locus-tag	class	description
HV033_RS00010	COG0592	DNA-directed DNA polymerase activity
HV033_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HV033_RS00035	COG0583	DNA-binding transcription factor activity
HV033_RS00045	COG0561	phosphatase activity
HV033_RS00050	COG2186	Transcriptional regulator
HV033_RS00055	COG3734	2-keto-3-deoxy-galactonokinase
HV033_RS00060	COG0800	Aldolase
HV033_RS00065	COG4948	Mandelate Racemase Muconate Lactonizing
HV033_RS00070	COG2271	Major facilitator Superfamily
HV033_RS00075	COG0823	Involved in the tonB-independent uptake of proteins
HV033_RS00080	COG5645	(Lipo)protein
HV033_RS00090	COG0071	Belongs to the small heat shock protein (HSP20) family
HV033_RS00095	COG2985	domain, Protein
HV033_RS00100	COG2188	Transcriptional regulator
HV033_RS00115	COG2149	membrane
HV033_RS00135	COG2814	Major facilitator Superfamily
HV033_RS00160	COG5499	transcription regulator containing HTH domain
HV033_RS00170	COG0028	Belongs to the TPP enzyme family
HV033_RS00175	COG0440	acetolactate synthase activity
HV033_RS00180	COG2197	response regulator
HV033_RS00200	COG0596	Alpha beta hydrolase
HV033_RS00215	COG0697	spore germination
HV033_RS00220	COG4580	involved in the transport of maltose and maltodextrins
HV033_RS00225	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV033_RS00230	COG2723	6-phospho-beta-galactosidase activity
HV033_RS00235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV033_RS00235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV033_RS00245	COG1609	Transcriptional regulator
HV033_RS00260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV033_RS00265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV033_RS00275	COG0454	-acetyltransferase
HV033_RS00280	COG1309	transcriptional regulator
HV033_RS00290	COG1464	Belongs to the NlpA lipoprotein family
HV033_RS00315	COG3188	usher protein
HV033_RS00320	COG3121	Chaperone
HV033_RS00350	COG3188	usher protein
HV033_RS00375	COG2274	protein secretion by the type I secretion system
HV033_RS00390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HV033_RS00395	COG4977	sequence-specific DNA binding
HV033_RS00415	COG3272	Protein of unknown function (DUF1722)
HV033_RS00420	COG2351	hydroxyisourate hydrolase activity
HV033_RS00425	COG0789	Transcriptional regulator
HV033_RS00450	COG3121	Chaperone
HV033_RS00505	COG2211	Major facilitator Superfamily
HV033_RS00510	COG1501	Belongs to the glycosyl hydrolase 31 family
HV033_RS00515	COG2982	Protein involved in outer membrane biogenesis
HV033_RS00520	COG2233	PERMEase
HV033_RS00525	COG0786	glutamate:sodium symporter activity
HV033_RS00530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV033_RS00535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV033_RS00540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV033_RS00555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HV033_RS00560	COG2860	membrane
HV033_RS00565	COG1561	YicC-like family, N-terminal region
HV033_RS00575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HV033_RS00585	COG0756	dUTP diphosphatase activity
HV033_RS00590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV033_RS00595	COG2003	Belongs to the UPF0758 family
HV033_RS00600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HV033_RS00605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV033_RS00610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HV033_RS00615	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HV033_RS00625	COG1519	Transferase
HV033_RS00630	COG1216	Glycosyl transferase, family 2
HV033_RS00635	COG0438	transferase activity, transferring glycosyl groups
HV033_RS00645	COG0859	PFAM glycosyl transferase family 9
HV033_RS00670	COG0859	PFAM glycosyl transferase family 9
HV033_RS00675	COG0859	PFAM glycosyl transferase family 9
HV033_RS00690	COG1063	alcohol dehydrogenase
HV033_RS00705	COG0463	Glycosyl transferase, family 2
HV033_RS00710	COG2861	carbohydrate metabolic process
HV033_RS00715	COG4942	peptidase
HV033_RS00720	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HV033_RS00725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV033_RS00730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV033_RS00735	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HV033_RS00740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HV033_RS00750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV033_RS00760	COG0248	Ppx GppA phosphatase
HV033_RS00770	COG3118	belongs to the thioredoxin family
HV033_RS00775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV033_RS00780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV033_RS00790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HV033_RS00795	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV033_RS00800	COG0456	acetyltransferase
HV033_RS00805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV033_RS00810	COG2244	polysaccharide biosynthetic process
HV033_RS00825	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HV033_RS00855	COG3071	HemY protein
HV033_RS00860	COG2959	enzyme of heme biosynthesis
HV033_RS00870	COG0181	hydroxymethylbilane synthase activity
HV033_RS00905	COG1011	Hydrolase
HV033_RS00910	COG0210	DNA helicase
HV033_RS00930	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HV033_RS00940	COG1280	lysine exporter protein (LysE YggA)
HV033_RS00945	COG1280	lysine exporter protein (LysE YggA)
HV033_RS00950	COG2267	carboxylic ester hydrolase activity
HV033_RS00955	COG0561	phosphatase activity
HV033_RS00960	COG0697	spore germination
HV033_RS00965	COG0583	DNA-binding transcription factor activity
HV033_RS00975	COG0412	Dienelactone hydrolase
HV033_RS00985	COG1322	Protein conserved in bacteria
HV033_RS00990	COG2226	methyltransferase
HV033_RS00995	COG3165	ubiquinone biosynthetic process from chorismate
HV033_RS01000	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HV033_RS01010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HV033_RS01015	COG0805	protein transport
HV033_RS01020	COG0084	hydrolase, TatD family'
HV033_RS01030	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV033_RS01040	COG0488	(ABC) transporter
HV033_RS01045	COG2944	sequence-specific DNA binding
HV033_RS01055	COG1278	Cold shock
HV033_RS01060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV033_RS01070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV033_RS01080	COG1609	Transcriptional regulator
HV033_RS01085	COG2885	chlorophyll binding
HV033_RS01090	COG0243	molybdopterin cofactor binding
HV033_RS01095	COG0456	acetyltransferase
HV033_RS01100	COG2818	Glycosylase
HV033_RS01105	COG5571	outer membrane autotransporter
HV033_RS01110	COG2223	nitrite transmembrane transporter activity
HV033_RS01125	COG0747	negative chemotaxis
HV033_RS01130	COG0601	transmembrane transport
HV033_RS01135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV033_RS01140	COG0444	Belongs to the ABC transporter superfamily
HV033_RS01145	COG4608	Belongs to the ABC transporter superfamily
HV033_RS01150	COG1072	(Pantothenic acid kinase))
HV033_RS01185	COG0250	Participates in transcription elongation, termination and antitermination
HV033_RS01230	COG3706	GGDEF domain
HV033_RS01240	COG2022	thiamine diphosphate biosynthetic process
HV033_RS01245	COG2104	thiamine diphosphate biosynthetic process
HV033_RS01250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV033_RS01265	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HV033_RS01275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HV033_RS01280	COG1515	deoxyribonuclease V activity
HV033_RS01285	COG3068	Protein conserved in bacteria
HV033_RS01300	COG0151	Belongs to the GarS family
HV033_RS01330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV033_RS01340	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HV033_RS01370	COG1187	pseudouridine synthase activity
HV033_RS01385	COG0527	aspartate kinase activity
HV033_RS01410	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV033_RS01415	COG3223	Belongs to the PsiE family
HV033_RS01450	COG3161	chorismate lyase activity
HV033_RS01460	COG2937	Belongs to the GPAT DAPAT family
HV033_RS01465	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV033_RS01470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV033_RS01475	COG0534	Mate efflux family protein
HV033_RS01480	COG3237	CsbD-like
HV033_RS01485	COG0735	belongs to the Fur family
HV033_RS01500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV033_RS01510	COG0604	alcohol dehydrogenase
HV033_RS01515	COG0305	Participates in initiation and elongation during chromosome replication
HV033_RS01530	COG1056	cytidyltransferase-related domain
HV033_RS01530	COG3172	ATPase kinase involved in NAD metabolism
HV033_RS01535	COG1448	Aminotransferase
HV033_RS01540	COG3700	Belongs to the class B bacterial acid phosphatase family
HV033_RS01550	COG2315	Protein conserved in bacteria
HV033_RS01560	COG0629	single-stranded DNA binding
HV033_RS01625	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HV033_RS01665	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV033_RS01675	COG0789	Transcriptional regulator
HV033_RS01680	COG0625	glutathione transferase activity
HV033_RS01685	COG2252	PERMEase
HV033_RS01690	COG0025	NhaP-type Na H and K H
HV033_RS01695	COG0583	DNA-binding transcription factor activity
HV033_RS01705	COG1346	cytolysis
HV033_RS01710	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV033_RS01715	COG3162	membrane
HV033_RS01725	COG1301	dicarboxylic acid transport
HV033_RS01730	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV033_RS01750	COG0745	RESPONSE REGULATOR receiver
HV033_RS01760	COG0191	fructose-bisphosphate aldolase activity
HV033_RS01775	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV033_RS01780	COG1129	ABC transporter
HV033_RS01785	COG4191	Histidine kinase
HV033_RS01785	COG0784	Response regulator, receiver
HV033_RS01795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV033_RS01800	COG0456	acetyltransferase
HV033_RS01805	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HV033_RS01810	COG3454	Phosphonate metabolism
HV033_RS01815	COG4778	phosphonate C-P lyase system protein PhnL
HV033_RS01820	COG4107	phosphonate C-P lyase system protein PhnK
HV033_RS01825	COG3627	carbon phosphorus lyase activity
HV033_RS01830	COG3626	phosphonate metabolism
HV033_RS01835	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV033_RS01840	COG3624	Phosphonate C-P lyase system protein PhnG
HV033_RS01845	COG2188	Transcriptional regulator
HV033_RS01850	COG3639	organic phosphonate transmembrane transporter activity
HV033_RS01855	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV033_RS01865	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV033_RS01870	COG2824	Alkylphosphonate utilization operon protein PhnA
HV033_RS01875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HV033_RS01895	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV033_RS01975	COG0582	viral genome integration into host DNA
HV033_RS01995	COG1309	transcriptional regulator
HV033_RS02010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV033_RS02015	COG1027	Aspartate ammonia-lyase
HV033_RS02020	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV033_RS02025	COG0531	amino acid
HV033_RS02035	COG0459	protein refolding
HV033_RS02040	COG0700	Nucleoside recognition
HV033_RS02045	COG3366	ferrous iron transmembrane transporter activity
HV033_RS02070	COG5510	response to toxic substance
HV033_RS02095	COG0583	DNA-binding transcription factor activity
HV033_RS02105	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HV033_RS02110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV033_RS02115	COG1053	succinate dehydrogenase
HV033_RS02120	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HV033_RS02130	COG1511	domain protein
HV033_RS02130	COG3264	Mechanosensitive ion channel
HV033_RS02165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV033_RS02170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV033_RS02170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV033_RS02175	COG0802	atpase or kinase
HV033_RS02185	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HV033_RS02190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HV033_RS02195	COG1923	regulation of RNA biosynthetic process
HV033_RS02200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV033_RS02205	COG0330	HflC and HflK could
HV033_RS02210	COG0330	HflC and HflK could
HV033_RS02215	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV033_RS02225	COG1959	2 iron, 2 sulfur cluster binding
HV033_RS02230	COG0557	exoribonuclease II activity
HV033_RS02235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV033_RS02240	COG0477	Major facilitator Superfamily
HV033_RS02245	COG1960	acyl-CoA dehydrogenase activity
HV033_RS02260	COG3650	response to hydrogen peroxide
HV033_RS02265	COG1073	alpha beta
HV033_RS02280	COG3037	sugar-specific permease SgaT UlaA
HV033_RS02320	COG2965	DNA replication, synthesis of RNA primer
HV033_RS02325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV033_RS02330	COG0359	binds to the 23S rRNA
HV033_RS02335	COG0697	spore germination
HV033_RS02340	COG3061	Opacity-associated protein A
HV033_RS02345	COG0545	Peptidyl-prolyl cis-trans isomerase
HV033_RS02350	COG1113	amino acid transport
HV033_RS02360	COG0840	transmembrane signaling receptor activity
HV033_RS02365	COG0697	spore germination
HV033_RS02375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV033_RS02375	COG2205	protein histidine kinase activity
HV033_RS02385	COG2197	response regulator
HV033_RS02405	COG0702	epimerase
HV033_RS02410	COG1733	regulation of RNA biosynthetic process
HV033_RS02420	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV033_RS02425	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV033_RS02435	COG1253	flavin adenine dinucleotide binding
HV033_RS02440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HV033_RS02445	COG0729	surface antigen
HV033_RS02450	COG2911	Protein conserved in bacteria
HV033_RS02455	COG2105	PFAM AIG2 family protein
HV033_RS02475	COG1879	ABC-type sugar transport system periplasmic component
HV033_RS02480	COG1129	ABC transporter
HV033_RS02485	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV033_RS02490	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV033_RS02505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV033_RS02510	COG3028	Belongs to the UPF0307 family
HV033_RS02515	COG0312	modulator of DNA gyrase
HV033_RS02550	COG3964	amidohydrolase
HV033_RS02570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV033_RS02570	COG3711	transcriptional antiterminator
HV033_RS02575	COG0602	queuosine metabolic process
HV033_RS02585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV033_RS02585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV033_RS02585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV033_RS02590	COG0383	alpha-mannosidase activity
HV033_RS02610	COG0366	Alpha amylase catalytic
HV033_RS02615	COG1263	PTS System
HV033_RS02615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV033_RS02620	COG1609	Transcriptional regulator
HV033_RS02630	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HV033_RS02635	COG3397	chitin binding
HV033_RS02640	COG0251	oxidation-reduction process
HV033_RS02650	COG0540	Belongs to the ATCase OTCase family
HV033_RS02665	COG1438	arginine binding
HV033_RS02670	COG1288	antiporter activity
HV033_RS02685	COG2235	arginine
HV033_RS02690	COG2731	YhcH YjgK YiaL family protein
HV033_RS02695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV033_RS02700	COG0129	dihydroxy-acid dehydratase activity
HV033_RS02705	COG2211	Major facilitator Superfamily
HV033_RS02710	COG3507	Belongs to the glycosyl hydrolase 43 family
HV033_RS02715	COG1414	Transcriptional regulator
HV033_RS02720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV033_RS02765	COG0514	ATP-dependent DNA helicase (RecQ)
HV033_RS02840	COG0582	viral genome integration into host DNA
HV033_RS02860	COG4974	Belongs to the 'phage' integrase family
HV033_RS02955	COG3328	transposase activity
HV033_RS02975	COG1609	Transcriptional regulator
HV033_RS02985	COG2211	Major facilitator Superfamily
HV033_RS03010	COG1335	isochorismatase
HV033_RS03025	COG2204	response regulator
HV033_RS03030	COG4191	Histidine kinase
HV033_RS03035	COG4566	intracellular signal transduction
HV033_RS03040	COG0740	serine-type endopeptidase activity
HV033_RS03045	COG2850	peptidyl-arginine hydroxylation
HV033_RS03070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV033_RS03075	COG5457	Domain of unknown function (DUF1127)
HV033_RS03085	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV033_RS03100	COG0640	Transcriptional regulator
HV033_RS03120	COG2733	membrane
HV033_RS03130	COG2207	Transcriptional regulator
HV033_RS03130	COG1917	Cupin 2, conserved barrel domain protein
HV033_RS03135	COG1012	belongs to the aldehyde dehydrogenase family
HV033_RS03155	COG0523	cobalamin synthesis protein
HV033_RS03160	COG2879	small protein
HV033_RS03165	COG1966	Carbon starvation protein
HV033_RS03170	COG1349	DNA-binding transcription factor activity
HV033_RS03175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV033_RS03180	COG2368	4-hydroxyphenylacetate
HV033_RS03200	COG3971	2-oxopent-4-enoate hydratase activity
HV033_RS03210	COG3384	dioxygenase
HV033_RS03215	COG1012	belongs to the aldehyde dehydrogenase family
HV033_RS03220	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV033_RS03225	COG1846	Transcriptional regulator
HV033_RS03230	COG0840	transmembrane signaling receptor activity
HV033_RS03250	COG1484	DNA-dependent DNA replication
HV033_RS03260	COG1764	response to oxidative stress
HV033_RS03265	COG1846	Transcriptional regulator
HV033_RS03270	COG3610	response to peptide
HV033_RS03275	COG2966	Psort location CytoplasmicMembrane, score
HV033_RS03280	COG2197	response regulator
HV033_RS03285	COG2197	response regulator
HV033_RS03290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV033_RS03295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV033_RS03300	COG4114	ferric iron reductase
HV033_RS03305	COG3706	GGDEF domain
HV033_RS03330	COG2813	Specifically methylates the guanine in position
HV033_RS03335	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV033_RS03340	COG0456	acetyltransferase
HV033_RS03345	COG1011	Hydrolase
HV033_RS03350	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HV033_RS03355	COG2823	Periplasmic or secreted lipoprotein
