_RS15435	COG0235	Class ii aldolase
A0R60_RS15440	COG4806	L-rhamnose isomerase
A0R60_RS15445	COG1070	Carbohydrate kinase
A0R60_RS15450	COG4977	sequence-specific DNA binding
A0R60_RS15455	COG1917	Cupin 2, conserved barrel domain protein
A0R60_RS15455	COG4977	sequence-specific DNA binding
A0R60_RS15465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A0R60_RS15470	COG2258	MOSC domain
A0R60_RS15475	COG2205	protein histidine kinase activity
A0R60_RS15480	COG0745	RESPONSE REGULATOR receiver
A0R60_RS15485	COG3678	ATP-independent chaperone mediated protein folding
A0R60_RS15495	COG0205	6-phosphofructokinase activity
A0R60_RS15505	COG2134	cdp-diacylglycerol pyrophosphatase
A0R60_RS15515	COG0149	triose-phosphate isomerase activity
A0R60_RS15525	COG3152	Membrane
A0R60_RS15535	COG1494	fructose-1,6-bisphosphatase
A0R60_RS15540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A0R60_RS15550	COG3074	FtsZ-dependent cytokinesis
A0R60_RS15560	COG1575	Belongs to the MenA family. Type 1 subfamily
A0R60_RS15575	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A0R60_RS15580	COG1609	Transcriptional regulator
A0R60_RS15585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A0R60_RS15590	COG0254	rRNA binding
A0R60_RS15600	COG0626	cystathionine gamma-synthase activity
A0R60_RS15605	COG0460	homoserine dehydrogenase
A0R60_RS15605	COG0527	aspartate kinase activity
A0R60_RS15610	COG0165	Argininosuccinate lyase
A0R60_RS15620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A0R60_RS15625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A0R60_RS15635	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A0R60_RS15640	COG0371	Dehydrogenase
A0R60_RS15650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0R60_RS15650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A0R60_RS15650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0R60_RS15655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0R60_RS15660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0R60_RS15665	COG1882	Formate acetyltransferase
A0R60_RS15670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A0R60_RS15675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0R60_RS15680	COG2207	Transcriptional regulator
A0R60_RS15685	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A0R60_RS15690	COG0583	DNA-binding transcription factor activity
A0R60_RS15710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A0R60_RS15715	COG4206	TonB-dependent receptor
A0R60_RS15765	COG3085	chromosome segregation
A0R60_RS15785	COG3978	acetolactate synthase activity
A0R60_RS15790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A0R60_RS15800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A0R60_RS15815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A0R60_RS15820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A0R60_RS15840	COG3118	belongs to the thioredoxin family
A0R60_RS15845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A0R60_RS15850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0R60_RS15865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A0R60_RS15870	COG0456	acetyltransferase
A0R60_RS15875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A0R60_RS15880	COG2244	polysaccharide biosynthetic process
A0R60_RS15895	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A0R60_RS15930	COG3071	HemY protein
A0R60_RS15935	COG2959	enzyme of heme biosynthesis
A0R60_RS15985	COG1011	Hydrolase
A0R60_RS16025	COG1280	lysine exporter protein (LysE YggA)
A0R60_RS16030	COG1280	lysine exporter protein (LysE YggA)
A0R60_RS16035	COG2267	carboxylic ester hydrolase activity
A0R60_RS16045	COG0697	spore germination
A0R60_RS16050	COG0583	DNA-binding transcription factor activity
A0R60_RS16065	COG0412	Dienelactone hydrolase
A0R60_RS16075	COG1322	Protein conserved in bacteria
A0R60_RS16080	COG2226	methyltransferase
A0R60_RS16095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A0R60_RS16105	COG0805	protein transport
A0R60_RS16110	COG0084	hydrolase, TatD family'
A0R60_RS16120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A0R60_RS16135	COG1250	3-hydroxyacyl-CoA dehydrogenase
A0R60_RS16135	COG1024	Enoyl-CoA hydratase
A0R60_RS16145	COG0006	proline dipeptidase activity
A0R60_RS16150	COG1739	Uncharacterized protein family UPF0029
A0R60_RS16190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A0R60_RS16205	COG2194	sulfuric ester hydrolase activity
A0R60_RS16230	COG1215	transferase activity, transferring glycosyl groups
A0R60_RS16235	COG1215	transferase activity, transferring glycosyl groups
A0R60_RS16240	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A0R60_RS16245	COG3118	belongs to the thioredoxin family
A0R60_RS16245	COG0457	Tetratricopeptide repeat
A0R60_RS16255	COG1301	dicarboxylic acid transport
A0R60_RS16260	COG0612	Peptidase, M16
A0R60_RS16280	COG0477	Major facilitator Superfamily
A0R60_RS16285	COG1295	ribonuclease BN
A0R60_RS16295	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS16305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A0R60_RS16325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A0R60_RS16330	COG0339	signal peptide processing
A0R60_RS16335	COG0742	ribosomal rna small subunit methyltransferase
A0R60_RS16340	COG0589	response to stress
