locus-tag	class	description
HCU35_RS00010	COG0592	DNA-directed DNA polymerase activity
HCU35_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCU35_RS00025	COG0583	DNA-binding transcription factor activity
HCU35_RS00030	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS00030	COG3321	synthase
HCU35_RS00030	COG0604	alcohol dehydrogenase
HCU35_RS00035	COG0561	phosphatase activity
HCU35_RS00040	COG2186	Transcriptional regulator
HCU35_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
HCU35_RS00050	COG0800	Aldolase
HCU35_RS00055	COG4948	Mandelate Racemase Muconate Lactonizing
HCU35_RS00060	COG2271	Major facilitator Superfamily
HCU35_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
HCU35_RS00070	COG5645	(Lipo)protein
HCU35_RS00080	COG0071	Belongs to the small heat shock protein (HSP20) family
HCU35_RS00085	COG2985	domain, Protein
HCU35_RS00090	COG2188	Transcriptional regulator
HCU35_RS00105	COG2149	membrane
HCU35_RS00120	COG2610	gluconate transmembrane transporter activity
HCU35_RS00125	COG0583	DNA-binding transcription factor activity
HCU35_RS00135	COG2814	Major facilitator Superfamily
HCU35_RS00170	COG0028	Belongs to the TPP enzyme family
HCU35_RS00175	COG0440	acetolactate synthase activity
HCU35_RS00180	COG2197	response regulator
HCU35_RS00200	COG0596	Alpha beta hydrolase
HCU35_RS00205	COG0583	DNA-binding transcription factor activity
HCU35_RS00225	COG0697	spore germination
HCU35_RS00230	COG4580	involved in the transport of maltose and maltodextrins
HCU35_RS00235	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCU35_RS00240	COG2723	6-phospho-beta-galactosidase activity
HCU35_RS00245	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU35_RS00245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU35_RS00255	COG1609	Transcriptional regulator
HCU35_RS00265	COG2814	Major facilitator Superfamily
HCU35_RS00275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCU35_RS00280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCU35_RS00290	COG0454	-acetyltransferase
HCU35_RS00295	COG1309	transcriptional regulator
HCU35_RS00305	COG1464	Belongs to the NlpA lipoprotein family
HCU35_RS00330	COG3188	usher protein
HCU35_RS00335	COG3121	Chaperone
HCU35_RS00365	COG3188	usher protein
HCU35_RS00390	COG2274	protein secretion by the type I secretion system
HCU35_RS00405	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HCU35_RS00420	COG3272	Protein of unknown function (DUF1722)
HCU35_RS00425	COG2351	hydroxyisourate hydrolase activity
HCU35_RS00455	COG3121	Chaperone
HCU35_RS00485	COG0519	Catalyzes the synthesis of GMP from XMP
HCU35_RS00540	COG2003	Belongs to the UPF0758 family
HCU35_RS00575	COG0659	secondary active sulfate transmembrane transporter activity
HCU35_RS00580	COG0589	response to stress
HCU35_RS00595	COG0431	NADPH-dependent FMN reductase
HCU35_RS00625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCU35_RS00650	COG0210	DNA helicase
HCU35_RS00655	COG0582	viral genome integration into host DNA
HCU35_RS00665	COG2211	Major facilitator Superfamily
HCU35_RS00670	COG1501	Belongs to the glycosyl hydrolase 31 family
HCU35_RS00675	COG2982	Protein involved in outer membrane biogenesis
HCU35_RS00680	COG2233	PERMEase
HCU35_RS00685	COG0786	glutamate:sodium symporter activity
HCU35_RS00690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCU35_RS00695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCU35_RS00700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCU35_RS00715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCU35_RS00735	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCU35_RS00740	COG1596	polysaccharide export
HCU35_RS00745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCU35_RS00750	COG3206	protein involved in exopolysaccharide biosynthesis
HCU35_RS00750	COG0489	protein tyrosine kinase activity
HCU35_RS00755	COG2860	membrane
HCU35_RS00760	COG1561	YicC-like family, N-terminal region
HCU35_RS00770	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCU35_RS00780	COG0756	dUTP diphosphatase activity
HCU35_RS00785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCU35_RS00790	COG2003	Belongs to the UPF0758 family
HCU35_RS00795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HCU35_RS00800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HCU35_RS00805	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCU35_RS00810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HCU35_RS00820	COG1519	Transferase
HCU35_RS00825	COG1216	Glycosyl transferase, family 2
HCU35_RS00830	COG0438	transferase activity, transferring glycosyl groups
HCU35_RS00840	COG0859	PFAM glycosyl transferase family 9
HCU35_RS00860	COG0859	PFAM glycosyl transferase family 9
HCU35_RS00865	COG0859	PFAM glycosyl transferase family 9
HCU35_RS00880	COG1063	alcohol dehydrogenase
HCU35_RS00890	COG0438	transferase activity, transferring glycosyl groups
HCU35_RS00895	COG0463	Glycosyl transferase, family 2
HCU35_RS00900	COG2861	carbohydrate metabolic process
HCU35_RS00905	COG4942	peptidase
HCU35_RS00910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HCU35_RS00915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCU35_RS00920	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCU35_RS00925	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HCU35_RS00930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HCU35_RS00940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCU35_RS00950	COG0248	Ppx GppA phosphatase
HCU35_RS00960	COG3118	belongs to the thioredoxin family
HCU35_RS00965	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HCU35_RS00970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCU35_RS00980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCU35_RS00985	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HCU35_RS00990	COG0456	acetyltransferase
HCU35_RS00995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCU35_RS01000	COG2244	polysaccharide biosynthetic process
HCU35_RS01015	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HCU35_RS01045	COG3071	HemY protein
HCU35_RS01050	COG2959	enzyme of heme biosynthesis
HCU35_RS01060	COG0181	hydroxymethylbilane synthase activity
HCU35_RS01075	COG5567	small periplasmic lipoprotein
HCU35_RS01095	COG1011	Hydrolase
HCU35_RS01100	COG0210	DNA helicase
HCU35_RS01110	COG2962	Rard protein
HCU35_RS01120	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HCU35_RS01130	COG1280	lysine exporter protein (LysE YggA)
HCU35_RS01135	COG1280	lysine exporter protein (LysE YggA)
HCU35_RS01140	COG2267	carboxylic ester hydrolase activity
HCU35_RS01145	COG0561	phosphatase activity
HCU35_RS01150	COG0697	spore germination
HCU35_RS01155	COG0583	DNA-binding transcription factor activity
HCU35_RS01165	COG0412	Dienelactone hydrolase
HCU35_RS01175	COG1322	Protein conserved in bacteria
HCU35_RS01180	COG2226	methyltransferase
HCU35_RS01185	COG3165	ubiquinone biosynthetic process from chorismate
HCU35_RS01190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HCU35_RS01205	COG0805	protein transport
HCU35_RS01210	COG0084	hydrolase, TatD family'
HCU35_RS01220	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCU35_RS01230	COG0488	(ABC) transporter
HCU35_RS01235	COG2944	sequence-specific DNA binding
HCU35_RS01245	COG1278	Cold shock
HCU35_RS01250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCU35_RS01260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCU35_RS01270	COG1609	Transcriptional regulator
HCU35_RS01275	COG2885	chlorophyll binding
HCU35_RS01280	COG0243	molybdopterin cofactor binding
HCU35_RS01285	COG0456	acetyltransferase
HCU35_RS01290	COG2818	Glycosylase
HCU35_RS01295	COG5571	outer membrane autotransporter
HCU35_RS01300	COG2223	nitrite transmembrane transporter activity
HCU35_RS01315	COG0747	negative chemotaxis
HCU35_RS01320	COG0601	transmembrane transport
HCU35_RS01325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCU35_RS01330	COG0444	Belongs to the ABC transporter superfamily
HCU35_RS01335	COG4608	Belongs to the ABC transporter superfamily
HCU35_RS01340	COG1072	(Pantothenic acid kinase))
HCU35_RS01375	COG0250	Participates in transcription elongation, termination and antitermination
HCU35_RS01420	COG3706	GGDEF domain
HCU35_RS01430	COG2022	thiamine diphosphate biosynthetic process
HCU35_RS01435	COG2104	thiamine diphosphate biosynthetic process
HCU35_RS01440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCU35_RS01455	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HCU35_RS01465	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HCU35_RS01470	COG1515	deoxyribonuclease V activity
HCU35_RS01475	COG3068	Protein conserved in bacteria
HCU35_RS01490	COG0151	Belongs to the GarS family
HCU35_RS01520	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HCU35_RS01530	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HCU35_RS01560	COG1187	pseudouridine synthase activity
HCU35_RS01575	COG0527	aspartate kinase activity
HCU35_RS01600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCU35_RS01605	COG3223	Belongs to the PsiE family
HCU35_RS01630	COG4580	involved in the transport of maltose and maltodextrins
HCU35_RS01640	COG3161	chorismate lyase activity
HCU35_RS01650	COG2937	Belongs to the GPAT DAPAT family
HCU35_RS01655	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HCU35_RS01660	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HCU35_RS01665	COG0534	Mate efflux family protein
HCU35_RS01670	COG3237	CsbD-like
HCU35_RS01675	COG0735	belongs to the Fur family
HCU35_RS01690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCU35_RS01700	COG0604	alcohol dehydrogenase
HCU35_RS01705	COG0305	Participates in initiation and elongation during chromosome replication
HCU35_RS01715	COG1448	Aminotransferase
HCU35_RS01720	COG3700	Belongs to the class B bacterial acid phosphatase family
HCU35_RS01730	COG2315	Protein conserved in bacteria
HCU35_RS01740	COG0629	single-stranded DNA binding
HCU35_RS01750	COG2199	diguanylate cyclase activity
HCU35_RS01755	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HCU35_RS01765	COG0789	Transcriptional regulator
HCU35_RS01770	COG0625	glutathione transferase activity
HCU35_RS01775	COG2252	PERMEase
HCU35_RS01780	COG0025	NhaP-type Na H and K H
HCU35_RS01785	COG0583	DNA-binding transcription factor activity
HCU35_RS01795	COG1346	cytolysis
HCU35_RS01800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCU35_RS01805	COG3162	membrane
HCU35_RS01815	COG1301	dicarboxylic acid transport
HCU35_RS01820	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HCU35_RS01845	COG0191	fructose-bisphosphate aldolase activity
HCU35_RS01860	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCU35_RS01865	COG1129	ABC transporter
HCU35_RS01870	COG4191	Histidine kinase
HCU35_RS01870	COG0784	Response regulator, receiver
HCU35_RS01875	COG1940	carbohydrate kinase activity
HCU35_RS01880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCU35_RS01885	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCU35_RS01890	COG1129	ABC transporter
HCU35_RS01895	COG1879	ABC-type sugar transport system periplasmic component
HCU35_RS01900	COG1737	Transcriptional regulator
HCU35_RS01905	COG0698	ribose 5-phosphate isomerase
HCU35_RS01915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HCU35_RS01920	COG0456	acetyltransferase
HCU35_RS01925	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HCU35_RS01930	COG3454	Phosphonate metabolism
HCU35_RS01935	COG4778	phosphonate C-P lyase system protein PhnL
HCU35_RS01940	COG4107	phosphonate C-P lyase system protein PhnK
HCU35_RS01945	COG3627	carbon phosphorus lyase activity
HCU35_RS01950	COG3626	phosphonate metabolism
HCU35_RS01955	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HCU35_RS01960	COG3624	Phosphonate C-P lyase system protein PhnG
HCU35_RS01965	COG2188	Transcriptional regulator
HCU35_RS01970	COG3639	organic phosphonate transmembrane transporter activity
HCU35_RS01975	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HCU35_RS01985	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HCU35_RS01990	COG2824	Alkylphosphonate utilization operon protein PhnA
HCU35_RS01995	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCU35_RS02015	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HCU35_RS02055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCU35_RS02060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCU35_RS02065	COG1309	transcriptional regulator
HCU35_RS02100	COG4145	pantothenate transmembrane transporter activity
HCU35_RS02105	COG3924	membrane
HCU35_RS02110	COG0439	Biotin carboxylase
HCU35_RS02115	COG0511	ligase activity, forming carbon-carbon bonds
HCU35_RS02120	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HCU35_RS02125	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HCU35_RS02135	COG0604	alcohol dehydrogenase
HCU35_RS02140	COG2200	EAL domain
HCU35_RS02140	COG2199	diguanylate cyclase activity
HCU35_RS02145	COG1077	Cell shape determining protein MreB Mrl
HCU35_RS02150	COG1792	Involved in formation and maintenance of cell shape
HCU35_RS02155	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HCU35_RS02170	COG3164	Protein of unknown function
HCU35_RS02175	COG0312	modulator of DNA gyrase
HCU35_RS02180	COG3477	response to acidic pH
HCU35_RS02185	COG0583	DNA-binding transcription factor activity
HCU35_RS02200	COG1289	transmembrane transporter activity
HCU35_RS02205	COG1012	belongs to the aldehyde dehydrogenase family
HCU35_RS02210	COG2732	(Barnase) inhibitor
HCU35_RS02220	COG1438	arginine binding
HCU35_RS02230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCU35_RS02235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCU35_RS02240	COG3105	Protein conserved in bacteria
HCU35_RS02245	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HCU35_RS02255	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HCU35_RS02260	COG0625	glutathione transferase activity
HCU35_RS02265	COG2969	positive regulation of protein catabolic process
HCU35_RS02270	COG2186	Transcriptional regulator
HCU35_RS02275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCU35_RS02290	COG2731	YhcH YjgK YiaL family protein
HCU35_RS02295	COG0402	S-adenosylhomocysteine deaminase activity
HCU35_RS02300	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HCU35_RS02305	COG0493	'glutamate synthase
HCU35_RS02310	COG0067	glutamate synthase
HCU35_RS02310	COG0069	glutamate synthase activity
HCU35_RS02310	COG0070	glutamate synthase
HCU35_RS02315	COG1242	4 iron, 4 sulfur cluster binding
HCU35_RS02320	COG0433	COG0433 Predicted ATPase
HCU35_RS02330	COG1064	alcohol dehydrogenase
HCU35_RS02335	COG0456	acetyltransferase
HCU35_RS02345	COG2927	DNA polymerase III (CHI subunit)
HCU35_RS02350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HCU35_RS02355	COG0795	lipopolysaccharide-transporting ATPase activity
HCU35_RS02360	COG0795	lipopolysaccharide-transporting ATPase activity
HCU35_RS02365	COG2198	Histidine kinase
HCU35_RS02365	COG0784	Response regulator, receiver
HCU35_RS02365	COG5002	protein histidine kinase activity
HCU35_RS02370	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HCU35_RS02380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS02400	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HCU35_RS02405	COG1137	ATPase activity
HCU35_RS02410	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HCU35_RS02415	COG3117	lipopolysaccharide transmembrane transporter activity
HCU35_RS02420	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HCU35_RS02430	COG0530	calcium, potassium:sodium antiporter activity
HCU35_RS02435	COG1127	ABC transporter
HCU35_RS02440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HCU35_RS02445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HCU35_RS02450	COG2854	intermembrane phospholipid transfer
HCU35_RS02455	COG3113	response to antibiotic
HCU35_RS02460	COG5007	Belongs to the BolA IbaG family
HCU35_RS02465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCU35_RS02470	COG3423	Transcriptional regulator
HCU35_RS02475	COG0142	geranyltranstransferase activity
HCU35_RS02480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCU35_RS02490	COG0697	spore germination
HCU35_RS02495	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCU35_RS02500	COG0642	Histidine kinase
HCU35_RS02505	COG0745	RESPONSE REGULATOR receiver
HCU35_RS02510	COG2027	D-alanyl-D-alanine carboxypeptidase
HCU35_RS02520	COG1534	Rna-binding protein
HCU35_RS02525	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HCU35_RS02535	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCU35_RS02540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCU35_RS02545	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCU35_RS02555	COG0137	argininosuccinate synthase activity
HCU35_RS02575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCU35_RS02580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HCU35_RS02585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HCU35_RS02590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HCU35_RS02610	COG0513	Belongs to the DEAD box helicase family
HCU35_RS02615	COG0814	amino acid
HCU35_RS02620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCU35_RS02625	COG0826	peptidase U32
HCU35_RS02630	COG0826	peptidase U32
HCU35_RS02635	COG3154	lipid carrier protein
HCU35_RS02640	COG3153	acetyltransferase
HCU35_RS02645	COG2827	Endonuclease containing a URI domain
HCU35_RS02650	COG3787	Belongs to the UPF0306 family
HCU35_RS02655	COG0693	protein deglycase activity
HCU35_RS02660	COG0702	epimerase
HCU35_RS02665	COG0701	Predicted permease
HCU35_RS02670	COG2823	Periplasmic or secreted lipoprotein
HCU35_RS02675	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HCU35_RS02680	COG0792	nuclease activity
HCU35_RS02685	COG3107	peptidoglycan biosynthetic process
HCU35_RS02690	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCU35_RS02705	COG1263	PTS System
HCU35_RS02705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU35_RS02710	COG0191	fructose-bisphosphate aldolase activity
HCU35_RS02715	COG2222	sugar isomerase
HCU35_RS02720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HCU35_RS02725	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS02730	COG3716	PTS system mannose fructose sorbose family IID component
HCU35_RS02740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU35_RS02750	COG1349	DNA-binding transcription factor activity
HCU35_RS02755	COG2721	sulfolactate sulfo-lyase activity
HCU35_RS02765	COG2084	Dehydrogenase
HCU35_RS02770	COG1929	Belongs to the glycerate kinase type-1 family