HV033_RS03360	COG5487	UPF0391 membrane protein
HV033_RS03365	COG4667	esterase of the alpha-beta hydrolase superfamily
HV033_RS03370	COG0084	hydrolase, TatD family'
HV033_RS03375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV033_RS03380	COG1328	CTP reductase activity
HV033_RS03390	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HV033_RS03410	COG3726	membrane protein affecting hemolysin expression
HV033_RS03415	COG0560	Phosphoserine phosphatase
HV033_RS03440	COG0488	(ABC) transporter
HV033_RS03445	COG0741	lytic transglycosylase activity
HV033_RS03450	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HV033_RS03455	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HV033_RS03460	COG0406	alpha-ribazole phosphatase activity
HV033_RS03465	COG3708	Transcriptional regulator
HV033_RS03465	COG2207	Transcriptional regulator
HV033_RS03470	COG3045	CreA protein
HV033_RS03475	COG0745	RESPONSE REGULATOR receiver
HV033_RS03485	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV033_RS03495	COG0527	aspartate kinase activity
HV033_RS03495	COG0460	homoserine dehydrogenase
HV033_RS03505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV033_RS03520	COG1115	amino acid carrier protein
HV033_RS03530	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV033_RS03535	COG0477	Major facilitator Superfamily
HV033_RS03540	COG1584	GPR1 FUN34 yaaH family protein
HV033_RS03545	COG0443	Heat shock 70 kDa protein
HV033_RS03555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV033_RS03560	COG0583	DNA-binding transcription factor activity
HV033_RS03565	COG0268	Binds directly to 16S ribosomal RNA
HV033_RS03570	COG0196	riboflavin kinase activity
HV033_RS03585	COG1047	Peptidyl-prolyl cis-trans
HV033_RS03590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HV033_RS03600	COG0505	Belongs to the CarA family
HV033_RS03625	COG0475	glutathione-regulated potassium exporter activity
HV033_RS03625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV033_RS03635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HV033_RS03640	COG2967	ApaG domain
HV033_RS03650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HV033_RS03655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV033_RS03660	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV033_RS03665	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV033_RS03670	COG0564	pseudouridine synthase activity
HV033_RS03675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HV033_RS03680	COG0417	DNA replication proofreading
HV033_RS03685	COG0235	Class ii aldolase
HV033_RS03690	COG2160	L-arabinose isomerase activity
HV033_RS03695	COG1069	ribulokinase activity
HV033_RS03705	COG0586	Pfam SNARE associated Golgi protein
HV033_RS03715	COG1178	ABC-type Fe3 transport system permease component
HV033_RS03735	COG2814	Major facilitator Superfamily
HV033_RS03760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HV033_RS03775	COG3039	Transposase
HV033_RS03810	COG2826	transposase and inactivated derivatives, IS30 family
HV033_RS03840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV033_RS03890	COG3039	Transposase
HV033_RS03895	COG4680	protein conserved in bacteria
HV033_RS03900	COG5499	transcription regulator containing HTH domain
HV033_RS03920	COG3436	PFAM IS66 Orf2 family protein
HV033_RS03925	COG4372	Transposase
HV033_RS03940	COG3039	Transposase
HV033_RS03960	COG0438	transferase activity, transferring glycosyl groups
HV033_RS03985	COG2244	polysaccharide biosynthetic process
HV033_RS03995	COG1091	dTDP-4-dehydrorhamnose reductase activity
HV033_RS04015	COG0438	transferase activity, transferring glycosyl groups
HV033_RS04180	COG3609	addiction module antidote protein, CC2985 family
HV033_RS04205	COG0653	protein targeting
HV033_RS04230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV033_RS04235	COG3039	Transposase
HV033_RS04240	COG3121	Chaperone
HV033_RS04245	COG3188	usher protein
HV033_RS04250	COG3539	Fimbrial protein
HV033_RS04260	COG3539	Fimbrial protein
HV033_RS04270	COG0726	polysaccharide deacetylase
HV033_RS04275	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV033_RS04280	COG0842	Transport permease protein
HV033_RS04285	COG1131	(ABC) transporter
HV033_RS04290	COG0288	reversible hydration of carbon dioxide
HV033_RS04300	COG4993	Dehydrogenase
HV033_RS04315	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HV033_RS04320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HV033_RS04335	COG3064	Membrane
HV033_RS04345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV033_RS04350	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV033_RS04355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV033_RS04360	COG2186	Transcriptional regulator
HV033_RS04365	COG1113	amino acid transport
HV033_RS04370	COG2211	Major facilitator Superfamily
HV033_RS04375	COG3940	Belongs to the glycosyl hydrolase 43 family
HV033_RS04380	COG3725	Membrane protein required for beta-lactamase induction
HV033_RS04385	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV033_RS04395	COG4969	Belongs to the N-Me-Phe pilin family
HV033_RS04400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV033_RS04405	COG1459	type II secretion system
HV033_RS04410	COG0516	GMP reductase activity
HV033_RS04420	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HV033_RS04425	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HV033_RS04430	COG0494	nUDIX hydrolase
HV033_RS04435	COG0653	protein targeting
HV033_RS04445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HV033_RS04450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV033_RS04455	COG0849	cell division
HV033_RS04465	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV033_RS04480	COG0772	Belongs to the SEDS family
HV033_RS04490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV033_RS04495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV033_RS04500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV033_RS04505	COG0768	penicillin binding
HV033_RS04520	COG2001	Belongs to the MraZ family
HV033_RS04525	COG1609	Transcriptional regulator
HV033_RS04530	COG0440	acetolactate synthase activity
HV033_RS04535	COG0028	Belongs to the TPP enzyme family
HV033_RS04545	COG3039	Transposase
HV033_RS04560	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HV033_RS04565	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HV033_RS04575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV033_RS04580	COG0617	tRNA 3'-terminal CCA addition
HV033_RS04585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HV033_RS04595	COG1489	DNA binding
HV033_RS04600	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV033_RS04605	COG1643	Atp-dependent helicase
HV033_RS04610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV033_RS04615	COG4774	siderophore transport
HV033_RS04620	COG1120	ATPase activity
HV033_RS04625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV033_RS04630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV033_RS04635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HV033_RS04645	COG0316	Belongs to the HesB IscA family
HV033_RS04650	COG2860	membrane
HV033_RS04660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV033_RS04665	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HV033_RS04670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV033_RS04675	COG3835	regulator
HV033_RS04720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV033_RS04730	COG0575	Belongs to the CDS family
HV033_RS04735	COG0750	zinc metalloprotease
HV033_RS04740	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV033_RS04755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HV033_RS04760	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV033_RS04765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV033_RS04770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HV033_RS04780	COG0825	malonyl-CoA metabolic process
HV033_RS04790	COG0346	lactoylglutathione lyase activity
HV033_RS04795	COG0037	tRNA processing
HV033_RS04800	COG4568	rho-dependent transcription termination
HV033_RS04815	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV033_RS04820	COG3015	lipoprotein NlpE involved in copper resistance
HV033_RS04830	COG1720	tRNA m6t6A37 methyltransferase activity
HV033_RS04840	COG1464	Belongs to the NlpA lipoprotein family
HV033_RS04845	COG2011	ABC-type metal ion transport system permease component
HV033_RS04855	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV033_RS04895	COG0583	DNA-binding transcription factor activity
HV033_RS04900	COG2814	Major facilitator Superfamily
HV033_RS04905	COG3021	interspecies interaction between organisms
HV033_RS04910	COG2226	methyltransferase
HV033_RS04915	COG0741	lytic transglycosylase activity
HV033_RS04915	COG1388	LysM domain
HV033_RS04920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV033_RS04925	COG2226	methyltransferase
HV033_RS04950	COG0444	Belongs to the ABC transporter superfamily
HV033_RS04955	COG4608	Belongs to the ABC transporter superfamily
HV033_RS04980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV033_RS04985	COG1960	acyl-CoA dehydrogenase activity
HV033_RS04995	COG0121	glutamine amidotransferase
HV033_RS05000	COG3034	peptidoglycan biosynthetic process
HV033_RS05015	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV033_RS05020	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV033_RS05035	COG2991	Protein conserved in bacteria
HV033_RS05040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV033_RS05045	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV033_RS05065	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV033_RS05070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV033_RS05075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HV033_RS05130	COG0582	viral genome integration into host DNA
HV033_RS05170	COG0702	epimerase
HV033_RS05180	COG0667	Aldo Keto reductase
HV033_RS05185	COG0656	L-ascorbic acid biosynthetic process
HV033_RS05220	COG5002	protein histidine kinase activity
HV033_RS05230	COG0667	Aldo Keto reductase
HV033_RS05240	COG0778	Nitroreductase
HV033_RS05245	COG2814	Major facilitator Superfamily
HV033_RS05250	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV033_RS05260	COG5001	Diguanylate cyclase
HV033_RS05260	COG3300	MHYT domain
HV033_RS05280	COG0628	permease
HV033_RS05285	COG0833	amino acid
HV033_RS05290	COG2040	homocysteine
HV033_RS05295	COG4521	taurine ABC transporter
HV033_RS05300	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV033_RS05305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV033_RS05310	COG2175	clavaminate synthase activity
HV033_RS05320	COG0113	porphobilinogen synthase activity
HV033_RS05335	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV033_RS05340	COG1335	isochorismatase
HV033_RS05345	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV033_RS05365	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV033_RS05390	COG3706	GGDEF domain
HV033_RS05395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV033_RS05400	COG1671	Belongs to the UPF0178 family
HV033_RS05405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV033_RS05415	COG4126	flavin adenine dinucleotide binding
HV033_RS05420	COG3123	guanosine phosphorylase activity
HV033_RS05430	COG1940	carbohydrate kinase activity
HV033_RS05435	COG0419	ATPase involved in DNA repair
HV033_RS05440	COG0420	3'-5' exonuclease activity
HV033_RS05450	COG5002	protein histidine kinase activity
HV033_RS05465	COG0366	Alpha amylase catalytic
HV033_RS05480	COG0450	alkyl hydroperoxide reductase
HV033_RS05485	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HV033_RS05500	COG1862	Preprotein translocase
HV033_RS05505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV033_RS05510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV033_RS05525	COG4238	major outer membrane lipoprotein
HV033_RS05530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HV033_RS05535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV033_RS05535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV033_RS05540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HV033_RS05545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HV033_RS05550	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV033_RS05555	COG0667	Aldo Keto reductase
HV033_RS05560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV033_RS05565	COG0142	geranyltranstransferase activity
HV033_RS05580	COG0693	protein deglycase activity
HV033_RS05595	COG2814	Major facilitator Superfamily
HV033_RS05600	COG0235	Class ii aldolase
HV033_RS05610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV033_RS05620	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV033_RS05625	COG1129	ABC transporter
HV033_RS05645	COG0109	protoheme IX farnesyltransferase activity
HV033_RS05650	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV033_RS05655	COG1845	cytochrome c oxidase, subunit III
HV033_RS05660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV033_RS05665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV033_RS05670	COG2223	nitrite transmembrane transporter activity
HV033_RS05675	COG3056	Lipoprotein
HV033_RS05680	COG0271	Belongs to the BolA IbaG family
HV033_RS05685	COG0544	peptidyl-prolyl cis-trans isomerase activity
HV033_RS05700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV033_RS05705	COG0776	regulation of translation
HV033_RS05710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV033_RS05715	COG1555	photosystem II stabilization
HV033_RS05720	COG0824	Thioesterase
HV033_RS05725	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HV033_RS05730	COG4533	DNA binding
HV033_RS05735	COG0561	phosphatase activity
HV033_RS05745	COG1522	sequence-specific DNA binding
HV033_RS05750	COG1132	(ABC) transporter
HV033_RS05755	COG1132	(ABC) transporter
HV033_RS05760	COG0347	Belongs to the P(II) protein family
HV033_RS05765	COG0004	ammonium transporteR
HV033_RS05770	COG1946	Acyl-CoA thioesterase
HV033_RS05775	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV033_RS05780	COG3695	enzyme binding
HV033_RS05800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV033_RS05805	COG2364	Membrane
HV033_RS05810	COG1609	Transcriptional regulator
HV033_RS05820	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV033_RS05830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HV033_RS05850	COG0110	maltose O-acetyltransferase activity
HV033_RS05865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV033_RS05870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV033_RS05875	COG1309	transcriptional regulator
HV033_RS05880	COG3264	Mechanosensitive ion channel
HV033_RS05880	COG1196	nuclear chromosome segregation
HV033_RS05890	COG3923	Primosomal replication protein n
HV033_RS05895	COG2832	Protein of unknown function (DUF454)
HV033_RS05900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HV033_RS05910	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HV033_RS05915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HV033_RS05920	COG0326	Molecular chaperone. Has ATPase activity
HV033_RS05930	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HV033_RS05935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV033_RS05940	COG4651	solute:proton antiporter activity
HV033_RS05940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV033_RS05945	COG2223	nitrite transmembrane transporter activity
HV033_RS05955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV033_RS05960	COG3735	TraB family
HV033_RS05965	COG2217	Heavy metal translocating P-type atpase
HV033_RS05975	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV033_RS05980	COG0330	HflC and HflK could
HV033_RS05990	COG4619	ABC transporter
HV033_RS05995	COG0390	transport system, permease component
HV033_RS06000	COG3118	belongs to the thioredoxin family
HV033_RS06005	COG0300	oxidoreductase activity
HV033_RS06010	COG2755	lipolytic protein G-D-S-L family
HV033_RS06015	COG4181	ATPase activity
HV033_RS06020	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV033_RS06025	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV033_RS06040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV033_RS06045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV033_RS06050	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV033_RS06055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV033_RS06065	COG1988	membrane-bound metal-dependent
HV033_RS06070	COG1609	Transcriptional regulator
HV033_RS06075	COG2190	(PTS) system
HV033_RS06075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV033_RS06075	COG1263	PTS System
HV033_RS06080	COG2501	S4 domain
HV033_RS06150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HV033_RS06170	COG1113	amino acid transport
HV033_RS06175	COG2211	Major facilitator Superfamily
HV033_RS06190	COG1609	Transcriptional regulator
HV033_RS06195	COG0668	transmembrane transport
HV033_RS06200	COG0477	Major facilitator Superfamily
HV033_RS06215	COG0778	Nitroreductase
HV033_RS06220	COG2315	Protein conserved in bacteria
HV033_RS06235	COG2207	Transcriptional regulator
HV033_RS06240	COG4774	siderophore transport
HV033_RS06325	COG1278	Cold shock
HV033_RS06375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV033_RS06395	COG1121	(ABC) transporter
HV033_RS06400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV033_RS06405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV033_RS06410	COG2977	Belongs to the P-Pant transferase superfamily
HV033_RS06415	COG4771	TonB-dependent receptor
HV033_RS06420	COG2382	esterase
HV033_RS06425	COG3251	PFAM MbtH domain protein
HV033_RS06430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV033_RS06430	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV033_RS06435	COG1120	ATPase activity
HV033_RS06440	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV033_RS06445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV033_RS06455	COG4592	Periplasmic binding protein
HV033_RS06460	COG1169	isochorismate synthase
HV033_RS06465	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV033_RS06470	COG3433	isochorismatase activity
HV033_RS06470	COG1535	isochorismatase
HV033_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS06480	COG2050	protein possibly involved in aromatic compounds catabolism
HV033_RS06490	COG0700	Nucleoside recognition