A0R60_RS16360	COG2081	HI0933 family
A0R60_RS16435	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0R60_RS16465	COG0739	heme binding
A0R60_RS16475	COG2132	Multicopper oxidase
A0R60_RS16480	COG3667	copper resistance
A0R60_RS16485	COG2372	response to copper ion
A0R60_RS16490	COG1276	copper resistance
A0R60_RS16495	COG0745	RESPONSE REGULATOR receiver
A0R60_RS16500	COG2205	protein histidine kinase activity
A0R60_RS16510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A0R60_RS16515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A0R60_RS16520	COG1414	Transcriptional regulator
A0R60_RS16545	COG0791	NLP P60 protein
A0R60_RS16550	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS16560	COG3479	Phenolic acid decarboxylase
A0R60_RS16605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0R60_RS16610	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS16620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0R60_RS16645	COG1216	Glycosyl transferase, family 2
A0R60_RS16655	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A0R60_RS16655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A0R60_RS16665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A0R60_RS16695	COG0628	permease
A0R60_RS16700	COG0477	Major facilitator Superfamily
A0R60_RS16710	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A0R60_RS16715	COG0425	Belongs to the sulfur carrier protein TusA family
A0R60_RS16720	COG2095	MarC family integral membrane protein
A0R60_RS16725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A0R60_RS16730	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A0R60_RS16735	COG1523	belongs to the glycosyl hydrolase 13 family
A0R60_RS16745	COG0297	glycogen (starch) synthase activity
A0R60_RS16750	COG0058	SHG alpha-glucan phosphorylase activity
A0R60_RS16760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A0R60_RS16765	COG0705	Rhomboid family
A0R60_RS16770	COG1349	DNA-binding transcription factor activity
A0R60_RS16775	COG2909	trisaccharide binding
A0R60_RS16780	COG0058	SHG alpha-glucan phosphorylase activity
A0R60_RS16785	COG1640	4-alpha-glucanotransferase
A0R60_RS16790	COG2610	gluconate transmembrane transporter activity
A0R60_RS16825	COG1918	ferrous iron import across plasma membrane
A0R60_RS16830	COG2183	response to ionizing radiation
A0R60_RS16850	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A0R60_RS16855	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A0R60_RS16860	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A0R60_RS16865	COG1011	Hydrolase
A0R60_RS16880	COG0494	nUDIX hydrolase
A0R60_RS16885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A0R60_RS16890	COG4972	Pilus assembly protein
A0R60_RS16920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A0R60_RS16930	COG3266	domain, Protein
A0R60_RS16935	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A0R60_RS16940	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A0R60_RS16950	COG0180	Tryptophanyl-tRNA synthetase
A0R60_RS16960	COG1648	precorrin-2 dehydrogenase activity
A0R60_RS16960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A0R60_RS16970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A0R60_RS16975	COG0402	S-adenosylhomocysteine deaminase activity
A0R60_RS16990	COG2184	nucleotidyltransferase activity
A0R60_RS17005	COG1289	transmembrane transporter activity
A0R60_RS17015	COG1765	OsmC-like protein
A0R60_RS17020	COG3954	Phosphoribulokinase
A0R60_RS17025	COG3089	Belongs to the UPF0270 family
A0R60_RS17030	COG0429	hydrolase of the alpha beta-hydrolase fold
A0R60_RS17035	COG0488	(ABC) transporter
A0R60_RS17045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A0R60_RS17045	COG0475	glutathione-regulated potassium exporter activity
A0R60_RS17050	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A0R60_RS17055	COG1047	Peptidyl-prolyl cis-trans
A0R60_RS17065	COG0545	Peptidyl-prolyl cis-trans isomerase
A0R60_RS17070	COG2964	Protein conserved in bacteria
A0R60_RS17075	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A0R60_RS17080	COG2923	Belongs to the DsrF TusC family
A0R60_RS17085	COG2168	tRNA wobble position uridine thiolation
A0R60_RS17125	COG0051	transcription antitermination factor activity, RNA binding
A0R60_RS17165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A0R60_RS17200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A0R60_RS17205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A0R60_RS17220	COG1841	ribosomal large subunit assembly
A0R60_RS17230	COG0201	protein transport
A0R60_RS17245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A0R60_RS17255	COG0202	RNA polymerase activity
A0R60_RS17270	COG0789	Transcriptional regulator
A0R60_RS17275	COG3036	rescue of stalled ribosome
A0R60_RS17295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A0R60_RS17300	COG0242	peptide deformylase activity
A0R60_RS17305	COG0758	DNA mediated transformation
A0R60_RS17310	COG2922	Belongs to the Smg family
A0R60_RS17315	COG0551	DNA topoisomerase type I activity
A0R60_RS17320	COG0009	L-threonylcarbamoyladenylate synthase
A0R60_RS17325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A0R60_RS17335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A0R60_RS17370	COG1126	abc transporter atp-binding protein