HCU35_RS02780	COG0583	DNA-binding transcription factor activity
HCU35_RS02785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCU35_RS02790	COG0814	amino acid
HCU35_RS02795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HCU35_RS02800	COG1882	Formate acetyltransferase
HCU35_RS02805	COG0814	amino acid
HCU35_RS02815	COG1741	Belongs to the pirin family
HCU35_RS02820	COG0583	DNA-binding transcription factor activity
HCU35_RS02825	COG3152	Membrane
HCU35_RS02830	COG0435	Glutathione S-transferase
HCU35_RS02835	COG2259	Doxx family
HCU35_RS02845	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HCU35_RS02850	COG4575	ribosome binding
HCU35_RS02855	COG1422	Protein of unknown function (DUF1090)
HCU35_RS02865	COG0586	Pfam SNARE associated Golgi protein
HCU35_RS02870	COG2186	Transcriptional regulator
HCU35_RS02875	COG2271	Major facilitator Superfamily
HCU35_RS02885	COG2721	sulfolactate sulfo-lyase activity
HCU35_RS02895	COG0861	Integral membrane protein TerC family
HCU35_RS02900	COG0673	inositol 2-dehydrogenase activity
HCU35_RS02905	COG1451	nucleotide metabolic process
HCU35_RS02915	COG0446	pyridine nucleotide-disulphide oxidoreductase
HCU35_RS02915	COG1902	pentaerythritol trinitrate reductase activity
HCU35_RS02920	COG1070	Carbohydrate kinase
HCU35_RS02925	COG2390	Transcriptional regulator
HCU35_RS02930	COG1129	ABC transporter
HCU35_RS02935	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCU35_RS02940	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCU35_RS02945	COG1879	ABC-type sugar transport system periplasmic component
HCU35_RS02950	COG1830	Aldolase
HCU35_RS02955	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HCU35_RS02970	COG3121	Chaperone
HCU35_RS02980	COG3539	Fimbrial protein
HCU35_RS02990	COG3188	usher protein
HCU35_RS02995	COG3121	Chaperone
HCU35_RS03010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCU35_RS03015	COG0840	transmembrane signaling receptor activity
HCU35_RS03020	COG0840	transmembrane signaling receptor activity
HCU35_RS03025	COG1695	Transcriptional regulator
HCU35_RS03030	COG2375	cellular response to nickel ion
HCU35_RS03045	COG3663	DNA glycosylase
HCU35_RS03055	COG0358	DNA primase activity
HCU35_RS03060	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCU35_RS03070	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HCU35_RS03075	COG0830	nickel cation binding
HCU35_RS03085	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HCU35_RS03090	COG0804	urea catabolic process
HCU35_RS03095	COG0832	Belongs to the urease beta subunit family
HCU35_RS03100	COG0831	urea catabolic process
HCU35_RS03105	COG0829	nickel cation binding
HCU35_RS03110	COG0477	Major facilitator Superfamily
HCU35_RS03120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCU35_RS03130	COG0617	tRNA 3'-terminal CCA addition
HCU35_RS03135	COG4991	sh3 domain protein
HCU35_RS03140	COG3025	triphosphatase activity
HCU35_RS03150	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HCU35_RS03150	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HCU35_RS03160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCU35_RS03165	COG3539	Fimbrial protein
HCU35_RS03170	COG3121	Chaperone
HCU35_RS03175	COG3188	usher protein
HCU35_RS03180	COG3539	Fimbrial protein
HCU35_RS03190	COG3384	dioxygenase
HCU35_RS03195	COG0754	glutathionylspermidine amidase activity
HCU35_RS03210	COG0494	nUDIX hydrolase
HCU35_RS03215	COG3151	Protein conserved in bacteria
HCU35_RS03220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCU35_RS03225	COG3150	esterase
HCU35_RS03230	COG0187	DNA topoisomerase II activity
HCU35_RS03235	COG4774	siderophore transport
HCU35_RS03240	COG1120	ATPase activity
HCU35_RS03245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU35_RS03250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU35_RS03275	COG2211	Major facilitator Superfamily
HCU35_RS03280	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HCU35_RS03285	COG1652	LysM domain
HCU35_RS03290	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HCU35_RS03295	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCU35_RS03310	COG3111	PFAM Bacterial OB fold (BOF) protein
HCU35_RS03365	COG0640	Transcriptional regulator
HCU35_RS03370	COG1902	pentaerythritol trinitrate reductase activity
HCU35_RS03380	COG1234	tRNA 3'-trailer cleavage
HCU35_RS03385	COG0697	spore germination
HCU35_RS03455	COG0604	alcohol dehydrogenase
HCU35_RS03490	COG1979	alcohol dehydrogenase
HCU35_RS03495	COG2207	Transcriptional regulator
HCU35_RS03500	COG0586	Pfam SNARE associated Golgi protein
HCU35_RS03505	COG0626	cystathionine gamma-synthase activity
HCU35_RS03515	COG0848	biopolymer transport protein
HCU35_RS03535	COG2862	Uncharacterized protein family, UPF0114
HCU35_RS03540	COG0667	Aldo Keto reductase
HCU35_RS03545	COG0840	transmembrane signaling receptor activity
HCU35_RS03550	COG1349	DNA-binding transcription factor activity
HCU35_RS03555	COG0625	glutathione transferase activity
HCU35_RS03560	COG0754	glutathionylspermidine amidase activity
HCU35_RS03575	COG1649	PFAM Uncharacterised BCR, COG1649
HCU35_RS03575	COG0726	polysaccharide deacetylase
HCU35_RS03580	COG0457	Tetratricopeptide repeat
HCU35_RS03600	COG2197	response regulator
HCU35_RS03605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCU35_RS03605	COG2205	protein histidine kinase activity
HCU35_RS03615	COG1811	Na channel or pump
HCU35_RS03620	COG1982	Orn Lys Arg decarboxylase major
HCU35_RS03635	COG3493	citrate carrier protein
HCU35_RS03640	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCU35_RS03650	COG3052	prosthetic group binding
HCU35_RS03670	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HCU35_RS03675	COG2211	Major facilitator Superfamily
HCU35_RS03680	COG0741	lytic transglycosylase activity
HCU35_RS03690	COG1194	a g-specific adenine glycosylase
HCU35_RS03700	COG3171	Protein conserved in bacteria
HCU35_RS03710	COG2852	Protein conserved in bacteria
HCU35_RS03715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCU35_RS03725	COG1872	DUF167
HCU35_RS03730	COG0762	integral membrane protein
HCU35_RS03735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HCU35_RS03740	COG2805	Type II/IV secretion system protein
HCU35_RS03760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HCU35_RS03765	COG2356	endonuclease I
HCU35_RS03770	COG3091	SprT-like family
HCU35_RS03775	COG2814	Major facilitator Superfamily
HCU35_RS03795	COG1166	arginine decarboxylase activity
HCU35_RS03800	COG0010	Belongs to the arginase family
HCU35_RS03810	COG2146	nitrite reductase [NAD(P)H] activity
HCU35_RS03825	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS03830	COG1414	Transcriptional regulator
HCU35_RS03855	COG2267	carboxylic ester hydrolase activity
HCU35_RS03860	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS03865	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HCU35_RS03885	COG0501	Belongs to the peptidase M48B family
HCU35_RS03890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCU35_RS03895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCU35_RS03900	COG0126	phosphoglycerate kinase activity
HCU35_RS03905	COG0191	fructose-bisphosphate aldolase activity
HCU35_RS03910	COG0668	transmembrane transport
HCU35_RS03915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HCU35_RS03920	COG1279	arginine transmembrane transporter activity
HCU35_RS03925	COG2968	Membrane
HCU35_RS03930	COG0583	DNA-binding transcription factor activity
HCU35_RS03935	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HCU35_RS03940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCU35_RS03945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCU35_RS03955	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HCU35_RS03965	COG0006	proline dipeptidase activity
HCU35_RS03970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCU35_RS03975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCU35_RS03980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCU35_RS03990	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCU35_RS03990	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCU35_RS03995	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS04000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCU35_RS04020	COG2723	6-phospho-beta-galactosidase activity
HCU35_RS04025	COG1737	Transcriptional regulator
HCU35_RS04030	COG1272	protein, Hemolysin III
HCU35_RS04035	COG0354	folic acid binding
HCU35_RS04040	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HCU35_RS04055	COG4974	Belongs to the 'phage' integrase family
HCU35_RS04065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCU35_RS04075	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCU35_RS04080	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HCU35_RS04085	COG4942	peptidase
HCU35_RS04105	COG1335	isochorismatase
HCU35_RS04110	COG2067	long-chain fatty acid transport protein
HCU35_RS04130	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HCU35_RS04135	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS04140	COG3111	PFAM Bacterial OB fold (BOF) protein
HCU35_RS04155	COG1546	Belongs to the CinA family
HCU35_RS04170	COG1294	oxidase, subunit
HCU35_RS04175	COG1271	oxidase subunit
HCU35_RS04180	COG3546	catalase activity
HCU35_RS04185	COG3685	Protein conserved in bacteria
HCU35_RS04190	COG3685	Protein conserved in bacteria
HCU35_RS04195	COG3729	General stress protein
HCU35_RS04200	COG3592	Divergent 4Fe-4S mono-cluster
HCU35_RS04205	COG2388	GCN5-related N-acetyl-transferase
HCU35_RS04210	COG0814	amino acid
HCU35_RS04225	COG0183	Belongs to the thiolase family
HCU35_RS04230	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HCU35_RS04235	COG0823	Involved in the tonB-independent uptake of proteins
HCU35_RS04240	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HCU35_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS04250	COG2814	Major facilitator Superfamily
HCU35_RS04260	COG3842	ATPase activity
HCU35_RS04265	COG0395	ABC-type sugar transport system, permease component
HCU35_RS04270	COG1175	transmembrane transport
HCU35_RS04275	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HCU35_RS04285	COG1794	racemase activity, acting on amino acids and derivatives
HCU35_RS04290	COG0583	DNA-binding transcription factor activity
HCU35_RS04300	COG1609	Transcriptional regulator
HCU35_RS04305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU35_RS04310	COG2723	6-phospho-beta-galactosidase activity
HCU35_RS04315	COG2186	Transcriptional regulator
HCU35_RS04325	COG1609	Transcriptional regulator
HCU35_RS04330	COG0204	Acyl-transferase
HCU35_RS04330	COG0318	PFAM AMP-dependent synthetase and ligase
HCU35_RS04335	COG0477	Major facilitator Superfamily
HCU35_RS04340	COG0667	Aldo Keto reductase
HCU35_RS04350	COG3066	DNA modification
HCU35_RS04355	COG0494	nUDIX hydrolase
HCU35_RS04365	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HCU35_RS04370	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HCU35_RS04375	COG2165	general secretion pathway protein
HCU35_RS04380	COG4795	General secretion pathway protein
HCU35_RS04390	COG4967	type IV pilus modification protein PilV
HCU35_RS04395	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HCU35_RS04405	COG1074	ATP-dependent DNA helicase activity
HCU35_RS04410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCU35_RS04415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HCU35_RS04415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HCU35_RS04420	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCU35_RS04440	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HCU35_RS04445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HCU35_RS04450	COG2166	iron-sulfur cluster assembly
HCU35_RS04455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCU35_RS04465	COG0583	DNA-binding transcription factor activity
HCU35_RS04470	COG2363	Small membrane protein
HCU35_RS04475	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HCU35_RS04485	COG1760	l-serine dehydratase
HCU35_RS04490	COG0814	amino acid
HCU35_RS04495	COG1611	Belongs to the LOG family
HCU35_RS04510	COG3098	single-species biofilm formation
HCU35_RS04515	COG0564	pseudouridine synthase activity
HCU35_RS04520	COG0716	FMN binding
HCU35_RS04525	COG2271	Major facilitator Superfamily
HCU35_RS04530	COG4948	Mandelate Racemase Muconate Lactonizing
HCU35_RS04535	COG4948	Mandelate Racemase Muconate Lactonizing
HCU35_RS04540	COG1929	Belongs to the glycerate kinase type-1 family
HCU35_RS04545	COG2205	protein histidine kinase activity
HCU35_RS04545	COG4999	Histidine kinase
HCU35_RS04545	COG3850	Histidine kinase
HCU35_RS04545	COG3437	response regulator, receiver
HCU35_RS04550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCU35_RS04555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCU35_RS04560	COG3956	TIGRFAM MazG family protein
HCU35_RS04575	COG1737	Transcriptional regulator
HCU35_RS04580	COG1263	PTS System
HCU35_RS04580	COG2190	(PTS) system
HCU35_RS04580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU35_RS04585	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HCU35_RS04590	COG0602	queuosine metabolic process
HCU35_RS04600	COG1473	amidohydrolase
HCU35_RS04610	COG0720	synthase
HCU35_RS04615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCU35_RS04630	COG2234	aminopeptidase activity
HCU35_RS04650	COG0529	Catalyzes the synthesis of activated sulfate
HCU35_RS04660	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HCU35_RS04665	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HCU35_RS04675	COG0585	pseudouridine synthase activity
HCU35_RS04690	COG4942	peptidase
HCU35_RS04690	COG1388	LysM domain
HCU35_RS04705	COG0477	Major facilitator Superfamily
HCU35_RS04720	COG0163	prenyltransferase activity
HCU35_RS04725	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCU35_RS04735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HCU35_RS04755	COG0309	Hydrogenase expression formation protein (HypE)
HCU35_RS04760	COG0409	Hydrogenase expression formation protein
HCU35_RS04765	COG0298	carbon dioxide binding
HCU35_RS04770	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HCU35_RS04775	COG0375	protein maturation
HCU35_RS04785	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCU35_RS04790	COG0651	ATP synthesis coupled electron transport
HCU35_RS04795	COG0650	Formate hydrogenlyase subunit 4
HCU35_RS04800	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HCU35_RS04800	COG3261	NADH dehydrogenase
HCU35_RS04805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCU35_RS04810	COG3260	NADH ubiquinone oxidoreductase 20
HCU35_RS04820	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HCU35_RS04825	COG2723	6-phospho-beta-galactosidase activity
HCU35_RS04830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU35_RS04830	COG1263	PTS System
HCU35_RS04835	COG1609	Transcriptional regulator
HCU35_RS04840	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCU35_RS04845	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HCU35_RS04850	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HCU35_RS04855	COG0446	pyridine nucleotide-disulphide oxidoreductase
HCU35_RS04860	COG1773	rubredoxin
HCU35_RS04860	COG0426	domain, Protein
HCU35_RS04865	COG3604	Transcriptional regulator
HCU35_RS04875	COG1349	DNA-binding transcription factor activity
HCU35_RS04880	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS04885	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS04895	COG3732	PTS system glucitol sorbitol-specific
HCU35_RS04900	COG3730	PTS system glucitol sorbitol-specific
HCU35_RS04905	COG2951	lytic endotransglycosylase activity
HCU35_RS04915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCU35_RS04925	COG1546	Belongs to the CinA family
HCU35_RS04940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCU35_RS04945	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HCU35_RS04975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCU35_RS04980	COG1238	metal cluster binding
HCU35_RS04985	COG2918	glutathione biosynthetic process
HCU35_RS05000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCU35_RS05005	COG2814	Major facilitator Superfamily
HCU35_RS05010	COG1566	PFAM secretion protein HlyD family protein
HCU35_RS05015	COG1846	Transcriptional regulator
HCU35_RS05020	COG2814	Major facilitator Superfamily
HCU35_RS05030	COG4176	ABC-type proline glycine betaine transport system permease component
HCU35_RS05035	COG4175	Glycine betaine
HCU35_RS05050	COG1780	Probably involved in ribonucleotide reductase function
HCU35_RS05060	COG4575	ribosome binding
HCU35_RS05085	COG0401	homolog of Blt101
HCU35_RS05090	COG0583	DNA-binding transcription factor activity
HCU35_RS05095	COG0666	response to abiotic stimulus
HCU35_RS05100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HCU35_RS05105	COG1304	FMN binding
HCU35_RS05115	COG0549	Belongs to the carbamate kinase family
HCU35_RS05120	COG0402	S-adenosylhomocysteine deaminase activity
HCU35_RS05125	COG2226	methyltransferase
HCU35_RS05140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCU35_RS05145	COG3093	addiction module antidote protein HigA
HCU35_RS05150	COG3549	Plasmid maintenance system killer
HCU35_RS05155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCU35_RS05185	COG2226	methyltransferase
HCU35_RS05185	COG1073	alpha beta
HCU35_RS05190	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS05195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCU35_RS05200	COG2814	Major facilitator Superfamily
HCU35_RS05220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCU35_RS05275	COG1215	transferase activity, transferring glycosyl groups
HCU35_RS05300	COG2003	Belongs to the UPF0758 family
HCU35_RS05335	COG4983	Phage plasmid primase, P4 family domain protein
HCU35_RS05340	COG3311	Transcriptional regulator
HCU35_RS05375	COG0582	viral genome integration into host DNA
HCU35_RS05390	COG2867	negative regulation of translational initiation
HCU35_RS05405	COG0497	DNA recombination
HCU35_RS05410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCU35_RS05415	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HCU35_RS05420	COG4536	flavin adenine dinucleotide binding
HCU35_RS05425	COG4137	Cytochrome C assembly protein
HCU35_RS05430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HCU35_RS05440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HCU35_RS05445	COG0336	Belongs to the RNA methyltransferase TrmD family
HCU35_RS05465	COG2885	chlorophyll binding
HCU35_RS05470	COG2199	diguanylate cyclase activity
HCU35_RS05485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HCU35_RS05490	COG1605	Chorismate mutase