HV033_RS06495	COG3366	ferrous iron transmembrane transporter activity
HV033_RS06500	COG1966	Carbon starvation protein
HV033_RS06505	COG2879	small protein
HV033_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS06525	COG0371	Dehydrogenase
HV033_RS06530	COG1129	ABC transporter
HV033_RS06535	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV033_RS06550	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HV033_RS06565	COG3423	Transcriptional regulator
HV033_RS06580	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HV033_RS06585	COG0235	Class ii aldolase
HV033_RS06590	COG0436	Aminotransferase
HV033_RS06595	COG1475	DNA binding
HV033_RS06600	COG3969	phosphoadenosine phosphosulfate
HV033_RS06605	COG0583	DNA-binding transcription factor activity
HV033_RS06625	COG1063	alcohol dehydrogenase
HV033_RS06630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV033_RS06640	COG3719	Belongs to the RNase T2 family
HV033_RS06645	COG3069	C4-dicarboxylate transmembrane transporter activity
HV033_RS06665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV033_RS06690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV033_RS06695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HV033_RS06700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HV033_RS06705	COG0583	DNA-binding transcription factor activity
HV033_RS06710	COG0321	lipoyl(octanoyl) transferase activity
HV033_RS06720	COG1686	Belongs to the peptidase S11 family
HV033_RS06725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV033_RS06730	COG0772	Belongs to the SEDS family
HV033_RS06735	COG0768	penicillin binding
HV033_RS06745	COG0799	negative regulation of ribosome biogenesis
HV033_RS06755	COG1466	dna polymerase III delta subunit
HV033_RS06770	COG2888	peptidyl-tyrosine sulfation
HV033_RS06775	COG1957	nucleoside hydrolase
HV033_RS06780	COG1126	abc transporter atp-binding protein
HV033_RS06785	COG0765	amino acid transport
HV033_RS06790	COG0765	amino acid transport
HV033_RS06810	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HV033_RS06815	COG1702	phosphate starvation-inducible protein PhoH
HV033_RS06820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HV033_RS06825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV033_RS06865	COG0367	asparagine synthase
HV033_RS06870	COG0647	UMP catabolic process
HV033_RS06875	COG1846	Transcriptional regulator
HV033_RS06875	COG1940	carbohydrate kinase activity
HV033_RS06880	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV033_RS06890	COG2190	(PTS) system
HV033_RS06890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV033_RS06890	COG1263	PTS System
HV033_RS06895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HV033_RS06910	COG0735	belongs to the Fur family
HV033_RS06930	COG0596	Alpha beta hydrolase
HV033_RS06935	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV033_RS06940	COG0033	Phosphoglucomutase
HV033_RS06945	COG0531	amino acid
HV033_RS06950	COG1982	Orn Lys Arg decarboxylase major
HV033_RS06960	COG0745	RESPONSE REGULATOR receiver
HV033_RS06965	COG2205	protein histidine kinase activity
HV033_RS06970	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HV033_RS06975	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HV033_RS06980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HV033_RS07000	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HV033_RS07005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV033_RS07010	COG1984	allophanate hydrolase subunit 2
HV033_RS07020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HV033_RS07025	COG0372	Belongs to the citrate synthase family
HV033_RS07030	COG2009	succinate dehydrogenase
HV033_RS07035	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV033_RS07040	COG1053	succinate dehydrogenase
HV033_RS07045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV033_RS07050	COG0567	Dehydrogenase, E1 component
HV033_RS07055	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV033_RS07060	COG0045	succinate-CoA ligase (ADP-forming) activity
HV033_RS07065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV033_RS07070	COG2188	Transcriptional regulator
HV033_RS07075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV033_RS07075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV033_RS07075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV033_RS07080	COG0383	alpha-mannosidase activity
HV033_RS07085	COG1271	oxidase subunit
HV033_RS07090	COG1294	oxidase, subunit
HV033_RS07095	COG4890	Cyd operon protein YbgT
HV033_RS07100	COG3790	cyd operon protein YbgE
HV033_RS07105	COG0824	Thioesterase
HV033_RS07110	COG0811	peptide transport
HV033_RS07115	COG0848	biopolymer transport protein
HV033_RS07120	COG3064	Membrane
HV033_RS07125	COG0823	Involved in the tonB-independent uptake of proteins
HV033_RS07130	COG2885	chlorophyll binding
HV033_RS07135	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV033_RS07170	COG3201	nicotinamide mononucleotide transporter
HV033_RS07175	COG1230	cation diffusion facilitator family transporter
HV033_RS07185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV033_RS07195	COG2017	converts alpha-aldose to the beta-anomer
HV033_RS07200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HV033_RS07205	COG1085	galactose-1-phosphate uridylyltransferase
HV033_RS07210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV033_RS07215	COG1119	ATPase activity
HV033_RS07220	COG2005	Transcriptional regulator
HV033_RS07220	COG3585	molybdate ion transport
HV033_RS07230	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV033_RS07235	COG4149	molybdate abc transporter
HV033_RS07245	COG0561	phosphatase activity
HV033_RS07250	COG2706	6-phosphogluconolactonase activity
HV033_RS07255	COG4677	pectinesterase activity
HV033_RS07265	COG0010	Belongs to the arginase family
HV033_RS07275	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HV033_RS07280	COG2986	histidine ammonia-lyase
HV033_RS07285	COG1881	PFAM PEBP family protein
HV033_RS07290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HV033_RS07295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HV033_RS07300	COG0156	8-amino-7-oxononanoate synthase activity
HV033_RS07305	COG2226	methyltransferase
HV033_RS07335	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV033_RS07340	COG0315	cyclic pyranopterin monophosphate synthase activity
HV033_RS07345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV033_RS07350	COG0314	molybdopterin synthase activity
HV033_RS07355	COG0670	Belongs to the BI1 family
HV033_RS07360	COG0392	lysyltransferase activity
HV033_RS07365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV033_RS07370	COG3568	Endonuclease Exonuclease Phosphatase
HV033_RS07380	COG0842	Transport permease protein
HV033_RS07385	COG0842	Transport permease protein
HV033_RS07390	COG1131	(ABC) transporter
HV033_RS07395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV033_RS07400	COG1309	transcriptional regulator
HV033_RS07405	COG0513	Belongs to the DEAD box helicase family
HV033_RS07430	COG3121	Chaperone
HV033_RS07435	COG3539	Fimbrial protein
HV033_RS07440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV033_RS07450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV033_RS07460	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HV033_RS07465	COG0668	transmembrane transport
HV033_RS07470	COG1126	abc transporter atp-binding protein
HV033_RS07475	COG0765	amino acid transport
HV033_RS07480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV033_RS07485	COG0783	Belongs to the Dps family
HV033_RS07495	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV033_RS07500	COG2194	sulfuric ester hydrolase activity
HV033_RS07510	COG1321	iron dependent repressor
HV033_RS07515	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV033_RS07520	COG1566	PFAM secretion protein HlyD family protein
HV033_RS07525	COG2814	Major facilitator Superfamily
HV033_RS07535	COG0667	Aldo Keto reductase
HV033_RS07540	COG2723	6-phospho-beta-galactosidase activity
HV033_RS07545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV033_RS07550	COG2188	Transcriptional regulator
HV033_RS07555	COG1376	ErfK ybiS ycfS ynhG family protein
HV033_RS07560	COG0488	(ABC) transporter
HV033_RS07570	COG2271	Major facilitator Superfamily
HV033_RS07575	COG1609	Transcriptional regulator
HV033_RS07585	COG0561	phosphatase activity
HV033_RS07590	COG1882	Formate acetyltransferase
HV033_RS07595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV033_RS07600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV033_RS07610	COG0303	'Molybdopterin
HV033_RS07615	COG1446	asparaginase
HV033_RS07650	COG2133	pyrroloquinoline quinone binding
HV033_RS07655	COG0625	glutathione transferase activity
HV033_RS07660	COG1686	Belongs to the peptidase S11 family
HV033_RS07665	COG1349	DNA-binding transcription factor activity
HV033_RS07670	COG0671	phosphoesterase, PA-phosphatase related
HV033_RS07680	COG2814	Major facilitator Superfamily
HV033_RS07685	COG0561	phosphatase activity
HV033_RS07690	COG0738	Major facilitator superfamily
HV033_RS07695	COG3226	Transcriptional regulator
HV033_RS07700	COG1393	Belongs to the ArsC family
HV033_RS07705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV033_RS07710	COG0640	Transcriptional regulator
HV033_RS07740	COG0778	Nitroreductase
HV033_RS07755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV033_RS07760	COG3842	ATPase activity
HV033_RS07765	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV033_RS07770	COG1177	transmembrane transport
HV033_RS07780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV033_RS07785	COG0745	RESPONSE REGULATOR receiver
HV033_RS07790	COG5002	protein histidine kinase activity
HV033_RS07795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV033_RS07800	COG4160	amino acid transport
HV033_RS07805	COG4215	(ABC) transporter
HV033_RS07810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV033_RS07815	COG1126	abc transporter atp-binding protein
HV033_RS07825	COG0393	Putative heavy-metal-binding
HV033_RS07830	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV033_RS07850	COG3031	protein transport across the cell outer membrane
HV033_RS07855	COG1450	Type ii and iii secretion system protein
HV033_RS07860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV033_RS07865	COG1459	type II secretion system
HV033_RS07870	COG2165	general secretion pathway protein
HV033_RS07880	COG2165	general secretion pathway protein
HV033_RS07905	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HV033_RS07920	COG3397	chitin binding
HV033_RS07925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV033_RS07930	COG0702	epimerase
HV033_RS07935	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV033_RS07940	COG0028	Belongs to the TPP enzyme family
HV033_RS07945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV033_RS07950	COG1151	hydroxylamine reductase activity
HV033_RS07955	COG2431	L-lysine efflux transmembrane transporter activity
HV033_RS07965	COG3593	DNA synthesis involved in DNA repair
HV033_RS07970	COG2990	Protein conserved in bacteria
HV033_RS07975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV033_RS07985	COG1278	Cold shock
HV033_RS07990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HV033_RS07995	COG0542	response to heat
HV033_RS08005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV033_RS08010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HV033_RS08015	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV033_RS08020	COG4988	ABC transporter
HV033_RS08025	COG0492	ferredoxin-NADP+ reductase activity
HV033_RS08035	COG1674	ftsk spoiiie
HV033_RS08035	COG1178	ABC-type Fe3 transport system permease component
HV033_RS08040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HV033_RS08045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV033_RS08050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HV033_RS08055	COG0243	molybdopterin cofactor binding
HV033_RS08060	COG0437	4 iron, 4 sulfur cluster binding
HV033_RS08065	COG3302	dmso reductase anchor subunit
HV033_RS08070	COG0477	Major facilitator Superfamily
HV033_RS08080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV033_RS08085	COG1882	Formate acetyltransferase
HV033_RS08090	COG2116	formate transmembrane transporter activity
HV033_RS08095	COG1944	ATP diphosphatase activity
HV033_RS08100	COG2323	membrane
HV033_RS08105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HV033_RS08110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HV033_RS08115	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HV033_RS08120	COG0539	negative regulation of cytoplasmic translation
HV033_RS08125	COG0776	regulation of translation
HV033_RS08130	COG2333	competence protein COMEC
HV033_RS08130	COG0658	competence protein
HV033_RS08135	COG1132	(ABC) transporter
HV033_RS08145	COG3214	Protein conserved in bacteria
HV033_RS08150	COG2835	tetraacyldisaccharide 4'-kinase activity
HV033_RS08155	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HV033_RS08160	COG3173	Aminoglycoside phosphotransferase
HV033_RS08165	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV033_RS08170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV033_RS08180	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV033_RS08185	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HV033_RS08190	COG2989	Protein conserved in bacteria
HV033_RS08195	COG3108	Peptidase M15
HV033_RS08200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV033_RS08205	COG1448	Aminotransferase
HV033_RS08215	COG0017	Asparaginyl-tRNA synthetase
HV033_RS08220	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HV033_RS08225	COG0308	aminopeptidase N
HV033_RS08235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV033_RS08240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV033_RS08245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV033_RS08250	COG0431	NADPH-dependent FMN reductase
HV033_RS08255	COG0167	dihydroorotate dehydrogenase activity
HV033_RS08265	COG3217	Mosc domain protein beta barrel domain protein
HV033_RS08265	COG0633	Ferredoxin
HV033_RS08270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HV033_RS08270	COG0116	Belongs to the methyltransferase superfamily
HV033_RS08275	COG0488	(ABC) transporter
HV033_RS08280	COG2995	paraquat-inducible protein a
HV033_RS08285	COG3008	intermembrane lipid transfer
HV033_RS08285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV033_RS08290	COG3009	Protein conserved in bacteria
HV033_RS08295	COG3130	regulation of translation
HV033_RS08305	COG1067	ATP-dependent peptidase activity
HV033_RS08310	COG3120	sequence-specific DNA binding
HV033_RS08320	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
HV033_RS08325	COG3070	regulator of competence-specific genes
HV033_RS08330	COG1289	transmembrane transporter activity
HV033_RS08335	COG3304	Inner membrane component domain
HV033_RS08340	COG0210	DNA helicase
HV033_RS08345	COG1803	Methylglyoxal synthase
HV033_RS08350	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HV033_RS08355	COG1832	CoA-binding protein
HV033_RS08365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HV033_RS08370	COG1254	Belongs to the acylphosphatase family
HV033_RS08380	COG0670	Belongs to the BI1 family
HV033_RS08400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV033_RS08410	COG3264	Mechanosensitive ion channel
HV033_RS08410	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HV033_RS08430	COG2239	Acts as a magnesium transporter
HV033_RS08435	COG0586	Pfam SNARE associated Golgi protein
HV033_RS08455	COG3729	General stress protein
HV033_RS08465	COG2233	PERMEase
HV033_RS08470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV033_RS08475	COG0778	Nitroreductase
HV033_RS08480	COG2267	carboxylic ester hydrolase activity
HV033_RS08485	COG0251	oxidation-reduction process
HV033_RS08490	COG1335	isochorismatase
HV033_RS08495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV033_RS08500	COG1309	transcriptional regulator
HV033_RS08510	COG0506	proline dehydrogenase activity
HV033_RS08510	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV033_RS08510	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV033_RS08515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV033_RS08525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV033_RS08545	COG1702	phosphate starvation-inducible protein PhoH
HV033_RS08550	COG1115	amino acid carrier protein
HV033_RS08560	COG1335	isochorismatase
HV033_RS08570	COG0583	DNA-binding transcription factor activity
HV033_RS08585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV033_RS08590	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HV033_RS08595	COG3381	protein complex oligomerization
HV033_RS08645	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV033_RS08660	COG2943	transferase activity, transferring hexosyl groups
HV033_RS08665	COG5645	(Lipo)protein
HV033_RS08680	COG1560	Kdo2-lipid A biosynthetic process
HV033_RS08690	COG2353	YceI-like domain
HV033_RS08695	COG3038	cytochrome b561
HV033_RS08720	COG0418	dihydroorotase activity
HV033_RS08730	COG0477	Major facilitator Superfamily
HV033_RS08735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV033_RS08740	COG3132	Protein of unknown function, DUF480
HV033_RS08775	COG1558	bacterial-type flagellum-dependent cell motility
HV033_RS08785	COG1749	Flagellar hook protein flgE
HV033_RS08795	COG4786	Flagellar basal body rod
HV033_RS08815	COG1256	bacterial-type flagellum assembly
HV033_RS08825	COG2814	Major facilitator Superfamily
HV033_RS08830	COG0583	DNA-binding transcription factor activity
HV033_RS08835	COG1530	ribonuclease E activity
HV033_RS08845	COG0424	maF-like protein
HV033_RS08855	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HV033_RS08860	COG0416	fatty acid biosynthetic process
HV033_RS08865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HV033_RS08880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HV033_RS08885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV033_RS08890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV033_RS08895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV033_RS08905	COG0470	DNA polymerase III
HV033_RS08910	COG0084	hydrolase, TatD family'
HV033_RS08920	COG4773	Receptor
HV033_RS08925	COG0537	adenosine 5'-monophosphoramidase activity
HV033_RS08930	COG5633	Lipoprotein
HV033_RS08935	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HV033_RS08950	COG3150	esterase