A0R60_RS17375	COG0765	amino acid transport
A0R60_RS17385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0R60_RS17395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A0R60_RS17400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0R60_RS17405	COG1309	transcriptional regulator
A0R60_RS17440	COG4145	pantothenate transmembrane transporter activity
A0R60_RS17445	COG3924	membrane
A0R60_RS17450	COG0439	Biotin carboxylase
A0R60_RS17455	COG0511	ligase activity, forming carbon-carbon bonds
A0R60_RS17460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A0R60_RS17465	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A0R60_RS17475	COG0604	alcohol dehydrogenase
A0R60_RS17480	COG2199	diguanylate cyclase activity
A0R60_RS17480	COG2200	EAL domain
A0R60_RS17485	COG1077	Cell shape determining protein MreB Mrl
A0R60_RS17495	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A0R60_RS17515	COG0312	modulator of DNA gyrase
A0R60_RS17520	COG0583	DNA-binding transcription factor activity
A0R60_RS17535	COG1289	transmembrane transporter activity
A0R60_RS17540	COG1012	belongs to the aldehyde dehydrogenase family
A0R60_RS17545	COG2732	(Barnase) inhibitor
A0R60_RS17560	COG1438	arginine binding
A0R60_RS17565	COG0039	L-malate dehydrogenase activity
A0R60_RS17570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A0R60_RS17575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A0R60_RS17580	COG3105	Protein conserved in bacteria
A0R60_RS17585	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A0R60_RS17595	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0R60_RS17605	COG0625	glutathione transferase activity
A0R60_RS17610	COG2969	positive regulation of protein catabolic process
A0R60_RS17615	COG2186	Transcriptional regulator
A0R60_RS17620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0R60_RS17630	COG1940	carbohydrate kinase activity
A0R60_RS17635	COG2731	YhcH YjgK YiaL family protein
A0R60_RS17640	COG0493	'glutamate synthase
A0R60_RS17645	COG0070	glutamate synthase
A0R60_RS17645	COG0069	glutamate synthase activity
A0R60_RS17645	COG0067	glutamate synthase
A0R60_RS17650	COG1242	4 iron, 4 sulfur cluster binding
A0R60_RS17665	COG0433	COG0433 Predicted ATPase
A0R60_RS17675	COG1064	alcohol dehydrogenase
A0R60_RS17690	COG2927	DNA polymerase III (CHI subunit)
A0R60_RS17695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A0R60_RS17705	COG0795	lipopolysaccharide-transporting ATPase activity
A0R60_RS17710	COG0795	lipopolysaccharide-transporting ATPase activity
A0R60_RS17715	COG5002	protein histidine kinase activity
A0R60_RS17715	COG0784	Response regulator, receiver
A0R60_RS17715	COG2198	Histidine kinase
A0R60_RS17720	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A0R60_RS17730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0R60_RS17750	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A0R60_RS17755	COG1137	ATPase activity
A0R60_RS17760	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A0R60_RS17765	COG3117	lipopolysaccharide transmembrane transporter activity
A0R60_RS17770	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A0R60_RS17780	COG0530	calcium, potassium:sodium antiporter activity
A0R60_RS17785	COG1127	ABC transporter
A0R60_RS17790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A0R60_RS17795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A0R60_RS17800	COG2854	intermembrane phospholipid transfer
A0R60_RS17805	COG3113	response to antibiotic
A0R60_RS17810	COG5007	Belongs to the BolA IbaG family
A0R60_RS17815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A0R60_RS17820	COG3423	Transcriptional regulator
A0R60_RS17825	COG0142	geranyltranstransferase activity
A0R60_RS17830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A0R60_RS17840	COG0697	spore germination
A0R60_RS17845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A0R60_RS17850	COG0642	Histidine kinase
A0R60_RS17855	COG0745	RESPONSE REGULATOR receiver
A0R60_RS17860	COG2027	D-alanyl-D-alanine carboxypeptidase
A0R60_RS17870	COG1534	Rna-binding protein
A0R60_RS17875	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A0R60_RS17885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A0R60_RS17890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A0R60_RS17895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A0R60_RS17905	COG0137	argininosuccinate synthase activity
A0R60_RS17930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A0R60_RS17935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A0R60_RS17940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A0R60_RS17945	COG1185	polyribonucleotide nucleotidyltransferase activity
A0R60_RS17960	COG0513	Belongs to the DEAD box helicase family
A0R60_RS17965	COG0814	amino acid
A0R60_RS17970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0R60_RS17975	COG0826	peptidase U32
A0R60_RS17980	COG0826	peptidase U32
A0R60_RS17985	COG3154	lipid carrier protein
A0R60_RS17990	COG3153	acetyltransferase
A0R60_RS17995	COG2827	Endonuclease containing a URI domain
A0R60_RS18000	COG3787	Belongs to the UPF0306 family
A0R60_RS18005	COG0693	protein deglycase activity
A0R60_RS18010	COG0702	epimerase
A0R60_RS18015	COG0701	Predicted permease