HCU35_RS05490	COG0287	Prephenate dehydrogenase
HCU35_RS05540	COG4695	Portal protein
HCU35_RS05630	COG5301	cellulose 1,4-beta-cellobiosidase activity
HCU35_RS05685	COG1605	Chorismate mutase
HCU35_RS05685	COG0077	Prephenate dehydratase
HCU35_RS05695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCU35_RS05700	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCU35_RS05705	COG0564	pseudouridine synthase activity
HCU35_RS05715	COG0542	response to heat
HCU35_RS05745	COG0477	Major facilitator Superfamily
HCU35_RS05750	COG5544	Lipoprotein
HCU35_RS05755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCU35_RS05760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU35_RS05760	COG1042	CoA-binding domain protein
HCU35_RS05760	COG0045	succinate-CoA ligase (ADP-forming) activity
HCU35_RS05765	COG3148	PFAM DTW domain containing protein
HCU35_RS05770	COG3118	belongs to the thioredoxin family
HCU35_RS05775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCU35_RS05780	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HCU35_RS05785	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HCU35_RS05790	COG0513	Belongs to the DEAD box helicase family
HCU35_RS05795	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HCU35_RS05800	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCU35_RS05810	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HCU35_RS05820	COG3086	response to oxidative stress
HCU35_RS05855	COG3179	chitinase
HCU35_RS05905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCU35_RS05915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCU35_RS05920	COG0675	Transposase, IS605 OrfB family
HCU35_RS05935	COG0681	Belongs to the peptidase S26 family
HCU35_RS05950	COG1381	Involved in DNA repair and RecF pathway recombination
HCU35_RS05955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HCU35_RS05965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCU35_RS05970	COG1737	Transcriptional regulator
HCU35_RS05975	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HCU35_RS05980	COG1263	PTS System
HCU35_RS05980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU35_RS05985	COG0560	Phosphoserine phosphatase
HCU35_RS05995	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HCU35_RS06000	COG0047	phosphoribosylformylglycinamidine synthase activity
HCU35_RS06000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCU35_RS06005	COG2205	protein histidine kinase activity
HCU35_RS06010	COG3170	Tfp pilus assembly protein FimV
HCU35_RS06015	COG2204	response regulator
HCU35_RS06020	COG0347	Belongs to the P(II) protein family
HCU35_RS06025	COG1017	nitric oxide dioxygenase activity
HCU35_RS06025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCU35_RS06035	COG2259	Doxx family
HCU35_RS06040	COG2814	Major facilitator Superfamily
HCU35_RS06045	COG3711	transcriptional antiterminator
HCU35_RS06055	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HCU35_RS06070	COG1959	2 iron, 2 sulfur cluster binding
HCU35_RS06075	COG1104	cysteine desulfurase activity
HCU35_RS06080	COG0822	iron-sulfur transferase activity
HCU35_RS06085	COG0316	Belongs to the HesB IscA family
HCU35_RS06090	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HCU35_RS06095	COG0443	Heat shock 70 kDa protein
HCU35_RS06100	COG0633	Ferredoxin
HCU35_RS06105	COG2975	iron-sulfur cluster assembly
HCU35_RS06110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HCU35_RS06120	COG1737	Transcriptional regulator
HCU35_RS06125	COG2897	thiosulfate sulfurtransferase activity
HCU35_RS06140	COG2373	Large extracellular alpha-helical protein
HCU35_RS06145	COG4953	penicillin-binding protein 1C
HCU35_RS06150	COG0243	molybdopterin cofactor binding
HCU35_RS06155	COG0437	4 iron, 4 sulfur cluster binding
HCU35_RS06175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HCU35_RS06190	COG0124	histidyl-tRNA synthetase
HCU35_RS06195	COG2976	Protein conserved in bacteria
HCU35_RS06205	COG1160	GTP binding
HCU35_RS06220	COG1645	bacterial-type flagellum-dependent swarming motility
HCU35_RS06235	COG1570	exodeoxyribonuclease VII activity
HCU35_RS06240	COG0516	GMP reductase activity
HCU35_RS06240	COG0517	IMP dehydrogenase activity
HCU35_RS06275	COG0745	RESPONSE REGULATOR receiver
HCU35_RS06280	COG3713	MltA-interacting MipA family protein
HCU35_RS06300	COG2200	EAL domain
HCU35_RS06315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCU35_RS06325	COG2723	6-phospho-beta-galactosidase activity
HCU35_RS06330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HCU35_RS06335	COG2233	PERMEase
HCU35_RS06345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HCU35_RS06350	COG1446	asparaginase
HCU35_RS06365	COG1393	Belongs to the ArsC family
HCU35_RS06370	COG4783	chaperone-mediated protein folding
HCU35_RS06375	COG0628	permease
HCU35_RS06380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCU35_RS06385	COG2716	regulation of RNA biosynthetic process
HCU35_RS06395	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HCU35_RS06400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HCU35_RS06405	COG2321	neutral zinc metallopeptidase
HCU35_RS06415	COG0400	carboxylic ester hydrolase activity
HCU35_RS06425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCU35_RS06430	COG1393	Belongs to the ArsC family
HCU35_RS06440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCU35_RS06445	COG3850	Histidine kinase
HCU35_RS06450	COG0493	'glutamate synthase
HCU35_RS06450	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCU35_RS06455	COG0494	nUDIX hydrolase
HCU35_RS06460	COG5342	invasion associated locus B
HCU35_RS06465	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HCU35_RS06465	COG3408	Glycogen debranching enzyme
HCU35_RS06475	COG0531	amino acid
HCU35_RS06480	COG2731	YhcH YjgK YiaL family protein
HCU35_RS06485	COG3250	beta-galactosidase activity
HCU35_RS06490	COG1609	Transcriptional regulator
HCU35_RS06495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCU35_RS06500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCU35_RS06515	COG0408	coproporphyrinogen oxidase activity
HCU35_RS06540	COG2837	iron assimilation
HCU35_RS06545	COG4150	thiosulfate binding
HCU35_RS06550	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HCU35_RS06555	COG4208	sulfate ABC transporter
HCU35_RS06560	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HCU35_RS06585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS06600	COG3115	cell septum assembly
HCU35_RS06605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCU35_RS06610	COG3530	Putative quorum-sensing-regulated virulence factor
HCU35_RS06615	COG0385	Bile acid
HCU35_RS06620	COG0583	DNA-binding transcription factor activity
HCU35_RS06650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCU35_RS06655	COG3415	Transposase
HCU35_RS06660	COG3415	Transposase
HCU35_RS06675	COG2199	diguanylate cyclase activity
HCU35_RS06675	COG2200	EAL domain
HCU35_RS06680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCU35_RS06685	COG1914	H( )-stimulated, divalent metal cation uptake system
HCU35_RS06695	COG0667	Aldo Keto reductase
HCU35_RS06700	COG3961	Belongs to the TPP enzyme family
HCU35_RS06710	COG0837	glucose binding
HCU35_RS06715	COG3279	Response regulator of the LytR AlgR family
HCU35_RS06720	COG3275	phosphorelay sensor kinase activity
HCU35_RS06725	COG0436	Aminotransferase
HCU35_RS06735	COG1560	Kdo2-lipid A biosynthetic process
HCU35_RS06740	COG3706	GGDEF domain
HCU35_RS06750	COG2116	formate transmembrane transporter activity
HCU35_RS06760	COG2067	long-chain fatty acid transport protein
HCU35_RS06765	COG3691	Protein conserved in bacteria
HCU35_RS06775	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCU35_RS06775	COG1024	Enoyl-CoA hydratase
HCU35_RS06780	COG2062	phosphohistidine phosphatase, SixA
HCU35_RS06785	COG2840	Smr protein MutS2
HCU35_RS06795	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HCU35_RS06805	COG0730	response to heat
HCU35_RS06810	COG3101	peptidyl-lysine hydroxylation
HCU35_RS06820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCU35_RS06820	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HCU35_RS06825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCU35_RS06840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCU35_RS06845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCU35_RS06850	COG0101	tRNA pseudouridine synthase activity
HCU35_RS06855	COG0586	Pfam SNARE associated Golgi protein
HCU35_RS06865	COG0285	dihydrofolate synthase activity
HCU35_RS06870	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HCU35_RS06875	COG1286	toxin biosynthetic process
HCU35_RS06880	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HCU35_RS06885	COG0163	prenyltransferase activity
HCU35_RS06895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCU35_RS06905	COG4160	amino acid transport
HCU35_RS06910	COG4598	ABC transporter
HCU35_RS06915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU35_RS06920	COG1090	epimerase
HCU35_RS06925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCU35_RS06930	COG0625	glutathione transferase activity
HCU35_RS06935	COG0625	glutathione transferase activity
HCU35_RS06940	COG0622	Phosphoesterase
HCU35_RS06950	COG1609	Transcriptional regulator
HCU35_RS06955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS06965	COG3037	sugar-specific permease SgaT UlaA
HCU35_RS06970	COG3959	Transketolase, thiamine diphosphate binding domain
HCU35_RS06975	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCU35_RS07000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCU35_RS07005	COG0490	domain, Protein
HCU35_RS07005	COG0471	metal ion transport
HCU35_RS07015	COG0436	Aminotransferase
HCU35_RS07020	COG0583	DNA-binding transcription factor activity
HCU35_RS07025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCU35_RS07055	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HCU35_RS07065	COG0839	Belongs to the complex I subunit 6 family
HCU35_RS07070	COG0713	ATP synthesis coupled electron transport
HCU35_RS07075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCU35_RS07080	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCU35_RS07085	COG1007	ATP synthesis coupled electron transport
HCU35_RS07090	COG0784	Response regulator, receiver
HCU35_RS07090	COG0835	chemotaxis
HCU35_RS07095	COG1234	tRNA 3'-trailer cleavage
HCU35_RS07100	COG2153	protein acetylation
HCU35_RS07105	COG4575	ribosome binding
HCU35_RS07110	COG1169	isochorismate synthase
HCU35_RS07115	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HCU35_RS07120	COG0596	Alpha beta hydrolase
HCU35_RS07130	COG1441	menaquinone biosynthetic process
HCU35_RS07175	COG0247	lactate metabolic process
HCU35_RS07180	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HCU35_RS07185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCU35_RS07190	COG2271	Major facilitator Superfamily
HCU35_RS07195	COG0584	glycerophosphoryl diester phosphodiesterase
HCU35_RS07200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCU35_RS07215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCU35_RS07235	COG2198	Histidine kinase
HCU35_RS07235	COG0642	Histidine kinase
HCU35_RS07240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HCU35_RS07250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCU35_RS07250	COG2169	Transcriptional regulator
HCU35_RS07260	COG4615	Cyclic peptide transporter
HCU35_RS07265	COG2239	Acts as a magnesium transporter
HCU35_RS07270	COG0659	secondary active sulfate transmembrane transporter activity
HCU35_RS07275	COG0579	oxidoreductase
HCU35_RS07285	COG3182	Iron-regulated membrane protein
HCU35_RS07300	COG3082	Protein of unknown function (DUF1414)
HCU35_RS07305	COG3081	Nucleoid-associated protein
HCU35_RS07315	COG1061	Type III restriction enzyme res subunit
HCU35_RS07320	COG1187	pseudouridine synthase activity
HCU35_RS07325	COG2814	Major facilitator Superfamily
HCU35_RS07335	COG4172	Belongs to the ABC transporter superfamily
HCU35_RS07340	COG4239	(ABC) transporter, permease
HCU35_RS07345	COG4174	ABC transporter (Permease)
HCU35_RS07350	COG4166	transmembrane transport
HCU35_RS07355	COG2200	EAL domain
HCU35_RS07360	COG0791	NLP P60 protein
HCU35_RS07365	COG0671	phosphoesterase, PA-phosphatase related
HCU35_RS07370	COG0523	cobalamin synthesis protein
HCU35_RS07375	COG0246	Mannitol dehydrogenase
HCU35_RS07380	COG1312	Catalyzes the dehydration of D-mannonate
HCU35_RS07385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HCU35_RS07405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS07405	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS07410	COG1105	Belongs to the carbohydrate kinase PfkB family
HCU35_RS07415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU35_RS07415	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HCU35_RS07415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU35_RS07420	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HCU35_RS07425	COG2855	membrane
HCU35_RS07430	COG0583	DNA-binding transcription factor activity
HCU35_RS07435	COG0833	amino acid
HCU35_RS07440	COG4771	TonB-dependent receptor
HCU35_RS07445	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HCU35_RS07450	COG0477	Major facilitator Superfamily
HCU35_RS07460	COG2311	Membrane
HCU35_RS07475	COG1129	ABC transporter
HCU35_RS07485	COG2949	membrane
HCU35_RS07490	COG0295	cytidine deaminase activity
HCU35_RS07495	COG1346	cytolysis
HCU35_RS07505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCU35_RS07510	COG1538	Outer membrane efflux protein
HCU35_RS07515	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS07520	COG0586	Pfam SNARE associated Golgi protein
HCU35_RS07530	COG1686	Belongs to the peptidase S11 family
HCU35_RS07540	COG0277	FAD linked oxidase domain protein
HCU35_RS07545	COG1472	Belongs to the glycosyl hydrolase 3 family
HCU35_RS07550	COG1732	Glycine betaine
HCU35_RS07555	COG1174	glycine betaine transport
HCU35_RS07560	COG1125	glycine betaine transport
HCU35_RS07565	COG1174	glycine betaine transport
HCU35_RS07575	COG0789	Transcriptional regulator
HCU35_RS07580	COG3275	phosphorelay sensor kinase activity
HCU35_RS07590	COG4807	Protein conserved in bacteria
HCU35_RS07600	COG0489	protein tyrosine kinase activity
HCU35_RS07610	COG5455	response to cobalt ion
HCU35_RS07615	COG1596	polysaccharide export
HCU35_RS07620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCU35_RS07625	COG3206	protein involved in exopolysaccharide biosynthesis
HCU35_RS07625	COG0489	protein tyrosine kinase activity
HCU35_RS07630	COG0076	glutamate decarboxylase activity
HCU35_RS07635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCU35_RS07655	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HCU35_RS07660	COG0351	phosphomethylpyrimidine kinase
HCU35_RS07665	COG2188	Transcriptional regulator
HCU35_RS07670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCU35_RS07675	COG1397	ADP-ribosylglycohydrolase
HCU35_RS07680	COG2211	Major facilitator Superfamily
HCU35_RS07685	COG1830	Aldolase
HCU35_RS07695	COG1070	Carbohydrate kinase
HCU35_RS07710	COG2390	Transcriptional regulator
HCU35_RS07720	COG1070	Carbohydrate kinase
HCU35_RS07730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCU35_RS07735	COG4948	Mandelate Racemase Muconate Lactonizing
HCU35_RS07740	COG0747	negative chemotaxis
HCU35_RS07745	COG0601	transmembrane transport
HCU35_RS07750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCU35_RS07755	COG0444	Belongs to the ABC transporter superfamily
HCU35_RS07760	COG4608	Belongs to the ABC transporter superfamily
HCU35_RS07765	COG1597	lipid kinase activity
HCU35_RS07770	COG0826	peptidase U32
HCU35_RS07775	COG0745	RESPONSE REGULATOR receiver
HCU35_RS07780	COG2205	protein histidine kinase activity
HCU35_RS07785	COG0477	Major facilitator Superfamily
HCU35_RS07790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCU35_RS07795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCU35_RS07800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCU35_RS07805	COG0443	Heat shock 70 kDa protein
HCU35_RS07810	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HCU35_RS07815	COG5002	protein histidine kinase activity
HCU35_RS07815	COG3447	MASE1 domain protein
HCU35_RS07815	COG5001	Diguanylate cyclase
HCU35_RS07825	COG0717	Belongs to the dCTP deaminase family
HCU35_RS07830	COG2982	Protein involved in outer membrane biogenesis
HCU35_RS07835	COG1253	flavin adenine dinucleotide binding
HCU35_RS07850	COG3206	protein involved in exopolysaccharide biosynthesis
HCU35_RS07850	COG0489	protein tyrosine kinase activity
HCU35_RS07855	COG0463	Glycosyl transferase, family 2
HCU35_RS07860	COG1045	serine acetyltransferase
HCU35_RS07865	COG0438	transferase activity, transferring glycosyl groups
HCU35_RS07875	COG1216	Glycosyl transferase, family 2
HCU35_RS07880	COG0110	maltose O-acetyltransferase activity
HCU35_RS07885	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HCU35_RS07890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCU35_RS07895	COG1051	belongs to the nudix hydrolase family
HCU35_RS07900	COG0297	glycogen (starch) synthase activity
HCU35_RS07910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCU35_RS07915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCU35_RS07920	COG2244	polysaccharide biosynthetic process
HCU35_RS07925	COG2327	Polysaccharide pyruvyl transferase
HCU35_RS07930	COG0438	transferase activity, transferring glycosyl groups
HCU35_RS07945	COG2244	polysaccharide biosynthetic process
HCU35_RS07955	COG0438	transferase activity, transferring glycosyl groups
HCU35_RS07970	COG0438	transferase activity, transferring glycosyl groups
HCU35_RS07975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCU35_RS07980	COG1088	dTDP-glucose 4,6-dehydratase activity
HCU35_RS08010	COG0107	imidazoleglycerol-phosphate synthase activity
HCU35_RS08015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HCU35_RS08020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HCU35_RS08030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCU35_RS08040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HCU35_RS08050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCU35_RS08055	COG0583	DNA-binding transcription factor activity
HCU35_RS08065	COG0531	amino acid
HCU35_RS08070	COG2925	Exonuclease
HCU35_RS08080	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HCU35_RS08085	COG1289	transmembrane transporter activity
HCU35_RS08100	COG0534	Mate efflux family protein
HCU35_RS08110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HCU35_RS08115	COG0477	Major facilitator Superfamily