HV033_RS08955	COG1252	NADH dehydrogenase
HV033_RS08960	COG3134	Outer membrane lipoprotein
HV033_RS08965	COG1309	transcriptional regulator
HV033_RS08975	COG1388	LysM domain
HV033_RS08975	COG1376	ErfK ybiS ycfS ynhG family protein
HV033_RS08980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV033_RS08985	COG4763	Acyl-transferase
HV033_RS08990	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV033_RS08995	COG1136	(ABC) transporter
HV033_RS09000	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV033_RS09040	COG1943	Transposase
HV033_RS09045	COG2850	peptidyl-arginine hydroxylation
HV033_RS09050	COG2205	protein histidine kinase activity
HV033_RS09065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV033_RS09070	COG2915	High frequency lysogenization protein hflD homolog
HV033_RS09085	COG1187	pseudouridine synthase activity
HV033_RS09090	COG0538	isocitrate dehydrogenase activity
HV033_RS09100	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV033_RS09110	COG2261	transglycosylase associated protein
HV033_RS09125	COG2199	diguanylate cyclase activity
HV033_RS09125	COG2203	Gaf domain
HV033_RS09130	COG3042	response to heat
HV033_RS09140	COG3189	MarR family transcriptional regulator
HV033_RS09145	COG0504	CTP synthase activity
HV033_RS09150	COG2807	transmembrane transport
HV033_RS09155	COG2207	Transcriptional regulator
HV033_RS09160	COG2707	UPF0756 membrane protein
HV033_RS09170	COG2211	Major facilitator Superfamily
HV033_RS09175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV033_RS09200	COG0463	Glycosyl transferase, family 2
HV033_RS09210	COG2246	polysaccharide biosynthetic process
HV033_RS09215	COG3344	reverse transcriptase
HV033_RS09230	COG2718	Belongs to the UPF0229 family
HV033_RS09235	COG2766	serine protein kinase
HV033_RS09240	COG3713	MltA-interacting MipA family protein
HV033_RS09260	COG3139	Protein of unknown function (DUF1315)
HV033_RS09270	COG1335	isochorismatase
HV033_RS09275	COG0252	asparaginase activity
HV033_RS09280	COG0616	signal peptide processing
HV033_RS09285	COG0778	Nitroreductase
HV033_RS09290	COG0709	Synthesizes selenophosphate from selenide and ATP
HV033_RS09295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV033_RS09310	COG0494	nUDIX hydrolase
HV033_RS09315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV033_RS09320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV033_RS09325	COG2897	thiosulfate sulfurtransferase activity
HV033_RS09330	COG4136	ATPase activity
HV033_RS09335	COG4135	transport system, permease component
HV033_RS09340	COG4134	Bacterial extracellular solute-binding protein
HV033_RS09360	COG3138	arginine N-succinyltransferase
HV033_RS09365	COG1012	belongs to the aldehyde dehydrogenase family
HV033_RS09370	COG3724	N-succinylarginine dihydrolase activity
HV033_RS09380	COG3678	ATP-independent chaperone mediated protein folding
HV033_RS09390	COG0322	excinuclease ABC activity
HV033_RS09395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HV033_RS09400	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV033_RS09405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV033_RS09410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV033_RS09415	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV033_RS09420	COG1917	Cupin 2, conserved barrel domain protein
HV033_RS09420	COG2169	Transcriptional regulator
HV033_RS09425	COG1486	melibiose metabolic process
HV033_RS09430	COG3394	polysaccharide catabolic process
HV033_RS09435	COG0753	catalase activity
HV033_RS09450	COG1988	membrane-bound metal-dependent
HV033_RS09455	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS09460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV033_RS09470	COG3001	Fructosamine kinase
HV033_RS09480	COG1105	Belongs to the carbohydrate kinase PfkB family
HV033_RS09490	COG3137	Salt-induced outer membrane protein
HV033_RS09535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HV033_RS09540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV033_RS09540	COG0072	phenylalanine-tRNA ligase activity
HV033_RS09545	COG0776	regulation of translation
HV033_RS09555	COG0386	Belongs to the glutathione peroxidase family
HV033_RS09565	COG0791	NLP P60 protein
HV033_RS09575	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HV033_RS09585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV033_RS09590	COG4558	Periplasmic binding protein
HV033_RS09595	COG3720	iron ion transport
HV033_RS09605	COG4256	Hemin uptake protein
HV033_RS09610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV033_RS09615	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HV033_RS09620	COG0574	Belongs to the PEP-utilizing enzyme family
HV033_RS09620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV033_RS09625	COG2211	Major facilitator Superfamily
HV033_RS09630	COG1472	Belongs to the glycosyl hydrolase 3 family
HV033_RS09645	COG0628	permease
HV033_RS09650	COG0247	lactate metabolic process
HV033_RS09650	COG0277	FAD linked oxidase domain protein
HV033_RS09655	COG2050	protein possibly involved in aromatic compounds catabolism
HV033_RS09665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV033_RS09680	COG3121	Chaperone
HV033_RS09705	COG3383	formate dehydrogenase (NAD+) activity
HV033_RS09725	COG2200	EAL domain
HV033_RS09730	COG0789	Transcriptional regulator
HV033_RS09750	COG0316	Belongs to the HesB IscA family
HV033_RS09755	COG0719	Fe-S assembly protein
HV033_RS09760	COG0396	ATPase activity
HV033_RS09765	COG0719	Fe-S assembly protein
HV033_RS09770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV033_RS09775	COG2166	iron-sulfur cluster assembly
HV033_RS09780	COG1376	ErfK ybiS ycfS ynhG family protein
HV033_RS09795	COG0626	cystathionine gamma-synthase activity
HV033_RS09810	COG2011	ABC-type metal ion transport system permease component
HV033_RS09815	COG1464	Belongs to the NlpA lipoprotein family
HV033_RS09840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV033_RS09850	COG4529	Protein conserved in bacteria
HV033_RS09865	COG0534	Mate efflux family protein
HV033_RS09870	COG0307	riboflavin synthase, alpha
HV033_RS09875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV033_RS09880	COG2814	Major facilitator Superfamily
HV033_RS09885	COG0583	DNA-binding transcription factor activity
HV033_RS09900	COG2814	Major facilitator Superfamily
HV033_RS09910	COG0791	NLP P60 protein
HV033_RS09915	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV033_RS09925	COG0346	lactoylglutathione lyase activity
HV033_RS09930	COG1902	pentaerythritol trinitrate reductase activity
HV033_RS09935	COG1309	transcriptional regulator
HV033_RS09940	COG2194	sulfuric ester hydrolase activity
HV033_RS09945	COG3313	Fe-S protein
HV033_RS09950	COG4989	oxidoreductase activity
HV033_RS09955	COG2032	superoxide dismutase activity
HV033_RS09960	COG1289	transmembrane transporter activity
HV033_RS09965	COG1566	PFAM secretion protein HlyD family protein
HV033_RS09980	COG3706	GGDEF domain
HV033_RS09990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HV033_RS09995	COG3895	Periplasmic Protein
HV033_RS10000	COG0259	pyridoxamine-phosphate oxidase activity
HV033_RS10005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HV033_RS10010	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV033_RS10015	COG0625	glutathione transferase activity
HV033_RS10020	COG3104	oligopeptide transport
HV033_RS10025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV033_RS10095	COG3846	protein secretion by the type IV secretion system
HV033_RS10110	COG3451	type IV secretory pathway VirB4
HV033_RS10120	COG3838	Conjugal transfer protein Trbc
HV033_RS10125	COG4962	Type ii secretion system protein e
HV033_RS10155	COG2076	Multidrug Resistance protein
HV033_RS10165	COG0583	DNA-binding transcription factor activity
HV033_RS10200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV033_RS10205	COG1127	ABC transporter
HV033_RS10275	COG5489	Protein of unknown function (DUF736)
HV033_RS10295	COG3328	transposase activity
HV033_RS10305	COG2003	Belongs to the UPF0758 family
HV033_RS10310	COG4804	nuclease activity
HV033_RS10320	COG0673	inositol 2-dehydrogenase activity
HV033_RS10325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HV033_RS10330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV033_RS10335	COG1263	PTS System
HV033_RS10335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV033_RS10340	COG1609	Transcriptional regulator
HV033_RS10345	COG5339	Protein conserved in bacteria
HV033_RS10355	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV033_RS10355	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV033_RS10370	COG2205	protein histidine kinase activity
HV033_RS10380	COG0745	RESPONSE REGULATOR receiver
HV033_RS10385	COG3136	membrane protein required for alginate biosynthesis
HV033_RS10390	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS10395	COG0531	amino acid
HV033_RS10405	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV033_RS10410	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV033_RS10415	COG0668	transmembrane transport
HV033_RS10420	COG0589	response to stress
HV033_RS10430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV033_RS10435	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HV033_RS10440	COG1473	amidohydrolase
HV033_RS10450	COG0583	DNA-binding transcription factor activity
HV033_RS10455	COG2840	Smr protein MutS2
HV033_RS10465	COG0667	Aldo Keto reductase
HV033_RS10475	COG4993	Dehydrogenase
HV033_RS10520	COG1403	HNH endonuclease
HV033_RS10525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV033_RS10535	COG0628	permease
HV033_RS10540	COG2076	Multidrug Resistance protein
HV033_RS10545	COG2076	Multidrug Resistance protein
HV033_RS10550	COG3591	Belongs to the peptidase S1B family
HV033_RS10565	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV033_RS10570	COG2814	Major facilitator Superfamily
HV033_RS10575	COG0583	DNA-binding transcription factor activity
HV033_RS10580	COG1940	carbohydrate kinase activity
HV033_RS10585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV033_RS10680	COG3141	response to X-ray
HV033_RS10685	COG3381	protein complex oligomerization
HV033_RS10690	COG3302	dmso reductase anchor subunit
HV033_RS10695	COG0437	4 iron, 4 sulfur cluster binding
HV033_RS10700	COG0243	molybdopterin cofactor binding
HV033_RS10735	COG4948	Mandelate Racemase Muconate Lactonizing
HV033_RS10740	COG1063	alcohol dehydrogenase
HV033_RS10745	COG0477	Major facilitator Superfamily
HV033_RS10750	COG0246	Mannitol dehydrogenase
HV033_RS10760	COG0589	response to stress
HV033_RS10765	COG1802	Transcriptional regulator
HV033_RS10770	COG4221	oxidoreductase activity
HV033_RS10785	COG1278	Cold shock
HV033_RS10790	COG2135	peptidase activity
HV033_RS10800	COG3344	reverse transcriptase
HV033_RS10830	COG0598	Magnesium transport protein CorA
HV033_RS10845	COG4993	Dehydrogenase
HV033_RS10870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV033_RS10875	COG2911	Protein conserved in bacteria
HV033_RS10885	COG3784	Protein of unknown function (DUF1318)
HV033_RS10890	COG2207	Transcriptional regulator
HV033_RS10895	COG1012	belongs to the aldehyde dehydrogenase family
HV033_RS10900	COG4251	negative regulation of phosphorylation
HV033_RS10900	COG3706	GGDEF domain
HV033_RS10900	COG5001	Diguanylate cyclase
HV033_RS10900	COG2203	Gaf domain
HV033_RS10905	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV033_RS10910	COG3733	amine oxidase
HV033_RS10930	COG2030	dehydratase
HV033_RS10930	COG1012	belongs to the aldehyde dehydrogenase family
HV033_RS10935	COG3396	Phenylacetate-CoA oxygenase
HV033_RS10940	COG3460	Phenylacetate-CoA oxygenase
HV033_RS10945	COG3396	Phenylacetate-CoA oxygenase
HV033_RS10950	COG2151	metal-sulfur cluster biosynthetic enzyme
HV033_RS10955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV033_RS10960	COG1024	Enoyl-CoA hydratase
HV033_RS10965	COG1024	Enoyl-CoA hydratase
HV033_RS10970	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV033_RS10975	COG2050	protein possibly involved in aromatic compounds catabolism
HV033_RS10980	COG0183	Belongs to the thiolase family
HV033_RS10985	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HV033_RS10990	COG3327	negative regulation of DNA-templated transcription, initiation
HV033_RS10995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV033_RS11000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV033_RS11010	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV033_RS11030	COG0300	oxidoreductase activity
HV033_RS11045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV033_RS11090	COG3122	Protein conserved in bacteria
HV033_RS11095	COG0564	pseudouridine synthase activity
HV033_RS11105	COG1643	Atp-dependent helicase
HV033_RS11110	COG4122	O-methyltransferase activity
HV033_RS11130	COG0477	Major facilitator Superfamily
HV033_RS11135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV033_RS11140	COG1012	belongs to the aldehyde dehydrogenase family
HV033_RS11145	COG3038	cytochrome b561
HV033_RS11150	COG0673	inositol 2-dehydrogenase activity
HV033_RS11155	COG1349	DNA-binding transcription factor activity
HV033_RS11170	COG2274	protein secretion by the type I secretion system
HV033_RS11225	COG0840	transmembrane signaling receptor activity
HV033_RS11230	COG0583	DNA-binding transcription factor activity
HV033_RS11235	COG5383	Protein conserved in bacteria
HV033_RS11240	COG2272	Belongs to the type-B carboxylesterase lipase family
HV033_RS11305	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HV033_RS11310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV033_RS11315	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV033_RS11320	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV033_RS11325	COG0500	methyltransferase
HV033_RS11330	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV033_RS11335	COG0747	negative chemotaxis
HV033_RS11345	COG0697	spore germination
HV033_RS11355	COG3135	benzoate transporter
HV033_RS11360	COG1396	sequence-specific DNA binding
HV033_RS11365	COG0826	peptidase U32
HV033_RS11380	COG4977	sequence-specific DNA binding
HV033_RS11390	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HV033_RS11410	COG1129	ABC transporter
HV033_RS11420	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV033_RS11425	COG2814	Major facilitator Superfamily
HV033_RS11430	COG0697	spore germination
HV033_RS11445	COG1846	Transcriptional regulator
HV033_RS11455	COG2814	Major facilitator Superfamily
HV033_RS11475	COG0583	DNA-binding transcription factor activity
HV033_RS11480	COG1012	belongs to the aldehyde dehydrogenase family
HV033_RS11490	COG2066	Belongs to the glutaminase family
HV033_RS11500	COG3706	GGDEF domain
HV033_RS11510	COG0246	Mannitol dehydrogenase
HV033_RS11515	COG3781	membrane
HV033_RS11550	COG0596	Alpha beta hydrolase
HV033_RS11555	COG0745	RESPONSE REGULATOR receiver
HV033_RS11560	COG2205	protein histidine kinase activity
HV033_RS11575	COG0494	nUDIX hydrolase
HV033_RS11580	COG1349	DNA-binding transcription factor activity
HV033_RS11590	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS11610	COG2801	Transposase and inactivated derivatives
HV033_RS11630	COG2814	Major facilitator Superfamily
HV033_RS11655	COG3121	Chaperone
HV033_RS11670	COG3121	Chaperone
HV033_RS11715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HV033_RS11725	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS11740	COG0583	DNA-binding transcription factor activity
HV033_RS11750	COG4628	conserved protein (DUF2132)
HV033_RS11760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV033_RS11775	COG0840	transmembrane signaling receptor activity
HV033_RS11805	COG2200	EAL domain
HV033_RS11820	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV033_RS11825	COG0747	negative chemotaxis
HV033_RS11830	COG0601	transmembrane transport
HV033_RS11835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV033_RS11840	COG0444	Belongs to the ABC transporter superfamily
HV033_RS11845	COG4608	Belongs to the ABC transporter superfamily
HV033_RS11850	COG1764	response to oxidative stress
HV033_RS11880	COG0281	malic enzyme
HV033_RS11895	COG0488	(ABC) transporter
HV033_RS11900	COG1064	alcohol dehydrogenase
HV033_RS11910	COG1252	NADH dehydrogenase
HV033_RS11915	COG2814	Major facilitator Superfamily
HV033_RS11930	COG2864	formate dehydrogenase
HV033_RS11935	COG0437	4 iron, 4 sulfur cluster binding
HV033_RS11945	COG0697	spore germination
HV033_RS11965	COG2223	nitrite transmembrane transporter activity
HV033_RS11970	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV033_RS11975	COG1140	nitrate reductase beta subunit
HV033_RS11980	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV033_RS11985	COG2181	nitrate reductase activity
HV033_RS11990	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV033_RS11995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV033_RS12010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HV033_RS12015	COG0640	Transcriptional regulator
HV033_RS12020	COG0583	DNA-binding transcription factor activity
HV033_RS12025	COG0456	acetyltransferase
HV033_RS12035	COG1560	Kdo2-lipid A biosynthetic process
HV033_RS12040	COG1942	4-Oxalocrotonate Tautomerase
HV033_RS12045	COG0625	glutathione transferase activity
HV033_RS12050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV033_RS12055	COG1126	abc transporter atp-binding protein
HV033_RS12070	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV033_RS12075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV033_RS12080	COG1473	amidohydrolase
HV033_RS12085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV033_RS12110	COG4772	TonB-dependent receptor
HV033_RS12115	COG1802	Transcriptional regulator
HV033_RS12120	COG2130	NADP-dependent
HV033_RS12130	COG1247	-acetyltransferase
HV033_RS12135	COG3238	Protein conserved in bacteria
HV033_RS12145	COG0747	negative chemotaxis
HV033_RS12165	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV033_RS12215	COG3615	Tellurite resistance protein tehB
HV033_RS12220	COG3615	Tellurite resistance protein tehB
HV033_RS12230	COG1012	belongs to the aldehyde dehydrogenase family
HV033_RS12235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV033_RS12245	COG1271	oxidase subunit
HV033_RS12250	COG1294	oxidase, subunit
HV033_RS12260	COG3187	Heat shock protein
HV033_RS12265	COG3042	response to heat