A0R60_RS18020	COG2823	Periplasmic or secreted lipoprotein
A0R60_RS18025	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A0R60_RS18030	COG0792	nuclease activity
A0R60_RS18035	COG3107	peptidoglycan biosynthetic process
A0R60_RS18055	COG0191	fructose-bisphosphate aldolase activity
A0R60_RS18060	COG2222	sugar isomerase
A0R60_RS18065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A0R60_RS18070	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0R60_RS18075	COG3716	PTS system mannose fructose sorbose family IID component
A0R60_RS18085	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0R60_RS18095	COG1349	DNA-binding transcription factor activity
A0R60_RS18100	COG2721	sulfolactate sulfo-lyase activity
A0R60_RS18110	COG2084	Dehydrogenase
A0R60_RS18120	COG0583	DNA-binding transcription factor activity
A0R60_RS18125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A0R60_RS18130	COG0814	amino acid
A0R60_RS18135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A0R60_RS18140	COG1882	Formate acetyltransferase
A0R60_RS18150	COG1741	Belongs to the pirin family
A0R60_RS18155	COG0583	DNA-binding transcription factor activity
A0R60_RS18160	COG3152	Membrane
A0R60_RS18170	COG2259	Doxx family
A0R60_RS18180	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
A0R60_RS18185	COG4575	ribosome binding
A0R60_RS18190	COG1422	Protein of unknown function (DUF1090)
A0R60_RS18200	COG0586	Pfam SNARE associated Golgi protein
A0R60_RS18205	COG2186	Transcriptional regulator
A0R60_RS18210	COG2271	Major facilitator Superfamily
A0R60_RS18220	COG2721	sulfolactate sulfo-lyase activity
A0R60_RS18230	COG0861	Integral membrane protein TerC family
A0R60_RS18235	COG0673	inositol 2-dehydrogenase activity
A0R60_RS18250	COG0446	pyridine nucleotide-disulphide oxidoreductase
A0R60_RS18250	COG1902	pentaerythritol trinitrate reductase activity
A0R60_RS18255	COG1070	Carbohydrate kinase
A0R60_RS18260	COG2390	Transcriptional regulator
A0R60_RS18265	COG1129	ABC transporter
A0R60_RS18270	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0R60_RS18275	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0R60_RS18285	COG1830	Aldolase
A0R60_RS18290	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A0R60_RS18295	COG4641	Protein conserved in bacteria
A0R60_RS18295	COG0438	transferase activity, transferring glycosyl groups
A0R60_RS18345	COG2235	arginine
A0R60_RS18370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A0R60_RS18375	COG0840	transmembrane signaling receptor activity
A0R60_RS18380	COG0840	transmembrane signaling receptor activity
A0R60_RS18385	COG1695	Transcriptional regulator
A0R60_RS18390	COG2375	cellular response to nickel ion
A0R60_RS18500	COG5301	cellulose 1,4-beta-cellobiosidase activity
A0R60_RS18580	COG3663	DNA glycosylase
A0R60_RS18595	COG0358	DNA primase activity
A0R60_RS18600	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A0R60_RS18610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A0R60_RS18615	COG0830	nickel cation binding
A0R60_RS18625	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A0R60_RS18630	COG0804	urea catabolic process
A0R60_RS18635	COG0832	Belongs to the urease beta subunit family
A0R60_RS18640	COG0831	urea catabolic process
A0R60_RS18645	COG0829	nickel cation binding
A0R60_RS18650	COG0657	acetylesterase activity
A0R60_RS18655	COG1846	Transcriptional regulator
A0R60_RS18670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A0R60_RS18680	COG0617	tRNA 3'-terminal CCA addition
A0R60_RS18685	COG4991	sh3 domain protein
A0R60_RS18690	COG3025	triphosphatase activity
A0R60_RS18700	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A0R60_RS18700	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A0R60_RS18720	COG3384	dioxygenase
A0R60_RS18725	COG0754	glutathionylspermidine amidase activity
A0R60_RS18740	COG0494	nUDIX hydrolase
A0R60_RS18745	COG3151	Protein conserved in bacteria
A0R60_RS18750	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A0R60_RS18755	COG3150	esterase
A0R60_RS18760	COG0187	DNA topoisomerase II activity
A0R60_RS18770	COG1120	ATPase activity
A0R60_RS18775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0R60_RS18780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0R60_RS18795	COG1652	LysM domain
A0R60_RS18800	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A0R60_RS18805	COG2249	NAD(P)H dehydrogenase (quinone) activity
A0R60_RS18820	COG3111	PFAM Bacterial OB fold (BOF) protein
A0R60_RS18840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A0R60_RS18845	COG1032	radical SAM domain protein
A0R60_RS18860	COG2207	Transcriptional regulator
A0R60_RS18865	COG0586	Pfam SNARE associated Golgi protein
A0R60_RS18880	COG0848	biopolymer transport protein
A0R60_RS18900	COG2862	Uncharacterized protein family, UPF0114
A0R60_RS18905	COG0667	Aldo Keto reductase
A0R60_RS18935	COG0625	glutathione transferase activity
A0R60_RS18945	COG0601	transmembrane transport
A0R60_RS18950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0R60_RS18955	COG0444	Belongs to the ABC transporter superfamily
A0R60_RS18975	COG1215	transferase activity, transferring glycosyl groups
A0R60_RS18985	COG0457	Tetratricopeptide repeat
A0R60_RS19055	COG0582	viral genome integration into host DNA