HCU35_RS08130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCU35_RS08140	COG0589	response to stress
HCU35_RS08150	COG1376	ErfK ybiS ycfS ynhG family protein
HCU35_RS08175	COG0737	Belongs to the 5'-nucleotidase family
HCU35_RS08180	COG0737	Belongs to the 5'-nucleotidase family
HCU35_RS08245	COG0583	DNA-binding transcription factor activity
HCU35_RS08270	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HCU35_RS08270	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HCU35_RS08290	COG4565	transcriptional regulatory protein
HCU35_RS08295	COG3290	protein histidine kinase activity
HCU35_RS08305	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HCU35_RS08310	COG1418	mRNA catabolic process
HCU35_RS08315	COG0270	DNA (cytosine-5-)-methyltransferase activity
HCU35_RS08320	COG3727	T/G mismatch-specific endonuclease activity
HCU35_RS08325	COG0697	spore germination
HCU35_RS08330	COG2354	Protein conserved in bacteria
HCU35_RS08335	COG5475	Uncharacterized small protein (DUF2158)
HCU35_RS08360	COG2197	response regulator
HCU35_RS08370	COG1987	bacterial-type flagellum assembly
HCU35_RS08410	COG1157	protein secretion by the type III secretion system
HCU35_RS08420	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCU35_RS08430	COG1677	Flagellar hook-basal body complex protein FliE
HCU35_RS08440	COG0366	Alpha amylase catalytic
HCU35_RS08450	COG1516	flagellar protein fliS
HCU35_RS08455	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HCU35_RS08460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCU35_RS08475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCU35_RS08485	COG0765	amino acid transport
HCU35_RS08490	COG1126	abc transporter atp-binding protein
HCU35_RS08495	COG2197	response regulator
HCU35_RS08505	COG2197	response regulator
HCU35_RS08545	COG0583	DNA-binding transcription factor activity
HCU35_RS08580	COG3318	Belongs to the UPF0149 family
HCU35_RS08580	COG3012	SEC-C Motif Domain Protein
HCU35_RS08585	COG0814	amino acid
HCU35_RS08595	COG1528	Iron-storage protein
HCU35_RS08625	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HCU35_RS08630	COG1528	Iron-storage protein
HCU35_RS08640	COG1879	ABC-type sugar transport system periplasmic component
HCU35_RS08650	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCU35_RS08660	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HCU35_RS08700	COG1301	dicarboxylic acid transport
HCU35_RS08735	COG0840	transmembrane signaling receptor activity
HCU35_RS08750	COG0745	RESPONSE REGULATOR receiver
HCU35_RS08780	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HCU35_RS08785	COG0018	arginyl-trna synthetase
HCU35_RS08790	COG3102	Protein conserved in bacteria
HCU35_RS08795	COG3142	Participates in the control of copper homeostasis
HCU35_RS08800	COG0500	methyltransferase
HCU35_RS08805	COG2226	methyltransferase
HCU35_RS08810	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HCU35_RS08815	COG1801	Protein of unknown function DUF72
HCU35_RS08820	COG1335	isochorismatase
HCU35_RS08830	COG0494	nUDIX hydrolase
HCU35_RS08845	COG0632	four-way junction helicase activity
HCU35_RS08850	COG2255	four-way junction helicase activity
HCU35_RS08855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCU35_RS08865	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HCU35_RS08870	COG0739	heme binding
HCU35_RS08875	COG1560	Kdo2-lipid A biosynthetic process
HCU35_RS08885	COG1737	Transcriptional regulator
HCU35_RS08890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HCU35_RS08895	COG0129	dihydroxy-acid dehydratase activity
HCU35_RS08900	COG0800	Aldolase
HCU35_RS08910	COG2979	Protein of unknown function (DUF533)
HCU35_RS08915	COG1770	oligopeptidase
HCU35_RS08920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCU35_RS08925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCU35_RS08935	COG2372	response to copper ion
HCU35_RS08940	COG1276	copper resistance
HCU35_RS08955	COG2990	Protein conserved in bacteria
HCU35_RS08970	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HCU35_RS08970	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HCU35_RS08975	COG3008	intermembrane lipid transfer
HCU35_RS08980	COG2995	paraquat-inducible protein a
HCU35_RS08985	COG1956	GAF domain-containing protein
HCU35_RS08990	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HCU35_RS09000	COG0501	Belongs to the peptidase M48B family
HCU35_RS09005	COG2814	Major facilitator Superfamily
HCU35_RS09010	COG1414	Transcriptional regulator
HCU35_RS09040	COG0768	penicillin binding
HCU35_RS09045	COG2226	methyltransferase
HCU35_RS09050	COG1971	Probably functions as a manganese efflux pump
HCU35_RS09055	COG4811	Protein of unknown function (DUF986)
HCU35_RS09060	COG3716	PTS system mannose fructose sorbose family IID component
HCU35_RS09065	COG3715	PTS system
HCU35_RS09070	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS09070	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU35_RS09075	COG1253	flavin adenine dinucleotide binding
HCU35_RS09080	COG2200	EAL domain
HCU35_RS09085	COG1760	l-serine dehydratase
HCU35_RS09090	COG0494	nUDIX hydrolase
HCU35_RS09105	COG0251	oxidation-reduction process
HCU35_RS09110	COG1199	ATP-dependent helicase activity
HCU35_RS09115	COG1214	PFAM Peptidase M22, glycoprotease
HCU35_RS09120	COG3065	identical protein binding
HCU35_RS09125	COG0318	PFAM AMP-dependent synthetase and ligase
HCU35_RS09130	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HCU35_RS09135	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HCU35_RS09140	COG2894	cell division
HCU35_RS09145	COG0850	regulation of cytokinetic process
HCU35_RS09155	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCU35_RS09160	COG2983	Belongs to the UPF0260 family
HCU35_RS09170	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCU35_RS09180	COG2719	SpoVR family
HCU35_RS09185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCU35_RS09190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCU35_RS09195	COG3263	regulation of cellular component size
HCU35_RS09200	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCU35_RS09205	COG0741	lytic transglycosylase activity
HCU35_RS09215	COG4774	siderophore transport
HCU35_RS09235	COG4977	sequence-specific DNA binding
HCU35_RS09350	COG0515	serine threonine protein kinase
HCU35_RS09375	COG3209	COG3209 Rhs family protein
HCU35_RS09430	COG5444	nuclease activity
HCU35_RS09445	COG3209	COG3209 Rhs family protein
HCU35_RS09455	COG0012	GTP binding
HCU35_RS09460	COG0193	aminoacyl-tRNA hydrolase activity
HCU35_RS09475	COG0659	secondary active sulfate transmembrane transporter activity
HCU35_RS09485	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HCU35_RS09495	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HCU35_RS09505	COG2890	protein-(glutamine-N5) methyltransferase activity
HCU35_RS09520	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HCU35_RS09525	COG0387	Pfam Sodium calcium exchanger
HCU35_RS09530	COG4572	Cation transport regulator
HCU35_RS09535	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HCU35_RS09545	COG0840	transmembrane signaling receptor activity
HCU35_RS09550	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HCU35_RS09555	COG3707	response regulator
HCU35_RS09560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCU35_RS09570	COG1116	anion transmembrane transporter activity
HCU35_RS09575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCU35_RS09575	COG2146	nitrite reductase [NAD(P)H] activity
HCU35_RS09580	COG0243	molybdopterin cofactor binding
HCU35_RS09585	COG4932	domain protein
HCU35_RS09590	COG2197	response regulator
HCU35_RS09595	COG3850	Histidine kinase
HCU35_RS09600	COG2223	nitrite transmembrane transporter activity
HCU35_RS09605	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HCU35_RS09610	COG1140	nitrate reductase beta subunit
HCU35_RS09615	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HCU35_RS09620	COG2181	nitrate reductase activity
HCU35_RS09635	COG0788	formyltetrahydrofolate deformylase activity
HCU35_RS09640	COG3012	SEC-C Motif Domain Protein
HCU35_RS09645	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCU35_RS09650	COG0745	RESPONSE REGULATOR receiver
HCU35_RS09655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCU35_RS09670	COG1435	thymidine kinase activity
HCU35_RS09675	COG1012	belongs to the aldehyde dehydrogenase family
HCU35_RS09675	COG1454	alcohol dehydrogenase
HCU35_RS09680	COG2095	MarC family integral membrane protein
HCU35_RS09700	COG0444	Belongs to the ABC transporter superfamily
HCU35_RS09705	COG4608	Belongs to the ABC transporter superfamily
HCU35_RS09710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCU35_RS09715	COG3099	Belongs to the UPF0263 family
HCU35_RS09735	COG1280	lysine exporter protein (LysE YggA)
HCU35_RS09740	COG2350	Protein conserved in bacteria
HCU35_RS09770	COG0727	PFAM Uncharacterised protein family (UPF0153)
HCU35_RS09775	COG3047	cAMP biosynthetic process
HCU35_RS09780	COG0425	Belongs to the sulfur carrier protein TusA family
HCU35_RS09785	COG2391	methyltransferase activity
HCU35_RS09790	COG0159	tryptophan synthase activity
HCU35_RS09795	COG0133	tryptophan synthase activity
HCU35_RS09805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCU35_RS09805	COG0512	Glutamine amidotransferase of anthranilate synthase
HCU35_RS09825	COG0009	L-threonylcarbamoyladenylate synthase
HCU35_RS09835	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HCU35_RS09840	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS09845	COG0616	signal peptide processing
HCU35_RS09875	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HCU35_RS09885	COG0671	phosphoesterase, PA-phosphatase related
HCU35_RS09890	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HCU35_RS09895	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HCU35_RS09900	COG0284	orotidine-5'-phosphate decarboxylase activity
HCU35_RS09905	COG0023	Translation Initiation Factor
HCU35_RS09915	COG1349	DNA-binding transcription factor activity
HCU35_RS09925	COG1024	Enoyl-CoA hydratase
HCU35_RS09930	COG5001	Diguanylate cyclase
HCU35_RS09940	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCU35_RS09940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCU35_RS09945	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HCU35_RS09950	COG3706	GGDEF domain
HCU35_RS09955	COG2207	Transcriptional regulator
HCU35_RS09955	COG3708	Transcriptional regulator
HCU35_RS09960	COG0251	oxidation-reduction process
HCU35_RS09970	COG4172	Belongs to the ABC transporter superfamily
HCU35_RS09980	COG4171	peptide transport system, permease
HCU35_RS09995	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HCU35_RS10000	COG1842	Phage shock protein A
HCU35_RS10010	COG1983	PspC domain protein
HCU35_RS10020	COG0366	Alpha amylase catalytic
HCU35_RS10025	COG1653	transport
HCU35_RS10030	COG1175	transmembrane transport
HCU35_RS10035	COG0395	ABC-type sugar transport system, permease component
HCU35_RS10040	COG1063	alcohol dehydrogenase
HCU35_RS10045	COG1082	Xylose isomerase domain protein TIM barrel
HCU35_RS10050	COG0673	inositol 2-dehydrogenase activity
HCU35_RS10055	COG1554	hydrolase, family 65, central catalytic
HCU35_RS10060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCU35_RS10065	COG3842	ATPase activity
HCU35_RS10075	COG1609	Transcriptional regulator
HCU35_RS10080	COG3106	COG3106 Predicted ATPase
HCU35_RS10085	COG3768	UPF0283 membrane protein
HCU35_RS10095	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HCU35_RS10100	COG4948	Mandelate Racemase Muconate Lactonizing
HCU35_RS10105	COG2866	Carboxypeptidase
HCU35_RS10110	COG4166	transmembrane transport
HCU35_RS10220	COG0840	transmembrane signaling receptor activity
HCU35_RS10235	COG0513	Belongs to the DEAD box helicase family
HCU35_RS10245	COG0582	viral genome integration into host DNA
HCU35_RS10260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HCU35_RS10265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCU35_RS10265	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HCU35_RS10265	COG0674	pyruvate-flavodoxin oxidoreductase activity
HCU35_RS10265	COG1013	pyruvate-flavodoxin oxidoreductase activity
HCU35_RS10270	COG3042	response to heat
HCU35_RS10275	COG3187	Heat shock protein
HCU35_RS10285	COG1294	oxidase, subunit
HCU35_RS10290	COG1271	oxidase subunit
HCU35_RS10300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCU35_RS10305	COG1012	belongs to the aldehyde dehydrogenase family
HCU35_RS10315	COG3615	Tellurite resistance protein tehB
HCU35_RS10320	COG3615	Tellurite resistance protein tehB
HCU35_RS10350	COG0747	negative chemotaxis
HCU35_RS10360	COG3238	Protein conserved in bacteria
HCU35_RS10365	COG1247	-acetyltransferase
HCU35_RS10375	COG2130	NADP-dependent
HCU35_RS10380	COG1802	Transcriptional regulator
HCU35_RS10385	COG4772	TonB-dependent receptor
HCU35_RS10415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCU35_RS10420	COG1473	amidohydrolase
HCU35_RS10425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCU35_RS10430	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HCU35_RS10445	COG1126	abc transporter atp-binding protein
HCU35_RS10455	COG0625	glutathione transferase activity
HCU35_RS10460	COG1942	4-Oxalocrotonate Tautomerase
HCU35_RS10465	COG1560	Kdo2-lipid A biosynthetic process
HCU35_RS10475	COG0640	Transcriptional regulator
HCU35_RS10480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCU35_RS10485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCU35_RS10490	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HCU35_RS10495	COG2181	nitrate reductase activity
HCU35_RS10500	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HCU35_RS10505	COG1140	nitrate reductase beta subunit
HCU35_RS10510	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HCU35_RS10515	COG2223	nitrite transmembrane transporter activity
HCU35_RS10545	COG0437	4 iron, 4 sulfur cluster binding
HCU35_RS10550	COG2864	formate dehydrogenase
HCU35_RS10570	COG2814	Major facilitator Superfamily
HCU35_RS10575	COG1252	NADH dehydrogenase
HCU35_RS10585	COG1064	alcohol dehydrogenase
HCU35_RS10590	COG0488	(ABC) transporter
HCU35_RS10595	COG0281	malic enzyme
HCU35_RS10625	COG1764	response to oxidative stress
HCU35_RS10635	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS10640	COG4608	Belongs to the ABC transporter superfamily
HCU35_RS10645	COG0444	Belongs to the ABC transporter superfamily
HCU35_RS10650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCU35_RS10655	COG0601	transmembrane transport
HCU35_RS10660	COG0747	negative chemotaxis
HCU35_RS10665	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HCU35_RS10680	COG2200	EAL domain
HCU35_RS10710	COG0840	transmembrane signaling receptor activity
HCU35_RS10725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCU35_RS10730	COG1649	PFAM Uncharacterised BCR, COG1649
HCU35_RS10735	COG4628	conserved protein (DUF2132)
HCU35_RS10740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCU35_RS10745	COG0583	DNA-binding transcription factor activity
HCU35_RS10755	COG0583	DNA-binding transcription factor activity
HCU35_RS10765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCU35_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS10780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCU35_RS10815	COG2814	Major facilitator Superfamily
HCU35_RS10820	COG0583	DNA-binding transcription factor activity
HCU35_RS10870	COG1349	DNA-binding transcription factor activity
HCU35_RS10875	COG0494	nUDIX hydrolase
HCU35_RS10900	COG0596	Alpha beta hydrolase
HCU35_RS10935	COG3781	membrane
HCU35_RS10940	COG0246	Mannitol dehydrogenase
HCU35_RS10950	COG3706	GGDEF domain
HCU35_RS10960	COG2066	Belongs to the glutaminase family
HCU35_RS10970	COG1012	belongs to the aldehyde dehydrogenase family
HCU35_RS10975	COG0583	DNA-binding transcription factor activity
HCU35_RS10990	COG2814	Major facilitator Superfamily
HCU35_RS11000	COG1846	Transcriptional regulator
HCU35_RS11015	COG0697	spore germination
HCU35_RS11020	COG2814	Major facilitator Superfamily
HCU35_RS11025	COG3443	Belongs to the bacterial solute-binding protein 9 family
HCU35_RS11035	COG1129	ABC transporter
HCU35_RS11055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCU35_RS11080	COG0826	peptidase U32
HCU35_RS11085	COG1396	sequence-specific DNA binding
HCU35_RS11090	COG3135	benzoate transporter
HCU35_RS11110	COG0747	negative chemotaxis
HCU35_RS11115	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCU35_RS11120	COG0500	methyltransferase
HCU35_RS11125	COG1275	C4-dicarboxylate transporter malic acid transport protein
HCU35_RS11130	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCU35_RS11135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU35_RS11140	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HCU35_RS11150	COG0436	Aminotransferase
HCU35_RS11160	COG2272	Belongs to the type-B carboxylesterase lipase family
HCU35_RS11165	COG5383	Protein conserved in bacteria
HCU35_RS11170	COG0583	DNA-binding transcription factor activity
HCU35_RS11175	COG0840	transmembrane signaling receptor activity
HCU35_RS11230	COG2274	protein secretion by the type I secretion system
HCU35_RS11245	COG1349	DNA-binding transcription factor activity
HCU35_RS11250	COG0673	inositol 2-dehydrogenase activity
HCU35_RS11255	COG3038	cytochrome b561
HCU35_RS11260	COG1012	belongs to the aldehyde dehydrogenase family
HCU35_RS11265	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HCU35_RS11280	COG1538	Outer membrane efflux protein
HCU35_RS11285	COG1643	Atp-dependent helicase
HCU35_RS11295	COG0564	pseudouridine synthase activity
HCU35_RS11300	COG3122	Protein conserved in bacteria
HCU35_RS11340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HCU35_RS11350	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HCU35_RS11355	COG0300	oxidoreductase activity
HCU35_RS11375	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HCU35_RS11385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCU35_RS11390	COG3327	negative regulation of DNA-templated transcription, initiation
HCU35_RS11395	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HCU35_RS11400	COG0183	Belongs to the thiolase family
HCU35_RS11405	COG2050	protein possibly involved in aromatic compounds catabolism
HCU35_RS11410	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCU35_RS11415	COG1024	Enoyl-CoA hydratase
HCU35_RS11420	COG1024	Enoyl-CoA hydratase
HCU35_RS11425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCU35_RS11430	COG2151	metal-sulfur cluster biosynthetic enzyme