HV033_RS12270	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV033_RS12270	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV033_RS12270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV033_RS12270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV033_RS12275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV033_RS12295	COG0513	Belongs to the DEAD box helicase family
HV033_RS12310	COG0840	transmembrane signaling receptor activity
HV033_RS12370	COG4166	transmembrane transport
HV033_RS12375	COG2866	Carboxypeptidase
HV033_RS12380	COG4948	Mandelate Racemase Muconate Lactonizing
HV033_RS12385	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV033_RS12395	COG3768	UPF0283 membrane protein
HV033_RS12400	COG3106	COG3106 Predicted ATPase
HV033_RS12405	COG1609	Transcriptional regulator
HV033_RS12415	COG3842	ATPase activity
HV033_RS12420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV033_RS12425	COG1554	hydrolase, family 65, central catalytic
HV033_RS12430	COG0673	inositol 2-dehydrogenase activity
HV033_RS12435	COG1082	Xylose isomerase domain protein TIM barrel
HV033_RS12440	COG1063	alcohol dehydrogenase
HV033_RS12445	COG0395	ABC-type sugar transport system, permease component
HV033_RS12450	COG1175	transmembrane transport
HV033_RS12455	COG1653	transport
HV033_RS12460	COG0366	Alpha amylase catalytic
HV033_RS12470	COG1983	PspC domain protein
HV033_RS12480	COG1842	Phage shock protein A
HV033_RS12485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV033_RS12500	COG4171	peptide transport system, permease
HV033_RS12510	COG4172	Belongs to the ABC transporter superfamily
HV033_RS12515	COG1309	transcriptional regulator
HV033_RS12520	COG0251	oxidation-reduction process
HV033_RS12525	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV033_RS12530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV033_RS12530	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV033_RS12535	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HV033_RS12540	COG5001	Diguanylate cyclase
HV033_RS12545	COG1024	Enoyl-CoA hydratase
HV033_RS12555	COG1349	DNA-binding transcription factor activity
HV033_RS12565	COG0023	Translation Initiation Factor
HV033_RS12570	COG0284	orotidine-5'-phosphate decarboxylase activity
HV033_RS12575	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV033_RS12580	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV033_RS12585	COG0671	phosphoesterase, PA-phosphatase related
HV033_RS12595	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV033_RS12625	COG0616	signal peptide processing
HV033_RS12630	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS12635	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HV033_RS12645	COG0009	L-threonylcarbamoyladenylate synthase
HV033_RS12650	COG0613	PHP domain protein
HV033_RS12660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HV033_RS12665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV033_RS12665	COG0512	Glutamine amidotransferase of anthranilate synthase
HV033_RS12675	COG0133	tryptophan synthase activity
HV033_RS12680	COG0159	tryptophan synthase activity
HV033_RS12685	COG2391	methyltransferase activity
HV033_RS12690	COG0425	Belongs to the sulfur carrier protein TusA family
HV033_RS12695	COG3047	cAMP biosynthetic process
HV033_RS12700	COG0727	PFAM Uncharacterised protein family (UPF0153)
HV033_RS12730	COG2350	Protein conserved in bacteria
HV033_RS12750	COG1280	lysine exporter protein (LysE YggA)
HV033_RS12770	COG3099	Belongs to the UPF0263 family
HV033_RS12775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV033_RS12780	COG4608	Belongs to the ABC transporter superfamily
HV033_RS12785	COG0444	Belongs to the ABC transporter superfamily
HV033_RS12805	COG2095	MarC family integral membrane protein
HV033_RS12810	COG1454	alcohol dehydrogenase
HV033_RS12810	COG1012	belongs to the aldehyde dehydrogenase family
HV033_RS12815	COG1435	thymidine kinase activity
HV033_RS12825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV033_RS12830	COG0745	RESPONSE REGULATOR receiver
HV033_RS12835	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV033_RS12840	COG3012	SEC-C Motif Domain Protein
HV033_RS12845	COG0788	formyltetrahydrofolate deformylase activity
HV033_RS12860	COG2181	nitrate reductase activity
HV033_RS12865	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV033_RS12870	COG1140	nitrate reductase beta subunit
HV033_RS12875	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV033_RS12880	COG2223	nitrite transmembrane transporter activity
HV033_RS12885	COG3850	Histidine kinase
HV033_RS12890	COG2197	response regulator
HV033_RS12895	COG4932	domain protein
HV033_RS12900	COG0243	molybdopterin cofactor binding
HV033_RS12905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV033_RS12905	COG2146	nitrite reductase [NAD(P)H] activity
HV033_RS12910	COG1116	anion transmembrane transporter activity
HV033_RS12920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV033_RS12925	COG3707	response regulator
HV033_RS12930	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV033_RS12935	COG0840	transmembrane signaling receptor activity
HV033_RS12945	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV033_RS12950	COG4572	Cation transport regulator
HV033_RS12955	COG0387	Pfam Sodium calcium exchanger
HV033_RS12960	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HV033_RS12975	COG2890	protein-(glutamine-N5) methyltransferase activity
HV033_RS12985	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HV033_RS12995	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HV033_RS13005	COG0659	secondary active sulfate transmembrane transporter activity
HV033_RS13020	COG0193	aminoacyl-tRNA hydrolase activity
HV033_RS13025	COG0012	GTP binding
HV033_RS13040	COG3209	COG3209 Rhs family protein
HV033_RS13055	COG3501	Rhs element vgr protein
HV033_RS13075	COG0515	serine threonine protein kinase
HV033_RS13205	COG4977	sequence-specific DNA binding
HV033_RS13210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV033_RS13220	COG4774	siderophore transport
HV033_RS13230	COG0741	lytic transglycosylase activity
HV033_RS13235	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV033_RS13240	COG3263	regulation of cellular component size
HV033_RS13245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV033_RS13250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV033_RS13255	COG2719	SpoVR family
HV033_RS13265	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV033_RS13275	COG2983	Belongs to the UPF0260 family
HV033_RS13280	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV033_RS13290	COG0850	regulation of cytokinetic process
HV033_RS13295	COG2894	cell division
HV033_RS13300	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HV033_RS13305	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV033_RS13310	COG0318	PFAM AMP-dependent synthetase and ligase
HV033_RS13315	COG3065	identical protein binding
HV033_RS13320	COG1214	PFAM Peptidase M22, glycoprotease
HV033_RS13325	COG1199	ATP-dependent helicase activity
HV033_RS13330	COG0251	oxidation-reduction process
HV033_RS13335	COG3140	Belongs to the UPF0181 family
HV033_RS13350	COG1760	l-serine dehydratase
HV033_RS13355	COG2200	EAL domain
HV033_RS13360	COG1253	flavin adenine dinucleotide binding
HV033_RS13365	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV033_RS13365	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV033_RS13370	COG3715	PTS system
HV033_RS13375	COG3716	PTS system mannose fructose sorbose family IID component
HV033_RS13380	COG4811	Protein of unknown function (DUF986)
HV033_RS13385	COG1971	Probably functions as a manganese efflux pump
HV033_RS13390	COG2226	methyltransferase
HV033_RS13395	COG0768	penicillin binding
HV033_RS13425	COG1414	Transcriptional regulator
HV033_RS13430	COG2814	Major facilitator Superfamily
HV033_RS13435	COG0501	Belongs to the peptidase M48B family
HV033_RS13445	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HV033_RS13450	COG1956	GAF domain-containing protein
HV033_RS13455	COG2995	paraquat-inducible protein a
HV033_RS13460	COG3008	intermembrane lipid transfer
HV033_RS13465	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HV033_RS13465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HV033_RS13480	COG2990	Protein conserved in bacteria
HV033_RS13495	COG1276	copper resistance
HV033_RS13510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV033_RS13515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV033_RS13520	COG1770	oligopeptidase
HV033_RS13525	COG2979	Protein of unknown function (DUF533)
HV033_RS13560	COG0800	Aldolase
HV033_RS13565	COG0129	dihydroxy-acid dehydratase activity
HV033_RS13570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV033_RS13575	COG1737	Transcriptional regulator
HV033_RS13585	COG1560	Kdo2-lipid A biosynthetic process
HV033_RS13590	COG0739	heme binding
HV033_RS13595	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV033_RS13605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV033_RS13610	COG2255	four-way junction helicase activity
HV033_RS13615	COG0632	four-way junction helicase activity
HV033_RS13630	COG0494	nUDIX hydrolase
HV033_RS13640	COG1335	isochorismatase
HV033_RS13645	COG1801	Protein of unknown function DUF72
HV033_RS13650	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV033_RS13655	COG2226	methyltransferase
HV033_RS13660	COG0500	methyltransferase
HV033_RS13665	COG3142	Participates in the control of copper homeostasis
HV033_RS13670	COG3102	Protein conserved in bacteria
HV033_RS13675	COG0018	arginyl-trna synthetase
HV033_RS13690	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV033_RS13720	COG0745	RESPONSE REGULATOR receiver
HV033_RS13735	COG0840	transmembrane signaling receptor activity
HV033_RS13770	COG1301	dicarboxylic acid transport
HV033_RS13810	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HV033_RS13820	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV033_RS13830	COG1879	ABC-type sugar transport system periplasmic component
HV033_RS13840	COG1528	Iron-storage protein
HV033_RS13845	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV033_RS13875	COG1528	Iron-storage protein
HV033_RS13885	COG0814	amino acid
HV033_RS13890	COG3012	SEC-C Motif Domain Protein
HV033_RS13890	COG3318	Belongs to the UPF0149 family
HV033_RS13925	COG0583	DNA-binding transcription factor activity
HV033_RS13965	COG2197	response regulator
HV033_RS13975	COG2197	response regulator
HV033_RS14010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV033_RS14015	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HV033_RS14020	COG1516	flagellar protein fliS
HV033_RS14030	COG0366	Alpha amylase catalytic
HV033_RS14040	COG1677	Flagellar hook-basal body complex protein FliE
HV033_RS14050	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HV033_RS14060	COG1157	protein secretion by the type III secretion system
HV033_RS14100	COG1987	bacterial-type flagellum assembly
HV033_RS14110	COG2197	response regulator
HV033_RS14135	COG5475	Uncharacterized small protein (DUF2158)
HV033_RS14140	COG2354	Protein conserved in bacteria
HV033_RS14145	COG0697	spore germination
HV033_RS14150	COG3727	T/G mismatch-specific endonuclease activity
HV033_RS14155	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV033_RS14160	COG1418	mRNA catabolic process
HV033_RS14165	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV033_RS14175	COG3290	protein histidine kinase activity
HV033_RS14180	COG4565	transcriptional regulatory protein
HV033_RS14200	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV033_RS14200	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV033_RS14225	COG0583	DNA-binding transcription factor activity
HV033_RS14270	COG0582	viral genome integration into host DNA
HV033_RS14400	COG3311	Transcriptional regulator
HV033_RS14435	COG1376	ErfK ybiS ycfS ynhG family protein
HV033_RS14440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HV033_RS14455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV033_RS14470	COG0477	Major facilitator Superfamily
HV033_RS14475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV033_RS14480	COG0006	proline dipeptidase activity
HV033_RS14490	COG0534	Mate efflux family protein
HV033_RS14505	COG1289	transmembrane transporter activity
HV033_RS14510	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV033_RS14515	COG3344	reverse transcriptase
HV033_RS14525	COG2925	Exonuclease
HV033_RS14535	COG0531	amino acid
HV033_RS14545	COG0583	DNA-binding transcription factor activity
HV033_RS14550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV033_RS14560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HV033_RS14570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV033_RS14575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV033_RS14575	COG0131	Imidazoleglycerol-phosphate dehydratase
HV033_RS14580	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV033_RS14585	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HV033_RS14590	COG0107	imidazoleglycerol-phosphate synthase activity
HV033_RS14660	COG1091	dTDP-4-dehydrorhamnose reductase activity
HV033_RS14665	COG1088	dTDP-glucose 4,6-dehydratase activity
HV033_RS14680	COG0438	transferase activity, transferring glycosyl groups
HV033_RS14685	COG2327	Polysaccharide pyruvyl transferase
HV033_RS14690	COG2244	polysaccharide biosynthetic process
HV033_RS14695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV033_RS14700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV033_RS14710	COG0297	glycogen (starch) synthase activity
HV033_RS14715	COG1051	belongs to the nudix hydrolase family
HV033_RS14720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV033_RS14725	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV033_RS14730	COG0110	maltose O-acetyltransferase activity
HV033_RS14735	COG1216	Glycosyl transferase, family 2
HV033_RS14745	COG0438	transferase activity, transferring glycosyl groups
HV033_RS14750	COG1045	serine acetyltransferase
HV033_RS14755	COG0463	Glycosyl transferase, family 2
HV033_RS14760	COG3206	protein involved in exopolysaccharide biosynthesis
HV033_RS14760	COG0489	protein tyrosine kinase activity
HV033_RS14775	COG1253	flavin adenine dinucleotide binding
HV033_RS14780	COG2982	Protein involved in outer membrane biogenesis
HV033_RS14785	COG0717	Belongs to the dCTP deaminase family
HV033_RS14795	COG5002	protein histidine kinase activity
HV033_RS14795	COG5001	Diguanylate cyclase
HV033_RS14795	COG3447	MASE1 domain protein
HV033_RS14800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV033_RS14805	COG0443	Heat shock 70 kDa protein
HV033_RS14810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV033_RS14815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV033_RS14820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV033_RS14825	COG0477	Major facilitator Superfamily
HV033_RS14830	COG2205	protein histidine kinase activity
HV033_RS14835	COG0745	RESPONSE REGULATOR receiver
HV033_RS14855	COG1597	lipid kinase activity
HV033_RS14860	COG1830	Aldolase
HV033_RS14865	COG2211	Major facilitator Superfamily
HV033_RS14870	COG1397	ADP-ribosylglycohydrolase
HV033_RS14875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV033_RS14880	COG2188	Transcriptional regulator
HV033_RS14885	COG0351	phosphomethylpyrimidine kinase
HV033_RS14890	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HV033_RS14910	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV033_RS14915	COG0076	glutamate decarboxylase activity
HV033_RS14920	COG0489	protein tyrosine kinase activity
HV033_RS14920	COG3206	protein involved in exopolysaccharide biosynthesis
HV033_RS14925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HV033_RS14945	COG5455	response to cobalt ion
HV033_RS14950	COG0456	acetyltransferase
HV033_RS14955	COG0489	protein tyrosine kinase activity
HV033_RS14965	COG4807	Protein conserved in bacteria
HV033_RS14970	COG3279	Response regulator of the LytR AlgR family
HV033_RS14975	COG3275	phosphorelay sensor kinase activity
HV033_RS14980	COG0789	Transcriptional regulator
HV033_RS14990	COG1174	glycine betaine transport
HV033_RS14995	COG1125	glycine betaine transport
HV033_RS15000	COG1174	glycine betaine transport
HV033_RS15005	COG1732	Glycine betaine
HV033_RS15010	COG1472	Belongs to the glycosyl hydrolase 3 family
HV033_RS15015	COG0277	FAD linked oxidase domain protein
HV033_RS15025	COG1686	Belongs to the peptidase S11 family
HV033_RS15035	COG0586	Pfam SNARE associated Golgi protein
HV033_RS15040	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS15045	COG1538	Outer membrane efflux protein
HV033_RS15050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV033_RS15060	COG1346	cytolysis
HV033_RS15065	COG0295	cytidine deaminase activity
HV033_RS15070	COG2949	membrane
HV033_RS15080	COG1129	ABC transporter
HV033_RS15095	COG2311	Membrane
HV033_RS15105	COG0477	Major facilitator Superfamily
HV033_RS15110	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HV033_RS15115	COG4771	TonB-dependent receptor
HV033_RS15120	COG0833	amino acid
HV033_RS15125	COG0583	DNA-binding transcription factor activity
HV033_RS15130	COG2855	membrane
HV033_RS15135	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HV033_RS15140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV033_RS15140	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV033_RS15140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV033_RS15145	COG1105	Belongs to the carbohydrate kinase PfkB family
HV033_RS15170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HV033_RS15175	COG1312	Catalyzes the dehydration of D-mannonate
HV033_RS15180	COG0246	Mannitol dehydrogenase
HV033_RS15185	COG0523	cobalamin synthesis protein
HV033_RS15190	COG0671	phosphoesterase, PA-phosphatase related
HV033_RS15195	COG0791	NLP P60 protein
HV033_RS15200	COG2200	EAL domain
HV033_RS15205	COG4166	transmembrane transport
HV033_RS15210	COG4174	ABC transporter (Permease)
HV033_RS15215	COG4239	(ABC) transporter, permease
HV033_RS15220	COG4172	Belongs to the ABC transporter superfamily
HV033_RS15230	COG2814	Major facilitator Superfamily
HV033_RS15235	COG1187	pseudouridine synthase activity
HV033_RS15240	COG1061	Type III restriction enzyme res subunit
HV033_RS15250	COG3081	Nucleoid-associated protein
HV033_RS15255	COG3082	Protein of unknown function (DUF1414)
HV033_RS15270	COG3182	Iron-regulated membrane protein