A0R60_RS19065	COG1811	Na channel or pump
A0R60_RS19070	COG1982	Orn Lys Arg decarboxylase major
A0R60_RS19085	COG3493	citrate carrier protein
A0R60_RS19100	COG3052	prosthetic group binding
A0R60_RS19125	COG2211	Major facilitator Superfamily
A0R60_RS19130	COG0741	lytic transglycosylase activity
A0R60_RS19140	COG1194	a g-specific adenine glycosylase
A0R60_RS19150	COG3171	Protein conserved in bacteria
A0R60_RS19160	COG2852	Protein conserved in bacteria
A0R60_RS19165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A0R60_RS19175	COG1872	DUF167
A0R60_RS19180	COG0762	integral membrane protein
A0R60_RS19185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A0R60_RS19190	COG2805	Type II/IV secretion system protein
A0R60_RS19195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A0R60_RS19210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A0R60_RS19215	COG2356	endonuclease I
A0R60_RS19220	COG3091	SprT-like family
A0R60_RS19245	COG1166	arginine decarboxylase activity
A0R60_RS19250	COG0010	Belongs to the arginase family
A0R60_RS19260	COG0501	Belongs to the peptidase M48B family
A0R60_RS19265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A0R60_RS19270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A0R60_RS19280	COG0191	fructose-bisphosphate aldolase activity
A0R60_RS19285	COG0668	transmembrane transport
A0R60_RS19290	COG1279	arginine transmembrane transporter activity
A0R60_RS19295	COG2968	Membrane
A0R60_RS19300	COG0583	DNA-binding transcription factor activity
A0R60_RS19305	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A0R60_RS19315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A0R60_RS19325	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A0R60_RS19340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0R60_RS19345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0R60_RS19350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A0R60_RS19360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A0R60_RS19360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A0R60_RS19365	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS19370	COG2723	6-phospho-beta-galactosidase activity
A0R60_RS19375	COG1737	Transcriptional regulator
A0R60_RS19385	COG1272	protein, Hemolysin III
A0R60_RS19390	COG0354	folic acid binding
A0R60_RS19395	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A0R60_RS19410	COG4974	Belongs to the 'phage' integrase family
A0R60_RS19430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A0R60_RS19435	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A0R60_RS19440	COG4942	peptidase
A0R60_RS19455	COG3842	ATPase activity
A0R60_RS19470	COG4565	transcriptional regulatory protein
A0R60_RS19480	COG3592	Divergent 4Fe-4S mono-cluster
A0R60_RS19485	COG2388	GCN5-related N-acetyl-transferase
A0R60_RS19500	COG0814	amino acid
A0R60_RS19515	COG0183	Belongs to the thiolase family
A0R60_RS19525	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS19535	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A0R60_RS19540	COG1794	racemase activity, acting on amino acids and derivatives
A0R60_RS19545	COG0583	DNA-binding transcription factor activity
A0R60_RS19555	COG1609	Transcriptional regulator
A0R60_RS19565	COG1609	Transcriptional regulator
A0R60_RS19585	COG0477	Major facilitator Superfamily
A0R60_RS19590	COG0667	Aldo Keto reductase
A0R60_RS19600	COG3066	DNA modification
A0R60_RS19605	COG0494	nUDIX hydrolase
A0R60_RS19615	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A0R60_RS19625	COG2165	general secretion pathway protein
A0R60_RS19630	COG4795	General secretion pathway protein
A0R60_RS19640	COG4967	type IV pilus modification protein PilV
A0R60_RS19660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A0R60_RS19665	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A0R60_RS19665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A0R60_RS19670	COG0860	N-Acetylmuramoyl-L-alanine amidase
A0R60_RS19690	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A0R60_RS19695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A0R60_RS19700	COG2166	iron-sulfur cluster assembly
A0R60_RS19705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A0R60_RS19715	COG0583	DNA-binding transcription factor activity
A0R60_RS19720	COG2363	Small membrane protein
A0R60_RS19725	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A0R60_RS19735	COG1760	l-serine dehydratase
A0R60_RS19740	COG0814	amino acid
A0R60_RS19745	COG1611	Belongs to the LOG family
A0R60_RS19765	COG3098	single-species biofilm formation
A0R60_RS19770	COG0564	pseudouridine synthase activity
A0R60_RS19775	COG0716	FMN binding
A0R60_RS19785	COG2271	Major facilitator Superfamily
A0R60_RS19790	COG4948	Mandelate Racemase Muconate Lactonizing
A0R60_RS19795	COG4948	Mandelate Racemase Muconate Lactonizing
A0R60_RS19805	COG4999	Histidine kinase
A0R60_RS19805	COG2205	protein histidine kinase activity
A0R60_RS19805	COG3437	response regulator, receiver
A0R60_RS19805	COG3850	Histidine kinase
A0R60_RS19810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A0R60_RS19815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A0R60_RS19820	COG3956	TIGRFAM MazG family protein
A0R60_RS19840	COG1737	Transcriptional regulator
A0R60_RS19845	COG1263	PTS System