HCU35_RS11435	COG3396	Phenylacetate-CoA oxygenase
HCU35_RS11440	COG3460	Phenylacetate-CoA oxygenase
HCU35_RS11445	COG3396	Phenylacetate-CoA oxygenase
HCU35_RS11450	COG2030	dehydratase
HCU35_RS11450	COG1012	belongs to the aldehyde dehydrogenase family
HCU35_RS11455	COG3733	amine oxidase
HCU35_RS11460	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HCU35_RS11465	COG3706	GGDEF domain
HCU35_RS11465	COG2203	Gaf domain
HCU35_RS11465	COG4251	negative regulation of phosphorylation
HCU35_RS11465	COG5001	Diguanylate cyclase
HCU35_RS11470	COG1012	belongs to the aldehyde dehydrogenase family
HCU35_RS11475	COG2207	Transcriptional regulator
HCU35_RS11480	COG3784	Protein of unknown function (DUF1318)
HCU35_RS11490	COG2911	Protein conserved in bacteria
HCU35_RS11495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCU35_RS11515	COG4993	Dehydrogenase
HCU35_RS11525	COG0814	amino acid
HCU35_RS11535	COG1176	ABC-type spermidine putrescine transport system, permease component I
HCU35_RS11540	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCU35_RS11550	COG4773	Receptor
HCU35_RS11565	COG4221	oxidoreductase activity
HCU35_RS11570	COG1802	Transcriptional regulator
HCU35_RS11575	COG0589	response to stress
HCU35_RS11585	COG0246	Mannitol dehydrogenase
HCU35_RS11595	COG1904	glucuronate isomerase
HCU35_RS11600	COG0477	Major facilitator Superfamily
HCU35_RS11605	COG1063	alcohol dehydrogenase
HCU35_RS11610	COG4948	Mandelate Racemase Muconate Lactonizing
HCU35_RS11625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU35_RS11650	COG0437	4 iron, 4 sulfur cluster binding
HCU35_RS11655	COG3302	dmso reductase anchor subunit
HCU35_RS11660	COG3381	protein complex oligomerization
HCU35_RS11665	COG3141	response to X-ray
HCU35_RS11725	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HCU35_RS11730	COG1940	carbohydrate kinase activity
HCU35_RS11735	COG0583	DNA-binding transcription factor activity
HCU35_RS11740	COG2814	Major facilitator Superfamily
HCU35_RS11745	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HCU35_RS11755	COG3591	Belongs to the peptidase S1B family
HCU35_RS11760	COG2076	Multidrug Resistance protein
HCU35_RS11765	COG2076	Multidrug Resistance protein
HCU35_RS11770	COG0628	permease
HCU35_RS11780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCU35_RS11785	COG1403	HNH endonuclease
HCU35_RS11795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCU35_RS11835	COG4993	Dehydrogenase
HCU35_RS11850	COG0667	Aldo Keto reductase
HCU35_RS11860	COG2840	Smr protein MutS2
HCU35_RS11865	COG0583	DNA-binding transcription factor activity
HCU35_RS11875	COG1473	amidohydrolase
HCU35_RS11880	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HCU35_RS11885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCU35_RS11895	COG0589	response to stress
HCU35_RS11900	COG0668	transmembrane transport
HCU35_RS11905	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HCU35_RS11910	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HCU35_RS11920	COG0531	amino acid
HCU35_RS11925	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS11930	COG3136	membrane protein required for alginate biosynthesis
HCU35_RS11935	COG0745	RESPONSE REGULATOR receiver
HCU35_RS11945	COG1278	Cold shock
HCU35_RS11955	COG2205	protein histidine kinase activity
HCU35_RS11970	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HCU35_RS11970	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HCU35_RS11980	COG5339	Protein conserved in bacteria
HCU35_RS11995	COG1609	Transcriptional regulator
HCU35_RS12000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU35_RS12000	COG1263	PTS System
HCU35_RS12005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HCU35_RS12010	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HCU35_RS12015	COG0673	inositol 2-dehydrogenase activity
HCU35_RS12065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HCU35_RS12070	COG3104	oligopeptide transport
HCU35_RS12075	COG0625	glutathione transferase activity
HCU35_RS12080	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HCU35_RS12085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCU35_RS12090	COG0259	pyridoxamine-phosphate oxidase activity
HCU35_RS12095	COG3895	Periplasmic Protein
HCU35_RS12100	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HCU35_RS12110	COG3706	GGDEF domain
HCU35_RS12125	COG1566	PFAM secretion protein HlyD family protein
HCU35_RS12130	COG1289	transmembrane transporter activity
HCU35_RS12135	COG2032	superoxide dismutase activity
HCU35_RS12140	COG4989	oxidoreductase activity
HCU35_RS12145	COG3313	Fe-S protein
HCU35_RS12150	COG2194	sulfuric ester hydrolase activity
HCU35_RS12155	COG1309	transcriptional regulator
HCU35_RS12160	COG1902	pentaerythritol trinitrate reductase activity
HCU35_RS12165	COG0346	lactoylglutathione lyase activity
HCU35_RS12175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HCU35_RS12180	COG0791	NLP P60 protein
HCU35_RS12190	COG2814	Major facilitator Superfamily
HCU35_RS12205	COG0583	DNA-binding transcription factor activity
HCU35_RS12210	COG2814	Major facilitator Superfamily
HCU35_RS12215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HCU35_RS12220	COG0307	riboflavin synthase, alpha
HCU35_RS12240	COG0071	Belongs to the small heat shock protein (HSP20) family
HCU35_RS12250	COG4529	Protein conserved in bacteria
HCU35_RS12260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCU35_RS12280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCU35_RS12290	COG0765	amino acid transport
HCU35_RS12295	COG0765	amino acid transport
HCU35_RS12305	COG1464	Belongs to the NlpA lipoprotein family
HCU35_RS12310	COG2011	ABC-type metal ion transport system permease component
HCU35_RS12325	COG0626	cystathionine gamma-synthase activity
HCU35_RS12340	COG1376	ErfK ybiS ycfS ynhG family protein
HCU35_RS12345	COG2166	iron-sulfur cluster assembly
HCU35_RS12350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCU35_RS12355	COG0719	Fe-S assembly protein
HCU35_RS12360	COG0396	ATPase activity
HCU35_RS12365	COG0719	Fe-S assembly protein
HCU35_RS12370	COG0316	Belongs to the HesB IscA family
HCU35_RS12385	COG0789	Transcriptional regulator
HCU35_RS12390	COG2200	EAL domain
HCU35_RS12410	COG3383	formate dehydrogenase (NAD+) activity
HCU35_RS12435	COG3121	Chaperone
HCU35_RS12450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCU35_RS12460	COG2050	protein possibly involved in aromatic compounds catabolism
HCU35_RS12465	COG0277	FAD linked oxidase domain protein
HCU35_RS12465	COG0247	lactate metabolic process
HCU35_RS12470	COG0628	permease
HCU35_RS12480	COG1472	Belongs to the glycosyl hydrolase 3 family
HCU35_RS12485	COG2211	Major facilitator Superfamily
HCU35_RS12490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCU35_RS12490	COG0574	Belongs to the PEP-utilizing enzyme family
HCU35_RS12495	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HCU35_RS12500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HCU35_RS12505	COG4256	Hemin uptake protein
HCU35_RS12515	COG3720	iron ion transport
HCU35_RS12520	COG4558	Periplasmic binding protein
HCU35_RS12525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU35_RS12535	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HCU35_RS12545	COG0791	NLP P60 protein
HCU35_RS12555	COG0386	Belongs to the glutathione peroxidase family
HCU35_RS12565	COG0776	regulation of translation
HCU35_RS12570	COG0072	phenylalanine-tRNA ligase activity
HCU35_RS12570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCU35_RS12575	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCU35_RS12620	COG3137	Salt-induced outer membrane protein
HCU35_RS12625	COG1105	Belongs to the carbohydrate kinase PfkB family
HCU35_RS12635	COG3001	Fructosamine kinase
HCU35_RS12645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCU35_RS12650	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS12655	COG1988	membrane-bound metal-dependent
HCU35_RS12660	COG1823	symporter activity
HCU35_RS12670	COG0753	catalase activity
HCU35_RS12675	COG3394	polysaccharide catabolic process
HCU35_RS12680	COG1486	melibiose metabolic process
HCU35_RS12685	COG2169	Transcriptional regulator
HCU35_RS12685	COG1917	Cupin 2, conserved barrel domain protein
HCU35_RS12690	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCU35_RS12695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU35_RS12700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU35_RS12705	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCU35_RS12715	COG0322	excinuclease ABC activity
HCU35_RS12725	COG3678	ATP-independent chaperone mediated protein folding
HCU35_RS12735	COG3724	N-succinylarginine dihydrolase activity
HCU35_RS12740	COG1012	belongs to the aldehyde dehydrogenase family
HCU35_RS12745	COG3138	arginine N-succinyltransferase
HCU35_RS12755	COG0708	Exodeoxyribonuclease III
HCU35_RS12765	COG4134	Bacterial extracellular solute-binding protein
HCU35_RS12770	COG4135	transport system, permease component
HCU35_RS12775	COG4136	ATPase activity
HCU35_RS12780	COG2897	thiosulfate sulfurtransferase activity
HCU35_RS12785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HCU35_RS12790	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCU35_RS12795	COG0494	nUDIX hydrolase
HCU35_RS12810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCU35_RS12815	COG0709	Synthesizes selenophosphate from selenide and ATP
HCU35_RS12820	COG0778	Nitroreductase
HCU35_RS12825	COG0616	signal peptide processing
HCU35_RS12830	COG0252	asparaginase activity
HCU35_RS12835	COG1335	isochorismatase
HCU35_RS12845	COG3139	Protein of unknown function (DUF1315)
HCU35_RS12865	COG3713	MltA-interacting MipA family protein
HCU35_RS12870	COG2766	serine protein kinase
HCU35_RS12875	COG2718	Belongs to the UPF0229 family
HCU35_RS12880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCU35_RS12885	COG2211	Major facilitator Superfamily
HCU35_RS12895	COG2707	UPF0756 membrane protein
HCU35_RS12900	COG2207	Transcriptional regulator
HCU35_RS12905	COG2807	transmembrane transport
HCU35_RS12910	COG0504	CTP synthase activity
HCU35_RS12915	COG3189	MarR family transcriptional regulator
HCU35_RS12925	COG3042	response to heat
HCU35_RS12930	COG2199	diguanylate cyclase activity
HCU35_RS12930	COG2203	Gaf domain
HCU35_RS12945	COG2261	transglycosylase associated protein
HCU35_RS12955	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HCU35_RS12965	COG0538	isocitrate dehydrogenase activity
HCU35_RS12970	COG1187	pseudouridine synthase activity
HCU35_RS12985	COG2915	High frequency lysogenization protein hflD homolog
HCU35_RS12990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCU35_RS13005	COG2205	protein histidine kinase activity
HCU35_RS13010	COG2850	peptidyl-arginine hydroxylation
HCU35_RS13015	COG1943	Transposase
HCU35_RS13045	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HCU35_RS13055	COG4591	ABC-type transport system involved in lipoprotein release permease component
HCU35_RS13060	COG1136	(ABC) transporter
HCU35_RS13065	COG4591	ABC-type transport system involved in lipoprotein release permease component
HCU35_RS13070	COG4763	Acyl-transferase
HCU35_RS13075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HCU35_RS13080	COG1388	LysM domain
HCU35_RS13080	COG1376	ErfK ybiS ycfS ynhG family protein
HCU35_RS13090	COG1309	transcriptional regulator
HCU35_RS13095	COG3134	Outer membrane lipoprotein
HCU35_RS13100	COG1252	NADH dehydrogenase
HCU35_RS13105	COG3150	esterase
HCU35_RS13120	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HCU35_RS13125	COG5633	Lipoprotein
HCU35_RS13130	COG0537	adenosine 5'-monophosphoramidase activity
HCU35_RS13135	COG4773	Receptor
HCU35_RS13145	COG0084	hydrolase, TatD family'
HCU35_RS13150	COG0470	DNA polymerase III
HCU35_RS13155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HCU35_RS13160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCU35_RS13165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCU35_RS13170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCU35_RS13175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCU35_RS13190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCU35_RS13195	COG0416	fatty acid biosynthetic process
HCU35_RS13200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HCU35_RS13210	COG0424	maF-like protein
HCU35_RS13215	COG0564	pseudouridine synthase activity
HCU35_RS13220	COG1530	ribonuclease E activity
HCU35_RS13225	COG0583	DNA-binding transcription factor activity
HCU35_RS13230	COG2814	Major facilitator Superfamily
HCU35_RS13240	COG1256	bacterial-type flagellum assembly
HCU35_RS13260	COG4786	Flagellar basal body rod
HCU35_RS13270	COG1749	Flagellar hook protein flgE
HCU35_RS13280	COG1558	bacterial-type flagellum-dependent cell motility
HCU35_RS13315	COG3132	Protein of unknown function, DUF480
HCU35_RS13320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU35_RS13325	COG0477	Major facilitator Superfamily
HCU35_RS13335	COG0418	dihydroorotase activity
HCU35_RS13360	COG3038	cytochrome b561
HCU35_RS13365	COG2353	YceI-like domain
HCU35_RS13370	COG1054	Belongs to the UPF0176 family
HCU35_RS13375	COG1560	Kdo2-lipid A biosynthetic process
HCU35_RS13390	COG5645	(Lipo)protein
HCU35_RS13395	COG2943	transferase activity, transferring hexosyl groups
HCU35_RS13410	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HCU35_RS13460	COG3381	protein complex oligomerization
HCU35_RS13465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HCU35_RS13470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCU35_RS13480	COG0583	DNA-binding transcription factor activity
HCU35_RS13490	COG1335	isochorismatase
HCU35_RS13500	COG1115	amino acid carrier protein
HCU35_RS13505	COG1702	phosphate starvation-inducible protein PhoH
HCU35_RS13515	COG2822	iron ion transport
HCU35_RS13525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCU35_RS13535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCU35_RS13540	COG0506	proline dehydrogenase activity
HCU35_RS13540	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HCU35_RS13540	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HCU35_RS13550	COG1309	transcriptional regulator
HCU35_RS13555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCU35_RS13560	COG1335	isochorismatase
HCU35_RS13565	COG0251	oxidation-reduction process
HCU35_RS13570	COG2267	carboxylic ester hydrolase activity
HCU35_RS13575	COG0778	Nitroreductase
HCU35_RS13580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCU35_RS13585	COG2233	PERMEase
HCU35_RS13595	COG3729	General stress protein
HCU35_RS13620	COG1733	regulation of RNA biosynthetic process
HCU35_RS13625	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS13630	COG0586	Pfam SNARE associated Golgi protein
HCU35_RS13635	COG2239	Acts as a magnesium transporter
HCU35_RS13650	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HCU35_RS13650	COG3264	Mechanosensitive ion channel
HCU35_RS13660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU35_RS13665	COG1120	ATPase activity
HCU35_RS13680	COG0670	Belongs to the BI1 family
HCU35_RS13690	COG1254	Belongs to the acylphosphatase family
HCU35_RS13695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HCU35_RS13705	COG1832	CoA-binding protein
HCU35_RS13710	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HCU35_RS13715	COG1803	Methylglyoxal synthase
HCU35_RS13720	COG0210	DNA helicase
HCU35_RS13725	COG3304	Inner membrane component domain
HCU35_RS13730	COG1289	transmembrane transporter activity
HCU35_RS13735	COG3070	regulator of competence-specific genes
HCU35_RS13740	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
HCU35_RS13750	COG3120	sequence-specific DNA binding
HCU35_RS13755	COG1067	ATP-dependent peptidase activity
HCU35_RS13765	COG3130	regulation of translation
HCU35_RS13770	COG3009	Protein conserved in bacteria
HCU35_RS13775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HCU35_RS13775	COG3008	intermembrane lipid transfer
HCU35_RS13780	COG2995	paraquat-inducible protein a
HCU35_RS13785	COG0488	(ABC) transporter
HCU35_RS13790	COG0116	Belongs to the methyltransferase superfamily
HCU35_RS13790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HCU35_RS13795	COG0633	Ferredoxin
HCU35_RS13795	COG3217	Mosc domain protein beta barrel domain protein
HCU35_RS13805	COG0167	dihydroorotate dehydrogenase activity
HCU35_RS13810	COG0431	NADPH-dependent FMN reductase
HCU35_RS13815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCU35_RS13820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCU35_RS13825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCU35_RS13835	COG0308	aminopeptidase N
HCU35_RS13840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HCU35_RS13845	COG0017	Asparaginyl-tRNA synthetase
HCU35_RS13855	COG1448	Aminotransferase
HCU35_RS13860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCU35_RS13865	COG3108	Peptidase M15
HCU35_RS13870	COG2989	Protein conserved in bacteria
HCU35_RS13875	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HCU35_RS13880	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HCU35_RS13890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCU35_RS13895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HCU35_RS13900	COG3173	Aminoglycoside phosphotransferase
HCU35_RS13905	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HCU35_RS13910	COG2835	tetraacyldisaccharide 4'-kinase activity
HCU35_RS13915	COG3214	Protein conserved in bacteria
HCU35_RS13925	COG1132	(ABC) transporter
HCU35_RS13930	COG0658	competence protein
HCU35_RS13930	COG2333	competence protein COMEC
HCU35_RS13935	COG0776	regulation of translation
HCU35_RS13940	COG0539	negative regulation of cytoplasmic translation
HCU35_RS13945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HCU35_RS13950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HCU35_RS13955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HCU35_RS13960	COG2323	membrane
HCU35_RS13965	COG1944	ATP diphosphatase activity
HCU35_RS13970	COG2116	formate transmembrane transporter activity
HCU35_RS13975	COG1882	Formate acetyltransferase
HCU35_RS13980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HCU35_RS13990	COG0477	Major facilitator Superfamily
HCU35_RS13995	COG3302	dmso reductase anchor subunit
HCU35_RS14000	COG0437	4 iron, 4 sulfur cluster binding
HCU35_RS14005	COG0243	molybdopterin cofactor binding
HCU35_RS14010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HCU35_RS14015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HCU35_RS14020	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HCU35_RS14025	COG1178	ABC-type Fe3 transport system permease component