HV033_RS15280	COG0579	oxidoreductase
HV033_RS15285	COG0659	secondary active sulfate transmembrane transporter activity
HV033_RS15290	COG2239	Acts as a magnesium transporter
HV033_RS15295	COG4615	Cyclic peptide transporter
HV033_RS15305	COG2169	Transcriptional regulator
HV033_RS15305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV033_RS15315	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV033_RS15320	COG2198	Histidine kinase
HV033_RS15320	COG0642	Histidine kinase
HV033_RS15340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV033_RS15355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV033_RS15360	COG0584	glycerophosphoryl diester phosphodiesterase
HV033_RS15365	COG2271	Major facilitator Superfamily
HV033_RS15370	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV033_RS15375	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HV033_RS15380	COG0247	lactate metabolic process
HV033_RS15395	COG0642	Histidine kinase
HV033_RS15425	COG1441	menaquinone biosynthetic process
HV033_RS15435	COG0596	Alpha beta hydrolase
HV033_RS15440	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HV033_RS15445	COG1169	isochorismate synthase
HV033_RS15450	COG4575	ribosome binding
HV033_RS15455	COG2153	protein acetylation
HV033_RS15460	COG1234	tRNA 3'-trailer cleavage
HV033_RS15465	COG0784	Response regulator, receiver
HV033_RS15465	COG0835	chemotaxis
HV033_RS15470	COG1007	ATP synthesis coupled electron transport
HV033_RS15475	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV033_RS15480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV033_RS15485	COG0713	ATP synthesis coupled electron transport
HV033_RS15490	COG0839	Belongs to the complex I subunit 6 family
HV033_RS15500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HV033_RS15530	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV033_RS15535	COG0583	DNA-binding transcription factor activity
HV033_RS15540	COG0436	Aminotransferase
HV033_RS15550	COG0471	metal ion transport
HV033_RS15550	COG0490	domain, Protein
HV033_RS15555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV033_RS15580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV033_RS15585	COG3959	Transketolase, thiamine diphosphate binding domain
HV033_RS15590	COG3037	sugar-specific permease SgaT UlaA
HV033_RS15600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV033_RS15605	COG1609	Transcriptional regulator
HV033_RS15615	COG0622	Phosphoesterase
HV033_RS15620	COG0625	glutathione transferase activity
HV033_RS15625	COG0625	glutathione transferase activity
HV033_RS15630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV033_RS15635	COG1090	epimerase
HV033_RS15640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV033_RS15645	COG4598	ABC transporter
HV033_RS15650	COG4160	amino acid transport
HV033_RS15660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV033_RS15670	COG0163	prenyltransferase activity
HV033_RS15675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV033_RS15680	COG1286	toxin biosynthetic process
HV033_RS15685	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV033_RS15690	COG0285	dihydrofolate synthase activity
HV033_RS15695	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HV033_RS15700	COG0586	Pfam SNARE associated Golgi protein
HV033_RS15705	COG0101	tRNA pseudouridine synthase activity
HV033_RS15710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV033_RS15715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV033_RS15730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV033_RS15735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV033_RS15735	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HV033_RS15745	COG3101	peptidyl-lysine hydroxylation
HV033_RS15750	COG0730	response to heat
HV033_RS15770	COG2840	Smr protein MutS2
HV033_RS15775	COG2062	phosphohistidine phosphatase, SixA
HV033_RS15780	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV033_RS15780	COG1024	Enoyl-CoA hydratase
HV033_RS15790	COG3691	Protein conserved in bacteria
HV033_RS15795	COG2067	long-chain fatty acid transport protein
HV033_RS15805	COG2116	formate transmembrane transporter activity
HV033_RS15815	COG1560	Kdo2-lipid A biosynthetic process
HV033_RS15825	COG0436	Aminotransferase
HV033_RS15830	COG3275	phosphorelay sensor kinase activity
HV033_RS15835	COG3279	Response regulator of the LytR AlgR family
HV033_RS15840	COG0837	glucose binding
HV033_RS15850	COG3961	Belongs to the TPP enzyme family
HV033_RS15855	COG0667	Aldo Keto reductase
HV033_RS15865	COG1914	H( )-stimulated, divalent metal cation uptake system
HV033_RS15870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV033_RS15875	COG2199	diguanylate cyclase activity
HV033_RS15875	COG2200	EAL domain
HV033_RS15890	COG3415	Transposase
HV033_RS15895	COG3415	Transposase
HV033_RS15900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HV033_RS15930	COG0583	DNA-binding transcription factor activity
HV033_RS15935	COG0385	Bile acid
HV033_RS15940	COG3530	Putative quorum-sensing-regulated virulence factor
HV033_RS15945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HV033_RS15950	COG3115	cell septum assembly
HV033_RS15965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV033_RS15990	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV033_RS15995	COG4208	sulfate ABC transporter
HV033_RS16000	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV033_RS16005	COG4150	thiosulfate binding
HV033_RS16010	COG2837	iron assimilation
HV033_RS16035	COG0408	coproporphyrinogen oxidase activity
HV033_RS16050	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV033_RS16055	COG5342	invasion associated locus B
HV033_RS16060	COG0494	nUDIX hydrolase
HV033_RS16065	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV033_RS16065	COG0493	'glutamate synthase
HV033_RS16070	COG3850	Histidine kinase
HV033_RS16075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV033_RS16085	COG1393	Belongs to the ArsC family
HV033_RS16090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV033_RS16100	COG0400	carboxylic ester hydrolase activity
HV033_RS16110	COG2321	neutral zinc metallopeptidase
HV033_RS16115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HV033_RS16120	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV033_RS16130	COG2716	regulation of RNA biosynthetic process
HV033_RS16135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV033_RS16140	COG0628	permease
HV033_RS16145	COG4783	chaperone-mediated protein folding
HV033_RS16150	COG1393	Belongs to the ArsC family
HV033_RS16165	COG1446	asparaginase
HV033_RS16180	COG2233	PERMEase
HV033_RS16185	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HV033_RS16190	COG2723	6-phospho-beta-galactosidase activity
HV033_RS16200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV033_RS16215	COG2200	EAL domain
HV033_RS16235	COG3713	MltA-interacting MipA family protein
HV033_RS16240	COG0745	RESPONSE REGULATOR receiver
HV033_RS16260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV033_RS16265	COG2207	Transcriptional regulator
HV033_RS16265	COG3708	Transcriptional regulator
HV033_RS16285	COG3179	chitinase
HV033_RS16310	COG3344	reverse transcriptase
HV033_RS16425	COG5484	DNA packaging
HV033_RS16425	COG3728	DNA packaging
HV033_RS16525	COG3723	Recombinational DNA repair protein, rece pathway
HV033_RS16565	COG0517	IMP dehydrogenase activity
HV033_RS16565	COG0516	GMP reductase activity
HV033_RS16570	COG1570	exodeoxyribonuclease VII activity
HV033_RS16585	COG1645	bacterial-type flagellum-dependent swarming motility
HV033_RS16590	COG3104	oligopeptide transport
HV033_RS16595	COG1160	GTP binding
HV033_RS16605	COG2976	Protein conserved in bacteria
HV033_RS16610	COG0124	histidyl-tRNA synthetase
HV033_RS16615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HV033_RS16625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HV033_RS16640	COG3302	dmso reductase anchor subunit
HV033_RS16645	COG0437	4 iron, 4 sulfur cluster binding
HV033_RS16650	COG0243	molybdopterin cofactor binding
HV033_RS16655	COG4953	penicillin-binding protein 1C
HV033_RS16660	COG2373	Large extracellular alpha-helical protein
HV033_RS16665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV033_RS16665	COG1263	PTS System
HV033_RS16665	COG2190	(PTS) system
HV033_RS16675	COG2897	thiosulfate sulfurtransferase activity
HV033_RS16680	COG1737	Transcriptional regulator
HV033_RS16690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HV033_RS16695	COG2975	iron-sulfur cluster assembly
HV033_RS16700	COG0633	Ferredoxin
HV033_RS16705	COG0443	Heat shock 70 kDa protein
HV033_RS16710	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV033_RS16715	COG0316	Belongs to the HesB IscA family
HV033_RS16720	COG0822	iron-sulfur transferase activity
HV033_RS16725	COG1104	cysteine desulfurase activity
HV033_RS16745	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV033_RS16755	COG3711	transcriptional antiterminator
HV033_RS16760	COG2814	Major facilitator Superfamily
HV033_RS16765	COG2259	Doxx family
HV033_RS16775	COG1017	nitric oxide dioxygenase activity
HV033_RS16775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV033_RS16780	COG0347	Belongs to the P(II) protein family
HV033_RS16785	COG2204	response regulator
HV033_RS16790	COG3170	Tfp pilus assembly protein FimV
HV033_RS16795	COG2205	protein histidine kinase activity
HV033_RS16800	COG0047	phosphoribosylformylglycinamidine synthase activity
HV033_RS16800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HV033_RS16805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV033_RS16815	COG0560	Phosphoserine phosphatase
HV033_RS16820	COG1263	PTS System
HV033_RS16820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV033_RS16825	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV033_RS16830	COG1737	Transcriptional regulator
HV033_RS16835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV033_RS16845	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV033_RS16850	COG1381	Involved in DNA repair and RecF pathway recombination
HV033_RS16865	COG0681	Belongs to the peptidase S26 family
HV033_RS16875	COG3086	response to oxidative stress
HV033_RS16895	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV033_RS16900	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HV033_RS16905	COG0513	Belongs to the DEAD box helicase family
HV033_RS16910	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HV033_RS16915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HV033_RS16920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV033_RS16925	COG3118	belongs to the thioredoxin family
HV033_RS16935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV033_RS16935	COG1042	CoA-binding domain protein
HV033_RS16935	COG0045	succinate-CoA ligase (ADP-forming) activity
HV033_RS16940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV033_RS16945	COG5544	Lipoprotein
HV033_RS16950	COG0477	Major facilitator Superfamily
HV033_RS16980	COG0542	response to heat
HV033_RS16990	COG0564	pseudouridine synthase activity
HV033_RS16995	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV033_RS17000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV033_RS17010	COG1605	Chorismate mutase
HV033_RS17010	COG0077	Prephenate dehydratase
HV033_RS17020	COG0287	Prephenate dehydrogenase
HV033_RS17020	COG1605	Chorismate mutase
HV033_RS17025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV033_RS17035	COG2199	diguanylate cyclase activity
HV033_RS17040	COG2885	chlorophyll binding
HV033_RS17060	COG0336	Belongs to the RNA methyltransferase TrmD family
HV033_RS17065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HV033_RS17075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV033_RS17080	COG4137	Cytochrome C assembly protein
HV033_RS17085	COG4536	flavin adenine dinucleotide binding
HV033_RS17090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HV033_RS17095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HV033_RS17100	COG0497	DNA recombination
HV033_RS17115	COG2867	negative regulation of translational initiation
HV033_RS17230	COG4695	Portal protein
HV033_RS17235	COG4626	Terminase
HV033_RS17235	COG1802	Transcriptional regulator
HV033_RS17265	COG3179	chitinase
HV033_RS17285	COG0484	heat shock protein binding
HV033_RS17305	COG4197	protein conserved in bacteria, prophage-related
HV033_RS17350	COG0582	viral genome integration into host DNA
HV033_RS17375	COG0154	amidase activity
HV033_RS17380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HV033_RS17400	COG2814	Major facilitator Superfamily
HV033_RS17405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HV033_RS17410	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS17415	COG2226	methyltransferase
HV033_RS17415	COG1073	alpha beta
HV033_RS17430	COG0583	DNA-binding transcription factor activity
HV033_RS17440	COG1917	Cupin 2, conserved barrel domain protein
HV033_RS17440	COG4977	sequence-specific DNA binding
HV033_RS17445	COG4221	oxidoreductase activity
HV033_RS17450	COG4221	oxidoreductase activity
HV033_RS17465	COG0583	DNA-binding transcription factor activity
HV033_RS17470	COG0402	S-adenosylhomocysteine deaminase activity
HV033_RS17475	COG0549	Belongs to the carbamate kinase family
HV033_RS17485	COG1304	FMN binding
HV033_RS17490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV033_RS17495	COG0666	response to abiotic stimulus
HV033_RS17500	COG0583	DNA-binding transcription factor activity
HV033_RS17505	COG0401	homolog of Blt101
HV033_RS17510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV033_RS17535	COG4575	ribosome binding
HV033_RS17545	COG1780	Probably involved in ribonucleotide reductase function
HV033_RS17550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV033_RS17560	COG4175	Glycine betaine
HV033_RS17565	COG4176	ABC-type proline glycine betaine transport system permease component
HV033_RS17575	COG2814	Major facilitator Superfamily
HV033_RS17580	COG1846	Transcriptional regulator
HV033_RS17585	COG1566	PFAM secretion protein HlyD family protein
HV033_RS17590	COG2814	Major facilitator Superfamily
HV033_RS17600	COG2918	glutathione biosynthetic process
HV033_RS17605	COG1238	metal cluster binding
HV033_RS17610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV033_RS17640	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV033_RS17645	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HV033_RS17660	COG1546	Belongs to the CinA family
HV033_RS17670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV033_RS17680	COG2951	lytic endotransglycosylase activity
HV033_RS17685	COG3730	PTS system glucitol sorbitol-specific
HV033_RS17690	COG3732	PTS system glucitol sorbitol-specific
HV033_RS17700	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS17705	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV033_RS17710	COG1349	DNA-binding transcription factor activity
HV033_RS17720	COG3604	Transcriptional regulator
HV033_RS17725	COG0426	domain, Protein
HV033_RS17725	COG1773	rubredoxin
HV033_RS17730	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV033_RS17735	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV033_RS17740	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV033_RS17745	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV033_RS17750	COG1609	Transcriptional regulator
HV033_RS17755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV033_RS17755	COG1263	PTS System
HV033_RS17760	COG2723	6-phospho-beta-galactosidase activity
HV033_RS17765	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV033_RS17775	COG3260	NADH ubiquinone oxidoreductase 20
HV033_RS17780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV033_RS17785	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV033_RS17785	COG3261	NADH dehydrogenase
HV033_RS17790	COG0650	Formate hydrogenlyase subunit 4
HV033_RS17795	COG0651	ATP synthesis coupled electron transport
HV033_RS17800	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV033_RS17810	COG0375	protein maturation
HV033_RS17815	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV033_RS17820	COG0298	carbon dioxide binding
HV033_RS17825	COG0409	Hydrogenase expression formation protein
HV033_RS17830	COG0309	Hydrogenase expression formation protein (HypE)
HV033_RS17850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HV033_RS17860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV033_RS17865	COG0163	prenyltransferase activity
HV033_RS17880	COG0477	Major facilitator Superfamily
HV033_RS17895	COG1388	LysM domain
HV033_RS17895	COG4942	peptidase
HV033_RS17910	COG0585	pseudouridine synthase activity
HV033_RS17915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HV033_RS17920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HV033_RS17925	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HV033_RS17935	COG0529	Catalyzes the synthesis of activated sulfate
HV033_RS17955	COG2234	aminopeptidase activity
HV033_RS17970	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HV033_RS17975	COG0720	synthase
HV033_RS17980	COG2207	Transcriptional regulator
HV033_RS17985	COG1473	amidohydrolase
HV033_RS17995	COG0602	queuosine metabolic process
HV033_RS18000	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HV033_RS18005	COG1263	PTS System
HV033_RS18005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV033_RS18005	COG2190	(PTS) system
HV033_RS18010	COG1737	Transcriptional regulator
HV033_RS18025	COG3956	TIGRFAM MazG family protein
HV033_RS18030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV033_RS18035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV033_RS18040	COG3437	response regulator, receiver
HV033_RS18040	COG2205	protein histidine kinase activity
HV033_RS18040	COG3850	Histidine kinase
HV033_RS18040	COG4999	Histidine kinase
HV033_RS18045	COG1929	Belongs to the glycerate kinase type-1 family
HV033_RS18050	COG4948	Mandelate Racemase Muconate Lactonizing
HV033_RS18055	COG4948	Mandelate Racemase Muconate Lactonizing
HV033_RS18060	COG2271	Major facilitator Superfamily
HV033_RS18065	COG0716	FMN binding
HV033_RS18070	COG0564	pseudouridine synthase activity
HV033_RS18075	COG3098	single-species biofilm formation
HV033_RS18090	COG1611	Belongs to the LOG family
HV033_RS18095	COG0814	amino acid
HV033_RS18100	COG1760	l-serine dehydratase
HV033_RS18110	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HV033_RS18115	COG2363	Small membrane protein