A0R60_RS19845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0R60_RS19845	COG2190	(PTS) system
A0R60_RS19850	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A0R60_RS19855	COG0602	queuosine metabolic process
A0R60_RS19865	COG1473	amidohydrolase
A0R60_RS19875	COG0720	synthase
A0R60_RS19880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A0R60_RS19885	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A0R60_RS19895	COG2234	aminopeptidase activity
A0R60_RS19915	COG0529	Catalyzes the synthesis of activated sulfate
A0R60_RS19925	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A0R60_RS19930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A0R60_RS19955	COG1388	LysM domain
A0R60_RS19955	COG4942	peptidase
A0R60_RS19970	COG0477	Major facilitator Superfamily
A0R60_RS19985	COG0163	prenyltransferase activity
A0R60_RS19990	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A0R60_RS20020	COG1120	ATPase activity
A0R60_RS20025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0R60_RS20040	COG0309	Hydrogenase expression formation protein (HypE)
A0R60_RS20045	COG0409	Hydrogenase expression formation protein
A0R60_RS20050	COG0298	carbon dioxide binding
A0R60_RS20055	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A0R60_RS20060	COG0375	protein maturation
A0R60_RS20070	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A0R60_RS20075	COG0651	ATP synthesis coupled electron transport
A0R60_RS20085	COG3261	NADH dehydrogenase
A0R60_RS20085	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A0R60_RS20090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0R60_RS20095	COG3260	NADH ubiquinone oxidoreductase 20
A0R60_RS20105	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A0R60_RS20110	COG2723	6-phospho-beta-galactosidase activity
A0R60_RS20125	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A0R60_RS20130	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A0R60_RS20135	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A0R60_RS20140	COG0446	pyridine nucleotide-disulphide oxidoreductase
A0R60_RS20145	COG1773	rubredoxin
A0R60_RS20145	COG0426	domain, Protein
A0R60_RS20150	COG3604	Transcriptional regulator
A0R60_RS20160	COG1349	DNA-binding transcription factor activity
A0R60_RS20165	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0R60_RS20170	COG1028	Short-chain dehydrogenase reductase Sdr
A0R60_RS20185	COG3730	PTS system glucitol sorbitol-specific
A0R60_RS20190	COG2951	lytic endotransglycosylase activity
A0R60_RS20200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A0R60_RS20210	COG1546	Belongs to the CinA family
A0R60_RS20215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A0R60_RS20225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A0R60_RS20230	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A0R60_RS20260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0R60_RS20270	COG2918	glutathione biosynthetic process
A0R60_RS20285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A0R60_RS20290	COG2814	Major facilitator Superfamily
A0R60_RS20295	COG1566	PFAM secretion protein HlyD family protein
A0R60_RS20300	COG1846	Transcriptional regulator
A0R60_RS20305	COG2814	Major facilitator Superfamily
A0R60_RS20315	COG4176	ABC-type proline glycine betaine transport system permease component
A0R60_RS20320	COG4175	Glycine betaine
A0R60_RS20335	COG1780	Probably involved in ribonucleotide reductase function
A0R60_RS20370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A0R60_RS20375	COG0640	Transcriptional regulator
A0R60_RS20380	COG0401	homolog of Blt101
A0R60_RS20385	COG0583	DNA-binding transcription factor activity
A0R60_RS20390	COG0666	response to abiotic stimulus
A0R60_RS20395	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A0R60_RS20400	COG1304	FMN binding
A0R60_RS20410	COG0549	Belongs to the carbamate kinase family
A0R60_RS20415	COG0402	S-adenosylhomocysteine deaminase activity
A0R60_RS20430	COG0583	DNA-binding transcription factor activity
A0R60_RS20435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0R60_RS20455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0R60_RS20515	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A0R60_RS20580	COG3039	Transposase
A0R60_RS20585	COG0582	viral genome integration into host DNA
A0R60_RS20600	COG2867	negative regulation of translational initiation
A0R60_RS20620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A0R60_RS20625	COG4536	flavin adenine dinucleotide binding
A0R60_RS20630	COG4137	Cytochrome C assembly protein
A0R60_RS20635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A0R60_RS20645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A0R60_RS20675	COG2199	diguanylate cyclase activity
A0R60_RS20690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A0R60_RS20695	COG1605	Chorismate mutase
A0R60_RS20695	COG0287	Prephenate dehydrogenase
A0R60_RS20705	COG0077	Prephenate dehydratase
A0R60_RS20705	COG1605	Chorismate mutase
A0R60_RS20715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A0R60_RS20720	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A0R60_RS20735	COG0542	response to heat
A0R60_RS20760	COG0477	Major facilitator Superfamily
A0R60_RS20765	COG5544	Lipoprotein