HCU35_RS14025	COG1674	ftsk spoiiie
HCU35_RS14035	COG0492	ferredoxin-NADP+ reductase activity
HCU35_RS14040	COG4988	ABC transporter
HCU35_RS14045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HCU35_RS14050	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HCU35_RS14055	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HCU35_RS14060	COG0542	response to heat
HCU35_RS14065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HCU35_RS14070	COG1278	Cold shock
HCU35_RS14080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCU35_RS14085	COG2990	Protein conserved in bacteria
HCU35_RS14090	COG3593	DNA synthesis involved in DNA repair
HCU35_RS14100	COG2431	L-lysine efflux transmembrane transporter activity
HCU35_RS14105	COG1151	hydroxylamine reductase activity
HCU35_RS14110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCU35_RS14115	COG0028	Belongs to the TPP enzyme family
HCU35_RS14120	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HCU35_RS14125	COG0702	epimerase
HCU35_RS14130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCU35_RS14135	COG3397	chitin binding
HCU35_RS14150	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HCU35_RS14175	COG2165	general secretion pathway protein
HCU35_RS14185	COG2165	general secretion pathway protein
HCU35_RS14195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HCU35_RS14200	COG1450	Type ii and iii secretion system protein
HCU35_RS14205	COG3031	protein transport across the cell outer membrane
HCU35_RS14225	COG3023	N-Acetylmuramoyl-L-alanine amidase
HCU35_RS14230	COG0393	Putative heavy-metal-binding
HCU35_RS14240	COG1126	abc transporter atp-binding protein
HCU35_RS14245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCU35_RS14250	COG4215	(ABC) transporter
HCU35_RS14255	COG4160	amino acid transport
HCU35_RS14260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCU35_RS14265	COG5002	protein histidine kinase activity
HCU35_RS14270	COG0745	RESPONSE REGULATOR receiver
HCU35_RS14275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCU35_RS14285	COG1177	transmembrane transport
HCU35_RS14290	COG1176	ABC-type spermidine putrescine transport system, permease component I
HCU35_RS14295	COG3842	ATPase activity
HCU35_RS14300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HCU35_RS14315	COG0778	Nitroreductase
HCU35_RS14345	COG0640	Transcriptional regulator
HCU35_RS14350	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCU35_RS14355	COG1393	Belongs to the ArsC family
HCU35_RS14360	COG3226	Transcriptional regulator
HCU35_RS14365	COG0738	Major facilitator superfamily
HCU35_RS14370	COG0561	phosphatase activity
HCU35_RS14375	COG2814	Major facilitator Superfamily
HCU35_RS14385	COG0671	phosphoesterase, PA-phosphatase related
HCU35_RS14390	COG1349	DNA-binding transcription factor activity
HCU35_RS14395	COG1686	Belongs to the peptidase S11 family
HCU35_RS14400	COG0625	glutathione transferase activity
HCU35_RS14405	COG2133	pyrroloquinoline quinone binding
HCU35_RS14440	COG1446	asparaginase
HCU35_RS14445	COG0303	'Molybdopterin
HCU35_RS14455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCU35_RS14460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HCU35_RS14465	COG1882	Formate acetyltransferase
HCU35_RS14470	COG0561	phosphatase activity
HCU35_RS14480	COG1609	Transcriptional regulator
HCU35_RS14485	COG2271	Major facilitator Superfamily
HCU35_RS14495	COG0488	(ABC) transporter
HCU35_RS14500	COG1376	ErfK ybiS ycfS ynhG family protein
HCU35_RS14505	COG2188	Transcriptional regulator
HCU35_RS14510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU35_RS14515	COG2723	6-phospho-beta-galactosidase activity
HCU35_RS14520	COG1538	Outer membrane efflux protein
HCU35_RS14530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCU35_RS14545	COG2382	esterase
HCU35_RS14550	COG2819	hydrolase of the alpha beta superfamily
HCU35_RS14560	COG0667	Aldo Keto reductase
HCU35_RS14570	COG2814	Major facilitator Superfamily
HCU35_RS14575	COG1566	PFAM secretion protein HlyD family protein
HCU35_RS14580	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCU35_RS14585	COG1321	iron dependent repressor
HCU35_RS14595	COG2194	sulfuric ester hydrolase activity
HCU35_RS14600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HCU35_RS14610	COG0783	Belongs to the Dps family
HCU35_RS14615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCU35_RS14620	COG0765	amino acid transport
HCU35_RS14625	COG1126	abc transporter atp-binding protein
HCU35_RS14630	COG0668	transmembrane transport
HCU35_RS14635	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HCU35_RS14645	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCU35_RS14655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCU35_RS14660	COG3539	Fimbrial protein
HCU35_RS14665	COG3121	Chaperone
HCU35_RS14685	COG1199	ATP-dependent helicase activity
HCU35_RS14690	COG0513	Belongs to the DEAD box helicase family
HCU35_RS14695	COG1309	transcriptional regulator
HCU35_RS14700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCU35_RS14710	COG0842	Transport permease protein
HCU35_RS14715	COG0842	Transport permease protein
HCU35_RS14725	COG3568	Endonuclease Exonuclease Phosphatase
HCU35_RS14730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCU35_RS14735	COG0392	lysyltransferase activity
HCU35_RS14740	COG0670	Belongs to the BI1 family
HCU35_RS14745	COG0314	molybdopterin synthase activity
HCU35_RS14750	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HCU35_RS14755	COG0315	cyclic pyranopterin monophosphate synthase activity
HCU35_RS14760	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCU35_RS14790	COG2226	methyltransferase
HCU35_RS14795	COG0156	8-amino-7-oxononanoate synthase activity
HCU35_RS14800	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HCU35_RS14805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCU35_RS14810	COG1881	PFAM PEBP family protein
HCU35_RS14815	COG2986	histidine ammonia-lyase
HCU35_RS14820	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HCU35_RS14830	COG0010	Belongs to the arginase family
HCU35_RS14840	COG4677	pectinesterase activity
HCU35_RS14845	COG2706	6-phosphogluconolactonase activity
HCU35_RS14850	COG0561	phosphatase activity
HCU35_RS14860	COG4149	molybdate abc transporter
HCU35_RS14865	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCU35_RS14875	COG2005	Transcriptional regulator
HCU35_RS14875	COG3585	molybdate ion transport
HCU35_RS14880	COG1119	ATPase activity
HCU35_RS14885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCU35_RS14890	COG1085	galactose-1-phosphate uridylyltransferase
HCU35_RS14895	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HCU35_RS14900	COG2017	converts alpha-aldose to the beta-anomer
HCU35_RS14910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HCU35_RS14920	COG1230	cation diffusion facilitator family transporter
HCU35_RS14925	COG3201	nicotinamide mononucleotide transporter
HCU35_RS14960	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HCU35_RS14965	COG2885	chlorophyll binding
HCU35_RS14970	COG0823	Involved in the tonB-independent uptake of proteins
HCU35_RS14975	COG3064	Membrane
HCU35_RS14980	COG0848	biopolymer transport protein
HCU35_RS14985	COG0811	peptide transport
HCU35_RS14990	COG0824	Thioesterase
HCU35_RS14995	COG3790	cyd operon protein YbgE
HCU35_RS15000	COG4890	Cyd operon protein YbgT
HCU35_RS15005	COG1294	oxidase, subunit
HCU35_RS15010	COG1271	oxidase subunit
HCU35_RS15015	COG0383	alpha-mannosidase activity
HCU35_RS15020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU35_RS15020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU35_RS15020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS15025	COG2188	Transcriptional regulator
HCU35_RS15030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HCU35_RS15035	COG0045	succinate-CoA ligase (ADP-forming) activity
HCU35_RS15040	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCU35_RS15045	COG0567	Dehydrogenase, E1 component
HCU35_RS15050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCU35_RS15055	COG1053	succinate dehydrogenase
HCU35_RS15060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HCU35_RS15065	COG2009	succinate dehydrogenase
HCU35_RS15070	COG0372	Belongs to the citrate synthase family
HCU35_RS15075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCU35_RS15085	COG1984	allophanate hydrolase subunit 2
HCU35_RS15090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HCU35_RS15095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCU35_RS15115	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HCU35_RS15120	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HCU35_RS15125	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HCU35_RS15130	COG2205	protein histidine kinase activity
HCU35_RS15135	COG0745	RESPONSE REGULATOR receiver
HCU35_RS15145	COG1982	Orn Lys Arg decarboxylase major
HCU35_RS15150	COG0531	amino acid
HCU35_RS15155	COG0033	Phosphoglucomutase
HCU35_RS15160	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HCU35_RS15165	COG0596	Alpha beta hydrolase
HCU35_RS15180	COG0735	belongs to the Fur family
HCU35_RS15195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCU35_RS15200	COG1263	PTS System
HCU35_RS15200	COG2190	(PTS) system
HCU35_RS15200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU35_RS15210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HCU35_RS15215	COG1846	Transcriptional regulator
HCU35_RS15215	COG1940	carbohydrate kinase activity
HCU35_RS15220	COG0647	UMP catabolic process
HCU35_RS15225	COG0367	asparagine synthase
HCU35_RS15265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCU35_RS15270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCU35_RS15275	COG1702	phosphate starvation-inducible protein PhoH
HCU35_RS15280	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HCU35_RS15300	COG0765	amino acid transport
HCU35_RS15305	COG0765	amino acid transport
HCU35_RS15310	COG1126	abc transporter atp-binding protein
HCU35_RS15315	COG1957	nucleoside hydrolase
HCU35_RS15320	COG2888	peptidyl-tyrosine sulfation
HCU35_RS15335	COG1466	dna polymerase III delta subunit
HCU35_RS15345	COG0799	negative regulation of ribosome biogenesis
HCU35_RS15355	COG0768	penicillin binding
HCU35_RS15360	COG0772	Belongs to the SEDS family
HCU35_RS15365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCU35_RS15370	COG1686	Belongs to the peptidase S11 family
HCU35_RS15380	COG0321	lipoyl(octanoyl) transferase activity
HCU35_RS15385	COG0583	DNA-binding transcription factor activity
HCU35_RS15390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HCU35_RS15395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCU35_RS15400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCU35_RS15420	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCU35_RS15425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCU35_RS15445	COG3069	C4-dicarboxylate transmembrane transporter activity
HCU35_RS15450	COG3719	Belongs to the RNase T2 family
HCU35_RS15455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU35_RS15460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU35_RS15465	COG0006	proline dipeptidase activity
HCU35_RS15470	COG1363	Peptidase, m42
HCU35_RS15475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS15475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCU35_RS15475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS15480	COG2207	Transcriptional regulator
HCU35_RS15490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCU35_RS15495	COG1063	alcohol dehydrogenase
HCU35_RS15515	COG0583	DNA-binding transcription factor activity
HCU35_RS15520	COG3969	phosphoadenosine phosphosulfate
HCU35_RS15525	COG1475	DNA binding
HCU35_RS15530	COG0436	Aminotransferase
HCU35_RS15535	COG0235	Class ii aldolase
HCU35_RS15540	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HCU35_RS15555	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HCU35_RS15570	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCU35_RS15575	COG1129	ABC transporter
HCU35_RS15580	COG0371	Dehydrogenase
HCU35_RS15585	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS15600	COG2879	small protein
HCU35_RS15605	COG1966	Carbon starvation protein
HCU35_RS15610	COG2050	protein possibly involved in aromatic compounds catabolism
HCU35_RS15615	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS15620	COG3433	isochorismatase activity
HCU35_RS15620	COG1535	isochorismatase
HCU35_RS15625	COG1021	2,3-dihydroxybenzoate-AMP ligase
HCU35_RS15630	COG1169	isochorismate synthase
HCU35_RS15635	COG4592	Periplasmic binding protein
HCU35_RS15645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU35_RS15650	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU35_RS15655	COG1120	ATPase activity
HCU35_RS15660	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HCU35_RS15660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCU35_RS15665	COG3251	PFAM MbtH domain protein
HCU35_RS15670	COG2382	esterase
HCU35_RS15675	COG4771	TonB-dependent receptor
HCU35_RS15680	COG2977	Belongs to the P-Pant transferase superfamily
HCU35_RS15685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCU35_RS15690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCU35_RS15695	COG1121	(ABC) transporter
HCU35_RS15725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCU35_RS15755	COG0601	transmembrane transport
HCU35_RS15760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCU35_RS15765	COG0444	Belongs to the ABC transporter superfamily
HCU35_RS15770	COG4608	Belongs to the ABC transporter superfamily
HCU35_RS15800	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HCU35_RS15835	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HCU35_RS15865	COG4774	siderophore transport
HCU35_RS15885	COG2315	Protein conserved in bacteria
HCU35_RS15890	COG0778	Nitroreductase
HCU35_RS15910	COG0477	Major facilitator Superfamily
HCU35_RS15915	COG0668	transmembrane transport
HCU35_RS15920	COG1609	Transcriptional regulator
HCU35_RS15935	COG2211	Major facilitator Superfamily
HCU35_RS15940	COG1113	amino acid transport
HCU35_RS16015	COG2501	S4 domain
HCU35_RS16020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU35_RS16020	COG1263	PTS System
HCU35_RS16020	COG2190	(PTS) system
HCU35_RS16025	COG1609	Transcriptional regulator
HCU35_RS16030	COG1988	membrane-bound metal-dependent
HCU35_RS16040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCU35_RS16045	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCU35_RS16050	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCU35_RS16055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HCU35_RS16070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HCU35_RS16075	COG4181	ATPase activity
HCU35_RS16080	COG2755	lipolytic protein G-D-S-L family
HCU35_RS16085	COG0300	oxidoreductase activity
HCU35_RS16090	COG3118	belongs to the thioredoxin family
HCU35_RS16095	COG0390	transport system, permease component
HCU35_RS16100	COG4619	ABC transporter
HCU35_RS16110	COG0330	HflC and HflK could
HCU35_RS16115	COG1585	Membrane protein implicated in regulation of membrane protease activity
HCU35_RS16125	COG2217	Heavy metal translocating P-type atpase
HCU35_RS16130	COG3735	TraB family
HCU35_RS16135	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCU35_RS16140	COG0737	Belongs to the 5'-nucleotidase family
HCU35_RS16145	COG2223	nitrite transmembrane transporter activity
HCU35_RS16150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCU35_RS16150	COG4651	solute:proton antiporter activity
HCU35_RS16155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCU35_RS16160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCU35_RS16170	COG0326	Molecular chaperone. Has ATPase activity
HCU35_RS16175	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HCU35_RS16180	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HCU35_RS16190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCU35_RS16195	COG2832	Protein of unknown function (DUF454)
HCU35_RS16200	COG3923	Primosomal replication protein n
HCU35_RS16210	COG3264	Mechanosensitive ion channel
HCU35_RS16210	COG1196	nuclear chromosome segregation
HCU35_RS16215	COG1309	transcriptional regulator
HCU35_RS16220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCU35_RS16225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCU35_RS16240	COG0110	maltose O-acetyltransferase activity
HCU35_RS16260	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HCU35_RS16270	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HCU35_RS16290	COG1609	Transcriptional regulator
HCU35_RS16295	COG2364	Membrane
HCU35_RS16300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCU35_RS16320	COG3695	enzyme binding
HCU35_RS16325	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HCU35_RS16330	COG1946	Acyl-CoA thioesterase
HCU35_RS16335	COG0004	ammonium transporteR
HCU35_RS16340	COG0347	Belongs to the P(II) protein family
HCU35_RS16345	COG1132	(ABC) transporter
HCU35_RS16350	COG1132	(ABC) transporter
HCU35_RS16355	COG1522	sequence-specific DNA binding
HCU35_RS16365	COG0561	phosphatase activity
HCU35_RS16370	COG4533	DNA binding
HCU35_RS16375	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HCU35_RS16380	COG0824	Thioesterase
HCU35_RS16385	COG1555	photosystem II stabilization
HCU35_RS16390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCU35_RS16395	COG0776	regulation of translation
HCU35_RS16400	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HCU35_RS16415	COG0544	peptidyl-prolyl cis-trans isomerase activity
HCU35_RS16420	COG0271	Belongs to the BolA IbaG family
HCU35_RS16425	COG3056	Lipoprotein
HCU35_RS16430	COG2223	nitrite transmembrane transporter activity
HCU35_RS16435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCU35_RS16440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCU35_RS16445	COG1845	cytochrome c oxidase, subunit III
HCU35_RS16450	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HCU35_RS16455	COG0109	protoheme IX farnesyltransferase activity
HCU35_RS16475	COG1129	ABC transporter
HCU35_RS16480	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCU35_RS16500	COG0235	Class ii aldolase
HCU35_RS16505	COG2814	Major facilitator Superfamily
HCU35_RS16515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCU35_RS16520	COG0693	protein deglycase activity
HCU35_RS16525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU35_RS16530	COG1486	melibiose metabolic process
HCU35_RS16540	COG2188	Transcriptional regulator