HV033_RS18120	COG0583	DNA-binding transcription factor activity
HV033_RS18130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV033_RS18135	COG2166	iron-sulfur cluster assembly
HV033_RS18140	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV033_RS18145	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV033_RS18165	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV033_RS18170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV033_RS18170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV033_RS18175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV033_RS18180	COG1074	ATP-dependent DNA helicase activity
HV033_RS18190	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV033_RS18195	COG4967	type IV pilus modification protein PilV
HV033_RS18205	COG4795	General secretion pathway protein
HV033_RS18210	COG2165	general secretion pathway protein
HV033_RS18215	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HV033_RS18220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HV033_RS18230	COG0494	nUDIX hydrolase
HV033_RS18235	COG3066	DNA modification
HV033_RS18245	COG0667	Aldo Keto reductase
HV033_RS18250	COG0477	Major facilitator Superfamily
HV033_RS18255	COG0204	Acyl-transferase
HV033_RS18255	COG0318	PFAM AMP-dependent synthetase and ligase
HV033_RS18260	COG1609	Transcriptional regulator
HV033_RS18270	COG2186	Transcriptional regulator
HV033_RS18275	COG2723	6-phospho-beta-galactosidase activity
HV033_RS18280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV033_RS18285	COG1609	Transcriptional regulator
HV033_RS18295	COG0583	DNA-binding transcription factor activity
HV033_RS18300	COG1794	racemase activity, acting on amino acids and derivatives
HV033_RS18310	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV033_RS18315	COG1175	transmembrane transport
HV033_RS18320	COG0395	ABC-type sugar transport system, permease component
HV033_RS18325	COG3842	ATPase activity
HV033_RS18335	COG2814	Major facilitator Superfamily
HV033_RS18340	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS18345	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HV033_RS18350	COG0823	Involved in the tonB-independent uptake of proteins
HV033_RS18355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV033_RS18360	COG0183	Belongs to the thiolase family
HV033_RS18375	COG0814	amino acid
HV033_RS18380	COG2388	GCN5-related N-acetyl-transferase
HV033_RS18385	COG3592	Divergent 4Fe-4S mono-cluster
HV033_RS18390	COG3729	General stress protein
HV033_RS18395	COG3685	Protein conserved in bacteria
HV033_RS18400	COG3685	Protein conserved in bacteria
HV033_RS18405	COG3546	catalase activity
HV033_RS18410	COG1271	oxidase subunit
HV033_RS18415	COG1294	oxidase, subunit
HV033_RS18430	COG1546	Belongs to the CinA family
HV033_RS18445	COG3111	PFAM Bacterial OB fold (BOF) protein
HV033_RS18450	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS18455	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV033_RS18475	COG2067	long-chain fatty acid transport protein
HV033_RS18480	COG1280	lysine exporter protein (LysE YggA)
HV033_RS18495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV033_RS18585	COG3328	transposase activity
HV033_RS18590	COG3328	transposase activity
HV033_RS18605	COG4942	peptidase
HV033_RS18610	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HV033_RS18615	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HV033_RS18625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV033_RS18635	COG4974	Belongs to the 'phage' integrase family
HV033_RS18650	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV033_RS18655	COG0354	folic acid binding
HV033_RS18660	COG1272	protein, Hemolysin III
HV033_RS18665	COG1737	Transcriptional regulator
HV033_RS18670	COG2723	6-phospho-beta-galactosidase activity
HV033_RS18690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV033_RS18695	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS18700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HV033_RS18700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HV033_RS18710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HV033_RS18715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV033_RS18720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV033_RS18725	COG0006	proline dipeptidase activity
HV033_RS18735	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HV033_RS18745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV033_RS18750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV033_RS18760	COG0583	DNA-binding transcription factor activity
HV033_RS18765	COG2968	Membrane
HV033_RS18770	COG1279	arginine transmembrane transporter activity
HV033_RS18775	COG0668	transmembrane transport
HV033_RS18780	COG0191	fructose-bisphosphate aldolase activity
HV033_RS18785	COG0126	phosphoglycerate kinase activity
HV033_RS18790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV033_RS18795	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV033_RS18800	COG0501	Belongs to the peptidase M48B family
HV033_RS18815	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HV033_RS18820	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS18825	COG2267	carboxylic ester hydrolase activity
HV033_RS18850	COG1414	Transcriptional regulator
HV033_RS18855	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS18870	COG2146	nitrite reductase [NAD(P)H] activity
HV033_RS18880	COG0010	Belongs to the arginase family
HV033_RS18885	COG1166	arginine decarboxylase activity
HV033_RS18905	COG2814	Major facilitator Superfamily
HV033_RS18910	COG3091	SprT-like family
HV033_RS18915	COG2356	endonuclease I
HV033_RS18920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV033_RS18940	COG2805	Type II/IV secretion system protein
HV033_RS18945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV033_RS18950	COG0762	integral membrane protein
HV033_RS18955	COG1872	DUF167
HV033_RS18965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV033_RS18970	COG2852	Protein conserved in bacteria
HV033_RS18980	COG3171	Protein conserved in bacteria
HV033_RS18990	COG1194	a g-specific adenine glycosylase
HV033_RS19000	COG0741	lytic transglycosylase activity
HV033_RS19005	COG2211	Major facilitator Superfamily
HV033_RS19010	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HV033_RS19030	COG3052	prosthetic group binding
HV033_RS19040	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV033_RS19045	COG3493	citrate carrier protein
HV033_RS19060	COG1982	Orn Lys Arg decarboxylase major
HV033_RS19065	COG1811	Na channel or pump
HV033_RS19075	COG0582	viral genome integration into host DNA
HV033_RS19160	COG5002	protein histidine kinase activity
HV033_RS19165	COG2197	response regulator
HV033_RS19185	COG0457	Tetratricopeptide repeat
HV033_RS19195	COG1215	transferase activity, transferring glycosyl groups
HV033_RS19205	COG0754	glutathionylspermidine amidase activity
HV033_RS19210	COG0625	glutathione transferase activity
HV033_RS19215	COG1349	DNA-binding transcription factor activity
HV033_RS19220	COG0840	transmembrane signaling receptor activity
HV033_RS19240	COG4382	Mu-like prophage protein Gp16
HV033_RS19275	COG3409	Peptidoglycan-binding domain 1 protein
HV033_RS19275	COG3267	Type II secretory pathway component ExeA
HV033_RS19355	COG4373	Mu-like prophage FluMu protein gp28
HV033_RS19365	COG2369	cell adhesion
HV033_RS19485	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV033_RS19505	COG2862	Uncharacterized protein family, UPF0114
HV033_RS19525	COG0848	biopolymer transport protein
HV033_RS19535	COG0626	cystathionine gamma-synthase activity
HV033_RS19540	COG0586	Pfam SNARE associated Golgi protein
HV033_RS19545	COG2207	Transcriptional regulator
HV033_RS19550	COG1979	alcohol dehydrogenase
HV033_RS19595	COG0604	alcohol dehydrogenase
HV033_RS19665	COG0697	spore germination
HV033_RS19675	COG3436	PFAM IS66 Orf2 family protein
HV033_RS19680	COG4372	Transposase
HV033_RS19685	COG1234	tRNA 3'-trailer cleavage
HV033_RS19695	COG1902	pentaerythritol trinitrate reductase activity
HV033_RS19700	COG0640	Transcriptional regulator
HV033_RS19745	COG0204	Acyl-transferase
HV033_RS19755	COG3111	PFAM Bacterial OB fold (BOF) protein
HV033_RS19770	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV033_RS19775	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV033_RS19780	COG1652	LysM domain
HV033_RS19790	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV033_RS19795	COG2211	Major facilitator Superfamily
HV033_RS19820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV033_RS19825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV033_RS19830	COG1120	ATPase activity
HV033_RS19835	COG4774	siderophore transport
HV033_RS19840	COG0187	DNA topoisomerase II activity
HV033_RS19845	COG3150	esterase
HV033_RS19850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV033_RS19855	COG3151	Protein conserved in bacteria
HV033_RS19860	COG0494	nUDIX hydrolase
HV033_RS19875	COG0754	glutathionylspermidine amidase activity
HV033_RS19880	COG3384	dioxygenase
HV033_RS19890	COG3539	Fimbrial protein
HV033_RS19895	COG3188	usher protein
HV033_RS19900	COG3121	Chaperone
HV033_RS19905	COG3539	Fimbrial protein
HV033_RS19910	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HV033_RS19920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HV033_RS19920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HV033_RS19930	COG3025	triphosphatase activity
HV033_RS19935	COG4991	sh3 domain protein
HV033_RS19940	COG0617	tRNA 3'-terminal CCA addition
HV033_RS19950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV033_RS19960	COG2271	Major facilitator Superfamily
HV033_RS19965	COG0829	nickel cation binding
HV033_RS19970	COG0831	urea catabolic process
HV033_RS19975	COG0832	Belongs to the urease beta subunit family
HV033_RS19980	COG0804	urea catabolic process
HV033_RS19985	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HV033_RS19995	COG0830	nickel cation binding
HV033_RS20000	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV033_RS20010	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV033_RS20015	COG0358	DNA primase activity
HV033_RS20025	COG3663	DNA glycosylase
HV033_RS20170	COG4695	Portal protein
HV033_RS20180	COG3039	Transposase
HV033_RS20210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV033_RS20245	COG4974	Belongs to the 'phage' integrase family
HV033_RS20280	COG2375	cellular response to nickel ion
HV033_RS20285	COG1695	Transcriptional regulator
HV033_RS20290	COG0840	transmembrane signaling receptor activity
HV033_RS20295	COG0840	transmembrane signaling receptor activity
HV033_RS20300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV033_RS20305	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV033_RS20310	COG1830	Aldolase
HV033_RS20315	COG1879	ABC-type sugar transport system periplasmic component
HV033_RS20320	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV033_RS20325	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV033_RS20330	COG1129	ABC transporter
HV033_RS20335	COG2390	Transcriptional regulator
HV033_RS20340	COG1070	Carbohydrate kinase
HV033_RS20345	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV033_RS20345	COG1902	pentaerythritol trinitrate reductase activity
HV033_RS20355	COG1451	nucleotide metabolic process
HV033_RS20360	COG0673	inositol 2-dehydrogenase activity
HV033_RS20365	COG0861	Integral membrane protein TerC family
HV033_RS20375	COG2721	sulfolactate sulfo-lyase activity
HV033_RS20385	COG2271	Major facilitator Superfamily
HV033_RS20390	COG2186	Transcriptional regulator
HV033_RS20395	COG0586	Pfam SNARE associated Golgi protein
HV033_RS20405	COG1422	Protein of unknown function (DUF1090)
HV033_RS20410	COG4575	ribosome binding
HV033_RS20415	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV033_RS20425	COG2259	Doxx family
HV033_RS20430	COG0435	Glutathione S-transferase
HV033_RS20435	COG3152	Membrane
HV033_RS20440	COG0583	DNA-binding transcription factor activity
HV033_RS20445	COG1741	Belongs to the pirin family
HV033_RS20455	COG0814	amino acid
HV033_RS20460	COG1882	Formate acetyltransferase
HV033_RS20465	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HV033_RS20470	COG0814	amino acid
HV033_RS20490	COG0583	DNA-binding transcription factor activity
HV033_RS20500	COG1929	Belongs to the glycerate kinase type-1 family
HV033_RS20505	COG2084	Dehydrogenase
HV033_RS20515	COG2721	sulfolactate sulfo-lyase activity
HV033_RS20520	COG1349	DNA-binding transcription factor activity
HV033_RS20530	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV033_RS20540	COG3716	PTS system mannose fructose sorbose family IID component
HV033_RS20545	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV033_RS20550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV033_RS20555	COG2222	sugar isomerase
HV033_RS20560	COG0191	fructose-bisphosphate aldolase activity
HV033_RS20565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV033_RS20565	COG1263	PTS System
HV033_RS20580	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV033_RS20585	COG3107	peptidoglycan biosynthetic process
HV033_RS20590	COG0792	nuclease activity
HV033_RS20595	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HV033_RS20600	COG2823	Periplasmic or secreted lipoprotein
HV033_RS20605	COG0701	Predicted permease
HV033_RS20610	COG0702	epimerase
HV033_RS20615	COG0693	protein deglycase activity
HV033_RS20620	COG3787	Belongs to the UPF0306 family
HV033_RS20625	COG2827	Endonuclease containing a URI domain
HV033_RS20630	COG3153	acetyltransferase
HV033_RS20635	COG3154	lipid carrier protein
HV033_RS20640	COG0826	peptidase U32
HV033_RS20645	COG0826	peptidase U32
HV033_RS20650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV033_RS20655	COG0814	amino acid
HV033_RS20660	COG0513	Belongs to the DEAD box helicase family
HV033_RS20675	COG1185	polyribonucleotide nucleotidyltransferase activity
HV033_RS20680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HV033_RS20685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HV033_RS20690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV033_RS20695	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HV033_RS20715	COG0137	argininosuccinate synthase activity
HV033_RS20725	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV033_RS20730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV033_RS20735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV033_RS20745	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HV033_RS20750	COG1534	Rna-binding protein
HV033_RS20760	COG2027	D-alanyl-D-alanine carboxypeptidase
HV033_RS20765	COG0745	RESPONSE REGULATOR receiver
HV033_RS20770	COG0642	Histidine kinase
HV033_RS20775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HV033_RS20780	COG0697	spore germination
HV033_RS20790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV033_RS20795	COG0142	geranyltranstransferase activity
HV033_RS20800	COG3423	Transcriptional regulator
HV033_RS20805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HV033_RS20810	COG5007	Belongs to the BolA IbaG family
HV033_RS20815	COG3113	response to antibiotic
HV033_RS20820	COG2854	intermembrane phospholipid transfer
HV033_RS20825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV033_RS20830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV033_RS20835	COG1127	ABC transporter
HV033_RS20840	COG0530	calcium, potassium:sodium antiporter activity
HV033_RS20850	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV033_RS20855	COG3117	lipopolysaccharide transmembrane transporter activity
HV033_RS20860	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV033_RS20865	COG1137	ATPase activity
HV033_RS20870	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HV033_RS20890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV033_RS20900	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV033_RS20905	COG0784	Response regulator, receiver
HV033_RS20905	COG2198	Histidine kinase
HV033_RS20905	COG5002	protein histidine kinase activity
HV033_RS20910	COG0795	lipopolysaccharide-transporting ATPase activity
HV033_RS20915	COG0795	lipopolysaccharide-transporting ATPase activity
HV033_RS20920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HV033_RS20925	COG2927	DNA polymerase III (CHI subunit)
HV033_RS20935	COG0456	acetyltransferase
HV033_RS20940	COG1064	alcohol dehydrogenase
HV033_RS20950	COG0433	COG0433 Predicted ATPase
HV033_RS20955	COG1242	4 iron, 4 sulfur cluster binding
HV033_RS20960	COG0070	glutamate synthase
HV033_RS20960	COG0069	glutamate synthase activity
HV033_RS20960	COG0067	glutamate synthase
HV033_RS20965	COG0493	'glutamate synthase
HV033_RS20970	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV033_RS20975	COG0402	S-adenosylhomocysteine deaminase activity
HV033_RS20980	COG3539	Fimbrial protein
HV033_RS20990	COG3188	usher protein
HV033_RS20995	COG3121	Chaperone
HV033_RS21000	COG3539	Fimbrial protein
HV033_RS21005	COG3539	Fimbrial protein
HV033_RS21010	COG2969	positive regulation of protein catabolic process
HV033_RS21015	COG0625	glutathione transferase activity
HV033_RS21020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HV033_RS21030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV033_RS21035	COG3105	Protein conserved in bacteria
HV033_RS21040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV033_RS21045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV033_RS21055	COG1438	arginine binding
HV033_RS21065	COG2732	(Barnase) inhibitor
HV033_RS21070	COG1012	belongs to the aldehyde dehydrogenase family
HV033_RS21075	COG1289	transmembrane transporter activity
HV033_RS21090	COG0583	DNA-binding transcription factor activity
HV033_RS21095	COG0312	modulator of DNA gyrase
HV033_RS21100	COG3164	Protein of unknown function
HV033_RS21105	COG1530	ribonuclease E activity
HV033_RS21115	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV033_RS21120	COG1792	Involved in formation and maintenance of cell shape
HV033_RS21125	COG1077	Cell shape determining protein MreB Mrl
HV033_RS21130	COG2200	EAL domain
HV033_RS21130	COG2199	diguanylate cyclase activity
HV033_RS21135	COG0604	alcohol dehydrogenase
HV033_RS21145	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HV033_RS21150	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HV033_RS21155	COG0511	ligase activity, forming carbon-carbon bonds
HV033_RS21160	COG0439	Biotin carboxylase