A0R60_RS20770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A0R60_RS20780	COG3148	PFAM DTW domain containing protein
A0R60_RS20785	COG3118	belongs to the thioredoxin family
A0R60_RS20790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A0R60_RS20800	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A0R60_RS20805	COG0513	Belongs to the DEAD box helicase family
A0R60_RS20815	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A0R60_RS20830	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A0R60_RS20840	COG3086	response to oxidative stress
A0R60_RS20850	COG0681	Belongs to the peptidase S26 family
A0R60_RS20865	COG1381	Involved in DNA repair and RecF pathway recombination
A0R60_RS20870	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A0R60_RS20880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A0R60_RS20885	COG1737	Transcriptional regulator
A0R60_RS20900	COG0560	Phosphoserine phosphatase
A0R60_RS20910	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A0R60_RS20925	COG2205	protein histidine kinase activity
A0R60_RS20930	COG3170	Tfp pilus assembly protein FimV
A0R60_RS20935	COG2204	response regulator
A0R60_RS20940	COG0347	Belongs to the P(II) protein family
A0R60_RS20945	COG1017	nitric oxide dioxygenase activity
A0R60_RS20945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A0R60_RS20955	COG2259	Doxx family
A0R60_RS20965	COG2814	Major facilitator Superfamily
A0R60_RS20970	COG3711	transcriptional antiterminator
A0R60_RS20980	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A0R60_RS20995	COG1959	2 iron, 2 sulfur cluster binding
A0R60_RS21000	COG1104	cysteine desulfurase activity
A0R60_RS21005	COG0822	iron-sulfur transferase activity
A0R60_RS21010	COG0316	Belongs to the HesB IscA family
A0R60_RS21015	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A0R60_RS21020	COG0443	Heat shock 70 kDa protein
A0R60_RS21025	COG0633	Ferredoxin
A0R60_RS21030	COG2975	iron-sulfur cluster assembly
A0R60_RS21045	COG1737	Transcriptional regulator
A0R60_RS21060	COG1263	PTS System
A0R60_RS21060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0R60_RS21060	COG2190	(PTS) system
A0R60_RS21065	COG2373	Large extracellular alpha-helical protein
A0R60_RS21080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A0R60_RS21095	COG0124	histidyl-tRNA synthetase
A0R60_RS21110	COG1160	GTP binding
A0R60_RS21120	COG1645	bacterial-type flagellum-dependent swarming motility
A0R60_RS21135	COG1570	exodeoxyribonuclease VII activity
A0R60_RS21140	COG0517	IMP dehydrogenase activity
A0R60_RS21140	COG0516	GMP reductase activity
A0R60_RS21160	COG3962	Belongs to the TPP enzyme family
A0R60_RS21165	COG0673	inositol 2-dehydrogenase activity
A0R60_RS21180	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0R60_RS21185	COG0673	inositol 2-dehydrogenase activity
A0R60_RS21200	COG3718	enzyme involved in inositol metabolism
A0R60_RS21205	COG2814	Major facilitator Superfamily
A0R60_RS21230	COG0583	DNA-binding transcription factor activity
A0R60_RS21240	COG2200	EAL domain
A0R60_RS21255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A0R60_RS21270	COG2723	6-phospho-beta-galactosidase activity
A0R60_RS21275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A0R60_RS21280	COG2233	PERMEase
A0R60_RS21295	COG1446	asparaginase
A0R60_RS21310	COG1393	Belongs to the ArsC family
A0R60_RS21315	COG4783	chaperone-mediated protein folding
A0R60_RS21320	COG0628	permease
A0R60_RS21325	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A0R60_RS21330	COG2716	regulation of RNA biosynthetic process
A0R60_RS21340	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A0R60_RS21350	COG2321	neutral zinc metallopeptidase
A0R60_RS21360	COG0400	carboxylic ester hydrolase activity
A0R60_RS21375	COG1393	Belongs to the ArsC family
A0R60_RS21390	COG3850	Histidine kinase
A0R60_RS21395	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A0R60_RS21395	COG0493	'glutamate synthase
A0R60_RS21405	COG5342	invasion associated locus B
A0R60_RS21410	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A0R60_RS21425	COG0408	coproporphyrinogen oxidase activity
A0R60_RS21430	COG0860	N-Acetylmuramoyl-L-alanine amidase
A0R60_RS21455	COG4150	thiosulfate binding
A0R60_RS21460	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A0R60_RS21465	COG4208	sulfate ABC transporter
A0R60_RS21470	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A0R60_RS21495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0R60_RS21520	COG3115	cell septum assembly
A0R60_RS21525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A0R60_RS21530	COG3530	Putative quorum-sensing-regulated virulence factor
A0R60_RS21535	COG0385	Bile acid
A0R60_RS21540	COG0583	DNA-binding transcription factor activity
A0R60_RS21570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0R60_RS21575	COG3415	Transposase
A0R60_RS21580	COG3415	Transposase
A0R60_RS21605	COG1914	H( )-stimulated, divalent metal cation uptake system
A0R60_RS21615	COG0667	Aldo Keto reductase
A0R60_RS21620	COG3961	Belongs to the TPP enzyme family
A0R60_RS21635	COG3279	Response regulator of the LytR AlgR family
A0R60_RS21650	COG0436	Aminotransferase
A0R60_RS21660	COG1560	Kdo2-lipid A biosynthetic process
A0R60_RS21810	COG2067	long-chain fatty acid transport protein