HCU35_RS16555	COG0142	geranyltranstransferase activity
HCU35_RS16560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCU35_RS16565	COG0667	Aldo Keto reductase
HCU35_RS16570	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HCU35_RS16575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCU35_RS16580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HCU35_RS16585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCU35_RS16585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCU35_RS16590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HCU35_RS16595	COG4238	major outer membrane lipoprotein
HCU35_RS16600	COG3248	Nucleoside-binding outer membrane protein
HCU35_RS16615	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCU35_RS16620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCU35_RS16625	COG1862	Preprotein translocase
HCU35_RS16640	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HCU35_RS16645	COG0450	alkyl hydroperoxide reductase
HCU35_RS16660	COG0366	Alpha amylase catalytic
HCU35_RS16675	COG5002	protein histidine kinase activity
HCU35_RS16685	COG0420	3'-5' exonuclease activity
HCU35_RS16690	COG0419	ATPase involved in DNA repair
HCU35_RS16695	COG1940	carbohydrate kinase activity
HCU35_RS16705	COG3123	guanosine phosphorylase activity
HCU35_RS16710	COG4126	flavin adenine dinucleotide binding
HCU35_RS16720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCU35_RS16725	COG1671	Belongs to the UPF0178 family
HCU35_RS16730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCU35_RS16735	COG3706	GGDEF domain
HCU35_RS16760	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCU35_RS16780	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HCU35_RS16785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCU35_RS16800	COG0113	porphobilinogen synthase activity
HCU35_RS16810	COG2175	clavaminate synthase activity
HCU35_RS16815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCU35_RS16820	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HCU35_RS16825	COG4521	taurine ABC transporter
HCU35_RS16830	COG2040	homocysteine
HCU35_RS16835	COG0833	amino acid
HCU35_RS16840	COG0628	permease
HCU35_RS16855	COG3300	MHYT domain
HCU35_RS16855	COG5001	Diguanylate cyclase
HCU35_RS16860	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HCU35_RS16950	COG0582	viral genome integration into host DNA
HCU35_RS16980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HCU35_RS16985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCU35_RS16990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HCU35_RS17000	COG1073	alpha beta
HCU35_RS17010	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCU35_RS17015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCU35_RS17020	COG2991	Protein conserved in bacteria
HCU35_RS17035	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HCU35_RS17040	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HCU35_RS17055	COG3034	peptidoglycan biosynthetic process
HCU35_RS17060	COG0121	glutamine amidotransferase
HCU35_RS17075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCU35_RS17085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCU35_RS17095	COG0747	negative chemotaxis
HCU35_RS17100	COG4608	Belongs to the ABC transporter superfamily
HCU35_RS17105	COG0444	Belongs to the ABC transporter superfamily
HCU35_RS17130	COG2226	methyltransferase
HCU35_RS17135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCU35_RS17140	COG0741	lytic transglycosylase activity
HCU35_RS17140	COG1388	LysM domain
HCU35_RS17145	COG2226	methyltransferase
HCU35_RS17150	COG3021	interspecies interaction between organisms
HCU35_RS17155	COG2814	Major facilitator Superfamily
HCU35_RS17160	COG0583	DNA-binding transcription factor activity
HCU35_RS17200	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HCU35_RS17210	COG2011	ABC-type metal ion transport system permease component
HCU35_RS17215	COG1464	Belongs to the NlpA lipoprotein family
HCU35_RS17225	COG1720	tRNA m6t6A37 methyltransferase activity
HCU35_RS17235	COG3015	lipoprotein NlpE involved in copper resistance
HCU35_RS17240	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HCU35_RS17255	COG4568	rho-dependent transcription termination
HCU35_RS17260	COG0037	tRNA processing
HCU35_RS17265	COG0346	lactoylglutathione lyase activity
HCU35_RS17270	COG1982	Orn Lys Arg decarboxylase major
HCU35_RS17275	COG0825	malonyl-CoA metabolic process
HCU35_RS17285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCU35_RS17290	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCU35_RS17295	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCU35_RS17300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCU35_RS17305	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCU35_RS17315	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCU35_RS17320	COG0750	zinc metalloprotease
HCU35_RS17325	COG0575	Belongs to the CDS family
HCU35_RS17335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HCU35_RS17380	COG3835	regulator
HCU35_RS17385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCU35_RS17390	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HCU35_RS17395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HCU35_RS17405	COG2860	membrane
HCU35_RS17410	COG0316	Belongs to the HesB IscA family
HCU35_RS17420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCU35_RS17425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCU35_RS17430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCU35_RS17435	COG1120	ATPase activity
HCU35_RS17440	COG4774	siderophore transport
HCU35_RS17450	COG3188	usher protein
HCU35_RS17455	COG3121	Chaperone
HCU35_RS17465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCU35_RS17470	COG1643	Atp-dependent helicase
HCU35_RS17475	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HCU35_RS17480	COG1489	DNA binding
HCU35_RS17490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCU35_RS17495	COG0617	tRNA 3'-terminal CCA addition
HCU35_RS17500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HCU35_RS17510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HCU35_RS17515	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HCU35_RS17525	COG3121	Chaperone
HCU35_RS17530	COG3188	usher protein
HCU35_RS17535	COG3539	Fimbrial protein
HCU35_RS17555	COG0726	polysaccharide deacetylase
HCU35_RS17560	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS17565	COG0842	Transport permease protein
HCU35_RS17570	COG1131	(ABC) transporter
HCU35_RS17575	COG0288	reversible hydration of carbon dioxide
HCU35_RS17585	COG4993	Dehydrogenase
HCU35_RS17600	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HCU35_RS17620	COG3064	Membrane
HCU35_RS17635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCU35_RS17640	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCU35_RS17645	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HCU35_RS17650	COG2186	Transcriptional regulator
HCU35_RS17655	COG1113	amino acid transport
HCU35_RS17660	COG2211	Major facilitator Superfamily
HCU35_RS17665	COG3940	Belongs to the glycosyl hydrolase 43 family
HCU35_RS17670	COG3725	Membrane protein required for beta-lactamase induction
HCU35_RS17675	COG3023	N-Acetylmuramoyl-L-alanine amidase
HCU35_RS17685	COG4969	Belongs to the N-Me-Phe pilin family
HCU35_RS17690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HCU35_RS17695	COG1459	type II secretion system
HCU35_RS17700	COG0516	GMP reductase activity
HCU35_RS17710	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HCU35_RS17715	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HCU35_RS17720	COG0494	nUDIX hydrolase
HCU35_RS17725	COG0653	protein targeting
HCU35_RS17735	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HCU35_RS17740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCU35_RS17745	COG0849	cell division
HCU35_RS17755	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCU35_RS17770	COG0772	Belongs to the SEDS family
HCU35_RS17780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCU35_RS17785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCU35_RS17790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCU35_RS17795	COG0768	penicillin binding
HCU35_RS17810	COG2001	Belongs to the MraZ family
HCU35_RS17815	COG1609	Transcriptional regulator
HCU35_RS17825	COG0028	Belongs to the TPP enzyme family
HCU35_RS17840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCU35_RS17865	COG2814	Major facilitator Superfamily
HCU35_RS17885	COG1178	ABC-type Fe3 transport system permease component
HCU35_RS17895	COG0586	Pfam SNARE associated Golgi protein
HCU35_RS17905	COG1069	ribulokinase activity
HCU35_RS17910	COG2160	L-arabinose isomerase activity
HCU35_RS17915	COG0235	Class ii aldolase
HCU35_RS17920	COG0417	DNA replication proofreading
HCU35_RS17925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCU35_RS17930	COG0564	pseudouridine synthase activity
HCU35_RS17935	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HCU35_RS17940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HCU35_RS17945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCU35_RS17950	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HCU35_RS17960	COG2967	ApaG domain
HCU35_RS17965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HCU35_RS17975	COG0475	glutathione-regulated potassium exporter activity
HCU35_RS17975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCU35_RS18000	COG0505	Belongs to the CarA family
HCU35_RS18010	COG1609	Transcriptional regulator
HCU35_RS18025	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU35_RS18030	COG3715	PTS system
HCU35_RS18035	COG3716	PTS system mannose fructose sorbose family IID component
HCU35_RS18055	COG1047	Peptidyl-prolyl cis-trans
HCU35_RS18070	COG0196	riboflavin kinase activity
HCU35_RS18075	COG0268	Binds directly to 16S ribosomal RNA
HCU35_RS18080	COG0583	DNA-binding transcription factor activity
HCU35_RS18085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCU35_RS18095	COG0443	Heat shock 70 kDa protein
HCU35_RS18100	COG1584	GPR1 FUN34 yaaH family protein
HCU35_RS18105	COG0477	Major facilitator Superfamily
HCU35_RS18110	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCU35_RS18120	COG1115	amino acid carrier protein
HCU35_RS18135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCU35_RS18145	COG0460	homoserine dehydrogenase
HCU35_RS18145	COG0527	aspartate kinase activity
HCU35_RS18155	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HCU35_RS18165	COG0745	RESPONSE REGULATOR receiver
HCU35_RS18170	COG3045	CreA protein
HCU35_RS18175	COG3708	Transcriptional regulator
HCU35_RS18175	COG2207	Transcriptional regulator
HCU35_RS18180	COG0406	alpha-ribazole phosphatase activity
HCU35_RS18185	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HCU35_RS18190	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HCU35_RS18195	COG0741	lytic transglycosylase activity
HCU35_RS18200	COG0488	(ABC) transporter
HCU35_RS18225	COG0560	Phosphoserine phosphatase
HCU35_RS18230	COG3726	membrane protein affecting hemolysin expression
HCU35_RS18250	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HCU35_RS18260	COG1328	CTP reductase activity
HCU35_RS18265	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HCU35_RS18270	COG0084	hydrolase, TatD family'
HCU35_RS18275	COG4667	esterase of the alpha-beta hydrolase superfamily
HCU35_RS18280	COG5487	UPF0391 membrane protein
HCU35_RS18285	COG2823	Periplasmic or secreted lipoprotein
HCU35_RS18290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HCU35_RS18295	COG1011	Hydrolase
HCU35_RS18300	COG0456	acetyltransferase
HCU35_RS18305	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HCU35_RS18310	COG2813	Specifically methylates the guanine in position
HCU35_RS18340	COG4114	ferric iron reductase
HCU35_RS18345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU35_RS18345	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCU35_RS18350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCU35_RS18355	COG2197	response regulator
HCU35_RS18360	COG2197	response regulator
HCU35_RS18365	COG2966	Psort location CytoplasmicMembrane, score
HCU35_RS18370	COG3610	response to peptide
HCU35_RS18375	COG1846	Transcriptional regulator
HCU35_RS18380	COG1764	response to oxidative stress
HCU35_RS18390	COG1484	DNA-dependent DNA replication
HCU35_RS18410	COG0840	transmembrane signaling receptor activity
HCU35_RS18415	COG1846	Transcriptional regulator
HCU35_RS18420	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCU35_RS18425	COG1012	belongs to the aldehyde dehydrogenase family
HCU35_RS18430	COG3384	dioxygenase
HCU35_RS18440	COG3971	2-oxopent-4-enoate hydratase activity
HCU35_RS18460	COG2368	4-hydroxyphenylacetate
HCU35_RS18465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCU35_RS18470	COG1349	DNA-binding transcription factor activity
HCU35_RS18475	COG1966	Carbon starvation protein
HCU35_RS18480	COG2879	small protein
HCU35_RS18485	COG0523	cobalamin synthesis protein
HCU35_RS18490	COG3307	-O-antigen
HCU35_RS18510	COG1012	belongs to the aldehyde dehydrogenase family
HCU35_RS18525	COG2733	membrane
HCU35_RS18535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCU35_RS18545	COG0640	Transcriptional regulator
HCU35_RS18555	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCU35_RS18565	COG5457	Domain of unknown function (DUF1127)
HCU35_RS18570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCU35_RS18595	COG2850	peptidyl-arginine hydroxylation
HCU35_RS18600	COG0740	serine-type endopeptidase activity
HCU35_RS18605	COG0346	lactoylglutathione lyase activity
HCU35_RS18610	COG4566	intracellular signal transduction
HCU35_RS18615	COG4191	Histidine kinase
HCU35_RS18620	COG2204	response regulator
HCU35_RS18660	COG2211	Major facilitator Superfamily
HCU35_RS18670	COG1609	Transcriptional regulator
HCU35_RS18720	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HCU35_RS18770	COG0582	viral genome integration into host DNA
HCU35_RS18795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HCU35_RS18810	COG1414	Transcriptional regulator
HCU35_RS18815	COG3507	Belongs to the glycosyl hydrolase 43 family
HCU35_RS18820	COG2211	Major facilitator Superfamily
HCU35_RS18825	COG0129	dihydroxy-acid dehydratase activity
HCU35_RS18830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCU35_RS18835	COG2731	YhcH YjgK YiaL family protein
HCU35_RS18840	COG2235	arginine
HCU35_RS18855	COG1288	antiporter activity
HCU35_RS18860	COG1438	arginine binding
HCU35_RS18875	COG0540	Belongs to the ATCase OTCase family
HCU35_RS18885	COG0251	oxidation-reduction process
HCU35_RS18890	COG3397	chitin binding
HCU35_RS18895	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HCU35_RS18905	COG1609	Transcriptional regulator
HCU35_RS18910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCU35_RS18910	COG1263	PTS System
HCU35_RS18915	COG0366	Alpha amylase catalytic
HCU35_RS18935	COG0383	alpha-mannosidase activity
HCU35_RS18940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS18940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU35_RS18940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU35_RS18950	COG0602	queuosine metabolic process
HCU35_RS18955	COG3711	transcriptional antiterminator
HCU35_RS18955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS18975	COG3964	amidohydrolase
HCU35_RS19015	COG0312	modulator of DNA gyrase
HCU35_RS19020	COG3028	Belongs to the UPF0307 family
HCU35_RS19025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCU35_RS19040	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCU35_RS19045	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCU35_RS19050	COG1129	ABC transporter
HCU35_RS19055	COG1879	ABC-type sugar transport system periplasmic component
HCU35_RS19065	COG2105	PFAM AIG2 family protein
HCU35_RS19070	COG2911	Protein conserved in bacteria
HCU35_RS19075	COG0729	surface antigen
HCU35_RS19080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCU35_RS19085	COG1609	Transcriptional regulator
HCU35_RS19090	COG0673	inositol 2-dehydrogenase activity
HCU35_RS19095	COG0673	inositol 2-dehydrogenase activity
HCU35_RS19105	COG0673	inositol 2-dehydrogenase activity
HCU35_RS19110	COG2211	Major facilitator Superfamily
HCU35_RS19115	COG1253	flavin adenine dinucleotide binding
HCU35_RS19125	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HCU35_RS19130	COG1218	3'(2'),5'-bisphosphate nucleotidase
HCU35_RS19140	COG1733	regulation of RNA biosynthetic process
HCU35_RS19145	COG0702	epimerase
HCU35_RS19155	COG0697	spore germination
HCU35_RS19160	COG0840	transmembrane signaling receptor activity
HCU35_RS19170	COG1113	amino acid transport
HCU35_RS19175	COG0545	Peptidyl-prolyl cis-trans isomerase
HCU35_RS19180	COG3061	Opacity-associated protein A
HCU35_RS19185	COG0697	spore germination
HCU35_RS19190	COG0359	binds to the 23S rRNA
HCU35_RS19195	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCU35_RS19200	COG2965	DNA replication, synthesis of RNA primer
HCU35_RS19240	COG3037	sugar-specific permease SgaT UlaA
HCU35_RS19255	COG1073	alpha beta
HCU35_RS19260	COG3650	response to hydrogen peroxide
HCU35_RS19275	COG1960	acyl-CoA dehydrogenase activity
HCU35_RS19280	COG0477	Major facilitator Superfamily
HCU35_RS19285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCU35_RS19290	COG0557	exoribonuclease II activity
HCU35_RS19295	COG1959	2 iron, 2 sulfur cluster binding
HCU35_RS19305	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HCU35_RS19310	COG0330	HflC and HflK could
HCU35_RS19315	COG0330	HflC and HflK could
HCU35_RS19320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCU35_RS19325	COG1923	regulation of RNA biosynthetic process
HCU35_RS19330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HCU35_RS19335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HCU35_RS19345	COG0802	atpase or kinase
HCU35_RS19350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HCU35_RS19350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HCU35_RS19355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HCU35_RS19390	COG1511	domain protein
HCU35_RS19390	COG3264	Mechanosensitive ion channel
HCU35_RS19400	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HCU35_RS19405	COG1053	succinate dehydrogenase
HCU35_RS19410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCU35_RS19415	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HCU35_RS19425	COG0583	DNA-binding transcription factor activity
HCU35_RS19450	COG5510	response to toxic substance
HCU35_RS19475	COG3366	ferrous iron transmembrane transporter activity