HV033_RS21165	COG3924	membrane
HV033_RS21170	COG4145	pantothenate transmembrane transporter activity
HV033_RS21205	COG1309	transcriptional regulator
HV033_RS21210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV033_RS21215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV033_RS21255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV033_RS21265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV033_RS21270	COG0009	L-threonylcarbamoyladenylate synthase
HV033_RS21275	COG0551	DNA topoisomerase type I activity
HV033_RS21280	COG2922	Belongs to the Smg family
HV033_RS21285	COG0758	DNA mediated transformation
HV033_RS21290	COG0242	peptide deformylase activity
HV033_RS21295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HV033_RS21300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HV033_RS21300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HV033_RS21310	COG1970	mechanosensitive ion channel activity
HV033_RS21315	COG3036	rescue of stalled ribosome
HV033_RS21320	COG0789	Transcriptional regulator
HV033_RS21335	COG0202	RNA polymerase activity
HV033_RS21345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV033_RS21360	COG0201	protein transport
HV033_RS21370	COG1841	ribosomal large subunit assembly
HV033_RS21385	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HV033_RS21390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HV033_RS21420	COG0255	Belongs to the universal ribosomal protein uL29 family
HV033_RS21425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HV033_RS21465	COG0051	transcription antitermination factor activity, RNA binding
HV033_RS21505	COG2168	tRNA wobble position uridine thiolation
HV033_RS21510	COG2923	Belongs to the DsrF TusC family
HV033_RS21515	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV033_RS21520	COG2964	Protein conserved in bacteria
HV033_RS21525	COG0545	Peptidyl-prolyl cis-trans isomerase
HV033_RS21530	COG2900	Belongs to the SlyX family
HV033_RS21535	COG1047	Peptidyl-prolyl cis-trans
HV033_RS21540	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV033_RS21545	COG0475	glutathione-regulated potassium exporter activity
HV033_RS21545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV033_RS21550	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV033_RS21555	COG0488	(ABC) transporter
HV033_RS21565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HV033_RS21575	COG0679	Auxin Efflux Carrier
HV033_RS21605	COG0429	hydrolase of the alpha beta-hydrolase fold
HV033_RS21610	COG3089	Belongs to the UPF0270 family
HV033_RS21615	COG3954	Phosphoribulokinase
HV033_RS21620	COG1765	OsmC-like protein
HV033_RS21630	COG1289	transmembrane transporter activity
HV033_RS21635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV033_RS21640	COG0512	Glutamine amidotransferase of anthranilate synthase
HV033_RS21645	COG2184	nucleotidyltransferase activity
HV033_RS21655	COG0738	Major facilitator superfamily
HV033_RS21660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV033_RS21670	COG1648	precorrin-2 dehydrogenase activity
HV033_RS21670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV033_RS21680	COG0180	Tryptophanyl-tRNA synthetase
HV033_RS21690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV033_RS21695	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV033_RS21700	COG3266	domain, Protein
HV033_RS21705	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HV033_RS21710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV033_RS21715	COG4796	Type ii and iii secretion system protein
HV033_RS21735	COG4972	Pilus assembly protein
HV033_RS21740	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV033_RS21745	COG0494	nUDIX hydrolase
HV033_RS21755	COG1011	Hydrolase
HV033_RS21760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV033_RS21765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HV033_RS21770	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV033_RS21775	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HV033_RS21785	COG0745	RESPONSE REGULATOR receiver
HV033_RS21790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV033_RS21795	COG2183	response to ionizing radiation
HV033_RS21800	COG1918	ferrous iron import across plasma membrane
HV033_RS21820	COG1040	competence protein
HV033_RS21830	COG2610	gluconate transmembrane transporter activity
HV033_RS21835	COG1640	4-alpha-glucanotransferase
HV033_RS21840	COG0058	SHG alpha-glucan phosphorylase activity
HV033_RS21845	COG2909	trisaccharide binding
HV033_RS21850	COG1349	DNA-binding transcription factor activity
HV033_RS21855	COG0705	Rhomboid family
HV033_RS21860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV033_RS21865	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV033_RS21870	COG0058	SHG alpha-glucan phosphorylase activity
HV033_RS21875	COG0297	glycogen (starch) synthase activity
HV033_RS21880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HV033_RS21885	COG1523	belongs to the glycosyl hydrolase 13 family
HV033_RS21890	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HV033_RS21895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV033_RS21900	COG2095	MarC family integral membrane protein
HV033_RS21905	COG2610	gluconate transmembrane transporter activity
HV033_RS21910	COG3265	gluconokinase activity
HV033_RS21915	COG1609	Transcriptional regulator
HV033_RS21920	COG1741	Belongs to the pirin family
HV033_RS21925	COG0673	inositol 2-dehydrogenase activity
HV033_RS21930	COG1247	-acetyltransferase
HV033_RS21935	COG0405	Gamma-glutamyltransferase
HV033_RS21945	COG0584	glycerophosphoryl diester phosphodiesterase
HV033_RS21975	COG0411	ABC transporter
HV033_RS21990	COG0683	leucine binding
HV033_RS22000	COG0683	leucine binding
HV033_RS22005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV033_RS22010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HV033_RS22015	COG2177	Part of the ABC transporter FtsEX involved in
HV033_RS22020	COG2884	Cell division ATP-binding protein ftsE
HV033_RS22025	COG0552	protein localization to endoplasmic reticulum
HV033_RS22030	COG0742	ribosomal rna small subunit methyltransferase
HV033_RS22035	COG3776	membrane
HV033_RS22045	COG3714	YhhN family
HV033_RS22050	COG2217	Heavy metal translocating P-type atpase
HV033_RS22065	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV033_RS22070	COG0425	Belongs to the sulfur carrier protein TusA family
HV033_RS22075	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV033_RS22085	COG0628	permease
HV033_RS22105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HV033_RS22125	COG1216	Glycosyl transferase, family 2
HV033_RS22150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV033_RS22160	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS22165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV033_RS22175	COG3479	Phenolic acid decarboxylase
HV033_RS22180	COG0583	DNA-binding transcription factor activity
HV033_RS22185	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS22205	COG1414	Transcriptional regulator
HV033_RS22210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HV033_RS22215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV033_RS22225	COG2205	protein histidine kinase activity
HV033_RS22230	COG0745	RESPONSE REGULATOR receiver
HV033_RS22235	COG1276	copper resistance
HV033_RS22240	COG2372	response to copper ion
HV033_RS22245	COG3667	copper resistance
HV033_RS22250	COG2132	Multicopper oxidase
HV033_RS22260	COG0739	heme binding
HV033_RS22290	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV033_RS22355	COG2081	HI0933 family
HV033_RS22360	COG0306	phosphate transporter
HV033_RS22370	COG0589	response to stress
HV033_RS22375	COG0742	ribosomal rna small subunit methyltransferase
HV033_RS22380	COG0339	signal peptide processing
HV033_RS22385	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV033_RS22390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV033_RS22405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV033_RS22415	COG2197	response regulator
HV033_RS22420	COG1028	Short-chain dehydrogenase reductase Sdr
HV033_RS22425	COG0583	DNA-binding transcription factor activity
HV033_RS22430	COG1295	ribonuclease BN
HV033_RS22435	COG0477	Major facilitator Superfamily
HV033_RS22440	COG2982	Protein involved in outer membrane biogenesis
HV033_RS22445	COG2200	EAL domain
HV033_RS22455	COG0612	Peptidase, M16
HV033_RS22460	COG1301	dicarboxylic acid transport
HV033_RS22465	COG2199	diguanylate cyclase activity
HV033_RS22465	COG2200	EAL domain
HV033_RS22470	COG3118	belongs to the thioredoxin family
HV033_RS22470	COG0457	Tetratricopeptide repeat
HV033_RS22475	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HV033_RS22480	COG1215	transferase activity, transferring glycosyl groups
HV033_RS22510	COG2194	sulfuric ester hydrolase activity
HV033_RS22520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV033_RS22550	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HV033_RS22560	COG1739	Uncharacterized protein family UPF0029
HV033_RS22565	COG0006	proline dipeptidase activity
HV033_RS22570	COG1024	Enoyl-CoA hydratase
HV033_RS22570	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV033_RS22575	COG0183	Belongs to the thiolase family
HV033_RS22580	COG0751	glycine-tRNA ligase activity
HV033_RS22585	COG0752	glycyl-tRNA synthetase alpha subunit
HV033_RS22595	COG3274	enterobacterial common antigen metabolic process
HV033_RS22600	COG1070	Carbohydrate kinase
HV033_RS22605	COG2115	Belongs to the xylose isomerase family
HV033_RS22610	COG4213	ABC transporter substrate-binding protein
HV033_RS22620	COG4214	carbohydrate transport
HV033_RS22625	COG2207	Transcriptional regulator
HV033_RS22625	COG1609	Transcriptional regulator
HV033_RS22630	COG2992	FlgJ-related protein
HV033_RS22635	COG0366	Alpha amylase catalytic
HV033_RS22640	COG3977	Valine--pyruvate aminotransferase
HV033_RS22645	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV033_RS22650	COG1414	Transcriptional regulator
HV033_RS22660	COG2731	YhcH YjgK YiaL family protein
HV033_RS22670	COG2271	Major facilitator Superfamily
HV033_RS22675	COG1070	Carbohydrate kinase
HV033_RS22680	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HV033_RS22685	COG3623	hexulose-6-phosphate isomerase
HV033_RS22690	COG0235	Class ii aldolase
HV033_RS22720	COG1012	belongs to the aldehyde dehydrogenase family
HV033_RS22725	COG1940	carbohydrate kinase activity
HV033_RS22730	COG3276	selenocysteine insertion sequence binding
HV033_RS22740	COG0625	glutathione transferase activity
HV033_RS22745	COG2213	PTS system mannitol-specific
HV033_RS22745	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV033_RS22755	COG3722	fumarate hydratase activity
HV033_RS22770	COG3188	usher protein
HV033_RS22775	COG3121	Chaperone
HV033_RS22780	COG3539	Fimbrial protein
HV033_RS22790	COG2186	Transcriptional regulator
HV033_RS22795	COG1304	FMN binding
HV033_RS22800	COG2271	Major facilitator Superfamily
HV033_RS22805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV033_RS22815	COG0583	DNA-binding transcription factor activity
HV033_RS22820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV033_RS22830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV033_RS22835	COG3978	acetolactate synthase activity
HV033_RS22855	COG3085	chromosome segregation
HV033_RS22905	COG4206	TonB-dependent receptor
HV033_RS22910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV033_RS22930	COG0583	DNA-binding transcription factor activity
HV033_RS22935	COG0165	Argininosuccinate lyase
HV033_RS22945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HV033_RS22950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV033_RS22955	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HV033_RS22960	COG2207	Transcriptional regulator
HV033_RS22970	COG0371	Dehydrogenase
HV033_RS22975	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HV033_RS22980	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HV033_RS22985	COG0460	homoserine dehydrogenase
HV033_RS22985	COG0527	aspartate kinase activity
HV033_RS22990	COG0626	cystathionine gamma-synthase activity
HV033_RS23000	COG0254	rRNA binding
HV033_RS23005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV033_RS23010	COG1609	Transcriptional regulator
HV033_RS23015	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV033_RS23030	COG1575	Belongs to the MenA family. Type 1 subfamily
HV033_RS23040	COG3074	FtsZ-dependent cytokinesis
HV033_RS23045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV033_RS23050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV033_RS23055	COG1494	fructose-1,6-bisphosphatase
HV033_RS23065	COG3152	Membrane
HV033_RS23075	COG0149	triose-phosphate isomerase activity
HV033_RS23085	COG2134	cdp-diacylglycerol pyrophosphatase
HV033_RS23095	COG0205	6-phosphofructokinase activity
HV033_RS23105	COG3678	ATP-independent chaperone mediated protein folding
HV033_RS23110	COG0745	RESPONSE REGULATOR receiver
HV033_RS23115	COG2205	protein histidine kinase activity
HV033_RS23120	COG2258	MOSC domain
HV033_RS23125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV033_RS23135	COG1917	Cupin 2, conserved barrel domain protein
HV033_RS23135	COG4977	sequence-specific DNA binding
HV033_RS23140	COG4977	sequence-specific DNA binding
HV033_RS23145	COG1070	Carbohydrate kinase
HV033_RS23150	COG4806	L-rhamnose isomerase
HV033_RS23155	COG0235	Class ii aldolase
HV033_RS23165	COG1129	ABC transporter
HV033_RS23170	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV033_RS23180	COG1454	alcohol dehydrogenase
HV033_RS23185	COG3254	rhamnose metabolic process
HV033_RS23190	COG3121	Chaperone
HV033_RS23200	COG3188	usher protein
HV033_RS23205	COG3121	Chaperone
HV033_RS23220	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV033_RS23245	COG0437	4 iron, 4 sulfur cluster binding
HV033_RS23250	COG2864	formate dehydrogenase
HV033_RS23255	COG3058	Necessary for formate dehydrogenase activity
HV033_RS23265	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV033_RS23275	COG0456	acetyltransferase
HV033_RS23290	COG1011	Hydrolase
HV033_RS23295	COG1349	DNA-binding transcription factor activity
HV033_RS23300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV033_RS23310	COG3684	Belongs to the aldolase LacD family
HV033_RS23320	COG1501	Belongs to the glycosyl hydrolase 31 family
HV033_RS23335	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV033_RS23350	COG3852	Histidine kinase
HV033_RS23365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV033_RS23370	COG3078	GTPase activator activity
HV033_RS23385	COG0204	Acyl-transferase
HV033_RS23395	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HV033_RS23400	COG3084	Protein conserved in bacteria
HV033_RS23405	COG0746	molybdenum cofactor guanylyltransferase activity
HV033_RS23410	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV033_RS23435	COG2186	Transcriptional regulator
HV033_RS23440	COG0477	Major facilitator Superfamily
HV033_RS23445	COG1609	Transcriptional regulator
HV033_RS23450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV033_RS23460	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV033_RS23465	COG1129	ABC transporter
HV033_RS23470	COG1869	D-ribose catabolic process
HV033_RS23475	COG3158	transport of potassium into the cell
HV033_RS23485	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HV033_RS23490	COG2502	aspartate--ammonia ligase
HV033_RS23495	COG1522	sequence-specific DNA binding
HV033_RS23500	COG0716	FMN binding
HV033_RS23505	COG0445	tRNA wobble uridine modification
HV033_RS23510	COG0357	Ribosomal RNA small subunit methyltransferase G
HV033_RS23515	COG3312	ion transport
HV033_RS23520	COG0356	it plays a direct role in the translocation of protons across the membrane
HV033_RS23530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HV033_RS23535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HV033_RS23540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HV033_RS23550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HV033_RS23555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV033_RS23560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV033_RS23570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV033_RS23575	COG0573	inorganic phosphate transmembrane transporter activity
HV033_RS23580	COG0581	inorganic phosphate transmembrane transporter activity
HV033_RS23585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HV033_RS23590	COG0704	Plays a role in the regulation of phosphate uptake
HV033_RS23595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV033_RS23600	COG2252	PERMEase
HV033_RS23605	COG0431	NADPH-dependent FMN reductase
HV033_RS23610	COG2091	lysine biosynthetic process via aminoadipic acid
HV033_RS23630	COG0706	membrane insertase activity
HV033_RS23690	COG2205	protein histidine kinase activity
HV033_RS23695	COG0745	RESPONSE REGULATOR receiver
HV033_RS23700	COG1276	copper resistance
HV033_RS23705	COG2372	response to copper ion
HV033_RS23710	COG3667	copper resistance
HV033_RS23715	COG2132	Multicopper oxidase
HV033_RS23725	COG0739	heme binding
HV033_RS23750	COG3436	PFAM IS66 Orf2 family protein
HV033_RS23755	COG4372	Transposase
HV033_RS23775	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV033_RS23985	COG1475	DNA binding
HV033_RS24015	COG2801	Transposase and inactivated derivatives
HV033_RS24020	COG3111	PFAM Bacterial OB fold (BOF) protein
HV033_RS24035	COG2814	Major facilitator Superfamily
HV033_RS24085	COG3077	Addiction module antitoxin, RelB DinJ family
HV033_RS24090	COG2026	Addiction module toxin, RelE StbE family
HV033_RS24195	COG2223	nitrite transmembrane transporter activity
HV033_RS24205	COG1609	Transcriptional regulator
HV033_RS24235	COG3436	PFAM IS66 Orf2 family protein
HV033_RS24240	COG1120	ATPase activity
HV033_RS24245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV033_RS24250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV033_RS24255	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HV033_RS24260	COG4772	TonB-dependent receptor
HV033_RS24265	COG3712	iron ion homeostasis
HV033_RS24270	COG1595	DNA-templated transcription, initiation
HV033_RS24310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV033_RS24315	COG0501	Belongs to the peptidase M48B family
HV033_RS24375	COG0542	response to heat
HV033_RS24380	COG0071	Belongs to the small heat shock protein (HSP20) family