A0R60_RS21815	COG3691	Protein conserved in bacteria
A0R60_RS21825	COG1024	Enoyl-CoA hydratase
A0R60_RS21825	COG1250	3-hydroxyacyl-CoA dehydrogenase
A0R60_RS21830	COG2062	phosphohistidine phosphatase, SixA
A0R60_RS21855	COG0730	response to heat
A0R60_RS21860	COG3101	peptidyl-lysine hydroxylation
A0R60_RS21870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0R60_RS21870	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A0R60_RS21875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0R60_RS21900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A0R60_RS21905	COG0101	tRNA pseudouridine synthase activity
A0R60_RS21910	COG0586	Pfam SNARE associated Golgi protein
A0R60_RS21920	COG0285	dihydrofolate synthase activity
A0R60_RS21925	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A0R60_RS21930	COG1286	toxin biosynthetic process
A0R60_RS21935	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A0R60_RS21940	COG0163	prenyltransferase activity
A0R60_RS21950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0R60_RS21960	COG4160	amino acid transport
A0R60_RS21965	COG4598	ABC transporter
A0R60_RS21975	COG1090	epimerase
A0R60_RS21980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A0R60_RS21985	COG0625	glutathione transferase activity
A0R60_RS21990	COG0625	glutathione transferase activity
A0R60_RS21995	COG0622	Phosphoesterase
A0R60_RS22005	COG1609	Transcriptional regulator
A0R60_RS22010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0R60_RS22020	COG3037	sugar-specific permease SgaT UlaA
A0R60_RS22030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A0R60_RS22055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0R60_RS22060	COG0471	metal ion transport
A0R60_RS22060	COG0490	domain, Protein
A0R60_RS22070	COG0436	Aminotransferase
A0R60_RS22080	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0R60_RS22110	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A0R60_RS22120	COG0839	Belongs to the complex I subunit 6 family
A0R60_RS22125	COG0713	ATP synthesis coupled electron transport
A0R60_RS22130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A0R60_RS22140	COG1007	ATP synthesis coupled electron transport
A0R60_RS22145	COG0835	chemotaxis
A0R60_RS22145	COG0784	Response regulator, receiver
A0R60_RS22155	COG2153	protein acetylation
A0R60_RS22160	COG4575	ribosome binding
A0R60_RS22165	COG1169	isochorismate synthase
A0R60_RS22170	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A0R60_RS22175	COG0596	Alpha beta hydrolase
A0R60_RS22185	COG1441	menaquinone biosynthetic process
A0R60_RS22205	COG0247	lactate metabolic process
A0R60_RS22210	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A0R60_RS22215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A0R60_RS22220	COG2271	Major facilitator Superfamily
A0R60_RS22225	COG2271	Major facilitator Superfamily
A0R60_RS22230	COG0584	glycerophosphoryl diester phosphodiesterase
A0R60_RS22235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A0R60_RS22250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A0R60_RS22260	COG0784	Response regulator, receiver
A0R60_RS22260	COG2205	protein histidine kinase activity
A0R60_RS22265	COG2197	response regulator
A0R60_RS22270	COG0642	Histidine kinase
A0R60_RS22270	COG2198	Histidine kinase
A0R60_RS22285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A0R60_RS22285	COG2169	Transcriptional regulator
A0R60_RS22290	COG3145	DNA-N1-methyladenine dioxygenase activity
A0R60_RS22295	COG4615	Cyclic peptide transporter
A0R60_RS22300	COG2239	Acts as a magnesium transporter
A0R60_RS22305	COG0659	secondary active sulfate transmembrane transporter activity
A0R60_RS22320	COG3182	Iron-regulated membrane protein
A0R60_RS22340	COG3082	Protein of unknown function (DUF1414)
A0R60_RS22345	COG3081	Nucleoid-associated protein
A0R60_RS22355	COG1061	Type III restriction enzyme res subunit
A0R60_RS22360	COG1187	pseudouridine synthase activity
A0R60_RS22365	COG2814	Major facilitator Superfamily
A0R60_RS22375	COG4172	Belongs to the ABC transporter superfamily
A0R60_RS22380	COG4239	(ABC) transporter, permease
A0R60_RS22385	COG4174	ABC transporter (Permease)
A0R60_RS22390	COG4166	transmembrane transport
A0R60_RS22395	COG2200	EAL domain
A0R60_RS22400	COG0791	NLP P60 protein
A0R60_RS22405	COG0671	phosphoesterase, PA-phosphatase related
A0R60_RS22420	COG1312	Catalyzes the dehydration of D-mannonate
A0R60_RS22425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A0R60_RS22440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0R60_RS22440	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0R60_RS22445	COG1105	Belongs to the carbohydrate kinase PfkB family
A0R60_RS22450	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A0R60_RS22450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0R60_RS22450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A0R60_RS22455	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A0R60_RS22460	COG2855	membrane
A0R60_RS22465	COG0583	DNA-binding transcription factor activity
A0R60_RS22470	COG0833	amino acid
A0R60_RS22480	COG4771	TonB-dependent receptor
A0R60_RS22490	COG0477	Major facilitator Superfamily
A0R60_RS22500	COG2311	Membrane
A0R60_RS22515	COG1129	ABC transporter