HCU35_RS19480	COG0700	Nucleoside recognition
HCU35_RS19485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HCU35_RS19490	COG0459	protein refolding
HCU35_RS19500	COG0531	amino acid
HCU35_RS19505	COG3030	protein affecting phage T7 exclusion by the F plasmid
HCU35_RS19510	COG1027	Aspartate ammonia-lyase
HCU35_RS19515	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HCU35_RS19530	COG1309	transcriptional regulator
HCU35_RS19550	COG3647	Membrane
HCU35_RS19575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCU35_RS19585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCU35_RS19590	COG0009	L-threonylcarbamoyladenylate synthase
HCU35_RS19595	COG0551	DNA topoisomerase type I activity
HCU35_RS19600	COG2922	Belongs to the Smg family
HCU35_RS19605	COG0758	DNA mediated transformation
HCU35_RS19610	COG0242	peptide deformylase activity
HCU35_RS19615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCU35_RS19620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HCU35_RS19620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCU35_RS19630	COG1970	mechanosensitive ion channel activity
HCU35_RS19635	COG3036	rescue of stalled ribosome
HCU35_RS19640	COG0789	Transcriptional regulator
HCU35_RS19655	COG0202	RNA polymerase activity
HCU35_RS19665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HCU35_RS19680	COG0201	protein transport
HCU35_RS19690	COG1841	ribosomal large subunit assembly
HCU35_RS19705	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HCU35_RS19710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HCU35_RS19740	COG0255	Belongs to the universal ribosomal protein uL29 family
HCU35_RS19745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HCU35_RS19785	COG0051	transcription antitermination factor activity, RNA binding
HCU35_RS19825	COG2168	tRNA wobble position uridine thiolation
HCU35_RS19830	COG2923	Belongs to the DsrF TusC family
HCU35_RS19835	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HCU35_RS19840	COG2964	Protein conserved in bacteria
HCU35_RS19845	COG0545	Peptidyl-prolyl cis-trans isomerase
HCU35_RS19855	COG1047	Peptidyl-prolyl cis-trans
HCU35_RS19860	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HCU35_RS19865	COG0475	glutathione-regulated potassium exporter activity
HCU35_RS19865	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCU35_RS19870	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCU35_RS19875	COG0488	(ABC) transporter
HCU35_RS19885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCU35_RS19895	COG0679	Auxin Efflux Carrier
HCU35_RS19925	COG0429	hydrolase of the alpha beta-hydrolase fold
HCU35_RS19930	COG3089	Belongs to the UPF0270 family
HCU35_RS19935	COG3954	Phosphoribulokinase
HCU35_RS19940	COG1765	OsmC-like protein
HCU35_RS19950	COG1289	transmembrane transporter activity
HCU35_RS19955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCU35_RS19965	COG2184	nucleotidyltransferase activity
HCU35_RS19975	COG0738	Major facilitator superfamily
HCU35_RS19980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCU35_RS19990	COG1648	precorrin-2 dehydrogenase activity
HCU35_RS19990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCU35_RS20000	COG0180	Tryptophanyl-tRNA synthetase
HCU35_RS20010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCU35_RS20015	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HCU35_RS20020	COG3266	domain, Protein
HCU35_RS20025	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HCU35_RS20030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCU35_RS20035	COG4796	Type ii and iii secretion system protein
HCU35_RS20055	COG4972	Pilus assembly protein
HCU35_RS20060	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HCU35_RS20065	COG0494	nUDIX hydrolase
HCU35_RS20075	COG1011	Hydrolase
HCU35_RS20080	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HCU35_RS20085	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HCU35_RS20090	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HCU35_RS20105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCU35_RS20110	COG2183	response to ionizing radiation
HCU35_RS20115	COG1918	ferrous iron import across plasma membrane
HCU35_RS20135	COG1040	competence protein
HCU35_RS20145	COG2610	gluconate transmembrane transporter activity
HCU35_RS20150	COG1640	4-alpha-glucanotransferase
HCU35_RS20155	COG0058	SHG alpha-glucan phosphorylase activity
HCU35_RS20160	COG2909	trisaccharide binding
HCU35_RS20165	COG1349	DNA-binding transcription factor activity
HCU35_RS20170	COG0705	Rhomboid family
HCU35_RS20175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCU35_RS20180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCU35_RS20185	COG0058	SHG alpha-glucan phosphorylase activity
HCU35_RS20190	COG0297	glycogen (starch) synthase activity
HCU35_RS20195	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCU35_RS20200	COG1523	belongs to the glycosyl hydrolase 13 family
HCU35_RS20205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCU35_RS20210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCU35_RS20215	COG2095	MarC family integral membrane protein
HCU35_RS20230	COG2610	gluconate transmembrane transporter activity
HCU35_RS20235	COG3265	gluconokinase activity
HCU35_RS20240	COG1609	Transcriptional regulator
HCU35_RS20245	COG1741	Belongs to the pirin family
HCU35_RS20250	COG0673	inositol 2-dehydrogenase activity
HCU35_RS20255	COG1247	-acetyltransferase
HCU35_RS20260	COG0405	Gamma-glutamyltransferase
HCU35_RS20270	COG0584	glycerophosphoryl diester phosphodiesterase
HCU35_RS20300	COG0411	ABC transporter
HCU35_RS20305	COG4177	L-phenylalanine transmembrane transporter activity
HCU35_RS20315	COG0683	leucine binding
HCU35_RS20320	COG0456	acetyltransferase
HCU35_RS20325	COG0683	leucine binding
HCU35_RS20330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCU35_RS20335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCU35_RS20340	COG2177	Part of the ABC transporter FtsEX involved in
HCU35_RS20345	COG2884	Cell division ATP-binding protein ftsE
HCU35_RS20350	COG0552	protein localization to endoplasmic reticulum
HCU35_RS20355	COG0742	ribosomal rna small subunit methyltransferase
HCU35_RS20360	COG3776	membrane
HCU35_RS20370	COG3714	YhhN family
HCU35_RS20375	COG2217	Heavy metal translocating P-type atpase
HCU35_RS20390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HCU35_RS20395	COG0425	Belongs to the sulfur carrier protein TusA family
HCU35_RS20400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HCU35_RS20410	COG0628	permease
HCU35_RS20430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCU35_RS20450	COG1216	Glycosyl transferase, family 2
HCU35_RS20475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCU35_RS20485	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS20490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCU35_RS20535	COG3479	Phenolic acid decarboxylase
HCU35_RS20540	COG0583	DNA-binding transcription factor activity
HCU35_RS20545	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS20565	COG2205	protein histidine kinase activity
HCU35_RS20570	COG0745	RESPONSE REGULATOR receiver
HCU35_RS20575	COG1276	copper resistance
HCU35_RS20580	COG2372	response to copper ion
HCU35_RS20585	COG3667	copper resistance
HCU35_RS20590	COG2132	Multicopper oxidase
HCU35_RS20600	COG0739	heme binding
HCU35_RS20630	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCU35_RS20695	COG2081	HI0933 family
HCU35_RS20700	COG0306	phosphate transporter
HCU35_RS20710	COG0589	response to stress
HCU35_RS20715	COG0742	ribosomal rna small subunit methyltransferase
HCU35_RS20720	COG0339	signal peptide processing
HCU35_RS20725	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HCU35_RS20730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCU35_RS20750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCU35_RS20760	COG2197	response regulator
HCU35_RS20765	COG1028	Short-chain dehydrogenase reductase Sdr
HCU35_RS20770	COG0583	DNA-binding transcription factor activity
HCU35_RS20775	COG1295	ribonuclease BN
HCU35_RS20780	COG0477	Major facilitator Superfamily
HCU35_RS20785	COG2982	Protein involved in outer membrane biogenesis
HCU35_RS20790	COG2200	EAL domain
HCU35_RS20800	COG0612	Peptidase, M16
HCU35_RS20805	COG1301	dicarboxylic acid transport
HCU35_RS20810	COG2199	diguanylate cyclase activity
HCU35_RS20810	COG2200	EAL domain
HCU35_RS20815	COG0457	Tetratricopeptide repeat
HCU35_RS20815	COG3118	belongs to the thioredoxin family
HCU35_RS20820	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HCU35_RS20825	COG1215	transferase activity, transferring glycosyl groups
HCU35_RS20855	COG2194	sulfuric ester hydrolase activity
HCU35_RS20865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCU35_RS20895	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HCU35_RS20905	COG1739	Uncharacterized protein family UPF0029
HCU35_RS20910	COG0006	proline dipeptidase activity
HCU35_RS20915	COG1024	Enoyl-CoA hydratase
HCU35_RS20915	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCU35_RS20920	COG0183	Belongs to the thiolase family
HCU35_RS20925	COG0751	glycine-tRNA ligase activity
HCU35_RS20930	COG0752	glycyl-tRNA synthetase alpha subunit
HCU35_RS20940	COG3274	enterobacterial common antigen metabolic process
HCU35_RS20945	COG1070	Carbohydrate kinase
HCU35_RS20950	COG2115	Belongs to the xylose isomerase family
HCU35_RS20955	COG4213	ABC transporter substrate-binding protein
HCU35_RS20965	COG4214	carbohydrate transport
HCU35_RS20970	COG2207	Transcriptional regulator
HCU35_RS20970	COG1609	Transcriptional regulator
HCU35_RS20975	COG2992	FlgJ-related protein
HCU35_RS20980	COG0366	Alpha amylase catalytic
HCU35_RS20985	COG3977	Valine--pyruvate aminotransferase
HCU35_RS20990	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCU35_RS20995	COG1414	Transcriptional regulator
HCU35_RS21005	COG2731	YhcH YjgK YiaL family protein
HCU35_RS21015	COG2271	Major facilitator Superfamily
HCU35_RS21020	COG1070	Carbohydrate kinase
HCU35_RS21025	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HCU35_RS21030	COG3623	hexulose-6-phosphate isomerase
HCU35_RS21035	COG0235	Class ii aldolase
HCU35_RS21065	COG1012	belongs to the aldehyde dehydrogenase family
HCU35_RS21070	COG1940	carbohydrate kinase activity
HCU35_RS21075	COG3276	selenocysteine insertion sequence binding
HCU35_RS21085	COG0625	glutathione transferase activity
HCU35_RS21090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS21090	COG2213	PTS system mannitol-specific
HCU35_RS21100	COG3722	fumarate hydratase activity
HCU35_RS21120	COG3121	Chaperone
HCU35_RS21125	COG3539	Fimbrial protein
HCU35_RS21135	COG2186	Transcriptional regulator
HCU35_RS21140	COG1304	FMN binding
HCU35_RS21145	COG2271	Major facilitator Superfamily
HCU35_RS21150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HCU35_RS21160	COG0583	DNA-binding transcription factor activity
HCU35_RS21165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCU35_RS21175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCU35_RS21180	COG3978	acetolactate synthase activity
HCU35_RS21205	COG3085	chromosome segregation
HCU35_RS21255	COG4206	TonB-dependent receptor
HCU35_RS21260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCU35_RS21280	COG0583	DNA-binding transcription factor activity
HCU35_RS21285	COG0165	Argininosuccinate lyase
HCU35_RS21295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HCU35_RS21300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCU35_RS21305	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HCU35_RS21310	COG0371	Dehydrogenase
HCU35_RS21315	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HCU35_RS21325	COG0460	homoserine dehydrogenase
HCU35_RS21325	COG0527	aspartate kinase activity
HCU35_RS21330	COG0626	cystathionine gamma-synthase activity
HCU35_RS21340	COG0254	rRNA binding
HCU35_RS21345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCU35_RS21350	COG1609	Transcriptional regulator
HCU35_RS21355	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCU35_RS21370	COG1575	Belongs to the MenA family. Type 1 subfamily
HCU35_RS21380	COG3074	FtsZ-dependent cytokinesis
HCU35_RS21385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HCU35_RS21395	COG1494	fructose-1,6-bisphosphatase
HCU35_RS21405	COG3152	Membrane
HCU35_RS21415	COG0149	triose-phosphate isomerase activity
HCU35_RS21425	COG2134	cdp-diacylglycerol pyrophosphatase
HCU35_RS21435	COG0205	6-phosphofructokinase activity
HCU35_RS21445	COG3678	ATP-independent chaperone mediated protein folding
HCU35_RS21450	COG0745	RESPONSE REGULATOR receiver
HCU35_RS21455	COG2205	protein histidine kinase activity
HCU35_RS21460	COG2258	MOSC domain
HCU35_RS21465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCU35_RS21475	COG4977	sequence-specific DNA binding
HCU35_RS21475	COG1917	Cupin 2, conserved barrel domain protein
HCU35_RS21480	COG4977	sequence-specific DNA binding
HCU35_RS21485	COG1070	Carbohydrate kinase
HCU35_RS21490	COG4806	L-rhamnose isomerase
HCU35_RS21495	COG0235	Class ii aldolase
HCU35_RS21505	COG1129	ABC transporter
HCU35_RS21510	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCU35_RS21520	COG1454	alcohol dehydrogenase
HCU35_RS21530	COG2211	Major facilitator Superfamily
HCU35_RS21550	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HCU35_RS21560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS21565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU35_RS21565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCU35_RS21570	COG1363	Peptidase, m42
HCU35_RS21575	COG3711	transcriptional antiterminator
HCU35_RS21575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCU35_RS21585	COG3188	usher protein
HCU35_RS21590	COG3121	Chaperone
HCU35_RS21615	COG0437	4 iron, 4 sulfur cluster binding
HCU35_RS21620	COG2864	formate dehydrogenase
HCU35_RS21625	COG3058	Necessary for formate dehydrogenase activity
HCU35_RS21635	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HCU35_RS21645	COG0456	acetyltransferase
HCU35_RS21660	COG1011	Hydrolase
HCU35_RS21665	COG1349	DNA-binding transcription factor activity
HCU35_RS21670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCU35_RS21680	COG3684	Belongs to the aldolase LacD family
HCU35_RS21690	COG1501	Belongs to the glycosyl hydrolase 31 family
HCU35_RS21705	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HCU35_RS21720	COG3852	Histidine kinase
HCU35_RS21735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCU35_RS21740	COG3078	GTPase activator activity
HCU35_RS21755	COG0204	Acyl-transferase
HCU35_RS21765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCU35_RS21770	COG3084	Protein conserved in bacteria
HCU35_RS21775	COG0746	molybdenum cofactor guanylyltransferase activity
HCU35_RS21780	COG1763	Mo-molybdopterin cofactor biosynthetic process
HCU35_RS21805	COG2186	Transcriptional regulator
HCU35_RS21810	COG0477	Major facilitator Superfamily
HCU35_RS21815	COG1609	Transcriptional regulator
HCU35_RS21820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCU35_RS21830	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCU35_RS21835	COG1129	ABC transporter
HCU35_RS21840	COG1869	D-ribose catabolic process
HCU35_RS21845	COG3158	transport of potassium into the cell
HCU35_RS21855	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HCU35_RS21860	COG2502	aspartate--ammonia ligase
HCU35_RS21865	COG1522	sequence-specific DNA binding
HCU35_RS21870	COG0716	FMN binding
HCU35_RS21880	COG0357	Ribosomal RNA small subunit methyltransferase G
HCU35_RS21885	COG3312	ion transport
HCU35_RS21890	COG0356	it plays a direct role in the translocation of protons across the membrane
HCU35_RS21900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HCU35_RS21905	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCU35_RS21920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HCU35_RS21925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HCU35_RS21930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCU35_RS21940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCU35_RS21945	COG0573	inorganic phosphate transmembrane transporter activity
HCU35_RS21950	COG0581	inorganic phosphate transmembrane transporter activity
HCU35_RS21955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCU35_RS21960	COG0704	Plays a role in the regulation of phosphate uptake
HCU35_RS21965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCU35_RS21970	COG2252	PERMEase
HCU35_RS21975	COG0431	NADPH-dependent FMN reductase
HCU35_RS21980	COG2091	lysine biosynthetic process via aminoadipic acid
HCU35_RS22000	COG0706	membrane insertase activity
HCU35_RS22080	COG1192	Involved in chromosome partitioning
HCU35_RS22170	COG0210	DNA helicase
HCU35_RS22310	COG4245	von Willebrand factor, type A
HCU35_RS22315	COG4245	von Willebrand factor, type A
HCU35_RS22345	COG1358	cellular component organization or biogenesis
HCU35_RS22460	COG3550	peptidyl-serine autophosphorylation
HCU35_RS22485	COG0789	Transcriptional regulator
HCU35_RS22535	COG0789	Transcriptional regulator
HCU35_RS22795	COG2801	Transposase and inactivated derivatives
HCU35_RS22800	COG3547	Transposase (IS116 IS110 IS902 family)
HCU35_RS22810	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HCU35_RS22815	COG3077	Addiction module antitoxin, RelB DinJ family
HCU35_RS22820	COG2026	Addiction module toxin, RelE StbE family
HCU35_RS22975	COG3157	Type VI secretion system effector, Hcp
HCU35_RS22990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCU35_RS23010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCU35_RS23010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCU35_RS23030	COG3039	Transposase
HCU35_RS23060	COG2801	Transposase and inactivated derivatives
HCU35_RS23065	COG0431	NADPH-dependent FMN reductase
HCU35_RS23070	COG0640	Transcriptional regulator
HCU35_RS23075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCU35_RS23080	COG1393	Belongs to the ArsC family
HCU35_RS23085	COG0589	response to stress
HCU35_RS23090	COG0659	secondary active sulfate transmembrane transporter activity
HCU35_RS23170	COG2205	protein histidine kinase activity
HCU35_RS23180	COG2194	sulfuric ester hydrolase activity
HCU35_RS23230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCU35_RS23295	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCU35_RS23320	COG1349	DNA-binding transcription factor activity
HCU35_RS23325	COG2084	Dehydrogenase
HCU35_RS23475	COG2890	protein-(glutamine-N5) methyltransferase activity
HCU35_RS23535	COG0338	D12 class N6 adenine-specific DNA methyltransferase